id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012840-tgcrg5db	Liu, Hao-chen	PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats	2020-01-13		.txt	text/plain	5660	363	54	Then this model was used to perform simulations, thus to propose an anti-hypertension indication, according to which the anti-hypertension treatment might yield relative low-level AUC and fluctuation of blood pressure. The simulation results suggest that the anti-hypertension agent may yield low-level AUC and fluctuation of blood pressure when relative ET-1 level ranges from −15% to 5% and relative NO level is more than 10% compared to control group. The aim of this study was to develop a mechanismbased pharmacokinetics-pharmacodynamic (PK/PD) model for proposing an optimized antihypertensive management method that can lower both blood pressure and its fluctuation in rats. Third, simulations based on the PK-PD model and progression analysis were performed according to the proposed hypothesis that the effect of antihypertensive treatment on blood pressure and its fluctuation are affected by variations in NO-ET homeostasis. Our study provides a mechanism-based model to optimize an antihypertensive treatment for hypertension induced by sunitinib that not only inhibits hypertension but also reduces blood pressure fluctuations in rats.	./cache/cord-012840-tgcrg5db.txt	./txt/cord-012840-tgcrg5db.txt