id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300445-qzu4gz2d	Zhang, Xiao-lei	Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives	2020-09-23		.txt	text/plain	7247	376	37	Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. However, chloroquine phosphate and its derivative hydroxychloroquine, which have been used for decades in the treatment and prevention of malaria and chronic inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, were discovered to have a high inhibitory potency against SARS-CoV-2 infection in vitro [2] [3] [4] [5] and favorable clinical and virologic benefits in COVID-19 patients [6] [7] [8] [9] [10] , and they have emerged as important therapies for COVID-19 in several countries, including China, France, USA, and India, although the mechanisms of their anti-COVID-19 effects remain unclear.	./cache/cord-300445-qzu4gz2d.txt	./txt/cord-300445-qzu4gz2d.txt