id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012760-p6fdc191	Liu, Can-zhao	Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation	2019-09-04		.txt	text/plain	4320	245	41	In cultured basilar artery smooth muscle cells (BASMCs) isolated from 2k2c renohypertesive rats, treatment with angiotensin II (0.125−1 μM) dose-dependently increased endophilin A2 levels and decreased TMEM16A expression. Our recent study found that CaCC activity in the cardiovascular system, as well as TMEM16A expression level, was decreased in basilar artery smooth muscle cells (BASMCs) isolated from twokidney two-clip (2k2c) renohypertensive rats, possibly caused by a high concentration of angiotensin II during hypertension [10] . Endophilin A2 is upregulated during hypertension We previously identified TMEM16A as the molecular identity of the CaCC in smooth muscle cells and found that CaCC activity was associated with a high concentration of angiotensin II in the basilar artery of the 2k2c renohypertensive rat model. Considering the significant upregulation of endophilin A2 in the basilar arteries isolated from the hypertension model, we hypothesized that overexpression of endophilin A2 could reduce TMEM16A protein expression by modulating TMEM16A ubiquitination, which would further lead to downregulation of CaCC activation.	./cache/cord-012760-p6fdc191.txt	./txt/cord-012760-p6fdc191.txt