id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001268-sc0ersky	Zhang, Wei-ying	Gene expression profiles of human liver cells mediated by hepatitis B virus X protein	2009-04-03		.txt	text/plain	4503	246	48	AIM: To demonstrate the gene expression profiles mediated by hepatitis B virus X protein (HBx), we characterized the molecular features of pathogenesis associated with HBx in a human liver cell model. When compared with the gene expression profiles of H7402-X cells [10] , our findings provide new insight into the molecular mechanism of carcinogenesis mediated by HBx in human liver cells. To distinguish the differential expression of genes in normal human liver L-O2 cells and hepatoma cells mediated by HBx, we examined the differential expression profiles in L-O2-X cells by cDNA microarray analysis ( Figure 1 ). HBx was responsible for the upregulation of PCNA and Bcl-2 To further validate the candidate genes in the cDNA microarray and to preliminarily investigate the molecular alterations of proliferating cell nuclear antigen (PCNA) and Bcl-2 in the L-O2-X cell line, we examined the regulation of PCNA and Bcl-2 at the protein level by Western blot analysis.	./cache/cord-001268-sc0ersky.txt	./txt/cord-001268-sc0ersky.txt