id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013567-qnp65w53	Cheng, Qiao-qiao	Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction	2020-03-12		.txt	text/plain	7161	388	42	Our results suggest that GAS may protect H9c2 cardiomycytes against oxidative injury via increasing the nuclear translocation of Nrf2, regulating mitochondrial dynamics, and maintaining the structure and functions of mitochondria. Quantitative analysis of mitochondrial network characteristics showed similar results: in Nrf2-siRNA-treated cells, GAS pretreatment did not ameliorate the decrease in mitochondrial footprint, mean branch length, or median branch length induced by H 2 O 2 (Fig. 7c) . Knockdown of Nrf2 expression attenuated the effects of GAS on H 2 O 2 -induced mitochondrial dysfunction As shown in Fig. 9a , in negative control cells, H 2 O 2 treatment induced a considerable decrease in mitochondrial respiration potency, while GAS pretreatment partly ameliorates the H 2 O 2induced mitochondrial dysfunction. Importantly, in Nrf2-siRNA-treated cells, H 2 O 2 treatment also induced a considerable decrease in mitochondrial respiration potency, but GAS pretreatment did not ameliorate the H 2 O 2induced mitochondrial dysfunction (Fig. 9a) .	./cache/cord-013567-qnp65w53.txt	./txt/cord-013567-qnp65w53.txt