id author title date pages extension mime words sentences flesch summary cache txt cord-012753-cu6qcen9 Qi, Fei-long Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells 2020-05-28 .txt text/plain 3779 215 31 title: Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells Based on the research of our group, we here introduce the new strategies being employed using nanoscale intelligent drug delivery systems to enhance the effects of cancer immunotherapy. In more recent years, cancer immunotherapy, which effectively kills cancer cells by enhancing immune system function in patients, has emerged as a new therapeutic approach [5, 6] . Many nanodrug delivery systems have achieved encouraging therapeutic efficacy in tumor inhibition through the codelivery of immune checkpoint inhibitors with other drugs or compounds expected to regulate the tumor microenvironment [33, 34] . It is generally accepted that tumor vaccines enable targeted delivery of tumor-associated antigens (TAAs) or adjuvants to DCs and induce long-lasting antitumor immune responses [75] [76] [77] [78] . Engineering nanoparticles for targeted remodeling of the tumor microenvironment to improve cancer immunotherapy ./cache/cord-012753-cu6qcen9.txt ./txt/cord-012753-cu6qcen9.txt