id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012682-7goljir4	Yuan, Meng	N-myristoylation: from cell biology to translational medicine	2020-03-18		.txt	text/plain	7187	347	38	N-myristoylation refers to the attachment of 14-carbon fatty acid myristates to the N-terminal glycine of proteins by N-myristoyltransferases (NMT) and affects their physiology such as plasma targeting, subcellular tracking and localization, thereby influencing the function of proteins. For example, it was reported that both N-myristoylation and palmitoylation appear to have opposing roles and different membrane lipid microdomain preferences for the G protein-membrane interactions I (Gαi1) monomer, which are likely due to the conformational differences in the presence of different fatty acids [31] . Potential targets of cancer treatments Given that altered NMT expression is observed in many types of cancer tissues and because many N-myristoylated proteins are involved in signaling processes that regulate cell proliferation, growth and death, it has been proposed that N-myristoylation or NMTs can be considered as therapeutic targets for cancer.	./cache/cord-012682-7goljir4.txt	./txt/cord-012682-7goljir4.txt