id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012769-clbqckj2	Yan, You-you	A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells	2020-02-11		.txt	text/plain	3747	233	44	title: A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells Valepotriate is the key bioactive component extracted from Valeriana and is reported to exert anti-proliferation cytotoxic effects by regulating the redox balance or suppressing the mitogen-activated protein kinase pathway in cancer cells [13, 14] . Amcp induced apoptosis in BxPC-3 and SW1990 cells A similarity search was employed to find derivatives of valepotriate that were potentially active against cancer cells and the results identified 16 hit compounds that were purchased for bioactivity tests. Combinatorial treatment with Amcp and gemcitabine synergistically induced apoptosis in BxPC-3 cells (Fig. 6b, d) and this effect could be partially overcome by the addition of the pancaspase inhibitor Z-VAD-FMK (Fig. 6c) . Amcp showed potent anticancer activity against pancreatic cancer cells through the inhibition of the Mcl-1 and PI3K/AKT pathways, thereby stimulating caspase-dependent apoptosis.	./cache/cord-012769-clbqckj2.txt	./txt/cord-012769-clbqckj2.txt