id sid tid token lemma pos cord-029547-9ei1ram3 1 1 key key JJ cord-029547-9ei1ram3 1 2 : : : cord-029547-9ei1ram3 1 3 cord-029547 cord-029547 NNP cord-029547-9ei1ram3 1 4 - - HYPH cord-029547-9ei1ram3 1 5 9ei1ram3 9ei1ram3 CD cord-029547-9ei1ram3 1 6 authors author NNS cord-029547-9ei1ram3 1 7 : : : cord-029547-9ei1ram3 1 8 Li Li NNP cord-029547-9ei1ram3 1 9 , , , cord-029547-9ei1ram3 1 10 Jingwei Jingwei NNP cord-029547-9ei1ram3 1 11 ; ; : cord-029547-9ei1ram3 1 12 Shao Shao NNP cord-029547-9ei1ram3 1 13 , , , cord-029547-9ei1ram3 1 14 Jun Jun NNP cord-029547-9ei1ram3 1 15 ; ; : cord-029547-9ei1ram3 1 16 Wang Wang NNP cord-029547-9ei1ram3 1 17 , , , cord-029547-9ei1ram3 1 18 Chengdi Chengdi NNP cord-029547-9ei1ram3 1 19 ; ; : cord-029547-9ei1ram3 1 20 Li Li NNP cord-029547-9ei1ram3 1 21 , , , cord-029547-9ei1ram3 1 22 Weimin Weimin NNP cord-029547-9ei1ram3 1 23 title title NN cord-029547-9ei1ram3 1 24 : : : cord-029547-9ei1ram3 1 25 The the DT cord-029547-9ei1ram3 1 26 epidemiology epidemiology NN cord-029547-9ei1ram3 1 27 and and CC cord-029547-9ei1ram3 1 28 therapeutic therapeutic JJ cord-029547-9ei1ram3 1 29 options option NNS cord-029547-9ei1ram3 1 30 for for IN cord-029547-9ei1ram3 1 31 the the DT cord-029547-9ei1ram3 1 32 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 1 33 date date NN cord-029547-9ei1ram3 1 34 : : : cord-029547-9ei1ram3 1 35 2020 2020 CD cord-029547-9ei1ram3 1 36 - - HYPH cord-029547-9ei1ram3 1 37 05 05 CD cord-029547-9ei1ram3 1 38 - - HYPH cord-029547-9ei1ram3 1 39 28 28 CD cord-029547-9ei1ram3 1 40 journal journal NN cord-029547-9ei1ram3 1 41 : : : cord-029547-9ei1ram3 2 1 Precis Precis NNP cord-029547-9ei1ram3 2 2 Clin Clin NNP cord-029547-9ei1ram3 2 3 Med Med NNP cord-029547-9ei1ram3 2 4 DOI doi NN cord-029547-9ei1ram3 2 5 : : : cord-029547-9ei1ram3 2 6 10.1093 10.1093 CD cord-029547-9ei1ram3 2 7 / / SYM cord-029547-9ei1ram3 2 8 pcmedi pcmedi NNP cord-029547-9ei1ram3 2 9 / / SYM cord-029547-9ei1ram3 2 10 pbaa017 pbaa017 NNP cord-029547-9ei1ram3 2 11 sha sha NNP cord-029547-9ei1ram3 2 12 : : : cord-029547-9ei1ram3 2 13 ebc7ff0033a4064852d60670c095d6196d84b32e ebc7ff0033a4064852d60670c095d6196d84b32e NNP cord-029547-9ei1ram3 2 14 doc_id doc_id CD cord-029547-9ei1ram3 2 15 : : : cord-029547-9ei1ram3 2 16 29547 29547 CD cord-029547-9ei1ram3 2 17 cord_uid cord_uid NNS cord-029547-9ei1ram3 2 18 : : : cord-029547-9ei1ram3 3 1 9ei1ram3 9ei1ram3 CD cord-029547-9ei1ram3 4 1 An an DT cord-029547-9ei1ram3 4 2 outbreak outbreak NN cord-029547-9ei1ram3 4 3 of of IN cord-029547-9ei1ram3 4 4 coronavirus coronavirus NN cord-029547-9ei1ram3 4 5 disease disease NN cord-029547-9ei1ram3 4 6 2019 2019 CD cord-029547-9ei1ram3 4 7 ( ( -LRB- cord-029547-9ei1ram3 4 8 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 4 9 ) ) -RRB- cord-029547-9ei1ram3 4 10 , , , cord-029547-9ei1ram3 4 11 a a DT cord-029547-9ei1ram3 4 12 disease disease NN cord-029547-9ei1ram3 4 13 caused cause VBN cord-029547-9ei1ram3 4 14 by by IN cord-029547-9ei1ram3 4 15 a a DT cord-029547-9ei1ram3 4 16 novel novel JJ cord-029547-9ei1ram3 4 17 pneumonia pneumonia NN cord-029547-9ei1ram3 4 18 virus virus NN cord-029547-9ei1ram3 4 19 , , , cord-029547-9ei1ram3 4 20 has have VBZ cord-029547-9ei1ram3 4 21 affected affect VBN cord-029547-9ei1ram3 4 22 over over IN cord-029547-9ei1ram3 4 23 200 200 CD cord-029547-9ei1ram3 4 24 countries country NNS cord-029547-9ei1ram3 4 25 and and CC cord-029547-9ei1ram3 4 26 regions region NNS cord-029547-9ei1ram3 4 27 worldwide worldwide RB cord-029547-9ei1ram3 4 28 . . . cord-029547-9ei1ram3 5 1 With with IN cord-029547-9ei1ram3 5 2 the the DT cord-029547-9ei1ram3 5 3 increasing increase VBG cord-029547-9ei1ram3 5 4 number number NN cord-029547-9ei1ram3 5 5 of of IN cord-029547-9ei1ram3 5 6 patients patient NNS cord-029547-9ei1ram3 5 7 and and CC cord-029547-9ei1ram3 5 8 deaths death NNS cord-029547-9ei1ram3 5 9 , , , cord-029547-9ei1ram3 5 10 WHO who WP cord-029547-9ei1ram3 5 11 have have VBP cord-029547-9ei1ram3 5 12 declared declare VBN cord-029547-9ei1ram3 5 13 it -PRON- PRP cord-029547-9ei1ram3 5 14 as as IN cord-029547-9ei1ram3 5 15 a a DT cord-029547-9ei1ram3 5 16 global global JJ cord-029547-9ei1ram3 5 17 pandemic pandemic NN cord-029547-9ei1ram3 5 18 currently currently RB cord-029547-9ei1ram3 5 19 , , , cord-029547-9ei1ram3 5 20 indicating indicate VBG cord-029547-9ei1ram3 5 21 a a DT cord-029547-9ei1ram3 5 22 third third JJ cord-029547-9ei1ram3 5 23 large large JJ cord-029547-9ei1ram3 5 24 - - HYPH cord-029547-9ei1ram3 5 25 scale scale NN cord-029547-9ei1ram3 5 26 epidemic epidemic NN cord-029547-9ei1ram3 5 27 coronavirus coronavirus NN cord-029547-9ei1ram3 5 28 has have VBZ cord-029547-9ei1ram3 5 29 appeared appear VBN cord-029547-9ei1ram3 5 30 since since IN cord-029547-9ei1ram3 5 31 the the DT cord-029547-9ei1ram3 5 32 emergence emergence NN cord-029547-9ei1ram3 5 33 of of IN cord-029547-9ei1ram3 5 34 severe severe JJ cord-029547-9ei1ram3 5 35 acute acute JJ cord-029547-9ei1ram3 5 36 respiratory respiratory JJ cord-029547-9ei1ram3 5 37 syndrome syndrome NN cord-029547-9ei1ram3 5 38 coronavirus coronavirus NN cord-029547-9ei1ram3 5 39 ( ( -LRB- cord-029547-9ei1ram3 5 40 SARS SARS NNP cord-029547-9ei1ram3 5 41 ) ) -RRB- cord-029547-9ei1ram3 5 42 and and CC cord-029547-9ei1ram3 5 43 Middle Middle NNP cord-029547-9ei1ram3 5 44 - - HYPH cord-029547-9ei1ram3 5 45 East East NNP cord-029547-9ei1ram3 5 46 respiratory respiratory JJ cord-029547-9ei1ram3 5 47 syndrome syndrome NN cord-029547-9ei1ram3 5 48 ( ( -LRB- cord-029547-9ei1ram3 5 49 MERS MERS NNP cord-029547-9ei1ram3 5 50 ) ) -RRB- cord-029547-9ei1ram3 5 51 in in IN cord-029547-9ei1ram3 5 52 the the DT cord-029547-9ei1ram3 5 53 twenty twenty CD cord-029547-9ei1ram3 5 54 - - HYPH cord-029547-9ei1ram3 5 55 first first JJ cord-029547-9ei1ram3 5 56 century century NN cord-029547-9ei1ram3 5 57 . . . cord-029547-9ei1ram3 6 1 Considering consider VBG cord-029547-9ei1ram3 6 2 the the DT cord-029547-9ei1ram3 6 3 great great JJ cord-029547-9ei1ram3 6 4 harm harm NN cord-029547-9ei1ram3 6 5 it -PRON- PRP cord-029547-9ei1ram3 6 6 has have VBZ cord-029547-9ei1ram3 6 7 caused cause VBN cord-029547-9ei1ram3 6 8 , , , cord-029547-9ei1ram3 6 9 researchers researcher NNS cord-029547-9ei1ram3 6 10 throughout throughout IN cord-029547-9ei1ram3 6 11 the the DT cord-029547-9ei1ram3 6 12 world world NN cord-029547-9ei1ram3 6 13 have have VBP cord-029547-9ei1ram3 6 14 been be VBN cord-029547-9ei1ram3 6 15 chasing chase VBG cord-029547-9ei1ram3 6 16 to to TO cord-029547-9ei1ram3 6 17 exploit exploit VB cord-029547-9ei1ram3 6 18 the the DT cord-029547-9ei1ram3 6 19 pathophysiology pathophysiology NN cord-029547-9ei1ram3 6 20 , , , cord-029547-9ei1ram3 6 21 characteristics characteristic NNS cord-029547-9ei1ram3 6 22 , , , cord-029547-9ei1ram3 6 23 and and CC cord-029547-9ei1ram3 6 24 potential potential JJ cord-029547-9ei1ram3 6 25 remedies remedy NNS cord-029547-9ei1ram3 6 26 for for IN cord-029547-9ei1ram3 6 27 COVID-19 covid-19 CD cord-029547-9ei1ram3 6 28 to to TO cord-029547-9ei1ram3 6 29 better well JJR cord-029547-9ei1ram3 6 30 battle battle VB cord-029547-9ei1ram3 6 31 the the DT cord-029547-9ei1ram3 6 32 outbreak outbreak NN cord-029547-9ei1ram3 6 33 . . . cord-029547-9ei1ram3 7 1 Therefore therefore RB cord-029547-9ei1ram3 7 2 , , , cord-029547-9ei1ram3 7 3 the the DT cord-029547-9ei1ram3 7 4 current current JJ cord-029547-9ei1ram3 7 5 study study NN cord-029547-9ei1ram3 7 6 revisits revisit VBZ cord-029547-9ei1ram3 7 7 advances advance NNS cord-029547-9ei1ram3 7 8 of of IN cord-029547-9ei1ram3 7 9 the the DT cord-029547-9ei1ram3 7 10 virology virology NN cord-029547-9ei1ram3 7 11 , , , cord-029547-9ei1ram3 7 12 epidemiology epidemiology NN cord-029547-9ei1ram3 7 13 , , , cord-029547-9ei1ram3 7 14 clinical clinical JJ cord-029547-9ei1ram3 7 15 features feature NNS cord-029547-9ei1ram3 7 16 , , , cord-029547-9ei1ram3 7 17 therapeutic therapeutic JJ cord-029547-9ei1ram3 7 18 options option NNS cord-029547-9ei1ram3 7 19 , , , cord-029547-9ei1ram3 7 20 and and CC cord-029547-9ei1ram3 7 21 prevention prevention NN cord-029547-9ei1ram3 7 22 of of IN cord-029547-9ei1ram3 7 23 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 7 24 . . . cord-029547-9ei1ram3 8 1 The the DT cord-029547-9ei1ram3 8 2 features feature NNS cord-029547-9ei1ram3 8 3 of of IN cord-029547-9ei1ram3 8 4 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 8 5 carriers carrier NNS cord-029547-9ei1ram3 8 6 are be VBP cord-029547-9ei1ram3 8 7 also also RB cord-029547-9ei1ram3 8 8 been be VBN cord-029547-9ei1ram3 8 9 explored explore VBN cord-029547-9ei1ram3 8 10 . . . cord-029547-9ei1ram3 9 1 At at IN cord-029547-9ei1ram3 9 2 the the DT cord-029547-9ei1ram3 9 3 end end NN cord-029547-9ei1ram3 9 4 of of IN cord-029547-9ei1ram3 9 5 2019 2019 CD cord-029547-9ei1ram3 9 6 , , , cord-029547-9ei1ram3 9 7 a a DT cord-029547-9ei1ram3 9 8 sudden sudden JJ cord-029547-9ei1ram3 9 9 outbreak outbreak NN cord-029547-9ei1ram3 9 10 of of IN cord-029547-9ei1ram3 9 11 pneumonia pneumonia NN cord-029547-9ei1ram3 9 12 occurred occur VBD cord-029547-9ei1ram3 9 13 in in IN cord-029547-9ei1ram3 9 14 Wuhan Wuhan NNP cord-029547-9ei1ram3 9 15 , , , cord-029547-9ei1ram3 9 16 China China NNP cord-029547-9ei1ram3 9 17 , , , cord-029547-9ei1ram3 9 18 which which WDT cord-029547-9ei1ram3 9 19 was be VBD cord-029547-9ei1ram3 9 20 later later RB cord-029547-9ei1ram3 9 21 confirmed confirm VBN cord-029547-9ei1ram3 9 22 to to TO cord-029547-9ei1ram3 9 23 be be VB cord-029547-9ei1ram3 9 24 caused cause VBN cord-029547-9ei1ram3 9 25 by by IN cord-029547-9ei1ram3 9 26 a a DT cord-029547-9ei1ram3 9 27 coronavirus coronavirus NN cord-029547-9ei1ram3 9 28 , , , cord-029547-9ei1ram3 9 29 severe severe JJ cord-029547-9ei1ram3 9 30 acute acute JJ cord-029547-9ei1ram3 9 31 respiratory respiratory JJ cord-029547-9ei1ram3 9 32 syndrome syndrome NN cord-029547-9ei1ram3 9 33 coronavirus coronavirus NN cord-029547-9ei1ram3 9 34 2 2 CD cord-029547-9ei1ram3 9 35 ( ( -LRB- cord-029547-9ei1ram3 9 36 SARS SARS NNP cord-029547-9ei1ram3 9 37 - - HYPH cord-029547-9ei1ram3 9 38 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 9 39 ) ) -RRB- cord-029547-9ei1ram3 9 40 . . . cord-029547-9ei1ram3 10 1 1,2 1,2 LS cord-029547-9ei1ram3 11 1 Soon soon RB cord-029547-9ei1ram3 11 2 after after RB cord-029547-9ei1ram3 11 3 , , , cord-029547-9ei1ram3 11 4 the the DT cord-029547-9ei1ram3 11 5 virus virus NN cord-029547-9ei1ram3 11 6 spread spread VBD cord-029547-9ei1ram3 11 7 rapidly rapidly RB cord-029547-9ei1ram3 11 8 around around IN cord-029547-9ei1ram3 11 9 the the DT cord-029547-9ei1ram3 11 10 world world NN cord-029547-9ei1ram3 11 11 and and CC cord-029547-9ei1ram3 11 12 affected affect VBN cord-029547-9ei1ram3 11 13 human human JJ cord-029547-9ei1ram3 11 14 health health NN cord-029547-9ei1ram3 11 15 as as RB cord-029547-9ei1ram3 11 16 well well RB cord-029547-9ei1ram3 11 17 as as IN cord-029547-9ei1ram3 11 18 causing cause VBG cord-029547-9ei1ram3 11 19 huge huge JJ cord-029547-9ei1ram3 11 20 economic economic JJ cord-029547-9ei1ram3 11 21 losses loss NNS cord-029547-9ei1ram3 11 22 to to IN cord-029547-9ei1ram3 11 23 society society NN cord-029547-9ei1ram3 11 24 . . . cord-029547-9ei1ram3 12 1 [ [ -LRB- cord-029547-9ei1ram3 12 2 3 3 CD cord-029547-9ei1ram3 12 3 ] ] -RRB- cord-029547-9ei1ram3 12 4 [ [ -LRB- cord-029547-9ei1ram3 12 5 4 4 CD cord-029547-9ei1ram3 12 6 ] ] -RRB- cord-029547-9ei1ram3 12 7 [ [ -LRB- cord-029547-9ei1ram3 12 8 5 5 CD cord-029547-9ei1ram3 12 9 ] ] -RRB- cord-029547-9ei1ram3 13 1 On on IN cord-029547-9ei1ram3 13 2 12 12 CD cord-029547-9ei1ram3 13 3 February February NNP cord-029547-9ei1ram3 13 4 2020 2020 CD cord-029547-9ei1ram3 13 5 , , , cord-029547-9ei1ram3 13 6 this this DT cord-029547-9ei1ram3 13 7 novel novel JJ cord-029547-9ei1ram3 13 8 disease disease NN cord-029547-9ei1ram3 13 9 was be VBD cord-029547-9ei1ram3 13 10 named name VBN cord-029547-9ei1ram3 13 11 coronavirus coronavirus NN cord-029547-9ei1ram3 13 12 disease disease NN cord-029547-9ei1ram3 13 13 2019 2019 CD cord-029547-9ei1ram3 13 14 ( ( -LRB- cord-029547-9ei1ram3 13 15 COVID-19 covid-19 VB cord-029547-9ei1ram3 13 16 ) ) -RRB- cord-029547-9ei1ram3 13 17 by by IN cord-029547-9ei1ram3 13 18 WHO WHO NNP cord-029547-9ei1ram3 13 19 . . . cord-029547-9ei1ram3 14 1 6 6 CD cord-029547-9ei1ram3 15 1 Since since IN cord-029547-9ei1ram3 15 2 then then RB cord-029547-9ei1ram3 15 3 , , , cord-029547-9ei1ram3 15 4 medical medical JJ cord-029547-9ei1ram3 15 5 experts expert NNS cord-029547-9ei1ram3 15 6 around around IN cord-029547-9ei1ram3 15 7 the the DT cord-029547-9ei1ram3 15 8 world world NN cord-029547-9ei1ram3 15 9 have have VBP cord-029547-9ei1ram3 15 10 been be VBN cord-029547-9ei1ram3 15 11 trying try VBG cord-029547-9ei1ram3 15 12 to to TO cord-029547-9ei1ram3 15 13 find find VB cord-029547-9ei1ram3 15 14 the the DT cord-029547-9ei1ram3 15 15 control control NN cord-029547-9ei1ram3 15 16 measures measure NNS cord-029547-9ei1ram3 15 17 and and CC cord-029547-9ei1ram3 15 18 treatment treatment NN cord-029547-9ei1ram3 15 19 for for IN cord-029547-9ei1ram3 15 20 it -PRON- PRP cord-029547-9ei1ram3 15 21 . . . cord-029547-9ei1ram3 16 1 Because because IN cord-029547-9ei1ram3 16 2 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 16 3 is be VBZ cord-029547-9ei1ram3 16 4 highly highly RB cord-029547-9ei1ram3 16 5 contagious contagious JJ cord-029547-9ei1ram3 16 6 , , , cord-029547-9ei1ram3 16 7 the the DT cord-029547-9ei1ram3 16 8 number number NN cord-029547-9ei1ram3 16 9 of of IN cord-029547-9ei1ram3 16 10 patients patient NNS cord-029547-9ei1ram3 16 11 has have VBZ cord-029547-9ei1ram3 16 12 increased increase VBN cord-029547-9ei1ram3 16 13 rapidly rapidly RB cord-029547-9ei1ram3 16 14 . . . cord-029547-9ei1ram3 17 1 Thus thus RB cord-029547-9ei1ram3 17 2 , , , cord-029547-9ei1ram3 17 3 realizing realize VBG cord-029547-9ei1ram3 17 4 its -PRON- PRP$ cord-029547-9ei1ram3 17 5 basic basic JJ cord-029547-9ei1ram3 17 6 characteristics characteristic NNS cord-029547-9ei1ram3 17 7 and and CC cord-029547-9ei1ram3 17 8 finding find VBG cord-029547-9ei1ram3 17 9 appropriate appropriate JJ cord-029547-9ei1ram3 17 10 methods method NNS cord-029547-9ei1ram3 17 11 to to TO cord-029547-9ei1ram3 17 12 detect detect VB cord-029547-9ei1ram3 17 13 and and CC cord-029547-9ei1ram3 17 14 cure cure VB cord-029547-9ei1ram3 17 15 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 17 16 is be VBZ cord-029547-9ei1ram3 17 17 necessary necessary JJ cord-029547-9ei1ram3 17 18 for for IN cord-029547-9ei1ram3 17 19 outbreak outbreak NN cord-029547-9ei1ram3 17 20 control control NN cord-029547-9ei1ram3 17 21 . . . cord-029547-9ei1ram3 18 1 The the DT cord-029547-9ei1ram3 18 2 detection detection NN cord-029547-9ei1ram3 18 3 and and CC cord-029547-9ei1ram3 18 4 rehabilitation rehabilitation NN cord-029547-9ei1ram3 18 5 judgment judgment NN cord-029547-9ei1ram3 18 6 of of IN cord-029547-9ei1ram3 18 7 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 18 8 are be VBP cord-029547-9ei1ram3 18 9 mainly mainly RB cord-029547-9ei1ram3 18 10 through through IN cord-029547-9ei1ram3 18 11 reverse reverse JJ cord-029547-9ei1ram3 18 12 transcriptionpolymerase transcriptionpolymerase NN cord-029547-9ei1ram3 18 13 chain chain NN cord-029547-9ei1ram3 18 14 reaction reaction NN cord-029547-9ei1ram3 18 15 ( ( -LRB- cord-029547-9ei1ram3 18 16 RT RT NNP cord-029547-9ei1ram3 18 17 - - HYPH cord-029547-9ei1ram3 18 18 PCR PCR NNP cord-029547-9ei1ram3 18 19 ) ) -RRB- cord-029547-9ei1ram3 18 20 , , , cord-029547-9ei1ram3 18 21 7 7 CD cord-029547-9ei1ram3 18 22 but but CC cord-029547-9ei1ram3 18 23 experts expert NNS cord-029547-9ei1ram3 18 24 have have VBP cord-029547-9ei1ram3 18 25 pointed point VBN cord-029547-9ei1ram3 18 26 out out RP cord-029547-9ei1ram3 18 27 the the DT cord-029547-9ei1ram3 18 28 low low JJ cord-029547-9ei1ram3 18 29 sensitivity sensitivity NN cord-029547-9ei1ram3 18 30 will will MD cord-029547-9ei1ram3 18 31 lead lead VB cord-029547-9ei1ram3 18 32 to to IN cord-029547-9ei1ram3 18 33 missed miss VBN cord-029547-9ei1ram3 18 34 diagnosis diagnosis NN cord-029547-9ei1ram3 18 35 . . . cord-029547-9ei1ram3 19 1 So so RB cord-029547-9ei1ram3 19 2 a a DT cord-029547-9ei1ram3 19 3 combination combination NN cord-029547-9ei1ram3 19 4 of of IN cord-029547-9ei1ram3 19 5 RT RT NNP cord-029547-9ei1ram3 19 6 - - HYPH cord-029547-9ei1ram3 19 7 PCR PCR NNP cord-029547-9ei1ram3 19 8 and and CC cord-029547-9ei1ram3 19 9 other other JJ cord-029547-9ei1ram3 19 10 clinical clinical JJ cord-029547-9ei1ram3 19 11 features feature NNS cord-029547-9ei1ram3 19 12 of of IN cord-029547-9ei1ram3 19 13 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 19 14 is be VBZ cord-029547-9ei1ram3 19 15 important important JJ cord-029547-9ei1ram3 19 16 for for IN cord-029547-9ei1ram3 19 17 diagnosis diagnosis NN cord-029547-9ei1ram3 19 18 . . . cord-029547-9ei1ram3 20 1 8 8 CD cord-029547-9ei1ram3 21 1 The the DT cord-029547-9ei1ram3 21 2 treatments treatment NNS cord-029547-9ei1ram3 21 3 for for IN cord-029547-9ei1ram3 21 4 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 21 5 are be VBP cord-029547-9ei1ram3 21 6 still still RB cord-029547-9ei1ram3 21 7 unclear unclear JJ cord-029547-9ei1ram3 21 8 and and CC cord-029547-9ei1ram3 21 9 mainly mainly RB cord-029547-9ei1ram3 21 10 contain contain VBP cord-029547-9ei1ram3 21 11 administration administration NN cord-029547-9ei1ram3 21 12 of of IN cord-029547-9ei1ram3 21 13 oxygen oxygen NN cord-029547-9ei1ram3 21 14 , , , cord-029547-9ei1ram3 21 15 drug drug NN cord-029547-9ei1ram3 21 16 therapy therapy NN cord-029547-9ei1ram3 21 17 , , , cord-029547-9ei1ram3 21 18 and and CC cord-029547-9ei1ram3 21 19 emergency emergency NN cord-029547-9ei1ram3 21 20 treatments treatment NNS cord-029547-9ei1ram3 21 21 such such JJ cord-029547-9ei1ram3 21 22 as as IN cord-029547-9ei1ram3 21 23 ECMO ECMO NNP cord-029547-9ei1ram3 21 24 . . . cord-029547-9ei1ram3 22 1 9 9 CD cord-029547-9ei1ram3 22 2 , , , cord-029547-9ei1ram3 22 3 10 10 CD cord-029547-9ei1ram3 23 1 As as IN cord-029547-9ei1ram3 23 2 we -PRON- PRP cord-029547-9ei1ram3 23 3 know know VBP cord-029547-9ei1ram3 23 4 , , , cord-029547-9ei1ram3 23 5 few few JJ cord-029547-9ei1ram3 23 6 studies study NNS cord-029547-9ei1ram3 23 7 have have VBP cord-029547-9ei1ram3 23 8 summarized summarize VBN cord-029547-9ei1ram3 23 9 and and CC cord-029547-9ei1ram3 23 10 classified classified JJ cord-029547-9ei1ram3 23 11 therapies therapy NNS cord-029547-9ei1ram3 23 12 for for IN cord-029547-9ei1ram3 23 13 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 23 14 systematically systematically RB cord-029547-9ei1ram3 23 15 . . . cord-029547-9ei1ram3 24 1 Therefore therefore RB cord-029547-9ei1ram3 24 2 , , , cord-029547-9ei1ram3 24 3 we -PRON- PRP cord-029547-9ei1ram3 24 4 review review VBP cord-029547-9ei1ram3 24 5 basic basic JJ cord-029547-9ei1ram3 24 6 characteristics characteristic NNS cord-029547-9ei1ram3 24 7 such such JJ cord-029547-9ei1ram3 24 8 as as IN cord-029547-9ei1ram3 24 9 virology virology NN cord-029547-9ei1ram3 24 10 and and CC cord-029547-9ei1ram3 24 11 epidemiology epidemiology NN cord-029547-9ei1ram3 24 12 of of IN cord-029547-9ei1ram3 24 13 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 24 14 and and CC cord-029547-9ei1ram3 24 15 classified classify VBN cord-029547-9ei1ram3 24 16 explore explore VB cord-029547-9ei1ram3 24 17 antiviral antiviral JJ cord-029547-9ei1ram3 24 18 therapy therapy NN cord-029547-9ei1ram3 24 19 , , , cord-029547-9ei1ram3 24 20 symptomatic symptomatic JJ cord-029547-9ei1ram3 24 21 treatment treatment NN cord-029547-9ei1ram3 24 22 , , , cord-029547-9ei1ram3 24 23 and and CC cord-029547-9ei1ram3 24 24 traditional traditional JJ cord-029547-9ei1ram3 24 25 Chinese chinese JJ cord-029547-9ei1ram3 24 26 medicines medicine NNS cord-029547-9ei1ram3 24 27 for for IN cord-029547-9ei1ram3 24 28 curing cure VBG cord-029547-9ei1ram3 24 29 COVID-19 covid-19 CD cord-029547-9ei1ram3 24 30 . . . cord-029547-9ei1ram3 25 1 Considering consider VBG cord-029547-9ei1ram3 25 2 no no DT cord-029547-9ei1ram3 25 3 licensed licensed JJ cord-029547-9ei1ram3 25 4 vaccine vaccine NN cord-029547-9ei1ram3 25 5 exists exist VBZ cord-029547-9ei1ram3 25 6 for for IN cord-029547-9ei1ram3 25 7 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 25 8 , , , cord-029547-9ei1ram3 25 9 we -PRON- PRP cord-029547-9ei1ram3 25 10 also also RB cord-029547-9ei1ram3 25 11 summarize summarize VBP cord-029547-9ei1ram3 25 12 the the DT cord-029547-9ei1ram3 25 13 research research NN cord-029547-9ei1ram3 25 14 and and CC cord-029547-9ei1ram3 25 15 development development NN cord-029547-9ei1ram3 25 16 of of IN cord-029547-9ei1ram3 25 17 its -PRON- PRP$ cord-029547-9ei1ram3 25 18 vaccine vaccine NN cord-029547-9ei1ram3 25 19 . . . cord-029547-9ei1ram3 26 1 Notice notice VB cord-029547-9ei1ram3 26 2 that that IN cord-029547-9ei1ram3 26 3 the the DT cord-029547-9ei1ram3 26 4 recent recent JJ cord-029547-9ei1ram3 26 5 emergence emergence NN cord-029547-9ei1ram3 26 6 of of IN cord-029547-9ei1ram3 26 7 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 26 8 carriers carrier NNS cord-029547-9ei1ram3 26 9 has have VBZ cord-029547-9ei1ram3 26 10 brought bring VBN cord-029547-9ei1ram3 26 11 great great JJ cord-029547-9ei1ram3 26 12 difficulties difficulty NNS cord-029547-9ei1ram3 26 13 for for IN cord-029547-9ei1ram3 26 14 prevention prevention NN cord-029547-9ei1ram3 26 15 and and CC cord-029547-9ei1ram3 26 16 control control NN cord-029547-9ei1ram3 26 17 of of IN cord-029547-9ei1ram3 26 18 this this DT cord-029547-9ei1ram3 26 19 disease disease NN cord-029547-9ei1ram3 26 20 , , , cord-029547-9ei1ram3 26 21 11 11 CD cord-029547-9ei1ram3 26 22 we -PRON- PRP cord-029547-9ei1ram3 26 23 highlight highlight VBP cord-029547-9ei1ram3 26 24 the the DT cord-029547-9ei1ram3 26 25 characteristics characteristic NNS cord-029547-9ei1ram3 26 26 of of IN cord-029547-9ei1ram3 26 27 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 26 28 carriers carrier NNS cord-029547-9ei1ram3 26 29 and and CC cord-029547-9ei1ram3 26 30 how how WRB cord-029547-9ei1ram3 26 31 to to TO cord-029547-9ei1ram3 26 32 reduce reduce VB cord-029547-9ei1ram3 26 33 their -PRON- PRP$ cord-029547-9ei1ram3 26 34 impact impact NN cord-029547-9ei1ram3 26 35 on on IN cord-029547-9ei1ram3 26 36 the the DT cord-029547-9ei1ram3 26 37 development development NN cord-029547-9ei1ram3 26 38 of of IN cord-029547-9ei1ram3 26 39 the the DT cord-029547-9ei1ram3 26 40 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 26 41 pandemic pandemic NN cord-029547-9ei1ram3 26 42 . . . cord-029547-9ei1ram3 27 1 In in IN cord-029547-9ei1ram3 27 2 January January NNP cord-029547-9ei1ram3 27 3 2020 2020 CD cord-029547-9ei1ram3 27 4 , , , cord-029547-9ei1ram3 27 5 after after IN cord-029547-9ei1ram3 27 6 the the DT cord-029547-9ei1ram3 27 7 outbreak outbreak NN cord-029547-9ei1ram3 27 8 of of IN cord-029547-9ei1ram3 27 9 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 27 10 , , , cord-029547-9ei1ram3 27 11 scientists scientist NNS cord-029547-9ei1ram3 27 12 identified identify VBD cord-029547-9ei1ram3 27 13 its -PRON- PRP$ cord-029547-9ei1ram3 27 14 pathogen pathogen NN cord-029547-9ei1ram3 27 15 and and CC cord-029547-9ei1ram3 27 16 immediately immediately RB cord-029547-9ei1ram3 27 17 confirmed confirm VBD cord-029547-9ei1ram3 27 18 it -PRON- PRP cord-029547-9ei1ram3 27 19 to to TO cord-029547-9ei1ram3 27 20 be be VB cord-029547-9ei1ram3 27 21 a a DT cord-029547-9ei1ram3 27 22 novel novel JJ cord-029547-9ei1ram3 27 23 coronavirus coronavirus NN cord-029547-9ei1ram3 27 24 , , , cord-029547-9ei1ram3 27 25 which which WDT cord-029547-9ei1ram3 27 26 is be VBZ cord-029547-9ei1ram3 27 27 found find VBN cord-029547-9ei1ram3 27 28 to to TO cord-029547-9ei1ram3 27 29 be be VB cord-029547-9ei1ram3 27 30 a a DT cord-029547-9ei1ram3 27 31 β β NN cord-029547-9ei1ram3 27 32 coronavirus coronavirus NN cord-029547-9ei1ram3 27 33 of of IN cord-029547-9ei1ram3 27 34 group group NN cord-029547-9ei1ram3 27 35 2B 2b CD cord-029547-9ei1ram3 27 36 and and CC cord-029547-9ei1ram3 27 37 was be VBD cord-029547-9ei1ram3 27 38 named name VBN cord-029547-9ei1ram3 27 39 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 27 40 by by IN cord-029547-9ei1ram3 27 41 WHO who WP cord-029547-9ei1ram3 27 42 initially initially RB cord-029547-9ei1ram3 27 43 . . . cord-029547-9ei1ram3 28 1 2 2 LS cord-029547-9ei1ram3 28 2 Because because IN cord-029547-9ei1ram3 28 3 70 70 CD cord-029547-9ei1ram3 28 4 % % NN cord-029547-9ei1ram3 28 5 of of IN cord-029547-9ei1ram3 28 6 its -PRON- PRP$ cord-029547-9ei1ram3 28 7 genetic genetic JJ cord-029547-9ei1ram3 28 8 sequences sequence NNS cord-029547-9ei1ram3 28 9 are be VBP cord-029547-9ei1ram3 28 10 similar similar JJ cord-029547-9ei1ram3 28 11 to to IN cord-029547-9ei1ram3 28 12 the the DT cord-029547-9ei1ram3 28 13 SARS SARS NNP cord-029547-9ei1ram3 28 14 - - HYPH cord-029547-9ei1ram3 28 15 CoV CoV NNP cord-029547-9ei1ram3 28 16 , , , cord-029547-9ei1ram3 28 17 it -PRON- PRP cord-029547-9ei1ram3 28 18 was be VBD cord-029547-9ei1ram3 28 19 later later RB cord-029547-9ei1ram3 28 20 renamed rename VBN cord-029547-9ei1ram3 28 21 SARS SARS NNP cord-029547-9ei1ram3 28 22 - - HYPH cord-029547-9ei1ram3 28 23 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 28 24 . . . cord-029547-9ei1ram3 29 1 12 12 CD cord-029547-9ei1ram3 30 1 The the DT cord-029547-9ei1ram3 30 2 origin origin NN cord-029547-9ei1ram3 30 3 of of IN cord-029547-9ei1ram3 30 4 SARS SARS NNP cord-029547-9ei1ram3 30 5 - - HYPH cord-029547-9ei1ram3 30 6 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 30 7 is be VBZ cord-029547-9ei1ram3 30 8 unclear unclear JJ cord-029547-9ei1ram3 30 9 and and CC cord-029547-9ei1ram3 30 10 is be VBZ cord-029547-9ei1ram3 30 11 thought think VBN cord-029547-9ei1ram3 30 12 to to TO cord-029547-9ei1ram3 30 13 be be VB cord-029547-9ei1ram3 30 14 related relate VBN cord-029547-9ei1ram3 30 15 to to IN cord-029547-9ei1ram3 30 16 bat bat NN cord-029547-9ei1ram3 30 17 coronaviruses coronaviruse NNS cord-029547-9ei1ram3 30 18 . . . cord-029547-9ei1ram3 31 1 Zhou Zhou NNP cord-029547-9ei1ram3 31 2 et et NNP cord-029547-9ei1ram3 31 3 al al NNP cord-029547-9ei1ram3 31 4 . . . cord-029547-9ei1ram3 32 1 compared compare VBN cord-029547-9ei1ram3 32 2 gene gene NN cord-029547-9ei1ram3 32 3 sequence sequence NN cord-029547-9ei1ram3 32 4 of of IN cord-029547-9ei1ram3 32 5 SARS SARS NNP cord-029547-9ei1ram3 32 6 - - HYPH cord-029547-9ei1ram3 32 7 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 32 8 with with IN cord-029547-9ei1ram3 32 9 RaTG13 RaTG13 NNP cord-029547-9ei1ram3 32 10 , , , cord-029547-9ei1ram3 32 11 a a DT cord-029547-9ei1ram3 32 12 bat bat NN cord-029547-9ei1ram3 32 13 coronavirus coronavirus NN cord-029547-9ei1ram3 32 14 , , , cord-029547-9ei1ram3 32 15 and and CC cord-029547-9ei1ram3 32 16 found find VBD cord-029547-9ei1ram3 32 17 the the DT cord-029547-9ei1ram3 32 18 whole whole JJ cord-029547-9ei1ram3 32 19 - - HYPH cord-029547-9ei1ram3 32 20 genome genome NN cord-029547-9ei1ram3 32 21 sequence sequence NN cord-029547-9ei1ram3 32 22 of of IN cord-029547-9ei1ram3 32 23 SARS SARS NNP cord-029547-9ei1ram3 32 24 - - HYPH cord-029547-9ei1ram3 32 25 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 32 26 is be VBZ cord-029547-9ei1ram3 32 27 96.2 96.2 CD cord-029547-9ei1ram3 32 28 % % NN cord-029547-9ei1ram3 32 29 similar similar JJ cord-029547-9ei1ram3 32 30 to to IN cord-029547-9ei1ram3 32 31 RaTG13 RaTG13 NNP cord-029547-9ei1ram3 32 32 , , , cord-029547-9ei1ram3 32 33 indicating indicate VBG cord-029547-9ei1ram3 32 34 that that IN cord-029547-9ei1ram3 32 35 SARS SARS NNP cord-029547-9ei1ram3 32 36 - - HYPH cord-029547-9ei1ram3 32 37 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 32 38 may may MD cord-029547-9ei1ram3 32 39 originate originate VB cord-029547-9ei1ram3 32 40 from from IN cord-029547-9ei1ram3 32 41 a a DT cord-029547-9ei1ram3 32 42 bat bat NN cord-029547-9ei1ram3 32 43 coronavirus coronavirus NN cord-029547-9ei1ram3 32 44 . . . cord-029547-9ei1ram3 33 1 13 13 CD cord-029547-9ei1ram3 34 1 At at IN cord-029547-9ei1ram3 34 2 the the DT cord-029547-9ei1ram3 34 3 same same JJ cord-029547-9ei1ram3 34 4 time time NN cord-029547-9ei1ram3 34 5 , , , cord-029547-9ei1ram3 34 6 Wu Wu NNP cord-029547-9ei1ram3 34 7 and and CC cord-029547-9ei1ram3 34 8 colleagues colleague NNS cord-029547-9ei1ram3 34 9 reported report VBD cord-029547-9ei1ram3 34 10 that that IN cord-029547-9ei1ram3 34 11 the the DT cord-029547-9ei1ram3 34 12 genome genome NN cord-029547-9ei1ram3 34 13 sequence sequence NN cord-029547-9ei1ram3 34 14 of of IN cord-029547-9ei1ram3 34 15 SARS SARS NNP cord-029547-9ei1ram3 34 16 - - HYPH cord-029547-9ei1ram3 34 17 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 34 18 was be VBD cord-029547-9ei1ram3 34 19 closely closely RB cord-029547-9ei1ram3 34 20 linked link VBN cord-029547-9ei1ram3 34 21 with with IN cord-029547-9ei1ram3 34 22 SL SL NNP cord-029547-9ei1ram3 34 23 - - HYPH cord-029547-9ei1ram3 34 24 CoVZC45 CoVZC45 NNP cord-029547-9ei1ram3 34 25 , , , cord-029547-9ei1ram3 34 26 another another DT cord-029547-9ei1ram3 34 27 bat bat NN cord-029547-9ei1ram3 34 28 coronavirus coronavirus NN cord-029547-9ei1ram3 34 29 , , , cord-029547-9ei1ram3 34 30 with with IN cord-029547-9ei1ram3 34 31 82.3 82.3 CD cord-029547-9ei1ram3 34 32 % % NN cord-029547-9ei1ram3 34 33 similarity similarity NN cord-029547-9ei1ram3 34 34 . . . cord-029547-9ei1ram3 35 1 14 14 CD cord-029547-9ei1ram3 36 1 However however RB cord-029547-9ei1ram3 36 2 , , , cord-029547-9ei1ram3 36 3 despite despite IN cord-029547-9ei1ram3 36 4 the the DT cord-029547-9ei1ram3 36 5 high high JJ cord-029547-9ei1ram3 36 6 similarity similarity NN cord-029547-9ei1ram3 36 7 of of IN cord-029547-9ei1ram3 36 8 SARS SARS NNP cord-029547-9ei1ram3 36 9 - - HYPH cord-029547-9ei1ram3 36 10 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 36 11 to to IN cord-029547-9ei1ram3 36 12 the the DT cord-029547-9ei1ram3 36 13 virus virus NN cord-029547-9ei1ram3 36 14 from from IN cord-029547-9ei1ram3 36 15 bats bat NNS cord-029547-9ei1ram3 36 16 , , , cord-029547-9ei1ram3 36 17 the the DT cord-029547-9ei1ram3 36 18 genetic genetic JJ cord-029547-9ei1ram3 36 19 differences difference NNS cord-029547-9ei1ram3 36 20 will will MD cord-029547-9ei1ram3 36 21 take take VB cord-029547-9ei1ram3 36 22 at at RB cord-029547-9ei1ram3 36 23 least least JJS cord-029547-9ei1ram3 36 24 a a DT cord-029547-9ei1ram3 36 25 few few JJ cord-029547-9ei1ram3 36 26 decades decade NNS cord-029547-9ei1ram3 36 27 of of IN cord-029547-9ei1ram3 36 28 evolution evolution NN cord-029547-9ei1ram3 36 29 to to TO cord-029547-9ei1ram3 36 30 make make VB cord-029547-9ei1ram3 36 31 up up RP cord-029547-9ei1ram3 36 32 . . . cord-029547-9ei1ram3 37 1 15 15 CD cord-029547-9ei1ram3 38 1 Thus thus RB cord-029547-9ei1ram3 38 2 , , , cord-029547-9ei1ram3 38 3 bats bat NNS cord-029547-9ei1ram3 38 4 are be VBP cord-029547-9ei1ram3 38 5 unlikely unlikely JJ cord-029547-9ei1ram3 38 6 to to TO cord-029547-9ei1ram3 38 7 be be VB cord-029547-9ei1ram3 38 8 the the DT cord-029547-9ei1ram3 38 9 definitive definitive JJ cord-029547-9ei1ram3 38 10 hosts host NNS cord-029547-9ei1ram3 38 11 of of IN cord-029547-9ei1ram3 38 12 it -PRON- PRP cord-029547-9ei1ram3 38 13 , , , cord-029547-9ei1ram3 38 14 and and CC cord-029547-9ei1ram3 38 15 there there EX cord-029547-9ei1ram3 38 16 may may MD cord-029547-9ei1ram3 38 17 exist exist VB cord-029547-9ei1ram3 38 18 other other JJ cord-029547-9ei1ram3 38 19 intermediate intermediate JJ cord-029547-9ei1ram3 38 20 hosts host NNS cord-029547-9ei1ram3 38 21 which which WDT cord-029547-9ei1ram3 38 22 brought bring VBD cord-029547-9ei1ram3 38 23 the the DT cord-029547-9ei1ram3 38 24 virus virus NN cord-029547-9ei1ram3 38 25 into into IN cord-029547-9ei1ram3 38 26 humans human NNS cord-029547-9ei1ram3 38 27 . . . cord-029547-9ei1ram3 39 1 16 16 CD cord-029547-9ei1ram3 40 1 The the DT cord-029547-9ei1ram3 40 2 relative relative JJ cord-029547-9ei1ram3 40 3 synonymous synonymous JJ cord-029547-9ei1ram3 40 4 codon codon NN cord-029547-9ei1ram3 40 5 usage usage NN cord-029547-9ei1ram3 40 6 analysis analysis NN cord-029547-9ei1ram3 40 7 of of IN cord-029547-9ei1ram3 40 8 viruses virus NNS cord-029547-9ei1ram3 40 9 found find VBD cord-029547-9ei1ram3 40 10 SARS SARS NNP cord-029547-9ei1ram3 40 11 - - HYPH cord-029547-9ei1ram3 40 12 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 40 13 used use VBD cord-029547-9ei1ram3 40 14 the the DT cord-029547-9ei1ram3 40 15 translation translation NN cord-029547-9ei1ram3 40 16 machinery machinery NN cord-029547-9ei1ram3 40 17 of of IN cord-029547-9ei1ram3 40 18 several several JJ cord-029547-9ei1ram3 40 19 snakes snake NNS cord-029547-9ei1ram3 40 20 effectively effectively RB cord-029547-9ei1ram3 40 21 . . . cord-029547-9ei1ram3 41 1 Therefore therefore RB cord-029547-9ei1ram3 41 2 , , , cord-029547-9ei1ram3 41 3 snakes snake NNS cord-029547-9ei1ram3 41 4 are be VBP cord-029547-9ei1ram3 41 5 a a DT cord-029547-9ei1ram3 41 6 potential potential JJ cord-029547-9ei1ram3 41 7 reservoir reservoir NN cord-029547-9ei1ram3 41 8 of of IN cord-029547-9ei1ram3 41 9 the the DT cord-029547-9ei1ram3 41 10 novel novel JJ cord-029547-9ei1ram3 41 11 virus virus NN cord-029547-9ei1ram3 41 12 . . . cord-029547-9ei1ram3 42 1 17 17 CD cord-029547-9ei1ram3 43 1 Apart apart RB cord-029547-9ei1ram3 43 2 from from IN cord-029547-9ei1ram3 43 3 this this DT cord-029547-9ei1ram3 43 4 , , , cord-029547-9ei1ram3 43 5 pangolins pangolin NNS cord-029547-9ei1ram3 43 6 are be VBP cord-029547-9ei1ram3 43 7 thought think VBN cord-029547-9ei1ram3 43 8 to to TO cord-029547-9ei1ram3 43 9 be be VB cord-029547-9ei1ram3 43 10 the the DT cord-029547-9ei1ram3 43 11 potential potential JJ cord-029547-9ei1ram3 43 12 intermediate intermediate JJ cord-029547-9ei1ram3 43 13 host host NN cord-029547-9ei1ram3 43 14 of of IN cord-029547-9ei1ram3 43 15 SARS SARS NNP cord-029547-9ei1ram3 43 16 - - HYPH cord-029547-9ei1ram3 43 17 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 43 18 due due IN cord-029547-9ei1ram3 43 19 to to IN cord-029547-9ei1ram3 43 20 the the DT cord-029547-9ei1ram3 43 21 sequence sequence NN cord-029547-9ei1ram3 43 22 similarity similarity NN cord-029547-9ei1ram3 43 23 of of IN cord-029547-9ei1ram3 43 24 their -PRON- PRP$ cord-029547-9ei1ram3 43 25 spike spike NN cord-029547-9ei1ram3 43 26 receptor receptor NN cord-029547-9ei1ram3 43 27 binding bind VBG cord-029547-9ei1ram3 43 28 domains domain NNS cord-029547-9ei1ram3 43 29 . . . cord-029547-9ei1ram3 44 1 18 18 CD cord-029547-9ei1ram3 45 1 Furthermore furthermore RB cord-029547-9ei1ram3 45 2 , , , cord-029547-9ei1ram3 45 3 Liu Liu NNP cord-029547-9ei1ram3 45 4 et et NNP cord-029547-9ei1ram3 45 5 al al NNP cord-029547-9ei1ram3 45 6 . . NNP cord-029547-9ei1ram3 45 7 declared declare VBD cord-029547-9ei1ram3 45 8 that that IN cord-029547-9ei1ram3 45 9 turtles turtle NNS cord-029547-9ei1ram3 45 10 were be VBD cord-029547-9ei1ram3 45 11 another another DT cord-029547-9ei1ram3 45 12 possible possible JJ cord-029547-9ei1ram3 45 13 host host NN cord-029547-9ei1ram3 45 14 of of IN cord-029547-9ei1ram3 45 15 SARS SARS NNP cord-029547-9ei1ram3 45 16 - - HYPH cord-029547-9ei1ram3 45 17 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 45 18 . . . cord-029547-9ei1ram3 46 1 19 19 CD cord-029547-9ei1ram3 47 1 Thus thus RB cord-029547-9ei1ram3 47 2 , , , cord-029547-9ei1ram3 47 3 more more JJR cord-029547-9ei1ram3 47 4 studies study NNS cord-029547-9ei1ram3 47 5 are be VBP cord-029547-9ei1ram3 47 6 necessary necessary JJ cord-029547-9ei1ram3 47 7 for for IN cord-029547-9ei1ram3 47 8 confirming confirm VBG cord-029547-9ei1ram3 47 9 the the DT cord-029547-9ei1ram3 47 10 intermediate intermediate JJ cord-029547-9ei1ram3 47 11 host host NN cord-029547-9ei1ram3 47 12 of of IN cord-029547-9ei1ram3 47 13 SARS SARS NNP cord-029547-9ei1ram3 47 14 - - HYPH cord-029547-9ei1ram3 47 15 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 47 16 . . . cord-029547-9ei1ram3 48 1 The the DT cord-029547-9ei1ram3 48 2 pathogenic pathogenic JJ cord-029547-9ei1ram3 48 3 mechanism mechanism NN cord-029547-9ei1ram3 48 4 of of IN cord-029547-9ei1ram3 48 5 SARS SARS NNP cord-029547-9ei1ram3 48 6 - - HYPH cord-029547-9ei1ram3 48 7 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 48 8 is be VBZ cord-029547-9ei1ram3 48 9 still still RB cord-029547-9ei1ram3 48 10 unclear unclear JJ cord-029547-9ei1ram3 48 11 and and CC cord-029547-9ei1ram3 48 12 thought think VBD cord-029547-9ei1ram3 48 13 to to TO cord-029547-9ei1ram3 48 14 be be VB cord-029547-9ei1ram3 48 15 closely closely RB cord-029547-9ei1ram3 48 16 related relate VBN cord-029547-9ei1ram3 48 17 to to IN cord-029547-9ei1ram3 48 18 viral viral JJ cord-029547-9ei1ram3 48 19 sepsis sepsis NN cord-029547-9ei1ram3 48 20 , , , cord-029547-9ei1ram3 48 21 20 20 CD cord-029547-9ei1ram3 48 22 but but CC cord-029547-9ei1ram3 48 23 structural structural JJ cord-029547-9ei1ram3 48 24 biology biology NN cord-029547-9ei1ram3 48 25 has have VBZ cord-029547-9ei1ram3 48 26 explained explain VBN cord-029547-9ei1ram3 48 27 how how WRB cord-029547-9ei1ram3 48 28 viruses virus NNS cord-029547-9ei1ram3 48 29 enter enter VBP cord-029547-9ei1ram3 48 30 cells cell NNS cord-029547-9ei1ram3 48 31 . . . cord-029547-9ei1ram3 49 1 Angiotensin angiotensin NN cord-029547-9ei1ram3 49 2 converting convert VBG cord-029547-9ei1ram3 49 3 enzyme enzyme NN cord-029547-9ei1ram3 49 4 II II NNP cord-029547-9ei1ram3 49 5 ( ( -LRB- cord-029547-9ei1ram3 49 6 ACE2 ACE2 NNP cord-029547-9ei1ram3 49 7 ) ) -RRB- cord-029547-9ei1ram3 49 8 has have VBZ cord-029547-9ei1ram3 49 9 been be VBN cord-029547-9ei1ram3 49 10 demonstrated demonstrate VBN cord-029547-9ei1ram3 49 11 to to TO cord-029547-9ei1ram3 49 12 be be VB cord-029547-9ei1ram3 49 13 the the DT cord-029547-9ei1ram3 49 14 only only JJ cord-029547-9ei1ram3 49 15 receptor receptor NN cord-029547-9ei1ram3 49 16 for for IN cord-029547-9ei1ram3 49 17 SARS SARS NNP cord-029547-9ei1ram3 49 18 - - HYPH cord-029547-9ei1ram3 49 19 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 49 20 . . . cord-029547-9ei1ram3 50 1 13 13 CD cord-029547-9ei1ram3 51 1 The the DT cord-029547-9ei1ram3 51 2 S S NNP cord-029547-9ei1ram3 51 3 protein protein NN cord-029547-9ei1ram3 51 4 on on IN cord-029547-9ei1ram3 51 5 the the DT cord-029547-9ei1ram3 51 6 surface surface NN cord-029547-9ei1ram3 51 7 of of IN cord-029547-9ei1ram3 51 8 coronavirus coronavirus NN cord-029547-9ei1ram3 51 9 was be VBD cord-029547-9ei1ram3 51 10 confirmed confirm VBN cord-029547-9ei1ram3 51 11 to to TO cord-029547-9ei1ram3 51 12 mediate mediate VB cord-029547-9ei1ram3 51 13 virus virus NN cord-029547-9ei1ram3 51 14 entry entry NN cord-029547-9ei1ram3 51 15 , , , cord-029547-9ei1ram3 51 16 21 21 CD cord-029547-9ei1ram3 51 17 which which WDT cord-029547-9ei1ram3 51 18 contains contain VBZ cord-029547-9ei1ram3 51 19 proteins protein NNS cord-029547-9ei1ram3 51 20 S1 S1 NNP cord-029547-9ei1ram3 51 21 and and CC cord-029547-9ei1ram3 51 22 S2 S2 NNP cord-029547-9ei1ram3 51 23 subunits subunit NNS cord-029547-9ei1ram3 51 24 . . . cord-029547-9ei1ram3 52 1 The the DT cord-029547-9ei1ram3 52 2 receptor receptor NN cord-029547-9ei1ram3 52 3 - - HYPH cord-029547-9ei1ram3 52 4 binding bind VBG cord-029547-9ei1ram3 52 5 domain domain NN cord-029547-9ei1ram3 52 6 ( ( -LRB- cord-029547-9ei1ram3 52 7 RBD RBD NNP cord-029547-9ei1ram3 52 8 ) ) -RRB- cord-029547-9ei1ram3 52 9 of of IN cord-029547-9ei1ram3 52 10 S1 S1 NNP cord-029547-9ei1ram3 52 11 is be VBZ cord-029547-9ei1ram3 52 12 responsible responsible JJ cord-029547-9ei1ram3 52 13 for for IN cord-029547-9ei1ram3 52 14 the the DT cord-029547-9ei1ram3 52 15 recognition recognition NN cord-029547-9ei1ram3 52 16 of of IN cord-029547-9ei1ram3 52 17 ACE2 ACE2 NNP cord-029547-9ei1ram3 52 18 on on IN cord-029547-9ei1ram3 52 19 the the DT cord-029547-9ei1ram3 52 20 surface surface NN cord-029547-9ei1ram3 52 21 of of IN cord-029547-9ei1ram3 52 22 human human JJ cord-029547-9ei1ram3 52 23 cells cell NNS cord-029547-9ei1ram3 52 24 to to TO cord-029547-9ei1ram3 52 25 complete complete VB cord-029547-9ei1ram3 52 26 the the DT cord-029547-9ei1ram3 52 27 binding binding NN cord-029547-9ei1ram3 52 28 of of IN cord-029547-9ei1ram3 52 29 viruses virus NNS cord-029547-9ei1ram3 52 30 to to IN cord-029547-9ei1ram3 52 31 cells cell NNS cord-029547-9ei1ram3 52 32 . . . cord-029547-9ei1ram3 53 1 The the DT cord-029547-9ei1ram3 53 2 S2 S2 NNP cord-029547-9ei1ram3 53 3 subunit subunit NN cord-029547-9ei1ram3 53 4 mediates mediate VBZ cord-029547-9ei1ram3 53 5 the the DT cord-029547-9ei1ram3 53 6 fusion fusion NN cord-029547-9ei1ram3 53 7 of of IN cord-029547-9ei1ram3 53 8 the the DT cord-029547-9ei1ram3 53 9 virus virus NN cord-029547-9ei1ram3 53 10 envelope envelope NN cord-029547-9ei1ram3 53 11 and and CC cord-029547-9ei1ram3 53 12 human human JJ cord-029547-9ei1ram3 53 13 cell cell NN cord-029547-9ei1ram3 53 14 membrane membrane NN cord-029547-9ei1ram3 53 15 to to TO cord-029547-9ei1ram3 53 16 complete complete VB cord-029547-9ei1ram3 53 17 the the DT cord-029547-9ei1ram3 53 18 invasion invasion NN cord-029547-9ei1ram3 53 19 process process NN cord-029547-9ei1ram3 53 20 . . . cord-029547-9ei1ram3 54 1 There there EX cord-029547-9ei1ram3 54 2 are be VBP cord-029547-9ei1ram3 54 3 two two CD cord-029547-9ei1ram3 54 4 important important JJ cord-029547-9ei1ram3 54 5 conserved conserve VBN cord-029547-9ei1ram3 54 6 repeated repeat VBN cord-029547-9ei1ram3 54 7 amino amino NN cord-029547-9ei1ram3 54 8 acid acid NN cord-029547-9ei1ram3 54 9 sequences sequence NNS cord-029547-9ei1ram3 54 10 , , , cord-029547-9ei1ram3 54 11 HR1 HR1 NNP cord-029547-9ei1ram3 54 12 and and CC cord-029547-9ei1ram3 54 13 HR2 HR2 NNP cord-029547-9ei1ram3 54 14 , , , cord-029547-9ei1ram3 54 15 in in IN cord-029547-9ei1ram3 54 16 the the DT cord-029547-9ei1ram3 54 17 S2 S2 NNP cord-029547-9ei1ram3 54 18 subunit subunit NN cord-029547-9ei1ram3 54 19 of of IN cord-029547-9ei1ram3 54 20 SARS SARS NNP cord-029547-9ei1ram3 54 21 - - HYPH cord-029547-9ei1ram3 54 22 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 54 23 . . . cord-029547-9ei1ram3 55 1 Together together RB cord-029547-9ei1ram3 55 2 , , , cord-029547-9ei1ram3 55 3 they -PRON- PRP cord-029547-9ei1ram3 55 4 form form VBP cord-029547-9ei1ram3 55 5 a a DT cord-029547-9ei1ram3 55 6 spiral spiral JJ cord-029547-9ei1ram3 55 7 structure structure NN cord-029547-9ei1ram3 55 8 called call VBN cord-029547-9ei1ram3 55 9 6-HB 6-hb CD cord-029547-9ei1ram3 55 10 , , , cord-029547-9ei1ram3 55 11 which which WDT cord-029547-9ei1ram3 55 12 is be VBZ cord-029547-9ei1ram3 55 13 the the DT cord-029547-9ei1ram3 55 14 key key NN cord-029547-9ei1ram3 55 15 for for IN cord-029547-9ei1ram3 55 16 the the DT cord-029547-9ei1ram3 55 17 fusion fusion NN cord-029547-9ei1ram3 55 18 of of IN cord-029547-9ei1ram3 55 19 a a DT cord-029547-9ei1ram3 55 20 coronavirus coronavirus NN cord-029547-9ei1ram3 55 21 envelope envelope NN cord-029547-9ei1ram3 55 22 with with IN cord-029547-9ei1ram3 55 23 cell cell NN cord-029547-9ei1ram3 55 24 membrane membrane NN cord-029547-9ei1ram3 55 25 . . . cord-029547-9ei1ram3 56 1 22 22 CD cord-029547-9ei1ram3 57 1 The the DT cord-029547-9ei1ram3 57 2 serine serine NN cord-029547-9ei1ram3 57 3 protease protease NN cord-029547-9ei1ram3 57 4 TMPRSS2 TMPRSS2 NNP cord-029547-9ei1ram3 57 5 triggers trigger VBZ cord-029547-9ei1ram3 57 6 the the DT cord-029547-9ei1ram3 57 7 S S NNP cord-029547-9ei1ram3 57 8 protein protein NN cord-029547-9ei1ram3 57 9 and and CC cord-029547-9ei1ram3 57 10 promotes promote VBZ cord-029547-9ei1ram3 57 11 its -PRON- PRP$ cord-029547-9ei1ram3 57 12 fusion fusion NN cord-029547-9ei1ram3 57 13 with with IN cord-029547-9ei1ram3 57 14 the the DT cord-029547-9ei1ram3 57 15 cell cell NN cord-029547-9ei1ram3 57 16 membrane membrane NN cord-029547-9ei1ram3 57 17 . . . cord-029547-9ei1ram3 58 1 23 23 CD cord-029547-9ei1ram3 59 1 After after IN cord-029547-9ei1ram3 59 2 that that DT cord-029547-9ei1ram3 59 3 , , , cord-029547-9ei1ram3 59 4 the the DT cord-029547-9ei1ram3 59 5 RNA RNA NNP cord-029547-9ei1ram3 59 6 of of IN cord-029547-9ei1ram3 59 7 the the DT cord-029547-9ei1ram3 59 8 virus virus NN cord-029547-9ei1ram3 59 9 is be VBZ cord-029547-9ei1ram3 59 10 released release VBN cord-029547-9ei1ram3 59 11 into into IN cord-029547-9ei1ram3 59 12 the the DT cord-029547-9ei1ram3 59 13 cytoplasm cytoplasm NN cord-029547-9ei1ram3 59 14 to to TO cord-029547-9ei1ram3 59 15 complete complete VB cord-029547-9ei1ram3 59 16 its -PRON- PRP$ cord-029547-9ei1ram3 59 17 biosynthesis biosynthesis NN cord-029547-9ei1ram3 59 18 . . . cord-029547-9ei1ram3 60 1 SARS SARS NNP cord-029547-9ei1ram3 60 2 - - HYPH cord-029547-9ei1ram3 60 3 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 60 4 is be VBZ cord-029547-9ei1ram3 60 5 more more RBR cord-029547-9ei1ram3 60 6 contagious contagious JJ cord-029547-9ei1ram3 60 7 , , , cord-029547-9ei1ram3 60 8 although although IN cord-029547-9ei1ram3 60 9 it -PRON- PRP cord-029547-9ei1ram3 60 10 has have VBZ cord-029547-9ei1ram3 60 11 a a DT cord-029547-9ei1ram3 60 12 similar similar JJ cord-029547-9ei1ram3 60 13 structure structure NN cord-029547-9ei1ram3 60 14 of of IN cord-029547-9ei1ram3 60 15 S s NN cord-029547-9ei1ram3 60 16 protein protein NN cord-029547-9ei1ram3 60 17 to to IN cord-029547-9ei1ram3 60 18 SARS SARS NNP cord-029547-9ei1ram3 60 19 - - HYPH cord-029547-9ei1ram3 60 20 CoV CoV NNP cord-029547-9ei1ram3 60 21 , , , cord-029547-9ei1ram3 60 22 so so IN cord-029547-9ei1ram3 60 23 virus virus NN cord-029547-9ei1ram3 60 24 - - HYPH cord-029547-9ei1ram3 60 25 receptor receptor NN cord-029547-9ei1ram3 60 26 - - HYPH cord-029547-9ei1ram3 60 27 binding bind VBG cord-029547-9ei1ram3 60 28 affinity affinity NN cord-029547-9ei1ram3 60 29 is be VBZ cord-029547-9ei1ram3 60 30 now now RB cord-029547-9ei1ram3 60 31 being be VBG cord-029547-9ei1ram3 60 32 conducted conduct VBN cord-029547-9ei1ram3 60 33 in in IN cord-029547-9ei1ram3 60 34 further further JJ cord-029547-9ei1ram3 60 35 studies study NNS cord-029547-9ei1ram3 60 36 . . . cord-029547-9ei1ram3 61 1 Goh Goh NNP cord-029547-9ei1ram3 61 2 et et NNP cord-029547-9ei1ram3 61 3 al al NNP cord-029547-9ei1ram3 61 4 . . . cord-029547-9ei1ram3 62 1 found find VBD cord-029547-9ei1ram3 62 2 the the DT cord-029547-9ei1ram3 62 3 rigidity rigidity NN cord-029547-9ei1ram3 62 4 and and CC cord-029547-9ei1ram3 62 5 stability stability NN cord-029547-9ei1ram3 62 6 of of IN cord-029547-9ei1ram3 62 7 SARS SARS NNP cord-029547-9ei1ram3 62 8 - - HYPH cord-029547-9ei1ram3 62 9 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 62 10 shell shell NN cord-029547-9ei1ram3 62 11 are be VBP cord-029547-9ei1ram3 62 12 apparently apparently RB cord-029547-9ei1ram3 62 13 higher high JJR cord-029547-9ei1ram3 62 14 than than IN cord-029547-9ei1ram3 62 15 SARS SARS NNP cord-029547-9ei1ram3 62 16 - - HYPH cord-029547-9ei1ram3 62 17 CoV CoV NNP cord-029547-9ei1ram3 62 18 , , , cord-029547-9ei1ram3 62 19 24 24 CD cord-029547-9ei1ram3 62 20 which which WDT cord-029547-9ei1ram3 62 21 increase increase VBP cord-029547-9ei1ram3 62 22 its -PRON- PRP$ cord-029547-9ei1ram3 62 23 adaption adaption NN cord-029547-9ei1ram3 62 24 to to IN cord-029547-9ei1ram3 62 25 the the DT cord-029547-9ei1ram3 62 26 environment environment NN cord-029547-9ei1ram3 62 27 . . . cord-029547-9ei1ram3 63 1 Moreover moreover RB cord-029547-9ei1ram3 63 2 , , , cord-029547-9ei1ram3 63 3 the the DT cord-029547-9ei1ram3 63 4 structural structural JJ cord-029547-9ei1ram3 63 5 difference difference NN cord-029547-9ei1ram3 63 6 of of IN cord-029547-9ei1ram3 63 7 HR1 HR1 NNP cord-029547-9ei1ram3 63 8 contributes contribute VBZ cord-029547-9ei1ram3 63 9 to to IN cord-029547-9ei1ram3 63 10 the the DT cord-029547-9ei1ram3 63 11 higher high JJR cord-029547-9ei1ram3 63 12 structural structural JJ cord-029547-9ei1ram3 63 13 stability stability NN cord-029547-9ei1ram3 63 14 for for IN cord-029547-9ei1ram3 63 15 the the DT cord-029547-9ei1ram3 63 16 6-HB 6-hb CD cord-029547-9ei1ram3 63 17 of of IN cord-029547-9ei1ram3 63 18 SARS SARS NNP cord-029547-9ei1ram3 63 19 - - HYPH cord-029547-9ei1ram3 63 20 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 63 21 , , , cord-029547-9ei1ram3 63 22 which which WDT cord-029547-9ei1ram3 63 23 has have VBZ cord-029547-9ei1ram3 63 24 caused cause VBN cord-029547-9ei1ram3 63 25 the the DT cord-029547-9ei1ram3 63 26 better well JJR cord-029547-9ei1ram3 63 27 membrane membrane NN cord-029547-9ei1ram3 63 28 fusion fusion NN cord-029547-9ei1ram3 63 29 capacity capacity NN cord-029547-9ei1ram3 63 30 of of IN cord-029547-9ei1ram3 63 31 SARS SARS NNP cord-029547-9ei1ram3 63 32 - - HYPH cord-029547-9ei1ram3 63 33 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 63 34 . . . cord-029547-9ei1ram3 64 1 22 22 CD cord-029547-9ei1ram3 65 1 Thus thus RB cord-029547-9ei1ram3 65 2 , , , cord-029547-9ei1ram3 65 3 SARS SARS NNP cord-029547-9ei1ram3 65 4 - - HYPH cord-029547-9ei1ram3 65 5 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 65 6 has have VBZ cord-029547-9ei1ram3 65 7 a a DT cord-029547-9ei1ram3 65 8 stronger strong JJR cord-029547-9ei1ram3 65 9 infectious infectious JJ cord-029547-9ei1ram3 65 10 ability ability NN cord-029547-9ei1ram3 65 11 . . . cord-029547-9ei1ram3 66 1 It -PRON- PRP cord-029547-9ei1ram3 66 2 is be VBZ cord-029547-9ei1ram3 66 3 worth worth JJ cord-029547-9ei1ram3 66 4 noting note VBG cord-029547-9ei1ram3 66 5 that that IN cord-029547-9ei1ram3 66 6 the the DT cord-029547-9ei1ram3 66 7 expressions expression NNS cord-029547-9ei1ram3 66 8 of of IN cord-029547-9ei1ram3 66 9 ACE2 ACE2 NNP cord-029547-9ei1ram3 66 10 in in IN cord-029547-9ei1ram3 66 11 patients patient NNS cord-029547-9ei1ram3 66 12 with with IN cord-029547-9ei1ram3 66 13 some some DT cord-029547-9ei1ram3 66 14 diseases disease NNS cord-029547-9ei1ram3 66 15 such such JJ cord-029547-9ei1ram3 66 16 as as IN cord-029547-9ei1ram3 66 17 diabetes diabete NNS cord-029547-9ei1ram3 66 18 are be VBP cord-029547-9ei1ram3 66 19 notably notably RB cord-029547-9ei1ram3 66 20 higher high JJR cord-029547-9ei1ram3 66 21 than than IN cord-029547-9ei1ram3 66 22 those those DT cord-029547-9ei1ram3 66 23 in in IN cord-029547-9ei1ram3 66 24 healthy healthy JJ cord-029547-9ei1ram3 66 25 people people NNS cord-029547-9ei1ram3 66 26 , , , cord-029547-9ei1ram3 66 27 25 25 CD cord-029547-9ei1ram3 66 28 indicating indicate VBG cord-029547-9ei1ram3 66 29 that that IN cord-029547-9ei1ram3 66 30 people people NNS cord-029547-9ei1ram3 66 31 with with IN cord-029547-9ei1ram3 66 32 underlying underlie VBG cord-029547-9ei1ram3 66 33 diseases disease NNS cord-029547-9ei1ram3 66 34 are be VBP cord-029547-9ei1ram3 66 35 more more RBR cord-029547-9ei1ram3 66 36 likely likely JJ cord-029547-9ei1ram3 66 37 to to TO cord-029547-9ei1ram3 66 38 be be VB cord-029547-9ei1ram3 66 39 infected infect VBN cord-029547-9ei1ram3 66 40 . . . cord-029547-9ei1ram3 67 1 On on IN cord-029547-9ei1ram3 67 2 31 31 CD cord-029547-9ei1ram3 67 3 December December NNP cord-029547-9ei1ram3 67 4 2019 2019 CD cord-029547-9ei1ram3 67 5 , , , cord-029547-9ei1ram3 67 6 Wuhan Wuhan NNP cord-029547-9ei1ram3 67 7 Municipal Municipal NNP cord-029547-9ei1ram3 67 8 Health Health NNP cord-029547-9ei1ram3 67 9 Commission Commission NNP cord-029547-9ei1ram3 67 10 reported report VBD cord-029547-9ei1ram3 67 11 that that IN cord-029547-9ei1ram3 67 12 27 27 CD cord-029547-9ei1ram3 67 13 pneumonia pneumonia NN cord-029547-9ei1ram3 67 14 patients patient NNS cord-029547-9ei1ram3 67 15 were be VBD cord-029547-9ei1ram3 67 16 associated associate VBN cord-029547-9ei1ram3 67 17 with with IN cord-029547-9ei1ram3 67 18 a a DT cord-029547-9ei1ram3 67 19 South South NNP cord-029547-9ei1ram3 67 20 China China NNP cord-029547-9ei1ram3 67 21 seafood seafood NN cord-029547-9ei1ram3 67 22 market market NN cord-029547-9ei1ram3 67 23 , , , cord-029547-9ei1ram3 67 24 which which WDT cord-029547-9ei1ram3 67 25 was be VBD cord-029547-9ei1ram3 67 26 the the DT cord-029547-9ei1ram3 67 27 earliest early JJS cord-029547-9ei1ram3 67 28 discovery discovery NN cord-029547-9ei1ram3 67 29 of of IN cord-029547-9ei1ram3 67 30 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 67 31 . . . cord-029547-9ei1ram3 67 32 26 26 CD cord-029547-9ei1ram3 68 1 Then then RB cord-029547-9ei1ram3 68 2 , , , cord-029547-9ei1ram3 68 3 the the DT cord-029547-9ei1ram3 68 4 quantity quantity NN cord-029547-9ei1ram3 68 5 of of IN cord-029547-9ei1ram3 68 6 COVID-19 covid-19 JJ cord-029547-9ei1ram3 68 7 patients patient NNS cord-029547-9ei1ram3 68 8 increased increase VBD cord-029547-9ei1ram3 68 9 rapidly rapidly RB cord-029547-9ei1ram3 68 10 after after IN cord-029547-9ei1ram3 68 11 Chinese Chinese NNP cord-029547-9ei1ram3 68 12 New New NNP cord-029547-9ei1ram3 68 13 Year Year NNP cord-029547-9ei1ram3 68 14 . . . cord-029547-9ei1ram3 69 1 Up up IN cord-029547-9ei1ram3 69 2 to to TO cord-029547-9ei1ram3 69 3 16 16 CD cord-029547-9ei1ram3 69 4 May May NNP cord-029547-9ei1ram3 69 5 2020 2020 CD cord-029547-9ei1ram3 69 6 , , , cord-029547-9ei1ram3 69 7 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 69 8 had have VBD cord-029547-9ei1ram3 69 9 affected affect VBN cord-029547-9ei1ram3 69 10 more more JJR cord-029547-9ei1ram3 69 11 than than IN cord-029547-9ei1ram3 69 12 200 200 CD cord-029547-9ei1ram3 69 13 countries country NNS cord-029547-9ei1ram3 69 14 and and CC cord-029547-9ei1ram3 69 15 regions region NNS cord-029547-9ei1ram3 69 16 , , , cord-029547-9ei1ram3 69 17 and and CC cord-029547-9ei1ram3 69 18 the the DT cord-029547-9ei1ram3 69 19 quantity quantity NN cord-029547-9ei1ram3 69 20 of of IN cord-029547-9ei1ram3 69 21 confirmed confirm VBN cord-029547-9ei1ram3 69 22 patients patient NNS cord-029547-9ei1ram3 69 23 had have VBD cord-029547-9ei1ram3 69 24 reached reach VBN cord-029547-9ei1ram3 69 25 4 4 CD cord-029547-9ei1ram3 69 26 425 425 CD cord-029547-9ei1ram3 69 27 485 485 CD cord-029547-9ei1ram3 69 28 globally globally RB cord-029547-9ei1ram3 69 29 . . . cord-029547-9ei1ram3 70 1 27 27 CD cord-029547-9ei1ram3 71 1 After after IN cord-029547-9ei1ram3 71 2 the the DT cord-029547-9ei1ram3 71 3 breakthrough breakthrough NN cord-029547-9ei1ram3 71 4 of of IN cord-029547-9ei1ram3 71 5 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 71 6 , , , cord-029547-9ei1ram3 71 7 experts expert NNS cord-029547-9ei1ram3 71 8 began begin VBD cord-029547-9ei1ram3 71 9 to to TO cord-029547-9ei1ram3 71 10 predict predict VB cord-029547-9ei1ram3 71 11 the the DT cord-029547-9ei1ram3 71 12 incubation incubation NN cord-029547-9ei1ram3 71 13 stage stage NN cord-029547-9ei1ram3 71 14 of of IN cord-029547-9ei1ram3 71 15 the the DT cord-029547-9ei1ram3 71 16 SARS SARS NNP cord-029547-9ei1ram3 71 17 - - HYPH cord-029547-9ei1ram3 71 18 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 71 19 . . . cord-029547-9ei1ram3 72 1 According accord VBG cord-029547-9ei1ram3 72 2 to to IN cord-029547-9ei1ram3 72 3 the the DT cord-029547-9ei1ram3 72 4 data datum NNS cord-029547-9ei1ram3 72 5 collected collect VBN cord-029547-9ei1ram3 72 6 in in IN cord-029547-9ei1ram3 72 7 January January NNP cord-029547-9ei1ram3 72 8 2020 2020 CD cord-029547-9ei1ram3 72 9 , , , cord-029547-9ei1ram3 72 10 the the DT cord-029547-9ei1ram3 72 11 incubation incubation NN cord-029547-9ei1ram3 72 12 stage stage NN cord-029547-9ei1ram3 72 13 of of IN cord-029547-9ei1ram3 72 14 COVID-19 covid-19 JJ cord-029547-9ei1ram3 72 15 patients patient NNS cord-029547-9ei1ram3 72 16 ranges range VBZ cord-029547-9ei1ram3 72 17 between between IN cord-029547-9ei1ram3 72 18 2 2 CD cord-029547-9ei1ram3 72 19 and and CC cord-029547-9ei1ram3 72 20 14 14 CD cord-029547-9ei1ram3 72 21 days day NNS cord-029547-9ei1ram3 72 22 , , , cord-029547-9ei1ram3 72 23 and and CC cord-029547-9ei1ram3 72 24 its -PRON- PRP$ cord-029547-9ei1ram3 72 25 average average NN cord-029547-9ei1ram3 72 26 is be VBZ cord-029547-9ei1ram3 72 27 about about RB cord-029547-9ei1ram3 72 28 5 5 CD cord-029547-9ei1ram3 72 29 days day NNS cord-029547-9ei1ram3 72 30 ( ( -LRB- cord-029547-9ei1ram3 72 31 95 95 CD cord-029547-9ei1ram3 72 32 % % NN cord-029547-9ei1ram3 72 33 credible credible JJ cord-029547-9ei1ram3 72 34 interval interval NN cord-029547-9ei1ram3 72 35 : : : cord-029547-9ei1ram3 72 36 4.2 4.2 CD cord-029547-9ei1ram3 72 37 - - HYPH cord-029547-9ei1ram3 72 38 6.0 6.0 CD cord-029547-9ei1ram3 72 39 ) ) -RRB- cord-029547-9ei1ram3 72 40 when when WRB cord-029547-9ei1ram3 72 41 implementing implement VBG cord-029547-9ei1ram3 72 42 the the DT cord-029547-9ei1ram3 72 43 best well RBS cord-029547-9ei1ram3 72 44 - - HYPH cord-029547-9ei1ram3 72 45 fit fit JJ cord-029547-9ei1ram3 72 46 lognormal lognormal JJ cord-029547-9ei1ram3 72 47 distribution distribution NN cord-029547-9ei1ram3 72 48 . . . cord-029547-9ei1ram3 73 1 Thus thus RB cord-029547-9ei1ram3 73 2 , , , cord-029547-9ei1ram3 73 3 experts expert NNS cord-029547-9ei1ram3 73 4 recommended recommend VBD cord-029547-9ei1ram3 73 5 that that IN cord-029547-9ei1ram3 73 6 suspected suspect VBN cord-029547-9ei1ram3 73 7 patients patient NNS cord-029547-9ei1ram3 73 8 are be VBP cord-029547-9ei1ram3 73 9 quarantined quarantine VBN cord-029547-9ei1ram3 73 10 for for IN cord-029547-9ei1ram3 73 11 at at RB cord-029547-9ei1ram3 73 12 least least RBS cord-029547-9ei1ram3 73 13 14 14 CD cord-029547-9ei1ram3 73 14 days day NNS cord-029547-9ei1ram3 73 15 . . . cord-029547-9ei1ram3 74 1 28 28 CD cord-029547-9ei1ram3 75 1 The the DT cord-029547-9ei1ram3 75 2 mode mode NN cord-029547-9ei1ram3 75 3 of of IN cord-029547-9ei1ram3 75 4 SARS SARS NNP cord-029547-9ei1ram3 75 5 - - HYPH cord-029547-9ei1ram3 75 6 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 75 7 transmission transmission NN cord-029547-9ei1ram3 75 8 is be VBZ cord-029547-9ei1ram3 75 9 also also RB cord-029547-9ei1ram3 75 10 an an DT cord-029547-9ei1ram3 75 11 important important JJ cord-029547-9ei1ram3 75 12 part part NN cord-029547-9ei1ram3 75 13 of of IN cord-029547-9ei1ram3 75 14 epidemiological epidemiological JJ cord-029547-9ei1ram3 75 15 investigation investigation NN cord-029547-9ei1ram3 75 16 . . . cord-029547-9ei1ram3 76 1 It -PRON- PRP cord-029547-9ei1ram3 76 2 is be VBZ cord-029547-9ei1ram3 76 3 clear clear JJ cord-029547-9ei1ram3 76 4 that that IN cord-029547-9ei1ram3 76 5 humanto humanto JJ cord-029547-9ei1ram3 76 6 - - HYPH cord-029547-9ei1ram3 76 7 human human JJ cord-029547-9ei1ram3 76 8 transmission transmission NN cord-029547-9ei1ram3 76 9 of of IN cord-029547-9ei1ram3 76 10 COVID-19 covid-19 NN cord-029547-9ei1ram3 76 11 occurs occur VBZ cord-029547-9ei1ram3 76 12 mainly mainly RB cord-029547-9ei1ram3 76 13 via via IN cord-029547-9ei1ram3 76 14 droplet droplet NN cord-029547-9ei1ram3 76 15 respiratory respiratory JJ cord-029547-9ei1ram3 76 16 particles particle NNS cord-029547-9ei1ram3 76 17 , , , cord-029547-9ei1ram3 76 18 29 29 CD cord-029547-9ei1ram3 76 19 but but CC cord-029547-9ei1ram3 76 20 whether whether IN cord-029547-9ei1ram3 76 21 SARS SARS NNP cord-029547-9ei1ram3 76 22 - - HYPH cord-029547-9ei1ram3 76 23 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 76 24 can can MD cord-029547-9ei1ram3 76 25 be be VB cord-029547-9ei1ram3 76 26 transmitted transmit VBN cord-029547-9ei1ram3 76 27 via via IN cord-029547-9ei1ram3 76 28 the the DT cord-029547-9ei1ram3 76 29 eyes eye NNS cord-029547-9ei1ram3 76 30 is be VBZ cord-029547-9ei1ram3 76 31 still still RB cord-029547-9ei1ram3 76 32 unclear unclear JJ cord-029547-9ei1ram3 76 33 . . . cord-029547-9ei1ram3 77 1 30 30 CD cord-029547-9ei1ram3 78 1 It -PRON- PRP cord-029547-9ei1ram3 78 2 should should MD cord-029547-9ei1ram3 78 3 be be VB cord-029547-9ei1ram3 78 4 noted note VBN cord-029547-9ei1ram3 78 5 that that IN cord-029547-9ei1ram3 78 6 several several JJ cord-029547-9ei1ram3 78 7 studies study NNS cord-029547-9ei1ram3 78 8 have have VBP cord-029547-9ei1ram3 78 9 showed show VBN cord-029547-9ei1ram3 78 10 that that IN cord-029547-9ei1ram3 78 11 chief chief JJ cord-029547-9ei1ram3 78 12 complaint complaint NN cord-029547-9ei1ram3 78 13 of of IN cord-029547-9ei1ram3 78 14 some some DT cord-029547-9ei1ram3 78 15 COVID-19 covid-19 JJ cord-029547-9ei1ram3 78 16 patients patient NNS cord-029547-9ei1ram3 78 17 were be VBD cord-029547-9ei1ram3 78 18 digestive digestive JJ cord-029547-9ei1ram3 78 19 symptoms symptom NNS cord-029547-9ei1ram3 78 20 , , , cord-029547-9ei1ram3 78 21 and and CC cord-029547-9ei1ram3 78 22 nucleic nucleic JJ cord-029547-9ei1ram3 78 23 acids acid NNS cord-029547-9ei1ram3 78 24 of of IN cord-029547-9ei1ram3 78 25 SARS SARS NNP cord-029547-9ei1ram3 78 26 - - HYPH cord-029547-9ei1ram3 78 27 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 78 28 were be VBD cord-029547-9ei1ram3 78 29 even even RB cord-029547-9ei1ram3 78 30 found find VBN cord-029547-9ei1ram3 78 31 in in IN cord-029547-9ei1ram3 78 32 fecal fecal JJ cord-029547-9ei1ram3 78 33 samples sample NNS cord-029547-9ei1ram3 78 34 or or CC cord-029547-9ei1ram3 78 35 anal anal JJ cord-029547-9ei1ram3 78 36 swabs swab NNS cord-029547-9ei1ram3 78 37 of of IN cord-029547-9ei1ram3 78 38 some some DT cord-029547-9ei1ram3 78 39 patients patient NNS cord-029547-9ei1ram3 78 40 , , , cord-029547-9ei1ram3 78 41 demonstrating demonstrate VBG cord-029547-9ei1ram3 78 42 the the DT cord-029547-9ei1ram3 78 43 possibility possibility NN cord-029547-9ei1ram3 78 44 of of IN cord-029547-9ei1ram3 78 45 an an DT cord-029547-9ei1ram3 78 46 oralfecal oralfecal JJ cord-029547-9ei1ram3 78 47 route route NN cord-029547-9ei1ram3 78 48 . . . cord-029547-9ei1ram3 79 1 [ [ -LRB- cord-029547-9ei1ram3 79 2 31 31 CD cord-029547-9ei1ram3 79 3 ] ] -RRB- cord-029547-9ei1ram3 79 4 [ [ -LRB- cord-029547-9ei1ram3 79 5 32 32 CD cord-029547-9ei1ram3 79 6 ] ] -RRB- cord-029547-9ei1ram3 79 7 [ [ -LRB- cord-029547-9ei1ram3 79 8 33 33 CD cord-029547-9ei1ram3 79 9 ] ] -RRB- cord-029547-9ei1ram3 80 1 Furthermore furthermore RB cord-029547-9ei1ram3 80 2 , , , cord-029547-9ei1ram3 80 3 mother mother NN cord-029547-9ei1ram3 80 4 - - HYPH cord-029547-9ei1ram3 80 5 to to IN cord-029547-9ei1ram3 80 6 - - HYPH cord-029547-9ei1ram3 80 7 child child NN cord-029547-9ei1ram3 80 8 transmission transmission NN cord-029547-9ei1ram3 80 9 is be VBZ cord-029547-9ei1ram3 80 10 also also RB cord-029547-9ei1ram3 80 11 a a DT cord-029547-9ei1ram3 80 12 potential potential JJ cord-029547-9ei1ram3 80 13 route route NN cord-029547-9ei1ram3 80 14 of of IN cord-029547-9ei1ram3 80 15 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 80 16 . . . cord-029547-9ei1ram3 81 1 34 34 CD cord-029547-9ei1ram3 81 2 , , , cord-029547-9ei1ram3 81 3 35 35 CD cord-029547-9ei1ram3 81 4 Luckily luckily RB cord-029547-9ei1ram3 81 5 , , , cord-029547-9ei1ram3 81 6 infection infection NN cord-029547-9ei1ram3 81 7 rates rate NNS cord-029547-9ei1ram3 81 8 of of IN cord-029547-9ei1ram3 81 9 children child NNS cord-029547-9ei1ram3 81 10 are be VBP cord-029547-9ei1ram3 81 11 relatively relatively RB cord-029547-9ei1ram3 81 12 low low JJ cord-029547-9ei1ram3 81 13 , , , cord-029547-9ei1ram3 81 14 and and CC cord-029547-9ei1ram3 81 15 most most RBS cord-029547-9ei1ram3 81 16 inpatient inpatient JJ cord-029547-9ei1ram3 81 17 children child NNS cord-029547-9ei1ram3 81 18 only only RB cord-029547-9ei1ram3 81 19 have have VBP cord-029547-9ei1ram3 81 20 mild mild JJ cord-029547-9ei1ram3 81 21 symptoms symptom NNS cord-029547-9ei1ram3 81 22 even even RB cord-029547-9ei1ram3 81 23 if if IN cord-029547-9ei1ram3 81 24 they -PRON- PRP cord-029547-9ei1ram3 81 25 are be VBP cord-029547-9ei1ram3 81 26 infected infect VBN cord-029547-9ei1ram3 81 27 , , , cord-029547-9ei1ram3 81 28 [ [ -LRB- cord-029547-9ei1ram3 81 29 36 36 CD cord-029547-9ei1ram3 81 30 ] ] -RRB- cord-029547-9ei1ram3 81 31 [ [ -LRB- cord-029547-9ei1ram3 81 32 37 37 CD cord-029547-9ei1ram3 81 33 ] ] -RRB- cord-029547-9ei1ram3 81 34 [ [ -LRB- cord-029547-9ei1ram3 81 35 38 38 CD cord-029547-9ei1ram3 81 36 ] ] -RRB- cord-029547-9ei1ram3 81 37 thus thus RB cord-029547-9ei1ram3 81 38 less less JJR cord-029547-9ei1ram3 81 39 damage damage NN cord-029547-9ei1ram3 81 40 would would MD cord-029547-9ei1ram3 81 41 occur occur VB cord-029547-9ei1ram3 81 42 to to IN cord-029547-9ei1ram3 81 43 them -PRON- PRP cord-029547-9ei1ram3 81 44 . . . cord-029547-9ei1ram3 82 1 Up up IN cord-029547-9ei1ram3 82 2 until until IN cord-029547-9ei1ram3 82 3 now now RB cord-029547-9ei1ram3 82 4 , , , cord-029547-9ei1ram3 82 5 the the DT cord-029547-9ei1ram3 82 6 largest large JJS cord-029547-9ei1ram3 82 7 case case NN cord-029547-9ei1ram3 82 8 series series NN cord-029547-9ei1ram3 82 9 data datum NNS cord-029547-9ei1ram3 82 10 of of IN cord-029547-9ei1ram3 82 11 China China NNP cord-029547-9ei1ram3 82 12 has have VBZ cord-029547-9ei1ram3 82 13 shown show VBN cord-029547-9ei1ram3 82 14 that that IN cord-029547-9ei1ram3 82 15 86.6 86.6 CD cord-029547-9ei1ram3 82 16 % % NN cord-029547-9ei1ram3 82 17 of of IN cord-029547-9ei1ram3 82 18 COVID-19 covid-19 JJ cord-029547-9ei1ram3 82 19 patients patient NNS cord-029547-9ei1ram3 82 20 were be VBD cord-029547-9ei1ram3 82 21 aged aged JJ cord-029547-9ei1ram3 82 22 30 30 CD cord-029547-9ei1ram3 82 23 - - SYM cord-029547-9ei1ram3 82 24 79 79 CD cord-029547-9ei1ram3 82 25 years year NNS cord-029547-9ei1ram3 82 26 , , , cord-029547-9ei1ram3 82 27 1 1 CD cord-029547-9ei1ram3 82 28 % % NN cord-029547-9ei1ram3 82 29 were be VBD cord-029547-9ei1ram3 82 30 aged age VBN cord-029547-9ei1ram3 82 31 under under IN cord-029547-9ei1ram3 82 32 1 1 CD cord-029547-9ei1ram3 82 33 year year NN cord-029547-9ei1ram3 82 34 old old JJ cord-029547-9ei1ram3 82 35 , , , cord-029547-9ei1ram3 82 36 1 1 CD cord-029547-9ei1ram3 82 37 % % NN cord-029547-9ei1ram3 82 38 aged age VBN cord-029547-9ei1ram3 82 39 10 10 CD cord-029547-9ei1ram3 82 40 - - SYM cord-029547-9ei1ram3 82 41 19 19 CD cord-029547-9ei1ram3 82 42 years year NNS cord-029547-9ei1ram3 82 43 , , , cord-029547-9ei1ram3 82 44 and and CC cord-029547-9ei1ram3 82 45 3 3 CD cord-029547-9ei1ram3 82 46 % % NN cord-029547-9ei1ram3 82 47 were be VBD cord-029547-9ei1ram3 82 48 aged age VBN cord-029547-9ei1ram3 82 49 above above IN cord-029547-9ei1ram3 82 50 80 80 CD cord-029547-9ei1ram3 82 51 years year NNS cord-029547-9ei1ram3 82 52 . . . cord-029547-9ei1ram3 83 1 Among among IN cord-029547-9ei1ram3 83 2 all all DT cord-029547-9ei1ram3 83 3 patients patient NNS cord-029547-9ei1ram3 83 4 , , , cord-029547-9ei1ram3 83 5 males male NNS cord-029547-9ei1ram3 83 6 account account VBP cord-029547-9ei1ram3 83 7 for for IN cord-029547-9ei1ram3 83 8 51 51 CD cord-029547-9ei1ram3 83 9 % % NN cord-029547-9ei1ram3 83 10 , , , cord-029547-9ei1ram3 83 11 and and CC cord-029547-9ei1ram3 83 12 females female NNS cord-029547-9ei1ram3 83 13 account account VBP cord-029547-9ei1ram3 83 14 for for IN cord-029547-9ei1ram3 83 15 49 49 CD cord-029547-9ei1ram3 83 16 % % NN cord-029547-9ei1ram3 83 17 . . . cord-029547-9ei1ram3 84 1 Furthermore furthermore RB cord-029547-9ei1ram3 84 2 , , , cord-029547-9ei1ram3 84 3 4 4 CD cord-029547-9ei1ram3 84 4 % % NN cord-029547-9ei1ram3 84 5 of of IN cord-029547-9ei1ram3 84 6 them -PRON- PRP cord-029547-9ei1ram3 84 7 are be VBP cord-029547-9ei1ram3 84 8 medical medical JJ cord-029547-9ei1ram3 84 9 workers worker NNS cord-029547-9ei1ram3 84 10 . . . cord-029547-9ei1ram3 85 1 39 39 CD cord-029547-9ei1ram3 86 1 In in IN cord-029547-9ei1ram3 86 2 the the DT cord-029547-9ei1ram3 86 3 United United NNP cord-029547-9ei1ram3 86 4 States States NNP cord-029547-9ei1ram3 86 5 , , , cord-029547-9ei1ram3 86 6 the the DT cord-029547-9ei1ram3 86 7 elderly elderly JJ cord-029547-9ei1ram3 86 8 ( ( -LRB- cord-029547-9ei1ram3 86 9 aged age VBN cord-029547-9ei1ram3 86 10 over over IN cord-029547-9ei1ram3 86 11 65 65 CD cord-029547-9ei1ram3 86 12 ) ) -RRB- cord-029547-9ei1ram3 86 13 account account VBP cord-029547-9ei1ram3 86 14 for for IN cord-029547-9ei1ram3 86 15 31 31 CD cord-029547-9ei1ram3 86 16 % % NN cord-029547-9ei1ram3 86 17 of of IN cord-029547-9ei1ram3 86 18 total total JJ cord-029547-9ei1ram3 86 19 COVID-19 covid-19 JJ cord-029547-9ei1ram3 86 20 cases case NNS cord-029547-9ei1ram3 86 21 , , , cord-029547-9ei1ram3 86 22 45 45 CD cord-029547-9ei1ram3 86 23 % % NN cord-029547-9ei1ram3 86 24 of of IN cord-029547-9ei1ram3 86 25 inpatients inpatient NNS cord-029547-9ei1ram3 86 26 , , , cord-029547-9ei1ram3 86 27 53 53 CD cord-029547-9ei1ram3 86 28 % % NN cord-029547-9ei1ram3 86 29 of of IN cord-029547-9ei1ram3 86 30 ICU ICU NNP cord-029547-9ei1ram3 86 31 patients patient NNS cord-029547-9ei1ram3 86 32 , , , cord-029547-9ei1ram3 86 33 and and CC cord-029547-9ei1ram3 86 34 80 80 CD cord-029547-9ei1ram3 86 35 % % NN cord-029547-9ei1ram3 86 36 of of IN cord-029547-9ei1ram3 86 37 death death NN cord-029547-9ei1ram3 86 38 cases case NNS cord-029547-9ei1ram3 86 39 . . . cord-029547-9ei1ram3 87 1 40 40 CD cord-029547-9ei1ram3 88 1 In in IN cord-029547-9ei1ram3 88 2 terms term NNS cord-029547-9ei1ram3 88 3 of of IN cord-029547-9ei1ram3 88 4 epidemiology epidemiology NN cord-029547-9ei1ram3 88 5 , , , cord-029547-9ei1ram3 88 6 the the DT cord-029547-9ei1ram3 88 7 basic basic JJ cord-029547-9ei1ram3 88 8 reproductive reproductive JJ cord-029547-9ei1ram3 88 9 number number NN cord-029547-9ei1ram3 88 10 and and CC cord-029547-9ei1ram3 88 11 mortality mortality NN cord-029547-9ei1ram3 88 12 rate rate NN cord-029547-9ei1ram3 88 13 are be VBP cord-029547-9ei1ram3 88 14 indispensable indispensable JJ cord-029547-9ei1ram3 88 15 . . . cord-029547-9ei1ram3 89 1 Basic basic JJ cord-029547-9ei1ram3 89 2 reproductive reproductive JJ cord-029547-9ei1ram3 89 3 number number NN cord-029547-9ei1ram3 89 4 ( ( -LRB- cord-029547-9ei1ram3 89 5 R0 R0 NNP cord-029547-9ei1ram3 89 6 ) ) -RRB- cord-029547-9ei1ram3 89 7 is be VBZ cord-029547-9ei1ram3 89 8 thought think VBN cord-029547-9ei1ram3 89 9 to to TO cord-029547-9ei1ram3 89 10 be be VB cord-029547-9ei1ram3 89 11 an an DT cord-029547-9ei1ram3 89 12 important important JJ cord-029547-9ei1ram3 89 13 index index NN cord-029547-9ei1ram3 89 14 for for IN cord-029547-9ei1ram3 89 15 predicting predict VBG cord-029547-9ei1ram3 89 16 the the DT cord-029547-9ei1ram3 89 17 development development NN cord-029547-9ei1ram3 89 18 of of IN cord-029547-9ei1ram3 89 19 an an DT cord-029547-9ei1ram3 89 20 outbreak outbreak NN cord-029547-9ei1ram3 89 21 . . . cord-029547-9ei1ram3 90 1 The the DT cord-029547-9ei1ram3 90 2 main main JJ cord-029547-9ei1ram3 90 3 method method NN cord-029547-9ei1ram3 90 4 of of IN cord-029547-9ei1ram3 90 5 calculating calculate VBG cord-029547-9ei1ram3 90 6 R0 R0 NNP cord-029547-9ei1ram3 90 7 is be VBZ cord-029547-9ei1ram3 90 8 using use VBG cord-029547-9ei1ram3 90 9 the the DT cord-029547-9ei1ram3 90 10 data datum NNS cord-029547-9ei1ram3 90 11 of of IN cord-029547-9ei1ram3 90 12 infected infected JJ cord-029547-9ei1ram3 90 13 people people NNS cord-029547-9ei1ram3 90 14 , , , cord-029547-9ei1ram3 90 15 such such JJ cord-029547-9ei1ram3 90 16 as as IN cord-029547-9ei1ram3 90 17 serial serial JJ cord-029547-9ei1ram3 90 18 interval interval NN cord-029547-9ei1ram3 90 19 distribution distribution NN cord-029547-9ei1ram3 90 20 and and CC cord-029547-9ei1ram3 90 21 latent latent JJ cord-029547-9ei1ram3 90 22 period period NN cord-029547-9ei1ram3 90 23 , , , cord-029547-9ei1ram3 90 24 to to TO cord-029547-9ei1ram3 90 25 build build VB cord-029547-9ei1ram3 90 26 a a DT cord-029547-9ei1ram3 90 27 proper proper JJ cord-029547-9ei1ram3 90 28 mathematical mathematical JJ cord-029547-9ei1ram3 90 29 model model NN cord-029547-9ei1ram3 90 30 for for IN cord-029547-9ei1ram3 90 31 predicting predict VBG cord-029547-9ei1ram3 90 32 the the DT cord-029547-9ei1ram3 90 33 trend trend NN cord-029547-9ei1ram3 90 34 of of IN cord-029547-9ei1ram3 90 35 the the DT cord-029547-9ei1ram3 90 36 epidemic epidemic NN cord-029547-9ei1ram3 90 37 . . . cord-029547-9ei1ram3 91 1 A a DT cord-029547-9ei1ram3 91 2 big big JJ cord-029547-9ei1ram3 91 3 epidemiological epidemiological JJ cord-029547-9ei1ram3 91 4 data datum NNS cord-029547-9ei1ram3 91 5 of of IN cord-029547-9ei1ram3 91 6 425 425 CD cord-029547-9ei1ram3 91 7 confirmed confirm VBD cord-029547-9ei1ram3 91 8 COVID-19 covid-19 CD cord-029547-9ei1ram3 91 9 patients patient NNS cord-029547-9ei1ram3 91 10 reported report VBD cord-029547-9ei1ram3 91 11 that that IN cord-029547-9ei1ram3 91 12 the the DT cord-029547-9ei1ram3 91 13 basic basic JJ cord-029547-9ei1ram3 91 14 reproductive reproductive JJ cord-029547-9ei1ram3 91 15 number number NN cord-029547-9ei1ram3 91 16 of of IN cord-029547-9ei1ram3 91 17 SARS SARS NNP cord-029547-9ei1ram3 91 18 - - HYPH cord-029547-9ei1ram3 91 19 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 91 20 was be VBD cord-029547-9ei1ram3 91 21 2.2 2.2 CD cord-029547-9ei1ram3 91 22 , , , cord-029547-9ei1ram3 91 23 which which WDT cord-029547-9ei1ram3 91 24 means mean VBZ cord-029547-9ei1ram3 91 25 each each DT cord-029547-9ei1ram3 91 26 patient patient NN cord-029547-9ei1ram3 91 27 could could MD cord-029547-9ei1ram3 91 28 infect infect VB cord-029547-9ei1ram3 91 29 2.2 2.2 CD cord-029547-9ei1ram3 91 30 other other JJ cord-029547-9ei1ram3 91 31 people people NNS cord-029547-9ei1ram3 91 32 . . . cord-029547-9ei1ram3 92 1 1 1 LS cord-029547-9ei1ram3 93 1 However however RB cord-029547-9ei1ram3 93 2 , , , cord-029547-9ei1ram3 93 3 more more RBR cord-029547-9ei1ram3 93 4 recent recent JJ cord-029547-9ei1ram3 93 5 research research NN cord-029547-9ei1ram3 93 6 estimated estimate VBD cord-029547-9ei1ram3 93 7 that that IN cord-029547-9ei1ram3 93 8 basic basic JJ cord-029547-9ei1ram3 93 9 reproductive reproductive JJ cord-029547-9ei1ram3 93 10 number number NN cord-029547-9ei1ram3 93 11 was be VBD cord-029547-9ei1ram3 93 12 5.8 5.8 CD cord-029547-9ei1ram3 93 13 . . . cord-029547-9ei1ram3 94 1 41 41 CD cord-029547-9ei1ram3 95 1 It -PRON- PRP cord-029547-9ei1ram3 95 2 is be VBZ cord-029547-9ei1ram3 95 3 obvious obvious JJ cord-029547-9ei1ram3 95 4 that that IN cord-029547-9ei1ram3 95 5 distinctions distinction NNS cord-029547-9ei1ram3 95 6 of of IN cord-029547-9ei1ram3 95 7 R0 R0 NNP cord-029547-9ei1ram3 95 8 exist exist VBP cord-029547-9ei1ram3 95 9 in in IN cord-029547-9ei1ram3 95 10 these these DT cord-029547-9ei1ram3 95 11 studies study NNS cord-029547-9ei1ram3 95 12 , , , cord-029547-9ei1ram3 95 13 and and CC cord-029547-9ei1ram3 95 14 they -PRON- PRP cord-029547-9ei1ram3 95 15 result result VBP cord-029547-9ei1ram3 95 16 in in IN cord-029547-9ei1ram3 95 17 data datum NNS cord-029547-9ei1ram3 95 18 and and CC cord-029547-9ei1ram3 95 19 model model NN cord-029547-9ei1ram3 95 20 differences difference NNS cord-029547-9ei1ram3 95 21 . . . cord-029547-9ei1ram3 96 1 The the DT cord-029547-9ei1ram3 96 2 incubation incubation NN cord-029547-9ei1ram3 96 3 period period NN cord-029547-9ei1ram3 96 4 and and CC cord-029547-9ei1ram3 96 5 serial serial JJ cord-029547-9ei1ram3 96 6 interval interval NN cord-029547-9ei1ram3 96 7 distribution distribution NN cord-029547-9ei1ram3 96 8 of of IN cord-029547-9ei1ram3 96 9 former former JJ cord-029547-9ei1ram3 96 10 research research NN cord-029547-9ei1ram3 96 11 are be VBP cord-029547-9ei1ram3 96 12 calculated calculate VBN cord-029547-9ei1ram3 96 13 only only RB cord-029547-9ei1ram3 96 14 through through IN cord-029547-9ei1ram3 96 15 10 10 CD cord-029547-9ei1ram3 96 16 confirmed confirm VBN cord-029547-9ei1ram3 96 17 cases case NNS cord-029547-9ei1ram3 96 18 and and CC cord-029547-9ei1ram3 96 19 six six CD cord-029547-9ei1ram3 96 20 pairs pair NNS cord-029547-9ei1ram3 96 21 of of IN cord-029547-9ei1ram3 96 22 cases case NNS cord-029547-9ei1ram3 96 23 in in IN cord-029547-9ei1ram3 96 24 clusters cluster NNS cord-029547-9ei1ram3 96 25 , , , cord-029547-9ei1ram3 96 26 respectively respectively RB cord-029547-9ei1ram3 96 27 . . . cord-029547-9ei1ram3 97 1 1 1 LS cord-029547-9ei1ram3 98 1 Furthermore furthermore RB cord-029547-9ei1ram3 98 2 , , , cord-029547-9ei1ram3 98 3 the the DT cord-029547-9ei1ram3 98 4 model model NN cord-029547-9ei1ram3 98 5 of of IN cord-029547-9ei1ram3 98 6 the the DT cord-029547-9ei1ram3 98 7 former former JJ cord-029547-9ei1ram3 98 8 research research NN cord-029547-9ei1ram3 98 9 is be VBZ cord-029547-9ei1ram3 98 10 made make VBN cord-029547-9ei1ram3 98 11 merely merely RB cord-029547-9ei1ram3 98 12 on on IN cord-029547-9ei1ram3 98 13 the the DT cord-029547-9ei1ram3 98 14 basis basis NN cord-029547-9ei1ram3 98 15 of of IN cord-029547-9ei1ram3 98 16 one one CD cord-029547-9ei1ram3 98 17 region region NN cord-029547-9ei1ram3 98 18 , , , cord-029547-9ei1ram3 98 19 1 1 CD cord-029547-9ei1ram3 98 20 thus thus RB cord-029547-9ei1ram3 98 21 its -PRON- PRP$ cord-029547-9ei1ram3 98 22 R0 R0 NNP cord-029547-9ei1ram3 98 23 distinctly distinctly RB cord-029547-9ei1ram3 98 24 lacks lack VBZ cord-029547-9ei1ram3 98 25 universality universality NN cord-029547-9ei1ram3 98 26 . . . cord-029547-9ei1ram3 99 1 By by IN cord-029547-9ei1ram3 99 2 contrast contrast NN cord-029547-9ei1ram3 99 3 , , , cord-029547-9ei1ram3 99 4 the the DT cord-029547-9ei1ram3 99 5 latter latter JJ cord-029547-9ei1ram3 99 6 study study NN cord-029547-9ei1ram3 99 7 gathered gather VBD cord-029547-9ei1ram3 99 8 the the DT cord-029547-9ei1ram3 99 9 information information NN cord-029547-9ei1ram3 99 10 of of IN cord-029547-9ei1ram3 99 11 incubation incubation NN cord-029547-9ei1ram3 99 12 period period NN cord-029547-9ei1ram3 99 13 , , , cord-029547-9ei1ram3 99 14 serial serial JJ cord-029547-9ei1ram3 99 15 interval interval NN cord-029547-9ei1ram3 99 16 , , , cord-029547-9ei1ram3 99 17 and and CC cord-029547-9ei1ram3 99 18 infectious infectious JJ cord-029547-9ei1ram3 99 19 period period NN cord-029547-9ei1ram3 99 20 from from IN cord-029547-9ei1ram3 99 21 the the DT cord-029547-9ei1ram3 99 22 individual individual JJ cord-029547-9ei1ram3 99 23 cases case NNS cord-029547-9ei1ram3 99 24 reported report VBN cord-029547-9ei1ram3 99 25 throughout throughout IN cord-029547-9ei1ram3 99 26 China China NNP cord-029547-9ei1ram3 99 27 and and CC cord-029547-9ei1ram3 99 28 designed design VBD cord-029547-9ei1ram3 99 29 two two CD cord-029547-9ei1ram3 99 30 models model NNS cord-029547-9ei1ram3 99 31 to to TO cord-029547-9ei1ram3 99 32 infer infer VB cord-029547-9ei1ram3 99 33 the the DT cord-029547-9ei1ram3 99 34 growth growth NN cord-029547-9ei1ram3 99 35 rate rate NN cord-029547-9ei1ram3 99 36 of of IN cord-029547-9ei1ram3 99 37 the the DT cord-029547-9ei1ram3 99 38 outbreak outbreak NN cord-029547-9ei1ram3 99 39 in in IN cord-029547-9ei1ram3 99 40 different different JJ cord-029547-9ei1ram3 99 41 perspectives perspective NNS cord-029547-9ei1ram3 99 42 . . . cord-029547-9ei1ram3 100 1 41 41 CD cord-029547-9ei1ram3 101 1 So so RB cord-029547-9ei1ram3 101 2 , , , cord-029547-9ei1ram3 101 3 its -PRON- PRP$ cord-029547-9ei1ram3 101 4 R0 R0 NNP cord-029547-9ei1ram3 101 5 better well RBR cord-029547-9ei1ram3 101 6 reflects reflect VBZ cord-029547-9ei1ram3 101 7 the the DT cord-029547-9ei1ram3 101 8 epidemic epidemic NN cord-029547-9ei1ram3 101 9 situation situation NN cord-029547-9ei1ram3 101 10 of of IN cord-029547-9ei1ram3 101 11 China China NNP cord-029547-9ei1ram3 101 12 . . . cord-029547-9ei1ram3 102 1 Similarly similarly RB cord-029547-9ei1ram3 102 2 , , , cord-029547-9ei1ram3 102 3 the the DT cord-029547-9ei1ram3 102 4 R0 R0 NNP cord-029547-9ei1ram3 102 5 of of IN cord-029547-9ei1ram3 102 6 around around RB cord-029547-9ei1ram3 102 7 3.87 3.87 CD cord-029547-9ei1ram3 102 8 reported report VBN cord-029547-9ei1ram3 102 9 by by IN cord-029547-9ei1ram3 102 10 Imperial Imperial NNP cord-029547-9ei1ram3 102 11 College College NNP cord-029547-9ei1ram3 102 12 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 102 13 Response Response NNP cord-029547-9ei1ram3 102 14 Team Team NNP cord-029547-9ei1ram3 102 15 only only RB cord-029547-9ei1ram3 102 16 represented represent VBD cord-029547-9ei1ram3 102 17 the the DT cord-029547-9ei1ram3 102 18 situation situation NN cord-029547-9ei1ram3 102 19 in in IN cord-029547-9ei1ram3 102 20 Europe Europe NNP cord-029547-9ei1ram3 102 21 . . . cord-029547-9ei1ram3 103 1 42 42 CD cord-029547-9ei1ram3 104 1 According accord VBG cord-029547-9ei1ram3 104 2 to to IN cord-029547-9ei1ram3 104 3 the the DT cord-029547-9ei1ram3 104 4 data data NN cord-029547-9ei1ram3 104 5 analysis analysis NN cord-029547-9ei1ram3 104 6 of of IN cord-029547-9ei1ram3 104 7 the the DT cord-029547-9ei1ram3 104 8 Chinese Chinese NNP cord-029547-9ei1ram3 104 9 Center Center NNP cord-029547-9ei1ram3 104 10 for for IN cord-029547-9ei1ram3 104 11 Disease Disease NNP cord-029547-9ei1ram3 104 12 Control Control NNP cord-029547-9ei1ram3 104 13 and and CC cord-029547-9ei1ram3 104 14 Prevention Prevention NNP cord-029547-9ei1ram3 104 15 , , , cord-029547-9ei1ram3 104 16 the the DT cord-029547-9ei1ram3 104 17 overall overall JJ cord-029547-9ei1ram3 104 18 mortality mortality NN cord-029547-9ei1ram3 104 19 of of IN cord-029547-9ei1ram3 104 20 COVID-19 covid-19 JJ cord-029547-9ei1ram3 104 21 patients patient NNS cord-029547-9ei1ram3 104 22 was be VBD cord-029547-9ei1ram3 104 23 approximately approximately RB cord-029547-9ei1ram3 104 24 2.3 2.3 CD cord-029547-9ei1ram3 104 25 % % NN cord-029547-9ei1ram3 104 26 , , , cord-029547-9ei1ram3 104 27 43 43 CD cord-029547-9ei1ram3 104 28 which which WDT cord-029547-9ei1ram3 104 29 is be VBZ cord-029547-9ei1ram3 104 30 obviously obviously RB cord-029547-9ei1ram3 104 31 lower low JJR cord-029547-9ei1ram3 104 32 than than IN cord-029547-9ei1ram3 104 33 Severe severe JJ cord-029547-9ei1ram3 104 34 Acute acute JJ cord-029547-9ei1ram3 104 35 Respiratory Respiratory NNP cord-029547-9ei1ram3 104 36 Syndrome Syndrome NNP cord-029547-9ei1ram3 104 37 ( ( -LRB- cord-029547-9ei1ram3 104 38 SARS SARS NNP cord-029547-9ei1ram3 104 39 ) ) -RRB- cord-029547-9ei1ram3 104 40 and and CC cord-029547-9ei1ram3 104 41 Middle Middle NNP cord-029547-9ei1ram3 104 42 East East NNP cord-029547-9ei1ram3 104 43 Respiratory Respiratory NNP cord-029547-9ei1ram3 104 44 Syndrome Syndrome NNP cord-029547-9ei1ram3 104 45 ( ( -LRB- cord-029547-9ei1ram3 104 46 MERS MERS NNP cord-029547-9ei1ram3 104 47 ) ) -RRB- cord-029547-9ei1ram3 104 48 . . . cord-029547-9ei1ram3 105 1 44 44 CD cord-029547-9ei1ram3 106 1 However however RB cord-029547-9ei1ram3 106 2 , , , cord-029547-9ei1ram3 106 3 because because IN cord-029547-9ei1ram3 106 4 of of IN cord-029547-9ei1ram3 106 5 the the DT cord-029547-9ei1ram3 106 6 lager lager NN cord-029547-9ei1ram3 106 7 quantity quantity NN cord-029547-9ei1ram3 106 8 of of IN cord-029547-9ei1ram3 106 9 COVID-19 covid-19 JJ cord-029547-9ei1ram3 106 10 patients patient NNS cord-029547-9ei1ram3 106 11 , , , cord-029547-9ei1ram3 106 12 the the DT cord-029547-9ei1ram3 106 13 number number NN cord-029547-9ei1ram3 106 14 of of IN cord-029547-9ei1ram3 106 15 COVID-19 covid-19 JJ cord-029547-9ei1ram3 106 16 deaths death NNS cord-029547-9ei1ram3 106 17 is be VBZ cord-029547-9ei1ram3 106 18 still still RB cord-029547-9ei1ram3 106 19 high high JJ cord-029547-9ei1ram3 106 20 . . . cord-029547-9ei1ram3 107 1 Furthermore furthermore RB cord-029547-9ei1ram3 107 2 , , , cord-029547-9ei1ram3 107 3 the the DT cord-029547-9ei1ram3 107 4 data datum NNS cord-029547-9ei1ram3 107 5 from from IN cord-029547-9ei1ram3 107 6 the the DT cord-029547-9ei1ram3 107 7 epidemic epidemic NN cord-029547-9ei1ram3 107 8 area area NN cord-029547-9ei1ram3 107 9 indicated indicate VBD cord-029547-9ei1ram3 107 10 that that IN cord-029547-9ei1ram3 107 11 people people NNS cord-029547-9ei1ram3 107 12 aged aged JJ cord-029547-9ei1ram3 107 13 30 30 CD cord-029547-9ei1ram3 107 14 - - SYM cord-029547-9ei1ram3 107 15 59 59 CD cord-029547-9ei1ram3 107 16 years year NNS cord-029547-9ei1ram3 107 17 had have VBD cord-029547-9ei1ram3 107 18 the the DT cord-029547-9ei1ram3 107 19 highest high JJS cord-029547-9ei1ram3 107 20 death death NN cord-029547-9ei1ram3 107 21 rate rate NN cord-029547-9ei1ram3 107 22 of of IN cord-029547-9ei1ram3 107 23 any any DT cord-029547-9ei1ram3 107 24 age age NN cord-029547-9ei1ram3 107 25 group group NN cord-029547-9ei1ram3 107 26 , , , cord-029547-9ei1ram3 107 27 and and CC cord-029547-9ei1ram3 107 28 the the DT cord-029547-9ei1ram3 107 29 risk risk NN cord-029547-9ei1ram3 107 30 of of IN cord-029547-9ei1ram3 107 31 symptomatic symptomatic JJ cord-029547-9ei1ram3 107 32 infection infection NN cord-029547-9ei1ram3 107 33 increased increase VBN cord-029547-9ei1ram3 107 34 year year NN cord-029547-9ei1ram3 107 35 by by IN cord-029547-9ei1ram3 107 36 year year NN cord-029547-9ei1ram3 107 37 . . . cord-029547-9ei1ram3 108 1 45 45 CD cord-029547-9ei1ram3 108 2 _SP cord-029547-9ei1ram3 109 1 Like like IN cord-029547-9ei1ram3 109 2 most most JJS cord-029547-9ei1ram3 109 3 respiratory respiratory JJ cord-029547-9ei1ram3 109 4 illnesses illness NNS cord-029547-9ei1ram3 109 5 , , , cord-029547-9ei1ram3 109 6 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 109 7 has have VBZ cord-029547-9ei1ram3 109 8 many many JJ cord-029547-9ei1ram3 109 9 typical typical JJ cord-029547-9ei1ram3 109 10 respiratory respiratory JJ cord-029547-9ei1ram3 109 11 clinical clinical JJ cord-029547-9ei1ram3 109 12 symptoms symptom NNS cord-029547-9ei1ram3 109 13 . . . cord-029547-9ei1ram3 110 1 Data datum NNS cord-029547-9ei1ram3 110 2 from from IN cord-029547-9ei1ram3 110 3 1099 1099 CD cord-029547-9ei1ram3 110 4 confirmed confirm VBN cord-029547-9ei1ram3 111 1 COVID-19 covid-19 JJ cord-029547-9ei1ram3 111 2 patients patient NNS cord-029547-9ei1ram3 111 3 have have VBP cord-029547-9ei1ram3 111 4 shown show VBN cord-029547-9ei1ram3 111 5 that that IN cord-029547-9ei1ram3 111 6 88.7 88.7 CD cord-029547-9ei1ram3 111 7 % % NN cord-029547-9ei1ram3 111 8 had have VBD cord-029547-9ei1ram3 111 9 a a DT cord-029547-9ei1ram3 111 10 fever fever NN cord-029547-9ei1ram3 111 11 , , , cord-029547-9ei1ram3 111 12 67.8 67.8 CD cord-029547-9ei1ram3 111 13 % % NN cord-029547-9ei1ram3 111 14 developed develop VBD cord-029547-9ei1ram3 111 15 a a DT cord-029547-9ei1ram3 111 16 cough cough NN cord-029547-9ei1ram3 111 17 , , , cord-029547-9ei1ram3 111 18 and and CC cord-029547-9ei1ram3 111 19 2.3 2.3 CD cord-029547-9ei1ram3 111 20 % % NN cord-029547-9ei1ram3 111 21 received receive VBD cord-029547-9ei1ram3 111 22 invasive invasive JJ cord-029547-9ei1ram3 111 23 mechanical mechanical JJ cord-029547-9ei1ram3 111 24 ventilation ventilation NN cord-029547-9ei1ram3 111 25 , , , cord-029547-9ei1ram3 111 26 46 46 CD cord-029547-9ei1ram3 111 27 which which WDT cord-029547-9ei1ram3 111 28 is be VBZ cord-029547-9ei1ram3 111 29 consistent consistent JJ cord-029547-9ei1ram3 111 30 with with IN cord-029547-9ei1ram3 111 31 other other JJ cord-029547-9ei1ram3 111 32 studies study NNS cord-029547-9ei1ram3 111 33 . . . cord-029547-9ei1ram3 112 1 47 47 CD cord-029547-9ei1ram3 113 1 For for IN cord-029547-9ei1ram3 113 2 some some DT cord-029547-9ei1ram3 113 3 severe severe JJ cord-029547-9ei1ram3 113 4 patients patient NNS cord-029547-9ei1ram3 113 5 , , , cord-029547-9ei1ram3 113 6 acute acute JJ cord-029547-9ei1ram3 113 7 respiratory respiratory JJ cord-029547-9ei1ram3 113 8 distress distress NN cord-029547-9ei1ram3 113 9 syndrome syndrome NN cord-029547-9ei1ram3 113 10 ( ( -LRB- cord-029547-9ei1ram3 113 11 ARDS ARDS NNP cord-029547-9ei1ram3 113 12 ) ) -RRB- cord-029547-9ei1ram3 113 13 , , , cord-029547-9ei1ram3 113 14 shock shock NN cord-029547-9ei1ram3 113 15 , , , cord-029547-9ei1ram3 113 16 and and CC cord-029547-9ei1ram3 113 17 arrhythmia arrhythmia NN cord-029547-9ei1ram3 113 18 are be VBP cord-029547-9ei1ram3 113 19 common common JJ cord-029547-9ei1ram3 113 20 complications complication NNS cord-029547-9ei1ram3 113 21 . . . cord-029547-9ei1ram3 114 1 48 48 CD cord-029547-9ei1ram3 115 1 , , , cord-029547-9ei1ram3 115 2 49 49 CD cord-029547-9ei1ram3 115 3 Apart apart RB cord-029547-9ei1ram3 115 4 from from IN cord-029547-9ei1ram3 115 5 these these DT cord-029547-9ei1ram3 115 6 symptoms symptom NNS cord-029547-9ei1ram3 115 7 , , , cord-029547-9ei1ram3 115 8 COVID-19 covid-19 VBP cord-029547-9ei1ram3 115 9 patients patient NNS cord-029547-9ei1ram3 115 10 sometimes sometimes RB cord-029547-9ei1ram3 115 11 have have VBP cord-029547-9ei1ram3 115 12 other other JJ cord-029547-9ei1ram3 115 13 non non JJ cord-029547-9ei1ram3 115 14 - - JJ cord-029547-9ei1ram3 115 15 respiratory respiratory JJ cord-029547-9ei1ram3 115 16 symptoms symptom NNS cord-029547-9ei1ram3 115 17 such such JJ cord-029547-9ei1ram3 115 18 as as IN cord-029547-9ei1ram3 115 19 fatigue fatigue NN cord-029547-9ei1ram3 115 20 , , , cord-029547-9ei1ram3 115 21 myalgia myalgia NN cord-029547-9ei1ram3 115 22 , , , cord-029547-9ei1ram3 115 23 headache headache NN cord-029547-9ei1ram3 115 24 , , , cord-029547-9ei1ram3 115 25 and and CC cord-029547-9ei1ram3 115 26 digestive digestive JJ cord-029547-9ei1ram3 115 27 tract tract NN cord-029547-9ei1ram3 115 28 symptoms symptom NNS cord-029547-9ei1ram3 115 29 . . . cord-029547-9ei1ram3 116 1 48 48 CD cord-029547-9ei1ram3 116 2 , , , cord-029547-9ei1ram3 116 3 50 50 CD cord-029547-9ei1ram3 117 1 Moreover moreover RB cord-029547-9ei1ram3 117 2 , , , cord-029547-9ei1ram3 117 3 the the DT cord-029547-9ei1ram3 117 4 main main JJ cord-029547-9ei1ram3 117 5 changes change NNS cord-029547-9ei1ram3 117 6 in in IN cord-029547-9ei1ram3 117 7 laboratory laboratory NN cord-029547-9ei1ram3 117 8 results result NNS cord-029547-9ei1ram3 117 9 of of IN cord-029547-9ei1ram3 117 10 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 117 11 are be VBP cord-029547-9ei1ram3 117 12 decreases decrease NNS cord-029547-9ei1ram3 117 13 in in IN cord-029547-9ei1ram3 117 14 lymphocytes lymphocyte NNS cord-029547-9ei1ram3 117 15 and and CC cord-029547-9ei1ram3 117 16 eosinophils eosinophil NNS cord-029547-9ei1ram3 117 17 as as RB cord-029547-9ei1ram3 117 18 well well RB cord-029547-9ei1ram3 117 19 as as IN cord-029547-9ei1ram3 117 20 increases increase NNS cord-029547-9ei1ram3 117 21 in in IN cord-029547-9ei1ram3 117 22 D d NN cord-029547-9ei1ram3 117 23 - - HYPH cord-029547-9ei1ram3 117 24 dimer dimer NN cord-029547-9ei1ram3 117 25 , , , cord-029547-9ei1ram3 117 26 C C NNP cord-029547-9ei1ram3 117 27 - - HYPH cord-029547-9ei1ram3 117 28 reactive reactive JJ cord-029547-9ei1ram3 117 29 protein protein NN cord-029547-9ei1ram3 117 30 , , , cord-029547-9ei1ram3 117 31 prothrombin prothrombin JJ cord-029547-9ei1ram3 117 32 time time NN cord-029547-9ei1ram3 117 33 , , , cord-029547-9ei1ram3 117 34 and and CC cord-029547-9ei1ram3 117 35 procalcitonin procalcitonin NNS cord-029547-9ei1ram3 117 36 . . . cord-029547-9ei1ram3 118 1 48 48 CD cord-029547-9ei1ram3 118 2 , , , cord-029547-9ei1ram3 118 3 51 51 CD cord-029547-9ei1ram3 118 4 Computed compute VBN cord-029547-9ei1ram3 118 5 tomography tomography NN cord-029547-9ei1ram3 118 6 ( ( -LRB- cord-029547-9ei1ram3 118 7 CT CT NNP cord-029547-9ei1ram3 118 8 ) ) -RRB- cord-029547-9ei1ram3 118 9 is be VBZ cord-029547-9ei1ram3 118 10 one one CD cord-029547-9ei1ram3 118 11 of of IN cord-029547-9ei1ram3 118 12 the the DT cord-029547-9ei1ram3 118 13 most most RBS cord-029547-9ei1ram3 118 14 efficient efficient JJ cord-029547-9ei1ram3 118 15 techniques technique NNS cord-029547-9ei1ram3 118 16 for for IN cord-029547-9ei1ram3 118 17 evaluating evaluate VBG cord-029547-9ei1ram3 118 18 severity severity NN cord-029547-9ei1ram3 118 19 and and CC cord-029547-9ei1ram3 118 20 differential differential JJ cord-029547-9ei1ram3 118 21 diagnosis diagnosis NN cord-029547-9ei1ram3 118 22 of of IN cord-029547-9ei1ram3 118 23 pulmonary pulmonary JJ cord-029547-9ei1ram3 118 24 diseases disease NNS cord-029547-9ei1ram3 118 25 , , , cord-029547-9ei1ram3 118 26 thus thus RB cord-029547-9ei1ram3 118 27 the the DT cord-029547-9ei1ram3 118 28 CT CT NNP cord-029547-9ei1ram3 118 29 characteristics characteristic NNS cord-029547-9ei1ram3 118 30 ( ( -LRB- cord-029547-9ei1ram3 118 31 Fig Fig NNP cord-029547-9ei1ram3 118 32 . . . cord-029547-9ei1ram3 118 33 1 1 CD cord-029547-9ei1ram3 118 34 ) ) -RRB- cord-029547-9ei1ram3 118 35 of of IN cord-029547-9ei1ram3 118 36 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 118 37 are be VBP cord-029547-9ei1ram3 118 38 another another DT cord-029547-9ei1ram3 118 39 important important JJ cord-029547-9ei1ram3 118 40 clinical clinical JJ cord-029547-9ei1ram3 118 41 feature feature NN cord-029547-9ei1ram3 118 42 . . . cord-029547-9ei1ram3 119 1 This this DT cord-029547-9ei1ram3 119 2 clinical clinical JJ cord-029547-9ei1ram3 119 3 evidence evidence NN cord-029547-9ei1ram3 119 4 indicates indicate VBZ cord-029547-9ei1ram3 119 5 that that IN cord-029547-9ei1ram3 119 6 ground ground NN cord-029547-9ei1ram3 119 7 glass glass NN cord-029547-9ei1ram3 119 8 opacity opacity NN cord-029547-9ei1ram3 119 9 ( ( -LRB- cord-029547-9ei1ram3 119 10 GGO GGO NNP cord-029547-9ei1ram3 119 11 ) ) -RRB- cord-029547-9ei1ram3 119 12 , , , cord-029547-9ei1ram3 119 13 consolidation consolidation NN cord-029547-9ei1ram3 119 14 , , , cord-029547-9ei1ram3 119 15 and and CC cord-029547-9ei1ram3 119 16 interlobular interlobular JJ cord-029547-9ei1ram3 119 17 septal septal JJ cord-029547-9ei1ram3 119 18 thickening thickening NN cord-029547-9ei1ram3 119 19 are be VBP cord-029547-9ei1ram3 119 20 the the DT cord-029547-9ei1ram3 119 21 most most RBS cord-029547-9ei1ram3 119 22 common common JJ cord-029547-9ei1ram3 119 23 CT CT NNP cord-029547-9ei1ram3 119 24 characteristics characteristic NNS cord-029547-9ei1ram3 119 25 of of IN cord-029547-9ei1ram3 119 26 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 119 27 , , , cord-029547-9ei1ram3 119 28 which which WDT cord-029547-9ei1ram3 119 29 occurs occur VBZ cord-029547-9ei1ram3 119 30 mainly mainly RB cord-029547-9ei1ram3 119 31 in in IN cord-029547-9ei1ram3 119 32 the the DT cord-029547-9ei1ram3 119 33 posterior posterior JJ cord-029547-9ei1ram3 119 34 lung lung NN cord-029547-9ei1ram3 119 35 area area NN cord-029547-9ei1ram3 119 36 and and CC cord-029547-9ei1ram3 119 37 middle middle JJ cord-029547-9ei1ram3 119 38 and and CC cord-029547-9ei1ram3 119 39 lower low JJR cord-029547-9ei1ram3 119 40 lung lung NN cord-029547-9ei1ram3 119 41 regions region NNS cord-029547-9ei1ram3 119 42 . . . cord-029547-9ei1ram3 120 1 52 52 CD cord-029547-9ei1ram3 120 2 , , , cord-029547-9ei1ram3 120 3 53 53 CD cord-029547-9ei1ram3 121 1 Compared compare VBN cord-029547-9ei1ram3 121 2 to to IN cord-029547-9ei1ram3 121 3 patients patient NNS cord-029547-9ei1ram3 121 4 with with IN cord-029547-9ei1ram3 121 5 mild mild JJ cord-029547-9ei1ram3 121 6 symptoms symptom NNS cord-029547-9ei1ram3 121 7 , , , cord-029547-9ei1ram3 121 8 signs sign NNS cord-029547-9ei1ram3 121 9 such such JJ cord-029547-9ei1ram3 121 10 as as IN cord-029547-9ei1ram3 121 11 consolidation consolidation NN cord-029547-9ei1ram3 121 12 , , , cord-029547-9ei1ram3 121 13 thickened thicken VBD cord-029547-9ei1ram3 121 14 bronchial bronchial JJ cord-029547-9ei1ram3 121 15 wall wall NN cord-029547-9ei1ram3 121 16 , , , cord-029547-9ei1ram3 121 17 linear linear NNP cord-029547-9ei1ram3 121 18 opacities opacity NNS cord-029547-9ei1ram3 121 19 , , , cord-029547-9ei1ram3 121 20 extrapulmonary extrapulmonary JJ cord-029547-9ei1ram3 121 21 lesions lesion NNS cord-029547-9ei1ram3 121 22 , , , cord-029547-9ei1ram3 121 23 and and CC cord-029547-9ei1ram3 121 24 higher high JJR cord-029547-9ei1ram3 121 25 CT CT NNP cord-029547-9ei1ram3 121 26 scores score NNS cord-029547-9ei1ram3 121 27 are be VBP cord-029547-9ei1ram3 121 28 marked mark VBN cord-029547-9ei1ram3 121 29 CT CT NNP cord-029547-9ei1ram3 121 30 features feature NNS cord-029547-9ei1ram3 121 31 of of IN cord-029547-9ei1ram3 121 32 critically critically RB cord-029547-9ei1ram3 121 33 ill ill JJ cord-029547-9ei1ram3 121 34 patients patient NNS cord-029547-9ei1ram3 121 35 . . . cord-029547-9ei1ram3 122 1 54 54 CD cord-029547-9ei1ram3 123 1 Therefore therefore RB cord-029547-9ei1ram3 123 2 , , , cord-029547-9ei1ram3 123 3 CT CT NNP cord-029547-9ei1ram3 123 4 is be VBZ cord-029547-9ei1ram3 123 5 potentially potentially RB cord-029547-9ei1ram3 123 6 used use VBN cord-029547-9ei1ram3 123 7 to to TO cord-029547-9ei1ram3 123 8 diagnose diagnose VB cord-029547-9ei1ram3 123 9 and and CC cord-029547-9ei1ram3 123 10 predict predict VB cord-029547-9ei1ram3 123 11 the the DT cord-029547-9ei1ram3 123 12 prognosis prognosis NN cord-029547-9ei1ram3 123 13 of of IN cord-029547-9ei1ram3 123 14 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 123 15 patients patient NNS cord-029547-9ei1ram3 123 16 . . . cord-029547-9ei1ram3 124 1 Clinical clinical JJ cord-029547-9ei1ram3 124 2 symptoms symptom NNS cord-029547-9ei1ram3 124 3 are be VBP cord-029547-9ei1ram3 124 4 often often RB cord-029547-9ei1ram3 124 5 used use VBN cord-029547-9ei1ram3 124 6 as as IN cord-029547-9ei1ram3 124 7 indicators indicator NNS cord-029547-9ei1ram3 124 8 of of IN cord-029547-9ei1ram3 124 9 clinically clinically RB cord-029547-9ei1ram3 124 10 suspected suspect VBN cord-029547-9ei1ram3 124 11 cases case NNS cord-029547-9ei1ram3 124 12 . . . cord-029547-9ei1ram3 125 1 Thus thus RB cord-029547-9ei1ram3 125 2 , , , cord-029547-9ei1ram3 125 3 when when WRB cord-029547-9ei1ram3 125 4 it -PRON- PRP cord-029547-9ei1ram3 125 5 comes come VBZ cord-029547-9ei1ram3 125 6 to to IN cord-029547-9ei1ram3 125 7 the the DT cord-029547-9ei1ram3 125 8 clinical clinical JJ cord-029547-9ei1ram3 125 9 features feature NNS cord-029547-9ei1ram3 125 10 above above RB cord-029547-9ei1ram3 125 11 , , , cord-029547-9ei1ram3 125 12 it -PRON- PRP cord-029547-9ei1ram3 125 13 is be VBZ cord-029547-9ei1ram3 125 14 easy easy JJ cord-029547-9ei1ram3 125 15 to to TO cord-029547-9ei1ram3 125 16 think think VB cord-029547-9ei1ram3 125 17 about about IN cord-029547-9ei1ram3 125 18 clinical clinical JJ cord-029547-9ei1ram3 125 19 diagnosis diagnosis NN cord-029547-9ei1ram3 125 20 of of IN cord-029547-9ei1ram3 125 21 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 125 22 ( ( -LRB- cord-029547-9ei1ram3 125 23 Table table NN cord-029547-9ei1ram3 125 24 2and 2and CD cord-029547-9ei1ram3 125 25 Fig Fig NNP cord-029547-9ei1ram3 125 26 . . NNP cord-029547-9ei1ram3 125 27 2 2 CD cord-029547-9ei1ram3 125 28 ) ) -RRB- cord-029547-9ei1ram3 125 29 . . . cord-029547-9ei1ram3 126 1 According accord VBG cord-029547-9ei1ram3 126 2 to to IN cord-029547-9ei1ram3 126 3 the the DT cord-029547-9ei1ram3 126 4 Diagnosis Diagnosis NNP cord-029547-9ei1ram3 126 5 and and CC cord-029547-9ei1ram3 126 6 Treatment Treatment NNP cord-029547-9ei1ram3 126 7 Program Program NNP cord-029547-9ei1ram3 126 8 of of IN cord-029547-9ei1ram3 126 9 Novel Novel NNP cord-029547-9ei1ram3 126 10 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 126 11 Pneumonia Pneumonia NNP cord-029547-9ei1ram3 126 12 , , , cord-029547-9ei1ram3 126 13 only only RB cord-029547-9ei1ram3 126 14 a a DT cord-029547-9ei1ram3 126 15 suspected suspect VBN cord-029547-9ei1ram3 126 16 case case NN cord-029547-9ei1ram3 126 17 has have VBZ cord-029547-9ei1ram3 126 18 one one CD cord-029547-9ei1ram3 126 19 of of IN cord-029547-9ei1ram3 126 20 the the DT cord-029547-9ei1ram3 126 21 pieces piece NNS cord-029547-9ei1ram3 126 22 of of IN cord-029547-9ei1ram3 126 23 evidence evidence NN cord-029547-9ei1ram3 126 24 of of IN cord-029547-9ei1ram3 126 25 etiology etiology NN cord-029547-9ei1ram3 126 26 or or CC cord-029547-9ei1ram3 126 27 serology serology NN cord-029547-9ei1ram3 126 28 , , , cord-029547-9ei1ram3 126 29 such such JJ cord-029547-9ei1ram3 126 30 as as IN cord-029547-9ei1ram3 126 31 positive positive JJ cord-029547-9ei1ram3 126 32 nucleic nucleic JJ cord-029547-9ei1ram3 126 33 acid acid NN cord-029547-9ei1ram3 126 34 , , , cord-029547-9ei1ram3 126 35 confirmation confirmation NN cord-029547-9ei1ram3 126 36 of of IN cord-029547-9ei1ram3 126 37 gene gene NN cord-029547-9ei1ram3 126 38 sequencing sequencing NN cord-029547-9ei1ram3 126 39 , , , cord-029547-9ei1ram3 126 40 and and CC cord-029547-9ei1ram3 126 41 virus virus NN cord-029547-9ei1ram3 126 42 specific specific JJ cord-029547-9ei1ram3 126 43 antibody antibody NN cord-029547-9ei1ram3 126 44 , , , cord-029547-9ei1ram3 126 45 to to TO cord-029547-9ei1ram3 126 46 be be VB cord-029547-9ei1ram3 126 47 confirmed confirm VBN cord-029547-9ei1ram3 126 48 to to TO cord-029547-9ei1ram3 126 49 be be VB cord-029547-9ei1ram3 126 50 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 126 51 patient patient NN cord-029547-9ei1ram3 126 52 , , , cord-029547-9ei1ram3 126 53 55 55 CD cord-029547-9ei1ram3 126 54 and and CC cord-029547-9ei1ram3 126 55 the the DT cord-029547-9ei1ram3 126 56 suspected suspect VBN cord-029547-9ei1ram3 126 57 cases case NNS cord-029547-9ei1ram3 126 58 were be VBD cord-029547-9ei1ram3 126 59 identified identify VBN cord-029547-9ei1ram3 126 60 by by IN cord-029547-9ei1ram3 126 61 a a DT cord-029547-9ei1ram3 126 62 comprehensive comprehensive JJ cord-029547-9ei1ram3 126 63 analysis analysis NN cord-029547-9ei1ram3 126 64 of of IN cord-029547-9ei1ram3 126 65 epidemiological epidemiological JJ cord-029547-9ei1ram3 126 66 history history NN cord-029547-9ei1ram3 126 67 and and CC cord-029547-9ei1ram3 126 68 clinical clinical JJ cord-029547-9ei1ram3 126 69 manifestations manifestation NNS cord-029547-9ei1ram3 126 70 . . . cord-029547-9ei1ram3 127 1 56 56 CD cord-029547-9ei1ram3 128 1 However however RB cord-029547-9ei1ram3 128 2 , , , cord-029547-9ei1ram3 128 3 there there EX cord-029547-9ei1ram3 128 4 are be VBP cord-029547-9ei1ram3 128 5 also also RB cord-029547-9ei1ram3 128 6 many many JJ cord-029547-9ei1ram3 128 7 problems problem NNS cord-029547-9ei1ram3 128 8 with with IN cord-029547-9ei1ram3 128 9 this this DT cord-029547-9ei1ram3 128 10 program program NN cord-029547-9ei1ram3 128 11 . . . cord-029547-9ei1ram3 129 1 The the DT cord-029547-9ei1ram3 129 2 most most RBS cord-029547-9ei1ram3 129 3 obvious obvious JJ cord-029547-9ei1ram3 129 4 problem problem NN cord-029547-9ei1ram3 129 5 is be VBZ cord-029547-9ei1ram3 129 6 that that IN cord-029547-9ei1ram3 129 7 RT RT NNP cord-029547-9ei1ram3 129 8 - - HYPH cord-029547-9ei1ram3 129 9 PCR PCR NNP cord-029547-9ei1ram3 129 10 _SP cord-029547-9ei1ram3 129 11 Patients patient NNS cord-029547-9ei1ram3 129 12 have have VBP cord-029547-9ei1ram3 129 13 any any DT cord-029547-9ei1ram3 129 14 epidemiological epidemiological JJ cord-029547-9ei1ram3 129 15 history history NN cord-029547-9ei1ram3 129 16 and and CC cord-029547-9ei1ram3 129 17 conform conform VB cord-029547-9ei1ram3 129 18 to to IN cord-029547-9ei1ram3 129 19 at at RB cord-029547-9ei1ram3 129 20 least least RBS cord-029547-9ei1ram3 129 21 two two CD cord-029547-9ei1ram3 129 22 clinical clinical JJ cord-029547-9ei1ram3 129 23 manifestations manifestation NNS cord-029547-9ei1ram3 129 24 , , , cord-029547-9ei1ram3 129 25 or or CC cord-029547-9ei1ram3 129 26 patients patient NNS cord-029547-9ei1ram3 129 27 without without IN cord-029547-9ei1ram3 129 28 clear clear JJ cord-029547-9ei1ram3 129 29 epidemiological epidemiological JJ cord-029547-9ei1ram3 129 30 history history NN cord-029547-9ei1ram3 129 31 conform conform VBP cord-029547-9ei1ram3 129 32 to to IN cord-029547-9ei1ram3 129 33 three three CD cord-029547-9ei1ram3 129 34 clinical clinical JJ cord-029547-9ei1ram3 129 35 manifestations manifestation NNS cord-029547-9ei1ram3 129 36 . . . cord-029547-9ei1ram3 130 1 Epidemiological epidemiological JJ cord-029547-9ei1ram3 130 2 history history NN cord-029547-9ei1ram3 130 3 : : : cord-029547-9ei1ram3 131 1 I. I. NNP cord-029547-9ei1ram3 131 2 Travel Travel NNP cord-029547-9ei1ram3 131 3 or or CC cord-029547-9ei1ram3 131 4 residence residence NN cord-029547-9ei1ram3 131 5 history history NN cord-029547-9ei1ram3 131 6 of of IN cord-029547-9ei1ram3 131 7 an an DT cord-029547-9ei1ram3 131 8 affected affected JJ cord-029547-9ei1ram3 131 9 area area NN cord-029547-9ei1ram3 131 10 or or CC cord-029547-9ei1ram3 131 11 close close JJ cord-029547-9ei1ram3 131 12 contact contact NN cord-029547-9ei1ram3 131 13 with with IN cord-029547-9ei1ram3 131 14 a a DT cord-029547-9ei1ram3 131 15 suspected suspect VBN cord-029547-9ei1ram3 131 16 or or CC cord-029547-9ei1ram3 131 17 confirmed confirm VBN cord-029547-9ei1ram3 131 18 case case NN cord-029547-9ei1ram3 131 19 within within IN cord-029547-9ei1ram3 131 20 14 14 CD cord-029547-9ei1ram3 131 21 days day NNS cord-029547-9ei1ram3 131 22 before before IN cord-029547-9ei1ram3 131 23 onset onset NN cord-029547-9ei1ram3 131 24 II II NNP cord-029547-9ei1ram3 131 25 . . . cord-029547-9ei1ram3 132 1 Have have VBP cord-029547-9ei1ram3 132 2 contact contact NN cord-029547-9ei1ram3 132 3 with with IN cord-029547-9ei1ram3 132 4 COVID-19 covid-19 JJ cord-029547-9ei1ram3 132 5 cases case NNS cord-029547-9ei1ram3 132 6 ( ( -LRB- cord-029547-9ei1ram3 132 7 nucleic nucleic JJ cord-029547-9ei1ram3 132 8 acid acid NN cord-029547-9ei1ram3 132 9 positive positive JJ cord-029547-9ei1ram3 132 10 ) ) -RRB- cord-029547-9ei1ram3 132 11 within within IN cord-029547-9ei1ram3 132 12 14 14 CD cord-029547-9ei1ram3 132 13 days day NNS cord-029547-9ei1ram3 132 14 prior prior RB cord-029547-9ei1ram3 132 15 to to IN cord-029547-9ei1ram3 132 16 onset onset NN cord-029547-9ei1ram3 132 17 III III NNP cord-029547-9ei1ram3 132 18 . . . cord-029547-9ei1ram3 133 1 Have have VBP cord-029547-9ei1ram3 133 2 contact contact NN cord-029547-9ei1ram3 133 3 with with IN cord-029547-9ei1ram3 133 4 patients patient NNS cord-029547-9ei1ram3 133 5 with with IN cord-029547-9ei1ram3 133 6 fever fever NN cord-029547-9ei1ram3 133 7 or or CC cord-029547-9ei1ram3 133 8 respiratory respiratory JJ cord-029547-9ei1ram3 133 9 symptoms symptom NNS cord-029547-9ei1ram3 133 10 from from IN cord-029547-9ei1ram3 133 11 an an DT cord-029547-9ei1ram3 133 12 affected affected JJ cord-029547-9ei1ram3 133 13 area area NN cord-029547-9ei1ram3 133 14 , , , cord-029547-9ei1ram3 133 15 or or CC cord-029547-9ei1ram3 133 16 from from IN cord-029547-9ei1ram3 133 17 communities community NNS cord-029547-9ei1ram3 133 18 with with IN cord-029547-9ei1ram3 133 19 COVID-19 covid-19 JJ cord-029547-9ei1ram3 133 20 cases case NNS cord-029547-9ei1ram3 133 21 IV IV NNP cord-029547-9ei1ram3 133 22 . . . cord-029547-9ei1ram3 134 1 Cluster cluster NN cord-029547-9ei1ram3 134 2 onset onset NN cord-029547-9ei1ram3 134 3 ( ( -LRB- cord-029547-9ei1ram3 134 4 two two CD cord-029547-9ei1ram3 134 5 or or CC cord-029547-9ei1ram3 134 6 more more JJR cord-029547-9ei1ram3 134 7 cases case NNS cord-029547-9ei1ram3 134 8 of of IN cord-029547-9ei1ram3 134 9 fever fever NN cord-029547-9ei1ram3 134 10 and/or and/or CC cord-029547-9ei1ram3 134 11 respiratory respiratory JJ cord-029547-9ei1ram3 134 12 symptoms symptom NNS cord-029547-9ei1ram3 134 13 within within IN cord-029547-9ei1ram3 134 14 2 2 CD cord-029547-9ei1ram3 134 15 weeks week NNS cord-029547-9ei1ram3 134 16 in in IN cord-029547-9ei1ram3 134 17 a a DT cord-029547-9ei1ram3 134 18 small small JJ cord-029547-9ei1ram3 134 19 area area NN cord-029547-9ei1ram3 134 20 such such JJ cord-029547-9ei1ram3 134 21 as as IN cord-029547-9ei1ram3 134 22 home home NN cord-029547-9ei1ram3 134 23 , , , cord-029547-9ei1ram3 134 24 office office NN cord-029547-9ei1ram3 134 25 , , , cord-029547-9ei1ram3 134 26 school school NN cord-029547-9ei1ram3 134 27 , , , cord-029547-9ei1ram3 134 28 and and CC cord-029547-9ei1ram3 134 29 class class NN cord-029547-9ei1ram3 134 30 ) ) -RRB- cord-029547-9ei1ram3 135 1 Clinical clinical JJ cord-029547-9ei1ram3 135 2 manifestations manifestation NNS cord-029547-9ei1ram3 135 3 : : : cord-029547-9ei1ram3 135 4 I. I. NNP cord-029547-9ei1ram3 135 5 Fever fever NN cord-029547-9ei1ram3 135 6 and/or and/or CC cord-029547-9ei1ram3 135 7 respiratory respiratory JJ cord-029547-9ei1ram3 135 8 symptoms symptom NNS cord-029547-9ei1ram3 135 9 II II NNP cord-029547-9ei1ram3 135 10 . . . cord-029547-9ei1ram3 136 1 With with IN cord-029547-9ei1ram3 136 2 COVID-19 covid-19 JJ cord-029547-9ei1ram3 136 3 imaging imaging NN cord-029547-9ei1ram3 136 4 characteristics characteristic NNS cord-029547-9ei1ram3 136 5 III III NNP cord-029547-9ei1ram3 136 6 . . . cord-029547-9ei1ram3 137 1 Normal normal JJ cord-029547-9ei1ram3 137 2 or or CC cord-029547-9ei1ram3 137 3 reduced reduced JJ cord-029547-9ei1ram3 137 4 number number NN cord-029547-9ei1ram3 137 5 of of IN cord-029547-9ei1ram3 137 6 white white JJ cord-029547-9ei1ram3 137 7 blood blood NN cord-029547-9ei1ram3 137 8 cells cell NNS cord-029547-9ei1ram3 137 9 and/or and/or CC cord-029547-9ei1ram3 137 10 lymphocytes lymphocyte NNS cord-029547-9ei1ram3 137 11 in in IN cord-029547-9ei1ram3 137 12 early early JJ cord-029547-9ei1ram3 137 13 COVID-19 covid-19 NN cord-029547-9ei1ram3 138 1 The the DT cord-029547-9ei1ram3 138 2 suspected suspect VBN cord-029547-9ei1ram3 138 3 cases case NNS cord-029547-9ei1ram3 138 4 have have VBP cord-029547-9ei1ram3 138 5 at at RB cord-029547-9ei1ram3 138 6 least least RBS cord-029547-9ei1ram3 138 7 one one CD cord-029547-9ei1ram3 138 8 of of IN cord-029547-9ei1ram3 138 9 the the DT cord-029547-9ei1ram3 138 10 following following JJ cord-029547-9ei1ram3 138 11 etiological etiological JJ cord-029547-9ei1ram3 138 12 or or CC cord-029547-9ei1ram3 138 13 serological serological JJ cord-029547-9ei1ram3 138 14 evidences evidence NNS cord-029547-9ei1ram3 138 15 . . . cord-029547-9ei1ram3 139 1 I. I. NNP cord-029547-9ei1ram3 140 1 The the DT cord-029547-9ei1ram3 140 2 real real JJ cord-029547-9ei1ram3 140 3 - - HYPH cord-029547-9ei1ram3 140 4 time time NN cord-029547-9ei1ram3 140 5 fluorescent fluorescent NN cord-029547-9ei1ram3 140 6 RT RT NNP cord-029547-9ei1ram3 140 7 - - HYPH cord-029547-9ei1ram3 140 8 PCR PCR NNP cord-029547-9ei1ram3 140 9 for for IN cord-029547-9ei1ram3 140 10 specimens specimen NNS cord-029547-9ei1ram3 140 11 with with IN cord-029547-9ei1ram3 140 12 a a DT cord-029547-9ei1ram3 140 13 positive positive JJ cord-029547-9ei1ram3 140 14 result result NN cord-029547-9ei1ram3 140 15 of of IN cord-029547-9ei1ram3 140 16 SARS SARS NNP cord-029547-9ei1ram3 140 17 - - HYPH cord-029547-9ei1ram3 140 18 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 140 19 RNA RNA NNP cord-029547-9ei1ram3 140 20 II II NNP cord-029547-9ei1ram3 140 21 . . . cord-029547-9ei1ram3 141 1 Virus virus NN cord-029547-9ei1ram3 141 2 gene gene NN cord-029547-9ei1ram3 141 3 sequences sequence NNS cord-029547-9ei1ram3 141 4 are be VBP cord-029547-9ei1ram3 141 5 highly highly RB cord-029547-9ei1ram3 141 6 homologous homologous JJ cord-029547-9ei1ram3 141 7 to to IN cord-029547-9ei1ram3 141 8 SARS SARS NNP cord-029547-9ei1ram3 141 9 - - HYPH cord-029547-9ei1ram3 141 10 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 141 11 III III NNP cord-029547-9ei1ram3 141 12 . . . cord-029547-9ei1ram3 142 1 Positive positive JJ cord-029547-9ei1ram3 142 2 SARS SARS NNP cord-029547-9ei1ram3 142 3 - - HYPH cord-029547-9ei1ram3 142 4 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 142 5 specific specific JJ cord-029547-9ei1ram3 142 6 IgM IgM NNP cord-029547-9ei1ram3 142 7 antibody antibody NNP cord-029547-9ei1ram3 142 8 and and CC cord-029547-9ei1ram3 142 9 IgG IgG NNP cord-029547-9ei1ram3 142 10 antibody antibody NN cord-029547-9ei1ram3 142 11 in in IN cord-029547-9ei1ram3 142 12 serum serum NN cord-029547-9ei1ram3 142 13 ; ; : cord-029547-9ei1ram3 142 14 the the DT cord-029547-9ei1ram3 142 15 serum serum NN cord-029547-9ei1ram3 142 16 SARS SARS NNP cord-029547-9ei1ram3 142 17 - - HYPH cord-029547-9ei1ram3 142 18 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 142 19 specific specific JJ cord-029547-9ei1ram3 142 20 IgG igg NN cord-029547-9ei1ram3 142 21 antibody antibody NN cord-029547-9ei1ram3 142 22 changes change NNS cord-029547-9ei1ram3 142 23 from from IN cord-029547-9ei1ram3 142 24 negative negative JJ cord-029547-9ei1ram3 142 25 to to IN cord-029547-9ei1ram3 142 26 positive positive JJ cord-029547-9ei1ram3 142 27 or or CC cord-029547-9ei1ram3 142 28 is be VBZ cord-029547-9ei1ram3 142 29 four four CD cord-029547-9ei1ram3 142 30 times time NNS cord-029547-9ei1ram3 142 31 higher high JJR cord-029547-9ei1ram3 142 32 in in IN cord-029547-9ei1ram3 142 33 the the DT cord-029547-9ei1ram3 142 34 recovery recovery NN cord-029547-9ei1ram3 142 35 period period NN cord-029547-9ei1ram3 142 36 than than IN cord-029547-9ei1ram3 142 37 in in IN cord-029547-9ei1ram3 142 38 the the DT cord-029547-9ei1ram3 142 39 acute acute JJ cord-029547-9ei1ram3 142 40 phase phase NN cord-029547-9ei1ram3 142 41 is be VBZ cord-029547-9ei1ram3 142 42 the the DT cord-029547-9ei1ram3 142 43 most most RBS cord-029547-9ei1ram3 142 44 common common JJ cord-029547-9ei1ram3 142 45 method method NN cord-029547-9ei1ram3 142 46 for for IN cord-029547-9ei1ram3 142 47 nucleic nucleic JJ cord-029547-9ei1ram3 142 48 acid acid NN cord-029547-9ei1ram3 142 49 testing testing NN cord-029547-9ei1ram3 142 50 , , , cord-029547-9ei1ram3 142 51 but but CC cord-029547-9ei1ram3 142 52 its -PRON- PRP$ cord-029547-9ei1ram3 142 53 sensitivity sensitivity NN cord-029547-9ei1ram3 142 54 is be VBZ cord-029547-9ei1ram3 142 55 not not RB cord-029547-9ei1ram3 142 56 as as RB cord-029547-9ei1ram3 142 57 high high JJ cord-029547-9ei1ram3 142 58 as as IN cord-029547-9ei1ram3 142 59 expected expect VBN cord-029547-9ei1ram3 142 60 , , , cord-029547-9ei1ram3 142 61 57 57 CD cord-029547-9ei1ram3 142 62 thus thus RB cord-029547-9ei1ram3 142 63 it -PRON- PRP cord-029547-9ei1ram3 142 64 possibly possibly RB cord-029547-9ei1ram3 142 65 causes cause VBZ cord-029547-9ei1ram3 142 66 misdiagnosis misdiagnosis NN cord-029547-9ei1ram3 142 67 of of IN cord-029547-9ei1ram3 142 68 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 142 69 . . . cord-029547-9ei1ram3 143 1 Furthermore furthermore RB cord-029547-9ei1ram3 143 2 , , , cord-029547-9ei1ram3 143 3 although although IN cord-029547-9ei1ram3 143 4 viral viral JJ cord-029547-9ei1ram3 143 5 gene gene NN cord-029547-9ei1ram3 143 6 sequencing sequencing NN cord-029547-9ei1ram3 143 7 is be VBZ cord-029547-9ei1ram3 143 8 an an DT cord-029547-9ei1ram3 143 9 accurate accurate JJ cord-029547-9ei1ram3 143 10 diagnostic diagnostic JJ cord-029547-9ei1ram3 143 11 method method NN cord-029547-9ei1ram3 143 12 and and CC cord-029547-9ei1ram3 143 13 used use VBN cord-029547-9ei1ram3 143 14 on on IN cord-029547-9ei1ram3 143 15 a a DT cord-029547-9ei1ram3 143 16 small small JJ cord-029547-9ei1ram3 143 17 scale scale NN cord-029547-9ei1ram3 143 18 , , , cord-029547-9ei1ram3 143 19 58 58 CD cord-029547-9ei1ram3 143 20 its -PRON- PRP$ cord-029547-9ei1ram3 143 21 complex complex JJ cord-029547-9ei1ram3 143 22 operation operation NN cord-029547-9ei1ram3 143 23 and and CC cord-029547-9ei1ram3 143 24 time time NN cord-029547-9ei1ram3 143 25 - - HYPH cord-029547-9ei1ram3 143 26 consuming consume VBG cord-029547-9ei1ram3 143 27 process process NN cord-029547-9ei1ram3 143 28 make make VBP cord-029547-9ei1ram3 143 29 it -PRON- PRP cord-029547-9ei1ram3 143 30 difficult difficult JJ cord-029547-9ei1ram3 143 31 for for IN cord-029547-9ei1ram3 143 32 wider wide JJR cord-029547-9ei1ram3 143 33 clinical clinical JJ cord-029547-9ei1ram3 143 34 use use NN cord-029547-9ei1ram3 143 35 . . . cord-029547-9ei1ram3 144 1 SARS SARS NNP cord-029547-9ei1ram3 144 2 - - HYPH cord-029547-9ei1ram3 144 3 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 144 4 specific specific JJ cord-029547-9ei1ram3 144 5 antibody antibody NN cord-029547-9ei1ram3 144 6 detection detection NN cord-029547-9ei1ram3 144 7 is be VBZ cord-029547-9ei1ram3 144 8 a a DT cord-029547-9ei1ram3 144 9 simple simple JJ cord-029547-9ei1ram3 144 10 detection detection NN cord-029547-9ei1ram3 144 11 method method NN cord-029547-9ei1ram3 144 12 with with IN cord-029547-9ei1ram3 144 13 higher high JJR cord-029547-9ei1ram3 144 14 sensitivity sensitivity NN cord-029547-9ei1ram3 144 15 than than IN cord-029547-9ei1ram3 144 16 RT RT NNP cord-029547-9ei1ram3 144 17 - - HYPH cord-029547-9ei1ram3 144 18 PCR PCR NNP cord-029547-9ei1ram3 144 19 , , , cord-029547-9ei1ram3 144 20 59 59 CD cord-029547-9ei1ram3 144 21 but but CC cord-029547-9ei1ram3 144 22 its -PRON- PRP$ cord-029547-9ei1ram3 144 23 high high JJ cord-029547-9ei1ram3 144 24 sensitivity sensitivity NN cord-029547-9ei1ram3 144 25 is be VBZ cord-029547-9ei1ram3 144 26 only only RB cord-029547-9ei1ram3 144 27 reflected reflect VBN cord-029547-9ei1ram3 144 28 after after IN cord-029547-9ei1ram3 144 29 5.5 5.5 CD cord-029547-9ei1ram3 144 30 days day NNS cord-029547-9ei1ram3 144 31 of of IN cord-029547-9ei1ram3 144 32 symptom symptom NN cord-029547-9ei1ram3 144 33 onset onset NN cord-029547-9ei1ram3 144 34 , , , cord-029547-9ei1ram3 144 35 60 60 CD cord-029547-9ei1ram3 145 1 so so CC cord-029547-9ei1ram3 145 2 it -PRON- PRP cord-029547-9ei1ram3 145 3 is be VBZ cord-029547-9ei1ram3 145 4 just just RB cord-029547-9ei1ram3 145 5 a a DT cord-029547-9ei1ram3 145 6 supplementary supplementary JJ cord-029547-9ei1ram3 145 7 means mean NNS cord-029547-9ei1ram3 145 8 to to IN cord-029547-9ei1ram3 145 9 RT RT NNP cord-029547-9ei1ram3 145 10 - - HYPH cord-029547-9ei1ram3 145 11 PCR PCR NNP cord-029547-9ei1ram3 145 12 . . . cord-029547-9ei1ram3 146 1 Luckily luckily RB cord-029547-9ei1ram3 146 2 , , , cord-029547-9ei1ram3 146 3 the the DT cord-029547-9ei1ram3 146 4 fast fast JJ cord-029547-9ei1ram3 146 5 and and CC cord-029547-9ei1ram3 146 6 convenient convenient JJ cord-029547-9ei1ram3 146 7 method method NN cord-029547-9ei1ram3 146 8 , , , cord-029547-9ei1ram3 146 9 CT CT NNP cord-029547-9ei1ram3 146 10 , , , cord-029547-9ei1ram3 146 11 was be VBD cord-029547-9ei1ram3 146 12 found find VBN cord-029547-9ei1ram3 146 13 to to TO cord-029547-9ei1ram3 146 14 have have VB cord-029547-9ei1ram3 146 15 a a DT cord-029547-9ei1ram3 146 16 higher high JJR cord-029547-9ei1ram3 146 17 diagnostic diagnostic JJ cord-029547-9ei1ram3 146 18 sensitivity sensitivity NN cord-029547-9ei1ram3 146 19 for for IN cord-029547-9ei1ram3 146 20 COVID-19 covid-19 CD cord-029547-9ei1ram3 146 21 than than IN cord-029547-9ei1ram3 146 22 other other JJ cord-029547-9ei1ram3 146 23 diagnostic diagnostic JJ cord-029547-9ei1ram3 146 24 methods method NNS cord-029547-9ei1ram3 146 25 such such JJ cord-029547-9ei1ram3 146 26 as as IN cord-029547-9ei1ram3 146 27 RT RT NNP cord-029547-9ei1ram3 146 28 - - HYPH cord-029547-9ei1ram3 146 29 PCR PCR NNP cord-029547-9ei1ram3 146 30 and and CC cord-029547-9ei1ram3 146 31 can can MD cord-029547-9ei1ram3 146 32 predict predict VB cord-029547-9ei1ram3 146 33 the the DT cord-029547-9ei1ram3 146 34 prognosis prognosis NN cord-029547-9ei1ram3 146 35 of of IN cord-029547-9ei1ram3 146 36 patients patient NNS cord-029547-9ei1ram3 146 37 , , , cord-029547-9ei1ram3 146 38 57,61 57,61 CD cord-029547-9ei1ram3 146 39 thus thus RB cord-029547-9ei1ram3 146 40 it -PRON- PRP cord-029547-9ei1ram3 146 41 is be VBZ cord-029547-9ei1ram3 146 42 meaningful meaningful JJ cord-029547-9ei1ram3 146 43 for for IN cord-029547-9ei1ram3 146 44 the the DT cord-029547-9ei1ram3 146 45 initial initial JJ cord-029547-9ei1ram3 146 46 screening screening NN cord-029547-9ei1ram3 146 47 . . . cord-029547-9ei1ram3 147 1 Zhang Zhang NNP cord-029547-9ei1ram3 147 2 et et NNP cord-029547-9ei1ram3 147 3 al al NNP cord-029547-9ei1ram3 147 4 . . NNP cord-029547-9ei1ram3 147 5 developed develop VBD cord-029547-9ei1ram3 147 6 a a DT cord-029547-9ei1ram3 147 7 deep deep JJ cord-029547-9ei1ram3 147 8 learning learning NN cord-029547-9ei1ram3 147 9 system system NN cord-029547-9ei1ram3 147 10 for for IN cord-029547-9ei1ram3 147 11 image image NN cord-029547-9ei1ram3 147 12 recognition recognition NN cord-029547-9ei1ram3 147 13 of of IN cord-029547-9ei1ram3 147 14 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 147 15 patients patient NNS cord-029547-9ei1ram3 147 16 . . . cord-029547-9ei1ram3 148 1 They -PRON- PRP cord-029547-9ei1ram3 148 2 collected collect VBD cord-029547-9ei1ram3 148 3 CT CT NNP cord-029547-9ei1ram3 148 4 images image NNS cord-029547-9ei1ram3 148 5 from from IN cord-029547-9ei1ram3 148 6 4154 4154 CD cord-029547-9ei1ram3 148 7 patients patient NNS cord-029547-9ei1ram3 148 8 for for IN cord-029547-9ei1ram3 148 9 validation validation NN cord-029547-9ei1ram3 148 10 and and CC cord-029547-9ei1ram3 148 11 found find VBD cord-029547-9ei1ram3 148 12 this this DT cord-029547-9ei1ram3 148 13 system system NN cord-029547-9ei1ram3 148 14 precisely precisely RB cord-029547-9ei1ram3 148 15 identified identify VBD cord-029547-9ei1ram3 148 16 the the DT cord-029547-9ei1ram3 148 17 COVID-19 covid-19 JJ cord-029547-9ei1ram3 148 18 and and CC cord-029547-9ei1ram3 148 19 other other JJ cord-029547-9ei1ram3 148 20 forms form NNS cord-029547-9ei1ram3 148 21 of of IN cord-029547-9ei1ram3 148 22 pneumonia pneumonia NN cord-029547-9ei1ram3 148 23 , , , cord-029547-9ei1ram3 148 24 and and CC cord-029547-9ei1ram3 148 25 it -PRON- PRP cord-029547-9ei1ram3 148 26 also also RB cord-029547-9ei1ram3 148 27 divided divide VBD cord-029547-9ei1ram3 148 28 these these DT cord-029547-9ei1ram3 148 29 patients patient NNS cord-029547-9ei1ram3 148 30 into into IN cord-029547-9ei1ram3 148 31 high high JJ cord-029547-9ei1ram3 148 32 - - HYPH cord-029547-9ei1ram3 148 33 and and CC cord-029547-9ei1ram3 148 34 low low JJ cord-029547-9ei1ram3 148 35 - - HYPH cord-029547-9ei1ram3 148 36 risk risk NN cord-029547-9ei1ram3 148 37 groups group NNS cord-029547-9ei1ram3 148 38 correctly correctly RB cord-029547-9ei1ram3 148 39 , , , cord-029547-9ei1ram3 148 40 62 62 CD cord-029547-9ei1ram3 148 41 so so RB cord-029547-9ei1ram3 148 42 rational rational JJ cord-029547-9ei1ram3 148 43 use use NN cord-029547-9ei1ram3 148 44 of of IN cord-029547-9ei1ram3 148 45 artificial artificial JJ cord-029547-9ei1ram3 148 46 intelligence intelligence NN cord-029547-9ei1ram3 148 47 such such JJ cord-029547-9ei1ram3 148 48 as as IN cord-029547-9ei1ram3 148 49 this this DT cord-029547-9ei1ram3 148 50 may may MD cord-029547-9ei1ram3 148 51 be be VB cord-029547-9ei1ram3 148 52 better well RBR cord-029547-9ei1ram3 148 53 able able JJ cord-029547-9ei1ram3 148 54 to to TO cord-029547-9ei1ram3 148 55 screen screen VB cord-029547-9ei1ram3 148 56 COVID-19 covid-19 CD cord-029547-9ei1ram3 148 57 patients patient NNS cord-029547-9ei1ram3 148 58 and and CC cord-029547-9ei1ram3 148 59 give give VB cord-029547-9ei1ram3 148 60 them -PRON- PRP cord-029547-9ei1ram3 148 61 timely timely JJ cord-029547-9ei1ram3 148 62 interventions intervention NNS cord-029547-9ei1ram3 148 63 to to TO cord-029547-9ei1ram3 148 64 ensure ensure VB cord-029547-9ei1ram3 148 65 a a DT cord-029547-9ei1ram3 148 66 better well JJR cord-029547-9ei1ram3 148 67 prognosis prognosis NN cord-029547-9ei1ram3 148 68 . . . cord-029547-9ei1ram3 149 1 In in IN cord-029547-9ei1ram3 149 2 addition addition NN cord-029547-9ei1ram3 149 3 , , , cord-029547-9ei1ram3 149 4 a a DT cord-029547-9ei1ram3 149 5 CRISPR CRISPR NNP cord-029547-9ei1ram3 149 6 - - HYPH cord-029547-9ei1ram3 149 7 Cas12-based cas12-base VBN cord-029547-9ei1ram3 149 8 technique technique NN cord-029547-9ei1ram3 149 9 was be VBD cord-029547-9ei1ram3 149 10 confirmed confirm VBN cord-029547-9ei1ram3 149 11 to to TO cord-029547-9ei1ram3 149 12 be be VB cord-029547-9ei1ram3 149 13 a a DT cord-029547-9ei1ram3 149 14 faster fast JJR cord-029547-9ei1ram3 149 15 test test NN cord-029547-9ei1ram3 149 16 for for IN cord-029547-9ei1ram3 149 17 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 149 18 with with IN cord-029547-9ei1ram3 149 19 higher high JJR cord-029547-9ei1ram3 149 20 sensitivity sensitivity NN cord-029547-9ei1ram3 149 21 , , , cord-029547-9ei1ram3 149 22 63 63 CD cord-029547-9ei1ram3 149 23 thus thus RB cord-029547-9ei1ram3 149 24 it -PRON- PRP cord-029547-9ei1ram3 149 25 is be VBZ cord-029547-9ei1ram3 149 26 possibly possibly RB cord-029547-9ei1ram3 149 27 a a DT cord-029547-9ei1ram3 149 28 replacement replacement NN cord-029547-9ei1ram3 149 29 for for IN cord-029547-9ei1ram3 149 30 the the DT cord-029547-9ei1ram3 149 31 RT RT NNP cord-029547-9ei1ram3 149 32 - - HYPH cord-029547-9ei1ram3 149 33 PCR PCR NNP cord-029547-9ei1ram3 149 34 assay assay NN cord-029547-9ei1ram3 149 35 . . . cord-029547-9ei1ram3 150 1 The the DT cord-029547-9ei1ram3 150 2 therapeutic therapeutic JJ cord-029547-9ei1ram3 150 3 schedule schedule NN cord-029547-9ei1ram3 150 4 issued issue VBN cord-029547-9ei1ram3 150 5 by by IN cord-029547-9ei1ram3 150 6 the the DT cord-029547-9ei1ram3 150 7 General General NNP cord-029547-9ei1ram3 150 8 Office Office NNP cord-029547-9ei1ram3 150 9 of of IN cord-029547-9ei1ram3 150 10 National National NNP cord-029547-9ei1ram3 150 11 Health Health NNP cord-029547-9ei1ram3 150 12 Committee Committee NNP cord-029547-9ei1ram3 150 13 of of IN cord-029547-9ei1ram3 150 14 China China NNP cord-029547-9ei1ram3 150 15 on on IN cord-029547-9ei1ram3 150 16 3 3 CD cord-029547-9ei1ram3 150 17 March March NNP cord-029547-9ei1ram3 150 18 has have VBZ cord-029547-9ei1ram3 150 19 shown show VBN cord-029547-9ei1ram3 150 20 that that IN cord-029547-9ei1ram3 150 21 therapy therapy NN cord-029547-9ei1ram3 150 22 of of IN cord-029547-9ei1ram3 150 23 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 150 24 should should MD cord-029547-9ei1ram3 150 25 be be VB cord-029547-9ei1ram3 150 26 combined combine VBN cord-029547-9ei1ram3 150 27 with with IN cord-029547-9ei1ram3 150 28 etiological etiological JJ cord-029547-9ei1ram3 150 29 treatment treatment NN cord-029547-9ei1ram3 150 30 and and CC cord-029547-9ei1ram3 150 31 symptomatic symptomatic JJ cord-029547-9ei1ram3 150 32 treatment treatment NN cord-029547-9ei1ram3 150 33 , , , cord-029547-9ei1ram3 150 34 and and CC cord-029547-9ei1ram3 150 35 symptomatic symptomatic JJ cord-029547-9ei1ram3 150 36 treatment treatment NN cord-029547-9ei1ram3 150 37 is be VBZ cord-029547-9ei1ram3 150 38 especially especially RB cord-029547-9ei1ram3 150 39 important important JJ cord-029547-9ei1ram3 150 40 for for IN cord-029547-9ei1ram3 150 41 severe severe JJ cord-029547-9ei1ram3 150 42 and and CC cord-029547-9ei1ram3 150 43 critical critical JJ cord-029547-9ei1ram3 150 44 patients patient NNS cord-029547-9ei1ram3 150 45 . . . cord-029547-9ei1ram3 151 1 Furthermore furthermore RB cord-029547-9ei1ram3 151 2 , , , cord-029547-9ei1ram3 151 3 traditional traditional JJ cord-029547-9ei1ram3 151 4 Chinese chinese JJ cord-029547-9ei1ram3 151 5 medicine medicine NN cord-029547-9ei1ram3 151 6 can can MD cord-029547-9ei1ram3 151 7 be be VB cord-029547-9ei1ram3 151 8 also also RB cord-029547-9ei1ram3 151 9 used use VBN cord-029547-9ei1ram3 151 10 for for IN cord-029547-9ei1ram3 151 11 the the DT cord-029547-9ei1ram3 151 12 whole whole JJ cord-029547-9ei1ram3 151 13 treatment treatment NN cord-029547-9ei1ram3 151 14 cycle cycle NN cord-029547-9ei1ram3 151 15 of of IN cord-029547-9ei1ram3 151 16 COVID-19 covid-19 JJ cord-029547-9ei1ram3 151 17 patients patient NNS cord-029547-9ei1ram3 151 18 . . . cord-029547-9ei1ram3 152 1 55 55 CD cord-029547-9ei1ram3 153 1 In in IN cord-029547-9ei1ram3 153 2 the the DT cord-029547-9ei1ram3 153 3 processes process NNS cord-029547-9ei1ram3 153 4 of of IN cord-029547-9ei1ram3 153 5 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 153 6 therapy therapy NN cord-029547-9ei1ram3 153 7 , , , cord-029547-9ei1ram3 153 8 drugs drug NNS cord-029547-9ei1ram3 153 9 and and CC cord-029547-9ei1ram3 153 10 bioproducts bioproduct NNS cord-029547-9ei1ram3 153 11 play play VBP cord-029547-9ei1ram3 153 12 important important JJ cord-029547-9ei1ram3 153 13 roles role NNS cord-029547-9ei1ram3 153 14 ( ( -LRB- cord-029547-9ei1ram3 153 15 Table table NN cord-029547-9ei1ram3 153 16 3 3 CD cord-029547-9ei1ram3 153 17 ) ) -RRB- cord-029547-9ei1ram3 153 18 . . . cord-029547-9ei1ram3 154 1 Here here RB cord-029547-9ei1ram3 154 2 , , , cord-029547-9ei1ram3 154 3 we -PRON- PRP cord-029547-9ei1ram3 154 4 summarize summarize VBP cord-029547-9ei1ram3 154 5 the the DT cord-029547-9ei1ram3 154 6 main main JJ cord-029547-9ei1ram3 154 7 treatments treatment NNS cord-029547-9ei1ram3 154 8 of of IN cord-029547-9ei1ram3 154 9 novel novel JJ cord-029547-9ei1ram3 154 10 pneumonia pneumonia NN cord-029547-9ei1ram3 154 11 . . . cord-029547-9ei1ram3 155 1 The the DT cord-029547-9ei1ram3 155 2 etiological etiological JJ cord-029547-9ei1ram3 155 3 treatment treatment NN cord-029547-9ei1ram3 155 4 for for IN cord-029547-9ei1ram3 155 5 COVID-19 covid-19 JJ cord-029547-9ei1ram3 155 6 means mean VBZ cord-029547-9ei1ram3 155 7 antiviral antiviral JJ cord-029547-9ei1ram3 155 8 therapy therapy NN cord-029547-9ei1ram3 155 9 for for IN cord-029547-9ei1ram3 155 10 it -PRON- PRP cord-029547-9ei1ram3 155 11 , , , cord-029547-9ei1ram3 155 12 which which WDT cord-029547-9ei1ram3 155 13 depends depend VBZ cord-029547-9ei1ram3 155 14 on on IN cord-029547-9ei1ram3 155 15 antiviral antiviral JJ cord-029547-9ei1ram3 155 16 drugs drug NNS cord-029547-9ei1ram3 155 17 and and CC cord-029547-9ei1ram3 155 18 bioproducts bioproduct NNS cord-029547-9ei1ram3 155 19 . . . cord-029547-9ei1ram3 156 1 The the DT cord-029547-9ei1ram3 156 2 processes process NNS cord-029547-9ei1ram3 156 3 of of IN cord-029547-9ei1ram3 156 4 virus virus NN cord-029547-9ei1ram3 156 5 infection infection NN cord-029547-9ei1ram3 156 6 could could MD cord-029547-9ei1ram3 156 7 be be VB cord-029547-9ei1ram3 156 8 described describe VBN cord-029547-9ei1ram3 156 9 as as IN cord-029547-9ei1ram3 156 10 attachment attachment NN cord-029547-9ei1ram3 156 11 , , , cord-029547-9ei1ram3 156 12 penetration penetration NN cord-029547-9ei1ram3 156 13 , , , cord-029547-9ei1ram3 156 14 uncoating uncoating NN cord-029547-9ei1ram3 156 15 , , , cord-029547-9ei1ram3 156 16 biosynthesis biosynthesis NN cord-029547-9ei1ram3 156 17 , , , cord-029547-9ei1ram3 156 18 assembly assembly NN cord-029547-9ei1ram3 156 19 , , , cord-029547-9ei1ram3 156 20 and and CC cord-029547-9ei1ram3 156 21 release release NN cord-029547-9ei1ram3 156 22 . . . cord-029547-9ei1ram3 157 1 After after IN cord-029547-9ei1ram3 157 2 that that DT cord-029547-9ei1ram3 157 3 , , , cord-029547-9ei1ram3 157 4 the the DT cord-029547-9ei1ram3 157 5 virus virus NN cord-029547-9ei1ram3 157 6 complete complete VBP cord-029547-9ei1ram3 157 7 its -PRON- PRP$ cord-029547-9ei1ram3 157 8 proliferation proliferation NN cord-029547-9ei1ram3 157 9 and and CC cord-029547-9ei1ram3 157 10 causes cause VBZ cord-029547-9ei1ram3 157 11 damage damage NN cord-029547-9ei1ram3 157 12 to to IN cord-029547-9ei1ram3 157 13 host host NN cord-029547-9ei1ram3 157 14 cells cell NNS cord-029547-9ei1ram3 157 15 . . . cord-029547-9ei1ram3 158 1 Similarly similarly RB cord-029547-9ei1ram3 158 2 , , , cord-029547-9ei1ram3 158 3 the the DT cord-029547-9ei1ram3 158 4 mechanism mechanism NN cord-029547-9ei1ram3 158 5 of of IN cord-029547-9ei1ram3 158 6 antiviral antiviral JJ cord-029547-9ei1ram3 158 7 therapy therapy NN cord-029547-9ei1ram3 158 8 is be VBZ cord-029547-9ei1ram3 158 9 through through IN cord-029547-9ei1ram3 158 10 disturbing disturb VBG cord-029547-9ei1ram3 158 11 these these DT cord-029547-9ei1ram3 158 12 processes process NNS cord-029547-9ei1ram3 158 13 . . . cord-029547-9ei1ram3 159 1 Thus thus RB cord-029547-9ei1ram3 159 2 , , , cord-029547-9ei1ram3 159 3 the the DT cord-029547-9ei1ram3 159 4 medicines medicine NNS cord-029547-9ei1ram3 159 5 for for IN cord-029547-9ei1ram3 159 6 antiviral antiviral JJ cord-029547-9ei1ram3 159 7 treatment treatment NN cord-029547-9ei1ram3 159 8 of of IN cord-029547-9ei1ram3 159 9 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 159 10 are be VBP cord-029547-9ei1ram3 159 11 divided divide VBN cord-029547-9ei1ram3 159 12 into into IN cord-029547-9ei1ram3 159 13 penetration penetration NN cord-029547-9ei1ram3 159 14 and and CC cord-029547-9ei1ram3 159 15 uncoating uncoating NN cord-029547-9ei1ram3 159 16 inhibitors inhibitor NNS cord-029547-9ei1ram3 159 17 , , , cord-029547-9ei1ram3 159 18 biosynthesis biosynthesis NN cord-029547-9ei1ram3 159 19 inhibitors inhibitor NNS cord-029547-9ei1ram3 159 20 , , , cord-029547-9ei1ram3 159 21 and and CC cord-029547-9ei1ram3 159 22 assembly assembly NN cord-029547-9ei1ram3 159 23 inhibitors inhibitor NNS cord-029547-9ei1ram3 159 24 . . . cord-029547-9ei1ram3 160 1 Penetration penetration NN cord-029547-9ei1ram3 160 2 and and CC cord-029547-9ei1ram3 160 3 uncoating uncoating NN cord-029547-9ei1ram3 160 4 inhibitors inhibitor NNS cord-029547-9ei1ram3 160 5 of of IN cord-029547-9ei1ram3 160 6 SARS SARS NNP cord-029547-9ei1ram3 160 7 - - HYPH cord-029547-9ei1ram3 160 8 Cov-2 Cov-2 NNP cord-029547-9ei1ram3 160 9 mainly mainly RB cord-029547-9ei1ram3 160 10 include include VBP cord-029547-9ei1ram3 160 11 chloroquine chloroquine NN cord-029547-9ei1ram3 160 12 , , , cord-029547-9ei1ram3 160 13 arbidol arbidol NN cord-029547-9ei1ram3 160 14 , , , cord-029547-9ei1ram3 160 15 and and CC cord-029547-9ei1ram3 160 16 camostat camostat NNP cord-029547-9ei1ram3 160 17 mesilate mesilate NNP cord-029547-9ei1ram3 160 18 . . . cord-029547-9ei1ram3 161 1 Chloroquine Chloroquine NNP cord-029547-9ei1ram3 161 2 is be VBZ cord-029547-9ei1ram3 161 3 an an DT cord-029547-9ei1ram3 161 4 efficient efficient JJ cord-029547-9ei1ram3 161 5 drug drug NN cord-029547-9ei1ram3 161 6 for for IN cord-029547-9ei1ram3 161 7 treatment treatment NN cord-029547-9ei1ram3 161 8 of of IN cord-029547-9ei1ram3 161 9 malaria malaria NN cord-029547-9ei1ram3 161 10 as as RB cord-029547-9ei1ram3 161 11 well well RB cord-029547-9ei1ram3 161 12 as as IN cord-029547-9ei1ram3 161 13 autoimmune autoimmune JJ cord-029547-9ei1ram3 161 14 rheumatic rheumatic JJ cord-029547-9ei1ram3 161 15 diseases disease NNS cord-029547-9ei1ram3 161 16 . . . cord-029547-9ei1ram3 162 1 Wang Wang NNP cord-029547-9ei1ram3 162 2 and and CC cord-029547-9ei1ram3 162 3 colleagues colleague NNS cord-029547-9ei1ram3 162 4 treated treat VBD cord-029547-9ei1ram3 162 5 Vero Vero NNP cord-029547-9ei1ram3 162 6 E6 E6 NNP cord-029547-9ei1ram3 162 7 cells cell NNS cord-029547-9ei1ram3 162 8 that that WDT cord-029547-9ei1ram3 162 9 were be VBD cord-029547-9ei1ram3 162 10 infected infect VBN cord-029547-9ei1ram3 162 11 by by IN cord-029547-9ei1ram3 162 12 SARS SARS NNP cord-029547-9ei1ram3 162 13 - - HYPH cord-029547-9ei1ram3 162 14 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 162 15 with with IN cord-029547-9ei1ram3 162 16 several several JJ cord-029547-9ei1ram3 162 17 drugs drug NNS cord-029547-9ei1ram3 162 18 in in IN cord-029547-9ei1ram3 162 19 vitro vitro FW cord-029547-9ei1ram3 162 20 and and CC cord-029547-9ei1ram3 162 21 found find VBD cord-029547-9ei1ram3 162 22 a a DT cord-029547-9ei1ram3 162 23 low low JJ cord-029547-9ei1ram3 162 24 half half RB cord-029547-9ei1ram3 162 25 - - HYPH cord-029547-9ei1ram3 162 26 maximal maximal JJ cord-029547-9ei1ram3 162 27 effective effective JJ cord-029547-9ei1ram3 162 28 concentration concentration NN cord-029547-9ei1ram3 162 29 at at IN cord-029547-9ei1ram3 162 30 1.13 1.13 CD cord-029547-9ei1ram3 162 31 μmol μmol NNP cord-029547-9ei1ram3 162 32 and and CC cord-029547-9ei1ram3 162 33 a a DT cord-029547-9ei1ram3 162 34 high high JJ cord-029547-9ei1ram3 162 35 selectivity selectivity NN cord-029547-9ei1ram3 162 36 index index NN cord-029547-9ei1ram3 162 37 of of IN cord-029547-9ei1ram3 162 38 chloroquine chloroquine NN cord-029547-9ei1ram3 162 39 , , , cord-029547-9ei1ram3 162 40 indicating indicate VBG cord-029547-9ei1ram3 162 41 that that IN cord-029547-9ei1ram3 162 42 chloroquine chloroquine NN cord-029547-9ei1ram3 162 43 probably probably RB cord-029547-9ei1ram3 162 44 inhibits inhibit VBZ cord-029547-9ei1ram3 162 45 the the DT cord-029547-9ei1ram3 162 46 viral viral JJ cord-029547-9ei1ram3 162 47 infection infection NN cord-029547-9ei1ram3 162 48 . . . cord-029547-9ei1ram3 163 1 64 64 CD cord-029547-9ei1ram3 164 1 There there EX cord-029547-9ei1ram3 164 2 have have VBP cord-029547-9ei1ram3 164 3 been be VBN cord-029547-9ei1ram3 164 4 tens ten NNS cord-029547-9ei1ram3 164 5 of of IN cord-029547-9ei1ram3 164 6 clinical clinical JJ cord-029547-9ei1ram3 164 7 trials trial NNS cord-029547-9ei1ram3 164 8 to to TO cord-029547-9ei1ram3 164 9 confirm confirm VB cord-029547-9ei1ram3 164 10 the the DT cord-029547-9ei1ram3 164 11 safety safety NN cord-029547-9ei1ram3 164 12 and and CC cord-029547-9ei1ram3 164 13 efficiency efficiency NN cord-029547-9ei1ram3 164 14 of of IN cord-029547-9ei1ram3 164 15 chloroquine chloroquine NN cord-029547-9ei1ram3 164 16 in in IN cord-029547-9ei1ram3 164 17 treating treat VBG cord-029547-9ei1ram3 164 18 COVID-19 covid-19 CD cord-029547-9ei1ram3 164 19 patients patient NNS cord-029547-9ei1ram3 164 20 , , , cord-029547-9ei1ram3 164 21 and and CC cord-029547-9ei1ram3 164 22 its -PRON- PRP$ cord-029547-9ei1ram3 164 23 mechanism mechanism NN cord-029547-9ei1ram3 164 24 can can MD cord-029547-9ei1ram3 164 25 be be VB cord-029547-9ei1ram3 164 26 described describe VBN cord-029547-9ei1ram3 164 27 as as IN cord-029547-9ei1ram3 164 28 interfering interfere VBG cord-029547-9ei1ram3 164 29 with with IN cord-029547-9ei1ram3 164 30 the the DT cord-029547-9ei1ram3 164 31 glycosylation glycosylation NN cord-029547-9ei1ram3 164 32 of of IN cord-029547-9ei1ram3 164 33 ACE2 ACE2 NNP cord-029547-9ei1ram3 164 34 or or CC cord-029547-9ei1ram3 164 35 alkalizing alkalize VBG cord-029547-9ei1ram3 164 36 the the DT cord-029547-9ei1ram3 164 37 phagolysosome phagolysosome NN cord-029547-9ei1ram3 164 38 to to TO cord-029547-9ei1ram3 164 39 inhibit inhibit VB cord-029547-9ei1ram3 164 40 viral viral JJ cord-029547-9ei1ram3 164 41 replication replication NN cord-029547-9ei1ram3 164 42 , , , cord-029547-9ei1ram3 164 43 65 65 CD cord-029547-9ei1ram3 164 44 , , , cord-029547-9ei1ram3 164 45 66 66 CD cord-029547-9ei1ram3 164 46 which which WDT cord-029547-9ei1ram3 164 47 prevents prevent VBZ cord-029547-9ei1ram3 164 48 the the DT cord-029547-9ei1ram3 164 49 SARS SARS NNP cord-029547-9ei1ram3 164 50 - - HYPH cord-029547-9ei1ram3 164 51 Cov-2 Cov-2 NNP cord-029547-9ei1ram3 164 52 entering enter VBG cord-029547-9ei1ram3 164 53 the the DT cord-029547-9ei1ram3 164 54 host host NN cord-029547-9ei1ram3 164 55 cells cell NNS cord-029547-9ei1ram3 164 56 . . . cord-029547-9ei1ram3 165 1 The the DT cord-029547-9ei1ram3 165 2 in in IN cord-029547-9ei1ram3 165 3 vitro vitro FW cord-029547-9ei1ram3 165 4 study study NN cord-029547-9ei1ram3 165 5 indicated indicate VBD cord-029547-9ei1ram3 165 6 that that IN cord-029547-9ei1ram3 165 7 chloroquine chloroquine NN cord-029547-9ei1ram3 165 8 only only RB cord-029547-9ei1ram3 165 9 had have VBD cord-029547-9ei1ram3 165 10 an an DT cord-029547-9ei1ram3 165 11 antiviral antiviral JJ cord-029547-9ei1ram3 165 12 effect effect NN cord-029547-9ei1ram3 165 13 under under IN cord-029547-9ei1ram3 165 14 high high JJ cord-029547-9ei1ram3 165 15 doses dose NNS cord-029547-9ei1ram3 165 16 . . . cord-029547-9ei1ram3 166 1 However however RB cord-029547-9ei1ram3 166 2 , , , cord-029547-9ei1ram3 166 3 the the DT cord-029547-9ei1ram3 166 4 clinical clinical JJ cord-029547-9ei1ram3 166 5 data datum NNS cord-029547-9ei1ram3 166 6 of of IN cord-029547-9ei1ram3 166 7 chloroquine chloroquine NN cord-029547-9ei1ram3 166 8 showed show VBD cord-029547-9ei1ram3 166 9 the the DT cord-029547-9ei1ram3 166 10 mortality mortality NN cord-029547-9ei1ram3 166 11 of of IN cord-029547-9ei1ram3 166 12 highdosage highdosage NN cord-029547-9ei1ram3 166 13 group group NN cord-029547-9ei1ram3 166 14 was be VBD cord-029547-9ei1ram3 166 15 apparently apparently RB cord-029547-9ei1ram3 166 16 higher high JJR cord-029547-9ei1ram3 166 17 than than IN cord-029547-9ei1ram3 166 18 the the DT cord-029547-9ei1ram3 166 19 low low JJ cord-029547-9ei1ram3 166 20 - - HYPH cord-029547-9ei1ram3 166 21 dosage dosage NN cord-029547-9ei1ram3 166 22 group group NN cord-029547-9ei1ram3 166 23 , , , cord-029547-9ei1ram3 166 24 but but CC cord-029547-9ei1ram3 166 25 there there EX cord-029547-9ei1ram3 166 26 was be VBD cord-029547-9ei1ram3 166 27 no no DT cord-029547-9ei1ram3 166 28 significant significant JJ cord-029547-9ei1ram3 166 29 difference difference NN cord-029547-9ei1ram3 166 30 in in IN cord-029547-9ei1ram3 166 31 efficacy efficacy NN cord-029547-9ei1ram3 166 32 , , , cord-029547-9ei1ram3 166 33 67 67 CD cord-029547-9ei1ram3 166 34 and and CC cord-029547-9ei1ram3 166 35 the the DT cord-029547-9ei1ram3 166 36 QT QT NNP cord-029547-9ei1ram3 166 37 interval interval NN cord-029547-9ei1ram3 166 38 of of IN cord-029547-9ei1ram3 166 39 some some DT cord-029547-9ei1ram3 166 40 COVID-19 covid-19 JJ cord-029547-9ei1ram3 166 41 patients patient NNS cord-029547-9ei1ram3 166 42 was be VBD cord-029547-9ei1ram3 166 43 prolonged prolong VBN cord-029547-9ei1ram3 166 44 after after IN cord-029547-9ei1ram3 166 45 hydroxychloroquine hydroxychloroquine NN cord-029547-9ei1ram3 166 46 / / SYM cord-029547-9ei1ram3 166 47 azithromycin azithromycin NNP cord-029547-9ei1ram3 166 48 treatment treatment NN cord-029547-9ei1ram3 166 49 , , , cord-029547-9ei1ram3 166 50 68 68 CD cord-029547-9ei1ram3 167 1 thus thus RB cord-029547-9ei1ram3 167 2 it -PRON- PRP cord-029547-9ei1ram3 167 3 might may MD cord-029547-9ei1ram3 167 4 not not RB cord-029547-9ei1ram3 167 5 be be VB cord-029547-9ei1ram3 167 6 an an DT cord-029547-9ei1ram3 167 7 effective effective JJ cord-029547-9ei1ram3 167 8 medicine medicine NN cord-029547-9ei1ram3 167 9 for for IN cord-029547-9ei1ram3 167 10 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 167 11 . . . cord-029547-9ei1ram3 168 1 Arbidol Arbidol NNP cord-029547-9ei1ram3 168 2 is be VBZ cord-029547-9ei1ram3 168 3 the the DT cord-029547-9ei1ram3 168 4 other other JJ cord-029547-9ei1ram3 168 5 penetration penetration NN cord-029547-9ei1ram3 168 6 inhibitor inhibitor NN cord-029547-9ei1ram3 168 7 that that WDT cord-029547-9ei1ram3 168 8 suppresses suppress VBZ cord-029547-9ei1ram3 168 9 the the DT cord-029547-9ei1ram3 168 10 fusion fusion NN cord-029547-9ei1ram3 168 11 of of IN cord-029547-9ei1ram3 168 12 the the DT cord-029547-9ei1ram3 168 13 virus virus NN cord-029547-9ei1ram3 168 14 lipid lipid NN cord-029547-9ei1ram3 168 15 membrane membrane NN cord-029547-9ei1ram3 168 16 and and CC cord-029547-9ei1ram3 168 17 host host NN cord-029547-9ei1ram3 168 18 cells cell NNS cord-029547-9ei1ram3 168 19 to to TO cord-029547-9ei1ram3 168 20 block block VB cord-029547-9ei1ram3 168 21 the the DT cord-029547-9ei1ram3 168 22 replication replication NN cord-029547-9ei1ram3 168 23 of of IN cord-029547-9ei1ram3 168 24 the the DT cord-029547-9ei1ram3 168 25 virus virus NN cord-029547-9ei1ram3 168 26 . . . cord-029547-9ei1ram3 169 1 Arbidol Arbidol NNP cord-029547-9ei1ram3 169 2 also also RB cord-029547-9ei1ram3 169 3 has have VBZ cord-029547-9ei1ram3 169 4 the the DT cord-029547-9ei1ram3 169 5 function function NN cord-029547-9ei1ram3 169 6 of of IN cord-029547-9ei1ram3 169 7 interferon interferon NN cord-029547-9ei1ram3 169 8 ( ( -LRB- cord-029547-9ei1ram3 169 9 IFN IFN NNP cord-029547-9ei1ram3 169 10 ) ) -RRB- cord-029547-9ei1ram3 169 11 inducement inducement NN cord-029547-9ei1ram3 169 12 , , , cord-029547-9ei1ram3 169 13 thus thus RB cord-029547-9ei1ram3 169 14 it -PRON- PRP cord-029547-9ei1ram3 169 15 has have VBZ cord-029547-9ei1ram3 169 16 been be VBN cord-029547-9ei1ram3 169 17 widely widely RB cord-029547-9ei1ram3 169 18 used use VBN cord-029547-9ei1ram3 169 19 to to TO cord-029547-9ei1ram3 169 20 treat treat VB cord-029547-9ei1ram3 169 21 A a NN cord-029547-9ei1ram3 169 22 and and CC cord-029547-9ei1ram3 169 23 B b NN cord-029547-9ei1ram3 169 24 influenza influenza NN cord-029547-9ei1ram3 169 25 viruses virus NNS cord-029547-9ei1ram3 169 26 . . . cord-029547-9ei1ram3 170 1 It -PRON- PRP cord-029547-9ei1ram3 170 2 is be VBZ cord-029547-9ei1ram3 170 3 promising promising JJ cord-029547-9ei1ram3 170 4 that that IN cord-029547-9ei1ram3 170 5 several several JJ cord-029547-9ei1ram3 170 6 studies study NNS cord-029547-9ei1ram3 170 7 of of IN cord-029547-9ei1ram3 170 8 arbidol arbidol NNP cord-029547-9ei1ram3 170 9 have have VBP cord-029547-9ei1ram3 170 10 shown show VBN cord-029547-9ei1ram3 170 11 a a DT cord-029547-9ei1ram3 170 12 significant significant JJ cord-029547-9ei1ram3 170 13 therapeutic therapeutic JJ cord-029547-9ei1ram3 170 14 effect effect NN cord-029547-9ei1ram3 170 15 for for IN cord-029547-9ei1ram3 170 16 curing cure VBG cord-029547-9ei1ram3 170 17 COVID-19 COVID-19 JJR cord-029547-9ei1ram3 170 18 patients patient NNS cord-029547-9ei1ram3 170 19 . . . cord-029547-9ei1ram3 171 1 Wang Wang NNP cord-029547-9ei1ram3 171 2 and and CC cord-029547-9ei1ram3 171 3 colleagues colleague NNS cord-029547-9ei1ram3 171 4 found find VBD cord-029547-9ei1ram3 171 5 arbidol arbidol NN cord-029547-9ei1ram3 171 6 reduced reduce VBD cord-029547-9ei1ram3 171 7 the the DT cord-029547-9ei1ram3 171 8 mortality mortality NN cord-029547-9ei1ram3 171 9 and and CC cord-029547-9ei1ram3 171 10 improved improve VBN cord-029547-9ei1ram3 171 11 discharging discharge VBG cord-029547-9ei1ram3 171 12 rate rate NN cord-029547-9ei1ram3 171 13 by by IN cord-029547-9ei1ram3 171 14 analysis analysis NN cord-029547-9ei1ram3 171 15 of of IN cord-029547-9ei1ram3 171 16 67 67 CD cord-029547-9ei1ram3 171 17 discharged discharge VBN cord-029547-9ei1ram3 171 18 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 171 19 patients patient NNS cord-029547-9ei1ram3 171 20 . . . cord-029547-9ei1ram3 172 1 69 69 CD cord-029547-9ei1ram3 173 1 Furthermore furthermore RB cord-029547-9ei1ram3 173 2 , , , cord-029547-9ei1ram3 173 3 the the DT cord-029547-9ei1ram3 173 4 other other JJ cord-029547-9ei1ram3 173 5 study study NN cord-029547-9ei1ram3 173 6 compared compare VBD cord-029547-9ei1ram3 173 7 the the DT cord-029547-9ei1ram3 173 8 treatment treatment NN cord-029547-9ei1ram3 173 9 effects effect NNS cord-029547-9ei1ram3 173 10 between between IN cord-029547-9ei1ram3 173 11 combination combination NN cord-029547-9ei1ram3 173 12 of of IN cord-029547-9ei1ram3 173 13 arbidol arbidol NN cord-029547-9ei1ram3 173 14 and and CC cord-029547-9ei1ram3 173 15 lopinavir lopinavir NNP cord-029547-9ei1ram3 173 16 / / SYM cord-029547-9ei1ram3 173 17 ritonavir ritonavir NNS cord-029547-9ei1ram3 173 18 , , , cord-029547-9ei1ram3 173 19 and and CC cord-029547-9ei1ram3 173 20 simple simple JJ cord-029547-9ei1ram3 173 21 lopinavir lopinavir NNS cord-029547-9ei1ram3 173 22 / / SYM cord-029547-9ei1ram3 173 23 ritonavir ritonavir NNS cord-029547-9ei1ram3 173 24 , , , cord-029547-9ei1ram3 173 25 finding find VBG cord-029547-9ei1ram3 173 26 that that IN cord-029547-9ei1ram3 173 27 their -PRON- PRP$ cord-029547-9ei1ram3 173 28 CT CT NNP cord-029547-9ei1ram3 173 29 scan scan JJ cord-029547-9ei1ram3 173 30 improvement improvement NN cord-029547-9ei1ram3 173 31 rates rate NNS cord-029547-9ei1ram3 173 32 are be VBP cord-029547-9ei1ram3 173 33 69 69 CD cord-029547-9ei1ram3 173 34 % % NN cord-029547-9ei1ram3 173 35 and and CC cord-029547-9ei1ram3 173 36 29 29 CD cord-029547-9ei1ram3 173 37 % % NN cord-029547-9ei1ram3 173 38 , , , cord-029547-9ei1ram3 173 39 and and CC cord-029547-9ei1ram3 173 40 viral viral JJ cord-029547-9ei1ram3 173 41 RNA RNA NNP cord-029547-9ei1ram3 173 42 decrement decrement NN cord-029547-9ei1ram3 173 43 rates rate NNS cord-029547-9ei1ram3 173 44 are be VBP cord-029547-9ei1ram3 173 45 75 75 CD cord-029547-9ei1ram3 173 46 % % NN cord-029547-9ei1ram3 173 47 and and CC cord-029547-9ei1ram3 173 48 35 35 CD cord-029547-9ei1ram3 173 49 % % NN cord-029547-9ei1ram3 173 50 , , , cord-029547-9ei1ram3 173 51 respectively respectively RB cord-029547-9ei1ram3 173 52 . . . cord-029547-9ei1ram3 174 1 70 70 CD cord-029547-9ei1ram3 175 1 Thus thus RB cord-029547-9ei1ram3 175 2 , , , cord-029547-9ei1ram3 175 3 arbidol arbidol NN cord-029547-9ei1ram3 175 4 perhaps perhaps RB cord-029547-9ei1ram3 175 5 serves serve VBZ cord-029547-9ei1ram3 175 6 as as IN cord-029547-9ei1ram3 175 7 a a DT cord-029547-9ei1ram3 175 8 specific specific JJ cord-029547-9ei1ram3 175 9 treatment treatment NN cord-029547-9ei1ram3 175 10 for for IN cord-029547-9ei1ram3 175 11 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 175 12 . . . cord-029547-9ei1ram3 176 1 However however RB cord-029547-9ei1ram3 176 2 , , , cord-029547-9ei1ram3 176 3 another another DT cord-029547-9ei1ram3 176 4 clinical clinical JJ cord-029547-9ei1ram3 176 5 report report NN cord-029547-9ei1ram3 176 6 pointed point VBD cord-029547-9ei1ram3 176 7 out out RP cord-029547-9ei1ram3 176 8 arbidol arbidol NN cord-029547-9ei1ram3 176 9 could could MD cord-029547-9ei1ram3 176 10 not not RB cord-029547-9ei1ram3 176 11 improve improve VB cord-029547-9ei1ram3 176 12 the the DT cord-029547-9ei1ram3 176 13 symptoms symptom NNS cord-029547-9ei1ram3 176 14 or or CC cord-029547-9ei1ram3 176 15 accelerate accelerate VB cord-029547-9ei1ram3 176 16 the the DT cord-029547-9ei1ram3 176 17 clearance clearance NN cord-029547-9ei1ram3 176 18 of of IN cord-029547-9ei1ram3 176 19 SARS SARS NNP cord-029547-9ei1ram3 176 20 - - HYPH cord-029547-9ei1ram3 176 21 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 176 22 . . . cord-029547-9ei1ram3 177 1 71 71 CD cord-029547-9ei1ram3 178 1 Thus thus RB cord-029547-9ei1ram3 178 2 , , , cord-029547-9ei1ram3 178 3 further further JJ cord-029547-9ei1ram3 178 4 studies study NNS cord-029547-9ei1ram3 178 5 are be VBP cord-029547-9ei1ram3 178 6 needed need VBN cord-029547-9ei1ram3 178 7 to to TO cord-029547-9ei1ram3 178 8 validate validate VB cord-029547-9ei1ram3 178 9 its -PRON- PRP$ cord-029547-9ei1ram3 178 10 antiviral antiviral JJ cord-029547-9ei1ram3 178 11 efficiency efficiency NN cord-029547-9ei1ram3 178 12 . . . cord-029547-9ei1ram3 179 1 Camostat Camostat NNP cord-029547-9ei1ram3 179 2 mesylate mesylate NNP cord-029547-9ei1ram3 179 3 is be VBZ cord-029547-9ei1ram3 179 4 a a DT cord-029547-9ei1ram3 179 5 specific specific JJ cord-029547-9ei1ram3 179 6 drug drug NN cord-029547-9ei1ram3 179 7 for for IN cord-029547-9ei1ram3 179 8 inhibiting inhibit VBG cord-029547-9ei1ram3 179 9 TMPRSS2 TMPRSS2 NNP cord-029547-9ei1ram3 179 10 , , , cord-029547-9ei1ram3 179 11 a a DT cord-029547-9ei1ram3 179 12 protease protease NN cord-029547-9ei1ram3 179 13 used use VBN cord-029547-9ei1ram3 179 14 for for IN cord-029547-9ei1ram3 179 15 S s NN cord-029547-9ei1ram3 179 16 protein protein NN cord-029547-9ei1ram3 179 17 priming prime VBG cord-029547-9ei1ram3 179 18 to to TO cord-029547-9ei1ram3 179 19 promote promote VB cord-029547-9ei1ram3 179 20 the the DT cord-029547-9ei1ram3 179 21 entry entry NN cord-029547-9ei1ram3 179 22 of of IN cord-029547-9ei1ram3 179 23 SARS SARS NNP cord-029547-9ei1ram3 179 24 - - HYPH cord-029547-9ei1ram3 179 25 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 179 26 , , , cord-029547-9ei1ram3 179 27 thus thus RB cord-029547-9ei1ram3 179 28 it -PRON- PRP cord-029547-9ei1ram3 179 29 is be VBZ cord-029547-9ei1ram3 179 30 another another DT cord-029547-9ei1ram3 179 31 potential potential JJ cord-029547-9ei1ram3 179 32 penetration penetration NN cord-029547-9ei1ram3 179 33 inhibitor inhibitor NN cord-029547-9ei1ram3 179 34 . . . cord-029547-9ei1ram3 180 1 23 23 CD cord-029547-9ei1ram3 181 1 However however RB cord-029547-9ei1ram3 181 2 , , , cord-029547-9ei1ram3 181 3 there there EX cord-029547-9ei1ram3 181 4 is be VBZ cord-029547-9ei1ram3 181 5 still still RB cord-029547-9ei1ram3 181 6 lack lack NN cord-029547-9ei1ram3 181 7 of of IN cord-029547-9ei1ram3 181 8 clinical clinical JJ cord-029547-9ei1ram3 181 9 evidence evidence NN cord-029547-9ei1ram3 181 10 to to TO cord-029547-9ei1ram3 181 11 prove prove VB cord-029547-9ei1ram3 181 12 its -PRON- PRP$ cord-029547-9ei1ram3 181 13 effectiveness effectiveness NN cord-029547-9ei1ram3 181 14 . . . cord-029547-9ei1ram3 182 1 The the DT cord-029547-9ei1ram3 182 2 biosynthesis biosynthesis NN cord-029547-9ei1ram3 182 3 inhibitors inhibitor NNS cord-029547-9ei1ram3 182 4 for for IN cord-029547-9ei1ram3 182 5 SARS SARS NNP cord-029547-9ei1ram3 182 6 - - HYPH cord-029547-9ei1ram3 182 7 Cov-2 Cov-2 NNP cord-029547-9ei1ram3 182 8 chiefly chiefly RB cord-029547-9ei1ram3 182 9 contain contain VBP cord-029547-9ei1ram3 182 10 remdesivir remdesivir NNP cord-029547-9ei1ram3 182 11 , , , cord-029547-9ei1ram3 182 12 sofosbuvir sofosbuvir NNP cord-029547-9ei1ram3 182 13 , , , cord-029547-9ei1ram3 182 14 ribavirin ribavirin NN cord-029547-9ei1ram3 182 15 , , , cord-029547-9ei1ram3 182 16 and and CC cord-029547-9ei1ram3 182 17 lopinavir lopinavir NNP cord-029547-9ei1ram3 182 18 / / SYM cord-029547-9ei1ram3 182 19 ritonavir ritonavir NNS cord-029547-9ei1ram3 182 20 . . . cord-029547-9ei1ram3 183 1 Remdesivir Remdesivir NNP cord-029547-9ei1ram3 183 2 is be VBZ cord-029547-9ei1ram3 183 3 as as RB cord-029547-9ei1ram3 183 4 kind kind RB cord-029547-9ei1ram3 183 5 of of RB cord-029547-9ei1ram3 183 6 broad broad JJ cord-029547-9ei1ram3 183 7 spectrum spectrum JJ cord-029547-9ei1ram3 183 8 antiviral antiviral JJ cord-029547-9ei1ram3 183 9 medicine medicine NN cord-029547-9ei1ram3 183 10 that that WDT cord-029547-9ei1ram3 183 11 suppresses suppress VBZ cord-029547-9ei1ram3 183 12 the the DT cord-029547-9ei1ram3 183 13 virus virus NN cord-029547-9ei1ram3 183 14 replication replication NN cord-029547-9ei1ram3 183 15 through through IN cord-029547-9ei1ram3 183 16 inhibiting inhibit VBG cord-029547-9ei1ram3 183 17 the the DT cord-029547-9ei1ram3 183 18 activity activity NN cord-029547-9ei1ram3 183 19 of of IN cord-029547-9ei1ram3 183 20 RNAdependent RNAdependent NNP cord-029547-9ei1ram3 183 21 RNA RNA NNP cord-029547-9ei1ram3 183 22 polymerase polymerase NN cord-029547-9ei1ram3 183 23 , , , cord-029547-9ei1ram3 183 24 72 72 CD cord-029547-9ei1ram3 183 25 , , , cord-029547-9ei1ram3 183 26 73 73 CD cord-029547-9ei1ram3 183 27 and and CC cord-029547-9ei1ram3 183 28 its -PRON- PRP$ cord-029547-9ei1ram3 183 29 efficiency efficiency NN cord-029547-9ei1ram3 183 30 has have VBZ cord-029547-9ei1ram3 183 31 been be VBN cord-029547-9ei1ram3 183 32 widely widely RB cord-029547-9ei1ram3 183 33 confirmed confirm VBN cord-029547-9ei1ram3 183 34 in in IN cord-029547-9ei1ram3 183 35 coronaviruses coronaviruse NNS cord-029547-9ei1ram3 183 36 such such JJ cord-029547-9ei1ram3 183 37 as as IN cord-029547-9ei1ram3 183 38 SARS SARS NNP cord-029547-9ei1ram3 183 39 - - HYPH cord-029547-9ei1ram3 183 40 CoV CoV NNP cord-029547-9ei1ram3 183 41 and and CC cord-029547-9ei1ram3 183 42 MERS MERS NNP cord-029547-9ei1ram3 184 1 -CoV. -cov. ADD cord-029547-9ei1ram3 185 1 Recently recently RB cord-029547-9ei1ram3 185 2 , , , cord-029547-9ei1ram3 185 3 remdesivir remdesivir NNP cord-029547-9ei1ram3 185 4 has have VBZ cord-029547-9ei1ram3 185 5 been be VBN cord-029547-9ei1ram3 185 6 found find VBN cord-029547-9ei1ram3 185 7 to to TO cord-029547-9ei1ram3 185 8 be be VB cord-029547-9ei1ram3 185 9 a a DT cord-029547-9ei1ram3 185 10 potential potential JJ cord-029547-9ei1ram3 185 11 drug drug NN cord-029547-9ei1ram3 185 12 to to TO cord-029547-9ei1ram3 185 13 treat treat VB cord-029547-9ei1ram3 185 14 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 185 15 . . . cord-029547-9ei1ram3 186 1 A a DT cord-029547-9ei1ram3 186 2 previous previous JJ cord-029547-9ei1ram3 186 3 study study NN cord-029547-9ei1ram3 186 4 showed show VBD cord-029547-9ei1ram3 186 5 that that IN cord-029547-9ei1ram3 186 6 half half RB cord-029547-9ei1ram3 186 7 - - HYPH cord-029547-9ei1ram3 186 8 maximal maximal JJ cord-029547-9ei1ram3 186 9 effective effective JJ cord-029547-9ei1ram3 186 10 concentration concentration NN cord-029547-9ei1ram3 186 11 of of IN cord-029547-9ei1ram3 186 12 remdesivir remdesivir NNP cord-029547-9ei1ram3 186 13 was be VBD cord-029547-9ei1ram3 186 14 0.77 0.77 CD cord-029547-9ei1ram3 186 15 in in IN cord-029547-9ei1ram3 186 16 an an DT cord-029547-9ei1ram3 186 17 in in FW cord-029547-9ei1ram3 186 18 vitro vitro FW cord-029547-9ei1ram3 186 19 test test NN cord-029547-9ei1ram3 186 20 treating treat VBG cord-029547-9ei1ram3 186 21 COVID-19 COVID-19 VBD cord-029547-9ei1ram3 186 22 with with IN cord-029547-9ei1ram3 186 23 a a DT cord-029547-9ei1ram3 186 24 high high JJ cord-029547-9ei1ram3 186 25 selectivity selectivity NN cord-029547-9ei1ram3 186 26 index index NN cord-029547-9ei1ram3 186 27 , , , cord-029547-9ei1ram3 186 28 demonstrating demonstrate VBG cord-029547-9ei1ram3 186 29 its -PRON- PRP$ cord-029547-9ei1ram3 186 30 therapeutic therapeutic JJ cord-029547-9ei1ram3 186 31 effect effect NN cord-029547-9ei1ram3 186 32 . . . cord-029547-9ei1ram3 187 1 64 64 CD cord-029547-9ei1ram3 188 1 There there RB cord-029547-9ei1ram3 188 2 , , , cord-029547-9ei1ram3 188 3 the the DT cord-029547-9ei1ram3 188 4 first first JJ cord-029547-9ei1ram3 188 5 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 188 6 case case NN cord-029547-9ei1ram3 188 7 of of IN cord-029547-9ei1ram3 188 8 America America NNP cord-029547-9ei1ram3 188 9 was be VBD cord-029547-9ei1ram3 188 10 reported report VBN cord-029547-9ei1ram3 188 11 to to TO cord-029547-9ei1ram3 188 12 be be VB cord-029547-9ei1ram3 188 13 cured cure VBN cord-029547-9ei1ram3 188 14 completely completely RB cord-029547-9ei1ram3 188 15 after after IN cord-029547-9ei1ram3 188 16 intravenous intravenous JJ cord-029547-9ei1ram3 188 17 injection injection NN cord-029547-9ei1ram3 188 18 of of IN cord-029547-9ei1ram3 188 19 remdesivir remdesivir NNP cord-029547-9ei1ram3 188 20 , , , cord-029547-9ei1ram3 188 21 74 74 CD cord-029547-9ei1ram3 188 22 and and CC cord-029547-9ei1ram3 188 23 clinical clinical JJ cord-029547-9ei1ram3 188 24 data datum NNS cord-029547-9ei1ram3 188 25 showed show VBD cord-029547-9ei1ram3 188 26 that that IN cord-029547-9ei1ram3 188 27 remdesivir remdesivir NNP cord-029547-9ei1ram3 188 28 dramatically dramatically RB cord-029547-9ei1ram3 188 29 alleviated alleviate VBD cord-029547-9ei1ram3 188 30 clinical clinical JJ cord-029547-9ei1ram3 188 31 symptoms symptom NNS cord-029547-9ei1ram3 188 32 and and CC cord-029547-9ei1ram3 188 33 reduced reduce VBN cord-029547-9ei1ram3 188 34 mortality mortality NN cord-029547-9ei1ram3 188 35 for for IN cord-029547-9ei1ram3 188 36 severe severe JJ cord-029547-9ei1ram3 188 37 patients patient NNS cord-029547-9ei1ram3 188 38 , , , cord-029547-9ei1ram3 188 39 75 75 CD cord-029547-9ei1ram3 188 40 which which WDT cord-029547-9ei1ram3 188 41 demonstrated demonstrate VBD cord-029547-9ei1ram3 188 42 it -PRON- PRP cord-029547-9ei1ram3 188 43 is be VBZ cord-029547-9ei1ram3 188 44 a a DT cord-029547-9ei1ram3 188 45 potential potential JJ cord-029547-9ei1ram3 188 46 drug drug NN cord-029547-9ei1ram3 188 47 for for IN cord-029547-9ei1ram3 188 48 treating treat VBG cord-029547-9ei1ram3 188 49 novel novel JJ cord-029547-9ei1ram3 188 50 pneumonia pneumonia NN cord-029547-9ei1ram3 188 51 . . . cord-029547-9ei1ram3 189 1 However however RB cord-029547-9ei1ram3 189 2 , , , cord-029547-9ei1ram3 189 3 a a DT cord-029547-9ei1ram3 189 4 patient patient NN cord-029547-9ei1ram3 189 5 died die VBD cord-029547-9ei1ram3 189 6 of of IN cord-029547-9ei1ram3 189 7 hypotension hypotension NN cord-029547-9ei1ram3 189 8 and and CC cord-029547-9ei1ram3 189 9 cardiac cardiac JJ cord-029547-9ei1ram3 189 10 arrest arrest NN cord-029547-9ei1ram3 189 11 after after IN cord-029547-9ei1ram3 189 12 remdesivir remdesivir NNP cord-029547-9ei1ram3 189 13 treatment treatment NN cord-029547-9ei1ram3 189 14 in in IN cord-029547-9ei1ram3 189 15 a a DT cord-029547-9ei1ram3 189 16 randomized randomized JJ cord-029547-9ei1ram3 189 17 controlled control VBN cord-029547-9ei1ram3 189 18 trial trial NN cord-029547-9ei1ram3 189 19 of of IN cord-029547-9ei1ram3 189 20 Ebola Ebola NNP cord-029547-9ei1ram3 189 21 virus virus NN cord-029547-9ei1ram3 189 22 ( ( -LRB- cord-029547-9ei1ram3 189 23 EBOV EBOV NNP cord-029547-9ei1ram3 189 24 ) ) -RRB- cord-029547-9ei1ram3 189 25 treatment treatment NN cord-029547-9ei1ram3 189 26 , , , cord-029547-9ei1ram3 189 27 76 76 CD cord-029547-9ei1ram3 189 28 and and CC cord-029547-9ei1ram3 189 29 60 60 CD cord-029547-9ei1ram3 189 30 % % NN cord-029547-9ei1ram3 189 31 COVID-19 covid-19 CD cord-029547-9ei1ram3 189 32 patients patient NNS cord-029547-9ei1ram3 189 33 had have VBD cord-029547-9ei1ram3 189 34 side side NN cord-029547-9ei1ram3 189 35 effects effect NNS cord-029547-9ei1ram3 189 36 after after IN cord-029547-9ei1ram3 189 37 using use VBG cord-029547-9ei1ram3 189 38 remdesivir remdesivir NNP cord-029547-9ei1ram3 189 39 , , , cord-029547-9ei1ram3 189 40 75 75 CD cord-029547-9ei1ram3 189 41 which which WDT cord-029547-9ei1ram3 189 42 indicated indicate VBD cord-029547-9ei1ram3 189 43 its -PRON- PRP$ cord-029547-9ei1ram3 189 44 security security NN cord-029547-9ei1ram3 189 45 is be VBZ cord-029547-9ei1ram3 189 46 worthy worthy JJ cord-029547-9ei1ram3 189 47 of of IN cord-029547-9ei1ram3 189 48 further further JJ cord-029547-9ei1ram3 189 49 confirmation confirmation NN cord-029547-9ei1ram3 189 50 . . . cord-029547-9ei1ram3 190 1 Up up IN cord-029547-9ei1ram3 190 2 to to IN cord-029547-9ei1ram3 190 3 now now RB cord-029547-9ei1ram3 190 4 , , , cord-029547-9ei1ram3 190 5 several several JJ cord-029547-9ei1ram3 190 6 agencies agency NNS cord-029547-9ei1ram3 190 7 have have VBP cord-029547-9ei1ram3 190 8 published publish VBN cord-029547-9ei1ram3 190 9 conflicting conflict VBG cord-029547-9ei1ram3 190 10 clinical clinical JJ cord-029547-9ei1ram3 190 11 results result NNS cord-029547-9ei1ram3 190 12 from from IN cord-029547-9ei1ram3 190 13 remdesivir remdesivir NNP cord-029547-9ei1ram3 190 14 . . . cord-029547-9ei1ram3 191 1 77 77 CD cord-029547-9ei1ram3 191 2 , , , cord-029547-9ei1ram3 191 3 78 78 CD cord-029547-9ei1ram3 192 1 Thus thus RB cord-029547-9ei1ram3 192 2 , , , cord-029547-9ei1ram3 192 3 more more JJR cord-029547-9ei1ram3 192 4 research research NN cord-029547-9ei1ram3 192 5 should should MD cord-029547-9ei1ram3 192 6 be be VB cord-029547-9ei1ram3 192 7 conducted conduct VBN cord-029547-9ei1ram3 192 8 to to TO cord-029547-9ei1ram3 192 9 verify verify VB cord-029547-9ei1ram3 192 10 its -PRON- PRP$ cord-029547-9ei1ram3 192 11 curative curative JJ cord-029547-9ei1ram3 192 12 efficacy efficacy NN cord-029547-9ei1ram3 192 13 . . . cord-029547-9ei1ram3 193 1 Furthermore furthermore RB cord-029547-9ei1ram3 193 2 , , , cord-029547-9ei1ram3 193 3 in in IN cord-029547-9ei1ram3 193 4 vitro vitro FW cord-029547-9ei1ram3 193 5 tests test NNS cord-029547-9ei1ram3 193 6 showed show VBD cord-029547-9ei1ram3 193 7 that that IN cord-029547-9ei1ram3 193 8 other other JJ cord-029547-9ei1ram3 193 9 broad broad JJ cord-029547-9ei1ram3 193 10 - - HYPH cord-029547-9ei1ram3 193 11 spectrum spectrum NN cord-029547-9ei1ram3 193 12 antiviral antiviral JJ cord-029547-9ei1ram3 193 13 medicines medicine NNS cord-029547-9ei1ram3 193 14 such such JJ cord-029547-9ei1ram3 193 15 as as IN cord-029547-9ei1ram3 193 16 sofosbuvir sofosbuvir NNP cord-029547-9ei1ram3 193 17 and and CC cord-029547-9ei1ram3 193 18 ribavirin ribavirin NN cord-029547-9ei1ram3 193 19 interacted interact VBD cord-029547-9ei1ram3 193 20 with with IN cord-029547-9ei1ram3 193 21 RNA RNA NNP cord-029547-9ei1ram3 193 22 - - HYPH cord-029547-9ei1ram3 193 23 dependent dependent JJ cord-029547-9ei1ram3 193 24 RNA RNA NNP cord-029547-9ei1ram3 193 25 polymerase polymerase NN cord-029547-9ei1ram3 193 26 of of IN cord-029547-9ei1ram3 193 27 SARS SARS NNP cord-029547-9ei1ram3 193 28 - - HYPH cord-029547-9ei1ram3 193 29 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 193 30 , , , cord-029547-9ei1ram3 193 31 which which WDT cord-029547-9ei1ram3 193 32 prevents prevent VBZ cord-029547-9ei1ram3 193 33 the the DT cord-029547-9ei1ram3 193 34 replication replication NN cord-029547-9ei1ram3 193 35 of of IN cord-029547-9ei1ram3 193 36 virus virus NN cord-029547-9ei1ram3 193 37 , , , cord-029547-9ei1ram3 193 38 thus thus RB cord-029547-9ei1ram3 193 39 they -PRON- PRP cord-029547-9ei1ram3 193 40 can can MD cord-029547-9ei1ram3 193 41 also also RB cord-029547-9ei1ram3 193 42 serve serve VB cord-029547-9ei1ram3 193 43 as as IN cord-029547-9ei1ram3 193 44 antiviral antiviral JJ cord-029547-9ei1ram3 193 45 drugs drug NNS cord-029547-9ei1ram3 193 46 for for IN cord-029547-9ei1ram3 193 47 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 193 48 . . . cord-029547-9ei1ram3 194 1 79 79 CD cord-029547-9ei1ram3 194 2 Lopinavir Lopinavir NNP cord-029547-9ei1ram3 194 3 and and CC cord-029547-9ei1ram3 194 4 ritonavir ritonavir NNP cord-029547-9ei1ram3 194 5 are be VBP cord-029547-9ei1ram3 194 6 suppressors suppressor NNS cord-029547-9ei1ram3 194 7 of of IN cord-029547-9ei1ram3 194 8 3-chymotrypsin 3-chymotrypsin CD cord-029547-9ei1ram3 194 9 - - HYPH cord-029547-9ei1ram3 194 10 like like JJ cord-029547-9ei1ram3 194 11 protease protease NN cord-029547-9ei1ram3 194 12 , , , cord-029547-9ei1ram3 194 13 a a DT cord-029547-9ei1ram3 194 14 protease protease NN cord-029547-9ei1ram3 194 15 of of IN cord-029547-9ei1ram3 194 16 coronavirus coronavirus NN cord-029547-9ei1ram3 194 17 . . . cord-029547-9ei1ram3 195 1 Furthermore furthermore RB cord-029547-9ei1ram3 195 2 , , , cord-029547-9ei1ram3 195 3 ritonavir ritonavir NNP cord-029547-9ei1ram3 195 4 suppresses suppress VBZ cord-029547-9ei1ram3 195 5 the the DT cord-029547-9ei1ram3 195 6 activity activity NN cord-029547-9ei1ram3 195 7 of of IN cord-029547-9ei1ram3 195 8 cytochrome cytochrome NN cord-029547-9ei1ram3 195 9 P450 p450 JJ cord-029547-9ei1ram3 195 10 isoenzymes isoenzyme NNS cord-029547-9ei1ram3 195 11 and and CC cord-029547-9ei1ram3 195 12 thus thus RB cord-029547-9ei1ram3 195 13 elevates elevate VBZ cord-029547-9ei1ram3 195 14 plasma plasma NN cord-029547-9ei1ram3 195 15 concentration concentration NN cord-029547-9ei1ram3 195 16 of of IN cord-029547-9ei1ram3 195 17 other other JJ cord-029547-9ei1ram3 195 18 medicines medicine NNS cord-029547-9ei1ram3 195 19 . . . cord-029547-9ei1ram3 196 1 Therefore therefore RB cord-029547-9ei1ram3 196 2 , , , cord-029547-9ei1ram3 196 3 combining combine VBG cord-029547-9ei1ram3 196 4 lopinavir lopinavir NNS cord-029547-9ei1ram3 196 5 and and CC cord-029547-9ei1ram3 196 6 ritonavir ritonavir NNP cord-029547-9ei1ram3 196 7 has have VBZ cord-029547-9ei1ram3 196 8 a a DT cord-029547-9ei1ram3 196 9 good good JJ cord-029547-9ei1ram3 196 10 inhibitory inhibitory JJ cord-029547-9ei1ram3 196 11 effect effect NN cord-029547-9ei1ram3 196 12 on on IN cord-029547-9ei1ram3 196 13 virus virus NN cord-029547-9ei1ram3 196 14 biosynthesis biosynthesis NN cord-029547-9ei1ram3 196 15 , , , cord-029547-9ei1ram3 196 16 which which WDT cord-029547-9ei1ram3 196 17 was be VBD cord-029547-9ei1ram3 196 18 confirmed confirm VBN cord-029547-9ei1ram3 196 19 in in IN cord-029547-9ei1ram3 196 20 the the DT cord-029547-9ei1ram3 196 21 treatment treatment NN cord-029547-9ei1ram3 196 22 of of IN cord-029547-9ei1ram3 196 23 SARS SARS NNP cord-029547-9ei1ram3 196 24 - - HYPH cord-029547-9ei1ram3 196 25 CoV CoV NNP cord-029547-9ei1ram3 196 26 and and CC cord-029547-9ei1ram3 196 27 MERS MERS NNP cord-029547-9ei1ram3 196 28 - - HYPH cord-029547-9ei1ram3 196 29 CoV. CoV. NNP cord-029547-9ei1ram3 196 30 80 80 CD cord-029547-9ei1ram3 197 1 Recently recently RB cord-029547-9ei1ram3 197 2 , , , cord-029547-9ei1ram3 197 3 many many JJ cord-029547-9ei1ram3 197 4 COVID-19 covid-19 JJ cord-029547-9ei1ram3 197 5 patients patient NNS cord-029547-9ei1ram3 197 6 have have VBP cord-029547-9ei1ram3 197 7 received receive VBN cord-029547-9ei1ram3 197 8 lopinavir lopinavir NNS cord-029547-9ei1ram3 197 9 / / SYM cord-029547-9ei1ram3 197 10 ritonavir ritonavir NNP cord-029547-9ei1ram3 197 11 therapy therapy NN cord-029547-9ei1ram3 197 12 and and CC cord-029547-9ei1ram3 197 13 to to IN cord-029547-9ei1ram3 197 14 good good JJ cord-029547-9ei1ram3 197 15 effect effect NN cord-029547-9ei1ram3 197 16 . . . cord-029547-9ei1ram3 198 1 81 81 CD cord-029547-9ei1ram3 199 1 Moreover moreover RB cord-029547-9ei1ram3 199 2 , , , cord-029547-9ei1ram3 199 3 the the DT cord-029547-9ei1ram3 199 4 first first JJ cord-029547-9ei1ram3 199 5 report report NN cord-029547-9ei1ram3 199 6 of of IN cord-029547-9ei1ram3 199 7 the the DT cord-029547-9ei1ram3 199 8 lopinavir lopinavir NNPS cord-029547-9ei1ram3 199 9 / / SYM cord-029547-9ei1ram3 199 10 ritonavir ritonavir NNP cord-029547-9ei1ram3 199 11 clinical clinical JJ cord-029547-9ei1ram3 199 12 trial trial NN cord-029547-9ei1ram3 199 13 results result NNS cord-029547-9ei1ram3 199 14 have have VBP cord-029547-9ei1ram3 199 15 been be VBN cord-029547-9ei1ram3 199 16 published publish VBN cord-029547-9ei1ram3 199 17 on on IN cord-029547-9ei1ram3 199 18 19 19 CD cord-029547-9ei1ram3 199 19 March March NNP cord-029547-9ei1ram3 199 20 2020 2020 CD cord-029547-9ei1ram3 199 21 . . . cord-029547-9ei1ram3 200 1 In in IN cord-029547-9ei1ram3 200 2 that that DT cord-029547-9ei1ram3 200 3 study study NN cord-029547-9ei1ram3 200 4 , , , cord-029547-9ei1ram3 200 5 99 99 CD cord-029547-9ei1ram3 200 6 patients patient NNS cord-029547-9ei1ram3 200 7 were be VBD cord-029547-9ei1ram3 200 8 assigned assign VBN cord-029547-9ei1ram3 200 9 to to IN cord-029547-9ei1ram3 200 10 the the DT cord-029547-9ei1ram3 200 11 lopinavir lopinavir NNS cord-029547-9ei1ram3 200 12 / / SYM cord-029547-9ei1ram3 200 13 ritonavir ritonavir NNP cord-029547-9ei1ram3 200 14 group group NNP cord-029547-9ei1ram3 200 15 and and CC cord-029547-9ei1ram3 200 16 100 100 CD cord-029547-9ei1ram3 200 17 patients patient NNS cord-029547-9ei1ram3 200 18 were be VBD cord-029547-9ei1ram3 200 19 treated treat VBN cord-029547-9ei1ram3 200 20 with with IN cord-029547-9ei1ram3 200 21 the the DT cord-029547-9ei1ram3 200 22 routine routine JJ cord-029547-9ei1ram3 200 23 therapy therapy NN cord-029547-9ei1ram3 200 24 , , , cord-029547-9ei1ram3 200 25 and and CC cord-029547-9ei1ram3 200 26 the the DT cord-029547-9ei1ram3 200 27 median median JJ cord-029547-9ei1ram3 200 28 time time NN cord-029547-9ei1ram3 200 29 of of IN cord-029547-9ei1ram3 200 30 clinical clinical JJ cord-029547-9ei1ram3 200 31 improvement improvement NN cord-029547-9ei1ram3 200 32 was be VBD cord-029547-9ei1ram3 200 33 advanced advance VBN cord-029547-9ei1ram3 200 34 by by IN cord-029547-9ei1ram3 200 35 1 1 CD cord-029547-9ei1ram3 200 36 day day NN cord-029547-9ei1ram3 200 37 when when WRB cord-029547-9ei1ram3 200 38 given give VBN cord-029547-9ei1ram3 200 39 the the DT cord-029547-9ei1ram3 200 40 lopinavir lopinavir NNS cord-029547-9ei1ram3 200 41 / / SYM cord-029547-9ei1ram3 200 42 ritonavir ritonavir NNP cord-029547-9ei1ram3 200 43 treatment treatment NN cord-029547-9ei1ram3 200 44 . . . cord-029547-9ei1ram3 201 1 82 82 CD cord-029547-9ei1ram3 202 1 But but CC cord-029547-9ei1ram3 202 2 it -PRON- PRP cord-029547-9ei1ram3 202 3 failed fail VBD cord-029547-9ei1ram3 202 4 to to TO cord-029547-9ei1ram3 202 5 accelerate accelerate VB cord-029547-9ei1ram3 202 6 clinical clinical JJ cord-029547-9ei1ram3 202 7 improvement improvement NN cord-029547-9ei1ram3 202 8 significantly significantly RB cord-029547-9ei1ram3 202 9 , , , cord-029547-9ei1ram3 202 10 and and CC cord-029547-9ei1ram3 202 11 reduce reduce VB cord-029547-9ei1ram3 202 12 mortality mortality NN cord-029547-9ei1ram3 202 13 and and CC cord-029547-9ei1ram3 202 14 viral viral JJ cord-029547-9ei1ram3 202 15 RNA RNA NNP cord-029547-9ei1ram3 202 16 detected detect VBN cord-029547-9ei1ram3 202 17 in in IN cord-029547-9ei1ram3 202 18 the the DT cord-029547-9ei1ram3 202 19 throat throat NN cord-029547-9ei1ram3 202 20 . . . cord-029547-9ei1ram3 203 1 82 82 CD cord-029547-9ei1ram3 204 1 Similarly similarly RB cord-029547-9ei1ram3 204 2 , , , cord-029547-9ei1ram3 204 3 the the DT cord-029547-9ei1ram3 204 4 clinical clinical JJ cord-029547-9ei1ram3 204 5 trial trial NN cord-029547-9ei1ram3 204 6 in in IN cord-029547-9ei1ram3 204 7 severe severe JJ cord-029547-9ei1ram3 204 8 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 204 9 patients patient NNS cord-029547-9ei1ram3 204 10 indicated indicate VBD cord-029547-9ei1ram3 204 11 lopinavir lopinavir NNP cord-029547-9ei1ram3 204 12 / / SYM cord-029547-9ei1ram3 204 13 ritonavir ritonavir NNP cord-029547-9ei1ram3 204 14 was be VBD cord-029547-9ei1ram3 204 15 of of IN cord-029547-9ei1ram3 204 16 no no DT cord-029547-9ei1ram3 204 17 benefit benefit NN cord-029547-9ei1ram3 204 18 compared compare VBN cord-029547-9ei1ram3 204 19 to to IN cord-029547-9ei1ram3 204 20 standard standard JJ cord-029547-9ei1ram3 204 21 care care NN cord-029547-9ei1ram3 204 22 . . . cord-029547-9ei1ram3 205 1 83 83 CD cord-029547-9ei1ram3 206 1 Therefore therefore RB cord-029547-9ei1ram3 206 2 , , , cord-029547-9ei1ram3 206 3 further further JJ cord-029547-9ei1ram3 206 4 studies study NNS cord-029547-9ei1ram3 206 5 are be VBP cord-029547-9ei1ram3 206 6 needed need VBN cord-029547-9ei1ram3 206 7 to to TO cord-029547-9ei1ram3 206 8 identify identify VB cord-029547-9ei1ram3 206 9 or or CC cord-029547-9ei1ram3 206 10 exclude exclude VB cord-029547-9ei1ram3 206 11 the the DT cord-029547-9ei1ram3 206 12 possible possible JJ cord-029547-9ei1ram3 206 13 benefits benefit NNS cord-029547-9ei1ram3 206 14 of of IN cord-029547-9ei1ram3 206 15 lopinavir lopinavir NNS cord-029547-9ei1ram3 206 16 / / SYM cord-029547-9ei1ram3 206 17 ritonavir ritonavir NNP cord-029547-9ei1ram3 206 18 - - HYPH cord-029547-9ei1ram3 206 19 based base VBN cord-029547-9ei1ram3 206 20 therapies therapy NNS cord-029547-9ei1ram3 206 21 . . . cord-029547-9ei1ram3 207 1 The the DT cord-029547-9ei1ram3 207 2 most most RBS cord-029547-9ei1ram3 207 3 common common JJ cord-029547-9ei1ram3 207 4 antiviral antiviral JJ cord-029547-9ei1ram3 207 5 products product NNS cord-029547-9ei1ram3 207 6 are be VBP cord-029547-9ei1ram3 207 7 IFNs ifn NNS cord-029547-9ei1ram3 207 8 , , , cord-029547-9ei1ram3 207 9 which which WDT cord-029547-9ei1ram3 207 10 induce induce VBP cord-029547-9ei1ram3 207 11 cells cell NNS cord-029547-9ei1ram3 207 12 to to TO cord-029547-9ei1ram3 207 13 synthesize synthesize VB cord-029547-9ei1ram3 207 14 antiviral antiviral JJ cord-029547-9ei1ram3 207 15 proteins protein NNS cord-029547-9ei1ram3 207 16 and and CC cord-029547-9ei1ram3 207 17 thus thus RB cord-029547-9ei1ram3 207 18 inhibit inhibit VB cord-029547-9ei1ram3 207 19 all all DT cord-029547-9ei1ram3 207 20 processes process NNS cord-029547-9ei1ram3 207 21 of of IN cord-029547-9ei1ram3 207 22 the the DT cord-029547-9ei1ram3 207 23 viral viral JJ cord-029547-9ei1ram3 207 24 replication replication NN cord-029547-9ei1ram3 207 25 cycle cycle NN cord-029547-9ei1ram3 207 26 . . . cord-029547-9ei1ram3 208 1 Furthermore furthermore RB cord-029547-9ei1ram3 208 2 , , , cord-029547-9ei1ram3 208 3 it -PRON- PRP cord-029547-9ei1ram3 208 4 could could MD cord-029547-9ei1ram3 208 5 also also RB cord-029547-9ei1ram3 208 6 enhance enhance VB cord-029547-9ei1ram3 208 7 immunity immunity NN cord-029547-9ei1ram3 208 8 of of IN cord-029547-9ei1ram3 208 9 patients patient NNS cord-029547-9ei1ram3 208 10 , , , cord-029547-9ei1ram3 208 11 so so CC cord-029547-9ei1ram3 208 12 it -PRON- PRP cord-029547-9ei1ram3 208 13 is be VBZ cord-029547-9ei1ram3 208 14 widely widely RB cord-029547-9ei1ram3 208 15 used use VBN cord-029547-9ei1ram3 208 16 for for IN cord-029547-9ei1ram3 208 17 therapy therapy NN cord-029547-9ei1ram3 208 18 for for IN cord-029547-9ei1ram3 208 19 multiple multiple JJ cord-029547-9ei1ram3 208 20 viruses virus NNS cord-029547-9ei1ram3 208 21 such such JJ cord-029547-9ei1ram3 208 22 as as IN cord-029547-9ei1ram3 208 23 MERS- MERS- NNP cord-029547-9ei1ram3 209 1 CoV. CoV. NNP cord-029547-9ei1ram3 209 2 84 84 CD cord-029547-9ei1ram3 210 1 In in IN cord-029547-9ei1ram3 210 2 this this DT cord-029547-9ei1ram3 210 3 outbreak outbreak NN cord-029547-9ei1ram3 210 4 , , , cord-029547-9ei1ram3 210 5 IFNs ifn NNS cord-029547-9ei1ram3 210 6 combined combine VBN cord-029547-9ei1ram3 210 7 with with IN cord-029547-9ei1ram3 210 8 antiviral antiviral JJ cord-029547-9ei1ram3 210 9 drugs drug NNS cord-029547-9ei1ram3 210 10 were be VBD cord-029547-9ei1ram3 210 11 recommended recommend VBN cord-029547-9ei1ram3 210 12 to to TO cord-029547-9ei1ram3 210 13 treat treat VB cord-029547-9ei1ram3 210 14 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 210 15 , , , cord-029547-9ei1ram3 210 16 85 85 CD cord-029547-9ei1ram3 210 17 which which WDT cord-029547-9ei1ram3 210 18 has have VBZ cord-029547-9ei1ram3 210 19 achieved achieve VBN cord-029547-9ei1ram3 210 20 good good JJ cord-029547-9ei1ram3 210 21 clinical clinical JJ cord-029547-9ei1ram3 210 22 therapeutic therapeutic JJ cord-029547-9ei1ram3 210 23 effect effect NN cord-029547-9ei1ram3 210 24 . . . cord-029547-9ei1ram3 211 1 Xu Xu NNP cord-029547-9ei1ram3 211 2 et et NNP cord-029547-9ei1ram3 211 3 al al NNP cord-029547-9ei1ram3 211 4 . . NNP cord-029547-9ei1ram3 211 5 reported report VBD cord-029547-9ei1ram3 211 6 that that IN cord-029547-9ei1ram3 211 7 the the DT cord-029547-9ei1ram3 211 8 combination combination NN cord-029547-9ei1ram3 211 9 of of IN cord-029547-9ei1ram3 211 10 IFNs ifn NNS cord-029547-9ei1ram3 211 11 and and CC cord-029547-9ei1ram3 211 12 arbidol arbidol NN cord-029547-9ei1ram3 211 13 or or CC cord-029547-9ei1ram3 211 14 lopinavir lopinavir NNP cord-029547-9ei1ram3 211 15 / / SYM cord-029547-9ei1ram3 211 16 ritonavir ritonavir NNP cord-029547-9ei1ram3 211 17 cured cure VBD cord-029547-9ei1ram3 211 18 62 62 CD cord-029547-9ei1ram3 211 19 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 211 20 patients patient NNS cord-029547-9ei1ram3 211 21 in in IN cord-029547-9ei1ram3 211 22 the the DT cord-029547-9ei1ram3 211 23 Zhejiang Zhejiang NNP cord-029547-9ei1ram3 211 24 province province NN cord-029547-9ei1ram3 211 25 . . . cord-029547-9ei1ram3 212 1 50 50 CD cord-029547-9ei1ram3 213 1 In in IN cord-029547-9ei1ram3 213 2 addition addition NN cord-029547-9ei1ram3 213 3 , , , cord-029547-9ei1ram3 213 4 a a DT cord-029547-9ei1ram3 213 5 combination combination NN cord-029547-9ei1ram3 213 6 use use NN cord-029547-9ei1ram3 213 7 of of IN cord-029547-9ei1ram3 213 8 IFN IFN NNP cord-029547-9ei1ram3 213 9 beta-1b beta-1b NNP cord-029547-9ei1ram3 213 10 , , , cord-029547-9ei1ram3 213 11 ribavirin ribavirin RB cord-029547-9ei1ram3 213 12 , , , cord-029547-9ei1ram3 213 13 and and CC cord-029547-9ei1ram3 213 14 lopinavir lopinavir NNS cord-029547-9ei1ram3 213 15 - - HYPH cord-029547-9ei1ram3 213 16 ritonavir ritonavir NNP cord-029547-9ei1ram3 213 17 was be VBD cord-029547-9ei1ram3 213 18 found find VBN cord-029547-9ei1ram3 213 19 to to TO cord-029547-9ei1ram3 213 20 be be VB cord-029547-9ei1ram3 213 21 more more RBR cord-029547-9ei1ram3 213 22 effective effective JJ cord-029547-9ei1ram3 213 23 than than IN cord-029547-9ei1ram3 213 24 pure pure JJ cord-029547-9ei1ram3 213 25 lopinavir lopinavir NNS cord-029547-9ei1ram3 213 26 - - HYPH cord-029547-9ei1ram3 213 27 ritonavir ritonavir NNS cord-029547-9ei1ram3 213 28 . . . cord-029547-9ei1ram3 214 1 86 86 CD cord-029547-9ei1ram3 215 1 These these DT cord-029547-9ei1ram3 215 2 therapies therapy NNS cord-029547-9ei1ram3 215 3 have have VBP cord-029547-9ei1ram3 215 4 been be VBN cord-029547-9ei1ram3 215 5 initiated initiate VBN cord-029547-9ei1ram3 215 6 into into IN cord-029547-9ei1ram3 215 7 multiple multiple JJ cord-029547-9ei1ram3 215 8 clinical clinical JJ cord-029547-9ei1ram3 215 9 trials trial NNS cord-029547-9ei1ram3 215 10 . . . cord-029547-9ei1ram3 216 1 Convalescent convalescent JJ cord-029547-9ei1ram3 216 2 plasma plasma NN cord-029547-9ei1ram3 216 3 therapy therapy NN cord-029547-9ei1ram3 216 4 ( ( -LRB- cord-029547-9ei1ram3 216 5 CPT CPT NNP cord-029547-9ei1ram3 216 6 ) ) -RRB- cord-029547-9ei1ram3 216 7 is be VBZ cord-029547-9ei1ram3 216 8 based base VBN cord-029547-9ei1ram3 216 9 on on IN cord-029547-9ei1ram3 216 10 the the DT cord-029547-9ei1ram3 216 11 principle principle NN cord-029547-9ei1ram3 216 12 of of IN cord-029547-9ei1ram3 216 13 using use VBG cord-029547-9ei1ram3 216 14 a a DT cord-029547-9ei1ram3 216 15 certain certain JJ cord-029547-9ei1ram3 216 16 titer titer NN cord-029547-9ei1ram3 216 17 of of IN cord-029547-9ei1ram3 216 18 viral viral JJ cord-029547-9ei1ram3 216 19 - - HYPH cord-029547-9ei1ram3 216 20 specific specific JJ cord-029547-9ei1ram3 216 21 antibodies antibody NNS cord-029547-9ei1ram3 216 22 in in IN cord-029547-9ei1ram3 216 23 the the DT cord-029547-9ei1ram3 216 24 recovered recovered JJ cord-029547-9ei1ram3 216 25 plasma plasma NN cord-029547-9ei1ram3 216 26 to to TO cord-029547-9ei1ram3 216 27 obtain obtain VB cord-029547-9ei1ram3 216 28 passive passive JJ cord-029547-9ei1ram3 216 29 immunity immunity NN cord-029547-9ei1ram3 216 30 , , , cord-029547-9ei1ram3 216 31 neutralize neutralize VB cord-029547-9ei1ram3 216 32 specific specific JJ cord-029547-9ei1ram3 216 33 pathogens pathogen NNS cord-029547-9ei1ram3 216 34 , , , cord-029547-9ei1ram3 216 35 and and CC cord-029547-9ei1ram3 216 36 eventually eventually RB cord-029547-9ei1ram3 216 37 clear clear VB cord-029547-9ei1ram3 216 38 the the DT cord-029547-9ei1ram3 216 39 pathogens pathogen NNS cord-029547-9ei1ram3 216 40 in in IN cord-029547-9ei1ram3 216 41 blood blood NN cord-029547-9ei1ram3 216 42 circulation circulation NN cord-029547-9ei1ram3 216 43 , , , cord-029547-9ei1ram3 216 44 thus thus RB cord-029547-9ei1ram3 216 45 achieving achieve VBG cord-029547-9ei1ram3 216 46 the the DT cord-029547-9ei1ram3 216 47 treatment treatment NN cord-029547-9ei1ram3 216 48 expectation expectation NN cord-029547-9ei1ram3 216 49 . . . cord-029547-9ei1ram3 217 1 87 87 CD cord-029547-9ei1ram3 218 1 Luckily luckily RB cord-029547-9ei1ram3 218 2 , , , cord-029547-9ei1ram3 218 3 key key JJ cord-029547-9ei1ram3 218 4 indicators indicator NNS cord-029547-9ei1ram3 218 5 of of IN cord-029547-9ei1ram3 218 6 laboratory laboratory NN cord-029547-9ei1ram3 218 7 testing testing NN cord-029547-9ei1ram3 218 8 , , , cord-029547-9ei1ram3 218 9 clinical clinical JJ cord-029547-9ei1ram3 218 10 signs sign NNS cord-029547-9ei1ram3 218 11 , , , cord-029547-9ei1ram3 218 12 and and CC cord-029547-9ei1ram3 218 13 symptoms symptom NNS cord-029547-9ei1ram3 218 14 of of IN cord-029547-9ei1ram3 218 15 several several JJ cord-029547-9ei1ram3 218 16 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 218 17 patients patient NNS cord-029547-9ei1ram3 218 18 were be VBD cord-029547-9ei1ram3 218 19 confirmed confirm VBN cord-029547-9ei1ram3 218 20 to to TO cord-029547-9ei1ram3 218 21 improve improve VB cord-029547-9ei1ram3 218 22 significantly significantly RB cord-029547-9ei1ram3 218 23 after after IN cord-029547-9ei1ram3 218 24 CPT CPT NNP cord-029547-9ei1ram3 218 25 , , , cord-029547-9ei1ram3 218 26 88 88 CD cord-029547-9ei1ram3 219 1 so so CC cord-029547-9ei1ram3 219 2 CPT CPT NNP cord-029547-9ei1ram3 219 3 is be VBZ cord-029547-9ei1ram3 219 4 recommended recommend VBN cord-029547-9ei1ram3 219 5 for for IN cord-029547-9ei1ram3 219 6 COVID-19 covid-19 JJ cord-029547-9ei1ram3 219 7 treatment treatment NN cord-029547-9ei1ram3 219 8 . . . cord-029547-9ei1ram3 220 1 Currently currently RB cord-029547-9ei1ram3 220 2 , , , cord-029547-9ei1ram3 220 3 clinical clinical JJ cord-029547-9ei1ram3 220 4 trials trial NNS cord-029547-9ei1ram3 220 5 are be VBP cord-029547-9ei1ram3 220 6 under under IN cord-029547-9ei1ram3 220 7 way way NN cord-029547-9ei1ram3 220 8 to to TO cord-029547-9ei1ram3 220 9 further further RB cord-029547-9ei1ram3 220 10 evaluate evaluate VB cord-029547-9ei1ram3 220 11 the the DT cord-029547-9ei1ram3 220 12 efficiency efficiency NN cord-029547-9ei1ram3 220 13 and and CC cord-029547-9ei1ram3 220 14 safety safety NN cord-029547-9ei1ram3 220 15 of of IN cord-029547-9ei1ram3 220 16 CPT CPT NNP cord-029547-9ei1ram3 220 17 to to IN cord-029547-9ei1ram3 220 18 COVID-19 covid-19 VB cord-029547-9ei1ram3 220 19 . . . cord-029547-9ei1ram3 221 1 The the DT cord-029547-9ei1ram3 221 2 monoclonal monoclonal JJ cord-029547-9ei1ram3 221 3 antibody antibody NN cord-029547-9ei1ram3 221 4 is be VBZ cord-029547-9ei1ram3 221 5 a a DT cord-029547-9ei1ram3 221 6 highly highly RB cord-029547-9ei1ram3 221 7 uniform uniform JJ cord-029547-9ei1ram3 221 8 antibody antibody NN cord-029547-9ei1ram3 221 9 that that WDT cord-029547-9ei1ram3 221 10 is be VBZ cord-029547-9ei1ram3 221 11 produced produce VBN cord-029547-9ei1ram3 221 12 by by IN cord-029547-9ei1ram3 221 13 a a DT cord-029547-9ei1ram3 221 14 single single JJ cord-029547-9ei1ram3 221 15 B b NN cord-029547-9ei1ram3 221 16 cell cell NN cord-029547-9ei1ram3 221 17 and and CC cord-029547-9ei1ram3 221 18 specific specific JJ cord-029547-9ei1ram3 221 19 to to TO cord-029547-9ei1ram3 221 20 target target VB cord-029547-9ei1ram3 221 21 the the DT cord-029547-9ei1ram3 221 22 antigen antigen NN cord-029547-9ei1ram3 221 23 epitopes epitope NNS cord-029547-9ei1ram3 221 24 , , , cord-029547-9ei1ram3 221 25 which which WDT cord-029547-9ei1ram3 221 26 have have VBP cord-029547-9ei1ram3 221 27 been be VBN cord-029547-9ei1ram3 221 28 confirmed confirm VBN cord-029547-9ei1ram3 221 29 to to TO cord-029547-9ei1ram3 221 30 suppress suppress VB cord-029547-9ei1ram3 221 31 viruses virus NNS cord-029547-9ei1ram3 221 32 entering enter VBG cord-029547-9ei1ram3 221 33 host host NN cord-029547-9ei1ram3 221 34 cells cell NNS cord-029547-9ei1ram3 221 35 extracellularly extracellularly RB cord-029547-9ei1ram3 221 36 for for IN cord-029547-9ei1ram3 221 37 many many JJ cord-029547-9ei1ram3 221 38 coronaviruses coronaviruse NNS cord-029547-9ei1ram3 221 39 including include VBG cord-029547-9ei1ram3 221 40 SARS SARS NNP cord-029547-9ei1ram3 221 41 - - HYPH cord-029547-9ei1ram3 221 42 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 221 43 . . . cord-029547-9ei1ram3 222 1 89 89 CD cord-029547-9ei1ram3 222 2 _SP cord-029547-9ei1ram3 223 1 Like like IN cord-029547-9ei1ram3 223 2 most most JJS cord-029547-9ei1ram3 223 3 diseases disease NNS cord-029547-9ei1ram3 223 4 , , , cord-029547-9ei1ram3 223 5 the the DT cord-029547-9ei1ram3 223 6 main main JJ cord-029547-9ei1ram3 223 7 treatments treatment NNS cord-029547-9ei1ram3 223 8 of of IN cord-029547-9ei1ram3 223 9 the the DT cord-029547-9ei1ram3 223 10 complications complication NNS cord-029547-9ei1ram3 223 11 of of IN cord-029547-9ei1ram3 223 12 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 223 13 are be VBP cord-029547-9ei1ram3 223 14 to to TO cord-029547-9ei1ram3 223 15 strengthen strengthen VB cord-029547-9ei1ram3 223 16 supportive supportive JJ cord-029547-9ei1ram3 223 17 treatment treatment NN cord-029547-9ei1ram3 223 18 , , , cord-029547-9ei1ram3 223 19 ensure ensure VB cord-029547-9ei1ram3 223 20 adequate adequate JJ cord-029547-9ei1ram3 223 21 energy energy NN cord-029547-9ei1ram3 223 22 , , , cord-029547-9ei1ram3 223 23 and and CC cord-029547-9ei1ram3 223 24 pay pay VB cord-029547-9ei1ram3 223 25 attention attention NN cord-029547-9ei1ram3 223 26 to to IN cord-029547-9ei1ram3 223 27 water water NN cord-029547-9ei1ram3 223 28 and and CC cord-029547-9ei1ram3 223 29 electrolyte electrolyte JJ cord-029547-9ei1ram3 223 30 balance balance NN cord-029547-9ei1ram3 223 31 to to TO cord-029547-9ei1ram3 223 32 maintain maintain VB cord-029547-9ei1ram3 223 33 internal internal JJ cord-029547-9ei1ram3 223 34 environment environment NN cord-029547-9ei1ram3 223 35 homeostasis homeostasis NN cord-029547-9ei1ram3 223 36 . . . cord-029547-9ei1ram3 224 1 55 55 CD cord-029547-9ei1ram3 225 1 For for IN cord-029547-9ei1ram3 225 2 COVID-19 covid-19 NN cord-029547-9ei1ram3 225 3 , , , cord-029547-9ei1ram3 225 4 hypoxia hypoxia NN cord-029547-9ei1ram3 225 5 is be VBZ cord-029547-9ei1ram3 225 6 a a DT cord-029547-9ei1ram3 225 7 typical typical JJ cord-029547-9ei1ram3 225 8 clinical clinical JJ cord-029547-9ei1ram3 225 9 symptom symptom NN cord-029547-9ei1ram3 225 10 of of IN cord-029547-9ei1ram3 225 11 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 225 12 , , , cord-029547-9ei1ram3 225 13 thus thus RB cord-029547-9ei1ram3 225 14 oxygen oxygen NN cord-029547-9ei1ram3 225 15 inhalation inhalation NN cord-029547-9ei1ram3 225 16 is be VBZ cord-029547-9ei1ram3 225 17 the the DT cord-029547-9ei1ram3 225 18 essential essential JJ cord-029547-9ei1ram3 225 19 treatment treatment NN cord-029547-9ei1ram3 225 20 for for IN cord-029547-9ei1ram3 225 21 both both CC cord-029547-9ei1ram3 225 22 mild mild JJ cord-029547-9ei1ram3 225 23 and and CC cord-029547-9ei1ram3 225 24 severe severe JJ cord-029547-9ei1ram3 225 25 patients patient NNS cord-029547-9ei1ram3 225 26 . . . cord-029547-9ei1ram3 226 1 92 92 CD cord-029547-9ei1ram3 226 2 , , , cord-029547-9ei1ram3 226 3 93 93 CD cord-029547-9ei1ram3 227 1 It -PRON- PRP cord-029547-9ei1ram3 227 2 is be VBZ cord-029547-9ei1ram3 227 3 worth worth JJ cord-029547-9ei1ram3 227 4 noting note VBG cord-029547-9ei1ram3 227 5 that that IN cord-029547-9ei1ram3 227 6 severe severe JJ cord-029547-9ei1ram3 227 7 cases case NNS cord-029547-9ei1ram3 227 8 of of IN cord-029547-9ei1ram3 227 9 COVID-19 COVID-19 , cord-029547-9ei1ram3 227 10 often often RB cord-029547-9ei1ram3 227 11 develop develop VBP cord-029547-9ei1ram3 227 12 severe severe JJ cord-029547-9ei1ram3 227 13 inflammation inflammation NN cord-029547-9ei1ram3 227 14 , , , cord-029547-9ei1ram3 227 15 shock shock NN cord-029547-9ei1ram3 227 16 , , , cord-029547-9ei1ram3 227 17 combination combination NN cord-029547-9ei1ram3 227 18 of of IN cord-029547-9ei1ram3 227 19 bacterial bacterial JJ cord-029547-9ei1ram3 227 20 infection infection NN cord-029547-9ei1ram3 227 21 , , , cord-029547-9ei1ram3 227 22 and and CC cord-029547-9ei1ram3 227 23 severe severe JJ cord-029547-9ei1ram3 227 24 kidney kidney NN cord-029547-9ei1ram3 227 25 damage damage NN cord-029547-9ei1ram3 227 26 as as RB cord-029547-9ei1ram3 227 27 well well RB cord-029547-9ei1ram3 227 28 as as IN cord-029547-9ei1ram3 227 29 acute acute JJ cord-029547-9ei1ram3 227 30 respiratory respiratory JJ cord-029547-9ei1ram3 227 31 distress distress NN cord-029547-9ei1ram3 227 32 syndrome syndrome NN cord-029547-9ei1ram3 227 33 ( ( -LRB- cord-029547-9ei1ram3 227 34 ARDS ARDS NNP cord-029547-9ei1ram3 227 35 ) ) -RRB- cord-029547-9ei1ram3 227 36 , , , cord-029547-9ei1ram3 227 37 which which WDT cord-029547-9ei1ram3 227 38 often often RB cord-029547-9ei1ram3 227 39 result result VBP cord-029547-9ei1ram3 227 40 in in IN cord-029547-9ei1ram3 227 41 death death NN cord-029547-9ei1ram3 227 42 . . . cord-029547-9ei1ram3 228 1 94 94 CD cord-029547-9ei1ram3 229 1 Thus thus RB cord-029547-9ei1ram3 229 2 , , , cord-029547-9ei1ram3 229 3 timely timely JJ cord-029547-9ei1ram3 229 4 complications complication NNS cord-029547-9ei1ram3 229 5 treatment treatment NN cord-029547-9ei1ram3 229 6 is be VBZ cord-029547-9ei1ram3 229 7 necessary necessary JJ cord-029547-9ei1ram3 229 8 for for IN cord-029547-9ei1ram3 229 9 critical critical JJ cord-029547-9ei1ram3 229 10 patients patient NNS cord-029547-9ei1ram3 229 11 . . . cord-029547-9ei1ram3 230 1 Glucocorticoids Glucocorticoids NNP cord-029547-9ei1ram3 230 2 such such JJ cord-029547-9ei1ram3 230 3 as as IN cord-029547-9ei1ram3 230 4 methylprednisolone methylprednisolone NN cord-029547-9ei1ram3 230 5 and and CC cord-029547-9ei1ram3 230 6 dexamethasone dexamethasone NN cord-029547-9ei1ram3 230 7 have have VBP cord-029547-9ei1ram3 230 8 strong strong JJ cord-029547-9ei1ram3 230 9 anti anti JJ cord-029547-9ei1ram3 230 10 - - JJ cord-029547-9ei1ram3 230 11 inflammatory inflammatory JJ cord-029547-9ei1ram3 230 12 as as RB cord-029547-9ei1ram3 230 13 well well RB cord-029547-9ei1ram3 230 14 as as IN cord-029547-9ei1ram3 230 15 antishock antishock NN cord-029547-9ei1ram3 230 16 effects effect NNS cord-029547-9ei1ram3 230 17 , , , cord-029547-9ei1ram3 230 18 so so IN cord-029547-9ei1ram3 230 19 they -PRON- PRP cord-029547-9ei1ram3 230 20 are be VBP cord-029547-9ei1ram3 230 21 usually usually RB cord-029547-9ei1ram3 230 22 used use VBN cord-029547-9ei1ram3 230 23 to to TO cord-029547-9ei1ram3 230 24 save save VB cord-029547-9ei1ram3 230 25 critical critical JJ cord-029547-9ei1ram3 230 26 patients patient NNS cord-029547-9ei1ram3 230 27 , , , cord-029547-9ei1ram3 230 28 especially especially RB cord-029547-9ei1ram3 230 29 patients patient NNS cord-029547-9ei1ram3 230 30 with with IN cord-029547-9ei1ram3 230 31 ARDS ARDS NNP cord-029547-9ei1ram3 230 32 . . . cord-029547-9ei1ram3 231 1 95 95 CD cord-029547-9ei1ram3 232 1 However however RB cord-029547-9ei1ram3 232 2 , , , cord-029547-9ei1ram3 232 3 they -PRON- PRP cord-029547-9ei1ram3 232 4 suppress suppress VBP cord-029547-9ei1ram3 232 5 immunity immunity NN cord-029547-9ei1ram3 232 6 , , , cord-029547-9ei1ram3 232 7 cause cause VB cord-029547-9ei1ram3 232 8 femoral femoral JJ cord-029547-9ei1ram3 232 9 head head NN cord-029547-9ei1ram3 232 10 necrosis necrosis NN cord-029547-9ei1ram3 232 11 of of IN cord-029547-9ei1ram3 232 12 patients patient NNS cord-029547-9ei1ram3 232 13 , , , cord-029547-9ei1ram3 232 14 and and CC cord-029547-9ei1ram3 232 15 can can MD cord-029547-9ei1ram3 232 16 not not RB cord-029547-9ei1ram3 232 17 save save VB cord-029547-9ei1ram3 232 18 patients patient NNS cord-029547-9ei1ram3 232 19 with with IN cord-029547-9ei1ram3 232 20 shock shock NN cord-029547-9ei1ram3 232 21 who who WP cord-029547-9ei1ram3 232 22 have have VBP cord-029547-9ei1ram3 232 23 increased increase VBN cord-029547-9ei1ram3 232 24 intrathoracic intrathoracic JJ cord-029547-9ei1ram3 232 25 pressure pressure NN cord-029547-9ei1ram3 232 26 , , , cord-029547-9ei1ram3 232 27 thus thus RB cord-029547-9ei1ram3 232 28 WHO who WP cord-029547-9ei1ram3 232 29 did do VBD cord-029547-9ei1ram3 232 30 not not RB cord-029547-9ei1ram3 232 31 recommend recommend VB cord-029547-9ei1ram3 232 32 using use VBG cord-029547-9ei1ram3 232 33 glucocorticoids glucocorticoid NNS cord-029547-9ei1ram3 232 34 initially initially RB cord-029547-9ei1ram3 232 35 . . . cord-029547-9ei1ram3 233 1 96 96 CD cord-029547-9ei1ram3 234 1 For for IN cord-029547-9ei1ram3 234 2 these these DT cord-029547-9ei1ram3 234 3 situations situation NNS cord-029547-9ei1ram3 234 4 , , , cord-029547-9ei1ram3 234 5 physicians physician NNS cord-029547-9ei1ram3 234 6 suggested suggest VBD cord-029547-9ei1ram3 234 7 that that IN cord-029547-9ei1ram3 234 8 short short JJ cord-029547-9ei1ram3 234 9 - - HYPH cord-029547-9ei1ram3 234 10 term term NN cord-029547-9ei1ram3 234 11 administration administration NN cord-029547-9ei1ram3 234 12 of of IN cord-029547-9ei1ram3 234 13 glucocorticoids glucocorticoid NNS cord-029547-9ei1ram3 234 14 should should MD cord-029547-9ei1ram3 234 15 be be VB cord-029547-9ei1ram3 234 16 adopted adopt VBN cord-029547-9ei1ram3 234 17 to to TO cord-029547-9ei1ram3 234 18 decrease decrease VB cord-029547-9ei1ram3 234 19 the the DT cord-029547-9ei1ram3 234 20 side side NN cord-029547-9ei1ram3 234 21 effects effect NNS cord-029547-9ei1ram3 234 22 . . . cord-029547-9ei1ram3 235 1 97 97 CD cord-029547-9ei1ram3 236 1 Moreover moreover RB cord-029547-9ei1ram3 236 2 , , , cord-029547-9ei1ram3 236 3 considering consider VBG cord-029547-9ei1ram3 236 4 the the DT cord-029547-9ei1ram3 236 5 immunosuppressive immunosuppressive JJ cord-029547-9ei1ram3 236 6 action action NN cord-029547-9ei1ram3 236 7 , , , cord-029547-9ei1ram3 236 8 immune immune JJ cord-029547-9ei1ram3 236 9 boosters booster NNS cord-029547-9ei1ram3 236 10 such such JJ cord-029547-9ei1ram3 236 11 as as IN cord-029547-9ei1ram3 236 12 α α NN cord-029547-9ei1ram3 236 13 - - HYPH cord-029547-9ei1ram3 236 14 IFN IFN NNP cord-029547-9ei1ram3 236 15 and and CC cord-029547-9ei1ram3 236 16 thymosin thymosin NN cord-029547-9ei1ram3 236 17 are be VBP cord-029547-9ei1ram3 236 18 important important JJ cord-029547-9ei1ram3 236 19 for for IN cord-029547-9ei1ram3 236 20 use use NN cord-029547-9ei1ram3 236 21 in in IN cord-029547-9ei1ram3 236 22 avoiding avoid VBG cord-029547-9ei1ram3 236 23 adverse adverse JJ cord-029547-9ei1ram3 236 24 events event NNS cord-029547-9ei1ram3 236 25 . . . cord-029547-9ei1ram3 237 1 For for IN cord-029547-9ei1ram3 237 2 severe severe JJ cord-029547-9ei1ram3 237 3 cytokine cytokine NN cord-029547-9ei1ram3 237 4 storms storm NNS cord-029547-9ei1ram3 237 5 , , , cord-029547-9ei1ram3 237 6 simple simple JJ cord-029547-9ei1ram3 237 7 glucocorticoids glucocorticoid NNS cord-029547-9ei1ram3 237 8 can can MD cord-029547-9ei1ram3 237 9 not not RB cord-029547-9ei1ram3 237 10 suppress suppress VB cord-029547-9ei1ram3 237 11 the the DT cord-029547-9ei1ram3 237 12 inflammation inflammation NN cord-029547-9ei1ram3 237 13 efficiently efficiently RB cord-029547-9ei1ram3 237 14 , , , cord-029547-9ei1ram3 237 15 so so RB cord-029547-9ei1ram3 237 16 potent potent JJ cord-029547-9ei1ram3 237 17 blood blood NN cord-029547-9ei1ram3 237 18 purification purification NN cord-029547-9ei1ram3 237 19 measures measure NNS cord-029547-9ei1ram3 237 20 such such JJ cord-029547-9ei1ram3 237 21 as as IN cord-029547-9ei1ram3 237 22 an an DT cord-029547-9ei1ram3 237 23 artificial artificial JJ cord-029547-9ei1ram3 237 24 liver liver NN cord-029547-9ei1ram3 237 25 system system NN cord-029547-9ei1ram3 237 26 are be VBP cord-029547-9ei1ram3 237 27 essential essential JJ cord-029547-9ei1ram3 237 28 . . . cord-029547-9ei1ram3 238 1 98 98 CD cord-029547-9ei1ram3 239 1 The the DT cord-029547-9ei1ram3 239 2 processes process NNS cord-029547-9ei1ram3 239 3 of of IN cord-029547-9ei1ram3 239 4 urgent urgent JJ cord-029547-9ei1ram3 239 5 antishock antishock NN cord-029547-9ei1ram3 239 6 therapy therapy NN cord-029547-9ei1ram3 239 7 mainly mainly RB cord-029547-9ei1ram3 239 8 contain contain VBP cord-029547-9ei1ram3 239 9 complements complement NNS cord-029547-9ei1ram3 239 10 of of IN cord-029547-9ei1ram3 239 11 blood blood NN cord-029547-9ei1ram3 239 12 volume volume NN cord-029547-9ei1ram3 239 13 , , , cord-029547-9ei1ram3 239 14 improving improve VBG cord-029547-9ei1ram3 239 15 cardiac cardiac JJ cord-029547-9ei1ram3 239 16 contractility contractility NN cord-029547-9ei1ram3 239 17 and and CC cord-029547-9ei1ram3 239 18 vascular vascular JJ cord-029547-9ei1ram3 239 19 activity activity NN cord-029547-9ei1ram3 239 20 , , , cord-029547-9ei1ram3 239 21 thus thus RB cord-029547-9ei1ram3 239 22 vasoactive vasoactive JJ cord-029547-9ei1ram3 239 23 agents agent NNS cord-029547-9ei1ram3 239 24 and and CC cord-029547-9ei1ram3 239 25 positive positive JJ cord-029547-9ei1ram3 239 26 inotropic inotropic JJ cord-029547-9ei1ram3 239 27 drugs drug NNS cord-029547-9ei1ram3 239 28 such such JJ cord-029547-9ei1ram3 239 29 as as IN cord-029547-9ei1ram3 239 30 epinephrine epinephrine NN cord-029547-9ei1ram3 239 31 , , , cord-029547-9ei1ram3 239 32 dopamine dopamine NN cord-029547-9ei1ram3 239 33 , , , cord-029547-9ei1ram3 239 34 and and CC cord-029547-9ei1ram3 239 35 norepinephrine norepinephrine NN cord-029547-9ei1ram3 239 36 99 99 CD cord-029547-9ei1ram3 239 37 are be VBP cord-029547-9ei1ram3 239 38 necessary necessary JJ cord-029547-9ei1ram3 239 39 for for IN cord-029547-9ei1ram3 239 40 first first JJ cord-029547-9ei1ram3 239 41 aid aid NN cord-029547-9ei1ram3 239 42 of of IN cord-029547-9ei1ram3 239 43 critical critical JJ cord-029547-9ei1ram3 239 44 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 239 45 patients patient NNS cord-029547-9ei1ram3 239 46 . . . cord-029547-9ei1ram3 240 1 For for IN cord-029547-9ei1ram3 240 2 patients patient NNS cord-029547-9ei1ram3 240 3 with with IN cord-029547-9ei1ram3 240 4 severe severe JJ cord-029547-9ei1ram3 240 5 kidney kidney NN cord-029547-9ei1ram3 240 6 damage damage NN cord-029547-9ei1ram3 240 7 , , , cord-029547-9ei1ram3 240 8 we -PRON- PRP cord-029547-9ei1ram3 240 9 should should MD cord-029547-9ei1ram3 240 10 actively actively RB cord-029547-9ei1ram3 240 11 search search VB cord-029547-9ei1ram3 240 12 for for IN cord-029547-9ei1ram3 240 13 the the DT cord-029547-9ei1ram3 240 14 primary primary JJ cord-029547-9ei1ram3 240 15 cause cause NN cord-029547-9ei1ram3 240 16 and and CC cord-029547-9ei1ram3 240 17 pay pay VB cord-029547-9ei1ram3 240 18 attention attention NN cord-029547-9ei1ram3 240 19 to to IN cord-029547-9ei1ram3 240 20 the the DT cord-029547-9ei1ram3 240 21 water water NN cord-029547-9ei1ram3 240 22 , , , cord-029547-9ei1ram3 240 23 electrolyte electrolyte NN cord-029547-9ei1ram3 240 24 , , , cord-029547-9ei1ram3 240 25 and and CC cord-029547-9ei1ram3 240 26 acid acid NN cord-029547-9ei1ram3 240 27 - - HYPH cord-029547-9ei1ram3 240 28 base base NN cord-029547-9ei1ram3 240 29 balance balance NN cord-029547-9ei1ram3 240 30 . . . cord-029547-9ei1ram3 241 1 When when WRB cord-029547-9ei1ram3 241 2 homeostasis homeostasis NN cord-029547-9ei1ram3 241 3 is be VBZ cord-029547-9ei1ram3 241 4 decompensated decompensate VBN cord-029547-9ei1ram3 241 5 and/or and/or CC cord-029547-9ei1ram3 241 6 multiple multiple JJ cord-029547-9ei1ram3 241 7 organ organ NN cord-029547-9ei1ram3 241 8 failure failure NN cord-029547-9ei1ram3 241 9 occurs occur VBZ cord-029547-9ei1ram3 241 10 , , , cord-029547-9ei1ram3 241 11 continuous continuous JJ cord-029547-9ei1ram3 241 12 renal renal JJ cord-029547-9ei1ram3 241 13 replacement replacement NN cord-029547-9ei1ram3 241 14 therapy therapy NN cord-029547-9ei1ram3 241 15 ( ( -LRB- cord-029547-9ei1ram3 241 16 CRRT CRRT NNP cord-029547-9ei1ram3 241 17 ) ) -RRB- cord-029547-9ei1ram3 241 18 should should MD cord-029547-9ei1ram3 241 19 be be VB cord-029547-9ei1ram3 241 20 adopted adopt VBN cord-029547-9ei1ram3 241 21 for for IN cord-029547-9ei1ram3 241 22 treatment treatment NN cord-029547-9ei1ram3 241 23 . . . cord-029547-9ei1ram3 242 1 100 100 CD cord-029547-9ei1ram3 242 2 ARDS ARDS NNP cord-029547-9ei1ram3 242 3 is be VBZ cord-029547-9ei1ram3 242 4 one one CD cord-029547-9ei1ram3 242 5 of of IN cord-029547-9ei1ram3 242 6 most most JJS cord-029547-9ei1ram3 242 7 critical critical JJ cord-029547-9ei1ram3 242 8 complications complication NNS cord-029547-9ei1ram3 242 9 for for IN cord-029547-9ei1ram3 242 10 patients patient NNS cord-029547-9ei1ram3 242 11 , , , cord-029547-9ei1ram3 242 12 which which WDT cord-029547-9ei1ram3 242 13 is be VBZ cord-029547-9ei1ram3 242 14 known know VBN cord-029547-9ei1ram3 242 15 for for IN cord-029547-9ei1ram3 242 16 its -PRON- PRP$ cord-029547-9ei1ram3 242 17 high high JJ cord-029547-9ei1ram3 242 18 mortality mortality NN cord-029547-9ei1ram3 242 19 rate rate NN cord-029547-9ei1ram3 242 20 , , , cord-029547-9ei1ram3 242 21 especially especially RB cord-029547-9ei1ram3 242 22 for for IN cord-029547-9ei1ram3 242 23 pregnant pregnant JJ cord-029547-9ei1ram3 242 24 patients patient NNS cord-029547-9ei1ram3 242 25 . . . cord-029547-9ei1ram3 243 1 101 101 CD cord-029547-9ei1ram3 244 1 For for IN cord-029547-9ei1ram3 244 2 its -PRON- PRP$ cord-029547-9ei1ram3 244 3 therapy therapy NN cord-029547-9ei1ram3 244 4 , , , cord-029547-9ei1ram3 244 5 ECMO ECMO NNP cord-029547-9ei1ram3 244 6 is be VBZ cord-029547-9ei1ram3 244 7 usually usually RB cord-029547-9ei1ram3 244 8 recommended recommend VBN cord-029547-9ei1ram3 244 9 and and CC cord-029547-9ei1ram3 244 10 has have VBZ cord-029547-9ei1ram3 244 11 a a DT cord-029547-9ei1ram3 244 12 certain certain JJ cord-029547-9ei1ram3 244 13 curative curative JJ cord-029547-9ei1ram3 244 14 effect effect NN cord-029547-9ei1ram3 244 15 . . . cord-029547-9ei1ram3 245 1 102 102 CD cord-029547-9ei1ram3 246 1 However however RB cord-029547-9ei1ram3 246 2 , , , cord-029547-9ei1ram3 246 3 its -PRON- PRP$ cord-029547-9ei1ram3 246 4 complex complex JJ cord-029547-9ei1ram3 246 5 operation operation NN cord-029547-9ei1ram3 246 6 and and CC cord-029547-9ei1ram3 246 7 low low JJ cord-029547-9ei1ram3 246 8 cure cure NN cord-029547-9ei1ram3 246 9 rate rate NN cord-029547-9ei1ram3 246 10 make make VBP cord-029547-9ei1ram3 246 11 it -PRON- PRP cord-029547-9ei1ram3 246 12 difficult difficult JJ cord-029547-9ei1ram3 246 13 to to TO cord-029547-9ei1ram3 246 14 perform perform VB cord-029547-9ei1ram3 246 15 in in IN cord-029547-9ei1ram3 246 16 a a DT cord-029547-9ei1ram3 246 17 primary primary JJ cord-029547-9ei1ram3 246 18 hospital hospital NN cord-029547-9ei1ram3 246 19 . . . cord-029547-9ei1ram3 247 1 Luckily luckily RB cord-029547-9ei1ram3 247 2 , , , cord-029547-9ei1ram3 247 3 stem stem NN cord-029547-9ei1ram3 247 4 cells cell NNS cord-029547-9ei1ram3 247 5 and and CC cord-029547-9ei1ram3 247 6 their -PRON- PRP$ cord-029547-9ei1ram3 247 7 extracellular extracellular JJ cord-029547-9ei1ram3 247 8 vesicles vesicle NNS cord-029547-9ei1ram3 247 9 are be VBP cord-029547-9ei1ram3 247 10 able able JJ cord-029547-9ei1ram3 247 11 to to TO cord-029547-9ei1ram3 247 12 repair repair VB cord-029547-9ei1ram3 247 13 the the DT cord-029547-9ei1ram3 247 14 damage damage NN cord-029547-9ei1ram3 247 15 and and CC cord-029547-9ei1ram3 247 16 relieve relieve VB cord-029547-9ei1ram3 247 17 lung lung NN cord-029547-9ei1ram3 247 18 symptoms symptom NNS cord-029547-9ei1ram3 247 19 , , , cord-029547-9ei1ram3 247 20 thus thus RB cord-029547-9ei1ram3 247 21 they -PRON- PRP cord-029547-9ei1ram3 247 22 have have VBP cord-029547-9ei1ram3 247 23 been be VBN cord-029547-9ei1ram3 247 24 used use VBN cord-029547-9ei1ram3 247 25 to to TO cord-029547-9ei1ram3 247 26 cure cure VB cord-029547-9ei1ram3 247 27 ARDS ARDS NNP cord-029547-9ei1ram3 247 28 . . . cord-029547-9ei1ram3 248 1 103 103 CD cord-029547-9ei1ram3 249 1 Currently currently RB cord-029547-9ei1ram3 249 2 , , , cord-029547-9ei1ram3 249 3 some some DT cord-029547-9ei1ram3 249 4 COVID-19 covid-19 CD cord-029547-9ei1ram3 249 5 patients patient NNS cord-029547-9ei1ram3 249 6 have have VBP cord-029547-9ei1ram3 249 7 been be VBN cord-029547-9ei1ram3 249 8 treated treat VBN cord-029547-9ei1ram3 249 9 with with IN cord-029547-9ei1ram3 249 10 umbilical umbilical JJ cord-029547-9ei1ram3 249 11 cord cord NN cord-029547-9ei1ram3 249 12 mesenchymal mesenchymal JJ cord-029547-9ei1ram3 249 13 stem stem NN cord-029547-9ei1ram3 249 14 cells cell NNS cord-029547-9ei1ram3 249 15 and and CC cord-029547-9ei1ram3 249 16 achieved achieve VBN cord-029547-9ei1ram3 249 17 good good JJ cord-029547-9ei1ram3 249 18 effects effect NNS cord-029547-9ei1ram3 249 19 . . . cord-029547-9ei1ram3 250 1 104 104 CD cord-029547-9ei1ram3 251 1 Therefore therefore RB cord-029547-9ei1ram3 251 2 , , , cord-029547-9ei1ram3 251 3 stem stem NN cord-029547-9ei1ram3 251 4 cells cell NNS cord-029547-9ei1ram3 251 5 may may MD cord-029547-9ei1ram3 251 6 be be VB cord-029547-9ei1ram3 251 7 the the DT cord-029547-9ei1ram3 251 8 hope hope NN cord-029547-9ei1ram3 251 9 for for IN cord-029547-9ei1ram3 251 10 the the DT cord-029547-9ei1ram3 251 11 treatment treatment NN cord-029547-9ei1ram3 251 12 of of IN cord-029547-9ei1ram3 251 13 severe severe JJ cord-029547-9ei1ram3 251 14 COVID-19 covid-19 JJ cord-029547-9ei1ram3 251 15 patients patient NNS cord-029547-9ei1ram3 251 16 . . . cord-029547-9ei1ram3 252 1 Tens ten NNS cord-029547-9ei1ram3 252 2 of of IN cord-029547-9ei1ram3 252 3 clinical clinical JJ cord-029547-9ei1ram3 252 4 trials trial NNS cord-029547-9ei1ram3 252 5 of of IN cord-029547-9ei1ram3 252 6 stem stem NN cord-029547-9ei1ram3 252 7 cell cell NN cord-029547-9ei1ram3 252 8 treatment treatment NN cord-029547-9ei1ram3 252 9 have have VBP cord-029547-9ei1ram3 252 10 been be VBN cord-029547-9ei1ram3 252 11 registered register VBN cord-029547-9ei1ram3 252 12 in in IN cord-029547-9ei1ram3 252 13 Chinese Chinese NNP cord-029547-9ei1ram3 252 14 Clinical Clinical NNP cord-029547-9ei1ram3 252 15 Trial Trial NNP cord-029547-9ei1ram3 252 16 Registry Registry NNP cord-029547-9ei1ram3 252 17 . . . cord-029547-9ei1ram3 253 1 Recently recently RB cord-029547-9ei1ram3 253 2 , , , cord-029547-9ei1ram3 253 3 many many JJ cord-029547-9ei1ram3 253 4 COVID-19 covid-19 JJ cord-029547-9ei1ram3 253 5 patients patient NNS cord-029547-9ei1ram3 253 6 were be VBD cord-029547-9ei1ram3 253 7 found find VBN cord-029547-9ei1ram3 253 8 to to TO cord-029547-9ei1ram3 253 9 have have VB cord-029547-9ei1ram3 253 10 thrombotic thrombotic JJ cord-029547-9ei1ram3 253 11 risk risk NN cord-029547-9ei1ram3 253 12 , , , cord-029547-9ei1ram3 253 13 105 105 CD cord-029547-9ei1ram3 253 14 therefore therefore RB cord-029547-9ei1ram3 253 15 , , , cord-029547-9ei1ram3 253 16 antithrombotic antithrombotic JJ cord-029547-9ei1ram3 253 17 treatments treatment NNS cord-029547-9ei1ram3 253 18 have have VBP cord-029547-9ei1ram3 253 19 potential potential JJ cord-029547-9ei1ram3 253 20 application application NN cord-029547-9ei1ram3 253 21 value value NN cord-029547-9ei1ram3 253 22 in in IN cord-029547-9ei1ram3 253 23 the the DT cord-029547-9ei1ram3 253 24 treatment treatment NN cord-029547-9ei1ram3 253 25 of of IN cord-029547-9ei1ram3 253 26 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 253 27 . . . cord-029547-9ei1ram3 254 1 Furthermore furthermore RB cord-029547-9ei1ram3 254 2 , , , cord-029547-9ei1ram3 254 3 patients patient NNS cord-029547-9ei1ram3 254 4 with with IN cord-029547-9ei1ram3 254 5 underlying underlie VBG cord-029547-9ei1ram3 254 6 diseases disease NNS cord-029547-9ei1ram3 254 7 such such JJ cord-029547-9ei1ram3 254 8 as as IN cord-029547-9ei1ram3 254 9 hypertension hypertension NN cord-029547-9ei1ram3 254 10 , , , cord-029547-9ei1ram3 254 11 diabetes diabetes NN cord-029547-9ei1ram3 254 12 , , , cord-029547-9ei1ram3 254 13 and and CC cord-029547-9ei1ram3 254 14 cardiovascular cardiovascular JJ cord-029547-9ei1ram3 254 15 disease disease NN cord-029547-9ei1ram3 254 16 have have VBP cord-029547-9ei1ram3 254 17 a a DT cord-029547-9ei1ram3 254 18 potential potential JJ cord-029547-9ei1ram3 254 19 bad bad JJ cord-029547-9ei1ram3 254 20 prognosis prognosis NN cord-029547-9ei1ram3 254 21 , , , cord-029547-9ei1ram3 254 22 106 106 CD cord-029547-9ei1ram3 254 23 - - SYM cord-029547-9ei1ram3 254 24 108 108 CD cord-029547-9ei1ram3 254 25 so so IN cord-029547-9ei1ram3 254 26 care care NN cord-029547-9ei1ram3 254 27 should should MD cord-029547-9ei1ram3 254 28 be be VB cord-029547-9ei1ram3 254 29 taken take VBN cord-029547-9ei1ram3 254 30 to to TO cord-029547-9ei1ram3 254 31 cure cure VB cord-029547-9ei1ram3 254 32 these these DT cord-029547-9ei1ram3 254 33 basic basic JJ cord-029547-9ei1ram3 254 34 diseases disease NNS cord-029547-9ei1ram3 254 35 during during IN cord-029547-9ei1ram3 254 36 treatment treatment NN cord-029547-9ei1ram3 254 37 . . . cord-029547-9ei1ram3 255 1 COVID-19 covid-19 JJ cord-029547-9ei1ram3 255 2 patients patient NNS cord-029547-9ei1ram3 255 3 with with IN cord-029547-9ei1ram3 255 4 low low JJ cord-029547-9ei1ram3 255 5 immunity immunity NN cord-029547-9ei1ram3 255 6 are be VBP cord-029547-9ei1ram3 255 7 susceptible susceptible JJ cord-029547-9ei1ram3 255 8 to to IN cord-029547-9ei1ram3 255 9 hospital hospital NN cord-029547-9ei1ram3 255 10 - - HYPH cord-029547-9ei1ram3 255 11 acquired acquire VBN cord-029547-9ei1ram3 255 12 bacterial bacterial JJ cord-029547-9ei1ram3 255 13 infections infection NNS cord-029547-9ei1ram3 255 14 , , , cord-029547-9ei1ram3 255 15 109 109 CD cord-029547-9ei1ram3 255 16 therefore therefore RB cord-029547-9ei1ram3 255 17 , , , cord-029547-9ei1ram3 255 18 antibiotics antibiotic NNS cord-029547-9ei1ram3 255 19 such such JJ cord-029547-9ei1ram3 255 20 as as IN cord-029547-9ei1ram3 255 21 amoxicillin amoxicillin NNP cord-029547-9ei1ram3 255 22 are be VBP cord-029547-9ei1ram3 255 23 another another DT cord-029547-9ei1ram3 255 24 symptomatic symptomatic JJ cord-029547-9ei1ram3 255 25 treatment treatment NN cord-029547-9ei1ram3 255 26 medicine medicine NN cord-029547-9ei1ram3 255 27 for for IN cord-029547-9ei1ram3 255 28 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 255 29 . . . cord-029547-9ei1ram3 256 1 Traditional traditional JJ cord-029547-9ei1ram3 256 2 Chinese chinese JJ cord-029547-9ei1ram3 256 3 medicine medicine NN cord-029547-9ei1ram3 256 4 has have VBZ cord-029547-9ei1ram3 256 5 been be VBN cord-029547-9ei1ram3 256 6 confirmed confirm VBN cord-029547-9ei1ram3 256 7 to to TO cord-029547-9ei1ram3 256 8 play play VB cord-029547-9ei1ram3 256 9 a a DT cord-029547-9ei1ram3 256 10 vital vital JJ cord-029547-9ei1ram3 256 11 role role NN cord-029547-9ei1ram3 256 12 in in IN cord-029547-9ei1ram3 256 13 treating treat VBG cord-029547-9ei1ram3 256 14 many many JJ cord-029547-9ei1ram3 256 15 respiratory respiratory JJ cord-029547-9ei1ram3 256 16 viruses virus NNS cord-029547-9ei1ram3 256 17 such such JJ cord-029547-9ei1ram3 256 18 as as IN cord-029547-9ei1ram3 257 1 SARS SARS NNP cord-029547-9ei1ram3 257 2 - - HYPH cord-029547-9ei1ram3 257 3 CoV. CoV. NNP cord-029547-9ei1ram3 258 1 Furthermore furthermore RB cord-029547-9ei1ram3 258 2 , , , cord-029547-9ei1ram3 258 3 the the DT cord-029547-9ei1ram3 258 4 General General NNP cord-029547-9ei1ram3 258 5 Office Office NNP cord-029547-9ei1ram3 258 6 of of IN cord-029547-9ei1ram3 258 7 National National NNP cord-029547-9ei1ram3 258 8 Health Health NNP cord-029547-9ei1ram3 258 9 Committee Committee NNP cord-029547-9ei1ram3 258 10 pointed point VBD cord-029547-9ei1ram3 258 11 out out RP cord-029547-9ei1ram3 258 12 that that IN cord-029547-9ei1ram3 258 13 Chinese chinese JJ cord-029547-9ei1ram3 258 14 medicines medicine NNS cord-029547-9ei1ram3 258 15 such such JJ cord-029547-9ei1ram3 258 16 as as IN cord-029547-9ei1ram3 258 17 qingfei qingfei NNP cord-029547-9ei1ram3 258 18 paidu paidu NNP cord-029547-9ei1ram3 258 19 decoction decoction NNP cord-029547-9ei1ram3 258 20 , , , cord-029547-9ei1ram3 258 21 qingfei qingfei NNP cord-029547-9ei1ram3 258 22 touxie touxie NNP cord-029547-9ei1ram3 258 23 fuzheng fuzheng NNP cord-029547-9ei1ram3 258 24 recipe recipe NNP cord-029547-9ei1ram3 258 25 , , , cord-029547-9ei1ram3 258 26 and and CC cord-029547-9ei1ram3 258 27 sheganmahuang sheganmahuang NNP cord-029547-9ei1ram3 258 28 decoction decoction NN cord-029547-9ei1ram3 258 29 could could MD cord-029547-9ei1ram3 258 30 be be VB cord-029547-9ei1ram3 258 31 used use VBN cord-029547-9ei1ram3 258 32 for for IN cord-029547-9ei1ram3 258 33 the the DT cord-029547-9ei1ram3 258 34 whole whole JJ cord-029547-9ei1ram3 258 35 therapeutic therapeutic JJ cord-029547-9ei1ram3 258 36 process process NN cord-029547-9ei1ram3 258 37 of of IN cord-029547-9ei1ram3 258 38 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 258 39 , , , cord-029547-9ei1ram3 258 40 55 55 CD cord-029547-9ei1ram3 258 41 thus thus RB cord-029547-9ei1ram3 258 42 they -PRON- PRP cord-029547-9ei1ram3 258 43 are be VBP cord-029547-9ei1ram3 258 44 widely widely RB cord-029547-9ei1ram3 258 45 used use VBN cord-029547-9ei1ram3 258 46 for for IN cord-029547-9ei1ram3 258 47 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 258 48 treatment treatment NN cord-029547-9ei1ram3 258 49 currently currently RB cord-029547-9ei1ram3 258 50 . . . cord-029547-9ei1ram3 259 1 The the DT cord-029547-9ei1ram3 259 2 present present JJ cord-029547-9ei1ram3 259 3 clinical clinical JJ cord-029547-9ei1ram3 259 4 evidence evidence NN cord-029547-9ei1ram3 259 5 has have VBZ cord-029547-9ei1ram3 259 6 shown show VBN cord-029547-9ei1ram3 259 7 that that IN cord-029547-9ei1ram3 259 8 a a DT cord-029547-9ei1ram3 259 9 combination combination NN cord-029547-9ei1ram3 259 10 of of IN cord-029547-9ei1ram3 259 11 western western JJ cord-029547-9ei1ram3 259 12 and and CC cord-029547-9ei1ram3 259 13 Chinese chinese JJ cord-029547-9ei1ram3 259 14 medicines medicine NNS cord-029547-9ei1ram3 259 15 apparently apparently RB cord-029547-9ei1ram3 259 16 improved improve VBD cord-029547-9ei1ram3 259 17 curative curative JJ cord-029547-9ei1ram3 259 18 effect effect NN cord-029547-9ei1ram3 259 19 . . . cord-029547-9ei1ram3 260 1 110 110 CD cord-029547-9ei1ram3 261 1 For for IN cord-029547-9ei1ram3 261 2 example example NN cord-029547-9ei1ram3 261 3 , , , cord-029547-9ei1ram3 261 4 Wan Wan NNP cord-029547-9ei1ram3 261 5 et et NNP cord-029547-9ei1ram3 261 6 al al NNP cord-029547-9ei1ram3 261 7 . . NNP cord-029547-9ei1ram3 261 8 treated treat VBN cord-029547-9ei1ram3 261 9 124 124 CD cord-029547-9ei1ram3 261 10 patients patient NNS cord-029547-9ei1ram3 261 11 with with IN cord-029547-9ei1ram3 261 12 multiple multiple JJ cord-029547-9ei1ram3 261 13 traditional traditional JJ cord-029547-9ei1ram3 261 14 Chinese chinese JJ cord-029547-9ei1ram3 261 15 medicines medicine NNS cord-029547-9ei1ram3 261 16 such such JJ cord-029547-9ei1ram3 261 17 as as IN cord-029547-9ei1ram3 261 18 Suhuang Suhuang NNP cord-029547-9ei1ram3 261 19 Zhike Zhike NNP cord-029547-9ei1ram3 261 20 capsule capsule NN cord-029547-9ei1ram3 261 21 and and CC cord-029547-9ei1ram3 261 22 Xuebijing Xuebijing NNP cord-029547-9ei1ram3 261 23 , , , cord-029547-9ei1ram3 261 24 and and CC cord-029547-9ei1ram3 261 25 found find VBD cord-029547-9ei1ram3 261 26 their -PRON- PRP$ cord-029547-9ei1ram3 261 27 respiratory respiratory JJ cord-029547-9ei1ram3 261 28 symptoms symptom NNS cord-029547-9ei1ram3 261 29 were be VBD cord-029547-9ei1ram3 261 30 significantly significantly RB cord-029547-9ei1ram3 261 31 improved improve VBN cord-029547-9ei1ram3 261 32 in in IN cord-029547-9ei1ram3 261 33 a a DT cord-029547-9ei1ram3 261 34 shorter short JJR cord-029547-9ei1ram3 261 35 time time NN cord-029547-9ei1ram3 261 36 . . . cord-029547-9ei1ram3 262 1 109 109 CD cord-029547-9ei1ram3 262 2 Furthermore furthermore RB cord-029547-9ei1ram3 262 3 , , , cord-029547-9ei1ram3 262 4 four four CD cord-029547-9ei1ram3 262 5 cases case NNS cord-029547-9ei1ram3 262 6 treated treat VBN cord-029547-9ei1ram3 262 7 with with IN cord-029547-9ei1ram3 262 8 antiviral antiviral JJ cord-029547-9ei1ram3 262 9 drugs drug NNS cord-029547-9ei1ram3 262 10 and and CC cord-029547-9ei1ram3 262 11 Shufeng Shufeng NNP cord-029547-9ei1ram3 262 12 Jiedu Jiedu NNP cord-029547-9ei1ram3 262 13 Capsule Capsule NNP cord-029547-9ei1ram3 262 14 had have VBD cord-029547-9ei1ram3 262 15 an an DT cord-029547-9ei1ram3 262 16 obvious obvious JJ cord-029547-9ei1ram3 262 17 improvement improvement NN cord-029547-9ei1ram3 262 18 both both CC cord-029547-9ei1ram3 262 19 in in IN cord-029547-9ei1ram3 262 20 symptoms symptom NNS cord-029547-9ei1ram3 262 21 and and CC cord-029547-9ei1ram3 262 22 blood blood NN cord-029547-9ei1ram3 262 23 biochemical biochemical JJ cord-029547-9ei1ram3 262 24 indexes index NNS cord-029547-9ei1ram3 262 25 . . . cord-029547-9ei1ram3 263 1 111 111 CD cord-029547-9ei1ram3 264 1 However however RB cord-029547-9ei1ram3 264 2 , , , cord-029547-9ei1ram3 264 3 lack lack NN cord-029547-9ei1ram3 264 4 of of IN cord-029547-9ei1ram3 264 5 a a DT cord-029547-9ei1ram3 264 6 control control NN cord-029547-9ei1ram3 264 7 group group NN cord-029547-9ei1ram3 264 8 means mean VBZ cord-029547-9ei1ram3 264 9 these these DT cord-029547-9ei1ram3 264 10 results result NNS cord-029547-9ei1ram3 264 11 are be VBP cord-029547-9ei1ram3 264 12 not not RB cord-029547-9ei1ram3 264 13 reliable reliable JJ cord-029547-9ei1ram3 264 14 enough enough RB cord-029547-9ei1ram3 264 15 . . . cord-029547-9ei1ram3 265 1 Although although IN cord-029547-9ei1ram3 265 2 treatment treatment NN cord-029547-9ei1ram3 265 3 based base VBN cord-029547-9ei1ram3 265 4 on on IN cord-029547-9ei1ram3 265 5 syndrome syndrome NN cord-029547-9ei1ram3 265 6 differentiation differentiation NN cord-029547-9ei1ram3 265 7 and and CC cord-029547-9ei1ram3 265 8 lack lack NN cord-029547-9ei1ram3 265 9 of of IN cord-029547-9ei1ram3 265 10 scientific scientific JJ cord-029547-9ei1ram3 265 11 evidence evidence NN cord-029547-9ei1ram3 265 12 on on IN cord-029547-9ei1ram3 265 13 mechanisms mechanism NNS cord-029547-9ei1ram3 265 14 are be VBP cord-029547-9ei1ram3 265 15 typical typical JJ cord-029547-9ei1ram3 265 16 characteristics characteristic NNS cord-029547-9ei1ram3 265 17 of of IN cord-029547-9ei1ram3 265 18 traditional traditional JJ cord-029547-9ei1ram3 265 19 Chinese chinese JJ cord-029547-9ei1ram3 265 20 medicines medicine NNS cord-029547-9ei1ram3 265 21 , , , cord-029547-9ei1ram3 265 22 many many JJ cord-029547-9ei1ram3 265 23 of of IN cord-029547-9ei1ram3 265 24 them -PRON- PRP cord-029547-9ei1ram3 265 25 are be VBP cord-029547-9ei1ram3 265 26 gradually gradually RB cord-029547-9ei1ram3 265 27 found find VBN cord-029547-9ei1ram3 265 28 to to TO cord-029547-9ei1ram3 265 29 have have VB cord-029547-9ei1ram3 265 30 antiviral antiviral JJ cord-029547-9ei1ram3 265 31 potential potential NN cord-029547-9ei1ram3 265 32 for for IN cord-029547-9ei1ram3 265 33 SARS SARS NNP cord-029547-9ei1ram3 265 34 - - HYPH cord-029547-9ei1ram3 265 35 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 265 36 . . . cord-029547-9ei1ram3 266 1 Theaflavin Theaflavin NNP cord-029547-9ei1ram3 266 2 is be VBZ cord-029547-9ei1ram3 266 3 conventional conventional JJ cord-029547-9ei1ram3 266 4 ingredient ingredient NN cord-029547-9ei1ram3 266 5 of of IN cord-029547-9ei1ram3 266 6 Chinese chinese JJ cord-029547-9ei1ram3 266 7 medicine medicine NN cord-029547-9ei1ram3 266 8 , , , cord-029547-9ei1ram3 266 9 which which WDT cord-029547-9ei1ram3 266 10 was be VBD cord-029547-9ei1ram3 266 11 found find VBN cord-029547-9ei1ram3 266 12 to to TO cord-029547-9ei1ram3 266 13 have have VB cord-029547-9ei1ram3 266 14 hydrogen hydrogen NN cord-029547-9ei1ram3 266 15 bonds bond NNS cord-029547-9ei1ram3 266 16 to to IN cord-029547-9ei1ram3 266 17 RNA RNA NNP cord-029547-9ei1ram3 266 18 - - HYPH cord-029547-9ei1ram3 266 19 dependent dependent JJ cord-029547-9ei1ram3 266 20 RNA RNA NNP cord-029547-9ei1ram3 266 21 polymerase polymerase NN cord-029547-9ei1ram3 266 22 with with IN cord-029547-9ei1ram3 266 23 a a DT cord-029547-9ei1ram3 266 24 binding bind VBG cord-029547-9ei1ram3 266 25 energy energy NN cord-029547-9ei1ram3 266 26 of of IN cord-029547-9ei1ram3 266 27 −8.8 −8.8 CD cord-029547-9ei1ram3 266 28 kcal kcal NNP cord-029547-9ei1ram3 266 29 / / SYM cord-029547-9ei1ram3 266 30 mol mol NN cord-029547-9ei1ram3 266 31 , , , cord-029547-9ei1ram3 266 32 112 112 CD cord-029547-9ei1ram3 267 1 thus thus RB cord-029547-9ei1ram3 267 2 it -PRON- PRP cord-029547-9ei1ram3 267 3 possibly possibly RB cord-029547-9ei1ram3 267 4 inhibits inhibit VBZ cord-029547-9ei1ram3 267 5 the the DT cord-029547-9ei1ram3 267 6 proliferation proliferation NN cord-029547-9ei1ram3 267 7 of of IN cord-029547-9ei1ram3 267 8 SARS SARS NNP cord-029547-9ei1ram3 267 9 - - HYPH cord-029547-9ei1ram3 267 10 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 267 11 . . . cord-029547-9ei1ram3 268 1 Lianhuaqingwen Lianhuaqingwen NNP cord-029547-9ei1ram3 268 2 was be VBD cord-029547-9ei1ram3 268 3 also also RB cord-029547-9ei1ram3 268 4 confirmed confirm VBN cord-029547-9ei1ram3 268 5 to to TO cord-029547-9ei1ram3 268 6 significantly significantly RB cord-029547-9ei1ram3 268 7 inhibit inhibit VB cord-029547-9ei1ram3 268 8 the the DT cord-029547-9ei1ram3 268 9 replication replication NN cord-029547-9ei1ram3 268 10 of of IN cord-029547-9ei1ram3 268 11 SARS SARS NNP cord-029547-9ei1ram3 268 12 - - HYPH cord-029547-9ei1ram3 268 13 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 268 14 and and CC cord-029547-9ei1ram3 268 15 suppress suppress VB cord-029547-9ei1ram3 268 16 the the DT cord-029547-9ei1ram3 268 17 inflammatory inflammatory JJ cord-029547-9ei1ram3 268 18 factors factor NNS cord-029547-9ei1ram3 268 19 TNF TNF NNP cord-029547-9ei1ram3 268 20 - - HYPH cord-029547-9ei1ram3 268 21 α α NNP cord-029547-9ei1ram3 268 22 , , , cord-029547-9ei1ram3 268 23 IL-6 IL-6 NNP cord-029547-9ei1ram3 268 24 , , , cord-029547-9ei1ram3 268 25 CCL-2 CCL-2 NNP cord-029547-9ei1ram3 268 26 / / SYM cord-029547-9ei1ram3 268 27 MCP-1 MCP-1 NNP cord-029547-9ei1ram3 268 28 , , , cord-029547-9ei1ram3 268 29 and and CC cord-029547-9ei1ram3 268 30 CXCL-10 cxcl-10 NN cord-029547-9ei1ram3 268 31 / / SYM cord-029547-9ei1ram3 268 32 IP-10 IP-10 NNP cord-029547-9ei1ram3 268 33 in in IN cord-029547-9ei1ram3 268 34 Vero Vero NNP cord-029547-9ei1ram3 268 35 E6 E6 NNP cord-029547-9ei1ram3 268 36 cells cell NNS cord-029547-9ei1ram3 268 37 , , , cord-029547-9ei1ram3 268 38 113 113 CD cord-029547-9ei1ram3 269 1 so so CC cord-029547-9ei1ram3 269 2 it -PRON- PRP cord-029547-9ei1ram3 269 3 is be VBZ cord-029547-9ei1ram3 269 4 potentially potentially RB cord-029547-9ei1ram3 269 5 a a DT cord-029547-9ei1ram3 269 6 specific specific JJ cord-029547-9ei1ram3 269 7 medicine medicine NN cord-029547-9ei1ram3 269 8 for for IN cord-029547-9ei1ram3 269 9 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 269 10 both both CC cord-029547-9ei1ram3 269 11 etiologically etiologically RB cord-029547-9ei1ram3 269 12 and and CC cord-029547-9ei1ram3 269 13 symptomatically symptomatically RB cord-029547-9ei1ram3 269 14 . . . cord-029547-9ei1ram3 270 1 The the DT cord-029547-9ei1ram3 270 2 prevention prevention NN cord-029547-9ei1ram3 270 3 and and CC cord-029547-9ei1ram3 270 4 control control NN cord-029547-9ei1ram3 270 5 of of IN cord-029547-9ei1ram3 270 6 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 270 7 can can MD cord-029547-9ei1ram3 270 8 be be VB cord-029547-9ei1ram3 270 9 divided divide VBN cord-029547-9ei1ram3 270 10 into into IN cord-029547-9ei1ram3 270 11 controlling control VBG cord-029547-9ei1ram3 270 12 the the DT cord-029547-9ei1ram3 270 13 source source NN cord-029547-9ei1ram3 270 14 of of IN cord-029547-9ei1ram3 270 15 infection infection NN cord-029547-9ei1ram3 270 16 , , , cord-029547-9ei1ram3 270 17 cutting cut VBG cord-029547-9ei1ram3 270 18 off off RP cord-029547-9ei1ram3 270 19 the the DT cord-029547-9ei1ram3 270 20 transmission transmission NN cord-029547-9ei1ram3 270 21 route route NN cord-029547-9ei1ram3 270 22 , , , cord-029547-9ei1ram3 270 23 and and CC cord-029547-9ei1ram3 270 24 protecting protect VBG cord-029547-9ei1ram3 270 25 susceptible susceptible JJ cord-029547-9ei1ram3 270 26 people people NNS cord-029547-9ei1ram3 270 27 . . . cord-029547-9ei1ram3 271 1 Controlling control VBG cord-029547-9ei1ram3 271 2 the the DT cord-029547-9ei1ram3 271 3 source source NN cord-029547-9ei1ram3 271 4 of of IN cord-029547-9ei1ram3 271 5 infection infection NN cord-029547-9ei1ram3 271 6 in in IN cord-029547-9ei1ram3 271 7 this this DT cord-029547-9ei1ram3 271 8 outbreak outbreak NN cord-029547-9ei1ram3 271 9 mainly mainly RB cord-029547-9ei1ram3 271 10 refers refer VBZ cord-029547-9ei1ram3 271 11 to to IN cord-029547-9ei1ram3 271 12 timely timely JJ cord-029547-9ei1ram3 271 13 isolation isolation NN cord-029547-9ei1ram3 271 14 of of IN cord-029547-9ei1ram3 271 15 suspected suspect VBN cord-029547-9ei1ram3 271 16 and and CC cord-029547-9ei1ram3 271 17 confirmed confirm VBN cord-029547-9ei1ram3 271 18 cases case NNS cord-029547-9ei1ram3 271 19 , , , cord-029547-9ei1ram3 271 20 which which WDT cord-029547-9ei1ram3 271 21 greatly greatly RB cord-029547-9ei1ram3 271 22 depends depend VBZ cord-029547-9ei1ram3 271 23 on on IN cord-029547-9ei1ram3 271 24 wireless wireless JJ cord-029547-9ei1ram3 271 25 communication communication NN cord-029547-9ei1ram3 271 26 data datum NNS cord-029547-9ei1ram3 271 27 . . . cord-029547-9ei1ram3 272 1 114 114 CD cord-029547-9ei1ram3 272 2 Isolation isolation NN cord-029547-9ei1ram3 272 3 of of IN cord-029547-9ei1ram3 272 4 convalescent convalescent JJ cord-029547-9ei1ram3 272 5 patients patient NNS cord-029547-9ei1ram3 272 6 is be VBZ cord-029547-9ei1ram3 272 7 also also RB cord-029547-9ei1ram3 272 8 necessary necessary JJ cord-029547-9ei1ram3 272 9 , , , cord-029547-9ei1ram3 272 10 because because IN cord-029547-9ei1ram3 272 11 some some DT cord-029547-9ei1ram3 272 12 of of IN cord-029547-9ei1ram3 272 13 them -PRON- PRP cord-029547-9ei1ram3 272 14 have have VBP cord-029547-9ei1ram3 272 15 a a DT cord-029547-9ei1ram3 272 16 positive positive JJ cord-029547-9ei1ram3 272 17 RT RT NNP cord-029547-9ei1ram3 272 18 - - HYPH cord-029547-9ei1ram3 272 19 PCR PCR NNP cord-029547-9ei1ram3 272 20 test test NN cord-029547-9ei1ram3 272 21 even even RB cord-029547-9ei1ram3 272 22 after after IN cord-029547-9ei1ram3 272 23 13 13 CD cord-029547-9ei1ram3 272 24 days day NNS cord-029547-9ei1ram3 272 25 of of IN cord-029547-9ei1ram3 272 26 recovery recovery NN cord-029547-9ei1ram3 272 27 . . . cord-029547-9ei1ram3 273 1 115 115 CD cord-029547-9ei1ram3 273 2 Cutting cut VBG cord-029547-9ei1ram3 273 3 off off RP cord-029547-9ei1ram3 273 4 the the DT cord-029547-9ei1ram3 273 5 transmission transmission NN cord-029547-9ei1ram3 273 6 route route NN cord-029547-9ei1ram3 273 7 includes include VBZ cord-029547-9ei1ram3 273 8 sterilizing sterilize VBG cord-029547-9ei1ram3 273 9 and and CC cord-029547-9ei1ram3 273 10 wearing wear VBG cord-029547-9ei1ram3 273 11 suitable suitable JJ cord-029547-9ei1ram3 273 12 masks mask NNS cord-029547-9ei1ram3 273 13 such such JJ cord-029547-9ei1ram3 273 14 as as IN cord-029547-9ei1ram3 273 15 N95 N95 NNP cord-029547-9ei1ram3 273 16 , , , cord-029547-9ei1ram3 273 17 KN95 KN95 NNP cord-029547-9ei1ram3 273 18 , , , cord-029547-9ei1ram3 273 19 and and CC cord-029547-9ei1ram3 273 20 medical medical JJ cord-029547-9ei1ram3 273 21 surgical surgical JJ cord-029547-9ei1ram3 273 22 masks mask NNS cord-029547-9ei1ram3 273 23 . . . cord-029547-9ei1ram3 274 1 116 116 LS cord-029547-9ei1ram3 274 2 Protecting protect VBG cord-029547-9ei1ram3 274 3 susceptible susceptible JJ cord-029547-9ei1ram3 274 4 people people NNS cord-029547-9ei1ram3 274 5 means mean VBZ cord-029547-9ei1ram3 274 6 self self NN cord-029547-9ei1ram3 274 7 - - HYPH cord-029547-9ei1ram3 274 8 segregation segregation NN cord-029547-9ei1ram3 274 9 , , , cord-029547-9ei1ram3 274 10 improving improve VBG cord-029547-9ei1ram3 274 11 constitution constitution NN cord-029547-9ei1ram3 274 12 , , , cord-029547-9ei1ram3 274 13 and and CC cord-029547-9ei1ram3 274 14 prophylactic prophylactic JJ cord-029547-9ei1ram3 274 15 vaccination vaccination NN cord-029547-9ei1ram3 274 16 . . . cord-029547-9ei1ram3 275 1 Considering consider VBG cord-029547-9ei1ram3 275 2 the the DT cord-029547-9ei1ram3 275 3 strong strong JJ cord-029547-9ei1ram3 275 4 infectivity infectivity NN cord-029547-9ei1ram3 275 5 of of IN cord-029547-9ei1ram3 275 6 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 275 7 , , , cord-029547-9ei1ram3 275 8 the the DT cord-029547-9ei1ram3 275 9 secondary secondary JJ cord-029547-9ei1ram3 275 10 outbreak outbreak NN cord-029547-9ei1ram3 275 11 of of IN cord-029547-9ei1ram3 275 12 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 275 13 can can MD cord-029547-9ei1ram3 275 14 be be VB cord-029547-9ei1ram3 275 15 prevented prevent VBN cord-029547-9ei1ram3 275 16 only only RB cord-029547-9ei1ram3 275 17 if if IN cord-029547-9ei1ram3 275 18 the the DT cord-029547-9ei1ram3 275 19 public public NN cord-029547-9ei1ram3 275 20 has have VBZ cord-029547-9ei1ram3 275 21 immunity immunity NN cord-029547-9ei1ram3 275 22 to to IN cord-029547-9ei1ram3 275 23 SARS SARS NNP cord-029547-9ei1ram3 275 24 - - HYPH cord-029547-9ei1ram3 275 25 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 275 26 , , , cord-029547-9ei1ram3 275 27 thus thus RB cord-029547-9ei1ram3 275 28 vaccine vaccine NN cord-029547-9ei1ram3 275 29 is be VBZ cord-029547-9ei1ram3 275 30 the the DT cord-029547-9ei1ram3 275 31 key key JJ cord-029547-9ei1ram3 275 32 area area NN cord-029547-9ei1ram3 275 33 among among IN cord-029547-9ei1ram3 275 34 all all DT cord-029547-9ei1ram3 275 35 prevention prevention NN cord-029547-9ei1ram3 275 36 measures measure NNS cord-029547-9ei1ram3 275 37 . . . cord-029547-9ei1ram3 276 1 Therefore therefore RB cord-029547-9ei1ram3 276 2 , , , cord-029547-9ei1ram3 276 3 scientists scientist NNS cord-029547-9ei1ram3 276 4 all all RB cord-029547-9ei1ram3 276 5 over over IN cord-029547-9ei1ram3 276 6 the the DT cord-029547-9ei1ram3 276 7 world world NN cord-029547-9ei1ram3 276 8 are be VBP cord-029547-9ei1ram3 276 9 working work VBG cord-029547-9ei1ram3 276 10 on on IN cord-029547-9ei1ram3 276 11 the the DT cord-029547-9ei1ram3 276 12 vaccine vaccine NN cord-029547-9ei1ram3 276 13 for for IN cord-029547-9ei1ram3 276 14 SARS SARS NNP cord-029547-9ei1ram3 276 15 - - HYPH cord-029547-9ei1ram3 276 16 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 276 17 , , , cord-029547-9ei1ram3 276 18 aiming aim VBG cord-029547-9ei1ram3 276 19 to to TO cord-029547-9ei1ram3 276 20 completely completely RB cord-029547-9ei1ram3 276 21 control control VB cord-029547-9ei1ram3 276 22 the the DT cord-029547-9ei1ram3 276 23 outbreak outbreak NN cord-029547-9ei1ram3 276 24 . . . cord-029547-9ei1ram3 277 1 After after IN cord-029547-9ei1ram3 277 2 a a DT cord-029547-9ei1ram3 277 3 long long JJ cord-029547-9ei1ram3 277 4 period period NN cord-029547-9ei1ram3 277 5 of of IN cord-029547-9ei1ram3 277 6 effort effort NN cord-029547-9ei1ram3 277 7 , , , cord-029547-9ei1ram3 277 8 the the DT cord-029547-9ei1ram3 277 9 vaccine vaccine NN cord-029547-9ei1ram3 277 10 targets target NNS cord-029547-9ei1ram3 277 11 of of IN cord-029547-9ei1ram3 277 12 the the DT cord-029547-9ei1ram3 277 13 virus virus NN cord-029547-9ei1ram3 277 14 had have VBD cord-029547-9ei1ram3 277 15 been be VBN cord-029547-9ei1ram3 277 16 found find VBN cord-029547-9ei1ram3 277 17 and and CC cord-029547-9ei1ram3 277 18 shared share VBN cord-029547-9ei1ram3 277 19 with with IN cord-029547-9ei1ram3 277 20 the the DT cord-029547-9ei1ram3 277 21 world world NN cord-029547-9ei1ram3 277 22 . . . cord-029547-9ei1ram3 278 1 117 117 CD cord-029547-9ei1ram3 278 2 , , , cord-029547-9ei1ram3 278 3 118 118 CD cord-029547-9ei1ram3 278 4 Soon soon RB cord-029547-9ei1ram3 278 5 afterward afterward RB cord-029547-9ei1ram3 278 6 , , , cord-029547-9ei1ram3 278 7 medical medical JJ cord-029547-9ei1ram3 278 8 institutions institution NNS cord-029547-9ei1ram3 278 9 around around IN cord-029547-9ei1ram3 278 10 the the DT cord-029547-9ei1ram3 278 11 world world NN cord-029547-9ei1ram3 278 12 adapted adapt VBD cord-029547-9ei1ram3 278 13 joint joint JJ cord-029547-9ei1ram3 278 14 research research NN cord-029547-9ei1ram3 278 15 and and CC cord-029547-9ei1ram3 278 16 identified identify VBD cord-029547-9ei1ram3 278 17 five five CD cord-029547-9ei1ram3 278 18 development development NN cord-029547-9ei1ram3 278 19 approaches approach NNS cord-029547-9ei1ram3 278 20 , , , cord-029547-9ei1ram3 278 21 including include VBG cord-029547-9ei1ram3 278 22 a a DT cord-029547-9ei1ram3 278 23 live live JJ cord-029547-9ei1ram3 278 24 attenuated attenuated JJ cord-029547-9ei1ram3 278 25 vaccine vaccine NN cord-029547-9ei1ram3 278 26 , , , cord-029547-9ei1ram3 278 27 inactivated inactivate VBN cord-029547-9ei1ram3 278 28 whole whole JJ cord-029547-9ei1ram3 278 29 - - HYPH cord-029547-9ei1ram3 278 30 virus virus NN cord-029547-9ei1ram3 278 31 vaccine vaccine NN cord-029547-9ei1ram3 278 32 , , , cord-029547-9ei1ram3 278 33 nucleic nucleic JJ cord-029547-9ei1ram3 278 34 acid acid NN cord-029547-9ei1ram3 278 35 vaccine vaccine NN cord-029547-9ei1ram3 278 36 , , , cord-029547-9ei1ram3 278 37 protein protein NN cord-029547-9ei1ram3 278 38 vaccine vaccine NN cord-029547-9ei1ram3 278 39 , , , cord-029547-9ei1ram3 278 40 and and CC cord-029547-9ei1ram3 278 41 viral viral JJ cord-029547-9ei1ram3 278 42 vector vector NN cord-029547-9ei1ram3 278 43 - - HYPH cord-029547-9ei1ram3 278 44 based base VBN cord-029547-9ei1ram3 278 45 vaccine vaccine NN cord-029547-9ei1ram3 278 46 ( ( -LRB- cord-029547-9ei1ram3 278 47 Table Table NNP cord-029547-9ei1ram3 278 48 4 4 CD cord-029547-9ei1ram3 278 49 ) ) -RRB- cord-029547-9ei1ram3 278 50 , , , cord-029547-9ei1ram3 278 51 119 119 CD cord-029547-9ei1ram3 278 52 and and CC cord-029547-9ei1ram3 278 53 most most JJS cord-029547-9ei1ram3 278 54 of of IN cord-029547-9ei1ram3 278 55 them -PRON- PRP cord-029547-9ei1ram3 278 56 used use VBD cord-029547-9ei1ram3 278 57 the the DT cord-029547-9ei1ram3 278 58 S S NNP cord-029547-9ei1ram3 278 59 protein protein NN cord-029547-9ei1ram3 278 60 of of IN cord-029547-9ei1ram3 278 61 SARS SARS NNP cord-029547-9ei1ram3 278 62 - - HYPH cord-029547-9ei1ram3 278 63 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 278 64 as as IN cord-029547-9ei1ram3 278 65 the the DT cord-029547-9ei1ram3 278 66 main main JJ cord-029547-9ei1ram3 278 67 inducer inducer NN cord-029547-9ei1ram3 278 68 of of IN cord-029547-9ei1ram3 278 69 neutralizing neutralize VBG cord-029547-9ei1ram3 278 70 antibodies antibody NNS cord-029547-9ei1ram3 278 71 directly directly RB cord-029547-9ei1ram3 278 72 , , , cord-029547-9ei1ram3 278 73 or or CC cord-029547-9ei1ram3 278 74 inducing induce VBG cord-029547-9ei1ram3 278 75 the the DT cord-029547-9ei1ram3 278 76 expression expression NN cord-029547-9ei1ram3 278 77 of of IN cord-029547-9ei1ram3 278 78 the the DT cord-029547-9ei1ram3 278 79 whole whole JJ cord-029547-9ei1ram3 278 80 S S NNP cord-029547-9ei1ram3 278 81 protein protein NN cord-029547-9ei1ram3 278 82 or or CC cord-029547-9ei1ram3 278 83 receptor receptor NN cord-029547-9ei1ram3 278 84 - - HYPH cord-029547-9ei1ram3 278 85 binding bind VBG cord-029547-9ei1ram3 278 86 domain domain NN cord-029547-9ei1ram3 278 87 of of IN cord-029547-9ei1ram3 278 88 the the DT cord-029547-9ei1ram3 278 89 S S NNP cord-029547-9ei1ram3 278 90 protein protein NN cord-029547-9ei1ram3 278 91 indirectly indirectly RB cord-029547-9ei1ram3 278 92 . . . cord-029547-9ei1ram3 279 1 120 120 CD cord-029547-9ei1ram3 280 1 By by IN cord-029547-9ei1ram3 280 2 interaction interaction NN cord-029547-9ei1ram3 280 3 of of IN cord-029547-9ei1ram3 280 4 the the DT cord-029547-9ei1ram3 280 5 S S NNP cord-029547-9ei1ram3 280 6 protein protein NN cord-029547-9ei1ram3 280 7 and and CC cord-029547-9ei1ram3 280 8 ACE2 ACE2 NNP cord-029547-9ei1ram3 280 9 of of IN cord-029547-9ei1ram3 280 10 host host NN cord-029547-9ei1ram3 280 11 cells cell NNS cord-029547-9ei1ram3 280 12 , , , cord-029547-9ei1ram3 280 13 uncoating uncoating NN cord-029547-9ei1ram3 280 14 and and CC cord-029547-9ei1ram3 280 15 penetration penetration NN cord-029547-9ei1ram3 280 16 of of IN cord-029547-9ei1ram3 280 17 SARS SARS NNP cord-029547-9ei1ram3 280 18 - - HYPH cord-029547-9ei1ram3 280 19 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 280 20 are be VBP cord-029547-9ei1ram3 280 21 induced induce VBN cord-029547-9ei1ram3 280 22 . . . cord-029547-9ei1ram3 281 1 23 23 CD cord-029547-9ei1ram3 282 1 Thus thus RB cord-029547-9ei1ram3 282 2 , , , cord-029547-9ei1ram3 282 3 S s NN cord-029547-9ei1ram3 282 4 - - HYPH cord-029547-9ei1ram3 282 5 protein protein NN cord-029547-9ei1ram3 282 6 - - HYPH cord-029547-9ei1ram3 282 7 based base VBN cord-029547-9ei1ram3 282 8 vaccines vaccine NNS cord-029547-9ei1ram3 282 9 potentially potentially RB cord-029547-9ei1ram3 282 10 inhibit inhibit VBP cord-029547-9ei1ram3 282 11 the the DT cord-029547-9ei1ram3 282 12 uncoating uncoating NN cord-029547-9ei1ram3 282 13 and and CC cord-029547-9ei1ram3 282 14 penetration penetration NN cord-029547-9ei1ram3 282 15 of of IN cord-029547-9ei1ram3 282 16 the the DT cord-029547-9ei1ram3 282 17 virus virus NN cord-029547-9ei1ram3 282 18 . . . cord-029547-9ei1ram3 283 1 Whole whole JJ cord-029547-9ei1ram3 283 2 - - HYPH cord-029547-9ei1ram3 283 3 virus virus NN cord-029547-9ei1ram3 283 4 vaccines vaccine NNS cord-029547-9ei1ram3 283 5 are be VBP cord-029547-9ei1ram3 283 6 conventional conventional JJ cord-029547-9ei1ram3 283 7 strategies strategy NNS cord-029547-9ei1ram3 283 8 to to TO cord-029547-9ei1ram3 283 9 develop develop VB cord-029547-9ei1ram3 283 10 a a DT cord-029547-9ei1ram3 283 11 vaccine vaccine NN cord-029547-9ei1ram3 283 12 for for IN cord-029547-9ei1ram3 283 13 most most JJS cord-029547-9ei1ram3 283 14 viruses virus NNS cord-029547-9ei1ram3 283 15 . . . cord-029547-9ei1ram3 284 1 By by IN cord-029547-9ei1ram3 284 2 injecting inject VBG cord-029547-9ei1ram3 284 3 artificially artificially RB cord-029547-9ei1ram3 284 4 attenuated attenuate VBN cord-029547-9ei1ram3 284 5 or or CC cord-029547-9ei1ram3 284 6 inactivated inactivate VBN cord-029547-9ei1ram3 284 7 viruses virus NNS cord-029547-9ei1ram3 284 8 , , , cord-029547-9ei1ram3 284 9 pathogens pathogen NNS cord-029547-9ei1ram3 284 10 trigger trigger VBP cord-029547-9ei1ram3 284 11 the the DT cord-029547-9ei1ram3 284 12 body body NN cord-029547-9ei1ram3 284 13 's 's POS cord-029547-9ei1ram3 284 14 immune immune JJ cord-029547-9ei1ram3 284 15 response response NN cord-029547-9ei1ram3 284 16 without without IN cord-029547-9ei1ram3 284 17 causing cause VBG cord-029547-9ei1ram3 284 18 disease disease NN cord-029547-9ei1ram3 284 19 . . . cord-029547-9ei1ram3 285 1 Compared compare VBN cord-029547-9ei1ram3 285 2 to to IN cord-029547-9ei1ram3 285 3 other other JJ cord-029547-9ei1ram3 285 4 vaccines vaccine NNS cord-029547-9ei1ram3 285 5 , , , cord-029547-9ei1ram3 285 6 these these DT cord-029547-9ei1ram3 285 7 keep keep VBP cord-029547-9ei1ram3 285 8 the the DT cord-029547-9ei1ram3 285 9 inherent inherent JJ cord-029547-9ei1ram3 285 10 immunogenicity immunogenicity NN cord-029547-9ei1ram3 285 11 of of IN cord-029547-9ei1ram3 285 12 SARS SARS NNP cord-029547-9ei1ram3 285 13 - - HYPH cord-029547-9ei1ram3 285 14 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 285 15 and and CC cord-029547-9ei1ram3 285 16 stimulate stimulate VB cord-029547-9ei1ram3 285 17 the the DT cord-029547-9ei1ram3 285 18 body body NN cord-029547-9ei1ram3 285 19 's 's POS cord-029547-9ei1ram3 285 20 innate innate JJ cord-029547-9ei1ram3 285 21 immunity immunity NN cord-029547-9ei1ram3 285 22 such such JJ cord-029547-9ei1ram3 285 23 as as IN cord-029547-9ei1ram3 285 24 releasing release VBG cord-029547-9ei1ram3 285 25 toll toll NN cord-029547-9ei1ram3 285 26 - - HYPH cord-029547-9ei1ram3 285 27 like like JJ cord-029547-9ei1ram3 285 28 receptors receptor NNS cord-029547-9ei1ram3 285 29 . . . cord-029547-9ei1ram3 286 1 However however RB cord-029547-9ei1ram3 286 2 , , , cord-029547-9ei1ram3 286 3 live live JJ cord-029547-9ei1ram3 286 4 viruses virus NNS cord-029547-9ei1ram3 286 5 have have VBP cord-029547-9ei1ram3 286 6 the the DT cord-029547-9ei1ram3 286 7 potential potential NN cord-029547-9ei1ram3 286 8 to to TO cord-029547-9ei1ram3 286 9 cause cause VB cord-029547-9ei1ram3 286 10 disease disease NN cord-029547-9ei1ram3 286 11 . . . cord-029547-9ei1ram3 287 1 Furthermore furthermore RB cord-029547-9ei1ram3 287 2 , , , cord-029547-9ei1ram3 287 3 it -PRON- PRP cord-029547-9ei1ram3 287 4 has have VBZ cord-029547-9ei1ram3 287 5 been be VBN cord-029547-9ei1ram3 287 6 reported report VBN cord-029547-9ei1ram3 287 7 that that IN cord-029547-9ei1ram3 287 8 patients patient NNS cord-029547-9ei1ram3 287 9 were be VBD cord-029547-9ei1ram3 287 10 more more RBR cord-029547-9ei1ram3 287 11 easily easily RB cord-029547-9ei1ram3 287 12 infected infect VBN cord-029547-9ei1ram3 287 13 by by IN cord-029547-9ei1ram3 287 14 SARS SARS NNP cord-029547-9ei1ram3 287 15 - - HYPH cord-029547-9ei1ram3 287 16 CoV CoV NNP cord-029547-9ei1ram3 287 17 after after IN cord-029547-9ei1ram3 287 18 immunization immunization NN cord-029547-9ei1ram3 287 19 with with IN cord-029547-9ei1ram3 287 20 a a DT cord-029547-9ei1ram3 287 21 live live JJ cord-029547-9ei1ram3 287 22 attenuated attenuated JJ cord-029547-9ei1ram3 287 23 vaccine vaccine NN cord-029547-9ei1ram3 287 24 or or CC cord-029547-9ei1ram3 287 25 inactivated inactivate VBN cord-029547-9ei1ram3 287 26 wholevirus wholevirus NNP cord-029547-9ei1ram3 287 27 vaccine vaccine NN cord-029547-9ei1ram3 287 28 . . . cord-029547-9ei1ram3 288 1 121 121 CD cord-029547-9ei1ram3 289 1 Thus thus RB cord-029547-9ei1ram3 289 2 , , , cord-029547-9ei1ram3 289 3 sufficient sufficient JJ cord-029547-9ei1ram3 289 4 experiments experiment NNS cord-029547-9ei1ram3 289 5 are be VBP cord-029547-9ei1ram3 289 6 necessary necessary JJ cord-029547-9ei1ram3 289 7 to to TO cord-029547-9ei1ram3 289 8 verify verify VB cord-029547-9ei1ram3 289 9 their -PRON- PRP$ cord-029547-9ei1ram3 289 10 safety safety NN cord-029547-9ei1ram3 289 11 . . . cord-029547-9ei1ram3 290 1 Currently currently RB cord-029547-9ei1ram3 290 2 , , , cord-029547-9ei1ram3 290 3 three three CD cord-029547-9ei1ram3 290 4 inactivated inactivate VBN cord-029547-9ei1ram3 290 5 novel novel JJ cord-029547-9ei1ram3 290 6 coronavirus coronavirus NN cord-029547-9ei1ram3 290 7 pneumonia pneumonia NN cord-029547-9ei1ram3 290 8 vaccines vaccine NNS cord-029547-9ei1ram3 290 9 have have VBP cord-029547-9ei1ram3 290 10 entered enter VBN cord-029547-9ei1ram3 290 11 the the DT cord-029547-9ei1ram3 290 12 phase phase NN cord-029547-9ei1ram3 290 13 I -PRON- PRP cord-029547-9ei1ram3 290 14 / / SYM cord-029547-9ei1ram3 290 15 II II NNP cord-029547-9ei1ram3 290 16 clinical clinical JJ cord-029547-9ei1ram3 290 17 trials trial NNS cord-029547-9ei1ram3 290 18 . . . cord-029547-9ei1ram3 291 1 [ [ -LRB- cord-029547-9ei1ram3 291 2 122 122 CD cord-029547-9ei1ram3 291 3 ] ] -RRB- cord-029547-9ei1ram3 291 4 [ [ -LRB- cord-029547-9ei1ram3 291 5 123 123 CD cord-029547-9ei1ram3 291 6 ] ] -RRB- cord-029547-9ei1ram3 292 1 [ [ -LRB- cord-029547-9ei1ram3 292 2 124 124 CD cord-029547-9ei1ram3 292 3 ] ] -RRB- cord-029547-9ei1ram3 292 4 Nucleic nucleic JJ cord-029547-9ei1ram3 292 5 acid acid NN cord-029547-9ei1ram3 292 6 vaccine vaccine NN cord-029547-9ei1ram3 292 7 Nucleic nucleic JJ cord-029547-9ei1ram3 292 8 acid acid NN cord-029547-9ei1ram3 292 9 vaccines vaccine NNS cord-029547-9ei1ram3 292 10 , , , cord-029547-9ei1ram3 292 11 including include VBG cord-029547-9ei1ram3 292 12 DNA dna NN cord-029547-9ei1ram3 292 13 vaccines vaccine NNS cord-029547-9ei1ram3 292 14 and and CC cord-029547-9ei1ram3 292 15 mRNA mrna NN cord-029547-9ei1ram3 292 16 vaccines vaccine NNS cord-029547-9ei1ram3 292 17 , , , cord-029547-9ei1ram3 292 18 are be VBP cord-029547-9ei1ram3 292 19 to to TO cord-029547-9ei1ram3 292 20 directly directly RB cord-029547-9ei1ram3 292 21 deliver deliver VB cord-029547-9ei1ram3 292 22 foreign foreign JJ cord-029547-9ei1ram3 292 23 genes gene NNS cord-029547-9ei1ram3 292 24 encoding encode VBG cord-029547-9ei1ram3 292 25 antigenic antigenic JJ cord-029547-9ei1ram3 292 26 proteins protein NNS cord-029547-9ei1ram3 292 27 into into IN cord-029547-9ei1ram3 292 28 host host NN cord-029547-9ei1ram3 292 29 cells cell NNS cord-029547-9ei1ram3 292 30 and and CC cord-029547-9ei1ram3 292 31 synthesize synthesize VB cord-029547-9ei1ram3 292 32 the the DT cord-029547-9ei1ram3 292 33 antigenic antigenic JJ cord-029547-9ei1ram3 292 34 proteins protein NNS cord-029547-9ei1ram3 292 35 by by IN cord-029547-9ei1ram3 292 36 host host NN cord-029547-9ei1ram3 292 37 cells cell NNS cord-029547-9ei1ram3 292 38 to to TO cord-029547-9ei1ram3 292 39 induce induce VB cord-029547-9ei1ram3 292 40 the the DT cord-029547-9ei1ram3 292 41 immunity immunity NN cord-029547-9ei1ram3 292 42 of of IN cord-029547-9ei1ram3 292 43 hosts host NNS cord-029547-9ei1ram3 292 44 . . . cord-029547-9ei1ram3 293 1 Nucleic nucleic JJ cord-029547-9ei1ram3 293 2 acid acid JJ cord-029547-9ei1ram3 293 3 vaccines vaccine NNS cord-029547-9ei1ram3 293 4 of of IN cord-029547-9ei1ram3 293 5 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 293 6 mainly mainly RB cord-029547-9ei1ram3 293 7 aim aim VBP cord-029547-9ei1ram3 293 8 to to TO cord-029547-9ei1ram3 293 9 induce induce VB cord-029547-9ei1ram3 293 10 the the DT cord-029547-9ei1ram3 293 11 whole whole JJ cord-029547-9ei1ram3 293 12 S S NNP cord-029547-9ei1ram3 293 13 protein protein NN cord-029547-9ei1ram3 293 14 or or CC cord-029547-9ei1ram3 293 15 receptorbinding receptorbinding NN cord-029547-9ei1ram3 293 16 domain domain NN cord-029547-9ei1ram3 293 17 of of IN cord-029547-9ei1ram3 293 18 S S NNP cord-029547-9ei1ram3 293 19 protein protein NN cord-029547-9ei1ram3 293 20 expression expression NN cord-029547-9ei1ram3 293 21 , , , cord-029547-9ei1ram3 293 22 and and CC cord-029547-9ei1ram3 293 23 several several JJ cord-029547-9ei1ram3 293 24 of of IN cord-029547-9ei1ram3 293 25 them -PRON- PRP cord-029547-9ei1ram3 293 26 have have VBP cord-029547-9ei1ram3 293 27 entered enter VBN cord-029547-9ei1ram3 293 28 clinical clinical JJ cord-029547-9ei1ram3 293 29 trials trial NNS cord-029547-9ei1ram3 293 30 . . . cord-029547-9ei1ram3 294 1 125 125 CD cord-029547-9ei1ram3 295 1 For for IN cord-029547-9ei1ram3 295 2 example example NN cord-029547-9ei1ram3 295 3 , , , cord-029547-9ei1ram3 295 4 researchers researcher NNS cord-029547-9ei1ram3 295 5 of of IN cord-029547-9ei1ram3 295 6 Inovio Inovio NNP cord-029547-9ei1ram3 295 7 Pharmaceuticals Pharmaceuticals NNPS cord-029547-9ei1ram3 295 8 are be VBP cord-029547-9ei1ram3 295 9 conducting conduct VBG cord-029547-9ei1ram3 295 10 the the DT cord-029547-9ei1ram3 295 11 clinical clinical JJ cord-029547-9ei1ram3 295 12 trial trial NN cord-029547-9ei1ram3 295 13 of of IN cord-029547-9ei1ram3 295 14 a a DT cord-029547-9ei1ram3 295 15 DNA dna NN cord-029547-9ei1ram3 295 16 vaccine vaccine NN cord-029547-9ei1ram3 295 17 . . . cord-029547-9ei1ram3 296 1 126 126 CD cord-029547-9ei1ram3 297 1 In in IN cord-029547-9ei1ram3 297 2 the the DT cord-029547-9ei1ram3 297 3 meantime meantime NN cord-029547-9ei1ram3 297 4 , , , cord-029547-9ei1ram3 297 5 the the DT cord-029547-9ei1ram3 297 6 National National NNP cord-029547-9ei1ram3 297 7 Institute Institute NNP cord-029547-9ei1ram3 297 8 of of IN cord-029547-9ei1ram3 297 9 Allergy Allergy NNP cord-029547-9ei1ram3 297 10 and and CC cord-029547-9ei1ram3 297 11 Infectious Infectious NNP cord-029547-9ei1ram3 297 12 Diseases Diseases NNPS cord-029547-9ei1ram3 297 13 have have VBP cord-029547-9ei1ram3 297 14 developed develop VBN cord-029547-9ei1ram3 297 15 a a DT cord-029547-9ei1ram3 297 16 mRNA mRNA NNP cord-029547-9ei1ram3 297 17 vaccine vaccine NN cord-029547-9ei1ram3 297 18 , , , cord-029547-9ei1ram3 297 19 mRNA-1273 mrna-1273 XX cord-029547-9ei1ram3 297 20 , , , cord-029547-9ei1ram3 297 21 which which WDT cord-029547-9ei1ram3 297 22 uses use VBZ cord-029547-9ei1ram3 297 23 lipid lipid NN cord-029547-9ei1ram3 297 24 nanoparticles nanoparticle NNS cord-029547-9ei1ram3 297 25 to to TO cord-029547-9ei1ram3 297 26 encapsulate encapsulate VB cord-029547-9ei1ram3 297 27 the the DT cord-029547-9ei1ram3 297 28 mRNA mrna NN cord-029547-9ei1ram3 297 29 encoding encode VBG cord-029547-9ei1ram3 297 30 S S NNP cord-029547-9ei1ram3 297 31 protein protein NN cord-029547-9ei1ram3 297 32 of of IN cord-029547-9ei1ram3 297 33 SARS SARS NNP cord-029547-9ei1ram3 297 34 - - HYPH cord-029547-9ei1ram3 297 35 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 297 36 . . . cord-029547-9ei1ram3 298 1 127 127 CD cord-029547-9ei1ram3 299 1 Interestingly interestingly RB cord-029547-9ei1ram3 299 2 , , , cord-029547-9ei1ram3 299 3 Symvivo Symvivo NNP cord-029547-9ei1ram3 299 4 Corporation Corporation NNP cord-029547-9ei1ram3 299 5 have have VBP cord-029547-9ei1ram3 299 6 developed develop VBN cord-029547-9ei1ram3 299 7 an an DT cord-029547-9ei1ram3 299 8 oral oral JJ cord-029547-9ei1ram3 299 9 DNA dna NN cord-029547-9ei1ram3 299 10 vaccine vaccine NN cord-029547-9ei1ram3 299 11 to to TO cord-029547-9ei1ram3 299 12 avoid avoid VB cord-029547-9ei1ram3 299 13 invasive invasive JJ cord-029547-9ei1ram3 299 14 injection injection NN cord-029547-9ei1ram3 299 15 . . . cord-029547-9ei1ram3 300 1 It -PRON- PRP cord-029547-9ei1ram3 300 2 consists consist VBZ cord-029547-9ei1ram3 300 3 of of IN cord-029547-9ei1ram3 300 4 live live JJ cord-029547-9ei1ram3 300 5 Bifidobacterium Bifidobacterium NNP cord-029547-9ei1ram3 300 6 longum longum NN cord-029547-9ei1ram3 300 7 , , , cord-029547-9ei1ram3 300 8 which which WDT cord-029547-9ei1ram3 300 9 contain contain VBP cord-029547-9ei1ram3 300 10 the the DT cord-029547-9ei1ram3 300 11 synthetic synthetic JJ cord-029547-9ei1ram3 300 12 DNA dna NN cord-029547-9ei1ram3 300 13 encoding encoding NN cord-029547-9ei1ram3 300 14 S s NN cord-029547-9ei1ram3 300 15 protein protein NN cord-029547-9ei1ram3 300 16 . . . cord-029547-9ei1ram3 301 1 128 128 CD cord-029547-9ei1ram3 301 2 _SP cord-029547-9ei1ram3 302 1 Although although IN cord-029547-9ei1ram3 302 2 patients patient NNS cord-029547-9ei1ram3 302 3 with with IN cord-029547-9ei1ram3 302 4 typical typical JJ cord-029547-9ei1ram3 302 5 symptoms symptom NNS cord-029547-9ei1ram3 302 6 are be VBP cord-029547-9ei1ram3 302 7 easily easily RB cord-029547-9ei1ram3 302 8 diagnosed diagnose VBN cord-029547-9ei1ram3 302 9 and and CC cord-029547-9ei1ram3 302 10 isolated isolate VBN cord-029547-9ei1ram3 302 11 , , , cord-029547-9ei1ram3 302 12 we -PRON- PRP cord-029547-9ei1ram3 302 13 still still RB cord-029547-9ei1ram3 302 14 need need VBP cord-029547-9ei1ram3 302 15 to to TO cord-029547-9ei1ram3 302 16 pay pay VB cord-029547-9ei1ram3 302 17 attention attention NN cord-029547-9ei1ram3 302 18 to to IN cord-029547-9ei1ram3 302 19 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 302 20 carriers carrier NNS cord-029547-9ei1ram3 302 21 . . . cord-029547-9ei1ram3 303 1 135 135 CD cord-029547-9ei1ram3 304 1 In in IN cord-029547-9ei1ram3 304 2 January January NNP cord-029547-9ei1ram3 304 3 2020 2020 CD cord-029547-9ei1ram3 304 4 , , , cord-029547-9ei1ram3 304 5 a a DT cord-029547-9ei1ram3 304 6 family family NN cord-029547-9ei1ram3 304 7 cluster cluster NN cord-029547-9ei1ram3 304 8 of of IN cord-029547-9ei1ram3 304 9 three three CD cord-029547-9ei1ram3 304 10 COVID-19 covid-19 CD cord-029547-9ei1ram3 304 11 patients patient NNS cord-029547-9ei1ram3 304 12 with with IN cord-029547-9ei1ram3 304 13 one one CD cord-029547-9ei1ram3 304 14 symptomatic symptomatic JJ cord-029547-9ei1ram3 304 15 and and CC cord-029547-9ei1ram3 304 16 two two CD cord-029547-9ei1ram3 304 17 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 304 18 carriers carrier NNS cord-029547-9ei1ram3 304 19 drew draw VBD cord-029547-9ei1ram3 304 20 great great JJ cord-029547-9ei1ram3 304 21 attention attention NN cord-029547-9ei1ram3 304 22 . . . cord-029547-9ei1ram3 305 1 11 11 CD cord-029547-9ei1ram3 306 1 Because because IN cord-029547-9ei1ram3 306 2 any any DT cord-029547-9ei1ram3 306 3 one one CD cord-029547-9ei1ram3 306 4 of of IN cord-029547-9ei1ram3 306 5 them -PRON- PRP cord-029547-9ei1ram3 306 6 could could MD cord-029547-9ei1ram3 306 7 have have VB cord-029547-9ei1ram3 306 8 the the DT cord-029547-9ei1ram3 306 9 first first JJ cord-029547-9ei1ram3 306 10 one one CD cord-029547-9ei1ram3 306 11 to to TO cord-029547-9ei1ram3 306 12 transmit transmit VB cord-029547-9ei1ram3 306 13 the the DT cord-029547-9ei1ram3 306 14 virus virus NN cord-029547-9ei1ram3 306 15 to to IN cord-029547-9ei1ram3 306 16 others other NNS cord-029547-9ei1ram3 306 17 , , , cord-029547-9ei1ram3 306 18 there there EX cord-029547-9ei1ram3 306 19 may may MD cord-029547-9ei1ram3 306 20 exist exist VB cord-029547-9ei1ram3 306 21 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 306 22 patients patient NNS cord-029547-9ei1ram3 306 23 with with IN cord-029547-9ei1ram3 306 24 high high JJ cord-029547-9ei1ram3 306 25 infectivity infectivity NN cord-029547-9ei1ram3 306 26 who who WP cord-029547-9ei1ram3 306 27 have have VBP cord-029547-9ei1ram3 306 28 not not RB cord-029547-9ei1ram3 306 29 been be VBN cord-029547-9ei1ram3 306 30 detected detect VBN cord-029547-9ei1ram3 306 31 . . . cord-029547-9ei1ram3 307 1 At at IN cord-029547-9ei1ram3 307 2 the the DT cord-029547-9ei1ram3 307 3 same same JJ cord-029547-9ei1ram3 307 4 time time NN cord-029547-9ei1ram3 307 5 , , , cord-029547-9ei1ram3 307 6 another another DT cord-029547-9ei1ram3 307 7 family family NN cord-029547-9ei1ram3 307 8 cluster cluster NN cord-029547-9ei1ram3 307 9 of of IN cord-029547-9ei1ram3 307 10 five five CD cord-029547-9ei1ram3 307 11 patients patient NNS cord-029547-9ei1ram3 307 12 was be VBD cord-029547-9ei1ram3 307 13 found find VBN cord-029547-9ei1ram3 307 14 to to TO cord-029547-9ei1ram3 307 15 have have VB cord-029547-9ei1ram3 307 16 contact contact NN cord-029547-9ei1ram3 307 17 with with IN cord-029547-9ei1ram3 307 18 an an DT cord-029547-9ei1ram3 307 19 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 307 20 carrier carrier NN cord-029547-9ei1ram3 307 21 before before IN cord-029547-9ei1ram3 307 22 onset onset NN cord-029547-9ei1ram3 307 23 of of IN cord-029547-9ei1ram3 307 24 their -PRON- PRP$ cord-029547-9ei1ram3 307 25 symptoms symptom NNS cord-029547-9ei1ram3 307 26 . . . cord-029547-9ei1ram3 308 1 136 136 CD cord-029547-9ei1ram3 309 1 According accord VBG cord-029547-9ei1ram3 309 2 to to IN cord-029547-9ei1ram3 309 3 time time NN cord-029547-9ei1ram3 309 4 sequence sequence NN cord-029547-9ei1ram3 309 5 , , , cord-029547-9ei1ram3 309 6 it -PRON- PRP cord-029547-9ei1ram3 309 7 is be VBZ cord-029547-9ei1ram3 309 8 obvious obvious JJ cord-029547-9ei1ram3 309 9 that that IN cord-029547-9ei1ram3 309 10 the the DT cord-029547-9ei1ram3 309 11 virus virus NN cord-029547-9ei1ram3 309 12 was be VBD cord-029547-9ei1ram3 309 13 transmitted transmit VBN cord-029547-9ei1ram3 309 14 by by IN cord-029547-9ei1ram3 309 15 an an DT cord-029547-9ei1ram3 309 16 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 309 17 carrier carrier NN cord-029547-9ei1ram3 309 18 . . . cord-029547-9ei1ram3 310 1 Hereafter hereafter RB cord-029547-9ei1ram3 310 2 , , , cord-029547-9ei1ram3 310 3 the the DT cord-029547-9ei1ram3 310 4 phenomenon phenomenon NN cord-029547-9ei1ram3 310 5 of of IN cord-029547-9ei1ram3 310 6 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 310 7 infection infection NN cord-029547-9ei1ram3 310 8 has have VBZ cord-029547-9ei1ram3 310 9 been be VBN cord-029547-9ei1ram3 310 10 reported report VBN cord-029547-9ei1ram3 310 11 in in IN cord-029547-9ei1ram3 310 12 several several JJ cord-029547-9ei1ram3 310 13 articles article NNS cord-029547-9ei1ram3 310 14 . . . cord-029547-9ei1ram3 311 1 137 137 CD cord-029547-9ei1ram3 311 2 , , , cord-029547-9ei1ram3 311 3 138 138 CD cord-029547-9ei1ram3 312 1 On on IN cord-029547-9ei1ram3 312 2 the the DT cord-029547-9ei1ram3 312 3 basis basis NN cord-029547-9ei1ram3 312 4 of of IN cord-029547-9ei1ram3 312 5 virology virology NN cord-029547-9ei1ram3 312 6 of of IN cord-029547-9ei1ram3 312 7 SARS SARS NNP cord-029547-9ei1ram3 312 8 - - HYPH cord-029547-9ei1ram3 312 9 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 312 10 , , , cord-029547-9ei1ram3 312 11 quantity quantity NN cord-029547-9ei1ram3 312 12 of of IN cord-029547-9ei1ram3 312 13 shedding shed VBG cord-029547-9ei1ram3 312 14 SARS SARS NNP cord-029547-9ei1ram3 312 15 - - HYPH cord-029547-9ei1ram3 312 16 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 312 17 from from IN cord-029547-9ei1ram3 312 18 pharyngeal pharyngeal JJ cord-029547-9ei1ram3 312 19 sources source NNS cord-029547-9ei1ram3 312 20 is be VBZ cord-029547-9ei1ram3 312 21 very very RB cord-029547-9ei1ram3 312 22 high high JJ cord-029547-9ei1ram3 312 23 in in IN cord-029547-9ei1ram3 312 24 the the DT cord-029547-9ei1ram3 312 25 first first JJ cord-029547-9ei1ram3 312 26 week week NN cord-029547-9ei1ram3 312 27 of of IN cord-029547-9ei1ram3 312 28 symptoms symptom NNS cord-029547-9ei1ram3 312 29 , , , cord-029547-9ei1ram3 312 30 and and CC cord-029547-9ei1ram3 312 31 they -PRON- PRP cord-029547-9ei1ram3 312 32 also also RB cord-029547-9ei1ram3 312 33 replicate replicate VBP cord-029547-9ei1ram3 312 34 actively actively RB cord-029547-9ei1ram3 312 35 during during IN cord-029547-9ei1ram3 312 36 this this DT cord-029547-9ei1ram3 312 37 time time NN cord-029547-9ei1ram3 312 38 , , , cord-029547-9ei1ram3 313 1 thus thus RB cord-029547-9ei1ram3 313 2 the the DT cord-029547-9ei1ram3 313 3 first first JJ cord-029547-9ei1ram3 313 4 week week NN cord-029547-9ei1ram3 313 5 after after IN cord-029547-9ei1ram3 313 6 onset onset NN cord-029547-9ei1ram3 313 7 of of IN cord-029547-9ei1ram3 313 8 symptoms symptom NNS cord-029547-9ei1ram3 313 9 is be VBZ cord-029547-9ei1ram3 313 10 when when WRB cord-029547-9ei1ram3 313 11 the the DT cord-029547-9ei1ram3 313 12 patients patient NNS cord-029547-9ei1ram3 313 13 have have VBP cord-029547-9ei1ram3 313 14 the the DT cord-029547-9ei1ram3 313 15 highest high JJS cord-029547-9ei1ram3 313 16 infectivity infectivity NN cord-029547-9ei1ram3 313 17 . . . cord-029547-9ei1ram3 314 1 139 139 CD cord-029547-9ei1ram3 315 1 But but CC cord-029547-9ei1ram3 315 2 in in IN cord-029547-9ei1ram3 315 3 this this DT cord-029547-9ei1ram3 315 4 time time NN cord-029547-9ei1ram3 315 5 period period NN cord-029547-9ei1ram3 315 6 , , , cord-029547-9ei1ram3 315 7 some some DT cord-029547-9ei1ram3 315 8 patients patient NNS cord-029547-9ei1ram3 315 9 only only RB cord-029547-9ei1ram3 315 10 have have VBP cord-029547-9ei1ram3 315 11 mild mild JJ cord-029547-9ei1ram3 315 12 symptoms symptom NNS cord-029547-9ei1ram3 315 13 or or CC cord-029547-9ei1ram3 315 14 even even RB cord-029547-9ei1ram3 315 15 no no DT cord-029547-9ei1ram3 315 16 symptoms symptom NNS cord-029547-9ei1ram3 315 17 , , , cord-029547-9ei1ram3 315 18 so so IN cord-029547-9ei1ram3 315 19 they -PRON- PRP cord-029547-9ei1ram3 315 20 might may MD cord-029547-9ei1ram3 315 21 be be VB cord-029547-9ei1ram3 315 22 invisible invisible JJ cord-029547-9ei1ram3 315 23 sources source NNS cord-029547-9ei1ram3 315 24 of of IN cord-029547-9ei1ram3 315 25 infection infection NN cord-029547-9ei1ram3 315 26 . . . cord-029547-9ei1ram3 316 1 Therefore therefore RB cord-029547-9ei1ram3 316 2 , , , cord-029547-9ei1ram3 316 3 people people NNS cord-029547-9ei1ram3 316 4 who who WP cord-029547-9ei1ram3 316 5 have have VBP cord-029547-9ei1ram3 316 6 traveled travel VBN cord-029547-9ei1ram3 316 7 to to IN cord-029547-9ei1ram3 316 8 endemic endemic JJ cord-029547-9ei1ram3 316 9 areas area NNS cord-029547-9ei1ram3 316 10 or or CC cord-029547-9ei1ram3 316 11 had have VBD cord-029547-9ei1ram3 316 12 contact contact NN cord-029547-9ei1ram3 316 13 with with IN cord-029547-9ei1ram3 316 14 patients patient NNS cord-029547-9ei1ram3 316 15 should should MD cord-029547-9ei1ram3 316 16 be be VB cord-029547-9ei1ram3 316 17 isolated isolate VBN cord-029547-9ei1ram3 316 18 , , , cord-029547-9ei1ram3 316 19 monitored monitor VBN cord-029547-9ei1ram3 316 20 , , , cord-029547-9ei1ram3 316 21 and and CC cord-029547-9ei1ram3 316 22 screened screen VBN cord-029547-9ei1ram3 316 23 strictly strictly RB cord-029547-9ei1ram3 316 24 , , , cord-029547-9ei1ram3 316 25 even even RB cord-029547-9ei1ram3 316 26 if if IN cord-029547-9ei1ram3 316 27 they -PRON- PRP cord-029547-9ei1ram3 316 28 are be VBP cord-029547-9ei1ram3 316 29 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 316 30 , , , cord-029547-9ei1ram3 316 31 to to TO cord-029547-9ei1ram3 316 32 rule rule VB cord-029547-9ei1ram3 316 33 out out RP cord-029547-9ei1ram3 316 34 the the DT cord-029547-9ei1ram3 316 35 possibility possibility NN cord-029547-9ei1ram3 316 36 of of IN cord-029547-9ei1ram3 316 37 infection infection NN cord-029547-9ei1ram3 316 38 . . . cord-029547-9ei1ram3 317 1 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 317 2 , , , cord-029547-9ei1ram3 317 3 a a DT cord-029547-9ei1ram3 317 4 disease disease NN cord-029547-9ei1ram3 317 5 that that WDT cord-029547-9ei1ram3 317 6 seriously seriously RB cord-029547-9ei1ram3 317 7 endanger endanger VBP cord-029547-9ei1ram3 317 8 the the DT cord-029547-9ei1ram3 317 9 safety safety NN cord-029547-9ei1ram3 317 10 of of IN cord-029547-9ei1ram3 317 11 human human JJ cord-029547-9ei1ram3 317 12 life life NN cord-029547-9ei1ram3 317 13 and and CC cord-029547-9ei1ram3 317 14 properties property NNS cord-029547-9ei1ram3 317 15 , , , cord-029547-9ei1ram3 317 16 is be VBZ cord-029547-9ei1ram3 317 17 caused cause VBN cord-029547-9ei1ram3 317 18 by by IN cord-029547-9ei1ram3 317 19 SARS SARS NNP cord-029547-9ei1ram3 317 20 - - HYPH cord-029547-9ei1ram3 317 21 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 317 22 , , , cord-029547-9ei1ram3 317 23 which which WDT cord-029547-9ei1ram3 317 24 attacks attack VBZ cord-029547-9ei1ram3 317 25 host host NN cord-029547-9ei1ram3 317 26 cells cell NNS cord-029547-9ei1ram3 317 27 through through IN cord-029547-9ei1ram3 317 28 ACE2 ACE2 NNP cord-029547-9ei1ram3 317 29 . . . cord-029547-9ei1ram3 318 1 The the DT cord-029547-9ei1ram3 318 2 spread spread NN cord-029547-9ei1ram3 318 3 of of IN cord-029547-9ei1ram3 318 4 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 318 5 mainly mainly RB cord-029547-9ei1ram3 318 6 depends depend VBZ cord-029547-9ei1ram3 318 7 on on IN cord-029547-9ei1ram3 318 8 airborne airborne JJ cord-029547-9ei1ram3 318 9 and and CC cord-029547-9ei1ram3 318 10 droplet droplet NN cord-029547-9ei1ram3 318 11 transmission transmission NN cord-029547-9ei1ram3 318 12 . . . cord-029547-9ei1ram3 319 1 Some some DT cord-029547-9ei1ram3 319 2 researchers researcher NNS cord-029547-9ei1ram3 319 3 pointed point VBD cord-029547-9ei1ram3 319 4 out out RP cord-029547-9ei1ram3 319 5 the the DT cord-029547-9ei1ram3 319 6 possibility possibility NN cord-029547-9ei1ram3 319 7 of of IN cord-029547-9ei1ram3 319 8 fecal fecal JJ cord-029547-9ei1ram3 319 9 - - HYPH cord-029547-9ei1ram3 319 10 oral oral JJ cord-029547-9ei1ram3 319 11 transmission transmission NN cord-029547-9ei1ram3 319 12 and and CC cord-029547-9ei1ram3 319 13 vertical vertical JJ cord-029547-9ei1ram3 319 14 transmission transmission NN cord-029547-9ei1ram3 319 15 , , , cord-029547-9ei1ram3 319 16 but but CC cord-029547-9ei1ram3 319 17 these these DT cord-029547-9ei1ram3 319 18 opinions opinion NNS cord-029547-9ei1ram3 319 19 need need VBP cord-029547-9ei1ram3 319 20 further further JJ cord-029547-9ei1ram3 319 21 confirmation confirmation NN cord-029547-9ei1ram3 319 22 . . . cord-029547-9ei1ram3 320 1 An an DT cord-029547-9ei1ram3 320 2 accurate accurate JJ cord-029547-9ei1ram3 320 3 diagnosis diagnosis NN cord-029547-9ei1ram3 320 4 of of IN cord-029547-9ei1ram3 320 5 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 320 6 is be VBZ cord-029547-9ei1ram3 320 7 essential essential JJ cord-029547-9ei1ram3 320 8 for for IN cord-029547-9ei1ram3 320 9 containing contain VBG cord-029547-9ei1ram3 320 10 disease disease NN cord-029547-9ei1ram3 320 11 , , , cord-029547-9ei1ram3 320 12 thus thus RB cord-029547-9ei1ram3 320 13 combnation combnation NN cord-029547-9ei1ram3 320 14 of of IN cord-029547-9ei1ram3 320 15 RT RT NNP cord-029547-9ei1ram3 320 16 - - HYPH cord-029547-9ei1ram3 320 17 PCR PCR NNP cord-029547-9ei1ram3 320 18 and and CC cord-029547-9ei1ram3 320 19 clinical clinical JJ cord-029547-9ei1ram3 320 20 characteristics characteristic NNS cord-029547-9ei1ram3 320 21 is be VBZ cord-029547-9ei1ram3 320 22 widely widely RB cord-029547-9ei1ram3 320 23 used use VBN cord-029547-9ei1ram3 320 24 for for IN cord-029547-9ei1ram3 320 25 its -PRON- PRP$ cord-029547-9ei1ram3 320 26 detection detection NN cord-029547-9ei1ram3 320 27 currently currently RB cord-029547-9ei1ram3 320 28 . . . cord-029547-9ei1ram3 321 1 The the DT cord-029547-9ei1ram3 321 2 typical typical JJ cord-029547-9ei1ram3 321 3 clinical clinical JJ cord-029547-9ei1ram3 321 4 features feature NNS cord-029547-9ei1ram3 321 5 of of IN cord-029547-9ei1ram3 321 6 COVID-19 covid-19 JJ cord-029547-9ei1ram3 321 7 patients patient NNS cord-029547-9ei1ram3 321 8 include include VBP cord-029547-9ei1ram3 321 9 fever fever NN cord-029547-9ei1ram3 321 10 , , , cord-029547-9ei1ram3 321 11 cough cough NN cord-029547-9ei1ram3 321 12 , , , cord-029547-9ei1ram3 321 13 and and CC cord-029547-9ei1ram3 321 14 dyspnea dyspnea NN cord-029547-9ei1ram3 321 15 . . . cord-029547-9ei1ram3 322 1 Moreover moreover RB cord-029547-9ei1ram3 322 2 , , , cord-029547-9ei1ram3 322 3 GGO GGO NNP cord-029547-9ei1ram3 322 4 , , , cord-029547-9ei1ram3 322 5 consolidation consolidation NN cord-029547-9ei1ram3 322 6 , , , cord-029547-9ei1ram3 322 7 and and CC cord-029547-9ei1ram3 322 8 interlobular interlobular JJ cord-029547-9ei1ram3 322 9 septal septal JJ cord-029547-9ei1ram3 322 10 thickening thickening NN cord-029547-9ei1ram3 322 11 are be VBP cord-029547-9ei1ram3 322 12 also also RB cord-029547-9ei1ram3 322 13 typical typical JJ cord-029547-9ei1ram3 322 14 CT CT NNP cord-029547-9ei1ram3 322 15 signals signal NNS cord-029547-9ei1ram3 322 16 of of IN cord-029547-9ei1ram3 322 17 COVID-19 covid-19 NN cord-029547-9ei1ram3 322 18 . . . cord-029547-9ei1ram3 323 1 Using use VBG cord-029547-9ei1ram3 323 2 artificial artificial JJ cord-029547-9ei1ram3 323 3 intelligence intelligence NN cord-029547-9ei1ram3 323 4 to to TO cord-029547-9ei1ram3 323 5 screen screen VB cord-029547-9ei1ram3 323 6 COVID-19 covid-19 VB cord-029547-9ei1ram3 323 7 early early RB cord-029547-9ei1ram3 323 8 on on RB cord-029547-9ei1ram3 323 9 is be VBZ cord-029547-9ei1ram3 323 10 likely likely JJ cord-029547-9ei1ram3 323 11 to to TO cord-029547-9ei1ram3 323 12 be be VB cord-029547-9ei1ram3 323 13 the the DT cord-029547-9ei1ram3 323 14 future future JJ cord-029547-9ei1ram3 323 15 diagnostic diagnostic JJ cord-029547-9ei1ram3 323 16 directions direction NNS cord-029547-9ei1ram3 323 17 of of IN cord-029547-9ei1ram3 323 18 it -PRON- PRP cord-029547-9ei1ram3 323 19 . . . cord-029547-9ei1ram3 324 1 Good good JJ cord-029547-9ei1ram3 324 2 treatment treatment NN cord-029547-9ei1ram3 324 3 is be VBZ cord-029547-9ei1ram3 324 4 necessary necessary JJ cord-029547-9ei1ram3 324 5 to to TO cord-029547-9ei1ram3 324 6 reduce reduce VB cord-029547-9ei1ram3 324 7 mortality mortality NN cord-029547-9ei1ram3 324 8 , , , cord-029547-9ei1ram3 324 9 and and CC cord-029547-9ei1ram3 324 10 drug drug NN cord-029547-9ei1ram3 324 11 therapy therapy NN cord-029547-9ei1ram3 324 12 is be VBZ cord-029547-9ei1ram3 324 13 the the DT cord-029547-9ei1ram3 324 14 main main JJ cord-029547-9ei1ram3 324 15 treatment treatment NN cord-029547-9ei1ram3 324 16 of of IN cord-029547-9ei1ram3 324 17 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 324 18 . . . cord-029547-9ei1ram3 325 1 Thus thus RB cord-029547-9ei1ram3 325 2 , , , cord-029547-9ei1ram3 325 3 we -PRON- PRP cord-029547-9ei1ram3 325 4 summarize summarize VBP cord-029547-9ei1ram3 325 5 the the DT cord-029547-9ei1ram3 325 6 chief chief JJ cord-029547-9ei1ram3 325 7 medicines medicine NNS cord-029547-9ei1ram3 325 8 and and CC cord-029547-9ei1ram3 325 9 bioproducts bioproduct NNS cord-029547-9ei1ram3 325 10 for for IN cord-029547-9ei1ram3 325 11 its -PRON- PRP$ cord-029547-9ei1ram3 325 12 treatment treatment NN cord-029547-9ei1ram3 325 13 . . . cord-029547-9ei1ram3 326 1 According accord VBG cord-029547-9ei1ram3 326 2 to to IN cord-029547-9ei1ram3 326 3 the the DT cord-029547-9ei1ram3 326 4 current current JJ cord-029547-9ei1ram3 326 5 reports report NNS cord-029547-9ei1ram3 326 6 , , , cord-029547-9ei1ram3 326 7 combined combine VBN cord-029547-9ei1ram3 326 8 use use NN cord-029547-9ei1ram3 326 9 of of IN cord-029547-9ei1ram3 326 10 the the DT cord-029547-9ei1ram3 326 11 drugs drug NNS cord-029547-9ei1ram3 326 12 and and CC cord-029547-9ei1ram3 326 13 bioproducts bioproduct NNS cord-029547-9ei1ram3 326 14 to to TO cord-029547-9ei1ram3 326 15 treat treat VB cord-029547-9ei1ram3 326 16 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 326 17 both both CC cord-029547-9ei1ram3 326 18 etiologically etiologically RB cord-029547-9ei1ram3 326 19 and and CC cord-029547-9ei1ram3 326 20 symptomatically symptomatically RB cord-029547-9ei1ram3 326 21 has have VBZ cord-029547-9ei1ram3 326 22 received receive VBN cord-029547-9ei1ram3 326 23 great great JJ cord-029547-9ei1ram3 326 24 clinical clinical JJ cord-029547-9ei1ram3 326 25 effect effect NN cord-029547-9ei1ram3 326 26 . . . cord-029547-9ei1ram3 327 1 However however RB cord-029547-9ei1ram3 327 2 , , , cord-029547-9ei1ram3 327 3 not not RB cord-029547-9ei1ram3 327 4 all all DT cord-029547-9ei1ram3 327 5 antiviral antiviral JJ cord-029547-9ei1ram3 327 6 drugs drug NNS cord-029547-9ei1ram3 327 7 for for IN cord-029547-9ei1ram3 327 8 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 327 9 have have VBP cord-029547-9ei1ram3 327 10 passed pass VBN cord-029547-9ei1ram3 327 11 the the DT cord-029547-9ei1ram3 327 12 clinical clinical JJ cord-029547-9ei1ram3 327 13 trials trial NNS cord-029547-9ei1ram3 327 14 . . . cord-029547-9ei1ram3 328 1 A a DT cord-029547-9ei1ram3 328 2 few few JJ cord-029547-9ei1ram3 328 3 clinical clinical JJ cord-029547-9ei1ram3 328 4 trial trial NN cord-029547-9ei1ram3 328 5 reports report NNS cord-029547-9ei1ram3 328 6 demonstrated demonstrate VBD cord-029547-9ei1ram3 328 7 that that IN cord-029547-9ei1ram3 328 8 lopinavir lopinavir NNP cord-029547-9ei1ram3 328 9 - - HYPH cord-029547-9ei1ram3 328 10 ritonavir ritonavir NNP cord-029547-9ei1ram3 328 11 , , , cord-029547-9ei1ram3 328 12 chloroquine chloroquine NN cord-029547-9ei1ram3 328 13 , , , cord-029547-9ei1ram3 328 14 and and CC cord-029547-9ei1ram3 328 15 remdesivir remdesivir NNP cord-029547-9ei1ram3 328 16 did do VBD cord-029547-9ei1ram3 328 17 not not RB cord-029547-9ei1ram3 328 18 work work VB cord-029547-9ei1ram3 328 19 as as RB cord-029547-9ei1ram3 328 20 well well RB cord-029547-9ei1ram3 328 21 as as IN cord-029547-9ei1ram3 328 22 expected expect VBN cord-029547-9ei1ram3 328 23 , , , cord-029547-9ei1ram3 328 24 67 67 CD cord-029547-9ei1ram3 328 25 , , , cord-029547-9ei1ram3 328 26 75 75 CD cord-029547-9ei1ram3 328 27 , , , cord-029547-9ei1ram3 328 28 82 82 CD cord-029547-9ei1ram3 328 29 which which WDT cord-029547-9ei1ram3 328 30 reflects reflect VBZ cord-029547-9ei1ram3 328 31 the the DT cord-029547-9ei1ram3 328 32 fact fact NN cord-029547-9ei1ram3 328 33 that that IN cord-029547-9ei1ram3 328 34 many many JJ cord-029547-9ei1ram3 328 35 antiviral antiviral JJ cord-029547-9ei1ram3 328 36 drugs drug NNS cord-029547-9ei1ram3 328 37 have have VBP cord-029547-9ei1ram3 328 38 gone go VBN cord-029547-9ei1ram3 328 39 through through IN cord-029547-9ei1ram3 328 40 many many JJ cord-029547-9ei1ram3 328 41 extensive extensive JJ cord-029547-9ei1ram3 328 42 clinical clinical JJ cord-029547-9ei1ram3 328 43 trials trial NNS cord-029547-9ei1ram3 328 44 with with IN cord-029547-9ei1ram3 328 45 currently currently RB cord-029547-9ei1ram3 328 46 only only RB cord-029547-9ei1ram3 328 47 modest modest JJ cord-029547-9ei1ram3 328 48 effect effect NN cord-029547-9ei1ram3 328 49 . . . cord-029547-9ei1ram3 329 1 Instead instead RB cord-029547-9ei1ram3 329 2 , , , cord-029547-9ei1ram3 329 3 some some DT cord-029547-9ei1ram3 329 4 bioproducts bioproduct NNS cord-029547-9ei1ram3 329 5 such such JJ cord-029547-9ei1ram3 329 6 as as IN cord-029547-9ei1ram3 329 7 monoclonal monoclonal JJ cord-029547-9ei1ram3 329 8 antibodies antibody NNS cord-029547-9ei1ram3 329 9 and and CC cord-029547-9ei1ram3 329 10 stem stem NN cord-029547-9ei1ram3 329 11 cells cell NNS cord-029547-9ei1ram3 329 12 are be VBP cord-029547-9ei1ram3 329 13 more more RBR cord-029547-9ei1ram3 329 14 likely likely JJ cord-029547-9ei1ram3 329 15 to to TO cord-029547-9ei1ram3 329 16 play play VB cord-029547-9ei1ram3 329 17 important important JJ cord-029547-9ei1ram3 329 18 roles role NNS cord-029547-9ei1ram3 329 19 in in IN cord-029547-9ei1ram3 329 20 treatment treatment NN cord-029547-9ei1ram3 329 21 of of IN cord-029547-9ei1ram3 329 22 severely severely RB cord-029547-9ei1ram3 329 23 affected affect VBN cord-029547-9ei1ram3 329 24 patients patient NNS cord-029547-9ei1ram3 329 25 in in IN cord-029547-9ei1ram3 329 26 the the DT cord-029547-9ei1ram3 329 27 future future NN cord-029547-9ei1ram3 329 28 . . . cord-029547-9ei1ram3 330 1 Furthermore furthermore RB cord-029547-9ei1ram3 330 2 , , , cord-029547-9ei1ram3 330 3 we -PRON- PRP cord-029547-9ei1ram3 330 4 should should MD cord-029547-9ei1ram3 330 5 also also RB cord-029547-9ei1ram3 330 6 focus focus VB cord-029547-9ei1ram3 330 7 on on IN cord-029547-9ei1ram3 330 8 vaccine vaccine NN cord-029547-9ei1ram3 330 9 research research NN cord-029547-9ei1ram3 330 10 and and CC cord-029547-9ei1ram3 330 11 artificial artificial JJ cord-029547-9ei1ram3 330 12 intelligence intelligence NN cord-029547-9ei1ram3 330 13 - - HYPH cord-029547-9ei1ram3 330 14 based base VBN cord-029547-9ei1ram3 330 15 studies study NNS cord-029547-9ei1ram3 330 16 for for IN cord-029547-9ei1ram3 330 17 fighting fight VBG cord-029547-9ei1ram3 330 18 the the DT cord-029547-9ei1ram3 330 19 outbreak outbreak NN cord-029547-9ei1ram3 330 20 , , , cord-029547-9ei1ram3 330 21 both both DT cord-029547-9ei1ram3 330 22 of of IN cord-029547-9ei1ram3 330 23 which which WDT cord-029547-9ei1ram3 330 24 play play VBP cord-029547-9ei1ram3 330 25 vital vital JJ cord-029547-9ei1ram3 330 26 roles role NNS cord-029547-9ei1ram3 330 27 in in IN cord-029547-9ei1ram3 330 28 controlling control VBG cord-029547-9ei1ram3 330 29 the the DT cord-029547-9ei1ram3 330 30 it -PRON- PRP cord-029547-9ei1ram3 330 31 . . . cord-029547-9ei1ram3 331 1 Although although IN cord-029547-9ei1ram3 331 2 antiviral antiviral JJ cord-029547-9ei1ram3 331 3 effects effect NNS cord-029547-9ei1ram3 331 4 of of IN cord-029547-9ei1ram3 331 5 many many JJ cord-029547-9ei1ram3 331 6 drugs drug NNS cord-029547-9ei1ram3 331 7 and and CC cord-029547-9ei1ram3 331 8 vaccines vaccine NNS cord-029547-9ei1ram3 331 9 have have VBP cord-029547-9ei1ram3 331 10 been be VBN cord-029547-9ei1ram3 331 11 obtained obtain VBN cord-029547-9ei1ram3 331 12 in in IN cord-029547-9ei1ram3 331 13 vitro vitro FW cord-029547-9ei1ram3 331 14 , , , cord-029547-9ei1ram3 331 15 it -PRON- PRP cord-029547-9ei1ram3 331 16 remains remain VBZ cord-029547-9ei1ram3 331 17 to to TO cord-029547-9ei1ram3 331 18 be be VB cord-029547-9ei1ram3 331 19 seen see VBN cord-029547-9ei1ram3 331 20 as as IN cord-029547-9ei1ram3 331 21 to to IN cord-029547-9ei1ram3 331 22 whether whether IN cord-029547-9ei1ram3 331 23 they -PRON- PRP cord-029547-9ei1ram3 331 24 have have VBP cord-029547-9ei1ram3 331 25 comparable comparable JJ cord-029547-9ei1ram3 331 26 activity activity NN cord-029547-9ei1ram3 331 27 in in IN cord-029547-9ei1ram3 331 28 vivo vivo NN cord-029547-9ei1ram3 331 29 . . . cord-029547-9ei1ram3 332 1 Therefore therefore RB cord-029547-9ei1ram3 332 2 , , , cord-029547-9ei1ram3 332 3 establishing establish VBG cord-029547-9ei1ram3 332 4 efficient efficient JJ cord-029547-9ei1ram3 332 5 animal animal NN cord-029547-9ei1ram3 332 6 models model NNS cord-029547-9ei1ram3 332 7 as as RB cord-029547-9ei1ram3 332 8 soon soon RB cord-029547-9ei1ram3 332 9 as as IN cord-029547-9ei1ram3 332 10 possible possible JJ cord-029547-9ei1ram3 332 11 is be VBZ cord-029547-9ei1ram3 332 12 important important JJ cord-029547-9ei1ram3 332 13 for for IN cord-029547-9ei1ram3 332 14 virology virology NN cord-029547-9ei1ram3 332 15 research research NN cord-029547-9ei1ram3 332 16 , , , cord-029547-9ei1ram3 332 17 drug drug NN cord-029547-9ei1ram3 332 18 , , , cord-029547-9ei1ram3 332 19 and and CC cord-029547-9ei1ram3 332 20 vaccine vaccine NN cord-029547-9ei1ram3 332 21 development development NN cord-029547-9ei1ram3 332 22 . . . cord-029547-9ei1ram3 333 1 Currently currently RB cord-029547-9ei1ram3 333 2 , , , cord-029547-9ei1ram3 333 3 rhesus rhesu NNS cord-029547-9ei1ram3 333 4 macaques macaque NNS cord-029547-9ei1ram3 333 5 models model NNS cord-029547-9ei1ram3 333 6 have have VBP cord-029547-9ei1ram3 333 7 been be VBN cord-029547-9ei1ram3 333 8 established establish VBN cord-029547-9ei1ram3 333 9 to to TO cord-029547-9ei1ram3 333 10 study study VB cord-029547-9ei1ram3 333 11 the the DT cord-029547-9ei1ram3 333 12 transmission transmission NN cord-029547-9ei1ram3 333 13 and and CC cord-029547-9ei1ram3 333 14 distribution distribution NN cord-029547-9ei1ram3 333 15 of of IN cord-029547-9ei1ram3 333 16 SARS SARS NNP cord-029547-9ei1ram3 333 17 - - HYPH cord-029547-9ei1ram3 333 18 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 333 19 as as RB cord-029547-9ei1ram3 333 20 well well RB cord-029547-9ei1ram3 333 21 as as IN cord-029547-9ei1ram3 333 22 effects effect NNS cord-029547-9ei1ram3 333 23 of of IN cord-029547-9ei1ram3 333 24 viral viral JJ cord-029547-9ei1ram3 333 25 infection infection NN cord-029547-9ei1ram3 333 26 on on IN cord-029547-9ei1ram3 333 27 host host NN cord-029547-9ei1ram3 333 28 prognosis prognosis NN cord-029547-9ei1ram3 333 29 , , , cord-029547-9ei1ram3 333 30 140 140 CD cord-029547-9ei1ram3 333 31 , , , cord-029547-9ei1ram3 333 32 141 141 CD cord-029547-9ei1ram3 333 33 which which WDT cord-029547-9ei1ram3 333 34 is be VBZ cord-029547-9ei1ram3 333 35 meaningful meaningful JJ cord-029547-9ei1ram3 333 36 for for IN cord-029547-9ei1ram3 333 37 virology virology NN cord-029547-9ei1ram3 333 38 study study NN cord-029547-9ei1ram3 333 39 . . . cord-029547-9ei1ram3 334 1 Furthermore furthermore RB cord-029547-9ei1ram3 334 2 , , , cord-029547-9ei1ram3 334 3 hACE2 hace2 NN cord-029547-9ei1ram3 334 4 transgenic transgenic JJ cord-029547-9ei1ram3 334 5 mice mouse NNS cord-029547-9ei1ram3 334 6 have have VBP cord-029547-9ei1ram3 334 7 been be VBN cord-029547-9ei1ram3 334 8 found find VBN cord-029547-9ei1ram3 334 9 to to TO cord-029547-9ei1ram3 334 10 own own VB cord-029547-9ei1ram3 334 11 typical typical JJ cord-029547-9ei1ram3 334 12 COVID-19 covid-19 JJ cord-029547-9ei1ram3 334 13 clinical clinical JJ cord-029547-9ei1ram3 334 14 symptoms symptom NNS cord-029547-9ei1ram3 334 15 , , , cord-029547-9ei1ram3 334 16 which which WDT cord-029547-9ei1ram3 334 17 could could MD cord-029547-9ei1ram3 334 18 not not RB cord-029547-9ei1ram3 334 19 be be VB cord-029547-9ei1ram3 334 20 found find VBN cord-029547-9ei1ram3 334 21 in in IN cord-029547-9ei1ram3 334 22 wild wild JJ cord-029547-9ei1ram3 334 23 - - HYPH cord-029547-9ei1ram3 334 24 type type NN cord-029547-9ei1ram3 334 25 mice mouse NNS cord-029547-9ei1ram3 334 26 , , , cord-029547-9ei1ram3 334 27 142 142 CD cord-029547-9ei1ram3 334 28 indicating indicate VBG cord-029547-9ei1ram3 334 29 this this DT cord-029547-9ei1ram3 334 30 model model NN cord-029547-9ei1ram3 334 31 may may MD cord-029547-9ei1ram3 334 32 be be VB cord-029547-9ei1ram3 334 33 used use VBN cord-029547-9ei1ram3 334 34 for for IN cord-029547-9ei1ram3 334 35 development development NN cord-029547-9ei1ram3 334 36 of of IN cord-029547-9ei1ram3 334 37 therapeutic therapeutic JJ cord-029547-9ei1ram3 334 38 drugs drug NNS cord-029547-9ei1ram3 334 39 and and CC cord-029547-9ei1ram3 334 40 vaccines vaccine NNS cord-029547-9ei1ram3 334 41 . . . cord-029547-9ei1ram3 335 1 Thus thus RB cord-029547-9ei1ram3 335 2 , , , cord-029547-9ei1ram3 335 3 perhaps perhaps RB cord-029547-9ei1ram3 335 4 further further RB cord-029547-9ei1ram3 335 5 researching research VBG cord-029547-9ei1ram3 335 6 effective effective JJ cord-029547-9ei1ram3 335 7 animal animal NN cord-029547-9ei1ram3 335 8 models model NNS cord-029547-9ei1ram3 335 9 and and CC cord-029547-9ei1ram3 335 10 making make VBG cord-029547-9ei1ram3 335 11 full full JJ cord-029547-9ei1ram3 335 12 use use NN cord-029547-9ei1ram3 335 13 of of IN cord-029547-9ei1ram3 335 14 them -PRON- PRP cord-029547-9ei1ram3 335 15 shows show VBZ cord-029547-9ei1ram3 335 16 the the DT cord-029547-9ei1ram3 335 17 future future JJ cord-029547-9ei1ram3 335 18 direction direction NN cord-029547-9ei1ram3 335 19 to to TO cord-029547-9ei1ram3 335 20 develop develop VB cord-029547-9ei1ram3 335 21 drugs drug NNS cord-029547-9ei1ram3 335 22 and and CC cord-029547-9ei1ram3 335 23 vaccines vaccine NNS cord-029547-9ei1ram3 335 24 with with IN cord-029547-9ei1ram3 335 25 high high JJ cord-029547-9ei1ram3 335 26 specificity specificity NN cord-029547-9ei1ram3 335 27 as as RB cord-029547-9ei1ram3 335 28 soon soon RB cord-029547-9ei1ram3 335 29 as as IN cord-029547-9ei1ram3 335 30 possible possible JJ cord-029547-9ei1ram3 335 31 . . . cord-029547-9ei1ram3 336 1 J.L. J.L. NNP cord-029547-9ei1ram3 336 2 , , , cord-029547-9ei1ram3 336 3 J.S. J.S. NNP cord-029547-9ei1ram3 336 4 , , , cord-029547-9ei1ram3 336 5 and and CC cord-029547-9ei1ram3 336 6 C.W. C.W. NNP cord-029547-9ei1ram3 336 7 wrote write VBD cord-029547-9ei1ram3 336 8 the the DT cord-029547-9ei1ram3 336 9 initial initial JJ cord-029547-9ei1ram3 336 10 draft draft NN cord-029547-9ei1ram3 336 11 of of IN cord-029547-9ei1ram3 336 12 the the DT cord-029547-9ei1ram3 336 13 manuscript manuscript NN cord-029547-9ei1ram3 336 14 . . . cord-029547-9ei1ram3 337 1 J.L. J.L. NNP cord-029547-9ei1ram3 337 2 and and CC cord-029547-9ei1ram3 337 3 C.W. C.W. NNP cord-029547-9ei1ram3 337 4 gathered gather VBD cord-029547-9ei1ram3 337 5 important important JJ cord-029547-9ei1ram3 337 6 information information NN cord-029547-9ei1ram3 337 7 . . . cord-029547-9ei1ram3 338 1 C.W. C.W. NNP cord-029547-9ei1ram3 338 2 and and CC cord-029547-9ei1ram3 338 3 W.L. W.L. NNP cord-029547-9ei1ram3 338 4 provided provide VBD cord-029547-9ei1ram3 338 5 critical critical JJ cord-029547-9ei1ram3 338 6 revision revision NN cord-029547-9ei1ram3 338 7 of of IN cord-029547-9ei1ram3 338 8 the the DT cord-029547-9ei1ram3 338 9 manuscript manuscript NN cord-029547-9ei1ram3 338 10 . . . cord-029547-9ei1ram3 339 1 Early early JJ cord-029547-9ei1ram3 339 2 transmission transmission NN cord-029547-9ei1ram3 339 3 dynamics dynamic NNS cord-029547-9ei1ram3 339 4 in in IN cord-029547-9ei1ram3 339 5 Wuhan Wuhan NNP cord-029547-9ei1ram3 339 6 , , , cord-029547-9ei1ram3 339 7 China China NNP cord-029547-9ei1ram3 339 8 , , , cord-029547-9ei1ram3 339 9 of of IN cord-029547-9ei1ram3 339 10 novel novel JJ cord-029547-9ei1ram3 339 11 coronavirus coronavirus NN cord-029547-9ei1ram3 339 12 - - HYPH cord-029547-9ei1ram3 339 13 infected infect VBN cord-029547-9ei1ram3 339 14 pneumonia pneumonia NN cord-029547-9ei1ram3 340 1 A a DT cord-029547-9ei1ram3 340 2 novel novel JJ cord-029547-9ei1ram3 340 3 coronavirus coronavirus NN cord-029547-9ei1ram3 340 4 from from IN cord-029547-9ei1ram3 340 5 patients patient NNS cord-029547-9ei1ram3 340 6 with with IN cord-029547-9ei1ram3 340 7 pneumonia pneumonia NN cord-029547-9ei1ram3 340 8 in in IN cord-029547-9ei1ram3 340 9 China China NNP cord-029547-9ei1ram3 340 10 Case case NN cord-029547-9ei1ram3 340 11 - - HYPH cord-029547-9ei1ram3 340 12 fatality fatality NN cord-029547-9ei1ram3 340 13 rate rate NN cord-029547-9ei1ram3 340 14 and and CC cord-029547-9ei1ram3 340 15 characteristics characteristic NNS cord-029547-9ei1ram3 340 16 of of IN cord-029547-9ei1ram3 340 17 patients patient NNS cord-029547-9ei1ram3 340 18 dying die VBG cord-029547-9ei1ram3 340 19 in in IN cord-029547-9ei1ram3 340 20 relation relation NN cord-029547-9ei1ram3 340 21 to to IN cord-029547-9ei1ram3 340 22 COVID-19 covid-19 VB cord-029547-9ei1ram3 340 23 in in IN cord-029547-9ei1ram3 340 24 Italy Italy NNP cord-029547-9ei1ram3 340 25 Community Community NNP cord-029547-9ei1ram3 340 26 prevalence prevalence NN cord-029547-9ei1ram3 340 27 of of IN cord-029547-9ei1ram3 340 28 SARS SARS NNP cord-029547-9ei1ram3 340 29 - - HYPH cord-029547-9ei1ram3 340 30 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 340 31 among among IN cord-029547-9ei1ram3 340 32 patients patient NNS cord-029547-9ei1ram3 340 33 with with IN cord-029547-9ei1ram3 340 34 influenzalike influenzalike JJ cord-029547-9ei1ram3 340 35 illnesses illness NNS cord-029547-9ei1ram3 340 36 presenting present VBG cord-029547-9ei1ram3 340 37 to to IN cord-029547-9ei1ram3 340 38 a a DT cord-029547-9ei1ram3 340 39 Los Los NNP cord-029547-9ei1ram3 340 40 Angeles Angeles NNP cord-029547-9ei1ram3 340 41 Medical Medical NNP cord-029547-9ei1ram3 340 42 Center Center NNP cord-029547-9ei1ram3 340 43 Importation Importation NNP cord-029547-9ei1ram3 340 44 and and CC cord-029547-9ei1ram3 340 45 human human NN cord-029547-9ei1ram3 340 46 - - HYPH cord-029547-9ei1ram3 340 47 to to IN cord-029547-9ei1ram3 340 48 - - HYPH cord-029547-9ei1ram3 340 49 human human JJ cord-029547-9ei1ram3 340 50 transmission transmission NN cord-029547-9ei1ram3 340 51 of of IN cord-029547-9ei1ram3 340 52 a a DT cord-029547-9ei1ram3 340 53 novel novel JJ cord-029547-9ei1ram3 340 54 coronavirus coronavirus NN cord-029547-9ei1ram3 340 55 in in IN cord-029547-9ei1ram3 340 56 Vietnam Vietnam NNP cord-029547-9ei1ram3 340 57 Epidemiology Epidemiology NNP cord-029547-9ei1ram3 340 58 of of IN cord-029547-9ei1ram3 340 59 Covid-19 covid-19 NN cord-029547-9ei1ram3 340 60 in in IN cord-029547-9ei1ram3 340 61 a a DT cord-029547-9ei1ram3 340 62 long long JJ cord-029547-9ei1ram3 340 63 - - HYPH cord-029547-9ei1ram3 340 64 term term NN cord-029547-9ei1ram3 340 65 care care NN cord-029547-9ei1ram3 340 66 facility facility NN cord-029547-9ei1ram3 340 67 in in IN cord-029547-9ei1ram3 340 68 King King NNP cord-029547-9ei1ram3 340 69 County County NNP cord-029547-9ei1ram3 340 70 , , , cord-029547-9ei1ram3 340 71 Washington Washington NNP cord-029547-9ei1ram3 341 1 The the DT cord-029547-9ei1ram3 341 2 author author NN cord-029547-9ei1ram3 341 3 's 's POS cord-029547-9ei1ram3 341 4 response response NN cord-029547-9ei1ram3 341 5 : : : cord-029547-9ei1ram3 341 6 case case NN cord-029547-9ei1ram3 341 7 of of IN cord-029547-9ei1ram3 341 8 the the DT cord-029547-9ei1ram3 341 9 index index NN cord-029547-9ei1ram3 341 10 patient patient NN cord-029547-9ei1ram3 341 11 who who WP cord-029547-9ei1ram3 341 12 caused cause VBD cord-029547-9ei1ram3 341 13 tertiary tertiary JJ cord-029547-9ei1ram3 341 14 transmission transmission NN cord-029547-9ei1ram3 341 15 of of IN cord-029547-9ei1ram3 341 16 coronavirus coronavirus NN cord-029547-9ei1ram3 341 17 disease disease NN cord-029547-9ei1ram3 341 18 2019 2019 CD cord-029547-9ei1ram3 341 19 in in IN cord-029547-9ei1ram3 341 20 Korea Korea NNP cord-029547-9ei1ram3 341 21 : : : cord-029547-9ei1ram3 341 22 the the DT cord-029547-9ei1ram3 341 23 application application NN cord-029547-9ei1ram3 341 24 of of IN cord-029547-9ei1ram3 341 25 Lopinavir Lopinavir NNP cord-029547-9ei1ram3 341 26 / / SYM cord-029547-9ei1ram3 341 27 Ritonavir Ritonavir NNP cord-029547-9ei1ram3 341 28 for for IN cord-029547-9ei1ram3 341 29 the the DT cord-029547-9ei1ram3 341 30 treatment treatment NN cord-029547-9ei1ram3 341 31 of of IN cord-029547-9ei1ram3 341 32 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 341 33 pneumonia pneumonia NN cord-029547-9ei1ram3 341 34 monitored monitor VBN cord-029547-9ei1ram3 341 35 by by IN cord-029547-9ei1ram3 341 36 quantitative quantitative JJ cord-029547-9ei1ram3 341 37 RT RT NNP cord-029547-9ei1ram3 341 38 - - HYPH cord-029547-9ei1ram3 341 39 PCR PCR NNP cord-029547-9ei1ram3 341 40 Combination Combination NNP cord-029547-9ei1ram3 341 41 of of IN cord-029547-9ei1ram3 341 42 RT RT NNP cord-029547-9ei1ram3 341 43 - - HYPH cord-029547-9ei1ram3 341 44 qPCR qpcr NN cord-029547-9ei1ram3 341 45 testing testing NN cord-029547-9ei1ram3 341 46 and and CC cord-029547-9ei1ram3 341 47 clinical clinical JJ cord-029547-9ei1ram3 341 48 features feature NNS cord-029547-9ei1ram3 341 49 for for IN cord-029547-9ei1ram3 341 50 diagnosis diagnosis NN cord-029547-9ei1ram3 341 51 of of IN cord-029547-9ei1ram3 341 52 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 341 53 facilitates facilitate VBZ cord-029547-9ei1ram3 341 54 management management NN cord-029547-9ei1ram3 341 55 of of IN cord-029547-9ei1ram3 341 56 SARS SARS NNP cord-029547-9ei1ram3 341 57 - - HYPH cord-029547-9ei1ram3 341 58 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 341 59 outbreak outbreak NN cord-029547-9ei1ram3 341 60 Planning planning NN cord-029547-9ei1ram3 341 61 and and CC cord-029547-9ei1ram3 341 62 provision provision NN cord-029547-9ei1ram3 341 63 of of IN cord-029547-9ei1ram3 341 64 ECMO ECMO NNP cord-029547-9ei1ram3 341 65 services service NNS cord-029547-9ei1ram3 341 66 for for IN cord-029547-9ei1ram3 341 67 severe severe JJ cord-029547-9ei1ram3 341 68 ARDS ARDS NNP cord-029547-9ei1ram3 341 69 during during IN cord-029547-9ei1ram3 341 70 the the DT cord-029547-9ei1ram3 341 71 COVID-19 covid-19 JJ cord-029547-9ei1ram3 341 72 pandemic pandemic NN cord-029547-9ei1ram3 341 73 and and CC cord-029547-9ei1ram3 341 74 other other JJ cord-029547-9ei1ram3 341 75 outbreaks outbreak NNS cord-029547-9ei1ram3 341 76 of of IN cord-029547-9ei1ram3 341 77 emerging emerge VBG cord-029547-9ei1ram3 341 78 infectious infectious JJ cord-029547-9ei1ram3 341 79 diseases disease NNS cord-029547-9ei1ram3 341 80 Treatment treatment NN cord-029547-9ei1ram3 341 81 for for IN cord-029547-9ei1ram3 341 82 severe severe JJ cord-029547-9ei1ram3 341 83 acute acute JJ cord-029547-9ei1ram3 341 84 respiratory respiratory JJ cord-029547-9ei1ram3 341 85 distress distress NN cord-029547-9ei1ram3 341 86 syndrome syndrome NN cord-029547-9ei1ram3 341 87 from from IN cord-029547-9ei1ram3 341 88 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 341 89 Asymptomatic asymptomatic JJ cord-029547-9ei1ram3 341 90 cases case NNS cord-029547-9ei1ram3 341 91 in in IN cord-029547-9ei1ram3 341 92 a a DT cord-029547-9ei1ram3 341 93 family family NN cord-029547-9ei1ram3 341 94 cluster cluster NN cord-029547-9ei1ram3 341 95 with with IN cord-029547-9ei1ram3 341 96 SARS SARS NNP cord-029547-9ei1ram3 341 97 - - HYPH cord-029547-9ei1ram3 341 98 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 341 99 infection infection NN cord-029547-9ei1ram3 341 100 Coronaviridae Coronaviridae NNP cord-029547-9ei1ram3 341 101 Study Study NNP cord-029547-9ei1ram3 341 102 Group Group NNP cord-029547-9ei1ram3 341 103 of of IN cord-029547-9ei1ram3 341 104 the the DT cord-029547-9ei1ram3 341 105 International International NNP cord-029547-9ei1ram3 341 106 Committee Committee NNP cord-029547-9ei1ram3 341 107 on on IN cord-029547-9ei1ram3 341 108 Taxonomy Taxonomy NNP cord-029547-9ei1ram3 341 109 of of IN cord-029547-9ei1ram3 341 110 Viruses Viruses NNPS cord-029547-9ei1ram3 341 111 . . . cord-029547-9ei1ram3 342 1 The the DT cord-029547-9ei1ram3 342 2 species specie NNS cord-029547-9ei1ram3 342 3 severe severe JJ cord-029547-9ei1ram3 342 4 acute acute JJ cord-029547-9ei1ram3 342 5 respiratory respiratory JJ cord-029547-9ei1ram3 342 6 syndrome syndrome NN cord-029547-9ei1ram3 342 7 - - HYPH cord-029547-9ei1ram3 342 8 related relate VBN cord-029547-9ei1ram3 342 9 coronavirus coronavirus NN cord-029547-9ei1ram3 342 10 : : : cord-029547-9ei1ram3 342 11 classifying classify VBG cord-029547-9ei1ram3 342 12 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 342 13 and and CC cord-029547-9ei1ram3 342 14 naming name VBG cord-029547-9ei1ram3 342 15 it -PRON- PRP cord-029547-9ei1ram3 342 16 SARS SARS NNP cord-029547-9ei1ram3 342 17 - - HYPH cord-029547-9ei1ram3 342 18 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 343 1 A a DT cord-029547-9ei1ram3 343 2 pneumonia pneumonia NN cord-029547-9ei1ram3 343 3 outbreak outbreak NN cord-029547-9ei1ram3 343 4 associated associate VBN cord-029547-9ei1ram3 343 5 with with IN cord-029547-9ei1ram3 343 6 a a DT cord-029547-9ei1ram3 343 7 new new JJ cord-029547-9ei1ram3 343 8 coronavirus coronavirus NN cord-029547-9ei1ram3 343 9 of of IN cord-029547-9ei1ram3 343 10 probable probable JJ cord-029547-9ei1ram3 343 11 bat bat NN cord-029547-9ei1ram3 343 12 origin origin NN cord-029547-9ei1ram3 344 1 A a DT cord-029547-9ei1ram3 344 2 new new JJ cord-029547-9ei1ram3 344 3 coronavirus coronavirus NN cord-029547-9ei1ram3 344 4 associated associate VBN cord-029547-9ei1ram3 344 5 with with IN cord-029547-9ei1ram3 344 6 human human JJ cord-029547-9ei1ram3 344 7 respiratory respiratory JJ cord-029547-9ei1ram3 344 8 disease disease NN cord-029547-9ei1ram3 344 9 in in IN cord-029547-9ei1ram3 344 10 China China NNP cord-029547-9ei1ram3 344 11 A a DT cord-029547-9ei1ram3 344 12 genomic genomic JJ cord-029547-9ei1ram3 344 13 perspective perspective NN cord-029547-9ei1ram3 344 14 on on IN cord-029547-9ei1ram3 344 15 the the DT cord-029547-9ei1ram3 344 16 origin origin NN cord-029547-9ei1ram3 344 17 and and CC cord-029547-9ei1ram3 344 18 emergence emergence NN cord-029547-9ei1ram3 344 19 of of IN cord-029547-9ei1ram3 344 20 SARS SARS NNP cord-029547-9ei1ram3 344 21 - - HYPH cord-029547-9ei1ram3 344 22 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 344 23 Genomic genomic JJ cord-029547-9ei1ram3 344 24 characterisation characterisation NN cord-029547-9ei1ram3 344 25 and and CC cord-029547-9ei1ram3 344 26 epidemiology epidemiology NN cord-029547-9ei1ram3 344 27 of of IN cord-029547-9ei1ram3 344 28 2019 2019 CD cord-029547-9ei1ram3 344 29 novel novel JJ cord-029547-9ei1ram3 344 30 coronavirus coronavirus NN cord-029547-9ei1ram3 344 31 : : : cord-029547-9ei1ram3 344 32 implications implication NNS cord-029547-9ei1ram3 344 33 for for IN cord-029547-9ei1ram3 344 34 virus virus NN cord-029547-9ei1ram3 344 35 origins origin NNS cord-029547-9ei1ram3 344 36 and and CC cord-029547-9ei1ram3 344 37 receptor receptor NN cord-029547-9ei1ram3 344 38 binding bind VBG cord-029547-9ei1ram3 344 39 Cross Cross NNP cord-029547-9ei1ram3 344 40 - - HYPH cord-029547-9ei1ram3 344 41 species species JJ cord-029547-9ei1ram3 344 42 transmission transmission NN cord-029547-9ei1ram3 344 43 of of IN cord-029547-9ei1ram3 344 44 the the DT cord-029547-9ei1ram3 344 45 newly newly RB cord-029547-9ei1ram3 344 46 identified identify VBN cord-029547-9ei1ram3 344 47 coronavirus coronavirus NN cord-029547-9ei1ram3 345 1 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 346 1 The the DT cord-029547-9ei1ram3 346 2 origin origin NN cord-029547-9ei1ram3 346 3 and and CC cord-029547-9ei1ram3 346 4 underlying underlying JJ cord-029547-9ei1ram3 346 5 driving drive VBG cord-029547-9ei1ram3 346 6 forces force NNS cord-029547-9ei1ram3 346 7 of of IN cord-029547-9ei1ram3 346 8 the the DT cord-029547-9ei1ram3 346 9 SARS SARS NNP cord-029547-9ei1ram3 346 10 - - HYPH cord-029547-9ei1ram3 346 11 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 346 12 outbreak outbreak NN cord-029547-9ei1ram3 346 13 Composition composition NN cord-029547-9ei1ram3 346 14 and and CC cord-029547-9ei1ram3 346 15 divergence divergence NN cord-029547-9ei1ram3 346 16 of of IN cord-029547-9ei1ram3 346 17 coronavirus coronavirus NN cord-029547-9ei1ram3 346 18 spike spike NN cord-029547-9ei1ram3 346 19 proteins protein NNS cord-029547-9ei1ram3 346 20 and and CC cord-029547-9ei1ram3 346 21 host host NN cord-029547-9ei1ram3 346 22 ACE2 ACE2 NNP cord-029547-9ei1ram3 346 23 receptors receptor NNS cord-029547-9ei1ram3 346 24 predict predict VBP cord-029547-9ei1ram3 346 25 potential potential JJ cord-029547-9ei1ram3 346 26 intermediate intermediate JJ cord-029547-9ei1ram3 346 27 hosts host NNS cord-029547-9ei1ram3 346 28 of of IN cord-029547-9ei1ram3 346 29 SARS SARS NNP cord-029547-9ei1ram3 346 30 - - HYPH cord-029547-9ei1ram3 346 31 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 346 32 SARS SARS NNP cord-029547-9ei1ram3 346 33 - - HYPH cord-029547-9ei1ram3 346 34 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 346 35 and and CC cord-029547-9ei1ram3 346 36 viral viral JJ cord-029547-9ei1ram3 346 37 sepsis sepsis NN cord-029547-9ei1ram3 346 38 : : : cord-029547-9ei1ram3 346 39 observations observation NNS cord-029547-9ei1ram3 346 40 and and CC cord-029547-9ei1ram3 346 41 hypotheses hypothesis NNS cord-029547-9ei1ram3 347 1 Structural structural JJ cord-029547-9ei1ram3 347 2 insights insight NNS cord-029547-9ei1ram3 347 3 into into IN cord-029547-9ei1ram3 347 4 coronavirus coronavirus NN cord-029547-9ei1ram3 347 5 entry entry NN cord-029547-9ei1ram3 347 6 Fusion Fusion NNP cord-029547-9ei1ram3 347 7 mechanism mechanism NN cord-029547-9ei1ram3 347 8 of of IN cord-029547-9ei1ram3 347 9 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 347 10 and and CC cord-029547-9ei1ram3 347 11 fusion fusion NN cord-029547-9ei1ram3 347 12 inhibitors inhibitor NNS cord-029547-9ei1ram3 347 13 targeting target VBG cord-029547-9ei1ram3 347 14 HR1 HR1 NNP cord-029547-9ei1ram3 347 15 domain domain NN cord-029547-9ei1ram3 347 16 in in IN cord-029547-9ei1ram3 347 17 spike spike NN cord-029547-9ei1ram3 347 18 protein protein NN cord-029547-9ei1ram3 347 19 SARS SARS NNP cord-029547-9ei1ram3 347 20 - - HYPH cord-029547-9ei1ram3 347 21 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 347 22 cell cell NN cord-029547-9ei1ram3 347 23 entry entry NN cord-029547-9ei1ram3 347 24 depends depend VBZ cord-029547-9ei1ram3 347 25 on on IN cord-029547-9ei1ram3 347 26 ACE2 ACE2 NNP cord-029547-9ei1ram3 347 27 and and CC cord-029547-9ei1ram3 347 28 TMPRSS2 TMPRSS2 NNP cord-029547-9ei1ram3 347 29 and and CC cord-029547-9ei1ram3 347 30 is be VBZ cord-029547-9ei1ram3 347 31 blocked block VBN cord-029547-9ei1ram3 347 32 by by IN cord-029547-9ei1ram3 347 33 a a DT cord-029547-9ei1ram3 347 34 clinically clinically RB cord-029547-9ei1ram3 347 35 proven prove VBN cord-029547-9ei1ram3 347 36 protease protease NN cord-029547-9ei1ram3 347 37 inhibitor inhibitor NN cord-029547-9ei1ram3 347 38 Rigidity rigidity NN cord-029547-9ei1ram3 347 39 of of IN cord-029547-9ei1ram3 347 40 the the DT cord-029547-9ei1ram3 347 41 outer outer JJ cord-029547-9ei1ram3 347 42 shell shell NN cord-029547-9ei1ram3 347 43 predicted predict VBN cord-029547-9ei1ram3 347 44 by by IN cord-029547-9ei1ram3 347 45 a a DT cord-029547-9ei1ram3 347 46 protein protein NN cord-029547-9ei1ram3 347 47 intrinsic intrinsic JJ cord-029547-9ei1ram3 347 48 disorder disorder NN cord-029547-9ei1ram3 347 49 model model NN cord-029547-9ei1ram3 347 50 sheds shed VBZ cord-029547-9ei1ram3 347 51 light light NN cord-029547-9ei1ram3 347 52 on on IN cord-029547-9ei1ram3 347 53 the the DT cord-029547-9ei1ram3 347 54 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 347 55 ( ( -LRB- cord-029547-9ei1ram3 347 56 Wuhan-2019-nCoV wuhan-2019-ncov NN cord-029547-9ei1ram3 347 57 ) ) -RRB- cord-029547-9ei1ram3 347 58 infectivity infectivity NN cord-029547-9ei1ram3 347 59 Altered alter VBD cord-029547-9ei1ram3 347 60 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 347 61 receptor receptor NN cord-029547-9ei1ram3 347 62 ACE2 ACE2 NNP cord-029547-9ei1ram3 347 63 expression expression NN cord-029547-9ei1ram3 347 64 in in IN cord-029547-9ei1ram3 347 65 a a DT cord-029547-9ei1ram3 347 66 higher high JJR cord-029547-9ei1ram3 347 67 risk risk NN cord-029547-9ei1ram3 347 68 group group NN cord-029547-9ei1ram3 347 69 for for IN cord-029547-9ei1ram3 347 70 cerebrovascular cerebrovascular JJ cord-029547-9ei1ram3 347 71 disease disease NN cord-029547-9ei1ram3 347 72 and and CC cord-029547-9ei1ram3 347 73 ischemic ischemic JJ cord-029547-9ei1ram3 347 74 stroke stroke NN cord-029547-9ei1ram3 347 75 Information information NN cord-029547-9ei1ram3 347 76 about about IN cord-029547-9ei1ram3 347 77 the the DT cord-029547-9ei1ram3 347 78 current current JJ cord-029547-9ei1ram3 347 79 situation situation NN cord-029547-9ei1ram3 347 80 of of IN cord-029547-9ei1ram3 347 81 pneumonia pneumonia NN cord-029547-9ei1ram3 347 82 in in IN cord-029547-9ei1ram3 347 83 Wuhan Wuhan NNP cord-029547-9ei1ram3 347 84 WHO WHO NNP cord-029547-9ei1ram3 347 85 . . . cord-029547-9ei1ram3 348 1 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 348 2 disease disease NN cord-029547-9ei1ram3 348 3 2019 2019 CD cord-029547-9ei1ram3 349 1 ( ( -LRB- cord-029547-9ei1ram3 349 2 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 349 3 ) ) -RRB- cord-029547-9ei1ram3 349 4 Situation Situation NNP cord-029547-9ei1ram3 349 5 Report Report NNP cord-029547-9ei1ram3 349 6 -117 -117 NNP cord-029547-9ei1ram3 350 1 Incubation incubation NN cord-029547-9ei1ram3 350 2 period period NN cord-029547-9ei1ram3 350 3 and and CC cord-029547-9ei1ram3 350 4 other other JJ cord-029547-9ei1ram3 350 5 epidemiological epidemiological JJ cord-029547-9ei1ram3 350 6 characteristics characteristic NNS cord-029547-9ei1ram3 350 7 of of IN cord-029547-9ei1ram3 350 8 2019 2019 CD cord-029547-9ei1ram3 350 9 novel novel JJ cord-029547-9ei1ram3 350 10 coronavirus coronavirus NN cord-029547-9ei1ram3 350 11 infections infection NNS cord-029547-9ei1ram3 350 12 with with IN cord-029547-9ei1ram3 350 13 right right JJ cord-029547-9ei1ram3 350 14 truncation truncation NN cord-029547-9ei1ram3 350 15 : : : cord-029547-9ei1ram3 350 16 a a DT cord-029547-9ei1ram3 350 17 statistical statistical JJ cord-029547-9ei1ram3 350 18 analysis analysis NN cord-029547-9ei1ram3 350 19 of of IN cord-029547-9ei1ram3 351 1 publicly publicly RB cord-029547-9ei1ram3 351 2 available available JJ cord-029547-9ei1ram3 351 3 case case NN cord-029547-9ei1ram3 351 4 data datum NNS cord-029547-9ei1ram3 352 1 A a DT cord-029547-9ei1ram3 352 2 familial familial JJ cord-029547-9ei1ram3 352 3 cluster cluster NN cord-029547-9ei1ram3 352 4 of of IN cord-029547-9ei1ram3 352 5 pneumonia pneumonia NN cord-029547-9ei1ram3 352 6 associated associate VBN cord-029547-9ei1ram3 352 7 with with IN cord-029547-9ei1ram3 352 8 the the DT cord-029547-9ei1ram3 352 9 2019 2019 CD cord-029547-9ei1ram3 352 10 novel novel NN cord-029547-9ei1ram3 352 11 coronavirus coronavirus NN cord-029547-9ei1ram3 352 12 indicating indicate VBG cord-029547-9ei1ram3 352 13 person person NN cord-029547-9ei1ram3 352 14 - - HYPH cord-029547-9ei1ram3 352 15 to to IN cord-029547-9ei1ram3 352 16 - - HYPH cord-029547-9ei1ram3 352 17 person person NN cord-029547-9ei1ram3 352 18 transmission transmission NN cord-029547-9ei1ram3 352 19 : : : cord-029547-9ei1ram3 352 20 a a DT cord-029547-9ei1ram3 352 21 study study NN cord-029547-9ei1ram3 352 22 of of IN cord-029547-9ei1ram3 352 23 a a DT cord-029547-9ei1ram3 352 24 family family NN cord-029547-9ei1ram3 352 25 cluster cluster NN cord-029547-9ei1ram3 352 26 Characteristics characteristic NNS cord-029547-9ei1ram3 352 27 of of IN cord-029547-9ei1ram3 352 28 ocular ocular JJ cord-029547-9ei1ram3 352 29 findings finding NNS cord-029547-9ei1ram3 352 30 of of IN cord-029547-9ei1ram3 352 31 patients patient NNS cord-029547-9ei1ram3 352 32 with with IN cord-029547-9ei1ram3 352 33 coronavirus coronavirus NN cord-029547-9ei1ram3 352 34 disease disease NN cord-029547-9ei1ram3 352 35 2019 2019 CD cord-029547-9ei1ram3 352 36 ( ( -LRB- cord-029547-9ei1ram3 352 37 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 352 38 Enteric enteric JJ cord-029547-9ei1ram3 352 39 involvement involvement NN cord-029547-9ei1ram3 352 40 of of IN cord-029547-9ei1ram3 352 41 coronaviruses coronaviruse NNS cord-029547-9ei1ram3 352 42 : : : cord-029547-9ei1ram3 352 43 is be VBZ cord-029547-9ei1ram3 352 44 faecal faecal JJ cord-029547-9ei1ram3 352 45 - - HYPH cord-029547-9ei1ram3 352 46 oral oral JJ cord-029547-9ei1ram3 352 47 transmission transmission NN cord-029547-9ei1ram3 352 48 of of IN cord-029547-9ei1ram3 352 49 SARS SARS NNP cord-029547-9ei1ram3 352 50 - - HYPH cord-029547-9ei1ram3 352 51 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 352 52 possible possible JJ cord-029547-9ei1ram3 352 53 ? ? . cord-029547-9ei1ram3 353 1 Characteristics characteristic NNS cord-029547-9ei1ram3 353 2 of of IN cord-029547-9ei1ram3 353 3 pediatric pediatric JJ cord-029547-9ei1ram3 353 4 SARS SARS NNP cord-029547-9ei1ram3 353 5 - - HYPH cord-029547-9ei1ram3 353 6 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 353 7 infection infection NN cord-029547-9ei1ram3 353 8 and and CC cord-029547-9ei1ram3 353 9 potential potential JJ cord-029547-9ei1ram3 353 10 evidence evidence NN cord-029547-9ei1ram3 353 11 for for IN cord-029547-9ei1ram3 353 12 persistent persistent JJ cord-029547-9ei1ram3 353 13 fecal fecal JJ cord-029547-9ei1ram3 353 14 viral viral JJ cord-029547-9ei1ram3 353 15 shedding shed VBG cord-029547-9ei1ram3 353 16 Detection Detection NNP cord-029547-9ei1ram3 353 17 of of IN cord-029547-9ei1ram3 353 18 SARS SARS NNP cord-029547-9ei1ram3 353 19 - - HYPH cord-029547-9ei1ram3 353 20 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 353 21 in in IN cord-029547-9ei1ram3 353 22 different different JJ cord-029547-9ei1ram3 353 23 types type NNS cord-029547-9ei1ram3 353 24 of of IN cord-029547-9ei1ram3 353 25 clinical clinical JJ cord-029547-9ei1ram3 353 26 specimens specimen NNS cord-029547-9ei1ram3 353 27 Possible possible JJ cord-029547-9ei1ram3 353 28 vertical vertical JJ cord-029547-9ei1ram3 353 29 transmission transmission NN cord-029547-9ei1ram3 353 30 of of IN cord-029547-9ei1ram3 353 31 SARS SARS NNP cord-029547-9ei1ram3 353 32 - - HYPH cord-029547-9ei1ram3 353 33 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 353 34 from from IN cord-029547-9ei1ram3 353 35 an an DT cord-029547-9ei1ram3 353 36 infected infected JJ cord-029547-9ei1ram3 353 37 mother mother NN cord-029547-9ei1ram3 353 38 to to IN cord-029547-9ei1ram3 353 39 her -PRON- PRP$ cord-029547-9ei1ram3 353 40 newborn newborn JJ cord-029547-9ei1ram3 353 41 Clinical clinical JJ cord-029547-9ei1ram3 353 42 characteristics characteristic NNS cord-029547-9ei1ram3 353 43 and and CC cord-029547-9ei1ram3 353 44 intrauterine intrauterine JJ cord-029547-9ei1ram3 353 45 vertical vertical JJ cord-029547-9ei1ram3 353 46 transmission transmission NN cord-029547-9ei1ram3 353 47 potential potential NN cord-029547-9ei1ram3 353 48 of of IN cord-029547-9ei1ram3 353 49 COVID-19 covid-19 JJ cord-029547-9ei1ram3 353 50 infection infection NN cord-029547-9ei1ram3 353 51 in in IN cord-029547-9ei1ram3 353 52 nine nine CD cord-029547-9ei1ram3 353 53 pregnant pregnant JJ cord-029547-9ei1ram3 353 54 women woman NNS cord-029547-9ei1ram3 353 55 : : : cord-029547-9ei1ram3 353 56 a a DT cord-029547-9ei1ram3 353 57 retrospective retrospective JJ cord-029547-9ei1ram3 353 58 review review NN cord-029547-9ei1ram3 353 59 of of IN cord-029547-9ei1ram3 353 60 medical medical JJ cord-029547-9ei1ram3 353 61 records record NNS cord-029547-9ei1ram3 353 62 Novel Novel NNP cord-029547-9ei1ram3 353 63 coronavirus coronavirus NN cord-029547-9ei1ram3 353 64 infection infection NN cord-029547-9ei1ram3 353 65 in in IN cord-029547-9ei1ram3 353 66 hospitalized hospitalize VBN cord-029547-9ei1ram3 353 67 infants infant NNS cord-029547-9ei1ram3 353 68 under under IN cord-029547-9ei1ram3 353 69 1 1 CD cord-029547-9ei1ram3 353 70 year year NN cord-029547-9ei1ram3 353 71 of of IN cord-029547-9ei1ram3 353 72 age age NN cord-029547-9ei1ram3 353 73 in in IN cord-029547-9ei1ram3 353 74 China China NNP cord-029547-9ei1ram3 353 75 Antibodies Antibodies NNP cord-029547-9ei1ram3 353 76 in in IN cord-029547-9ei1ram3 353 77 infants infant NNS cord-029547-9ei1ram3 353 78 born bear VBN cord-029547-9ei1ram3 353 79 to to IN cord-029547-9ei1ram3 353 80 mothers mother NNS cord-029547-9ei1ram3 353 81 with with IN cord-029547-9ei1ram3 353 82 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 353 83 pneumonia pneumonia NN cord-029547-9ei1ram3 354 1 The the DT cord-029547-9ei1ram3 354 2 Novel Novel NNP cord-029547-9ei1ram3 354 3 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 354 4 Pneumonia Pneumonia NNP cord-029547-9ei1ram3 354 5 Emergency Emergency NNP cord-029547-9ei1ram3 354 6 Response Response NNP cord-029547-9ei1ram3 354 7 Epidemiology Epidemiology NNP cord-029547-9ei1ram3 354 8 . . . cord-029547-9ei1ram3 355 1 The the DT cord-029547-9ei1ram3 355 2 epidemiological epidemiological JJ cord-029547-9ei1ram3 355 3 characteristics characteristic NNS cord-029547-9ei1ram3 355 4 of of IN cord-029547-9ei1ram3 355 5 an an DT cord-029547-9ei1ram3 355 6 outbreak outbreak NN cord-029547-9ei1ram3 355 7 of of IN cord-029547-9ei1ram3 355 8 2019 2019 CD cord-029547-9ei1ram3 355 9 novel novel JJ cord-029547-9ei1ram3 355 10 coronavirus coronavirus NN cord-029547-9ei1ram3 355 11 diseases disease NNS cord-029547-9ei1ram3 355 12 ( ( -LRB- cord-029547-9ei1ram3 355 13 COVID-19)-China COVID-19)-China NNP cord-029547-9ei1ram3 355 14 Severe severe JJ cord-029547-9ei1ram3 355 15 outcomes outcome NNS cord-029547-9ei1ram3 355 16 among among IN cord-029547-9ei1ram3 355 17 patients patient NNS cord-029547-9ei1ram3 355 18 with with IN cord-029547-9ei1ram3 355 19 coronavirus coronavirus NN cord-029547-9ei1ram3 355 20 disease disease NN cord-029547-9ei1ram3 355 21 2019 2019 CD cord-029547-9ei1ram3 355 22 ( ( -LRB- cord-029547-9ei1ram3 355 23 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 355 24 ) ) -RRB- cord-029547-9ei1ram3 355 25 -United -unite VBD cord-029547-9ei1ram3 355 26 States States NNP cord-029547-9ei1ram3 355 27 High High NNP cord-029547-9ei1ram3 355 28 contagiousness contagiousness NN cord-029547-9ei1ram3 355 29 and and CC cord-029547-9ei1ram3 355 30 rapid rapid JJ cord-029547-9ei1ram3 355 31 spread spread NN cord-029547-9ei1ram3 355 32 of of IN cord-029547-9ei1ram3 355 33 severe severe JJ cord-029547-9ei1ram3 355 34 acute acute JJ cord-029547-9ei1ram3 355 35 respiratory respiratory JJ cord-029547-9ei1ram3 355 36 syndrome syndrome NN cord-029547-9ei1ram3 355 37 coronavirus coronavirus NN cord-029547-9ei1ram3 355 38 2 2 CD cord-029547-9ei1ram3 355 39 Report Report NNP cord-029547-9ei1ram3 355 40 13 13 CD cord-029547-9ei1ram3 356 1 -Estimating -estimate VBG cord-029547-9ei1ram3 357 1 the the DT cord-029547-9ei1ram3 357 2 number number NN cord-029547-9ei1ram3 357 3 of of IN cord-029547-9ei1ram3 357 4 infections infection NNS cord-029547-9ei1ram3 357 5 and and CC cord-029547-9ei1ram3 357 6 the the DT cord-029547-9ei1ram3 357 7 impact impact NN cord-029547-9ei1ram3 357 8 of of IN cord-029547-9ei1ram3 357 9 non non JJ cord-029547-9ei1ram3 357 10 - - JJ cord-029547-9ei1ram3 357 11 pharmaceutical pharmaceutical JJ cord-029547-9ei1ram3 357 12 interventions intervention NNS cord-029547-9ei1ram3 357 13 on on IN cord-029547-9ei1ram3 357 14 COVID-19 covid-19 CD cord-029547-9ei1ram3 357 15 in in IN cord-029547-9ei1ram3 357 16 11 11 CD cord-029547-9ei1ram3 357 17 European european JJ cord-029547-9ei1ram3 357 18 countries country NNS cord-029547-9ei1ram3 357 19 Characteristics characteristic NNS cord-029547-9ei1ram3 357 20 of of IN cord-029547-9ei1ram3 357 21 and and CC cord-029547-9ei1ram3 357 22 important important JJ cord-029547-9ei1ram3 357 23 lessons lesson NNS cord-029547-9ei1ram3 357 24 from from IN cord-029547-9ei1ram3 357 25 the the DT cord-029547-9ei1ram3 357 26 coronavirus coronavirus NN cord-029547-9ei1ram3 357 27 disease disease NN cord-029547-9ei1ram3 357 28 2019 2019 CD cord-029547-9ei1ram3 357 29 ( ( -LRB- cord-029547-9ei1ram3 357 30 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 357 31 ) ) -RRB- cord-029547-9ei1ram3 357 32 outbreak outbreak NN cord-029547-9ei1ram3 357 33 in in IN cord-029547-9ei1ram3 357 34 China China NNP cord-029547-9ei1ram3 357 35 : : : cord-029547-9ei1ram3 357 36 summary summary NN cord-029547-9ei1ram3 357 37 of of IN cord-029547-9ei1ram3 357 38 a a DT cord-029547-9ei1ram3 357 39 report report NN cord-029547-9ei1ram3 357 40 of of IN cord-029547-9ei1ram3 357 41 72314 72314 CD cord-029547-9ei1ram3 357 42 cases case NNS cord-029547-9ei1ram3 357 43 from from IN cord-029547-9ei1ram3 357 44 the the DT cord-029547-9ei1ram3 357 45 Chinese Chinese NNP cord-029547-9ei1ram3 357 46 Center Center NNP cord-029547-9ei1ram3 357 47 for for IN cord-029547-9ei1ram3 357 48 Disease Disease NNP cord-029547-9ei1ram3 357 49 Control Control NNP cord-029547-9ei1ram3 357 50 and and CC cord-029547-9ei1ram3 357 51 Prevention Prevention NNP cord-029547-9ei1ram3 357 52 Epidemiologic Epidemiologic NNP cord-029547-9ei1ram3 357 53 and and CC cord-029547-9ei1ram3 357 54 clinical clinical JJ cord-029547-9ei1ram3 357 55 characteristics characteristic NNS cord-029547-9ei1ram3 357 56 of of IN cord-029547-9ei1ram3 357 57 novel novel JJ cord-029547-9ei1ram3 357 58 coronavirus coronavirus NN cord-029547-9ei1ram3 357 59 infections infection NNS cord-029547-9ei1ram3 357 60 involving involve VBG cord-029547-9ei1ram3 357 61 13 13 CD cord-029547-9ei1ram3 357 62 patients patient NNS cord-029547-9ei1ram3 357 63 outside outside IN cord-029547-9ei1ram3 357 64 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 65 , , , cord-029547-9ei1ram3 357 66 China China NNP cord-029547-9ei1ram3 357 67 Estimating estimate VBG cord-029547-9ei1ram3 357 68 clinical clinical JJ cord-029547-9ei1ram3 357 69 severity severity NN cord-029547-9ei1ram3 357 70 of of IN cord-029547-9ei1ram3 357 71 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 357 72 from from IN cord-029547-9ei1ram3 357 73 the the DT cord-029547-9ei1ram3 357 74 transmission transmission NN cord-029547-9ei1ram3 357 75 dynamics dynamic NNS cord-029547-9ei1ram3 357 76 in in IN cord-029547-9ei1ram3 357 77 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 78 , , , cord-029547-9ei1ram3 357 79 China China NNP cord-029547-9ei1ram3 357 80 Clinical clinical JJ cord-029547-9ei1ram3 357 81 characteristics characteristic NNS cord-029547-9ei1ram3 357 82 of of IN cord-029547-9ei1ram3 357 83 coronavirus coronavirus NN cord-029547-9ei1ram3 357 84 disease disease NN cord-029547-9ei1ram3 357 85 2019 2019 CD cord-029547-9ei1ram3 357 86 in in IN cord-029547-9ei1ram3 357 87 China China NNP cord-029547-9ei1ram3 357 88 Epidemiological epidemiological JJ cord-029547-9ei1ram3 357 89 and and CC cord-029547-9ei1ram3 357 90 clinical clinical JJ cord-029547-9ei1ram3 357 91 characteristics characteristic NNS cord-029547-9ei1ram3 357 92 of of IN cord-029547-9ei1ram3 357 93 99 99 CD cord-029547-9ei1ram3 357 94 cases case NNS cord-029547-9ei1ram3 357 95 of of IN cord-029547-9ei1ram3 357 96 2019 2019 CD cord-029547-9ei1ram3 357 97 novel novel JJ cord-029547-9ei1ram3 357 98 coronavirus coronavirus NN cord-029547-9ei1ram3 357 99 pneumonia pneumonia NN cord-029547-9ei1ram3 357 100 in in IN cord-029547-9ei1ram3 357 101 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 102 , , , cord-029547-9ei1ram3 357 103 China China NNP cord-029547-9ei1ram3 357 104 : : : cord-029547-9ei1ram3 357 105 a a DT cord-029547-9ei1ram3 357 106 descriptive descriptive JJ cord-029547-9ei1ram3 357 107 study study NN cord-029547-9ei1ram3 357 108 Clinical clinical JJ cord-029547-9ei1ram3 357 109 characteristics characteristic NNS cord-029547-9ei1ram3 357 110 of of IN cord-029547-9ei1ram3 357 111 138 138 CD cord-029547-9ei1ram3 357 112 hospitalized hospitalize VBN cord-029547-9ei1ram3 357 113 patients patient NNS cord-029547-9ei1ram3 357 114 with with IN cord-029547-9ei1ram3 357 115 2019 2019 CD cord-029547-9ei1ram3 357 116 novel novel JJ cord-029547-9ei1ram3 357 117 coronavirusinfected coronavirusinfecte VBN cord-029547-9ei1ram3 357 118 pneumonia pneumonia NN cord-029547-9ei1ram3 357 119 in in IN cord-029547-9ei1ram3 357 120 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 121 , , , cord-029547-9ei1ram3 357 122 China China NNP cord-029547-9ei1ram3 357 123 Characteristics Characteristics NNPS cord-029547-9ei1ram3 357 124 and and CC cord-029547-9ei1ram3 357 125 outcomes outcome NNS cord-029547-9ei1ram3 357 126 of of IN cord-029547-9ei1ram3 357 127 21 21 CD cord-029547-9ei1ram3 357 128 critically critically RB cord-029547-9ei1ram3 357 129 Ill ill JJ cord-029547-9ei1ram3 357 130 patients patient NNS cord-029547-9ei1ram3 357 131 with with IN cord-029547-9ei1ram3 357 132 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 357 133 in in IN cord-029547-9ei1ram3 357 134 Washington Washington NNP cord-029547-9ei1ram3 357 135 State State NNP cord-029547-9ei1ram3 357 136 Clinical Clinical NNP cord-029547-9ei1ram3 357 137 findings finding NNS cord-029547-9ei1ram3 357 138 in in IN cord-029547-9ei1ram3 357 139 a a DT cord-029547-9ei1ram3 357 140 group group NN cord-029547-9ei1ram3 357 141 of of IN cord-029547-9ei1ram3 357 142 patients patient NNS cord-029547-9ei1ram3 357 143 infected infect VBN cord-029547-9ei1ram3 357 144 with with IN cord-029547-9ei1ram3 357 145 the the DT cord-029547-9ei1ram3 357 146 2019 2019 CD cord-029547-9ei1ram3 357 147 novel novel NN cord-029547-9ei1ram3 357 148 coronavirus coronavirus NN cord-029547-9ei1ram3 357 149 ( ( -LRB- cord-029547-9ei1ram3 357 150 SARS SARS NNP cord-029547-9ei1ram3 357 151 - - HYPH cord-029547-9ei1ram3 357 152 Cov-2 Cov-2 NNP cord-029547-9ei1ram3 357 153 ) ) -RRB- cord-029547-9ei1ram3 357 154 outside outside IN cord-029547-9ei1ram3 357 155 of of IN cord-029547-9ei1ram3 357 156 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 157 , , , cord-029547-9ei1ram3 357 158 China China NNP cord-029547-9ei1ram3 357 159 : : : cord-029547-9ei1ram3 357 160 retrospective retrospective JJ cord-029547-9ei1ram3 357 161 case case NN cord-029547-9ei1ram3 357 162 series series NN cord-029547-9ei1ram3 357 163 Clinical clinical JJ cord-029547-9ei1ram3 357 164 characteristics characteristic NNS cord-029547-9ei1ram3 357 165 of of IN cord-029547-9ei1ram3 357 166 140 140 CD cord-029547-9ei1ram3 357 167 patients patient NNS cord-029547-9ei1ram3 357 168 infected infect VBN cord-029547-9ei1ram3 357 169 with with IN cord-029547-9ei1ram3 357 170 SARS SARS NNP cord-029547-9ei1ram3 357 171 - - HYPH cord-029547-9ei1ram3 357 172 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 357 173 in in IN cord-029547-9ei1ram3 357 174 Wuhan Wuhan NNP cord-029547-9ei1ram3 357 175 novel novel JJ cord-029547-9ei1ram3 357 176 coronavirus coronavirus NN cord-029547-9ei1ram3 357 177 ( ( -LRB- cord-029547-9ei1ram3 357 178 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 357 179 ) ) -RRB- cord-029547-9ei1ram3 357 180 pneumonia pneumonia NN cord-029547-9ei1ram3 357 181 : : : cord-029547-9ei1ram3 357 182 serial serial JJ cord-029547-9ei1ram3 357 183 computed compute VBN cord-029547-9ei1ram3 357 184 tomography tomography NN cord-029547-9ei1ram3 357 185 findings finding NNS cord-029547-9ei1ram3 357 186 Clinical clinical JJ cord-029547-9ei1ram3 357 187 characteristics characteristic NNS cord-029547-9ei1ram3 357 188 of of IN cord-029547-9ei1ram3 357 189 coronavirus coronavirus NN cord-029547-9ei1ram3 357 190 disease disease NN cord-029547-9ei1ram3 357 191 2019 2019 CD cord-029547-9ei1ram3 357 192 in in IN cord-029547-9ei1ram3 357 193 China China NNP cord-029547-9ei1ram3 358 1 The the DT cord-029547-9ei1ram3 358 2 clinical clinical JJ cord-029547-9ei1ram3 358 3 and and CC cord-029547-9ei1ram3 358 4 chest chest NN cord-029547-9ei1ram3 358 5 CT CT NNP cord-029547-9ei1ram3 358 6 features feature VBZ cord-029547-9ei1ram3 358 7 associated associate VBN cord-029547-9ei1ram3 358 8 with with IN cord-029547-9ei1ram3 358 9 severe severe JJ cord-029547-9ei1ram3 358 10 and and CC cord-029547-9ei1ram3 358 11 critical critical JJ cord-029547-9ei1ram3 358 12 COVID-19 covid-19 JJ cord-029547-9ei1ram3 358 13 pneumonia pneumonia NN cord-029547-9ei1ram3 358 14 Diagnosis Diagnosis NNP cord-029547-9ei1ram3 358 15 and and CC cord-029547-9ei1ram3 358 16 Treatment Treatment NNP cord-029547-9ei1ram3 358 17 Program Program NNP cord-029547-9ei1ram3 358 18 of of IN cord-029547-9ei1ram3 358 19 Novel Novel NNP cord-029547-9ei1ram3 358 20 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 358 21 Pneumonia Pneumonia NNP cord-029547-9ei1ram3 359 1 ( ( -LRB- cord-029547-9ei1ram3 359 2 trial trial JJ cord-029547-9ei1ram3 359 3 seventh seventh JJ cord-029547-9ei1ram3 359 4 version version NN cord-029547-9ei1ram3 359 5 Therapeutic therapeutic JJ cord-029547-9ei1ram3 359 6 and and CC cord-029547-9ei1ram3 359 7 triage triage NN cord-029547-9ei1ram3 359 8 strategies strategy NNS cord-029547-9ei1ram3 359 9 for for IN cord-029547-9ei1ram3 359 10 2019 2019 CD cord-029547-9ei1ram3 359 11 novel novel JJ cord-029547-9ei1ram3 359 12 coronavirus coronavirus NN cord-029547-9ei1ram3 359 13 disease disease NN cord-029547-9ei1ram3 359 14 in in IN cord-029547-9ei1ram3 359 15 fever fever NN cord-029547-9ei1ram3 359 16 clinics clinic NNS cord-029547-9ei1ram3 359 17 Correlation Correlation NNP cord-029547-9ei1ram3 359 18 of of IN cord-029547-9ei1ram3 359 19 chest chest NN cord-029547-9ei1ram3 359 20 CT CT NNP cord-029547-9ei1ram3 359 21 and and CC cord-029547-9ei1ram3 359 22 RT RT NNP cord-029547-9ei1ram3 359 23 - - HYPH cord-029547-9ei1ram3 359 24 PCR PCR NNP cord-029547-9ei1ram3 359 25 testing testing NN cord-029547-9ei1ram3 359 26 in in IN cord-029547-9ei1ram3 359 27 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 359 28 Disease Disease NNP cord-029547-9ei1ram3 359 29 2019 2019 CD cord-029547-9ei1ram3 359 30 ( ( -LRB- cord-029547-9ei1ram3 359 31 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 359 32 ) ) -RRB- cord-029547-9ei1ram3 359 33 in in IN cord-029547-9ei1ram3 359 34 China China NNP cord-029547-9ei1ram3 359 35 : : : cord-029547-9ei1ram3 359 36 a a DT cord-029547-9ei1ram3 359 37 report report NN cord-029547-9ei1ram3 359 38 of of IN cord-029547-9ei1ram3 359 39 1014 1014 CD cord-029547-9ei1ram3 359 40 cases case NNS cord-029547-9ei1ram3 359 41 Clinical clinical JJ cord-029547-9ei1ram3 359 42 features feature NNS cord-029547-9ei1ram3 359 43 of of IN cord-029547-9ei1ram3 359 44 patients patient NNS cord-029547-9ei1ram3 359 45 infected infect VBN cord-029547-9ei1ram3 359 46 with with IN cord-029547-9ei1ram3 359 47 2019 2019 CD cord-029547-9ei1ram3 359 48 novel novel JJ cord-029547-9ei1ram3 359 49 coronavirus coronavirus NN cord-029547-9ei1ram3 359 50 in in IN cord-029547-9ei1ram3 359 51 Wuhan Wuhan NNP cord-029547-9ei1ram3 359 52 , , , cord-029547-9ei1ram3 359 53 China China NNP cord-029547-9ei1ram3 359 54 Temporal temporal JJ cord-029547-9ei1ram3 359 55 profiles profile NNS cord-029547-9ei1ram3 359 56 of of IN cord-029547-9ei1ram3 359 57 viral viral JJ cord-029547-9ei1ram3 359 58 load load NN cord-029547-9ei1ram3 359 59 in in IN cord-029547-9ei1ram3 359 60 posterior posterior JJ cord-029547-9ei1ram3 359 61 oropharyngeal oropharyngeal JJ cord-029547-9ei1ram3 359 62 saliva saliva NN cord-029547-9ei1ram3 359 63 samples sample NNS cord-029547-9ei1ram3 359 64 and and CC cord-029547-9ei1ram3 359 65 serum serum NN cord-029547-9ei1ram3 359 66 antibody antibody NN cord-029547-9ei1ram3 359 67 responses response NNS cord-029547-9ei1ram3 359 68 during during IN cord-029547-9ei1ram3 359 69 infection infection NN cord-029547-9ei1ram3 359 70 by by IN cord-029547-9ei1ram3 359 71 SARS SARS NNP cord-029547-9ei1ram3 359 72 - - HYPH cord-029547-9ei1ram3 359 73 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 359 74 : : : cord-029547-9ei1ram3 360 1 an an DT cord-029547-9ei1ram3 360 2 observational observational JJ cord-029547-9ei1ram3 360 3 cohort cohort NN cord-029547-9ei1ram3 360 4 study study NN cord-029547-9ei1ram3 360 5 Profiling profile VBG cord-029547-9ei1ram3 360 6 early early JJ cord-029547-9ei1ram3 360 7 humoral humoral JJ cord-029547-9ei1ram3 360 8 response response NN cord-029547-9ei1ram3 360 9 to to TO cord-029547-9ei1ram3 360 10 diagnose diagnose VB cord-029547-9ei1ram3 360 11 novel novel JJ cord-029547-9ei1ram3 360 12 coronavirus coronavirus NN cord-029547-9ei1ram3 360 13 disease disease NN cord-029547-9ei1ram3 360 14 ( ( -LRB- cord-029547-9ei1ram3 360 15 COVID-19 covid-19 VB cord-029547-9ei1ram3 360 16 ) ) -RRB- cord-029547-9ei1ram3 361 1 Time time NN cord-029547-9ei1ram3 361 2 course course NN cord-029547-9ei1ram3 361 3 of of IN cord-029547-9ei1ram3 361 4 lung lung NN cord-029547-9ei1ram3 361 5 changes change NNS cord-029547-9ei1ram3 361 6 on on IN cord-029547-9ei1ram3 361 7 chest chest NN cord-029547-9ei1ram3 361 8 CT CT NNP cord-029547-9ei1ram3 361 9 during during IN cord-029547-9ei1ram3 361 10 recovery recovery NN cord-029547-9ei1ram3 361 11 from from IN cord-029547-9ei1ram3 361 12 2019 2019 CD cord-029547-9ei1ram3 361 13 novel novel JJ cord-029547-9ei1ram3 361 14 coronavirus coronavirus NN cord-029547-9ei1ram3 361 15 ( ( -LRB- cord-029547-9ei1ram3 361 16 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 361 17 ) ) -RRB- cord-029547-9ei1ram3 361 18 pneumonia pneumonia NN cord-029547-9ei1ram3 361 19 Clinically clinically RB cord-029547-9ei1ram3 361 20 applicable applicable JJ cord-029547-9ei1ram3 361 21 AI ai NN cord-029547-9ei1ram3 361 22 system system NN cord-029547-9ei1ram3 361 23 for for IN cord-029547-9ei1ram3 361 24 accurate accurate JJ cord-029547-9ei1ram3 361 25 diagnosis diagnosis NN cord-029547-9ei1ram3 361 26 , , , cord-029547-9ei1ram3 361 27 quantitative quantitative JJ cord-029547-9ei1ram3 361 28 measurements measurement NNS cord-029547-9ei1ram3 361 29 , , , cord-029547-9ei1ram3 361 30 and and CC cord-029547-9ei1ram3 361 31 prognosis prognosis NN cord-029547-9ei1ram3 361 32 of of IN cord-029547-9ei1ram3 361 33 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 361 34 pneumonia pneumonia NN cord-029547-9ei1ram3 361 35 using use VBG cord-029547-9ei1ram3 361 36 computed compute VBN cord-029547-9ei1ram3 361 37 tomography tomography NN cord-029547-9ei1ram3 361 38 CRISPR CRISPR NNP cord-029547-9ei1ram3 361 39 - - HYPH cord-029547-9ei1ram3 361 40 Cas12-based cas12-base VBN cord-029547-9ei1ram3 361 41 detection detection NN cord-029547-9ei1ram3 361 42 of of IN cord-029547-9ei1ram3 361 43 SARS SARS NNP cord-029547-9ei1ram3 361 44 - - HYPH cord-029547-9ei1ram3 361 45 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 361 46 Remdesivir Remdesivir NNP cord-029547-9ei1ram3 361 47 and and CC cord-029547-9ei1ram3 361 48 chloroquine chloroquine NN cord-029547-9ei1ram3 361 49 effectively effectively RB cord-029547-9ei1ram3 361 50 inhibit inhibit VBP cord-029547-9ei1ram3 361 51 the the DT cord-029547-9ei1ram3 361 52 recently recently RB cord-029547-9ei1ram3 361 53 emerged emerge VBN cord-029547-9ei1ram3 361 54 novel novel JJ cord-029547-9ei1ram3 361 55 coronavirus coronavirus NN cord-029547-9ei1ram3 361 56 ( ( -LRB- cord-029547-9ei1ram3 361 57 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 361 58 ) ) -RRB- cord-029547-9ei1ram3 361 59 in in IN cord-029547-9ei1ram3 361 60 vitro vitro FW cord-029547-9ei1ram3 361 61 Breakthrough Breakthrough NNP cord-029547-9ei1ram3 361 62 : : : cord-029547-9ei1ram3 361 63 chloroquine chloroquine NN cord-029547-9ei1ram3 361 64 phosphate phosphate NN cord-029547-9ei1ram3 361 65 has have VBZ cord-029547-9ei1ram3 361 66 shown show VBN cord-029547-9ei1ram3 361 67 apparent apparent JJ cord-029547-9ei1ram3 361 68 efficacy efficacy NN cord-029547-9ei1ram3 361 69 in in IN cord-029547-9ei1ram3 361 70 treatment treatment NN cord-029547-9ei1ram3 361 71 of of IN cord-029547-9ei1ram3 361 72 COVID-19 covid-19 JJ cord-029547-9ei1ram3 361 73 associated associated JJ cord-029547-9ei1ram3 361 74 pneumonia pneumonia NN cord-029547-9ei1ram3 361 75 in in IN cord-029547-9ei1ram3 361 76 clinical clinical JJ cord-029547-9ei1ram3 361 77 studies study NNS cord-029547-9ei1ram3 361 78 Chloroquine Chloroquine NNP cord-029547-9ei1ram3 361 79 for for IN cord-029547-9ei1ram3 361 80 the the DT cord-029547-9ei1ram3 361 81 2019 2019 CD cord-029547-9ei1ram3 361 82 novel novel NN cord-029547-9ei1ram3 361 83 coronavirus coronavirus NN cord-029547-9ei1ram3 361 84 SARS SARS NNP cord-029547-9ei1ram3 361 85 - - HYPH cord-029547-9ei1ram3 361 86 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 361 87 Effect Effect NNP cord-029547-9ei1ram3 361 88 of of IN cord-029547-9ei1ram3 361 89 high high JJ cord-029547-9ei1ram3 361 90 vs vs IN cord-029547-9ei1ram3 361 91 low low JJ cord-029547-9ei1ram3 361 92 doses dose NNS cord-029547-9ei1ram3 361 93 of of IN cord-029547-9ei1ram3 361 94 chloroquine chloroquine NN cord-029547-9ei1ram3 361 95 diphosphate diphosphate NN cord-029547-9ei1ram3 361 96 as as IN cord-029547-9ei1ram3 361 97 adjunctive adjunctive JJ cord-029547-9ei1ram3 361 98 therapy therapy NN cord-029547-9ei1ram3 361 99 for for IN cord-029547-9ei1ram3 361 100 patients patient NNS cord-029547-9ei1ram3 361 101 hospitalized hospitalize VBN cord-029547-9ei1ram3 361 102 with with IN cord-029547-9ei1ram3 361 103 severe severe JJ cord-029547-9ei1ram3 361 104 acute acute JJ cord-029547-9ei1ram3 361 105 respiratory respiratory JJ cord-029547-9ei1ram3 361 106 syndrome syndrome NN cord-029547-9ei1ram3 361 107 coronavirus coronavirus NN cord-029547-9ei1ram3 361 108 2 2 CD cord-029547-9ei1ram3 362 1 ( ( -LRB- cord-029547-9ei1ram3 362 2 SARS SARS NNP cord-029547-9ei1ram3 362 3 - - HYPH cord-029547-9ei1ram3 362 4 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 362 5 ) ) -RRB- cord-029547-9ei1ram3 362 6 infection infection NN cord-029547-9ei1ram3 362 7 : : : cord-029547-9ei1ram3 362 8 a a DT cord-029547-9ei1ram3 362 9 randomized randomized JJ cord-029547-9ei1ram3 362 10 clinical clinical JJ cord-029547-9ei1ram3 362 11 trial trial NN cord-029547-9ei1ram3 363 1 The the DT cord-029547-9ei1ram3 363 2 QT QT NNP cord-029547-9ei1ram3 363 3 interval interval NN cord-029547-9ei1ram3 363 4 in in IN cord-029547-9ei1ram3 363 5 patients patient NNS cord-029547-9ei1ram3 363 6 with with IN cord-029547-9ei1ram3 363 7 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 363 8 treated treat VBN cord-029547-9ei1ram3 363 9 with with IN cord-029547-9ei1ram3 363 10 hydroxychloroquine hydroxychloroquine NN cord-029547-9ei1ram3 363 11 and and CC cord-029547-9ei1ram3 363 12 azithromycin azithromycin NNP cord-029547-9ei1ram3 363 13 Clinical clinical JJ cord-029547-9ei1ram3 363 14 features feature NNS cord-029547-9ei1ram3 363 15 of of IN cord-029547-9ei1ram3 363 16 69 69 CD cord-029547-9ei1ram3 363 17 cases case NNS cord-029547-9ei1ram3 363 18 with with IN cord-029547-9ei1ram3 363 19 coronavirus coronavirus NN cord-029547-9ei1ram3 363 20 disease disease NN cord-029547-9ei1ram3 363 21 2019 2019 CD cord-029547-9ei1ram3 363 22 in in IN cord-029547-9ei1ram3 363 23 Wuhan Wuhan NNP cord-029547-9ei1ram3 363 24 , , , cord-029547-9ei1ram3 363 25 China China NNP cord-029547-9ei1ram3 363 26 . . . cord-029547-9ei1ram3 364 1 Clin Clin NNP cord-029547-9ei1ram3 364 2 Infectious Infectious NNP cord-029547-9ei1ram3 364 3 Dis Dis NNP cord-029547-9ei1ram3 364 4 Arbidol Arbidol NNP cord-029547-9ei1ram3 364 5 combined combine VBN cord-029547-9ei1ram3 364 6 with with IN cord-029547-9ei1ram3 364 7 LPV LPV NNP cord-029547-9ei1ram3 364 8 / / SYM cord-029547-9ei1ram3 364 9 r r NN cord-029547-9ei1ram3 364 10 versus versus IN cord-029547-9ei1ram3 364 11 LPV LPV NNP cord-029547-9ei1ram3 364 12 / / SYM cord-029547-9ei1ram3 364 13 r r NN cord-029547-9ei1ram3 364 14 alone alone RB cord-029547-9ei1ram3 364 15 against against IN cord-029547-9ei1ram3 364 16 corona corona NN cord-029547-9ei1ram3 364 17 virus virus NN cord-029547-9ei1ram3 364 18 disease disease NNP cord-029547-9ei1ram3 364 19 2019 2019 CD cord-029547-9ei1ram3 365 1 : : : cord-029547-9ei1ram3 365 2 a a DT cord-029547-9ei1ram3 365 3 retrospective retrospective JJ cord-029547-9ei1ram3 365 4 cohort cohort NN cord-029547-9ei1ram3 365 5 study study NN cord-029547-9ei1ram3 366 1 Umifenovir Umifenovir NNP cord-029547-9ei1ram3 366 2 treatment treatment NN cord-029547-9ei1ram3 366 3 is be VBZ cord-029547-9ei1ram3 366 4 not not RB cord-029547-9ei1ram3 366 5 associated associate VBN cord-029547-9ei1ram3 366 6 with with IN cord-029547-9ei1ram3 366 7 improved improved JJ cord-029547-9ei1ram3 366 8 outcomes outcome NNS cord-029547-9ei1ram3 366 9 in in IN cord-029547-9ei1ram3 366 10 patients patient NNS cord-029547-9ei1ram3 366 11 with with IN cord-029547-9ei1ram3 366 12 coronavirus coronavirus NN cord-029547-9ei1ram3 366 13 disease disease NN cord-029547-9ei1ram3 366 14 2019 2019 CD cord-029547-9ei1ram3 366 15 : : : cord-029547-9ei1ram3 366 16 a a DT cord-029547-9ei1ram3 366 17 retrospective retrospective JJ cord-029547-9ei1ram3 366 18 study study NN cord-029547-9ei1ram3 366 19 Structure Structure NNP cord-029547-9ei1ram3 366 20 of of IN cord-029547-9ei1ram3 366 21 the the DT cord-029547-9ei1ram3 366 22 RNAdependent RNAdependent NNP cord-029547-9ei1ram3 366 23 RNA RNA NNP cord-029547-9ei1ram3 366 24 polymerase polymerase NN cord-029547-9ei1ram3 366 25 from from IN cord-029547-9ei1ram3 366 26 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 366 27 virus virus NN cord-029547-9ei1ram3 366 28 Structural structural JJ cord-029547-9ei1ram3 366 29 basis basis NN cord-029547-9ei1ram3 366 30 for for IN cord-029547-9ei1ram3 366 31 inhibition inhibition NN cord-029547-9ei1ram3 366 32 of of IN cord-029547-9ei1ram3 366 33 the the DT cord-029547-9ei1ram3 366 34 RNA RNA NNP cord-029547-9ei1ram3 366 35 - - HYPH cord-029547-9ei1ram3 366 36 dependent dependent JJ cord-029547-9ei1ram3 366 37 RNA RNA NNP cord-029547-9ei1ram3 366 38 polymerase polymerase NN cord-029547-9ei1ram3 366 39 from from IN cord-029547-9ei1ram3 366 40 SARS SARS NNP cord-029547-9ei1ram3 366 41 - - HYPH cord-029547-9ei1ram3 366 42 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 366 43 by by IN cord-029547-9ei1ram3 366 44 remdesivir remdesivir NNP cord-029547-9ei1ram3 366 45 First First NNP cord-029547-9ei1ram3 366 46 case case NN cord-029547-9ei1ram3 366 47 of of IN cord-029547-9ei1ram3 366 48 2019 2019 CD cord-029547-9ei1ram3 366 49 novel novel JJ cord-029547-9ei1ram3 366 50 coronavirus coronavirus NN cord-029547-9ei1ram3 366 51 in in IN cord-029547-9ei1ram3 366 52 the the DT cord-029547-9ei1ram3 366 53 United United NNP cord-029547-9ei1ram3 366 54 States States NNP cord-029547-9ei1ram3 366 55 Compassionate compassionate JJ cord-029547-9ei1ram3 366 56 use use NN cord-029547-9ei1ram3 366 57 of of IN cord-029547-9ei1ram3 366 58 remdesivir remdesivir NNS cord-029547-9ei1ram3 366 59 for for IN cord-029547-9ei1ram3 366 60 patients patient NNS cord-029547-9ei1ram3 366 61 with with IN cord-029547-9ei1ram3 366 62 severe severe JJ cord-029547-9ei1ram3 366 63 Covid-19 covid-19 NN cord-029547-9ei1ram3 366 64 A A NNP cord-029547-9ei1ram3 366 65 randomized randomize VBN cord-029547-9ei1ram3 366 66 , , , cord-029547-9ei1ram3 366 67 controlled control VBN cord-029547-9ei1ram3 366 68 trial trial NN cord-029547-9ei1ram3 366 69 of of IN cord-029547-9ei1ram3 366 70 ebola ebola NNP cord-029547-9ei1ram3 366 71 virus virus NN cord-029547-9ei1ram3 366 72 disease disease NN cord-029547-9ei1ram3 366 73 therapeutics therapeutics NNP cord-029547-9ei1ram3 366 74 Remdesivir Remdesivir NNP cord-029547-9ei1ram3 366 75 in in IN cord-029547-9ei1ram3 366 76 adults adult NNS cord-029547-9ei1ram3 366 77 with with IN cord-029547-9ei1ram3 366 78 severe severe JJ cord-029547-9ei1ram3 366 79 COVID-19 covid-19 NN cord-029547-9ei1ram3 366 80 : : : cord-029547-9ei1ram3 366 81 a a DT cord-029547-9ei1ram3 366 82 randomised randomised JJ cord-029547-9ei1ram3 366 83 , , , cord-029547-9ei1ram3 366 84 double double JJ cord-029547-9ei1ram3 366 85 - - HYPH cord-029547-9ei1ram3 366 86 blind blind JJ cord-029547-9ei1ram3 366 87 , , , cord-029547-9ei1ram3 366 88 placebo placebo NN cord-029547-9ei1ram3 366 89 - - HYPH cord-029547-9ei1ram3 366 90 controlled control VBN cord-029547-9ei1ram3 366 91 , , , cord-029547-9ei1ram3 366 92 multicentre multicentre NNP cord-029547-9ei1ram3 366 93 trial trial NN cord-029547-9ei1ram3 366 94 National National NNP cord-029547-9ei1ram3 366 95 Institutes Institutes NNPS cord-029547-9ei1ram3 366 96 of of IN cord-029547-9ei1ram3 366 97 Health Health NNP cord-029547-9ei1ram3 366 98 . . . cord-029547-9ei1ram3 367 1 NIH NIH NNP cord-029547-9ei1ram3 367 2 Clinical Clinical NNP cord-029547-9ei1ram3 367 3 Trial Trial NNP cord-029547-9ei1ram3 367 4 Shows show VBZ cord-029547-9ei1ram3 367 5 Remdesivir Remdesivir NNP cord-029547-9ei1ram3 367 6 Accelerates accelerate VBZ cord-029547-9ei1ram3 367 7 Recovery Recovery NNP cord-029547-9ei1ram3 367 8 from from IN cord-029547-9ei1ram3 367 9 Advanced Advanced NNP cord-029547-9ei1ram3 367 10 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 367 11 Anti Anti NNP cord-029547-9ei1ram3 367 12 - - NNP cord-029547-9ei1ram3 367 13 HCV HCV NNP cord-029547-9ei1ram3 367 14 , , , cord-029547-9ei1ram3 367 15 nucleotide nucleotide JJ cord-029547-9ei1ram3 367 16 inhibitors inhibitor NNS cord-029547-9ei1ram3 367 17 , , , cord-029547-9ei1ram3 367 18 repurposing repurpose VBG cord-029547-9ei1ram3 367 19 against against IN cord-029547-9ei1ram3 367 20 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 367 21 More More JJR cord-029547-9ei1ram3 367 22 than than IN cord-029547-9ei1ram3 367 23 80 80 CD cord-029547-9ei1ram3 367 24 clinical clinical JJ cord-029547-9ei1ram3 367 25 trials trial NNS cord-029547-9ei1ram3 367 26 launch launch VBP cord-029547-9ei1ram3 367 27 to to TO cord-029547-9ei1ram3 367 28 test test VB cord-029547-9ei1ram3 367 29 coronavirus coronavirus NN cord-029547-9ei1ram3 367 30 treatments treatment NNS cord-029547-9ei1ram3 367 31 Epidemiologic epidemiologic JJ cord-029547-9ei1ram3 367 32 features feature NNS cord-029547-9ei1ram3 367 33 and and CC cord-029547-9ei1ram3 367 34 clinical clinical JJ cord-029547-9ei1ram3 367 35 course course NN cord-029547-9ei1ram3 367 36 of of IN cord-029547-9ei1ram3 367 37 patients patient NNS cord-029547-9ei1ram3 367 38 infected infect VBN cord-029547-9ei1ram3 367 39 with with IN cord-029547-9ei1ram3 367 40 SARS SARS NNP cord-029547-9ei1ram3 367 41 - - HYPH cord-029547-9ei1ram3 367 42 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 367 43 in in IN cord-029547-9ei1ram3 367 44 Singapore Singapore NNP cord-029547-9ei1ram3 368 1 A a DT cord-029547-9ei1ram3 368 2 trial trial NN cord-029547-9ei1ram3 368 3 of of IN cord-029547-9ei1ram3 368 4 Lopinavir Lopinavir NNP cord-029547-9ei1ram3 368 5 - - HYPH cord-029547-9ei1ram3 368 6 Ritonavir Ritonavir NNP cord-029547-9ei1ram3 368 7 in in IN cord-029547-9ei1ram3 368 8 adults adult NNS cord-029547-9ei1ram3 368 9 hospitalized hospitalize VBN cord-029547-9ei1ram3 368 10 with with IN cord-029547-9ei1ram3 368 11 severe severe JJ cord-029547-9ei1ram3 368 12 Covid-19 covid-19 NN cord-029547-9ei1ram3 368 13 A A NNP cord-029547-9ei1ram3 368 14 trial trial NN cord-029547-9ei1ram3 368 15 of of IN cord-029547-9ei1ram3 368 16 Lopinavir Lopinavir NNP cord-029547-9ei1ram3 368 17 - - HYPH cord-029547-9ei1ram3 368 18 Ritonavir Ritonavir NNP cord-029547-9ei1ram3 368 19 in in IN cord-029547-9ei1ram3 368 20 adults adult NNS cord-029547-9ei1ram3 368 21 hospitalized hospitalize VBN cord-029547-9ei1ram3 368 22 with with IN cord-029547-9ei1ram3 368 23 severe severe JJ cord-029547-9ei1ram3 368 24 Covid-19 covid-19 NN cord-029547-9ei1ram3 368 25 Effect effect NN cord-029547-9ei1ram3 368 26 of of IN cord-029547-9ei1ram3 368 27 interferon interferon NN cord-029547-9ei1ram3 368 28 alpha alpha NN cord-029547-9ei1ram3 368 29 and and CC cord-029547-9ei1ram3 368 30 cyclosporine cyclosporine JJ cord-029547-9ei1ram3 368 31 treatment treatment NN cord-029547-9ei1ram3 368 32 separately separately RB cord-029547-9ei1ram3 368 33 and and CC cord-029547-9ei1ram3 368 34 in in IN cord-029547-9ei1ram3 368 35 combination combination NN cord-029547-9ei1ram3 368 36 on on IN cord-029547-9ei1ram3 368 37 Middle Middle NNP cord-029547-9ei1ram3 368 38 East East NNP cord-029547-9ei1ram3 368 39 Respiratory Respiratory NNP cord-029547-9ei1ram3 368 40 Syndrome Syndrome NNP cord-029547-9ei1ram3 368 41 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 368 42 ( ( -LRB- cord-029547-9ei1ram3 368 43 MERS MERS NNP cord-029547-9ei1ram3 368 44 - - HYPH cord-029547-9ei1ram3 368 45 CoV CoV NNP cord-029547-9ei1ram3 368 46 ) ) -RRB- cord-029547-9ei1ram3 368 47 replication replication NN cord-029547-9ei1ram3 368 48 in in IN cord-029547-9ei1ram3 368 49 a a DT cord-029547-9ei1ram3 368 50 human human NN cord-029547-9ei1ram3 368 51 in in IN cord-029547-9ei1ram3 368 52 - - HYPH cord-029547-9ei1ram3 368 53 vitro vitro FW cord-029547-9ei1ram3 368 54 and and CC cord-029547-9ei1ram3 368 55 ex ex JJ cord-029547-9ei1ram3 368 56 - - JJ cord-029547-9ei1ram3 368 57 vivo vivo JJ cord-029547-9ei1ram3 368 58 culture culture NN cord-029547-9ei1ram3 368 59 model model NN cord-029547-9ei1ram3 368 60 Therapeutic therapeutic JJ cord-029547-9ei1ram3 368 61 options option NNS cord-029547-9ei1ram3 368 62 for for IN cord-029547-9ei1ram3 368 63 the the DT cord-029547-9ei1ram3 368 64 2019 2019 CD cord-029547-9ei1ram3 368 65 novel novel NN cord-029547-9ei1ram3 368 66 coronavirus coronavirus NN cord-029547-9ei1ram3 368 67 ( ( -LRB- cord-029547-9ei1ram3 368 68 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 368 69 ) ) -RRB- cord-029547-9ei1ram3 368 70 Triple triple JJ cord-029547-9ei1ram3 368 71 combination combination NN cord-029547-9ei1ram3 368 72 of of IN cord-029547-9ei1ram3 368 73 interferon interferon NN cord-029547-9ei1ram3 368 74 beta-1b beta-1b NNP cord-029547-9ei1ram3 368 75 , , , cord-029547-9ei1ram3 368 76 lopinavir lopinavir NNS cord-029547-9ei1ram3 368 77 - - HYPH cord-029547-9ei1ram3 368 78 ritonavir ritonavir NNS cord-029547-9ei1ram3 368 79 , , , cord-029547-9ei1ram3 368 80 and and CC cord-029547-9ei1ram3 368 81 ribavirin ribavirin NN cord-029547-9ei1ram3 368 82 in in IN cord-029547-9ei1ram3 368 83 the the DT cord-029547-9ei1ram3 368 84 treatment treatment NN cord-029547-9ei1ram3 368 85 of of IN cord-029547-9ei1ram3 368 86 patients patient NNS cord-029547-9ei1ram3 368 87 admitted admit VBN cord-029547-9ei1ram3 368 88 to to IN cord-029547-9ei1ram3 368 89 hospital hospital NN cord-029547-9ei1ram3 368 90 with with IN cord-029547-9ei1ram3 368 91 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 368 92 : : : cord-029547-9ei1ram3 368 93 an an DT cord-029547-9ei1ram3 368 94 open open JJ cord-029547-9ei1ram3 368 95 - - HYPH cord-029547-9ei1ram3 368 96 label label NN cord-029547-9ei1ram3 368 97 , , , cord-029547-9ei1ram3 368 98 randomised randomised JJ cord-029547-9ei1ram3 368 99 , , , cord-029547-9ei1ram3 368 100 phase phase NN cord-029547-9ei1ram3 368 101 2 2 CD cord-029547-9ei1ram3 368 102 trial trial NN cord-029547-9ei1ram3 368 103 Convalescent convalescent JJ cord-029547-9ei1ram3 368 104 plasma plasma NN cord-029547-9ei1ram3 368 105 as as IN cord-029547-9ei1ram3 368 106 a a DT cord-029547-9ei1ram3 368 107 potential potential JJ cord-029547-9ei1ram3 368 108 therapy therapy NN cord-029547-9ei1ram3 368 109 for for IN cord-029547-9ei1ram3 368 110 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 368 111 Treatment Treatment NNP cord-029547-9ei1ram3 368 112 of of IN cord-029547-9ei1ram3 368 113 5 5 CD cord-029547-9ei1ram3 368 114 critically critically RB cord-029547-9ei1ram3 368 115 Ill ill JJ cord-029547-9ei1ram3 368 116 patients patient NNS cord-029547-9ei1ram3 368 117 with with IN cord-029547-9ei1ram3 368 118 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 368 119 with with IN cord-029547-9ei1ram3 368 120 convalescent convalescent JJ cord-029547-9ei1ram3 368 121 plasma plasma NN cord-029547-9ei1ram3 368 122 A a DT cord-029547-9ei1ram3 368 123 human human JJ cord-029547-9ei1ram3 368 124 monoclonal monoclonal JJ cord-029547-9ei1ram3 368 125 antibody antibody NN cord-029547-9ei1ram3 368 126 blocking block VBG cord-029547-9ei1ram3 368 127 SARS SARS NNP cord-029547-9ei1ram3 368 128 - - HYPH cord-029547-9ei1ram3 368 129 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 368 130 infection infection NN cord-029547-9ei1ram3 369 1 A a DT cord-029547-9ei1ram3 369 2 noncompeting noncompeting JJ cord-029547-9ei1ram3 369 3 pair pair NN cord-029547-9ei1ram3 369 4 of of IN cord-029547-9ei1ram3 369 5 human human JJ cord-029547-9ei1ram3 369 6 neutralizing neutralize VBG cord-029547-9ei1ram3 369 7 antibodies antibody NNS cord-029547-9ei1ram3 369 8 block block VBP cord-029547-9ei1ram3 369 9 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 369 10 virus virus NN cord-029547-9ei1ram3 369 11 binding bind VBG cord-029547-9ei1ram3 369 12 to to IN cord-029547-9ei1ram3 369 13 its -PRON- PRP$ cord-029547-9ei1ram3 369 14 receptor receptor NN cord-029547-9ei1ram3 369 15 ACE2 ACE2 NNP cord-029547-9ei1ram3 369 16 Potent Potent NNP cord-029547-9ei1ram3 369 17 binding binding NN cord-029547-9ei1ram3 369 18 of of IN cord-029547-9ei1ram3 369 19 2019 2019 CD cord-029547-9ei1ram3 369 20 novel novel JJ cord-029547-9ei1ram3 369 21 coronavirus coronavirus NN cord-029547-9ei1ram3 369 22 spike spike NN cord-029547-9ei1ram3 369 23 protein protein NN cord-029547-9ei1ram3 369 24 by by IN cord-029547-9ei1ram3 369 25 a a DT cord-029547-9ei1ram3 369 26 SARS SARS NNP cord-029547-9ei1ram3 369 27 coronavirusspecific coronavirusspecific NNP cord-029547-9ei1ram3 369 28 human human JJ cord-029547-9ei1ram3 369 29 monoclonal monoclonal JJ cord-029547-9ei1ram3 369 30 antibody antibody NN cord-029547-9ei1ram3 369 31 Clinical clinical JJ cord-029547-9ei1ram3 369 32 and and CC cord-029547-9ei1ram3 369 33 epidemiological epidemiological JJ cord-029547-9ei1ram3 369 34 features feature NNS cord-029547-9ei1ram3 369 35 of of IN cord-029547-9ei1ram3 369 36 36 36 CD cord-029547-9ei1ram3 369 37 children child NNS cord-029547-9ei1ram3 369 38 with with IN cord-029547-9ei1ram3 369 39 coronavirus coronavirus NN cord-029547-9ei1ram3 369 40 disease disease NN cord-029547-9ei1ram3 369 41 2019 2019 CD cord-029547-9ei1ram3 369 42 ( ( -LRB- cord-029547-9ei1ram3 369 43 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 369 44 ) ) -RRB- cord-029547-9ei1ram3 369 45 in in IN cord-029547-9ei1ram3 369 46 Zhejiang Zhejiang NNP cord-029547-9ei1ram3 369 47 , , , cord-029547-9ei1ram3 369 48 China China NNP cord-029547-9ei1ram3 369 49 : : : cord-029547-9ei1ram3 370 1 an an DT cord-029547-9ei1ram3 370 2 observational observational JJ cord-029547-9ei1ram3 370 3 cohort cohort NN cord-029547-9ei1ram3 370 4 study study NN cord-029547-9ei1ram3 370 5 The the DT cord-029547-9ei1ram3 370 6 Italian italian JJ cord-029547-9ei1ram3 370 7 coronavirus coronavirus NN cord-029547-9ei1ram3 370 8 disease disease NN cord-029547-9ei1ram3 370 9 2019 2019 CD cord-029547-9ei1ram3 370 10 outbreak outbreak NN cord-029547-9ei1ram3 370 11 : : : cord-029547-9ei1ram3 370 12 recommendations recommendation NNS cord-029547-9ei1ram3 370 13 from from IN cord-029547-9ei1ram3 370 14 clinical clinical JJ cord-029547-9ei1ram3 370 15 practice practice NN cord-029547-9ei1ram3 370 16 Clinical clinical JJ cord-029547-9ei1ram3 370 17 characteristics characteristic NNS cord-029547-9ei1ram3 370 18 of of IN cord-029547-9ei1ram3 370 19 113 113 CD cord-029547-9ei1ram3 370 20 deceased deceased JJ cord-029547-9ei1ram3 370 21 patients patient NNS cord-029547-9ei1ram3 370 22 with with IN cord-029547-9ei1ram3 370 23 coronavirus coronavirus NN cord-029547-9ei1ram3 370 24 disease disease NN cord-029547-9ei1ram3 370 25 2019 2019 CD cord-029547-9ei1ram3 370 26 : : : cord-029547-9ei1ram3 370 27 retrospective retrospective JJ cord-029547-9ei1ram3 370 28 study study NN cord-029547-9ei1ram3 371 1 Dexamethasone dexamethasone NN cord-029547-9ei1ram3 371 2 treatment treatment NN cord-029547-9ei1ram3 371 3 for for IN cord-029547-9ei1ram3 371 4 the the DT cord-029547-9ei1ram3 371 5 acute acute JJ cord-029547-9ei1ram3 371 6 respiratory respiratory JJ cord-029547-9ei1ram3 371 7 distress distress NN cord-029547-9ei1ram3 371 8 syndrome syndrome NN cord-029547-9ei1ram3 371 9 : : : cord-029547-9ei1ram3 371 10 a a DT cord-029547-9ei1ram3 371 11 multicentre multicentre NNP cord-029547-9ei1ram3 371 12 , , , cord-029547-9ei1ram3 371 13 randomised randomised JJ cord-029547-9ei1ram3 371 14 controlled control VBN cord-029547-9ei1ram3 371 15 trial trial NN cord-029547-9ei1ram3 371 16 Clinical clinical JJ cord-029547-9ei1ram3 371 17 evidence evidence NN cord-029547-9ei1ram3 371 18 does do VBZ cord-029547-9ei1ram3 371 19 not not RB cord-029547-9ei1ram3 371 20 support support VB cord-029547-9ei1ram3 371 21 corticosteroid corticosteroid NN cord-029547-9ei1ram3 371 22 treatment treatment NN cord-029547-9ei1ram3 371 23 for for IN cord-029547-9ei1ram3 371 24 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 371 25 lung lung NNP cord-029547-9ei1ram3 371 26 injury injury NN cord-029547-9ei1ram3 371 27 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 371 28 : : : cord-029547-9ei1ram3 371 29 combining combine VBG cord-029547-9ei1ram3 371 30 antiviral antiviral JJ cord-029547-9ei1ram3 371 31 and and CC cord-029547-9ei1ram3 371 32 anti anti JJ cord-029547-9ei1ram3 371 33 - - JJ cord-029547-9ei1ram3 371 34 inflammatory inflammatory JJ cord-029547-9ei1ram3 371 35 treatments treatment NNS cord-029547-9ei1ram3 371 36 Controversial controversial JJ cord-029547-9ei1ram3 371 37 treatments treatment NNS cord-029547-9ei1ram3 371 38 : : : cord-029547-9ei1ram3 372 1 an an DT cord-029547-9ei1ram3 372 2 updated update VBN cord-029547-9ei1ram3 372 3 understanding understanding NN cord-029547-9ei1ram3 372 4 of of IN cord-029547-9ei1ram3 372 5 the the DT cord-029547-9ei1ram3 372 6 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 372 7 Disease Disease NNP cord-029547-9ei1ram3 372 8 Impact Impact NNP cord-029547-9ei1ram3 372 9 of of IN cord-029547-9ei1ram3 372 10 concomitant concomitant JJ cord-029547-9ei1ram3 372 11 vasoactive vasoactive JJ cord-029547-9ei1ram3 372 12 treatment treatment NN cord-029547-9ei1ram3 372 13 and and CC cord-029547-9ei1ram3 372 14 mechanical mechanical JJ cord-029547-9ei1ram3 372 15 left left JJ cord-029547-9ei1ram3 372 16 ventricular ventricular JJ cord-029547-9ei1ram3 372 17 unloading unloading NN cord-029547-9ei1ram3 372 18 in in IN cord-029547-9ei1ram3 372 19 a a DT cord-029547-9ei1ram3 372 20 porcine porcine JJ cord-029547-9ei1ram3 372 21 model model NN cord-029547-9ei1ram3 372 22 of of IN cord-029547-9ei1ram3 372 23 profound profound JJ cord-029547-9ei1ram3 372 24 cardiogenic cardiogenic JJ cord-029547-9ei1ram3 372 25 shock shock NN cord-029547-9ei1ram3 372 26 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 372 27 disease disease NN cord-029547-9ei1ram3 373 1 19 19 CD cord-029547-9ei1ram3 373 2 infection infection NN cord-029547-9ei1ram3 373 3 does do VBZ cord-029547-9ei1ram3 373 4 not not RB cord-029547-9ei1ram3 373 5 result result VB cord-029547-9ei1ram3 373 6 in in IN cord-029547-9ei1ram3 373 7 acute acute JJ cord-029547-9ei1ram3 373 8 kidney kidney NN cord-029547-9ei1ram3 373 9 injury injury NN cord-029547-9ei1ram3 373 10 : : : cord-029547-9ei1ram3 373 11 An an DT cord-029547-9ei1ram3 373 12 analysis analysis NN cord-029547-9ei1ram3 373 13 of of IN cord-029547-9ei1ram3 373 14 116 116 CD cord-029547-9ei1ram3 373 15 hospitalized hospitalize VBN cord-029547-9ei1ram3 373 16 patients patient NNS cord-029547-9ei1ram3 373 17 from from IN cord-029547-9ei1ram3 373 18 Wuhan Wuhan NNP cord-029547-9ei1ram3 373 19 , , , cord-029547-9ei1ram3 373 20 China China NNP cord-029547-9ei1ram3 373 21 Early early RB cord-029547-9ei1ram3 373 22 acute acute JJ cord-029547-9ei1ram3 373 23 respiratory respiratory JJ cord-029547-9ei1ram3 373 24 support support NN cord-029547-9ei1ram3 373 25 for for IN cord-029547-9ei1ram3 373 26 pregnant pregnant JJ cord-029547-9ei1ram3 373 27 patients patient NNS cord-029547-9ei1ram3 373 28 with with IN cord-029547-9ei1ram3 373 29 coronavirus coronavirus NN cord-029547-9ei1ram3 373 30 disease disease NN cord-029547-9ei1ram3 373 31 2019 2019 CD cord-029547-9ei1ram3 373 32 ( ( -LRB- cord-029547-9ei1ram3 373 33 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 373 34 ) ) -RRB- cord-029547-9ei1ram3 373 35 infection infection NN cord-029547-9ei1ram3 373 36 Preparing prepare VBG cord-029547-9ei1ram3 373 37 for for IN cord-029547-9ei1ram3 373 38 the the DT cord-029547-9ei1ram3 373 39 most most RBS cord-029547-9ei1ram3 373 40 critically critically RB cord-029547-9ei1ram3 373 41 Ill ill JJ cord-029547-9ei1ram3 373 42 patients patient NNS cord-029547-9ei1ram3 373 43 with with IN cord-029547-9ei1ram3 373 44 COVID-19 covid-19 CD cord-029547-9ei1ram3 373 45 : : : cord-029547-9ei1ram3 373 46 the the DT cord-029547-9ei1ram3 373 47 potential potential JJ cord-029547-9ei1ram3 373 48 role role NN cord-029547-9ei1ram3 373 49 of of IN cord-029547-9ei1ram3 373 50 extracorporeal extracorporeal JJ cord-029547-9ei1ram3 373 51 membrane membrane NN cord-029547-9ei1ram3 373 52 oxygenation oxygenation NN cord-029547-9ei1ram3 373 53 Therapeutic therapeutic JJ cord-029547-9ei1ram3 373 54 use use NN cord-029547-9ei1ram3 373 55 of of IN cord-029547-9ei1ram3 373 56 extracellular extracellular JJ cord-029547-9ei1ram3 373 57 vesicles vesicle NNS cord-029547-9ei1ram3 373 58 for for IN cord-029547-9ei1ram3 373 59 acute acute JJ cord-029547-9ei1ram3 373 60 and and CC cord-029547-9ei1ram3 373 61 chronic chronic JJ cord-029547-9ei1ram3 373 62 lung lung NN cord-029547-9ei1ram3 373 63 disease disease NN cord-029547-9ei1ram3 374 1 Expanded expand VBN cord-029547-9ei1ram3 374 2 umbilical umbilical JJ cord-029547-9ei1ram3 374 3 cord cord NN cord-029547-9ei1ram3 374 4 mesenchymal mesenchymal JJ cord-029547-9ei1ram3 374 5 stem stem NN cord-029547-9ei1ram3 374 6 cells cell NNS cord-029547-9ei1ram3 374 7 ( ( -LRB- cord-029547-9ei1ram3 374 8 UC UC NNP cord-029547-9ei1ram3 374 9 - - HYPH cord-029547-9ei1ram3 374 10 MSCs MSCs NNP cord-029547-9ei1ram3 374 11 ) ) -RRB- cord-029547-9ei1ram3 374 12 as as IN cord-029547-9ei1ram3 374 13 a a DT cord-029547-9ei1ram3 374 14 therapeutic therapeutic JJ cord-029547-9ei1ram3 374 15 strategy strategy NN cord-029547-9ei1ram3 374 16 in in IN cord-029547-9ei1ram3 374 17 managing manage VBG cord-029547-9ei1ram3 374 18 critically critically RB cord-029547-9ei1ram3 374 19 Ill ill JJ cord-029547-9ei1ram3 375 1 COVID-19 covid-19 JJ cord-029547-9ei1ram3 375 2 patients patient NNS cord-029547-9ei1ram3 375 3 : : : cord-029547-9ei1ram3 375 4 the the DT cord-029547-9ei1ram3 375 5 case case NN cord-029547-9ei1ram3 375 6 for for IN cord-029547-9ei1ram3 375 7 compassionate compassionate JJ cord-029547-9ei1ram3 375 8 use use NN cord-029547-9ei1ram3 375 9 Hypercoagulation Hypercoagulation NNP cord-029547-9ei1ram3 375 10 and and CC cord-029547-9ei1ram3 375 11 antithrombotic antithrombotic JJ cord-029547-9ei1ram3 375 12 treatment treatment NN cord-029547-9ei1ram3 375 13 in in IN cord-029547-9ei1ram3 375 14 coronavirus coronavirus NN cord-029547-9ei1ram3 375 15 2019 2019 CD cord-029547-9ei1ram3 375 16 : : : cord-029547-9ei1ram3 375 17 a a DT cord-029547-9ei1ram3 375 18 new new JJ cord-029547-9ei1ram3 375 19 challenge challenge NN cord-029547-9ei1ram3 375 20 Association Association NNP cord-029547-9ei1ram3 375 21 of of IN cord-029547-9ei1ram3 375 22 coronavirus coronavirus NNP cord-029547-9ei1ram3 375 23 disease disease NNP cord-029547-9ei1ram3 375 24 2019 2019 CD cord-029547-9ei1ram3 375 25 ( ( -LRB- cord-029547-9ei1ram3 375 26 COVID-19 covid-19 VB cord-029547-9ei1ram3 375 27 ) ) -RRB- cord-029547-9ei1ram3 375 28 with with IN cord-029547-9ei1ram3 375 29 myocardial myocardial JJ cord-029547-9ei1ram3 375 30 injury injury NN cord-029547-9ei1ram3 375 31 and and CC cord-029547-9ei1ram3 375 32 mortality mortality NN cord-029547-9ei1ram3 375 33 Clinical clinical JJ cord-029547-9ei1ram3 375 34 course course NN cord-029547-9ei1ram3 375 35 and and CC cord-029547-9ei1ram3 375 36 risk risk NN cord-029547-9ei1ram3 375 37 factors factor NNS cord-029547-9ei1ram3 375 38 for for IN cord-029547-9ei1ram3 375 39 mortality mortality NN cord-029547-9ei1ram3 375 40 of of IN cord-029547-9ei1ram3 375 41 adult adult NN cord-029547-9ei1ram3 375 42 inpatients inpatient NNS cord-029547-9ei1ram3 375 43 with with IN cord-029547-9ei1ram3 375 44 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 375 45 in in IN cord-029547-9ei1ram3 375 46 Wuhan Wuhan NNP cord-029547-9ei1ram3 375 47 , , , cord-029547-9ei1ram3 375 48 China China NNP cord-029547-9ei1ram3 375 49 : : : cord-029547-9ei1ram3 375 50 a a DT cord-029547-9ei1ram3 375 51 retrospective retrospective JJ cord-029547-9ei1ram3 375 52 cohort cohort NN cord-029547-9ei1ram3 375 53 study study NN cord-029547-9ei1ram3 375 54 Role role NN cord-029547-9ei1ram3 375 55 of of IN cord-029547-9ei1ram3 375 56 dipeptidyl dipeptidyl JJ cord-029547-9ei1ram3 375 57 peptidase peptidase NN cord-029547-9ei1ram3 375 58 4 4 CD cord-029547-9ei1ram3 375 59 inhibitors inhibitor NNS cord-029547-9ei1ram3 375 60 in in IN cord-029547-9ei1ram3 375 61 diabetic diabetic JJ cord-029547-9ei1ram3 375 62 patients patient NNS cord-029547-9ei1ram3 375 63 with with IN cord-029547-9ei1ram3 375 64 Coronavirus-19 Coronavirus-19 NNP cord-029547-9ei1ram3 375 65 infection infection NN cord-029547-9ei1ram3 375 66 Clinical clinical JJ cord-029547-9ei1ram3 375 67 features feature NNS cord-029547-9ei1ram3 375 68 and and CC cord-029547-9ei1ram3 375 69 treatment treatment NN cord-029547-9ei1ram3 375 70 of of IN cord-029547-9ei1ram3 375 71 COVID-19 covid-19 JJ cord-029547-9ei1ram3 375 72 patients patient NNS cord-029547-9ei1ram3 375 73 in in IN cord-029547-9ei1ram3 375 74 northeast northeast JJ cord-029547-9ei1ram3 375 75 Chongqing Chongqing NNP cord-029547-9ei1ram3 375 76 Traditional traditional JJ cord-029547-9ei1ram3 375 77 Chinese chinese JJ cord-029547-9ei1ram3 375 78 medicine medicine NN cord-029547-9ei1ram3 375 79 for for IN cord-029547-9ei1ram3 375 80 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 375 81 treatment treatment NN cord-029547-9ei1ram3 375 82 Clinical clinical JJ cord-029547-9ei1ram3 375 83 characteristics characteristic NNS cord-029547-9ei1ram3 375 84 and and CC cord-029547-9ei1ram3 375 85 therapeutic therapeutic JJ cord-029547-9ei1ram3 375 86 procedure procedure NN cord-029547-9ei1ram3 375 87 for for IN cord-029547-9ei1ram3 375 88 four four CD cord-029547-9ei1ram3 375 89 cases case NNS cord-029547-9ei1ram3 375 90 with with IN cord-029547-9ei1ram3 375 91 2019 2019 CD cord-029547-9ei1ram3 375 92 novel novel JJ cord-029547-9ei1ram3 375 93 coronavirus coronavirus NN cord-029547-9ei1ram3 375 94 pneumonia pneumonia NN cord-029547-9ei1ram3 375 95 receiving receive VBG cord-029547-9ei1ram3 375 96 combined combine VBN cord-029547-9ei1ram3 375 97 Chinese chinese JJ cord-029547-9ei1ram3 375 98 and and CC cord-029547-9ei1ram3 375 99 Western western JJ cord-029547-9ei1ram3 375 100 medicine medicine NN cord-029547-9ei1ram3 375 101 treatment treatment NN cord-029547-9ei1ram3 376 1 The the DT cord-029547-9ei1ram3 376 2 potential potential JJ cord-029547-9ei1ram3 376 3 chemical chemical NN cord-029547-9ei1ram3 376 4 structure structure NN cord-029547-9ei1ram3 376 5 of of IN cord-029547-9ei1ram3 376 6 anti anti JJ cord-029547-9ei1ram3 376 7 - - JJ cord-029547-9ei1ram3 376 8 SARS SARS NNP cord-029547-9ei1ram3 376 9 - - HYPH cord-029547-9ei1ram3 376 10 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 376 11 RNA RNA NNP cord-029547-9ei1ram3 376 12 - - HYPH cord-029547-9ei1ram3 376 13 dependent dependent JJ cord-029547-9ei1ram3 376 14 RNA RNA NNP cord-029547-9ei1ram3 376 15 polymerase polymerase NN cord-029547-9ei1ram3 377 1 Lianhuaqingwen Lianhuaqingwen NNP cord-029547-9ei1ram3 377 2 exerts exert VBZ cord-029547-9ei1ram3 377 3 anti anti JJ cord-029547-9ei1ram3 377 4 - - JJ cord-029547-9ei1ram3 377 5 viral viral JJ cord-029547-9ei1ram3 377 6 and and CC cord-029547-9ei1ram3 377 7 anti anti JJ cord-029547-9ei1ram3 377 8 - - JJ cord-029547-9ei1ram3 377 9 inflammatory inflammatory JJ cord-029547-9ei1ram3 377 10 activity activity NN cord-029547-9ei1ram3 377 11 against against IN cord-029547-9ei1ram3 377 12 novel novel JJ cord-029547-9ei1ram3 377 13 coronavirus coronavirus NN cord-029547-9ei1ram3 377 14 ( ( -LRB- cord-029547-9ei1ram3 377 15 SARS SARS NNP cord-029547-9ei1ram3 377 16 - - HYPH cord-029547-9ei1ram3 377 17 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 377 18 ) ) -RRB- cord-029547-9ei1ram3 378 1 Geographical geographical JJ cord-029547-9ei1ram3 378 2 tracking tracking NN cord-029547-9ei1ram3 378 3 and and CC cord-029547-9ei1ram3 378 4 mapping mapping NN cord-029547-9ei1ram3 378 5 of of IN cord-029547-9ei1ram3 378 6 coronavirus coronavirus NN cord-029547-9ei1ram3 378 7 disease disease NN cord-029547-9ei1ram3 379 1 COVID-19 covid-19 JJ cord-029547-9ei1ram3 379 2 / / SYM cord-029547-9ei1ram3 379 3 severe severe JJ cord-029547-9ei1ram3 379 4 acute acute JJ cord-029547-9ei1ram3 379 5 respiratory respiratory JJ cord-029547-9ei1ram3 379 6 syndrome syndrome NN cord-029547-9ei1ram3 379 7 coronavirus coronavirus NN cord-029547-9ei1ram3 379 8 2 2 CD cord-029547-9ei1ram3 380 1 ( ( -LRB- cord-029547-9ei1ram3 380 2 SARS SARS NNP cord-029547-9ei1ram3 380 3 - - HYPH cord-029547-9ei1ram3 380 4 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 380 5 ) ) -RRB- cord-029547-9ei1ram3 380 6 epidemic epidemic NN cord-029547-9ei1ram3 380 7 and and CC cord-029547-9ei1ram3 380 8 associated associate VBD cord-029547-9ei1ram3 380 9 events event NNS cord-029547-9ei1ram3 380 10 around around IN cord-029547-9ei1ram3 380 11 the the DT cord-029547-9ei1ram3 380 12 world world NN cord-029547-9ei1ram3 380 13 : : : cord-029547-9ei1ram3 381 1 how how WRB cord-029547-9ei1ram3 381 2 21st 21st JJ cord-029547-9ei1ram3 381 3 century century NN cord-029547-9ei1ram3 381 4 GIS GIS NNP cord-029547-9ei1ram3 381 5 technologies technology NNS cord-029547-9ei1ram3 381 6 are be VBP cord-029547-9ei1ram3 381 7 supporting support VBG cord-029547-9ei1ram3 381 8 the the DT cord-029547-9ei1ram3 381 9 global global JJ cord-029547-9ei1ram3 381 10 fight fight NN cord-029547-9ei1ram3 381 11 against against IN cord-029547-9ei1ram3 381 12 outbreaks outbreak NNS cord-029547-9ei1ram3 381 13 and and CC cord-029547-9ei1ram3 381 14 epidemics epidemic NNS cord-029547-9ei1ram3 382 1 Positive positive JJ cord-029547-9ei1ram3 382 2 RT RT NNP cord-029547-9ei1ram3 382 3 - - HYPH cord-029547-9ei1ram3 382 4 PCR PCR NNP cord-029547-9ei1ram3 382 5 test test NN cord-029547-9ei1ram3 382 6 results result NNS cord-029547-9ei1ram3 382 7 in in IN cord-029547-9ei1ram3 382 8 patients patient NNS cord-029547-9ei1ram3 382 9 recovered recover VBN cord-029547-9ei1ram3 382 10 from from IN cord-029547-9ei1ram3 382 11 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 382 12 Training Training NNP cord-029547-9ei1ram3 382 13 and and CC cord-029547-9ei1ram3 382 14 fit fit JJ cord-029547-9ei1ram3 382 15 testing testing NN cord-029547-9ei1ram3 382 16 of of IN cord-029547-9ei1ram3 382 17 health health NN cord-029547-9ei1ram3 382 18 care care NN cord-029547-9ei1ram3 382 19 personnel personnel NNS cord-029547-9ei1ram3 382 20 for for IN cord-029547-9ei1ram3 382 21 reusable reusable JJ cord-029547-9ei1ram3 382 22 elastomeric elastomeric JJ cord-029547-9ei1ram3 382 23 half half JJ cord-029547-9ei1ram3 382 24 - - HYPH cord-029547-9ei1ram3 382 25 mask mask NN cord-029547-9ei1ram3 382 26 respirators respirator NNS cord-029547-9ei1ram3 382 27 compared compare VBN cord-029547-9ei1ram3 382 28 with with IN cord-029547-9ei1ram3 382 29 disposable disposable JJ cord-029547-9ei1ram3 382 30 N95 N95 NNP cord-029547-9ei1ram3 382 31 respirators respirator NNS cord-029547-9ei1ram3 382 32 A a DT cord-029547-9ei1ram3 382 33 sequence sequence NN cord-029547-9ei1ram3 382 34 homology homology NN cord-029547-9ei1ram3 382 35 and and CC cord-029547-9ei1ram3 382 36 bioinformatic bioinformatic JJ cord-029547-9ei1ram3 382 37 approach approach NN cord-029547-9ei1ram3 382 38 can can MD cord-029547-9ei1ram3 382 39 predict predict VB cord-029547-9ei1ram3 382 40 candidate candidate NN cord-029547-9ei1ram3 382 41 targets target NNS cord-029547-9ei1ram3 382 42 for for IN cord-029547-9ei1ram3 382 43 immune immune JJ cord-029547-9ei1ram3 382 44 responses response NNS cord-029547-9ei1ram3 382 45 to to IN cord-029547-9ei1ram3 382 46 SARS SARS NNP cord-029547-9ei1ram3 382 47 - - HYPH cord-029547-9ei1ram3 382 48 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 382 49 Structure Structure NNP cord-029547-9ei1ram3 382 50 , , , cord-029547-9ei1ram3 382 51 function function NN cord-029547-9ei1ram3 382 52 , , , cord-029547-9ei1ram3 382 53 and and CC cord-029547-9ei1ram3 382 54 antigenicity antigenicity NN cord-029547-9ei1ram3 382 55 of of IN cord-029547-9ei1ram3 382 56 the the DT cord-029547-9ei1ram3 382 57 SARS SARS NNP cord-029547-9ei1ram3 382 58 - - HYPH cord-029547-9ei1ram3 382 59 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 382 60 spike spike NN cord-029547-9ei1ram3 382 61 glycoprotein glycoprotein NN cord-029547-9ei1ram3 382 62 Potential potential JJ cord-029547-9ei1ram3 382 63 rapid rapid JJ cord-029547-9ei1ram3 382 64 diagnostics diagnostic NNS cord-029547-9ei1ram3 382 65 , , , cord-029547-9ei1ram3 382 66 vaccine vaccine NN cord-029547-9ei1ram3 382 67 and and CC cord-029547-9ei1ram3 382 68 therapeutics therapeutic NNS cord-029547-9ei1ram3 382 69 for for IN cord-029547-9ei1ram3 382 70 2019 2019 CD cord-029547-9ei1ram3 382 71 novel novel JJ cord-029547-9ei1ram3 382 72 coronavirus coronavirus NN cord-029547-9ei1ram3 382 73 ( ( -LRB- cord-029547-9ei1ram3 382 74 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 382 75 ) ) -RRB- cord-029547-9ei1ram3 382 76 : : : cord-029547-9ei1ram3 382 77 a a DT cord-029547-9ei1ram3 382 78 systematic systematic JJ cord-029547-9ei1ram3 382 79 review review NN cord-029547-9ei1ram3 382 80 Preliminary preliminary JJ cord-029547-9ei1ram3 382 81 identification identification NN cord-029547-9ei1ram3 382 82 of of IN cord-029547-9ei1ram3 382 83 potential potential JJ cord-029547-9ei1ram3 382 84 vaccine vaccine NN cord-029547-9ei1ram3 382 85 targets target NNS cord-029547-9ei1ram3 382 86 for for IN cord-029547-9ei1ram3 382 87 the the DT cord-029547-9ei1ram3 382 88 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 382 89 coronavirus coronavirus NN cord-029547-9ei1ram3 382 90 ( ( -LRB- cord-029547-9ei1ram3 382 91 SARS SARS NNP cord-029547-9ei1ram3 382 92 - - HYPH cord-029547-9ei1ram3 382 93 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 382 94 ) ) -RRB- cord-029547-9ei1ram3 383 1 based base VBN cord-029547-9ei1ram3 383 2 on on IN cord-029547-9ei1ram3 383 3 SARS SARS NNP cord-029547-9ei1ram3 383 4 - - HYPH cord-029547-9ei1ram3 383 5 CoV CoV NNP cord-029547-9ei1ram3 383 6 immunological immunological JJ cord-029547-9ei1ram3 383 7 studies study NNS cord-029547-9ei1ram3 383 8 Roadmap Roadmap NNP cord-029547-9ei1ram3 383 9 to to IN cord-029547-9ei1ram3 383 10 developing develop VBG cord-029547-9ei1ram3 383 11 a a DT cord-029547-9ei1ram3 383 12 recombinant recombinant JJ cord-029547-9ei1ram3 383 13 coronavirus coronavirus NN cord-029547-9ei1ram3 383 14 S s NN cord-029547-9ei1ram3 383 15 protein protein NN cord-029547-9ei1ram3 383 16 receptor receptor NN cord-029547-9ei1ram3 383 17 - - HYPH cord-029547-9ei1ram3 383 18 binding bind VBG cord-029547-9ei1ram3 383 19 domain domain NN cord-029547-9ei1ram3 383 20 vaccine vaccine NN cord-029547-9ei1ram3 383 21 for for IN cord-029547-9ei1ram3 383 22 severe severe JJ cord-029547-9ei1ram3 383 23 acute acute JJ cord-029547-9ei1ram3 383 24 respiratory respiratory JJ cord-029547-9ei1ram3 383 25 syndrome syndrome NN cord-029547-9ei1ram3 383 26 Henan Henan NNP cord-029547-9ei1ram3 383 27 Provincial Provincial NNP cord-029547-9ei1ram3 383 28 Center Center NNP cord-029547-9ei1ram3 383 29 for for IN cord-029547-9ei1ram3 383 30 Disease Disease NNP cord-029547-9ei1ram3 383 31 Control Control NNP cord-029547-9ei1ram3 383 32 and and CC cord-029547-9ei1ram3 383 33 Prevention Prevention NNP cord-029547-9ei1ram3 383 34 . . . cord-029547-9ei1ram3 384 1 A a DT cord-029547-9ei1ram3 384 2 randomized randomized JJ cord-029547-9ei1ram3 384 3 , , , cord-029547-9ei1ram3 384 4 double double JJ cord-029547-9ei1ram3 384 5 - - HYPH cord-029547-9ei1ram3 384 6 blind blind JJ cord-029547-9ei1ram3 384 7 , , , cord-029547-9ei1ram3 384 8 placebo placebo NN cord-029547-9ei1ram3 384 9 parallel parallel NN cord-029547-9ei1ram3 384 10 - - HYPH cord-029547-9ei1ram3 384 11 controlled control VBN cord-029547-9ei1ram3 384 12 phase phase NN cord-029547-9ei1ram3 384 13 I I NNP cord-029547-9ei1ram3 384 14 / / SYM cord-029547-9ei1ram3 384 15 II II NNP cord-029547-9ei1ram3 384 16 clinical clinical JJ cord-029547-9ei1ram3 384 17 trial trial NN cord-029547-9ei1ram3 384 18 for for IN cord-029547-9ei1ram3 384 19 inactivated inactivate VBN cord-029547-9ei1ram3 384 20 Novel Novel NNP cord-029547-9ei1ram3 384 21 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 384 22 Pneumonia Pneumonia NNP cord-029547-9ei1ram3 384 23 vaccine vaccine NN cord-029547-9ei1ram3 384 24 ( ( -LRB- cord-029547-9ei1ram3 384 25 Vero Vero NNP cord-029547-9ei1ram3 384 26 cells cell NNS cord-029547-9ei1ram3 384 27 Safety Safety NNP cord-029547-9ei1ram3 384 28 and and CC cord-029547-9ei1ram3 384 29 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 384 30 Study Study NNP cord-029547-9ei1ram3 384 31 of of IN cord-029547-9ei1ram3 384 32 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 384 33 Vaccine vaccine NN cord-029547-9ei1ram3 384 34 ( ( -LRB- cord-029547-9ei1ram3 384 35 Inactivated inactivate VBN cord-029547-9ei1ram3 384 36 ) ) -RRB- cord-029547-9ei1ram3 384 37 for for IN cord-029547-9ei1ram3 384 38 Prophylaxis Prophylaxis NNP cord-029547-9ei1ram3 384 39 SARS SARS NNP cord-029547-9ei1ram3 384 40 CoV CoV NNP cord-029547-9ei1ram3 385 1 NCT04352608?term nct04352608?term NN cord-029547-9ei1ram3 385 2 = = NFP cord-029547-9ei1ram3 386 1 vaccine&cond vaccine&cond NN cord-029547-9ei1ram3 386 2 = = NFP cord-029547-9ei1ram3 387 1 COVID-19&draw covid-19&draw NN cord-029547-9ei1ram3 387 2 = = NFP cord-029547-9ei1ram3 388 1 2&rank 2&rank LS cord-029547-9ei1ram3 388 2 = = NFP cord-029547-9ei1ram3 389 1 Henan Henan NNP cord-029547-9ei1ram3 389 2 Provincial Provincial NNP cord-029547-9ei1ram3 389 3 Center Center NNP cord-029547-9ei1ram3 389 4 for for IN cord-029547-9ei1ram3 389 5 Disease Disease NNP cord-029547-9ei1ram3 389 6 Control Control NNP cord-029547-9ei1ram3 389 7 and and CC cord-029547-9ei1ram3 389 8 Prevention Prevention NNP cord-029547-9ei1ram3 389 9 . . . cord-029547-9ei1ram3 390 1 A a DT cord-029547-9ei1ram3 390 2 phase phase NN cord-029547-9ei1ram3 390 3 I -PRON- PRP cord-029547-9ei1ram3 390 4 / / SYM cord-029547-9ei1ram3 390 5 II II NNP cord-029547-9ei1ram3 390 6 clinical clinical JJ cord-029547-9ei1ram3 390 7 trial trial NN cord-029547-9ei1ram3 390 8 for for IN cord-029547-9ei1ram3 390 9 inactivated inactivate VBN cord-029547-9ei1ram3 390 10 novel novel JJ cord-029547-9ei1ram3 390 11 coronavirus coronavirus NN cord-029547-9ei1ram3 390 12 ( ( -LRB- cord-029547-9ei1ram3 390 13 2019-CoV 2019-cov CD cord-029547-9ei1ram3 390 14 ) ) -RRB- cord-029547-9ei1ram3 390 15 vaccine vaccine NN cord-029547-9ei1ram3 390 16 ( ( -LRB- cord-029547-9ei1ram3 390 17 Vero Vero NNP cord-029547-9ei1ram3 390 18 cells cell NNS cord-029547-9ei1ram3 390 19 Study Study NNP cord-029547-9ei1ram3 390 20 to to TO cord-029547-9ei1ram3 390 21 Describe describe VB cord-029547-9ei1ram3 390 22 the the DT cord-029547-9ei1ram3 390 23 Safety Safety NNP cord-029547-9ei1ram3 390 24 , , , cord-029547-9ei1ram3 390 25 Tolerability Tolerability NNP cord-029547-9ei1ram3 390 26 , , , cord-029547-9ei1ram3 390 27 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 390 28 , , , cord-029547-9ei1ram3 390 29 and and CC cord-029547-9ei1ram3 390 30 Potential Potential NNP cord-029547-9ei1ram3 390 31 Efficacy Efficacy NNP cord-029547-9ei1ram3 390 32 of of IN cord-029547-9ei1ram3 390 33 RNA RNA NNP cord-029547-9ei1ram3 390 34 Vaccine Vaccine NNP cord-029547-9ei1ram3 390 35 Candidates Candidates NNPS cord-029547-9ei1ram3 390 36 Against against IN cord-029547-9ei1ram3 390 37 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 390 38 in in IN cord-029547-9ei1ram3 390 39 Healthy Healthy NNP cord-029547-9ei1ram3 390 40 Adults Adults NNPS cord-029547-9ei1ram3 391 1 Tolerability Tolerability NNP cord-029547-9ei1ram3 391 2 and and CC cord-029547-9ei1ram3 391 3 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 391 4 of of IN cord-029547-9ei1ram3 391 5 INO-4800 INO-4800 NNP cord-029547-9ei1ram3 391 6 for for IN cord-029547-9ei1ram3 391 7 COVID-19 covid-19 CD cord-029547-9ei1ram3 391 8 in in IN cord-029547-9ei1ram3 391 9 Healthy Healthy NNP cord-029547-9ei1ram3 391 10 Volunteers Volunteers NNP cord-029547-9ei1ram3 391 11 Safety Safety NNP cord-029547-9ei1ram3 391 12 and and CC cord-029547-9ei1ram3 391 13 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 391 14 Study Study NNP cord-029547-9ei1ram3 391 15 of of IN cord-029547-9ei1ram3 391 16 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 391 17 Vaccine vaccine NN cord-029547-9ei1ram3 391 18 ( ( -LRB- cord-029547-9ei1ram3 391 19 mRNA-1273 mrna-1273 XX cord-029547-9ei1ram3 391 20 ) ) -RRB- cord-029547-9ei1ram3 391 21 for for IN cord-029547-9ei1ram3 391 22 Prophylaxis Prophylaxis NNP cord-029547-9ei1ram3 391 23 SARS SARS NNP cord-029547-9ei1ram3 391 24 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 391 25 Infection Infection NNP cord-029547-9ei1ram3 391 26 ( ( -LRB- cord-029547-9ei1ram3 391 27 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 391 28 ) ) -RRB- cord-029547-9ei1ram3 392 1 Evaluating evaluate VBG cord-029547-9ei1ram3 392 2 the the DT cord-029547-9ei1ram3 392 3 Safety Safety NNP cord-029547-9ei1ram3 392 4 , , , cord-029547-9ei1ram3 392 5 Tolerability Tolerability NNP cord-029547-9ei1ram3 392 6 and and CC cord-029547-9ei1ram3 392 7 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 392 8 of of IN cord-029547-9ei1ram3 392 9 bacTRL bactrl NN cord-029547-9ei1ram3 392 10 - - HYPH cord-029547-9ei1ram3 392 11 Spike Spike NNP cord-029547-9ei1ram3 392 12 Vaccine Vaccine NNP cord-029547-9ei1ram3 392 13 for for IN cord-029547-9ei1ram3 392 14 Prevention Prevention NNP cord-029547-9ei1ram3 392 15 of of IN cord-029547-9ei1ram3 392 16 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 392 17 Vaccines Vaccines NNPS cord-029547-9ei1ram3 392 18 / / SYM cord-029547-9ei1ram3 392 19 Vaxart Vaxart NNP cord-029547-9ei1ram3 392 20 - - HYPH cord-029547-9ei1ram3 392 21 Announces Announces NNP cord-029547-9ei1ram3 392 22 - - HYPH cord-029547-9ei1ram3 392 23 Initiation initiation NN cord-029547-9ei1ram3 392 24 - - HYPH cord-029547-9ei1ram3 392 25 of of IN cord-029547-9ei1ram3 392 26 - - HYPH cord-029547-9ei1ram3 392 27 Cor Cor NNP cord-029547-9ei1ram3 392 28 onavirus-Vaccine-Program.html onavirus-Vaccine-Program.html NNP cord-029547-9ei1ram3 392 29 , , , cord-029547-9ei1ram3 392 30 accessed access VBN cord-029547-9ei1ram3 392 31 date date NN cord-029547-9ei1ram3 392 32 Evaluation Evaluation NNP cord-029547-9ei1ram3 392 33 of of IN cord-029547-9ei1ram3 392 34 the the DT cord-029547-9ei1ram3 392 35 Safety Safety NNP cord-029547-9ei1ram3 392 36 and and CC cord-029547-9ei1ram3 392 37 Immunogenicity Immunogenicity NNP cord-029547-9ei1ram3 392 38 of of IN cord-029547-9ei1ram3 392 39 a a DT cord-029547-9ei1ram3 392 40 SARS SARS NNP cord-029547-9ei1ram3 392 41 - - HYPH cord-029547-9ei1ram3 392 42 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 392 43 rS rS . cord-029547-9ei1ram3 393 1 ( ( -LRB- cord-029547-9ei1ram3 393 2 COVID-19 covid-19 VB cord-029547-9ei1ram3 393 3 ) ) -RRB- cord-029547-9ei1ram3 393 4 Nanoparticle Nanoparticle NNP cord-029547-9ei1ram3 393 5 Vaccine Vaccine NNP cord-029547-9ei1ram3 393 6 With with IN cord-029547-9ei1ram3 393 7 / / , cord-029547-9ei1ram3 393 8 Without without IN cord-029547-9ei1ram3 393 9 Matrix Matrix NNP cord-029547-9ei1ram3 393 10 - - HYPH cord-029547-9ei1ram3 393 11 M M NNP cord-029547-9ei1ram3 393 12 Adjuvant Adjuvant NNP cord-029547-9ei1ram3 394 1 CT04313127?term CT04313127?term NNP cord-029547-9ei1ram3 394 2 = = SYM cord-029547-9ei1ram3 394 3 vaccine&cond vaccine&cond NN cord-029547-9ei1ram3 394 4 = = SYM cord-029547-9ei1ram3 394 5 COVID-19&draw covid-19&draw NN cord-029547-9ei1ram3 394 6 = = NFP cord-029547-9ei1ram3 395 1 1&r 1&r CD cord-029547-9ei1ram3 395 2 ank ank NNP cord-029547-9ei1ram3 395 3 = = SYM cord-029547-9ei1ram3 395 4 8 8 CD cord-029547-9ei1ram3 395 5 , , , cord-029547-9ei1ram3 395 6 accessed access VBN cord-029547-9ei1ram3 395 7 date date NN cord-029547-9ei1ram3 395 8 Academy Academy NNP cord-029547-9ei1ram3 395 9 of of IN cord-029547-9ei1ram3 395 10 Military Military NNP cord-029547-9ei1ram3 395 11 Medical Medical NNP cord-029547-9ei1ram3 395 12 Sciences Sciences NNPS cord-029547-9ei1ram3 395 13 , , , cord-029547-9ei1ram3 395 14 PLA PLA NNP cord-029547-9ei1ram3 395 15 of of IN cord-029547-9ei1ram3 395 16 China China NNP cord-029547-9ei1ram3 395 17 . . . cord-029547-9ei1ram3 396 1 A a DT cord-029547-9ei1ram3 396 2 Phase Phase NNP cord-029547-9ei1ram3 396 3 II II NNP cord-029547-9ei1ram3 396 4 Clinical Clinical NNP cord-029547-9ei1ram3 396 5 Trial Trial NNP cord-029547-9ei1ram3 396 6 to to TO cord-029547-9ei1ram3 396 7 Evaluate evaluate VB cord-029547-9ei1ram3 396 8 the the DT cord-029547-9ei1ram3 396 9 Recombinant Recombinant NNP cord-029547-9ei1ram3 396 10 Novel Novel NNP cord-029547-9ei1ram3 396 11 Coronavirus Coronavirus NNP cord-029547-9ei1ram3 396 12 Vaccine Vaccine NNP cord-029547-9ei1ram3 396 13 ( ( -LRB- cord-029547-9ei1ram3 396 14 Adenovirus Adenovirus NNP cord-029547-9ei1ram3 396 15 Vector Vector NNP cord-029547-9ei1ram3 396 16 ) ) -RRB- cord-029547-9ei1ram3 397 1 ( ( -LRB- cord-029547-9ei1ram3 397 2 CTII ctii NN cord-029547-9ei1ram3 397 3 - - HYPH cord-029547-9ei1ram3 397 4 nCoV nCoV NNP cord-029547-9ei1ram3 397 5 Immune Immune NNP cord-029547-9ei1ram3 397 6 Medical Medical NNP cord-029547-9ei1ram3 397 7 Institute Institute NNP cord-029547-9ei1ram3 397 8 . . . cord-029547-9ei1ram3 398 1 Safety safety NN cord-029547-9ei1ram3 398 2 and and CC cord-029547-9ei1ram3 398 3 Immunity Immunity NNP cord-029547-9ei1ram3 398 4 of of IN cord-029547-9ei1ram3 398 5 Covid-19 covid-19 JJ cord-029547-9ei1ram3 398 6 aAPC aAPC NNP cord-029547-9ei1ram3 398 7 Vaccine Vaccine NNP cord-029547-9ei1ram3 398 8 Immunity Immunity NNP cord-029547-9ei1ram3 398 9 and and CC cord-029547-9ei1ram3 398 10 Safety Safety NNP cord-029547-9ei1ram3 398 11 of of IN cord-029547-9ei1ram3 398 12 Covid-19 Covid-19 NNP cord-029547-9ei1ram3 398 13 Synthetic Synthetic NNP cord-029547-9ei1ram3 398 14 Minigene Minigene NNP cord-029547-9ei1ram3 398 15 Vaccine Vaccine NNP cord-029547-9ei1ram3 398 16 Covid-19 covid-19 NN cord-029547-9ei1ram3 398 17 : : : cord-029547-9ei1ram3 398 18 four four CD cord-029547-9ei1ram3 398 19 fifths fifth NNS cord-029547-9ei1ram3 398 20 of of IN cord-029547-9ei1ram3 398 21 cases case NNS cord-029547-9ei1ram3 398 22 are be VBP cord-029547-9ei1ram3 398 23 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 398 24 , , , cord-029547-9ei1ram3 398 25 China China NNP cord-029547-9ei1ram3 398 26 figures figure NNS cord-029547-9ei1ram3 398 27 indicate indicate VBP cord-029547-9ei1ram3 398 28 Presumed presume VBN cord-029547-9ei1ram3 398 29 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 398 30 carrier carrier NN cord-029547-9ei1ram3 398 31 transmission transmission NN cord-029547-9ei1ram3 398 32 of of IN cord-029547-9ei1ram3 398 33 COVID-19 COVID-19 NNP cord-029547-9ei1ram3 398 34 Transmission Transmission NNP cord-029547-9ei1ram3 398 35 of of IN cord-029547-9ei1ram3 398 36 2019-nCoV 2019-ncov CD cord-029547-9ei1ram3 398 37 infection infection NN cord-029547-9ei1ram3 398 38 from from IN cord-029547-9ei1ram3 398 39 an an DT cord-029547-9ei1ram3 398 40 asymptomatic asymptomatic JJ cord-029547-9ei1ram3 398 41 contact contact NN cord-029547-9ei1ram3 398 42 in in IN cord-029547-9ei1ram3 398 43 Germany Germany NNP cord-029547-9ei1ram3 398 44 Evidence Evidence NNP cord-029547-9ei1ram3 398 45 of of IN cord-029547-9ei1ram3 398 46 SARS SARS NNP cord-029547-9ei1ram3 398 47 - - HYPH cord-029547-9ei1ram3 398 48 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 398 49 infection infection NN cord-029547-9ei1ram3 398 50 in in IN cord-029547-9ei1ram3 398 51 returning return VBG cord-029547-9ei1ram3 398 52 travelers traveler NNS cord-029547-9ei1ram3 398 53 from from IN cord-029547-9ei1ram3 398 54 Wuhan Wuhan NNP cord-029547-9ei1ram3 398 55 , , , cord-029547-9ei1ram3 398 56 China China NNP cord-029547-9ei1ram3 398 57 Virological Virological NNP cord-029547-9ei1ram3 398 58 assessment assessment NN cord-029547-9ei1ram3 398 59 of of IN cord-029547-9ei1ram3 398 60 hospitalized hospitalize VBN cord-029547-9ei1ram3 398 61 patients patient NNS cord-029547-9ei1ram3 398 62 with with IN cord-029547-9ei1ram3 398 63 COVID-2019 COVID-2019 NNP cord-029547-9ei1ram3 398 64 Respiratory respiratory JJ cord-029547-9ei1ram3 398 65 disease disease NN cord-029547-9ei1ram3 398 66 in in IN cord-029547-9ei1ram3 398 67 rhesus rhesus NN cord-029547-9ei1ram3 398 68 macaques macaque NNS cord-029547-9ei1ram3 398 69 inoculated inoculate VBN cord-029547-9ei1ram3 398 70 with with IN cord-029547-9ei1ram3 398 71 SARS SARS NNP cord-029547-9ei1ram3 398 72 - - HYPH cord-029547-9ei1ram3 398 73 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 398 74 SARS SARS NNP cord-029547-9ei1ram3 398 75 - - HYPH cord-029547-9ei1ram3 398 76 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 398 77 receptor receptor NN cord-029547-9ei1ram3 398 78 ACE2 ACE2 NNP cord-029547-9ei1ram3 398 79 is be VBZ cord-029547-9ei1ram3 398 80 an an DT cord-029547-9ei1ram3 398 81 interferon interferon NN cord-029547-9ei1ram3 398 82 - - HYPH cord-029547-9ei1ram3 398 83 stimulated stimulate VBN cord-029547-9ei1ram3 398 84 gene gene NN cord-029547-9ei1ram3 398 85 in in IN cord-029547-9ei1ram3 398 86 human human JJ cord-029547-9ei1ram3 398 87 airway airway NN cord-029547-9ei1ram3 398 88 epithelial epithelial JJ cord-029547-9ei1ram3 398 89 cells cell NNS cord-029547-9ei1ram3 398 90 and and CC cord-029547-9ei1ram3 398 91 is be VBZ cord-029547-9ei1ram3 398 92 detected detect VBN cord-029547-9ei1ram3 398 93 in in IN cord-029547-9ei1ram3 398 94 specific specific JJ cord-029547-9ei1ram3 398 95 cell cell NN cord-029547-9ei1ram3 398 96 subsets subset NNS cord-029547-9ei1ram3 398 97 across across IN cord-029547-9ei1ram3 398 98 tissues tissue NNS cord-029547-9ei1ram3 399 1 The the DT cord-029547-9ei1ram3 399 2 pathogenicity pathogenicity NN cord-029547-9ei1ram3 399 3 of of IN cord-029547-9ei1ram3 399 4 SARS SARS NNP cord-029547-9ei1ram3 399 5 - - HYPH cord-029547-9ei1ram3 399 6 CoV-2 CoV-2 NNP cord-029547-9ei1ram3 399 7 in in IN cord-029547-9ei1ram3 399 8 hACE2 hace2 NN cord-029547-9ei1ram3 399 9 transgenic transgenic JJ cord-029547-9ei1ram3 399 10 mice mouse NNS cord-029547-9ei1ram3 400 1 This this DT cord-029547-9ei1ram3 400 2 work work NN cord-029547-9ei1ram3 400 3 was be VBD cord-029547-9ei1ram3 400 4 supported support VBN cord-029547-9ei1ram3 400 5 by by IN cord-029547-9ei1ram3 400 6 the the DT cord-029547-9ei1ram3 400 7 National National NNP cord-029547-9ei1ram3 400 8 Natural Natural NNP cord-029547-9ei1ram3 400 9 Science Science NNP cord-029547-9ei1ram3 400 10 _SP cord-029547-9ei1ram3 401 1 All all DT cord-029547-9ei1ram3 401 2 authors author NNS cord-029547-9ei1ram3 401 3 declared declare VBD cord-029547-9ei1ram3 401 4 that that IN cord-029547-9ei1ram3 401 5 they -PRON- PRP cord-029547-9ei1ram3 401 6 had have VBD cord-029547-9ei1ram3 401 7 no no DT cord-029547-9ei1ram3 401 8 conflict conflict NN cord-029547-9ei1ram3 401 9 of of IN cord-029547-9ei1ram3 401 10 interest interest NN cord-029547-9ei1ram3 401 11 . . .