id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013717-e0cai9j3	Fusi, Fabio	Ritanserin blocks Ca(V)1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies	2020-03-04		.txt	text/plain	7142	342	51	In contrast, ketanserin-induced inhibition of current amplitude was b Average traces (recorded from five cells) of I Ca1.2 , elicited with 250 ms clamp pulses to 10 mV from a V h of −80 mV, measured in the absence (control) or presence of cumulative concentrations of ritanserin. The major findings supporting this conclusion are as follows: (1) in single vascular myocytes, ritanserin inhibited I Ca1.2 in a concentration-dependent manner; (2) this inhibition was antagonized by the Ca V 1.2 stimulator Bay K 8644 and was likely due to the interaction of ritanserin with the channel protein; (3) ritanserin stabilized the Ca V 1.2 channel in its inactivated state; and (4) since ritanserin relaxed vascular smooth muscle contraction resulting from the opening of Ca V 1.2 channels, the I Ca1.2 blockade is supposed to have functional relevance and supports previous data obtained in vascular and nonvascular tissues [15] [16] [17] , where such mechanism of action was hypothesized to account for the relaxant effects of the drug.	./cache/cord-013717-e0cai9j3.txt	./txt/cord-013717-e0cai9j3.txt