id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278142-xnkqg4ef	Lin, Fang	Cobrotoxin could be an effective therapeutic for COVID-19	2020-08-25		.txt	text/plain	1970	112	42	Based on previous studies of cobra venom by the authors and other independent researchers, cobrotoxin, a short-chain αneurotoxin from Naja naja atra venom (NNAV), could be an alternative therapy for COVID-19. In addition, cobrotoxin was shown to attenuate LPSinduced pulmonary edema, decrease the number of hematological CD4 + T cells, inhibit immune cell accumulation in bronchoalveolar lavage fluid, and inhibit pro-inflammatory cytokine excretion in rat acute lung injury and acute respiratory distress syndrome [6] . At this time, it is believed that cobrotoxin has the potential to treat patients with COVID-19 or to inhibit SARS-COV-2 infection. 1. Anti-inflammatory activity: NNAV and α-neurotoxins have strong inhibitory effects on inflammation; thus, they could inhibit the cytokine storm caused by SARS-COV2 infection. NNAV also increases the concentration of serum IgG and IgM in mice with dexamethasone-induced immunosuppression, suggesting that NNAV or cobrotoxin could have the potential to restore the immune balance in patients with COVID-19.	./cache/cord-278142-xnkqg4ef.txt	./txt/cord-278142-xnkqg4ef.txt