id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274668-lh7c9izt	Wang, Chaofu	Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients	2020-06-20		.txt	text/plain	4584	253	45	BACKGROUND: The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatal organ failure. INTERPRETATION: Infection of Alveolar macrophage by SARS-CoV-2 might be drivers of the "cytokine storm", which might result in damages in pulmonary tissues, heart and lung, and leading to the failure of multiple organs . One case report showed the pathological characteristics of a patient who died from severe infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by postmortem biopsies. Moreover, type II alveolar epithelial cells and macrophages in alveoli and pulmonary hilum lymphoid tissue were infected by SARS-CoV-2, as revealed by immunohistochemistry using Rp3-NP specific antibodies (Figs. [10] In the case of COVID-19, the viral infection of aggregated alveolar macrophages was obvious from early phase to the late stage, according to our study and the results in recent reports of pulmonary pathology [17, 20] .	./cache/cord-274668-lh7c9izt.txt	./txt/cord-274668-lh7c9izt.txt