id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013591-goaokk04	Ren, Si-yu	Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors	2020-03-18		.txt	text/plain	7133	330	30	The inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. Because the action of hydrolase on endocannabinoids increases endocannabinoid levels indirectly and thus causes fewer side effects than direct exogenous supplementation, two types of hydrolases, fatty acids amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), have been examined as potential new drug targets for CNS disorders. Based on the hydrolytic mechanism of FAAH and MAGL, the study of endocannabinoids and their receptor system, as well as their potential therapeutic applications in several nervous system disorders, cancers, and neuroinflammatory diseases, a large number of irreversible/reversible inhibitors have been used to explore the different selectivities of these two enzymes.	./cache/cord-013591-goaokk04.txt	./txt/cord-013591-goaokk04.txt