id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012720-eoovm5gh	Liu, Qi	Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway	2020-01-14		.txt	text/plain	6066	363	44	title: Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway In conclusion, these results demonstrate that oroxindin could be absorbed by the colon and attenuate inflammatory responses via inhibiting NLRP3 inflammasome formation and activation, which is related to the inhibitory effect on TXNIP-dependent NF-κB-signaling pathway. In the present study, we investigated the protective effects of oroxindin and the underlying mechanisms, and proved that oroxindin attenuates UC by inhibiting NLRP3 inflammasome activation via suppressing the TXNIP-dependent NF-κB-signaling pathway in colonic macrophages. According to the results, the expression of NLRP3 and caspase-1 was increased in macrophages in the DSS-treated mice, while oroxindin exerted specific protective effects in the inflamed tissue. Oroxindin could also suppress NLRP3 inflammasome activation by restoring TXNIP expression and inhibiting the TXNIP-dependent NF-κB-signaling pathway induced by LPS in macrophages.	./cache/cord-012720-eoovm5gh.txt	./txt/cord-012720-eoovm5gh.txt