id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012770-wvf8swyj	Sun, Shu-zhen	β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK(1/2)-NF-κB signal pathway in murine hearts	2019-09-12		.txt	text/plain	5356	313	51	The above results suggest that AVP induces IL-6 induction in murine hearts via the V(1A) receptor-mediated β-arrestin2/ERK(1/2)/NF-κB pathway, thus reveal a novel mechanism of myocardial inflammation in heart failure involving the V(1A)/β-arrestin 2/ERK(1/2)/NF-κB signaling pathway. β-Arrestin 2 is required for AVP-induced NF-κB activation Our previous study demonstrated that AVP induces IL-6 production via NF-κB signaling in neonatal rat cardiac fibroblasts [33] and cultured ARCFs (Fig. 4) . The following results were found in the present study: (1) AVP increased the mRNA and protein levels of IL-6 in murine hearts; (2) the silencing or deletion of β-arrestin 2 reduced AVP-induced IL-6 production, NF-κB activation and ERK 1/2 phosphorylation; (3) the pharmacological inhibition of ERK 1/2 signaling diminished AVP-induced NF-κB activation and IL-6 production; and (4) the blockade of the V 1A receptor by the selective antagonist SR49059 abolished AVP-evoked NF-κB phosphorylation and IL-6 induction in intact hearts and ARCFs. AVP is an antidiuretic hormone that is secreted by the hypothalamus-pituitary-adrenal axis.	./cache/cord-012770-wvf8swyj.txt	./txt/cord-012770-wvf8swyj.txt