id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012726-1i1mj3jw	Chen, Xue-han	Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis	2019-06-13		.txt	text/plain	4977	264	52	In the second screen, the MM cell line LP1, which expresses a high level of c-Maf [5, 8] , was treated with all of the above drugs for 24 h, followed by IB assays to evaluate PARP cleavage, a hallmark of apoptosis, and c-Maf degradation. c-g LP1 and RPMI-8226 cells were treated with MBZ at the indicated concentrations for 24 h, followed by quantitative real-time PCR to measure the expression of genes, including USP5 (c), c-Maf (d), CCND2 (e), ITGB7 (f), and ARK5 (g). Therefore, mebendazole, especially at low concentrations, preferentially induces MM cell apoptosis in a manner dependent on the expression of c-Maf. Mebendazole exerts synergistic antimyeloma effects with a USP5 inhibitor Previous studies identified WP1130 as a small molecule compound that inhibits the deubiquitinase activity of USP5 [15] . Mebendazole delays the growth of human multiple myeloma xenografts in a nude mouse model The above studies provided strong evidence that mebendazole inhibits the USP5/c-Maf axis and induces MM cell apoptosis.	./cache/cord-012726-1i1mj3jw.txt	./txt/cord-012726-1i1mj3jw.txt