id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012758-18c1rxg8	Wu, Xiao-li	Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury	2020-02-27		.txt	text/plain	5937	381	56	We further revealed that ramelteon significantly inhibited autophagy in the peri-infarct cortex in both the mouse ischemia models via regulating AMPK/mTOR signaling pathway. To explore the neuroprotective effect of ramelteon against acute ischemic brain injury, mice were subjected to middle cerebral artery occlusion (MCAO) (Fig. 1a) . We next determined the Fig. 1 Ramelteon protected against middle cerebral artery occlusion (MCAO)-induced acute ischemic brain injury. Overall, these data supported the involvement of the AMPK/mTOR signaling pathway and autophagy in ramelteon-conferred neuroprotection in either acute or chronic ischemic brain injury. Ramelteon may activate the AMPK/mTOR signaling pathway and inhibit ischemia-induced autophagy in a melatonin receptor-related manner (Fig. 6) . Considering the safety of ramelteon in clinical application, our data indicated Fig. 4 Ramelteon activated the AMPK/mTOR signaling pathway and inhibited autophagy in acute ischemic brain injury. It took Fig. 5 Ramelteon activated the AMPK/mTOR signaling pathway and suppressed autophagy in chronic ischemic brain injury.	./cache/cord-012758-18c1rxg8.txt	./txt/cord-012758-18c1rxg8.txt