id author title date pages extension mime words sentences flesch summary cache txt cord-012822-8t6qg5fp Papoutsis, Konstantinos Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans 2020-02-05 .txt text/plain 5489 287 39 title: Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans The expression levels of metalloproteinases (MMPs) and endothelial nitric oxide synthetase (eNOS) were also detected for correlations with different phenotypes of atherosclerosis and AA. In the present study, we aimed to verify and expand the findings of our preliminary study for serum RL2 [9] by investigating the levels of tissue-specific RL2 in aneurysmal (AA) and atherosclerotic (ATH) arteries and establishing a correlation of tissue-specific RL2 levels with the presence/size of AA and the clinical severity of atherosclerosis. Moreover, we carried out tissue-specific measurements of MMP2, MMP9 and endothelial nitric oxide synthetase (eNOS) in the aforementioned groups of arterial specimens to investigate further correlations with different phenotypes of atherosclerosis and AA. AA aneurysm group, ATH atherosclerosis group, RL2 relaxin-2, MMP matrix metalloproteinase, eNOS endothelial nitric oxide synthetase Relaxin-2 in aneurysmatic and atherosclerotic disease K Papoutsis et al. ./cache/cord-012822-8t6qg5fp.txt ./txt/cord-012822-8t6qg5fp.txt