id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012716-t19zmvm6	Guo, Chen-hong	Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin	2020-02-28		.txt	text/plain	5091	307	49	In this study, we employed DAT promoter-mediated Cre transgenic mice to establish tamoxifen-inducible Dicer conditional knockout (cKO) mice in an effort to mimic the progressive loss of DA neurons and the development of PD-like behavioral phenotypes. The results indicated that the chronic administration of either DHM or PRE-084 attenuated the Dicer cKO-induced loss of DA neurons and motor impairments, although the two drugs acted through different mechanisms. These results indicated that Dicer cKO in DA neurons in response to tamoxifen administration in adult mice induced the progressive development of PD-like phenotypes. Dicer cKO mice, which steadily developed PD-like behaviors in response to tamoxifen induction, were administered L-DOPA, and the results indicated that L-DOPA treatment significantly relieved motor impairments, as evidenced by performance on the pole test and rotarod test (Fig. 4) , indicating that the Dicer cKO mouse line can be used as an alternative animal model for evaluating the efficacy of PD drugs.	./cache/cord-012716-t19zmvm6.txt	./txt/cord-012716-t19zmvm6.txt