id sid tid token lemma pos cord-021894-lq8yr710 1 1 key key NN cord-021894-lq8yr710 1 2 : : : cord-021894-lq8yr710 1 3 cord-021894-lq8yr710 cord-021894-lq8yr710 NNS cord-021894-lq8yr710 1 4 authors author NNS cord-021894-lq8yr710 1 5 : : : cord-021894-lq8yr710 1 6 Cunningham Cunningham NNP cord-021894-lq8yr710 1 7 , , , cord-021894-lq8yr710 1 8 Steve Steve NNP cord-021894-lq8yr710 1 9 title title NN cord-021894-lq8yr710 1 10 : : : cord-021894-lq8yr710 1 11 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 1 12 date date NN cord-021894-lq8yr710 1 13 : : : cord-021894-lq8yr710 1 14 2018 2018 CD cord-021894-lq8yr710 1 15 - - HYPH cord-021894-lq8yr710 1 16 03 03 CD cord-021894-lq8yr710 1 17 - - SYM cord-021894-lq8yr710 1 18 13 13 CD cord-021894-lq8yr710 1 19 journal journal NN cord-021894-lq8yr710 1 20 : : : cord-021894-lq8yr710 2 1 Kendig Kendig NNP cord-021894-lq8yr710 2 2 's 's POS cord-021894-lq8yr710 2 3 Disorders Disorders NNPS cord-021894-lq8yr710 2 4 of of IN cord-021894-lq8yr710 2 5 the the DT cord-021894-lq8yr710 2 6 Respiratory respiratory JJ cord-021894-lq8yr710 2 7 Tract tract NN cord-021894-lq8yr710 2 8 in in IN cord-021894-lq8yr710 2 9 Children Children NNP cord-021894-lq8yr710 2 10 DOI DOI NNP cord-021894-lq8yr710 2 11 : : : cord-021894-lq8yr710 3 1 10.1016 10.1016 CD cord-021894-lq8yr710 3 2 / / SYM cord-021894-lq8yr710 3 3 b978 b978 NNP cord-021894-lq8yr710 3 4 - - HYPH cord-021894-lq8yr710 3 5 0 0 CD cord-021894-lq8yr710 3 6 - - HYPH cord-021894-lq8yr710 3 7 323 323 CD cord-021894-lq8yr710 3 8 - - HYPH cord-021894-lq8yr710 3 9 44887- 44887- NNP cord-021894-lq8yr710 4 1 1.00024 1.00024 CD cord-021894-lq8yr710 4 2 - - SYM cord-021894-lq8yr710 4 3 9 9 CD cord-021894-lq8yr710 4 4 sha sha NN cord-021894-lq8yr710 4 5 : : : cord-021894-lq8yr710 4 6 5d5018dc9287a58f4aabd9b9e7617ab572acc62c 5d5018dc9287a58f4aabd9b9e7617ab572acc62c CD cord-021894-lq8yr710 4 7 doc_id doc_id CD cord-021894-lq8yr710 4 8 : : : cord-021894-lq8yr710 4 9 21894 21894 CD cord-021894-lq8yr710 4 10 cord_uid cord_uid NNS cord-021894-lq8yr710 4 11 : : : cord-021894-lq8yr710 5 1 lq8yr710 lq8yr710 NNP cord-021894-lq8yr710 5 2 Acute acute JJ cord-021894-lq8yr710 5 3 viral viral JJ cord-021894-lq8yr710 5 4 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 5 5 is be VBZ cord-021894-lq8yr710 5 6 a a DT cord-021894-lq8yr710 5 7 common common JJ cord-021894-lq8yr710 5 8 viral viral JJ cord-021894-lq8yr710 5 9 lower low JJR cord-021894-lq8yr710 5 10 respiratory respiratory JJ cord-021894-lq8yr710 5 11 tract tract NN cord-021894-lq8yr710 5 12 infection infection NN cord-021894-lq8yr710 5 13 in in IN cord-021894-lq8yr710 5 14 young young JJ cord-021894-lq8yr710 5 15 children child NNS cord-021894-lq8yr710 5 16 . . . cord-021894-lq8yr710 6 1 Most most RBS cord-021894-lq8yr710 6 2 typically typically RB cord-021894-lq8yr710 6 3 caused cause VBN cord-021894-lq8yr710 6 4 by by IN cord-021894-lq8yr710 6 5 respiratory respiratory JJ cord-021894-lq8yr710 6 6 syncytial syncytial JJ cord-021894-lq8yr710 6 7 virus virus NN cord-021894-lq8yr710 6 8 in in IN cord-021894-lq8yr710 6 9 70 70 CD cord-021894-lq8yr710 6 10 % % NN cord-021894-lq8yr710 6 11 of of IN cord-021894-lq8yr710 6 12 cases case NNS cord-021894-lq8yr710 6 13 , , , cord-021894-lq8yr710 6 14 the the DT cord-021894-lq8yr710 6 15 condition condition NN cord-021894-lq8yr710 6 16 lasts last VBZ cord-021894-lq8yr710 6 17 for for IN cord-021894-lq8yr710 6 18 4 4 CD cord-021894-lq8yr710 6 19 to to TO cord-021894-lq8yr710 6 20 7 7 CD cord-021894-lq8yr710 6 21 days day NNS cord-021894-lq8yr710 6 22 , , , cord-021894-lq8yr710 6 23 with with IN cord-021894-lq8yr710 6 24 a a DT cord-021894-lq8yr710 6 25 prolonged prolonged JJ cord-021894-lq8yr710 6 26 cough cough NN cord-021894-lq8yr710 6 27 in in IN cord-021894-lq8yr710 6 28 many many JJ cord-021894-lq8yr710 6 29 . . . cord-021894-lq8yr710 7 1 Children child NNS cord-021894-lq8yr710 7 2 with with IN cord-021894-lq8yr710 7 3 comorbidity comorbidity NN cord-021894-lq8yr710 7 4 , , , cord-021894-lq8yr710 7 5 particularly particularly RB cord-021894-lq8yr710 7 6 those those DT cord-021894-lq8yr710 7 7 born bear VBN cord-021894-lq8yr710 7 8 prematurely prematurely RB cord-021894-lq8yr710 7 9 or or CC cord-021894-lq8yr710 7 10 with with IN cord-021894-lq8yr710 7 11 significant significant JJ cord-021894-lq8yr710 7 12 congenital congenital JJ cord-021894-lq8yr710 7 13 heart heart NN cord-021894-lq8yr710 7 14 disease disease NN cord-021894-lq8yr710 7 15 , , , cord-021894-lq8yr710 7 16 are be VBP cord-021894-lq8yr710 7 17 at at IN cord-021894-lq8yr710 7 18 risk risk NN cord-021894-lq8yr710 7 19 of of IN cord-021894-lq8yr710 7 20 more more RBR cord-021894-lq8yr710 7 21 severe severe JJ cord-021894-lq8yr710 7 22 disease disease NN cord-021894-lq8yr710 7 23 . . . cord-021894-lq8yr710 8 1 Nasal nasal JJ cord-021894-lq8yr710 8 2 obstruction obstruction NN cord-021894-lq8yr710 8 3 progresses progress VBZ cord-021894-lq8yr710 8 4 over over IN cord-021894-lq8yr710 8 5 3 3 CD cord-021894-lq8yr710 8 6 to to TO cord-021894-lq8yr710 8 7 4 4 CD cord-021894-lq8yr710 8 8 days day NNS cord-021894-lq8yr710 8 9 to to IN cord-021894-lq8yr710 8 10 difficulty difficulty VB cord-021894-lq8yr710 8 11 with with IN cord-021894-lq8yr710 8 12 feeding feeding NN cord-021894-lq8yr710 8 13 and and CC cord-021894-lq8yr710 8 14 increased increase VBN cord-021894-lq8yr710 8 15 work work NN cord-021894-lq8yr710 8 16 of of IN cord-021894-lq8yr710 8 17 breathing breathe VBG cord-021894-lq8yr710 8 18 with with IN cord-021894-lq8yr710 8 19 hypoxemia hypoxemia NN cord-021894-lq8yr710 8 20 . . . cord-021894-lq8yr710 9 1 Crackles crackle NNS cord-021894-lq8yr710 9 2 and/or and/or CC cord-021894-lq8yr710 9 3 wheeze wheeze NN cord-021894-lq8yr710 9 4 may may MD cord-021894-lq8yr710 9 5 be be VB cord-021894-lq8yr710 9 6 auscultated auscultate VBN cord-021894-lq8yr710 9 7 . . . cord-021894-lq8yr710 10 1 Apnoea Apnoea NNP cord-021894-lq8yr710 10 2 may may MD cord-021894-lq8yr710 10 3 be be VB cord-021894-lq8yr710 10 4 a a DT cord-021894-lq8yr710 10 5 presenting present VBG cord-021894-lq8yr710 10 6 sign sign NN cord-021894-lq8yr710 10 7 in in IN cord-021894-lq8yr710 10 8 those those DT cord-021894-lq8yr710 10 9 less less JJR cord-021894-lq8yr710 10 10 than than IN cord-021894-lq8yr710 10 11 3 3 CD cord-021894-lq8yr710 10 12 months month NNS cord-021894-lq8yr710 10 13 of of IN cord-021894-lq8yr710 10 14 age age NN cord-021894-lq8yr710 10 15 . . . cord-021894-lq8yr710 11 1 Viral viral JJ cord-021894-lq8yr710 11 2 load load NN cord-021894-lq8yr710 11 3 is be VBZ cord-021894-lq8yr710 11 4 highest high JJS cord-021894-lq8yr710 11 5 at at IN cord-021894-lq8yr710 11 6 peak peak NN cord-021894-lq8yr710 11 7 of of IN cord-021894-lq8yr710 11 8 symptoms symptom NNS cord-021894-lq8yr710 11 9 and and CC cord-021894-lq8yr710 11 10 in in IN cord-021894-lq8yr710 11 11 those those DT cord-021894-lq8yr710 11 12 with with IN cord-021894-lq8yr710 11 13 more more RBR cord-021894-lq8yr710 11 14 severe severe JJ cord-021894-lq8yr710 11 15 disease disease NN cord-021894-lq8yr710 11 16 . . . cord-021894-lq8yr710 12 1 Approximately approximately RB cord-021894-lq8yr710 12 2 2 2 CD cord-021894-lq8yr710 12 3 % % NN cord-021894-lq8yr710 12 4 to to TO cord-021894-lq8yr710 12 5 3 3 CD cord-021894-lq8yr710 12 6 % % NN cord-021894-lq8yr710 12 7 of of IN cord-021894-lq8yr710 12 8 all all DT cord-021894-lq8yr710 12 9 children child NNS cord-021894-lq8yr710 12 10 are be VBP cord-021894-lq8yr710 12 11 admitted admit VBN cord-021894-lq8yr710 12 12 to to IN cord-021894-lq8yr710 12 13 hospital hospital NN cord-021894-lq8yr710 12 14 with with IN cord-021894-lq8yr710 12 15 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 12 16 . . . cord-021894-lq8yr710 13 1 The the DT cord-021894-lq8yr710 13 2 differential differential JJ cord-021894-lq8yr710 13 3 diagnosis diagnosis NN cord-021894-lq8yr710 13 4 may may MD cord-021894-lq8yr710 13 5 include include VB cord-021894-lq8yr710 13 6 bacterial bacterial JJ cord-021894-lq8yr710 13 7 pneumonia pneumonia NN cord-021894-lq8yr710 13 8 , , , cord-021894-lq8yr710 13 9 congenital congenital JJ cord-021894-lq8yr710 13 10 lesions lesion NNS cord-021894-lq8yr710 13 11 of of IN cord-021894-lq8yr710 13 12 the the DT cord-021894-lq8yr710 13 13 lung lung NN cord-021894-lq8yr710 13 14 or or CC cord-021894-lq8yr710 13 15 heart heart NN cord-021894-lq8yr710 13 16 , , , cord-021894-lq8yr710 13 17 or or CC cord-021894-lq8yr710 13 18 an an DT cord-021894-lq8yr710 13 19 interstitial interstitial JJ cord-021894-lq8yr710 13 20 lung lung NN cord-021894-lq8yr710 13 21 disease disease NN cord-021894-lq8yr710 13 22 . . . cord-021894-lq8yr710 14 1 There there EX cord-021894-lq8yr710 14 2 are be VBP cord-021894-lq8yr710 14 3 no no DT cord-021894-lq8yr710 14 4 effective effective JJ cord-021894-lq8yr710 14 5 treatments treatment NNS cord-021894-lq8yr710 14 6 , , , cord-021894-lq8yr710 14 7 and and CC cord-021894-lq8yr710 14 8 admission admission NN cord-021894-lq8yr710 14 9 is be VBZ cord-021894-lq8yr710 14 10 for for IN cord-021894-lq8yr710 14 11 feeding feed VBG cord-021894-lq8yr710 14 12 support support NN cord-021894-lq8yr710 14 13 ( ( -LRB- cord-021894-lq8yr710 14 14 by by IN cord-021894-lq8yr710 14 15 nasogastric nasogastric NN cord-021894-lq8yr710 14 16 or or CC cord-021894-lq8yr710 14 17 intravenous intravenous JJ cord-021894-lq8yr710 14 18 fluids fluid NNS cord-021894-lq8yr710 14 19 ) ) -RRB- cord-021894-lq8yr710 14 20 or or CC cord-021894-lq8yr710 14 21 treatment treatment NN cord-021894-lq8yr710 14 22 of of IN cord-021894-lq8yr710 14 23 hypoxemia hypoxemia NN cord-021894-lq8yr710 14 24 . . . cord-021894-lq8yr710 15 1 Critical critical JJ cord-021894-lq8yr710 15 2 care care NN cord-021894-lq8yr710 15 3 support support NN cord-021894-lq8yr710 15 4 is be VBZ cord-021894-lq8yr710 15 5 required require VBN cord-021894-lq8yr710 15 6 for for IN cord-021894-lq8yr710 15 7 some some DT cord-021894-lq8yr710 15 8 infants infant NNS cord-021894-lq8yr710 15 9 experiencing experience VBG cord-021894-lq8yr710 15 10 respiratory respiratory JJ cord-021894-lq8yr710 15 11 failure failure NN cord-021894-lq8yr710 15 12 , , , cord-021894-lq8yr710 15 13 though though IN cord-021894-lq8yr710 15 14 mortality mortality NN cord-021894-lq8yr710 15 15 rates rate NNS cord-021894-lq8yr710 15 16 remain remain VBP cord-021894-lq8yr710 15 17 unchanged unchanged JJ cord-021894-lq8yr710 15 18 . . . cord-021894-lq8yr710 16 1 Practice practice VB cord-021894-lq8yr710 16 2 within within IN cord-021894-lq8yr710 16 3 and and CC cord-021894-lq8yr710 16 4 between between IN cord-021894-lq8yr710 16 5 countries country NNS cord-021894-lq8yr710 16 6 varies vary VBZ cord-021894-lq8yr710 16 7 significantly significantly RB cord-021894-lq8yr710 16 8 and and CC cord-021894-lq8yr710 16 9 alignment alignment NN cord-021894-lq8yr710 16 10 of of IN cord-021894-lq8yr710 16 11 practice practice NN cord-021894-lq8yr710 16 12 is be VBZ cord-021894-lq8yr710 16 13 a a DT cord-021894-lq8yr710 16 14 common common JJ cord-021894-lq8yr710 16 15 goal goal NN cord-021894-lq8yr710 16 16 of of IN cord-021894-lq8yr710 16 17 guidelines guideline NNS cord-021894-lq8yr710 16 18 . . . cord-021894-lq8yr710 17 1 Vaccines vaccine NNS cord-021894-lq8yr710 17 2 for for IN cord-021894-lq8yr710 17 3 RSV RSV NNP cord-021894-lq8yr710 17 4 are be VBP cord-021894-lq8yr710 17 5 in in IN cord-021894-lq8yr710 17 6 advanced advanced JJ cord-021894-lq8yr710 17 7 development development NN cord-021894-lq8yr710 17 8 , , , cord-021894-lq8yr710 17 9 as as IN cord-021894-lq8yr710 17 10 are be VBP cord-021894-lq8yr710 17 11 several several JJ cord-021894-lq8yr710 17 12 antiviral antiviral JJ cord-021894-lq8yr710 17 13 therapies therapy NNS cord-021894-lq8yr710 17 14 for for IN cord-021894-lq8yr710 17 15 RSV RSV NNP cord-021894-lq8yr710 17 16 . . . cord-021894-lq8yr710 18 1 In in IN cord-021894-lq8yr710 18 2 most most JJS cord-021894-lq8yr710 18 3 children child NNS cord-021894-lq8yr710 18 4 , , , cord-021894-lq8yr710 18 5 acute acute JJ cord-021894-lq8yr710 18 6 symptoms symptom NNS cord-021894-lq8yr710 18 7 improve improve VBP cord-021894-lq8yr710 18 8 within within IN cord-021894-lq8yr710 18 9 5 5 CD cord-021894-lq8yr710 18 10 to to TO cord-021894-lq8yr710 18 11 7 7 CD cord-021894-lq8yr710 18 12 days day NNS cord-021894-lq8yr710 18 13 and and CC cord-021894-lq8yr710 18 14 cough cough NN cord-021894-lq8yr710 18 15 by by IN cord-021894-lq8yr710 18 16 2 2 CD cord-021894-lq8yr710 18 17 weeks week NNS cord-021894-lq8yr710 18 18 . . . cord-021894-lq8yr710 19 1 Recurrent recurrent JJ cord-021894-lq8yr710 19 2 wheeze wheeze NN cord-021894-lq8yr710 19 3 is be VBZ cord-021894-lq8yr710 19 4 common common JJ cord-021894-lq8yr710 19 5 following follow VBG cord-021894-lq8yr710 19 6 acute acute JJ cord-021894-lq8yr710 19 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 19 8 and and CC cord-021894-lq8yr710 19 9 a a DT cord-021894-lq8yr710 19 10 good good JJ cord-021894-lq8yr710 19 11 association association NN cord-021894-lq8yr710 19 12 with with IN cord-021894-lq8yr710 19 13 a a DT cord-021894-lq8yr710 19 14 diagnosis diagnosis NN cord-021894-lq8yr710 19 15 of of IN cord-021894-lq8yr710 19 16 asthma asthma NN cord-021894-lq8yr710 19 17 in in IN cord-021894-lq8yr710 19 18 childhood childhood NN cord-021894-lq8yr710 19 19 . . . cord-021894-lq8yr710 20 1 RSV RSV NNP cord-021894-lq8yr710 20 2 infects infect VBZ cord-021894-lq8yr710 20 3 69 69 CD cord-021894-lq8yr710 20 4 % % NN cord-021894-lq8yr710 20 5 to to TO cord-021894-lq8yr710 20 6 98 98 CD cord-021894-lq8yr710 20 7 % % NN cord-021894-lq8yr710 20 8 of of IN cord-021894-lq8yr710 20 9 infants infant NNS cord-021894-lq8yr710 20 10 in in IN cord-021894-lq8yr710 20 11 the the DT cord-021894-lq8yr710 20 12 first first JJ cord-021894-lq8yr710 20 13 year year NN cord-021894-lq8yr710 20 14 of of IN cord-021894-lq8yr710 20 15 life life NN cord-021894-lq8yr710 20 16 . . . cord-021894-lq8yr710 21 1 18 18 CD cord-021894-lq8yr710 21 2 , , , cord-021894-lq8yr710 21 3 19 19 CD cord-021894-lq8yr710 22 1 The the DT cord-021894-lq8yr710 22 2 rapid rapid JJ cord-021894-lq8yr710 22 3 development development NN cord-021894-lq8yr710 22 4 of of IN cord-021894-lq8yr710 22 5 vaccines vaccine NNS cord-021894-lq8yr710 22 6 and and CC cord-021894-lq8yr710 22 7 treatment treatment NN cord-021894-lq8yr710 22 8 therapies therapy NNS cord-021894-lq8yr710 22 9 for for IN cord-021894-lq8yr710 22 10 RSV RSV NNP cord-021894-lq8yr710 22 11 has have VBZ cord-021894-lq8yr710 22 12 added add VBN cord-021894-lq8yr710 22 13 impetus impetus NN cord-021894-lq8yr710 22 14 to to IN cord-021894-lq8yr710 22 15 the the DT cord-021894-lq8yr710 22 16 need need NN cord-021894-lq8yr710 22 17 to to TO cord-021894-lq8yr710 22 18 better better RB cord-021894-lq8yr710 22 19 define define VB cord-021894-lq8yr710 22 20 the the DT cord-021894-lq8yr710 22 21 burden burden NN cord-021894-lq8yr710 22 22 of of IN cord-021894-lq8yr710 22 23 RSV RSV NNP cord-021894-lq8yr710 22 24 disease disease NN cord-021894-lq8yr710 22 25 . . . cord-021894-lq8yr710 23 1 Globally globally RB cord-021894-lq8yr710 23 2 there there EX cord-021894-lq8yr710 23 3 are be VBP cord-021894-lq8yr710 23 4 an an DT cord-021894-lq8yr710 23 5 estimated estimate VBN cord-021894-lq8yr710 23 6 33.8 33.8 CD cord-021894-lq8yr710 23 7 million million CD cord-021894-lq8yr710 23 8 cases case NNS cord-021894-lq8yr710 23 9 of of IN cord-021894-lq8yr710 23 10 RSV RSV NNP cord-021894-lq8yr710 23 11 lower low JJR cord-021894-lq8yr710 23 12 respiratory respiratory JJ cord-021894-lq8yr710 23 13 tract tract NN cord-021894-lq8yr710 23 14 infection infection NN cord-021894-lq8yr710 23 15 each each DT cord-021894-lq8yr710 23 16 year year NN cord-021894-lq8yr710 23 17 in in IN cord-021894-lq8yr710 23 18 children child NNS cord-021894-lq8yr710 23 19 under under IN cord-021894-lq8yr710 23 20 5 5 CD cord-021894-lq8yr710 23 21 years year NNS cord-021894-lq8yr710 23 22 of of IN cord-021894-lq8yr710 23 23 age age NN cord-021894-lq8yr710 23 24 , , , cord-021894-lq8yr710 23 25 resulting result VBG cord-021894-lq8yr710 23 26 in in IN cord-021894-lq8yr710 23 27 3.4 3.4 CD cord-021894-lq8yr710 23 28 million million CD cord-021894-lq8yr710 23 29 admissions admission NNS cord-021894-lq8yr710 23 30 to to IN cord-021894-lq8yr710 23 31 the the DT cord-021894-lq8yr710 23 32 hospital hospital NN cord-021894-lq8yr710 23 33 and and CC cord-021894-lq8yr710 23 34 66 66 CD cord-021894-lq8yr710 23 35 to to TO cord-021894-lq8yr710 23 36 199 199 CD cord-021894-lq8yr710 23 37 thousand thousand CD cord-021894-lq8yr710 23 38 deaths death NNS cord-021894-lq8yr710 23 39 ( ( -LRB- cord-021894-lq8yr710 23 40 with with IN cord-021894-lq8yr710 23 41 the the DT cord-021894-lq8yr710 23 42 majority majority NN cord-021894-lq8yr710 23 43 in in IN cord-021894-lq8yr710 23 44 low low JJ cord-021894-lq8yr710 23 45 - - HYPH cord-021894-lq8yr710 23 46 and and CC cord-021894-lq8yr710 23 47 middle middle JJ cord-021894-lq8yr710 23 48 - - HYPH cord-021894-lq8yr710 23 49 income income NN cord-021894-lq8yr710 23 50 countries country NNS cord-021894-lq8yr710 23 51 ) ) -RRB- cord-021894-lq8yr710 23 52 . . . cord-021894-lq8yr710 24 1 20 20 CD cord-021894-lq8yr710 25 1 In in IN cord-021894-lq8yr710 25 2 the the DT cord-021894-lq8yr710 25 3 United United NNP cord-021894-lq8yr710 25 4 States States NNP cord-021894-lq8yr710 25 5 an an DT cord-021894-lq8yr710 25 6 estimated estimate VBN cord-021894-lq8yr710 25 7 20 20 CD cord-021894-lq8yr710 25 8 % % NN cord-021894-lq8yr710 25 9 of of IN cord-021894-lq8yr710 25 10 children child NNS cord-021894-lq8yr710 25 11 will will MD cord-021894-lq8yr710 25 12 attend attend VB cord-021894-lq8yr710 25 13 primary primary JJ cord-021894-lq8yr710 25 14 care care NN cord-021894-lq8yr710 25 15 each each DT cord-021894-lq8yr710 25 16 year year NN cord-021894-lq8yr710 25 17 with with IN cord-021894-lq8yr710 25 18 RSV RSV NNP cord-021894-lq8yr710 25 19 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 25 20 , , , cord-021894-lq8yr710 25 21 and and CC cord-021894-lq8yr710 25 22 up up IN cord-021894-lq8yr710 25 23 to to TO cord-021894-lq8yr710 25 24 7 7 CD cord-021894-lq8yr710 25 25 % % NN cord-021894-lq8yr710 25 26 attend attend VBP cord-021894-lq8yr710 25 27 an an DT cord-021894-lq8yr710 25 28 Emergency Emergency NNP cord-021894-lq8yr710 25 29 Department Department NNP cord-021894-lq8yr710 25 30 ( ( -LRB- cord-021894-lq8yr710 25 31 ED ED NNP cord-021894-lq8yr710 25 32 ) ) -RRB- cord-021894-lq8yr710 25 33 . . . cord-021894-lq8yr710 26 1 21 21 CD cord-021894-lq8yr710 26 2 Admission admission NN cord-021894-lq8yr710 26 3 to to IN cord-021894-lq8yr710 26 4 hospital hospital NN cord-021894-lq8yr710 26 5 with with IN cord-021894-lq8yr710 26 6 RSV RSV NNP cord-021894-lq8yr710 26 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 26 8 is be VBZ cord-021894-lq8yr710 26 9 typically typically RB cord-021894-lq8yr710 26 10 around around IN cord-021894-lq8yr710 26 11 2.4 2.4 CD cord-021894-lq8yr710 26 12 % % NN cord-021894-lq8yr710 26 13 of of IN cord-021894-lq8yr710 26 14 all all DT cord-021894-lq8yr710 26 15 infants infant NNS cord-021894-lq8yr710 26 16 , , , cord-021894-lq8yr710 26 17 15 15 CD cord-021894-lq8yr710 26 18 , , , cord-021894-lq8yr710 26 19 22 22 CD cord-021894-lq8yr710 26 20 though though RB cord-021894-lq8yr710 26 21 in in IN cord-021894-lq8yr710 26 22 previously previously RB cord-021894-lq8yr710 26 23 healthy healthy JJ cord-021894-lq8yr710 26 24 term term NN cord-021894-lq8yr710 26 25 infants infant NNS cord-021894-lq8yr710 26 26 , , , cord-021894-lq8yr710 26 27 the the DT cord-021894-lq8yr710 26 28 admission admission NN cord-021894-lq8yr710 26 29 rate rate NN cord-021894-lq8yr710 26 30 to to IN cord-021894-lq8yr710 26 31 hospital hospital NN cord-021894-lq8yr710 26 32 with with IN cord-021894-lq8yr710 26 33 RSV RSV NNP cord-021894-lq8yr710 26 34 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 26 35 can can MD cord-021894-lq8yr710 26 36 be be VB cord-021894-lq8yr710 26 37 as as RB cord-021894-lq8yr710 26 38 low low JJ cord-021894-lq8yr710 26 39 as as IN cord-021894-lq8yr710 26 40 0.7 0.7 CD cord-021894-lq8yr710 26 41 % % NN cord-021894-lq8yr710 26 42 . . . cord-021894-lq8yr710 27 1 23 23 CD cord-021894-lq8yr710 27 2 _SP cord-021894-lq8yr710 28 1 In in IN cord-021894-lq8yr710 28 2 infants infant NNS cord-021894-lq8yr710 28 3 who who WP cord-021894-lq8yr710 28 4 are be VBP cord-021894-lq8yr710 28 5 born bear VBN cord-021894-lq8yr710 28 6 preterm preterm NNS cord-021894-lq8yr710 28 7 at at IN cord-021894-lq8yr710 28 8 32 32 CD cord-021894-lq8yr710 28 9 to to TO cord-021894-lq8yr710 28 10 35 35 CD cord-021894-lq8yr710 28 11 weeks week NNS cord-021894-lq8yr710 28 12 ' ' POS cord-021894-lq8yr710 28 13 gestation gestation NN cord-021894-lq8yr710 28 14 , , , cord-021894-lq8yr710 28 15 48 48 CD cord-021894-lq8yr710 28 16 % % NN cord-021894-lq8yr710 28 17 will will MD cord-021894-lq8yr710 28 18 develop develop VB cord-021894-lq8yr710 28 19 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 28 20 and and CC cord-021894-lq8yr710 28 21 6 6 CD cord-021894-lq8yr710 28 22 % % NN cord-021894-lq8yr710 28 23 require require VBP cord-021894-lq8yr710 28 24 admission admission NN cord-021894-lq8yr710 28 25 to to IN cord-021894-lq8yr710 28 26 the the DT cord-021894-lq8yr710 28 27 hospital hospital NN cord-021894-lq8yr710 28 28 . . . cord-021894-lq8yr710 29 1 24 24 CD cord-021894-lq8yr710 30 1 The the DT cord-021894-lq8yr710 30 2 risk risk NN cord-021894-lq8yr710 30 3 of of IN cord-021894-lq8yr710 30 4 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 30 5 is be VBZ cord-021894-lq8yr710 30 6 increased increase VBN cord-021894-lq8yr710 30 7 in in IN cord-021894-lq8yr710 30 8 a a DT cord-021894-lq8yr710 30 9 range range NN cord-021894-lq8yr710 30 10 of of IN cord-021894-lq8yr710 30 11 conditions condition NNS cord-021894-lq8yr710 30 12 compared compare VBN cord-021894-lq8yr710 30 13 with with IN cord-021894-lq8yr710 30 14 term term NN cord-021894-lq8yr710 30 15 infants infant NNS cord-021894-lq8yr710 30 16 , , , cord-021894-lq8yr710 30 17 including include VBG cord-021894-lq8yr710 30 18 preterm preterm JJR cord-021894-lq8yr710 30 19 birth birth NN cord-021894-lq8yr710 30 20 ( ( -LRB- cord-021894-lq8yr710 30 21 respiratory respiratory JJ cord-021894-lq8yr710 30 22 rate rate NN cord-021894-lq8yr710 30 23 [ [ -LRB- cord-021894-lq8yr710 30 24 RR rr NN cord-021894-lq8yr710 30 25 ] ] -RRB- cord-021894-lq8yr710 30 26 1 1 CD cord-021894-lq8yr710 30 27 . . . cord-021894-lq8yr710 30 28 89 89 CD cord-021894-lq8yr710 30 29 ) ) -RRB- cord-021894-lq8yr710 30 30 , , , cord-021894-lq8yr710 30 31 cystic cystic JJ cord-021894-lq8yr710 30 32 fibrosis fibrosis NN cord-021894-lq8yr710 30 33 ( ( -LRB- cord-021894-lq8yr710 30 34 RR RR NNP cord-021894-lq8yr710 30 35 2.45 2.45 CD cord-021894-lq8yr710 30 36 ) ) -RRB- cord-021894-lq8yr710 30 37 , , , cord-021894-lq8yr710 30 38 congenital congenital JJ cord-021894-lq8yr710 30 39 heart heart NN cord-021894-lq8yr710 30 40 disease disease NN cord-021894-lq8yr710 30 41 ( ( -LRB- cord-021894-lq8yr710 30 42 RR RR NNP cord-021894-lq8yr710 30 43 3.35 3.35 CD cord-021894-lq8yr710 30 44 ) ) -RRB- cord-021894-lq8yr710 30 45 , , , cord-021894-lq8yr710 30 46 chronic chronic JJ cord-021894-lq8yr710 30 47 lung lung NN cord-021894-lq8yr710 30 48 disease disease NN cord-021894-lq8yr710 30 49 ( ( -LRB- cord-021894-lq8yr710 30 50 RR RR NNP cord-021894-lq8yr710 30 51 1.61 1.61 CD cord-021894-lq8yr710 30 52 ) ) -RRB- cord-021894-lq8yr710 30 53 , , , cord-021894-lq8yr710 30 54 immunodeficiency immunodeficiency NN cord-021894-lq8yr710 30 55 ( ( -LRB- cord-021894-lq8yr710 30 56 RR RR NNP cord-021894-lq8yr710 30 57 1.73 1.73 CD cord-021894-lq8yr710 30 58 ) ) -RRB- cord-021894-lq8yr710 30 59 , , , cord-021894-lq8yr710 30 60 Down down IN cord-021894-lq8yr710 30 61 syndrome syndrome NN cord-021894-lq8yr710 30 62 ( ( -LRB- cord-021894-lq8yr710 30 63 RR RR NNP cord-021894-lq8yr710 30 64 2.53 2.53 CD cord-021894-lq8yr710 30 65 ) ) -RRB- cord-021894-lq8yr710 30 66 , , , cord-021894-lq8yr710 30 67 and and CC cord-021894-lq8yr710 30 68 cerebral cerebral JJ cord-021894-lq8yr710 30 69 palsy palsy NN cord-021894-lq8yr710 30 70 ( ( -LRB- cord-021894-lq8yr710 30 71 RR RR NNP cord-021894-lq8yr710 30 72 2.43 2.43 CD cord-021894-lq8yr710 30 73 ) ) -RRB- cord-021894-lq8yr710 30 74 . . . cord-021894-lq8yr710 31 1 25 25 CD cord-021894-lq8yr710 31 2 , , , cord-021894-lq8yr710 31 3 26 26 CD cord-021894-lq8yr710 31 4 Epidemiology Epidemiology NNP cord-021894-lq8yr710 31 5 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 31 6 is be VBZ cord-021894-lq8yr710 31 7 the the DT cord-021894-lq8yr710 31 8 most most RBS cord-021894-lq8yr710 31 9 common common JJ cord-021894-lq8yr710 31 10 lower low JJR cord-021894-lq8yr710 31 11 respiratory respiratory JJ cord-021894-lq8yr710 31 12 tract tract NN cord-021894-lq8yr710 31 13 infection infection NN cord-021894-lq8yr710 31 14 in in IN cord-021894-lq8yr710 31 15 children child NNS cord-021894-lq8yr710 31 16 . . . cord-021894-lq8yr710 32 1 The the DT cord-021894-lq8yr710 32 2 condition condition NN cord-021894-lq8yr710 32 3 forms form VBZ cord-021894-lq8yr710 32 4 part part NN cord-021894-lq8yr710 32 5 of of IN cord-021894-lq8yr710 32 6 the the DT cord-021894-lq8yr710 32 7 spectrum spectrum NN cord-021894-lq8yr710 32 8 of of IN cord-021894-lq8yr710 32 9 viral viral JJ cord-021894-lq8yr710 32 10 lower low JJR cord-021894-lq8yr710 32 11 respiratory respiratory JJ cord-021894-lq8yr710 32 12 tract tract NN cord-021894-lq8yr710 32 13 infection infection NN cord-021894-lq8yr710 32 14 that that WDT cord-021894-lq8yr710 32 15 includes include VBZ cord-021894-lq8yr710 32 16 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 32 17 , , , cord-021894-lq8yr710 32 18 viral viral JJ cord-021894-lq8yr710 32 19 pneumonia pneumonia NN cord-021894-lq8yr710 32 20 , , , cord-021894-lq8yr710 32 21 and and CC cord-021894-lq8yr710 32 22 viral viral RB cord-021894-lq8yr710 32 23 - - HYPH cord-021894-lq8yr710 32 24 induced induce VBN cord-021894-lq8yr710 32 25 wheeze wheeze NN cord-021894-lq8yr710 32 26 . . . cord-021894-lq8yr710 33 1 In in IN cord-021894-lq8yr710 33 2 polar polar JJ cord-021894-lq8yr710 33 3 hemispheres hemisphere NNS cord-021894-lq8yr710 33 4 ( ( -LRB- cord-021894-lq8yr710 33 5 north north NN cord-021894-lq8yr710 33 6 and and CC cord-021894-lq8yr710 33 7 south south NNP cord-021894-lq8yr710 33 8 ) ) -RRB- cord-021894-lq8yr710 33 9 , , , cord-021894-lq8yr710 33 10 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 33 11 is be VBZ cord-021894-lq8yr710 33 12 a a DT cord-021894-lq8yr710 33 13 seasonal seasonal JJ cord-021894-lq8yr710 33 14 disease disease NN cord-021894-lq8yr710 33 15 , , , cord-021894-lq8yr710 33 16 dominating dominate VBG cord-021894-lq8yr710 33 17 winter winter NN cord-021894-lq8yr710 33 18 months month NNS cord-021894-lq8yr710 33 19 , , , cord-021894-lq8yr710 33 20 with with IN cord-021894-lq8yr710 33 21 a a DT cord-021894-lq8yr710 33 22 peak peak NN cord-021894-lq8yr710 33 23 over over IN cord-021894-lq8yr710 33 24 6 6 CD cord-021894-lq8yr710 33 25 to to TO cord-021894-lq8yr710 33 26 8 8 CD cord-021894-lq8yr710 33 27 weeks week NNS cord-021894-lq8yr710 33 28 around around IN cord-021894-lq8yr710 33 29 the the DT cord-021894-lq8yr710 33 30 winter winter NN cord-021894-lq8yr710 33 31 solstice solstice NN cord-021894-lq8yr710 33 32 . . . cord-021894-lq8yr710 34 1 In in IN cord-021894-lq8yr710 34 2 tropical tropical JJ cord-021894-lq8yr710 34 3 climates climate NNS cord-021894-lq8yr710 34 4 , , , cord-021894-lq8yr710 34 5 the the DT cord-021894-lq8yr710 34 6 disease disease NN cord-021894-lq8yr710 34 7 is be VBZ cord-021894-lq8yr710 34 8 associated associate VBN cord-021894-lq8yr710 34 9 with with IN cord-021894-lq8yr710 34 10 rainy rainy JJ cord-021894-lq8yr710 34 11 months month NNS cord-021894-lq8yr710 34 12 and and CC cord-021894-lq8yr710 34 13 is be VBZ cord-021894-lq8yr710 34 14 seasonally seasonally RB cord-021894-lq8yr710 34 15 more more RBR cord-021894-lq8yr710 34 16 dispersed disperse VBN cord-021894-lq8yr710 34 17 . . . cord-021894-lq8yr710 35 1 1 1 LS cord-021894-lq8yr710 36 1 Climate climate NN cord-021894-lq8yr710 36 2 and and CC cord-021894-lq8yr710 36 3 environment environment NN cord-021894-lq8yr710 36 4 appear appear VBP cord-021894-lq8yr710 36 5 to to TO cord-021894-lq8yr710 36 6 influence influence VB cord-021894-lq8yr710 36 7 both both DT cord-021894-lq8yr710 36 8 season season NN cord-021894-lq8yr710 36 9 and and CC cord-021894-lq8yr710 36 10 severity severity NN cord-021894-lq8yr710 36 11 . . . cord-021894-lq8yr710 37 1 2 2 LS cord-021894-lq8yr710 37 2 , , , cord-021894-lq8yr710 37 3 3 3 CD cord-021894-lq8yr710 37 4 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 37 5 is be VBZ cord-021894-lq8yr710 37 6 diagnosed diagnose VBN cord-021894-lq8yr710 37 7 clinically clinically RB cord-021894-lq8yr710 37 8 by by IN cord-021894-lq8yr710 37 9 integrating integrate VBG cord-021894-lq8yr710 37 10 characteristic characteristic JJ cord-021894-lq8yr710 37 11 but but CC cord-021894-lq8yr710 37 12 variable variable JJ cord-021894-lq8yr710 37 13 signs sign NNS cord-021894-lq8yr710 37 14 and and CC cord-021894-lq8yr710 37 15 symptoms symptom NNS cord-021894-lq8yr710 37 16 across across IN cord-021894-lq8yr710 37 17 a a DT cord-021894-lq8yr710 37 18 broad broad JJ cord-021894-lq8yr710 37 19 age age NN cord-021894-lq8yr710 37 20 range range NN cord-021894-lq8yr710 37 21 , , , cord-021894-lq8yr710 37 22 though though IN cord-021894-lq8yr710 37 23 the the DT cord-021894-lq8yr710 37 24 majority majority NN cord-021894-lq8yr710 37 25 of of IN cord-021894-lq8yr710 37 26 cases case NNS cord-021894-lq8yr710 37 27 occur occur VBP cord-021894-lq8yr710 37 28 in in IN cord-021894-lq8yr710 37 29 children child NNS cord-021894-lq8yr710 37 30 under under IN cord-021894-lq8yr710 37 31 1 1 CD cord-021894-lq8yr710 37 32 year year NN cord-021894-lq8yr710 37 33 of of IN cord-021894-lq8yr710 37 34 age age NN cord-021894-lq8yr710 37 35 . . . cord-021894-lq8yr710 38 1 The the DT cord-021894-lq8yr710 38 2 condition condition NN cord-021894-lq8yr710 38 3 can can MD cord-021894-lq8yr710 38 4 be be VB cord-021894-lq8yr710 38 5 caused cause VBN cord-021894-lq8yr710 38 6 by by IN cord-021894-lq8yr710 38 7 any any DT cord-021894-lq8yr710 38 8 respiratory respiratory JJ cord-021894-lq8yr710 38 9 virus virus NN cord-021894-lq8yr710 38 10 and and CC cord-021894-lq8yr710 38 11 has have VBZ cord-021894-lq8yr710 38 12 a a DT cord-021894-lq8yr710 38 13 wide wide JJ cord-021894-lq8yr710 38 14 spectrum spectrum NN cord-021894-lq8yr710 38 15 of of IN cord-021894-lq8yr710 38 16 disease disease NN cord-021894-lq8yr710 38 17 severity severity NN cord-021894-lq8yr710 38 18 . . . cord-021894-lq8yr710 39 1 4 4 LS cord-021894-lq8yr710 39 2 A a DT cord-021894-lq8yr710 39 3 " " `` cord-021894-lq8yr710 39 4 classic classic JJ cord-021894-lq8yr710 39 5 " " '' cord-021894-lq8yr710 39 6 case case NN cord-021894-lq8yr710 39 7 would would MD cord-021894-lq8yr710 39 8 be be VB cord-021894-lq8yr710 39 9 an an DT cord-021894-lq8yr710 39 10 infant infant NN cord-021894-lq8yr710 39 11 aged age VBN cord-021894-lq8yr710 39 12 3 3 CD cord-021894-lq8yr710 39 13 to to TO cord-021894-lq8yr710 39 14 5 5 CD cord-021894-lq8yr710 39 15 months month NNS cord-021894-lq8yr710 39 16 of of IN cord-021894-lq8yr710 39 17 age age NN cord-021894-lq8yr710 39 18 5 5 CD cord-021894-lq8yr710 39 19 who who WP cord-021894-lq8yr710 39 20 develops develop VBZ cord-021894-lq8yr710 39 21 coryza coryza NNS cord-021894-lq8yr710 39 22 and and CC cord-021894-lq8yr710 39 23 over over IN cord-021894-lq8yr710 39 24 the the DT cord-021894-lq8yr710 39 25 subsequent subsequent JJ cord-021894-lq8yr710 39 26 3 3 CD cord-021894-lq8yr710 39 27 to to TO cord-021894-lq8yr710 39 28 4 4 CD cord-021894-lq8yr710 39 29 days day NNS cord-021894-lq8yr710 39 30 has have VBZ cord-021894-lq8yr710 39 31 increased increase VBN cord-021894-lq8yr710 39 32 difficulty difficulty NN cord-021894-lq8yr710 39 33 with with IN cord-021894-lq8yr710 39 34 breathing breathing NN cord-021894-lq8yr710 39 35 , , , cord-021894-lq8yr710 39 36 and and CC cord-021894-lq8yr710 39 37 consequent consequent JJ cord-021894-lq8yr710 39 38 inability inability NN cord-021894-lq8yr710 39 39 to to TO cord-021894-lq8yr710 39 40 maintain maintain VB cord-021894-lq8yr710 39 41 adequate adequate JJ cord-021894-lq8yr710 39 42 oral oral JJ cord-021894-lq8yr710 39 43 feeding feeding NN cord-021894-lq8yr710 39 44 . . . cord-021894-lq8yr710 40 1 Wheeze wheeze VB cord-021894-lq8yr710 40 2 or or CC cord-021894-lq8yr710 40 3 crackles crackle NNS cord-021894-lq8yr710 40 4 can can MD cord-021894-lq8yr710 40 5 be be VB cord-021894-lq8yr710 40 6 heard hear VBN cord-021894-lq8yr710 40 7 on on IN cord-021894-lq8yr710 40 8 auscultation auscultation NN cord-021894-lq8yr710 40 9 . . . cord-021894-lq8yr710 41 1 Improvement improvement NN cord-021894-lq8yr710 41 2 occurs occur VBZ cord-021894-lq8yr710 41 3 by by IN cord-021894-lq8yr710 41 4 days day NNS cord-021894-lq8yr710 41 5 5 5 CD cord-021894-lq8yr710 41 6 to to IN cord-021894-lq8yr710 41 7 7 7 CD cord-021894-lq8yr710 41 8 , , , cord-021894-lq8yr710 41 9 though though IN cord-021894-lq8yr710 41 10 a a DT cord-021894-lq8yr710 41 11 characteristic characteristic JJ cord-021894-lq8yr710 41 12 harsh harsh JJ cord-021894-lq8yr710 41 13 cough cough NN cord-021894-lq8yr710 41 14 may may MD cord-021894-lq8yr710 41 15 persist persist VB cord-021894-lq8yr710 41 16 for for IN cord-021894-lq8yr710 41 17 21 21 CD cord-021894-lq8yr710 41 18 days day NNS cord-021894-lq8yr710 41 19 or or CC cord-021894-lq8yr710 41 20 more more JJR cord-021894-lq8yr710 41 21 . . . cord-021894-lq8yr710 42 1 6 6 CD cord-021894-lq8yr710 42 2 , , , cord-021894-lq8yr710 42 3 7 7 CD cord-021894-lq8yr710 43 1 While while IN cord-021894-lq8yr710 43 2 the the DT cord-021894-lq8yr710 43 3 diagnosis diagnosis NN cord-021894-lq8yr710 43 4 often often RB cord-021894-lq8yr710 43 5 appears appear VBZ cord-021894-lq8yr710 43 6 straightforward straightforward JJ cord-021894-lq8yr710 43 7 , , , cord-021894-lq8yr710 43 8 the the DT cord-021894-lq8yr710 43 9 wide wide JJ cord-021894-lq8yr710 43 10 range range NN cord-021894-lq8yr710 43 11 of of IN cord-021894-lq8yr710 43 12 disease disease NN cord-021894-lq8yr710 43 13 severity severity NN cord-021894-lq8yr710 43 14 across across IN cord-021894-lq8yr710 43 15 a a DT cord-021894-lq8yr710 43 16 skewed skewed JJ cord-021894-lq8yr710 43 17 but but CC cord-021894-lq8yr710 43 18 broad broad JJ cord-021894-lq8yr710 43 19 age age NN cord-021894-lq8yr710 43 20 range range NN cord-021894-lq8yr710 43 21 and and CC cord-021894-lq8yr710 43 22 the the DT cord-021894-lq8yr710 43 23 need need NN cord-021894-lq8yr710 43 24 for for IN cord-021894-lq8yr710 43 25 clinical clinical JJ cord-021894-lq8yr710 43 26 diagnosis diagnosis NN cord-021894-lq8yr710 43 27 ( ( -LRB- cord-021894-lq8yr710 43 28 with with IN cord-021894-lq8yr710 43 29 associated associated JJ cord-021894-lq8yr710 43 30 inconsistency inconsistency NN cord-021894-lq8yr710 43 31 ) ) -RRB- cord-021894-lq8yr710 43 32 creates create VBZ cord-021894-lq8yr710 43 33 difficulty difficulty NN cord-021894-lq8yr710 43 34 in in IN cord-021894-lq8yr710 43 35 establishing establish VBG cord-021894-lq8yr710 43 36 precise precise JJ cord-021894-lq8yr710 43 37 data datum NNS cord-021894-lq8yr710 43 38 . . . cord-021894-lq8yr710 44 1 8 8 CD cord-021894-lq8yr710 45 1 In in IN cord-021894-lq8yr710 45 2 addition addition NN cord-021894-lq8yr710 45 3 , , , cord-021894-lq8yr710 45 4 while while IN cord-021894-lq8yr710 45 5 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 45 6 is be VBZ cord-021894-lq8yr710 45 7 a a DT cord-021894-lq8yr710 45 8 clinical clinical JJ cord-021894-lq8yr710 45 9 diagnosis diagnosis NN cord-021894-lq8yr710 45 10 applied apply VBN cord-021894-lq8yr710 45 11 to to IN cord-021894-lq8yr710 45 12 any any DT cord-021894-lq8yr710 45 13 infecting infect VBG cord-021894-lq8yr710 45 14 agent agent NN cord-021894-lq8yr710 45 15 , , , cord-021894-lq8yr710 45 16 the the DT cord-021894-lq8yr710 45 17 majority majority NN cord-021894-lq8yr710 45 18 of of IN cord-021894-lq8yr710 45 19 data datum NNS cord-021894-lq8yr710 45 20 available available JJ cord-021894-lq8yr710 45 21 relate relate VBP cord-021894-lq8yr710 45 22 to to IN cord-021894-lq8yr710 45 23 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 45 24 caused cause VBN cord-021894-lq8yr710 45 25 by by IN cord-021894-lq8yr710 45 26 respiratory respiratory JJ cord-021894-lq8yr710 45 27 syncytial syncytial JJ cord-021894-lq8yr710 45 28 virus virus NN cord-021894-lq8yr710 45 29 ( ( -LRB- cord-021894-lq8yr710 45 30 RSV RSV NNP cord-021894-lq8yr710 45 31 ) ) -RRB- cord-021894-lq8yr710 45 32 infection infection NN cord-021894-lq8yr710 45 33 ; ; : cord-021894-lq8yr710 45 34 and and CC cord-021894-lq8yr710 45 35 within within IN cord-021894-lq8yr710 45 36 RSV RSV NNP cord-021894-lq8yr710 45 37 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 45 38 is be VBZ cord-021894-lq8yr710 45 39 a a DT cord-021894-lq8yr710 45 40 focus focus NN cord-021894-lq8yr710 45 41 on on IN cord-021894-lq8yr710 45 42 those those DT cord-021894-lq8yr710 45 43 at at IN cord-021894-lq8yr710 45 44 high high JJ cord-021894-lq8yr710 45 45 risk risk NN cord-021894-lq8yr710 45 46 , , , cord-021894-lq8yr710 45 47 in in IN cord-021894-lq8yr710 45 48 particular particular JJ cord-021894-lq8yr710 45 49 , , , cord-021894-lq8yr710 45 50 those those DT cord-021894-lq8yr710 45 51 born bear VBN cord-021894-lq8yr710 45 52 prematurely prematurely RB cord-021894-lq8yr710 45 53 . . . cord-021894-lq8yr710 46 1 Reference reference NN cord-021894-lq8yr710 46 2 to to IN cord-021894-lq8yr710 46 3 these these DT cord-021894-lq8yr710 46 4 groups group NNS cord-021894-lq8yr710 46 5 synonymously synonymously RB cord-021894-lq8yr710 46 6 with with IN cord-021894-lq8yr710 46 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 46 8 can can MD cord-021894-lq8yr710 46 9 make make VB cord-021894-lq8yr710 46 10 interpretation interpretation NN cord-021894-lq8yr710 46 11 of of IN cord-021894-lq8yr710 46 12 epidemiological epidemiological JJ cord-021894-lq8yr710 46 13 data datum NNS cord-021894-lq8yr710 46 14 difficult difficult JJ cord-021894-lq8yr710 46 15 and and CC cord-021894-lq8yr710 46 16 may may MD cord-021894-lq8yr710 46 17 reduce reduce VB cord-021894-lq8yr710 46 18 the the DT cord-021894-lq8yr710 46 19 understanding understanding NN cord-021894-lq8yr710 46 20 of of IN cord-021894-lq8yr710 46 21 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 46 22 caused cause VBN cord-021894-lq8yr710 46 23 by by IN cord-021894-lq8yr710 46 24 non non JJ cord-021894-lq8yr710 46 25 - - JJ cord-021894-lq8yr710 46 26 RSV RSV NNP cord-021894-lq8yr710 46 27 and and CC cord-021894-lq8yr710 46 28 in in IN cord-021894-lq8yr710 46 29 lower low JJR cord-021894-lq8yr710 46 30 risk risk NN cord-021894-lq8yr710 46 31 patients patient NNS cord-021894-lq8yr710 46 32 ( ( -LRB- cord-021894-lq8yr710 46 33 particularly particularly RB cord-021894-lq8yr710 46 34 children child NNS cord-021894-lq8yr710 46 35 born bear VBN cord-021894-lq8yr710 46 36 at at IN cord-021894-lq8yr710 46 37 term term NN cord-021894-lq8yr710 46 38 ) ) -RRB- cord-021894-lq8yr710 46 39 . . . cord-021894-lq8yr710 47 1 There there EX cord-021894-lq8yr710 47 2 are be VBP cord-021894-lq8yr710 47 3 only only RB cord-021894-lq8yr710 47 4 limited limited JJ cord-021894-lq8yr710 47 5 estimates estimate NNS cord-021894-lq8yr710 47 6 of of IN cord-021894-lq8yr710 47 7 population population NN cord-021894-lq8yr710 47 8 risk risk NN cord-021894-lq8yr710 47 9 for for IN cord-021894-lq8yr710 47 10 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 47 11 associated associate VBN cord-021894-lq8yr710 47 12 with with IN cord-021894-lq8yr710 47 13 all all DT cord-021894-lq8yr710 47 14 respiratory respiratory JJ cord-021894-lq8yr710 47 15 virus virus NN cord-021894-lq8yr710 47 16 infections infection NNS cord-021894-lq8yr710 47 17 , , , cord-021894-lq8yr710 47 18 but but CC cord-021894-lq8yr710 47 19 approximately approximately RB cord-021894-lq8yr710 47 20 40 40 CD cord-021894-lq8yr710 47 21 % % NN cord-021894-lq8yr710 47 22 of of IN cord-021894-lq8yr710 47 23 infants infant NNS cord-021894-lq8yr710 47 24 are be VBP cord-021894-lq8yr710 47 25 affected affect VBN cord-021894-lq8yr710 47 26 by by IN cord-021894-lq8yr710 47 27 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 47 28 in in IN cord-021894-lq8yr710 47 29 the the DT cord-021894-lq8yr710 47 30 first first JJ cord-021894-lq8yr710 47 31 year year NN cord-021894-lq8yr710 47 32 of of IN cord-021894-lq8yr710 47 33 life life NN cord-021894-lq8yr710 47 34 . . . cord-021894-lq8yr710 48 1 9 9 CD cord-021894-lq8yr710 49 1 In in IN cord-021894-lq8yr710 49 2 the the DT cord-021894-lq8yr710 49 3 United United NNP cord-021894-lq8yr710 49 4 Kingdom Kingdom NNP cord-021894-lq8yr710 49 5 , , , cord-021894-lq8yr710 49 6 using use VBG cord-021894-lq8yr710 49 7 primary primary JJ cord-021894-lq8yr710 49 8 care care NN cord-021894-lq8yr710 49 9 databases database NNS cord-021894-lq8yr710 49 10 , , , cord-021894-lq8yr710 49 11 the the DT cord-021894-lq8yr710 49 12 1 1 CD cord-021894-lq8yr710 49 13 year year NN cord-021894-lq8yr710 49 14 incidence incidence NN cord-021894-lq8yr710 49 15 of of IN cord-021894-lq8yr710 49 16 children child NNS cord-021894-lq8yr710 49 17 given give VBN cord-021894-lq8yr710 49 18 a a DT cord-021894-lq8yr710 49 19 specific specific JJ cord-021894-lq8yr710 49 20 diagnosis diagnosis NN cord-021894-lq8yr710 49 21 of of IN cord-021894-lq8yr710 49 22 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 50 1 is be VBZ cord-021894-lq8yr710 50 2 58 58 CD cord-021894-lq8yr710 50 3 to to TO cord-021894-lq8yr710 50 4 65 65 CD cord-021894-lq8yr710 50 5 per per IN cord-021894-lq8yr710 50 6 1000 1000 CD cord-021894-lq8yr710 50 7 children child NNS cord-021894-lq8yr710 50 8 , , , cord-021894-lq8yr710 50 9 8 8 CD cord-021894-lq8yr710 50 10 , , , cord-021894-lq8yr710 50 11 10 10 CD cord-021894-lq8yr710 50 12 rising rise VBG cord-021894-lq8yr710 50 13 to to IN cord-021894-lq8yr710 50 14 204 204 CD cord-021894-lq8yr710 50 15 per per IN cord-021894-lq8yr710 50 16 1000 1000 CD cord-021894-lq8yr710 50 17 when when WRB cord-021894-lq8yr710 50 18 a a DT cord-021894-lq8yr710 50 19 broader broad JJR cord-021894-lq8yr710 50 20 definition definition NN cord-021894-lq8yr710 50 21 of of IN cord-021894-lq8yr710 50 22 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 50 23 was be VBD cord-021894-lq8yr710 50 24 used use VBN cord-021894-lq8yr710 50 25 to to TO cord-021894-lq8yr710 50 26 capture capture VB cord-021894-lq8yr710 50 27 potential potential JJ cord-021894-lq8yr710 50 28 cases case NNS cord-021894-lq8yr710 50 29 . . . cord-021894-lq8yr710 51 1 8 8 CD cord-021894-lq8yr710 52 1 This this DT cord-021894-lq8yr710 52 2 study study NN cord-021894-lq8yr710 52 3 highlights highlight VBZ cord-021894-lq8yr710 52 4 that that IN cord-021894-lq8yr710 52 5 in in IN cord-021894-lq8yr710 52 6 children child NNS cord-021894-lq8yr710 52 7 with with IN cord-021894-lq8yr710 52 8 typical typical JJ cord-021894-lq8yr710 52 9 lower low JJR cord-021894-lq8yr710 52 10 respiratory respiratory JJ cord-021894-lq8yr710 52 11 tract tract NN cord-021894-lq8yr710 52 12 signs sign NNS cord-021894-lq8yr710 52 13 and and CC cord-021894-lq8yr710 52 14 symptoms symptom NNS cord-021894-lq8yr710 52 15 , , , cord-021894-lq8yr710 52 16 clinicians clinician NNS cord-021894-lq8yr710 52 17 may may MD cord-021894-lq8yr710 52 18 not not RB cord-021894-lq8yr710 52 19 ascribe ascribe VB cord-021894-lq8yr710 52 20 the the DT cord-021894-lq8yr710 52 21 discrete discrete JJ cord-021894-lq8yr710 52 22 diagnosis diagnosis NN cord-021894-lq8yr710 52 23 of of IN cord-021894-lq8yr710 52 24 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 52 25 ; ; : cord-021894-lq8yr710 52 26 a a DT cord-021894-lq8yr710 52 27 finding finding NN cord-021894-lq8yr710 52 28 also also RB cord-021894-lq8yr710 52 29 found find VBD cord-021894-lq8yr710 52 30 KEYWORDS KEYWORDS NNP cord-021894-lq8yr710 52 31 bronchiolitis bronchiolitis VB cord-021894-lq8yr710 52 32 viral viral JJ cord-021894-lq8yr710 52 33 lower low JJR cord-021894-lq8yr710 52 34 respiratory respiratory JJ cord-021894-lq8yr710 52 35 tract tract NN cord-021894-lq8yr710 52 36 infection infection NN cord-021894-lq8yr710 52 37 wheeze wheeze VBP cord-021894-lq8yr710 52 38 respiratory respiratory JJ cord-021894-lq8yr710 52 39 syncytial syncytial JJ cord-021894-lq8yr710 52 40 virus virus NN cord-021894-lq8yr710 52 41 ABSTRACT ABSTRACT NNP cord-021894-lq8yr710 52 42 Acute acute JJ cord-021894-lq8yr710 52 43 viral viral JJ cord-021894-lq8yr710 52 44 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 52 45 is be VBZ cord-021894-lq8yr710 52 46 a a DT cord-021894-lq8yr710 52 47 common common JJ cord-021894-lq8yr710 52 48 viral viral JJ cord-021894-lq8yr710 52 49 lower low JJR cord-021894-lq8yr710 52 50 respiratory respiratory JJ cord-021894-lq8yr710 52 51 tract tract NN cord-021894-lq8yr710 52 52 infection infection NN cord-021894-lq8yr710 52 53 in in IN cord-021894-lq8yr710 52 54 young young JJ cord-021894-lq8yr710 52 55 children child NNS cord-021894-lq8yr710 52 56 . . . cord-021894-lq8yr710 53 1 Most most RBS cord-021894-lq8yr710 53 2 typically typically RB cord-021894-lq8yr710 53 3 caused cause VBN cord-021894-lq8yr710 53 4 by by IN cord-021894-lq8yr710 53 5 respiratory respiratory JJ cord-021894-lq8yr710 53 6 syncytial syncytial JJ cord-021894-lq8yr710 53 7 virus virus NN cord-021894-lq8yr710 53 8 in in IN cord-021894-lq8yr710 53 9 70 70 CD cord-021894-lq8yr710 53 10 % % NN cord-021894-lq8yr710 53 11 of of IN cord-021894-lq8yr710 53 12 cases case NNS cord-021894-lq8yr710 53 13 , , , cord-021894-lq8yr710 53 14 the the DT cord-021894-lq8yr710 53 15 condition condition NN cord-021894-lq8yr710 53 16 lasts last VBZ cord-021894-lq8yr710 53 17 for for IN cord-021894-lq8yr710 53 18 4 4 CD cord-021894-lq8yr710 53 19 to to TO cord-021894-lq8yr710 53 20 7 7 CD cord-021894-lq8yr710 53 21 days day NNS cord-021894-lq8yr710 53 22 , , , cord-021894-lq8yr710 53 23 with with IN cord-021894-lq8yr710 53 24 a a DT cord-021894-lq8yr710 53 25 prolonged prolonged JJ cord-021894-lq8yr710 53 26 cough cough NN cord-021894-lq8yr710 53 27 in in IN cord-021894-lq8yr710 53 28 many many JJ cord-021894-lq8yr710 53 29 . . . cord-021894-lq8yr710 54 1 Children child NNS cord-021894-lq8yr710 54 2 with with IN cord-021894-lq8yr710 54 3 comorbidity comorbidity NN cord-021894-lq8yr710 54 4 , , , cord-021894-lq8yr710 54 5 particularly particularly RB cord-021894-lq8yr710 54 6 those those DT cord-021894-lq8yr710 54 7 born bear VBN cord-021894-lq8yr710 54 8 prematurely prematurely RB cord-021894-lq8yr710 54 9 or or CC cord-021894-lq8yr710 54 10 with with IN cord-021894-lq8yr710 54 11 significant significant JJ cord-021894-lq8yr710 54 12 congenital congenital JJ cord-021894-lq8yr710 54 13 heart heart NN cord-021894-lq8yr710 54 14 disease disease NN cord-021894-lq8yr710 54 15 , , , cord-021894-lq8yr710 54 16 are be VBP cord-021894-lq8yr710 54 17 at at IN cord-021894-lq8yr710 54 18 risk risk NN cord-021894-lq8yr710 54 19 of of IN cord-021894-lq8yr710 54 20 more more RBR cord-021894-lq8yr710 54 21 severe severe JJ cord-021894-lq8yr710 54 22 disease disease NN cord-021894-lq8yr710 54 23 . . . cord-021894-lq8yr710 55 1 Nasal nasal JJ cord-021894-lq8yr710 55 2 obstruction obstruction NN cord-021894-lq8yr710 55 3 progresses progress VBZ cord-021894-lq8yr710 55 4 over over IN cord-021894-lq8yr710 55 5 3 3 CD cord-021894-lq8yr710 55 6 to to TO cord-021894-lq8yr710 55 7 4 4 CD cord-021894-lq8yr710 55 8 days day NNS cord-021894-lq8yr710 55 9 to to IN cord-021894-lq8yr710 55 10 difficulty difficulty VB cord-021894-lq8yr710 55 11 with with IN cord-021894-lq8yr710 55 12 feeding feeding NN cord-021894-lq8yr710 55 13 and and CC cord-021894-lq8yr710 55 14 increased increase VBN cord-021894-lq8yr710 55 15 work work NN cord-021894-lq8yr710 55 16 of of IN cord-021894-lq8yr710 55 17 breathing breathe VBG cord-021894-lq8yr710 55 18 with with IN cord-021894-lq8yr710 55 19 hypoxemia hypoxemia NN cord-021894-lq8yr710 55 20 . . . cord-021894-lq8yr710 56 1 Crackles crackle NNS cord-021894-lq8yr710 56 2 and/or and/or CC cord-021894-lq8yr710 56 3 wheeze wheeze NN cord-021894-lq8yr710 56 4 may may MD cord-021894-lq8yr710 56 5 be be VB cord-021894-lq8yr710 56 6 auscultated auscultate VBN cord-021894-lq8yr710 56 7 . . . cord-021894-lq8yr710 57 1 Apnoea Apnoea NNP cord-021894-lq8yr710 57 2 may may MD cord-021894-lq8yr710 57 3 be be VB cord-021894-lq8yr710 57 4 a a DT cord-021894-lq8yr710 57 5 presenting present VBG cord-021894-lq8yr710 57 6 sign sign NN cord-021894-lq8yr710 57 7 in in IN cord-021894-lq8yr710 57 8 those those DT cord-021894-lq8yr710 57 9 less less JJR cord-021894-lq8yr710 57 10 than than IN cord-021894-lq8yr710 57 11 3 3 CD cord-021894-lq8yr710 57 12 months month NNS cord-021894-lq8yr710 57 13 of of IN cord-021894-lq8yr710 57 14 age age NN cord-021894-lq8yr710 57 15 . . . cord-021894-lq8yr710 58 1 Viral viral JJ cord-021894-lq8yr710 58 2 load load NN cord-021894-lq8yr710 58 3 is be VBZ cord-021894-lq8yr710 58 4 highest high JJS cord-021894-lq8yr710 58 5 at at IN cord-021894-lq8yr710 58 6 peak peak NN cord-021894-lq8yr710 58 7 of of IN cord-021894-lq8yr710 58 8 symptoms symptom NNS cord-021894-lq8yr710 58 9 and and CC cord-021894-lq8yr710 58 10 in in IN cord-021894-lq8yr710 58 11 those those DT cord-021894-lq8yr710 58 12 with with IN cord-021894-lq8yr710 58 13 more more RBR cord-021894-lq8yr710 58 14 severe severe JJ cord-021894-lq8yr710 58 15 disease disease NN cord-021894-lq8yr710 58 16 . . . cord-021894-lq8yr710 59 1 Approximately approximately RB cord-021894-lq8yr710 59 2 2 2 CD cord-021894-lq8yr710 59 3 % % NN cord-021894-lq8yr710 59 4 to to TO cord-021894-lq8yr710 59 5 3 3 CD cord-021894-lq8yr710 59 6 % % NN cord-021894-lq8yr710 59 7 of of IN cord-021894-lq8yr710 59 8 all all DT cord-021894-lq8yr710 59 9 children child NNS cord-021894-lq8yr710 59 10 are be VBP cord-021894-lq8yr710 59 11 admitted admit VBN cord-021894-lq8yr710 59 12 to to IN cord-021894-lq8yr710 59 13 hospital hospital NN cord-021894-lq8yr710 59 14 with with IN cord-021894-lq8yr710 59 15 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 59 16 . . . cord-021894-lq8yr710 60 1 The the DT cord-021894-lq8yr710 60 2 differential differential JJ cord-021894-lq8yr710 60 3 diagnosis diagnosis NN cord-021894-lq8yr710 60 4 may may MD cord-021894-lq8yr710 60 5 include include VB cord-021894-lq8yr710 60 6 bacterial bacterial JJ cord-021894-lq8yr710 60 7 pneumonia pneumonia NN cord-021894-lq8yr710 60 8 , , , cord-021894-lq8yr710 60 9 congenital congenital JJ cord-021894-lq8yr710 60 10 lesions lesion NNS cord-021894-lq8yr710 60 11 of of IN cord-021894-lq8yr710 60 12 the the DT cord-021894-lq8yr710 60 13 lung lung NN cord-021894-lq8yr710 60 14 or or CC cord-021894-lq8yr710 60 15 heart heart NN cord-021894-lq8yr710 60 16 , , , cord-021894-lq8yr710 60 17 or or CC cord-021894-lq8yr710 60 18 an an DT cord-021894-lq8yr710 60 19 interstitial interstitial JJ cord-021894-lq8yr710 60 20 lung lung NN cord-021894-lq8yr710 60 21 disease disease NN cord-021894-lq8yr710 60 22 . . . cord-021894-lq8yr710 61 1 There there EX cord-021894-lq8yr710 61 2 are be VBP cord-021894-lq8yr710 61 3 no no DT cord-021894-lq8yr710 61 4 effective effective JJ cord-021894-lq8yr710 61 5 treatments treatment NNS cord-021894-lq8yr710 61 6 , , , cord-021894-lq8yr710 61 7 and and CC cord-021894-lq8yr710 61 8 admission admission NN cord-021894-lq8yr710 61 9 is be VBZ cord-021894-lq8yr710 61 10 for for IN cord-021894-lq8yr710 61 11 feeding feed VBG cord-021894-lq8yr710 61 12 support support NN cord-021894-lq8yr710 61 13 ( ( -LRB- cord-021894-lq8yr710 61 14 by by IN cord-021894-lq8yr710 61 15 nasogastric nasogastric NN cord-021894-lq8yr710 61 16 or or CC cord-021894-lq8yr710 61 17 intravenous intravenous JJ cord-021894-lq8yr710 61 18 fluids fluid NNS cord-021894-lq8yr710 61 19 ) ) -RRB- cord-021894-lq8yr710 61 20 or or CC cord-021894-lq8yr710 61 21 treatment treatment NN cord-021894-lq8yr710 61 22 of of IN cord-021894-lq8yr710 61 23 hypoxemia hypoxemia NN cord-021894-lq8yr710 61 24 . . . cord-021894-lq8yr710 62 1 Critical critical JJ cord-021894-lq8yr710 62 2 care care NN cord-021894-lq8yr710 62 3 support support NN cord-021894-lq8yr710 62 4 is be VBZ cord-021894-lq8yr710 62 5 required require VBN cord-021894-lq8yr710 62 6 for for IN cord-021894-lq8yr710 62 7 some some DT cord-021894-lq8yr710 62 8 infants infant NNS cord-021894-lq8yr710 62 9 experiencing experience VBG cord-021894-lq8yr710 62 10 respiratory respiratory JJ cord-021894-lq8yr710 62 11 failure failure NN cord-021894-lq8yr710 62 12 , , , cord-021894-lq8yr710 62 13 though though IN cord-021894-lq8yr710 62 14 mortality mortality NN cord-021894-lq8yr710 62 15 rates rate NNS cord-021894-lq8yr710 62 16 remain remain VBP cord-021894-lq8yr710 62 17 unchanged unchanged JJ cord-021894-lq8yr710 62 18 . . . cord-021894-lq8yr710 63 1 Practice practice VB cord-021894-lq8yr710 63 2 within within IN cord-021894-lq8yr710 63 3 and and CC cord-021894-lq8yr710 63 4 between between IN cord-021894-lq8yr710 63 5 countries country NNS cord-021894-lq8yr710 63 6 varies vary VBZ cord-021894-lq8yr710 63 7 significantly significantly RB cord-021894-lq8yr710 63 8 and and CC cord-021894-lq8yr710 63 9 alignment alignment NN cord-021894-lq8yr710 63 10 of of IN cord-021894-lq8yr710 63 11 practice practice NN cord-021894-lq8yr710 63 12 is be VBZ cord-021894-lq8yr710 63 13 a a DT cord-021894-lq8yr710 63 14 common common JJ cord-021894-lq8yr710 63 15 goal goal NN cord-021894-lq8yr710 63 16 of of IN cord-021894-lq8yr710 63 17 guidelines guideline NNS cord-021894-lq8yr710 63 18 . . . cord-021894-lq8yr710 64 1 Vaccines vaccine NNS cord-021894-lq8yr710 64 2 for for IN cord-021894-lq8yr710 64 3 RSV RSV NNP cord-021894-lq8yr710 64 4 are be VBP cord-021894-lq8yr710 64 5 in in IN cord-021894-lq8yr710 64 6 advanced advanced JJ cord-021894-lq8yr710 64 7 development development NN cord-021894-lq8yr710 64 8 , , , cord-021894-lq8yr710 64 9 as as IN cord-021894-lq8yr710 64 10 are be VBP cord-021894-lq8yr710 64 11 several several JJ cord-021894-lq8yr710 64 12 antiviral antiviral JJ cord-021894-lq8yr710 64 13 therapies therapy NNS cord-021894-lq8yr710 64 14 for for IN cord-021894-lq8yr710 64 15 RSV RSV NNP cord-021894-lq8yr710 64 16 . . . cord-021894-lq8yr710 65 1 In in IN cord-021894-lq8yr710 65 2 most most JJS cord-021894-lq8yr710 65 3 children child NNS cord-021894-lq8yr710 65 4 , , , cord-021894-lq8yr710 65 5 acute acute JJ cord-021894-lq8yr710 65 6 symptoms symptom NNS cord-021894-lq8yr710 65 7 improve improve VBP cord-021894-lq8yr710 65 8 within within IN cord-021894-lq8yr710 65 9 5 5 CD cord-021894-lq8yr710 65 10 to to TO cord-021894-lq8yr710 65 11 7 7 CD cord-021894-lq8yr710 65 12 days day NNS cord-021894-lq8yr710 65 13 and and CC cord-021894-lq8yr710 65 14 cough cough NN cord-021894-lq8yr710 65 15 by by IN cord-021894-lq8yr710 65 16 2 2 CD cord-021894-lq8yr710 65 17 weeks week NNS cord-021894-lq8yr710 65 18 . . . cord-021894-lq8yr710 66 1 Recurrent recurrent JJ cord-021894-lq8yr710 66 2 wheeze wheeze NN cord-021894-lq8yr710 66 3 is be VBZ cord-021894-lq8yr710 66 4 common common JJ cord-021894-lq8yr710 66 5 following follow VBG cord-021894-lq8yr710 66 6 acute acute JJ cord-021894-lq8yr710 66 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 66 8 and and CC cord-021894-lq8yr710 66 9 a a DT cord-021894-lq8yr710 66 10 good good JJ cord-021894-lq8yr710 66 11 association association NN cord-021894-lq8yr710 66 12 with with IN cord-021894-lq8yr710 66 13 a a DT cord-021894-lq8yr710 66 14 diagnosis diagnosis NN cord-021894-lq8yr710 66 15 of of IN cord-021894-lq8yr710 66 16 asthma asthma NN cord-021894-lq8yr710 66 17 in in IN cord-021894-lq8yr710 66 18 childhood childhood NN cord-021894-lq8yr710 66 19 . . . cord-021894-lq8yr710 67 1 For for IN cord-021894-lq8yr710 67 2 infants infant NNS cord-021894-lq8yr710 67 3 born bear VBN cord-021894-lq8yr710 67 4 ≤ ≤ NNP cord-021894-lq8yr710 67 5 32 32 CD cord-021894-lq8yr710 67 6 weeks week NNS cord-021894-lq8yr710 67 7 gestation gestation NN cord-021894-lq8yr710 67 8 , , , cord-021894-lq8yr710 67 9 75 75 CD cord-021894-lq8yr710 67 10 % % NN cord-021894-lq8yr710 67 11 of of IN cord-021894-lq8yr710 67 12 infants infant NNS cord-021894-lq8yr710 67 13 will will MD cord-021894-lq8yr710 67 14 have have VB cord-021894-lq8yr710 67 15 a a DT cord-021894-lq8yr710 67 16 lower low JJR cord-021894-lq8yr710 67 17 respiratory respiratory JJ cord-021894-lq8yr710 67 18 tract tract NN cord-021894-lq8yr710 67 19 infection infection NN cord-021894-lq8yr710 67 20 in in IN cord-021894-lq8yr710 67 21 the the DT cord-021894-lq8yr710 67 22 first first JJ cord-021894-lq8yr710 67 23 year year NN cord-021894-lq8yr710 67 24 of of IN cord-021894-lq8yr710 67 25 life life NN cord-021894-lq8yr710 67 26 , , , cord-021894-lq8yr710 67 27 with with IN cord-021894-lq8yr710 67 28 35 35 CD cord-021894-lq8yr710 67 29 % % NN cord-021894-lq8yr710 67 30 RSV RSV NNP cord-021894-lq8yr710 67 31 positive positive JJ cord-021894-lq8yr710 67 32 and and CC cord-021894-lq8yr710 67 33 40 40 CD cord-021894-lq8yr710 67 34 % % NN cord-021894-lq8yr710 68 1 RSV RSV NNP cord-021894-lq8yr710 68 2 negative negative JJ cord-021894-lq8yr710 68 3 ; ; : cord-021894-lq8yr710 68 4 of of IN cord-021894-lq8yr710 68 5 these these DT cord-021894-lq8yr710 68 6 infants infant NNS cord-021894-lq8yr710 68 7 , , , cord-021894-lq8yr710 68 8 41 41 CD cord-021894-lq8yr710 68 9 % % NN cord-021894-lq8yr710 68 10 of of IN cord-021894-lq8yr710 68 11 RSV RSV NNP cord-021894-lq8yr710 68 12 positive positive JJ cord-021894-lq8yr710 68 13 will will MD cord-021894-lq8yr710 68 14 be be VB cord-021894-lq8yr710 68 15 admitted admit VBN cord-021894-lq8yr710 68 16 to to IN cord-021894-lq8yr710 68 17 the the DT cord-021894-lq8yr710 68 18 hospital hospital NN cord-021894-lq8yr710 68 19 versus versus IN cord-021894-lq8yr710 68 20 18 18 CD cord-021894-lq8yr710 68 21 % % NN cord-021894-lq8yr710 68 22 of of IN cord-021894-lq8yr710 68 23 RSV RSV NNP cord-021894-lq8yr710 68 24 negative negative JJ cord-021894-lq8yr710 68 25 . . . cord-021894-lq8yr710 69 1 27 27 CD cord-021894-lq8yr710 70 1 Recent recent JJ cord-021894-lq8yr710 70 2 studies study NNS cord-021894-lq8yr710 70 3 suggest suggest VBP cord-021894-lq8yr710 70 4 that that IN cord-021894-lq8yr710 70 5 hospitalization hospitalization NN cord-021894-lq8yr710 70 6 rates rate NNS cord-021894-lq8yr710 70 7 for for IN cord-021894-lq8yr710 70 8 high high JJ cord-021894-lq8yr710 70 9 - - HYPH cord-021894-lq8yr710 70 10 risk risk NN cord-021894-lq8yr710 70 11 infants infant NNS cord-021894-lq8yr710 70 12 due due JJ cord-021894-lq8yr710 70 13 to to IN cord-021894-lq8yr710 70 14 RSV RSV NNP cord-021894-lq8yr710 70 15 are be VBP cord-021894-lq8yr710 70 16 reducing reduce VBG cord-021894-lq8yr710 70 17 over over IN cord-021894-lq8yr710 70 18 time time NN cord-021894-lq8yr710 70 19 and and CC cord-021894-lq8yr710 70 20 are be VBP cord-021894-lq8yr710 70 21 now now RB cord-021894-lq8yr710 70 22 similar similar JJ cord-021894-lq8yr710 70 23 to to IN cord-021894-lq8yr710 70 24 those those DT cord-021894-lq8yr710 70 25 for for IN cord-021894-lq8yr710 70 26 RSV RSV NNP cord-021894-lq8yr710 70 27 negative negative JJ cord-021894-lq8yr710 70 28 , , , cord-021894-lq8yr710 70 29 possibly possibly RB cord-021894-lq8yr710 70 30 as as IN cord-021894-lq8yr710 70 31 a a DT cord-021894-lq8yr710 70 32 result result NN cord-021894-lq8yr710 70 33 of of IN cord-021894-lq8yr710 70 34 improvements improvement NNS cord-021894-lq8yr710 70 35 in in IN cord-021894-lq8yr710 70 36 neonatal neonatal JJ cord-021894-lq8yr710 70 37 care care NN cord-021894-lq8yr710 70 38 or or CC cord-021894-lq8yr710 70 39 immunoprophylaxis immunoprophylaxis NN cord-021894-lq8yr710 70 40 in in IN cord-021894-lq8yr710 70 41 high high JJ cord-021894-lq8yr710 70 42 - - HYPH cord-021894-lq8yr710 70 43 risk risk NN cord-021894-lq8yr710 70 44 groups group NNS cord-021894-lq8yr710 71 1 ( ( -LRB- cord-021894-lq8yr710 71 2 Fig Fig NNP cord-021894-lq8yr710 71 3 . . . cord-021894-lq8yr710 71 4 24 24 CD cord-021894-lq8yr710 71 5 .1 .1 CD cord-021894-lq8yr710 71 6 ) ) -RRB- cord-021894-lq8yr710 71 7 . . . cord-021894-lq8yr710 72 1 28 28 CD cord-021894-lq8yr710 72 2 , , , cord-021894-lq8yr710 72 3 29 29 CD cord-021894-lq8yr710 72 4 Risk risk NN cord-021894-lq8yr710 72 5 of of IN cord-021894-lq8yr710 72 6 death death NN cord-021894-lq8yr710 72 7 is be VBZ cord-021894-lq8yr710 72 8 much much RB cord-021894-lq8yr710 72 9 higher high JJR cord-021894-lq8yr710 72 10 amongst amongst IN cord-021894-lq8yr710 72 11 high high JJ cord-021894-lq8yr710 72 12 - - HYPH cord-021894-lq8yr710 72 13 risk risk NN cord-021894-lq8yr710 72 14 groups group NNS cord-021894-lq8yr710 72 15 who who WP cord-021894-lq8yr710 72 16 are be VBP cord-021894-lq8yr710 72 17 RSV RSV NNP cord-021894-lq8yr710 72 18 positive positive JJ cord-021894-lq8yr710 72 19 , , , cord-021894-lq8yr710 72 20 including include VBG cord-021894-lq8yr710 72 21 preterm preterm NNS cord-021894-lq8yr710 72 22 ( ( -LRB- cord-021894-lq8yr710 72 23 1.2 1.2 CD cord-021894-lq8yr710 72 24 % % NN cord-021894-lq8yr710 72 25 ) ) -RRB- cord-021894-lq8yr710 72 26 , , , cord-021894-lq8yr710 72 27 congenital congenital JJ cord-021894-lq8yr710 72 28 heart heart NN cord-021894-lq8yr710 72 29 disease disease NN cord-021894-lq8yr710 72 30 ( ( -LRB- cord-021894-lq8yr710 72 31 5.2 5.2 CD cord-021894-lq8yr710 72 32 % % NN cord-021894-lq8yr710 72 33 ) ) -RRB- cord-021894-lq8yr710 72 34 , , , cord-021894-lq8yr710 72 35 and and CC cord-021894-lq8yr710 72 36 bronchopulmonary bronchopulmonary JJ cord-021894-lq8yr710 72 37 dysplasia dysplasia NN cord-021894-lq8yr710 72 38 ( ( -LRB- cord-021894-lq8yr710 72 39 7.0 7.0 CD cord-021894-lq8yr710 72 40 % % NN cord-021894-lq8yr710 72 41 ) ) -RRB- cord-021894-lq8yr710 72 42 . . . cord-021894-lq8yr710 73 1 17 17 CD cord-021894-lq8yr710 73 2 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 73 3 has have VBZ cord-021894-lq8yr710 73 4 a a DT cord-021894-lq8yr710 73 5 viral viral JJ cord-021894-lq8yr710 73 6 etiology etiology NN cord-021894-lq8yr710 73 7 , , , cord-021894-lq8yr710 73 8 with with IN cord-021894-lq8yr710 73 9 RSV RSV NNP cord-021894-lq8yr710 73 10 the the DT cord-021894-lq8yr710 73 11 most most RBS cord-021894-lq8yr710 73 12 common common JJ cord-021894-lq8yr710 73 13 cause cause NN cord-021894-lq8yr710 73 14 , , , cord-021894-lq8yr710 73 15 reported report VBN cord-021894-lq8yr710 73 16 in in IN cord-021894-lq8yr710 73 17 43 43 CD cord-021894-lq8yr710 73 18 % % NN cord-021894-lq8yr710 73 19 to to TO cord-021894-lq8yr710 73 20 75 75 CD cord-021894-lq8yr710 73 21 % % NN cord-021894-lq8yr710 73 22 30,31 30,31 CD cord-021894-lq8yr710 73 23 of of IN cord-021894-lq8yr710 73 24 cases case NNS cord-021894-lq8yr710 73 25 . . . cord-021894-lq8yr710 74 1 Other other JJ cord-021894-lq8yr710 74 2 viruses virus NNS cord-021894-lq8yr710 74 3 associated associate VBN cord-021894-lq8yr710 74 4 with with IN cord-021894-lq8yr710 74 5 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 74 6 are be VBP cord-021894-lq8yr710 74 7 human human JJ cord-021894-lq8yr710 74 8 rhinovirus rhinovirus NN cord-021894-lq8yr710 74 9 ( ( -LRB- cord-021894-lq8yr710 74 10 18 18 CD cord-021894-lq8yr710 74 11 % % NN cord-021894-lq8yr710 74 12 ) ) -RRB- cord-021894-lq8yr710 74 13 , , , cord-021894-lq8yr710 74 14 influenza influenza NN cord-021894-lq8yr710 74 15 , , , cord-021894-lq8yr710 74 16 coronavirus coronavirus NN cord-021894-lq8yr710 74 17 , , , cord-021894-lq8yr710 74 18 human human JJ cord-021894-lq8yr710 74 19 metapneumovirus metapneumovirus NN cord-021894-lq8yr710 74 20 , , , cord-021894-lq8yr710 74 21 adenovirus adenovirus NN cord-021894-lq8yr710 74 22 , , , cord-021894-lq8yr710 74 23 parainfluenza parainfluenza NNP cord-021894-lq8yr710 74 24 virus virus NNP cord-021894-lq8yr710 74 25 and and CC cord-021894-lq8yr710 74 26 human human JJ cord-021894-lq8yr710 74 27 Boca Boca NNP cord-021894-lq8yr710 74 28 virus virus NN cord-021894-lq8yr710 74 29 30 30 CD cord-021894-lq8yr710 74 30 , , , cord-021894-lq8yr710 74 31 31 31 CD cord-021894-lq8yr710 74 32 ; ; : cord-021894-lq8yr710 74 33 that that RB cord-021894-lq8yr710 74 34 is is RB cord-021894-lq8yr710 74 35 , , , cord-021894-lq8yr710 74 36 " " `` cord-021894-lq8yr710 74 37 any any DT cord-021894-lq8yr710 74 38 respiratory respiratory JJ cord-021894-lq8yr710 74 39 virus virus NN cord-021894-lq8yr710 74 40 . . . cord-021894-lq8yr710 75 1 " " '' cord-021894-lq8yr710 76 1 RSV RSV NNP cord-021894-lq8yr710 76 2 has have VBZ cord-021894-lq8yr710 76 3 two two CD cord-021894-lq8yr710 76 4 strains strain NNS cord-021894-lq8yr710 76 5 , , , cord-021894-lq8yr710 76 6 A a NN cord-021894-lq8yr710 76 7 and and CC cord-021894-lq8yr710 76 8 B b NN cord-021894-lq8yr710 76 9 , , , cord-021894-lq8yr710 76 10 with with IN cord-021894-lq8yr710 77 1 RSV RSV NNP cord-021894-lq8yr710 77 2 A A NNP cord-021894-lq8yr710 77 3 associated associate VBN cord-021894-lq8yr710 77 4 with with IN cord-021894-lq8yr710 77 5 more more RBR cord-021894-lq8yr710 77 6 severe severe JJ cord-021894-lq8yr710 77 7 disease disease NN cord-021894-lq8yr710 77 8 . . . cord-021894-lq8yr710 78 1 32 32 CD cord-021894-lq8yr710 78 2 , , , cord-021894-lq8yr710 78 3 33 33 CD cord-021894-lq8yr710 78 4 Reinfection Reinfection NNP cord-021894-lq8yr710 78 5 in in IN cord-021894-lq8yr710 78 6 the the DT cord-021894-lq8yr710 78 7 same same JJ cord-021894-lq8yr710 78 8 season season NN cord-021894-lq8yr710 78 9 with with IN cord-021894-lq8yr710 78 10 the the DT cord-021894-lq8yr710 78 11 same same JJ cord-021894-lq8yr710 78 12 or or CC cord-021894-lq8yr710 78 13 different different JJ cord-021894-lq8yr710 78 14 strain strain NN cord-021894-lq8yr710 78 15 is be VBZ cord-021894-lq8yr710 78 16 possible possible JJ cord-021894-lq8yr710 78 17 . . . cord-021894-lq8yr710 79 1 34 34 CD cord-021894-lq8yr710 80 1 As as IN cord-021894-lq8yr710 80 2 a a DT cord-021894-lq8yr710 80 3 sole sole JJ cord-021894-lq8yr710 80 4 infecting infect VBG cord-021894-lq8yr710 80 5 agent agent NN cord-021894-lq8yr710 80 6 , , , cord-021894-lq8yr710 80 7 RSV RSV NNP cord-021894-lq8yr710 80 8 is be VBZ cord-021894-lq8yr710 80 9 associated associate VBN cord-021894-lq8yr710 80 10 with with IN cord-021894-lq8yr710 80 11 more more RBR cord-021894-lq8yr710 80 12 severe severe JJ cord-021894-lq8yr710 80 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 80 14 than than IN cord-021894-lq8yr710 80 15 other other JJ cord-021894-lq8yr710 80 16 single single JJ cord-021894-lq8yr710 80 17 respiratory respiratory JJ cord-021894-lq8yr710 80 18 virus virus NN cord-021894-lq8yr710 80 19 infections infection NNS cord-021894-lq8yr710 80 20 . . . cord-021894-lq8yr710 81 1 5 5 CD cord-021894-lq8yr710 81 2 Coinfection Coinfection NNP cord-021894-lq8yr710 81 3 of of IN cord-021894-lq8yr710 81 4 RSV RSV NNP cord-021894-lq8yr710 81 5 with with IN cord-021894-lq8yr710 81 6 rhinovirus rhinovirus NN cord-021894-lq8yr710 81 7 can can MD cord-021894-lq8yr710 81 8 produce produce VB cord-021894-lq8yr710 81 9 even even RB cord-021894-lq8yr710 81 10 more more RBR cord-021894-lq8yr710 81 11 severe severe JJ cord-021894-lq8yr710 81 12 disease disease NN cord-021894-lq8yr710 81 13 . . . cord-021894-lq8yr710 82 1 35 35 CD cord-021894-lq8yr710 82 2 RSV RSV NNP cord-021894-lq8yr710 82 3 is be VBZ cord-021894-lq8yr710 82 4 the the DT cord-021894-lq8yr710 82 5 most most RBS cord-021894-lq8yr710 82 6 common common JJ cord-021894-lq8yr710 82 7 infectious infectious JJ cord-021894-lq8yr710 82 8 agent agent NN cord-021894-lq8yr710 82 9 in in IN cord-021894-lq8yr710 82 10 children child NNS cord-021894-lq8yr710 82 11 admitted admit VBN cord-021894-lq8yr710 82 12 to to IN cord-021894-lq8yr710 82 13 the the DT cord-021894-lq8yr710 82 14 hospital hospital NN cord-021894-lq8yr710 82 15 with with IN cord-021894-lq8yr710 82 16 radiological radiological JJ cord-021894-lq8yr710 82 17 features feature NNS cord-021894-lq8yr710 82 18 consistent consistent JJ cord-021894-lq8yr710 82 19 with with IN cord-021894-lq8yr710 82 20 pneumonia pneumonia NN cord-021894-lq8yr710 82 21 ( ( -LRB- cord-021894-lq8yr710 82 22 occurring occur VBG cord-021894-lq8yr710 82 23 in in IN cord-021894-lq8yr710 82 24 28 28 CD cord-021894-lq8yr710 82 25 % % NN cord-021894-lq8yr710 82 26 of of IN cord-021894-lq8yr710 82 27 children child NNS cord-021894-lq8yr710 82 28 - - : cord-021894-lq8yr710 82 29 most most RBS cord-021894-lq8yr710 82 30 commonly commonly RB cord-021894-lq8yr710 82 31 those those DT cord-021894-lq8yr710 82 32 under under IN cord-021894-lq8yr710 82 33 5 5 CD cord-021894-lq8yr710 82 34 years year NNS cord-021894-lq8yr710 82 35 of of IN cord-021894-lq8yr710 82 36 age age NN cord-021894-lq8yr710 82 37 ) ) -RRB- cord-021894-lq8yr710 82 38 . . . cord-021894-lq8yr710 83 1 36 36 CD cord-021894-lq8yr710 84 1 In in IN cord-021894-lq8yr710 84 2 young young JJ cord-021894-lq8yr710 84 3 children child NNS cord-021894-lq8yr710 84 4 who who WP cord-021894-lq8yr710 84 5 are be VBP cord-021894-lq8yr710 84 6 well well RB cord-021894-lq8yr710 84 7 immunized immunize VBN cord-021894-lq8yr710 84 8 , , , cord-021894-lq8yr710 84 9 RSV RSV NNP cord-021894-lq8yr710 84 10 represents represent VBZ cord-021894-lq8yr710 84 11 the the DT cord-021894-lq8yr710 84 12 most most RBS cord-021894-lq8yr710 84 13 common common JJ cord-021894-lq8yr710 84 14 cause cause NN cord-021894-lq8yr710 84 15 of of IN cord-021894-lq8yr710 84 16 lower low JJR cord-021894-lq8yr710 84 17 respiratory respiratory JJ cord-021894-lq8yr710 84 18 tract tract NN cord-021894-lq8yr710 84 19 infection infection NN cord-021894-lq8yr710 84 20 . . . cord-021894-lq8yr710 85 1 37 37 CD cord-021894-lq8yr710 85 2 _SP cord-021894-lq8yr710 86 1 What what WP cord-021894-lq8yr710 86 2 commences commence VBZ cord-021894-lq8yr710 86 3 as as IN cord-021894-lq8yr710 86 4 an an DT cord-021894-lq8yr710 86 5 upper upper JJ cord-021894-lq8yr710 86 6 respiratory respiratory JJ cord-021894-lq8yr710 86 7 tract tract NN cord-021894-lq8yr710 86 8 infection infection NN cord-021894-lq8yr710 86 9 becomes become VBZ cord-021894-lq8yr710 86 10 a a DT cord-021894-lq8yr710 86 11 lower low JJR cord-021894-lq8yr710 86 12 respiratory respiratory JJ cord-021894-lq8yr710 86 13 tract tract NN cord-021894-lq8yr710 86 14 infection infection NN cord-021894-lq8yr710 86 15 over over IN cord-021894-lq8yr710 86 16 the the DT cord-021894-lq8yr710 86 17 course course NN cord-021894-lq8yr710 86 18 of of IN cord-021894-lq8yr710 86 19 2 2 CD cord-021894-lq8yr710 86 20 to to TO cord-021894-lq8yr710 86 21 5 5 CD cord-021894-lq8yr710 86 22 days day NNS cord-021894-lq8yr710 86 23 . . . cord-021894-lq8yr710 87 1 Infants infant NNS cord-021894-lq8yr710 87 2 are be VBP cord-021894-lq8yr710 87 3 particularly particularly RB cord-021894-lq8yr710 87 4 susceptible susceptible JJ cord-021894-lq8yr710 87 5 as as IN cord-021894-lq8yr710 87 6 they -PRON- PRP cord-021894-lq8yr710 87 7 have have VBP cord-021894-lq8yr710 87 8 small small JJ cord-021894-lq8yr710 87 9 bronchi bronchus NNS cord-021894-lq8yr710 87 10 that that WDT cord-021894-lq8yr710 87 11 are be VBP cord-021894-lq8yr710 87 12 more more RBR cord-021894-lq8yr710 87 13 likely likely JJ cord-021894-lq8yr710 87 14 to to TO cord-021894-lq8yr710 87 15 become become VB cord-021894-lq8yr710 87 16 blocked block VBN cord-021894-lq8yr710 87 17 by by IN cord-021894-lq8yr710 87 18 secretions secretion NNS cord-021894-lq8yr710 87 19 and and CC cord-021894-lq8yr710 87 20 edema edema NN cord-021894-lq8yr710 87 21 , , , cord-021894-lq8yr710 87 22 and and CC cord-021894-lq8yr710 87 23 a a DT cord-021894-lq8yr710 87 24 less less RBR cord-021894-lq8yr710 87 25 well well RB cord-021894-lq8yr710 87 26 - - HYPH cord-021894-lq8yr710 87 27 developed develop VBN cord-021894-lq8yr710 87 28 ability ability NN cord-021894-lq8yr710 87 29 to to TO cord-021894-lq8yr710 87 30 respond respond VB cord-021894-lq8yr710 87 31 to to IN cord-021894-lq8yr710 87 32 and and CC cord-021894-lq8yr710 87 33 clear clear VB cord-021894-lq8yr710 87 34 viral viral JJ cord-021894-lq8yr710 87 35 infection infection NN cord-021894-lq8yr710 87 36 . . . cord-021894-lq8yr710 88 1 38 38 CD cord-021894-lq8yr710 88 2 Histopathology Histopathology NNP cord-021894-lq8yr710 88 3 is be VBZ cord-021894-lq8yr710 88 4 naturally naturally RB cord-021894-lq8yr710 88 5 limited limit VBN cord-021894-lq8yr710 88 6 to to IN cord-021894-lq8yr710 88 7 the the DT cord-021894-lq8yr710 88 8 most most RBS cord-021894-lq8yr710 88 9 severe severe JJ cord-021894-lq8yr710 88 10 cases case NNS cord-021894-lq8yr710 88 11 who who WP cord-021894-lq8yr710 88 12 have have VBP cord-021894-lq8yr710 88 13 died die VBN cord-021894-lq8yr710 88 14 , , , cord-021894-lq8yr710 88 15 where where WRB cord-021894-lq8yr710 88 16 the the DT cord-021894-lq8yr710 88 17 bronchioles bronchiole NNS cord-021894-lq8yr710 88 18 are be VBP cord-021894-lq8yr710 88 19 edematous edematous JJ cord-021894-lq8yr710 88 20 and and CC cord-021894-lq8yr710 88 21 blocked block VBN cord-021894-lq8yr710 88 22 by by IN cord-021894-lq8yr710 88 23 necrotic necrotic JJ cord-021894-lq8yr710 88 24 epithelium epithelium NN cord-021894-lq8yr710 88 25 and and CC cord-021894-lq8yr710 88 26 neutrophils neutrophil NNS cord-021894-lq8yr710 88 27 , , , cord-021894-lq8yr710 88 28 with with IN cord-021894-lq8yr710 88 29 some some DT cord-021894-lq8yr710 88 30 mucus mucus NN cord-021894-lq8yr710 88 31 binding bind VBG cord-021894-lq8yr710 88 32 this this DT cord-021894-lq8yr710 88 33 debris debris NN cord-021894-lq8yr710 88 34 together together RB cord-021894-lq8yr710 88 35 . . . cord-021894-lq8yr710 89 1 39 39 CD cord-021894-lq8yr710 89 2 Airway airway JJ cord-021894-lq8yr710 89 3 obstruction obstruction NN cord-021894-lq8yr710 89 4 is be VBZ cord-021894-lq8yr710 89 5 intensified intensify VBN cord-021894-lq8yr710 89 6 by by IN cord-021894-lq8yr710 89 7 poor poor JJ cord-021894-lq8yr710 89 8 airway airway NN cord-021894-lq8yr710 89 9 clearance clearance NN cord-021894-lq8yr710 89 10 associated associate VBN cord-021894-lq8yr710 89 11 with with IN cord-021894-lq8yr710 89 12 loss loss NN cord-021894-lq8yr710 89 13 of of IN cord-021894-lq8yr710 89 14 cilia cilia NN cord-021894-lq8yr710 89 15 function function NN cord-021894-lq8yr710 89 16 occurring occur VBG cord-021894-lq8yr710 89 17 within within IN cord-021894-lq8yr710 89 18 24 24 CD cord-021894-lq8yr710 89 19 hours hour NNS cord-021894-lq8yr710 89 20 and and CC cord-021894-lq8yr710 89 21 persisting persist VBG cord-021894-lq8yr710 89 22 for for IN cord-021894-lq8yr710 89 23 up up IN cord-021894-lq8yr710 89 24 to to TO cord-021894-lq8yr710 89 25 3 3 CD cord-021894-lq8yr710 89 26 months month NNS cord-021894-lq8yr710 89 27 after after IN cord-021894-lq8yr710 89 28 the the DT cord-021894-lq8yr710 89 29 illness illness NN cord-021894-lq8yr710 89 30 . . . cord-021894-lq8yr710 90 1 40 40 CD cord-021894-lq8yr710 90 2 Destruction destruction NN cord-021894-lq8yr710 90 3 of of IN cord-021894-lq8yr710 90 4 cilia cilia NN cord-021894-lq8yr710 90 5 is be VBZ cord-021894-lq8yr710 90 6 considered consider VBN cord-021894-lq8yr710 90 7 to to TO cord-021894-lq8yr710 90 8 be be VB cord-021894-lq8yr710 90 9 caused cause VBN cord-021894-lq8yr710 90 10 by by IN cord-021894-lq8yr710 90 11 virus virus NN cord-021894-lq8yr710 90 12 replication replication NN cord-021894-lq8yr710 90 13 and and CC cord-021894-lq8yr710 90 14 not not RB cord-021894-lq8yr710 90 15 mediated mediate VBN cord-021894-lq8yr710 90 16 by by IN cord-021894-lq8yr710 90 17 inflammation inflammation NN cord-021894-lq8yr710 90 18 . . . cord-021894-lq8yr710 91 1 38 38 CD cord-021894-lq8yr710 91 2 RSV RSV NNP cord-021894-lq8yr710 91 3 is be VBZ cord-021894-lq8yr710 91 4 associated associate VBN cord-021894-lq8yr710 91 5 with with IN cord-021894-lq8yr710 91 6 more more RBR cord-021894-lq8yr710 91 7 severe severe JJ cord-021894-lq8yr710 91 8 airway airway NN cord-021894-lq8yr710 91 9 pathology pathology NN cord-021894-lq8yr710 91 10 than than IN cord-021894-lq8yr710 91 11 that that DT cord-021894-lq8yr710 91 12 found find VBN cord-021894-lq8yr710 91 13 in in IN cord-021894-lq8yr710 91 14 children child NNS cord-021894-lq8yr710 91 15 dying die VBG cord-021894-lq8yr710 91 16 from from IN cord-021894-lq8yr710 91 17 other other JJ cord-021894-lq8yr710 91 18 respiratory respiratory JJ cord-021894-lq8yr710 91 19 viruses virus NNS cord-021894-lq8yr710 91 20 , , , cord-021894-lq8yr710 91 21 even even RB cord-021894-lq8yr710 91 22 in in IN cord-021894-lq8yr710 91 23 those those DT cord-021894-lq8yr710 91 24 not not RB cord-021894-lq8yr710 91 25 mechanically mechanically RB cord-021894-lq8yr710 91 26 ventilated ventilate VBN cord-021894-lq8yr710 91 27 . . . cord-021894-lq8yr710 92 1 39 39 CD cord-021894-lq8yr710 92 2 Viral viral JJ cord-021894-lq8yr710 92 3 shedding shedding NN cord-021894-lq8yr710 92 4 is be VBZ cord-021894-lq8yr710 92 5 higher high JJR cord-021894-lq8yr710 92 6 and and CC cord-021894-lq8yr710 92 7 more more RBR cord-021894-lq8yr710 92 8 prolonged prolonged JJ cord-021894-lq8yr710 92 9 in in IN cord-021894-lq8yr710 92 10 younger young JJR cord-021894-lq8yr710 92 11 infants infant NNS cord-021894-lq8yr710 92 12 and and CC cord-021894-lq8yr710 92 13 those those DT cord-021894-lq8yr710 92 14 with with IN cord-021894-lq8yr710 92 15 more more RBR cord-021894-lq8yr710 92 16 severe severe JJ cord-021894-lq8yr710 92 17 disease disease NN cord-021894-lq8yr710 92 18 . . . cord-021894-lq8yr710 93 1 41 41 CD cord-021894-lq8yr710 93 2 Increased increase VBN cord-021894-lq8yr710 93 3 disease disease NN cord-021894-lq8yr710 93 4 severity severity NN cord-021894-lq8yr710 93 5 , , , cord-021894-lq8yr710 93 6 longer long RBR cord-021894-lq8yr710 93 7 hospital hospital NN cord-021894-lq8yr710 93 8 stay stay NN cord-021894-lq8yr710 93 9 and and CC cord-021894-lq8yr710 93 10 use use NN cord-021894-lq8yr710 93 11 of of IN cord-021894-lq8yr710 93 12 intensive intensive JJ cord-021894-lq8yr710 93 13 care care NN cord-021894-lq8yr710 93 14 is be VBZ cord-021894-lq8yr710 93 15 associated associate VBN cord-021894-lq8yr710 93 16 with with IN cord-021894-lq8yr710 93 17 higher high JJR cord-021894-lq8yr710 93 18 viral viral JJ cord-021894-lq8yr710 93 19 load load NN cord-021894-lq8yr710 93 20 for for IN cord-021894-lq8yr710 93 21 RSV RSV NNP cord-021894-lq8yr710 93 22 in in IN cord-021894-lq8yr710 93 23 nasopharyngeal nasopharyngeal JJ cord-021894-lq8yr710 93 24 secretions secretion NNS cord-021894-lq8yr710 93 25 . . . cord-021894-lq8yr710 94 1 42 42 CD cord-021894-lq8yr710 94 2 , , , cord-021894-lq8yr710 94 3 43 43 CD cord-021894-lq8yr710 94 4 Severity severity NN cord-021894-lq8yr710 94 5 of of IN cord-021894-lq8yr710 94 6 disease disease NN cord-021894-lq8yr710 94 7 is be VBZ cord-021894-lq8yr710 94 8 associated associate VBN cord-021894-lq8yr710 94 9 with with IN cord-021894-lq8yr710 94 10 both both DT cord-021894-lq8yr710 94 11 infant infant NN cord-021894-lq8yr710 94 12 risk risk NN cord-021894-lq8yr710 94 13 factors factor NNS cord-021894-lq8yr710 94 14 ( ( -LRB- cord-021894-lq8yr710 94 15 including include VBG cord-021894-lq8yr710 94 16 lack lack NN cord-021894-lq8yr710 94 17 of of IN cord-021894-lq8yr710 94 18 adaptive adaptive JJ cord-021894-lq8yr710 94 19 T T NNP cord-021894-lq8yr710 94 20 cell cell NN cord-021894-lq8yr710 94 21 response response NN cord-021894-lq8yr710 94 22 ) ) -RRB- cord-021894-lq8yr710 94 23 , , , cord-021894-lq8yr710 94 24 26,44 26,44 CD cord-021894-lq8yr710 94 25 but but CC cord-021894-lq8yr710 94 26 also also RB cord-021894-lq8yr710 94 27 RSV RSV NNP cord-021894-lq8yr710 94 28 virus virus NN cord-021894-lq8yr710 94 29 specific specific JJ cord-021894-lq8yr710 94 30 factors factor NNS cord-021894-lq8yr710 94 31 ( ( -LRB- cord-021894-lq8yr710 94 32 viral viral JJ cord-021894-lq8yr710 94 33 antigen antigen NN cord-021894-lq8yr710 94 34 load load NN cord-021894-lq8yr710 94 35 and and CC cord-021894-lq8yr710 94 36 direct direct JJ cord-021894-lq8yr710 94 37 cytotoxic cytotoxic JJ cord-021894-lq8yr710 94 38 effects effect NNS cord-021894-lq8yr710 94 39 ) ) -RRB- cord-021894-lq8yr710 94 40 . . . cord-021894-lq8yr710 95 1 45 45 CD cord-021894-lq8yr710 96 1 Determining determine VBG cord-021894-lq8yr710 96 2 the the DT cord-021894-lq8yr710 96 3 relative relative JJ cord-021894-lq8yr710 96 4 contribution contribution NN cord-021894-lq8yr710 96 5 of of IN cord-021894-lq8yr710 96 6 both both DT cord-021894-lq8yr710 96 7 of of IN cord-021894-lq8yr710 96 8 these these DT cord-021894-lq8yr710 96 9 to to IN cord-021894-lq8yr710 96 10 disease disease NN cord-021894-lq8yr710 96 11 severity severity NN cord-021894-lq8yr710 96 12 will will MD cord-021894-lq8yr710 96 13 be be VB cord-021894-lq8yr710 96 14 important important JJ cord-021894-lq8yr710 96 15 ; ; : cord-021894-lq8yr710 96 16 if if IN cord-021894-lq8yr710 96 17 the the DT cord-021894-lq8yr710 96 18 latter latter NN cord-021894-lq8yr710 96 19 is be VBZ cord-021894-lq8yr710 96 20 dominant dominant JJ cord-021894-lq8yr710 96 21 , , , cord-021894-lq8yr710 96 22 antiviral antiviral JJ cord-021894-lq8yr710 96 23 agents agent NNS cord-021894-lq8yr710 96 24 provided provide VBN cord-021894-lq8yr710 96 25 early early RB cord-021894-lq8yr710 96 26 in in IN cord-021894-lq8yr710 96 27 the the DT cord-021894-lq8yr710 96 28 course course NN cord-021894-lq8yr710 96 29 of of IN cord-021894-lq8yr710 96 30 the the DT cord-021894-lq8yr710 96 31 disease disease NN cord-021894-lq8yr710 96 32 may may MD cord-021894-lq8yr710 96 33 reduce reduce VB cord-021894-lq8yr710 96 34 severity severity NN cord-021894-lq8yr710 96 35 , , , cord-021894-lq8yr710 96 36 whereas whereas IN cord-021894-lq8yr710 96 37 dominance dominance NN cord-021894-lq8yr710 96 38 of of IN cord-021894-lq8yr710 96 39 the the DT cord-021894-lq8yr710 96 40 former former JJ cord-021894-lq8yr710 96 41 might may MD cord-021894-lq8yr710 96 42 need need VB cord-021894-lq8yr710 96 43 additional additional JJ cord-021894-lq8yr710 96 44 immunomodulators immunomodulator NNS cord-021894-lq8yr710 96 45 . . . cord-021894-lq8yr710 97 1 4 4 LS cord-021894-lq8yr710 97 2 Biomarkers biomarker NNS cord-021894-lq8yr710 97 3 are be VBP cord-021894-lq8yr710 97 4 now now RB cord-021894-lq8yr710 97 5 sought seek VBN cord-021894-lq8yr710 97 6 to to TO cord-021894-lq8yr710 97 7 better better RB cord-021894-lq8yr710 97 8 characterize characterize VB cord-021894-lq8yr710 97 9 those those DT cord-021894-lq8yr710 97 10 at at IN cord-021894-lq8yr710 97 11 risk risk NN cord-021894-lq8yr710 97 12 of of IN cord-021894-lq8yr710 97 13 greater great JJR cord-021894-lq8yr710 97 14 disease disease NN cord-021894-lq8yr710 97 15 severity severity NN cord-021894-lq8yr710 97 16 and and CC cord-021894-lq8yr710 97 17 to to TO cord-021894-lq8yr710 97 18 indicate indicate VB cord-021894-lq8yr710 97 19 recovery recovery NN cord-021894-lq8yr710 97 20 . . . cord-021894-lq8yr710 98 1 Infants infant NNS cord-021894-lq8yr710 98 2 hospitalized hospitalize VBN cord-021894-lq8yr710 98 3 with with IN cord-021894-lq8yr710 98 4 RSV RSV NNP cord-021894-lq8yr710 98 5 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 98 6 have have VBP cord-021894-lq8yr710 98 7 increased increase VBN cord-021894-lq8yr710 98 8 interleukin interleukin NN cord-021894-lq8yr710 98 9 ( ( -LRB- cord-021894-lq8yr710 98 10 IL)-33 il)-33 NN cord-021894-lq8yr710 98 11 and and CC cord-021894-lq8yr710 98 12 IL-13 IL-13 NNP cord-021894-lq8yr710 98 13 in in IN cord-021894-lq8yr710 98 14 secretions secretion NNS cord-021894-lq8yr710 98 15 . . . cord-021894-lq8yr710 99 1 46 46 CD cord-021894-lq8yr710 99 2 Polymorphisms polymorphism NNS cord-021894-lq8yr710 99 3 of of IN cord-021894-lq8yr710 99 4 surfactant surfactant NN cord-021894-lq8yr710 99 5 protein protein NN cord-021894-lq8yr710 99 6 A A NNP cord-021894-lq8yr710 99 7 are be VBP cord-021894-lq8yr710 99 8 associated associate VBN cord-021894-lq8yr710 99 9 with with IN cord-021894-lq8yr710 99 10 increased increase VBN cord-021894-lq8yr710 99 11 risk risk NN cord-021894-lq8yr710 99 12 of of IN cord-021894-lq8yr710 99 13 intensive intensive JJ cord-021894-lq8yr710 99 14 care care NN cord-021894-lq8yr710 99 15 admission admission NN cord-021894-lq8yr710 99 16 . . . cord-021894-lq8yr710 100 1 47 47 CD cord-021894-lq8yr710 100 2 Cysteinyl Cysteinyl NNP cord-021894-lq8yr710 100 3 leukotrienes leukotriene NNS cord-021894-lq8yr710 100 4 are be VBP cord-021894-lq8yr710 100 5 increased increase VBN cord-021894-lq8yr710 100 6 in in IN cord-021894-lq8yr710 100 7 infants infant NNS cord-021894-lq8yr710 100 8 with with IN cord-021894-lq8yr710 100 9 RSV RSV NNP cord-021894-lq8yr710 100 10 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 100 11 and and CC cord-021894-lq8yr710 100 12 are be VBP cord-021894-lq8yr710 100 13 still still RB cord-021894-lq8yr710 100 14 increased increase VBN cord-021894-lq8yr710 100 15 1 1 CD cord-021894-lq8yr710 100 16 month month NN cord-021894-lq8yr710 100 17 following follow VBG cord-021894-lq8yr710 100 18 infection infection NN cord-021894-lq8yr710 100 19 . . . cord-021894-lq8yr710 101 1 48 48 CD cord-021894-lq8yr710 101 2 More More JJR cord-021894-lq8yr710 101 3 severe severe JJ cord-021894-lq8yr710 101 4 disease disease NN cord-021894-lq8yr710 101 5 is be VBZ cord-021894-lq8yr710 101 6 also also RB cord-021894-lq8yr710 101 7 associated associate VBN cord-021894-lq8yr710 101 8 with with IN cord-021894-lq8yr710 101 9 increased increase VBN cord-021894-lq8yr710 101 10 serum serum NN cord-021894-lq8yr710 101 11 cathelicidin cathelicidin NNS cord-021894-lq8yr710 101 12 , , , cord-021894-lq8yr710 101 13 49 49 CD cord-021894-lq8yr710 101 14 lactate lactate NN cord-021894-lq8yr710 101 15 dehydrogenase dehydrogenase NN cord-021894-lq8yr710 101 16 , , , cord-021894-lq8yr710 101 17 caspase caspase NN cord-021894-lq8yr710 101 18 50 50 CD cord-021894-lq8yr710 101 19 and and CC cord-021894-lq8yr710 101 20 IL-15 IL-15 NNP cord-021894-lq8yr710 101 21 . . . cord-021894-lq8yr710 102 1 51 51 CD cord-021894-lq8yr710 103 1 There there EX cord-021894-lq8yr710 103 2 is be VBZ cord-021894-lq8yr710 103 3 some some DT cord-021894-lq8yr710 103 4 evidence evidence NN cord-021894-lq8yr710 103 5 that that IN cord-021894-lq8yr710 103 6 more more RBR cord-021894-lq8yr710 103 7 severe severe JJ cord-021894-lq8yr710 103 8 disease disease NN cord-021894-lq8yr710 103 9 may may MD cord-021894-lq8yr710 103 10 be be VB cord-021894-lq8yr710 103 11 associated associate VBN cord-021894-lq8yr710 103 12 with with IN cord-021894-lq8yr710 103 13 an an DT cord-021894-lq8yr710 103 14 insufficient insufficient JJ cord-021894-lq8yr710 103 15 inflammatory inflammatory JJ cord-021894-lq8yr710 103 16 response response NN cord-021894-lq8yr710 103 17 . . . cord-021894-lq8yr710 104 1 52 52 CD cord-021894-lq8yr710 105 1 The the DT cord-021894-lq8yr710 105 2 interrelationship interrelationship NN cord-021894-lq8yr710 105 3 of of IN cord-021894-lq8yr710 105 4 the the DT cord-021894-lq8yr710 105 5 microbiome microbiome NN cord-021894-lq8yr710 105 6 in in IN cord-021894-lq8yr710 105 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 105 8 is be VBZ cord-021894-lq8yr710 105 9 also also RB cord-021894-lq8yr710 105 10 being be VBG cord-021894-lq8yr710 105 11 actively actively RB cord-021894-lq8yr710 105 12 explored explore VBN cord-021894-lq8yr710 105 13 . . . cord-021894-lq8yr710 106 1 53 53 CD cord-021894-lq8yr710 106 2 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 106 3 is be VBZ cord-021894-lq8yr710 106 4 diagnosed diagnose VBN cord-021894-lq8yr710 106 5 clinically clinically RB cord-021894-lq8yr710 106 6 . . . cord-021894-lq8yr710 107 1 Variance variance NN cord-021894-lq8yr710 107 2 in in IN cord-021894-lq8yr710 107 3 the the DT cord-021894-lq8yr710 107 4 clinical clinical JJ cord-021894-lq8yr710 107 5 interpretation interpretation NN cord-021894-lq8yr710 107 6 of of IN cord-021894-lq8yr710 107 7 symptoms symptom NNS cord-021894-lq8yr710 107 8 and and CC cord-021894-lq8yr710 107 9 physical physical JJ cord-021894-lq8yr710 107 10 findings finding NNS cord-021894-lq8yr710 107 11 lead lead VBP cord-021894-lq8yr710 107 12 to to IN cord-021894-lq8yr710 107 13 inconsistency inconsistency NN cord-021894-lq8yr710 107 14 in in IN cord-021894-lq8yr710 107 15 diagnosis diagnosis NN cord-021894-lq8yr710 107 16 , , , cord-021894-lq8yr710 107 17 particularly particularly RB cord-021894-lq8yr710 107 18 in in IN cord-021894-lq8yr710 107 19 milder mild JJR cord-021894-lq8yr710 107 20 cases case NNS cord-021894-lq8yr710 107 21 and and CC cord-021894-lq8yr710 107 22 children child NNS cord-021894-lq8yr710 107 23 over over IN cord-021894-lq8yr710 107 24 1 1 CD cord-021894-lq8yr710 107 25 year year NN cord-021894-lq8yr710 107 26 of of IN cord-021894-lq8yr710 107 27 age age NN cord-021894-lq8yr710 107 28 . . . cord-021894-lq8yr710 108 1 Typical typical JJ cord-021894-lq8yr710 108 2 symptoms symptom NNS cord-021894-lq8yr710 108 3 are be VBP cord-021894-lq8yr710 108 4 rhinorrhea rhinorrhea NNP cord-021894-lq8yr710 108 5 , , , cord-021894-lq8yr710 108 6 proceeding proceed VBG cord-021894-lq8yr710 108 7 over over IN cord-021894-lq8yr710 108 8 2 2 CD cord-021894-lq8yr710 108 9 to to TO cord-021894-lq8yr710 108 10 4 4 CD cord-021894-lq8yr710 108 11 days day NNS cord-021894-lq8yr710 108 12 to to IN cord-021894-lq8yr710 108 13 a a DT cord-021894-lq8yr710 108 14 characteristic characteristic JJ cord-021894-lq8yr710 108 15 harsh harsh JJ cord-021894-lq8yr710 108 16 moist moist JJ cord-021894-lq8yr710 108 17 cough cough NN cord-021894-lq8yr710 108 18 with with IN cord-021894-lq8yr710 108 19 pyrexia pyrexia NN cord-021894-lq8yr710 108 20 that that WDT cord-021894-lq8yr710 108 21 is be VBZ cord-021894-lq8yr710 108 22 typically typically RB cord-021894-lq8yr710 108 23 below below IN cord-021894-lq8yr710 108 24 39 39 CD cord-021894-lq8yr710 108 25 ° ° NN cord-021894-lq8yr710 108 26 C c NN cord-021894-lq8yr710 108 27 , , , cord-021894-lq8yr710 108 28 although although IN cord-021894-lq8yr710 108 29 fever fever NN cord-021894-lq8yr710 108 30 above above IN cord-021894-lq8yr710 108 31 38.5 38.5 CD cord-021894-lq8yr710 108 32 ° ° NN cord-021894-lq8yr710 108 33 C c NN cord-021894-lq8yr710 108 34 is be VBZ cord-021894-lq8yr710 108 35 seen see VBN cord-021894-lq8yr710 108 36 in in IN cord-021894-lq8yr710 108 37 50 50 CD cord-021894-lq8yr710 108 38 % % NN cord-021894-lq8yr710 108 39 of of IN cord-021894-lq8yr710 108 40 infants infant NNS cord-021894-lq8yr710 108 41 . . . cord-021894-lq8yr710 109 1 54 54 CD cord-021894-lq8yr710 109 2 Ability ability NN cord-021894-lq8yr710 109 3 to to TO cord-021894-lq8yr710 109 4 achieve achieve VB cord-021894-lq8yr710 109 5 adequate adequate JJ cord-021894-lq8yr710 109 6 oral oral JJ cord-021894-lq8yr710 109 7 feeding feeding NN cord-021894-lq8yr710 109 8 declines decline NNS cord-021894-lq8yr710 109 9 as as IN cord-021894-lq8yr710 109 10 nasal nasal JJ cord-021894-lq8yr710 109 11 obstruction obstruction NN cord-021894-lq8yr710 109 12 with with IN cord-021894-lq8yr710 109 13 secretions secretion NNS cord-021894-lq8yr710 109 14 develops develop VBZ cord-021894-lq8yr710 109 15 and and CC cord-021894-lq8yr710 109 16 work work NN cord-021894-lq8yr710 109 17 of of IN cord-021894-lq8yr710 109 18 breathing breathing NN cord-021894-lq8yr710 109 19 increases increase NNS cord-021894-lq8yr710 109 20 . . . cord-021894-lq8yr710 110 1 The the DT cord-021894-lq8yr710 110 2 time time NN cord-021894-lq8yr710 110 3 to to TO cord-021894-lq8yr710 110 4 peak peak VB cord-021894-lq8yr710 110 5 symptoms symptom NNS cord-021894-lq8yr710 110 6 of of IN cord-021894-lq8yr710 110 7 4 4 CD cord-021894-lq8yr710 110 8 days day NNS cord-021894-lq8yr710 110 9 is be VBZ cord-021894-lq8yr710 110 10 associated associate VBN cord-021894-lq8yr710 110 11 with with IN cord-021894-lq8yr710 110 12 the the DT cord-021894-lq8yr710 110 13 peak peak NN cord-021894-lq8yr710 110 14 in in IN cord-021894-lq8yr710 110 15 viral viral JJ cord-021894-lq8yr710 110 16 load load NN cord-021894-lq8yr710 110 17 , , , cord-021894-lq8yr710 110 18 42 42 CD cord-021894-lq8yr710 110 19 , , , cord-021894-lq8yr710 110 20 55 55 CD cord-021894-lq8yr710 110 21 varying vary VBG cord-021894-lq8yr710 110 22 from from IN cord-021894-lq8yr710 110 23 infant infant NN cord-021894-lq8yr710 110 24 to to IN cord-021894-lq8yr710 110 25 infant infant NN cord-021894-lq8yr710 110 26 . . . cord-021894-lq8yr710 111 1 In in IN cord-021894-lq8yr710 111 2 younger young JJR cord-021894-lq8yr710 111 3 children child NNS cord-021894-lq8yr710 111 4 ( ( -LRB- cord-021894-lq8yr710 111 5 particularly particularly RB cord-021894-lq8yr710 111 6 < < XX cord-021894-lq8yr710 111 7 6 6 CD cord-021894-lq8yr710 111 8 weeks week NNS cord-021894-lq8yr710 111 9 of of IN cord-021894-lq8yr710 111 10 age age NN cord-021894-lq8yr710 111 11 ) ) -RRB- cord-021894-lq8yr710 111 12 , , , cord-021894-lq8yr710 111 13 apnea apnea NN cord-021894-lq8yr710 111 14 may may MD cord-021894-lq8yr710 111 15 be be VB cord-021894-lq8yr710 111 16 a a DT cord-021894-lq8yr710 111 17 presenting present VBG cord-021894-lq8yr710 111 18 sign sign NN cord-021894-lq8yr710 111 19 , , , cord-021894-lq8yr710 111 20 sometimes sometimes RB cord-021894-lq8yr710 111 21 in in IN cord-021894-lq8yr710 111 22 the the DT cord-021894-lq8yr710 111 23 absence absence NN cord-021894-lq8yr710 111 24 of of IN cord-021894-lq8yr710 111 25 other other JJ cord-021894-lq8yr710 111 26 features feature NNS cord-021894-lq8yr710 111 27 of of IN cord-021894-lq8yr710 111 28 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 111 29 . . . cord-021894-lq8yr710 112 1 Apnea apnea NN cord-021894-lq8yr710 112 2 may may MD cord-021894-lq8yr710 112 3 be be VB cord-021894-lq8yr710 112 4 temporarily temporarily RB cord-021894-lq8yr710 112 5 improved improve VBN cord-021894-lq8yr710 112 6 by by IN cord-021894-lq8yr710 112 7 nasal nasal NN cord-021894-lq8yr710 112 8 suctioning suctioning NN cord-021894-lq8yr710 112 9 , , , cord-021894-lq8yr710 112 10 but but CC cord-021894-lq8yr710 112 11 it -PRON- PRP cord-021894-lq8yr710 112 12 is be VBZ cord-021894-lq8yr710 112 13 most most RBS cord-021894-lq8yr710 112 14 likely likely RB cord-021894-lq8yr710 112 15 a a DT cord-021894-lq8yr710 112 16 direct direct JJ cord-021894-lq8yr710 112 17 viral viral JJ cord-021894-lq8yr710 112 18 effect effect NN cord-021894-lq8yr710 112 19 in in IN cord-021894-lq8yr710 112 20 young young JJ cord-021894-lq8yr710 112 21 infants infant NNS cord-021894-lq8yr710 112 22 . . . cord-021894-lq8yr710 113 1 56 56 CD cord-021894-lq8yr710 113 2 Apnea apnea NN cord-021894-lq8yr710 113 3 is be VBZ cord-021894-lq8yr710 113 4 a a DT cord-021894-lq8yr710 113 5 " " `` cord-021894-lq8yr710 113 6 red red JJ cord-021894-lq8yr710 113 7 flag flag NN cord-021894-lq8yr710 113 8 " " '' cord-021894-lq8yr710 113 9 sign sign NN cord-021894-lq8yr710 113 10 in in IN cord-021894-lq8yr710 113 11 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 113 12 that that WDT cord-021894-lq8yr710 113 13 warrants warrant VBZ cord-021894-lq8yr710 113 14 a a DT cord-021894-lq8yr710 113 15 period period NN cord-021894-lq8yr710 113 16 of of IN cord-021894-lq8yr710 113 17 review review NN cord-021894-lq8yr710 113 18 in in IN cord-021894-lq8yr710 113 19 a a DT cord-021894-lq8yr710 113 20 supervised supervise VBN cord-021894-lq8yr710 113 21 clinical clinical JJ cord-021894-lq8yr710 113 22 setting setting NN cord-021894-lq8yr710 113 23 to to TO cord-021894-lq8yr710 113 24 ensure ensure VB cord-021894-lq8yr710 113 25 that that IN cord-021894-lq8yr710 113 26 it -PRON- PRP cord-021894-lq8yr710 113 27 has have VBZ cord-021894-lq8yr710 113 28 resolved resolve VBN cord-021894-lq8yr710 113 29 . . . cord-021894-lq8yr710 114 1 Patients patient NNS cord-021894-lq8yr710 114 2 more more RBR cord-021894-lq8yr710 114 3 likely likely JJ cord-021894-lq8yr710 114 4 to to TO cord-021894-lq8yr710 114 5 require require VB cord-021894-lq8yr710 114 6 intensive intensive JJ cord-021894-lq8yr710 114 7 care care NN cord-021894-lq8yr710 114 8 include include VBP cord-021894-lq8yr710 114 9 preterm preterm JJR cord-021894-lq8yr710 114 10 infants infant NNS cord-021894-lq8yr710 114 11 and and CC cord-021894-lq8yr710 114 12 those those DT cord-021894-lq8yr710 114 13 with with IN cord-021894-lq8yr710 114 14 apnea apnea NN cord-021894-lq8yr710 114 15 , , , cord-021894-lq8yr710 114 16 low low JJ cord-021894-lq8yr710 114 17 birth birth NN cord-021894-lq8yr710 114 18 weight weight NN cord-021894-lq8yr710 114 19 , , , cord-021894-lq8yr710 114 20 or or CC cord-021894-lq8yr710 114 21 a a DT cord-021894-lq8yr710 114 22 respiratory respiratory JJ cord-021894-lq8yr710 114 23 rate rate NN cord-021894-lq8yr710 114 24 greater great JJR cord-021894-lq8yr710 114 25 than than IN cord-021894-lq8yr710 114 26 70 70 CD cord-021894-lq8yr710 114 27 / / SYM cord-021894-lq8yr710 114 28 min min NN cord-021894-lq8yr710 114 29 . . . cord-021894-lq8yr710 115 1 57 57 CD cord-021894-lq8yr710 115 2 , , , cord-021894-lq8yr710 115 3 58 58 CD cord-021894-lq8yr710 115 4 Children child NNS cord-021894-lq8yr710 115 5 tend tend VBP cord-021894-lq8yr710 115 6 not not RB cord-021894-lq8yr710 115 7 to to TO cord-021894-lq8yr710 115 8 relapse relapse VB cord-021894-lq8yr710 115 9 during during IN cord-021894-lq8yr710 115 10 the the DT cord-021894-lq8yr710 115 11 improving improve VBG cord-021894-lq8yr710 115 12 phase phase NN cord-021894-lq8yr710 115 13 of of IN cord-021894-lq8yr710 115 14 the the DT cord-021894-lq8yr710 115 15 illness illness NN cord-021894-lq8yr710 115 16 , , , cord-021894-lq8yr710 115 17 which which WDT cord-021894-lq8yr710 115 18 should should MD cord-021894-lq8yr710 115 19 give give VB cord-021894-lq8yr710 115 20 confidence confidence NN cord-021894-lq8yr710 115 21 to to IN cord-021894-lq8yr710 115 22 clinicians clinician NNS cord-021894-lq8yr710 115 23 when when WRB cord-021894-lq8yr710 115 24 considering consider VBG cord-021894-lq8yr710 115 25 discharge discharge NN cord-021894-lq8yr710 115 26 from from IN cord-021894-lq8yr710 115 27 ED ED NNP cord-021894-lq8yr710 115 28 or or CC cord-021894-lq8yr710 115 29 hospital hospital NN cord-021894-lq8yr710 115 30 . . . cord-021894-lq8yr710 116 1 58 58 CD cord-021894-lq8yr710 116 2 , , , cord-021894-lq8yr710 116 3 59 59 CD cord-021894-lq8yr710 116 4 _SP cord-021894-lq8yr710 116 5 Physical physical JJ cord-021894-lq8yr710 116 6 findings finding NNS cord-021894-lq8yr710 116 7 include include VBP cord-021894-lq8yr710 116 8 an an DT cord-021894-lq8yr710 116 9 increased increase VBN cord-021894-lq8yr710 116 10 respiratory respiratory JJ cord-021894-lq8yr710 116 11 rate rate NN cord-021894-lq8yr710 116 12 , , , cord-021894-lq8yr710 116 13 chest chest NN cord-021894-lq8yr710 116 14 recession recession NN cord-021894-lq8yr710 116 15 , , , cord-021894-lq8yr710 116 16 use use NN cord-021894-lq8yr710 116 17 of of IN cord-021894-lq8yr710 116 18 accessory accessory NN cord-021894-lq8yr710 116 19 muscles muscle NNS cord-021894-lq8yr710 116 20 , , , cord-021894-lq8yr710 116 21 hyperinflation hyperinflation NN cord-021894-lq8yr710 116 22 , , , cord-021894-lq8yr710 116 23 wheezing wheezing NN cord-021894-lq8yr710 116 24 , , , cord-021894-lq8yr710 116 25 crackles crackle NNS cord-021894-lq8yr710 116 26 , , , cord-021894-lq8yr710 116 27 and and CC cord-021894-lq8yr710 116 28 reduced reduce VBN cord-021894-lq8yr710 116 29 arterial arterial JJ cord-021894-lq8yr710 116 30 oxygen oxygen NN cord-021894-lq8yr710 116 31 saturations saturation NNS cord-021894-lq8yr710 116 32 . . . cord-021894-lq8yr710 117 1 60 60 CD cord-021894-lq8yr710 117 2 Physical physical JJ cord-021894-lq8yr710 117 3 findings finding NNS cord-021894-lq8yr710 117 4 vary vary VBP cord-021894-lq8yr710 117 5 depending depend VBG cord-021894-lq8yr710 117 6 on on IN cord-021894-lq8yr710 117 7 sleep sleep NN cord-021894-lq8yr710 117 8 state state NN cord-021894-lq8yr710 117 9 ( ( -LRB- cord-021894-lq8yr710 117 10 and and CC cord-021894-lq8yr710 117 11 associated associate VBN cord-021894-lq8yr710 117 12 changes change NNS cord-021894-lq8yr710 117 13 in in IN cord-021894-lq8yr710 117 14 tidal tidal JJ cord-021894-lq8yr710 117 15 volume volume NN cord-021894-lq8yr710 117 16 ) ) -RRB- cord-021894-lq8yr710 117 17 . . . cord-021894-lq8yr710 118 1 Respiratory respiratory JJ cord-021894-lq8yr710 118 2 rate rate NN cord-021894-lq8yr710 118 3 is be VBZ cord-021894-lq8yr710 118 4 a a DT cord-021894-lq8yr710 118 5 key key JJ cord-021894-lq8yr710 118 6 marker marker NN cord-021894-lq8yr710 118 7 of of IN cord-021894-lq8yr710 118 8 disease disease NN cord-021894-lq8yr710 118 9 severity severity NN cord-021894-lq8yr710 118 10 , , , cord-021894-lq8yr710 118 11 with with IN cord-021894-lq8yr710 118 12 ≥60 ≥60 NNP cord-021894-lq8yr710 118 13 / / SYM cord-021894-lq8yr710 118 14 min min NN cord-021894-lq8yr710 118 15 considered consider VBN cord-021894-lq8yr710 118 16 severe severe JJ cord-021894-lq8yr710 118 17 and and CC cord-021894-lq8yr710 118 18 ≥70/ ≥70/ NN cord-021894-lq8yr710 118 19 min min NN cord-021894-lq8yr710 118 20 critical critical JJ cord-021894-lq8yr710 118 21 . . . cord-021894-lq8yr710 119 1 26 26 CD cord-021894-lq8yr710 119 2 , , , cord-021894-lq8yr710 119 3 61 61 CD cord-021894-lq8yr710 119 4 Oxygen oxygen NN cord-021894-lq8yr710 119 5 saturation saturation NN cord-021894-lq8yr710 119 6 may may MD cord-021894-lq8yr710 119 7 be be VB cord-021894-lq8yr710 119 8 improved improve VBN cord-021894-lq8yr710 119 9 ( ( -LRB- cord-021894-lq8yr710 119 10 at at IN cord-021894-lq8yr710 119 11 least least JJS cord-021894-lq8yr710 119 12 temporarily temporarily RB cord-021894-lq8yr710 119 13 ) ) -RRB- cord-021894-lq8yr710 119 14 by by IN cord-021894-lq8yr710 119 15 removal removal NN cord-021894-lq8yr710 119 16 of of IN cord-021894-lq8yr710 119 17 nasal nasal JJ cord-021894-lq8yr710 119 18 secretions secretion NNS cord-021894-lq8yr710 119 19 . . . cord-021894-lq8yr710 120 1 62 62 CD cord-021894-lq8yr710 121 1 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 121 2 is be VBZ cord-021894-lq8yr710 121 3 a a DT cord-021894-lq8yr710 121 4 highly highly RB cord-021894-lq8yr710 121 5 variable variable JJ cord-021894-lq8yr710 121 6 disease disease NN cord-021894-lq8yr710 121 7 that that WDT cord-021894-lq8yr710 121 8 requires require VBZ cord-021894-lq8yr710 121 9 assessment assessment NN cord-021894-lq8yr710 121 10 of of IN cord-021894-lq8yr710 121 11 disease disease NN cord-021894-lq8yr710 121 12 severity severity NN cord-021894-lq8yr710 121 13 by by IN cord-021894-lq8yr710 121 14 clinicians clinician NNS cord-021894-lq8yr710 121 15 for for IN cord-021894-lq8yr710 121 16 decision decision NN cord-021894-lq8yr710 121 17 making making NN cord-021894-lq8yr710 121 18 , , , cord-021894-lq8yr710 121 19 some some DT cord-021894-lq8yr710 121 20 of of IN cord-021894-lq8yr710 121 21 which which WDT cord-021894-lq8yr710 121 22 is be VBZ cord-021894-lq8yr710 121 23 subjective subjective JJ cord-021894-lq8yr710 121 24 . . . cord-021894-lq8yr710 122 1 Clinical clinical JJ cord-021894-lq8yr710 122 2 scoring scoring NN cord-021894-lq8yr710 122 3 systems system NNS cord-021894-lq8yr710 122 4 have have VBP cord-021894-lq8yr710 122 5 been be VBN cord-021894-lq8yr710 122 6 developed develop VBN cord-021894-lq8yr710 122 7 in in IN cord-021894-lq8yr710 122 8 an an DT cord-021894-lq8yr710 122 9 attempt attempt NN cord-021894-lq8yr710 122 10 to to TO cord-021894-lq8yr710 122 11 standardize standardize VB cord-021894-lq8yr710 122 12 care care NN cord-021894-lq8yr710 122 13 and and CC cord-021894-lq8yr710 122 14 minimize minimize VB cord-021894-lq8yr710 122 15 variance variance NN cord-021894-lq8yr710 122 16 . . . cord-021894-lq8yr710 123 1 Many many JJ cord-021894-lq8yr710 123 2 early early JJ cord-021894-lq8yr710 123 3 scores score NNS cord-021894-lq8yr710 123 4 derived derive VBN cord-021894-lq8yr710 123 5 from from IN cord-021894-lq8yr710 123 6 asthma asthma NN cord-021894-lq8yr710 123 7 scores score NNS cord-021894-lq8yr710 123 8 . . . cord-021894-lq8yr710 124 1 The the DT cord-021894-lq8yr710 124 2 most most RBS cord-021894-lq8yr710 124 3 commonly commonly RB cord-021894-lq8yr710 124 4 applied apply VBD cord-021894-lq8yr710 124 5 scores score NNS cord-021894-lq8yr710 124 6 for for IN cord-021894-lq8yr710 124 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 124 8 are be VBP cord-021894-lq8yr710 124 9 outlined outline VBN cord-021894-lq8yr710 124 10 in in IN cord-021894-lq8yr710 124 11 65 65 CD cord-021894-lq8yr710 124 12 ) ) -RRB- cord-021894-lq8yr710 124 13 and and CC cord-021894-lq8yr710 124 14 to to TO cord-021894-lq8yr710 124 15 improve improve VB cord-021894-lq8yr710 124 16 the the DT cord-021894-lq8yr710 124 17 ability ability NN cord-021894-lq8yr710 124 18 to to TO cord-021894-lq8yr710 124 19 identify identify VB cord-021894-lq8yr710 124 20 those those DT cord-021894-lq8yr710 124 21 at at IN cord-021894-lq8yr710 124 22 risk risk NN cord-021894-lq8yr710 124 23 of of IN cord-021894-lq8yr710 124 24 deterioration deterioration NN cord-021894-lq8yr710 124 25 . . . cord-021894-lq8yr710 125 1 The the DT cord-021894-lq8yr710 125 2 ability ability NN cord-021894-lq8yr710 125 3 of of IN cord-021894-lq8yr710 125 4 clinical clinical JJ cord-021894-lq8yr710 125 5 scores score NNS cord-021894-lq8yr710 125 6 to to TO cord-021894-lq8yr710 125 7 retain retain VB cord-021894-lq8yr710 125 8 precision precision NN cord-021894-lq8yr710 125 9 and and CC cord-021894-lq8yr710 125 10 reliability reliability NN cord-021894-lq8yr710 125 11 , , , cord-021894-lq8yr710 125 12 when when WRB cord-021894-lq8yr710 125 13 scoring scoring NN cord-021894-lq8yr710 125 14 is be VBZ cord-021894-lq8yr710 125 15 performed perform VBN cord-021894-lq8yr710 125 16 by by IN cord-021894-lq8yr710 125 17 larger large JJR cord-021894-lq8yr710 125 18 numbers number NNS cord-021894-lq8yr710 125 19 of of IN cord-021894-lq8yr710 125 20 health health NN cord-021894-lq8yr710 125 21 care care NN cord-021894-lq8yr710 125 22 professionals professional NNS cord-021894-lq8yr710 125 23 in in IN cord-021894-lq8yr710 125 24 the the DT cord-021894-lq8yr710 125 25 context context NN cord-021894-lq8yr710 125 26 of of IN cord-021894-lq8yr710 125 27 multicenter multicenter JJ cord-021894-lq8yr710 125 28 Phase Phase NNP cord-021894-lq8yr710 125 29 III iii CD cord-021894-lq8yr710 125 30 trials trial NNS cord-021894-lq8yr710 125 31 , , , cord-021894-lq8yr710 125 32 is be VBZ cord-021894-lq8yr710 125 33 of of IN cord-021894-lq8yr710 125 34 current current JJ cord-021894-lq8yr710 125 35 interest interest NN cord-021894-lq8yr710 125 36 . . . cord-021894-lq8yr710 126 1 Symptoms symptom NNS cord-021894-lq8yr710 126 2 in in IN cord-021894-lq8yr710 126 3 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 126 4 vary vary VBP cord-021894-lq8yr710 126 5 across across IN cord-021894-lq8yr710 126 6 a a DT cord-021894-lq8yr710 126 7 wide wide JJ cord-021894-lq8yr710 126 8 but but CC cord-021894-lq8yr710 126 9 skewed skewed JJ cord-021894-lq8yr710 126 10 continuum continuum NN cord-021894-lq8yr710 126 11 from from IN cord-021894-lq8yr710 126 12 mildly mildly RB cord-021894-lq8yr710 126 13 increased increase VBN cord-021894-lq8yr710 126 14 work work NN cord-021894-lq8yr710 126 15 of of IN cord-021894-lq8yr710 126 16 breathing breathe VBG cord-021894-lq8yr710 126 17 with with IN cord-021894-lq8yr710 126 18 cough cough NN cord-021894-lq8yr710 126 19 to to IN cord-021894-lq8yr710 126 20 respiratory respiratory JJ cord-021894-lq8yr710 126 21 failure failure NN cord-021894-lq8yr710 126 22 and and CC cord-021894-lq8yr710 126 23 death death NN cord-021894-lq8yr710 126 24 . . . cord-021894-lq8yr710 127 1 Often often RB cord-021894-lq8yr710 127 2 divided divide VBN cord-021894-lq8yr710 127 3 into into IN cord-021894-lq8yr710 127 4 mild mild JJ cord-021894-lq8yr710 127 5 , , , cord-021894-lq8yr710 127 6 moderate moderate JJ cord-021894-lq8yr710 127 7 , , , cord-021894-lq8yr710 127 8 and and CC cord-021894-lq8yr710 127 9 severe severe JJ cord-021894-lq8yr710 127 10 disease disease NN cord-021894-lq8yr710 127 11 , , , cord-021894-lq8yr710 127 12 the the DT cord-021894-lq8yr710 127 13 perspective perspective NN cord-021894-lq8yr710 127 14 on on IN cord-021894-lq8yr710 127 15 these these DT cord-021894-lq8yr710 127 16 gradations gradation NNS cord-021894-lq8yr710 127 17 varies vary VBZ cord-021894-lq8yr710 127 18 across across IN cord-021894-lq8yr710 127 19 health health NN cord-021894-lq8yr710 127 20 care care NN cord-021894-lq8yr710 127 21 systems system NNS cord-021894-lq8yr710 127 22 . . . cord-021894-lq8yr710 128 1 A a DT cord-021894-lq8yr710 128 2 World World NNP cord-021894-lq8yr710 128 3 Health Health NNP cord-021894-lq8yr710 128 4 Organization Organization NNP cord-021894-lq8yr710 128 5 ( ( -LRB- cord-021894-lq8yr710 128 6 WHO who WP cord-021894-lq8yr710 128 7 ) ) -RRB- cord-021894-lq8yr710 128 8 workshop workshop NN cord-021894-lq8yr710 128 9 has have VBZ cord-021894-lq8yr710 128 10 provided provide VBN cord-021894-lq8yr710 128 11 candidate candidate NN cord-021894-lq8yr710 128 12 definitions definition NNS cord-021894-lq8yr710 128 13 differentiating differentiate VBG cord-021894-lq8yr710 128 14 a a DT cord-021894-lq8yr710 128 15 diagnosis diagnosis NN cord-021894-lq8yr710 128 16 of of IN cord-021894-lq8yr710 128 17 RSV RSV NNP cord-021894-lq8yr710 128 18 lower low JJR cord-021894-lq8yr710 128 19 respiratory respiratory JJ cord-021894-lq8yr710 128 20 tract tract NN cord-021894-lq8yr710 128 21 infection infection NN cord-021894-lq8yr710 128 22 ( ( -LRB- cord-021894-lq8yr710 128 23 SpO SpO NNP cord-021894-lq8yr710 128 24 2 2 CD cord-021894-lq8yr710 128 25 < < XX cord-021894-lq8yr710 128 26 95 95 CD cord-021894-lq8yr710 128 27 % % NN cord-021894-lq8yr710 128 28 ) ) -RRB- cord-021894-lq8yr710 128 29 from from IN cord-021894-lq8yr710 128 30 severe severe JJ cord-021894-lq8yr710 128 31 ( ( -LRB- cord-021894-lq8yr710 128 32 < < XX cord-021894-lq8yr710 128 33 93 93 CD cord-021894-lq8yr710 128 34 % % NN cord-021894-lq8yr710 128 35 ) ) -RRB- cord-021894-lq8yr710 128 36 and and CC cord-021894-lq8yr710 128 37 very very RB cord-021894-lq8yr710 128 38 severe severe JJ cord-021894-lq8yr710 128 39 RSV RSV NNP cord-021894-lq8yr710 128 40 disease disease NN cord-021894-lq8yr710 128 41 ( ( -LRB- cord-021894-lq8yr710 128 42 SpO SpO NNP cord-021894-lq8yr710 128 43 2 2 CD cord-021894-lq8yr710 128 44 < < XX cord-021894-lq8yr710 128 45 90 90 CD cord-021894-lq8yr710 128 46 % % NN cord-021894-lq8yr710 128 47 , , , cord-021894-lq8yr710 128 48 inability inability NN cord-021894-lq8yr710 128 49 to to TO cord-021894-lq8yr710 128 50 feed feed VB cord-021894-lq8yr710 128 51 orally orally RB cord-021894-lq8yr710 128 52 , , , cord-021894-lq8yr710 128 53 or or CC cord-021894-lq8yr710 128 54 reduced reduce VBN cord-021894-lq8yr710 128 55 level level NN cord-021894-lq8yr710 128 56 of of IN cord-021894-lq8yr710 128 57 consciousness consciousness NN cord-021894-lq8yr710 128 58 ) ) -RRB- cord-021894-lq8yr710 128 59 . . . cord-021894-lq8yr710 129 1 66 66 CD cord-021894-lq8yr710 129 2 Infants infant NNS cord-021894-lq8yr710 129 3 can can MD cord-021894-lq8yr710 129 4 display display VB cord-021894-lq8yr710 129 5 variance variance NN cord-021894-lq8yr710 129 6 in in IN cord-021894-lq8yr710 129 7 SpO spo JJ cord-021894-lq8yr710 129 8 2 2 CD cord-021894-lq8yr710 129 9 within within IN cord-021894-lq8yr710 129 10 this this DT cord-021894-lq8yr710 129 11 range range NN cord-021894-lq8yr710 129 12 ( ( -LRB- cord-021894-lq8yr710 129 13 90 90 CD cord-021894-lq8yr710 129 14 % % NN cord-021894-lq8yr710 129 15 to to TO cord-021894-lq8yr710 129 16 95 95 CD cord-021894-lq8yr710 129 17 % % NN cord-021894-lq8yr710 129 18 ) ) -RRB- cord-021894-lq8yr710 129 19 over over IN cord-021894-lq8yr710 129 20 short short JJ cord-021894-lq8yr710 129 21 periods period NNS cord-021894-lq8yr710 129 22 of of IN cord-021894-lq8yr710 129 23 observation observation NN cord-021894-lq8yr710 129 24 without without IN cord-021894-lq8yr710 129 25 significant significant JJ cord-021894-lq8yr710 129 26 change change NN cord-021894-lq8yr710 129 27 in in IN cord-021894-lq8yr710 129 28 clinical clinical JJ cord-021894-lq8yr710 129 29 status status NN cord-021894-lq8yr710 129 30 , , , cord-021894-lq8yr710 129 31 58,62,67 58,62,67 CD cord-021894-lq8yr710 129 32 which which WDT cord-021894-lq8yr710 129 33 may may MD cord-021894-lq8yr710 129 34 limit limit VB cord-021894-lq8yr710 129 35 the the DT cord-021894-lq8yr710 129 36 discriminatory discriminatory JJ cord-021894-lq8yr710 129 37 reliability reliability NN cord-021894-lq8yr710 129 38 of of IN cord-021894-lq8yr710 129 39 these these DT cord-021894-lq8yr710 129 40 definitions definition NNS cord-021894-lq8yr710 129 41 . . . cord-021894-lq8yr710 130 1 From from IN cord-021894-lq8yr710 130 2 a a DT cord-021894-lq8yr710 130 3 secondary secondary JJ cord-021894-lq8yr710 130 4 care care NN cord-021894-lq8yr710 130 5 perspective perspective NN cord-021894-lq8yr710 130 6 , , , cord-021894-lq8yr710 130 7 moderate moderate JJ cord-021894-lq8yr710 130 8 severity severity NN cord-021894-lq8yr710 130 9 is be VBZ cord-021894-lq8yr710 130 10 often often RB cord-021894-lq8yr710 130 11 considered consider VBN cord-021894-lq8yr710 130 12 a a DT cord-021894-lq8yr710 130 13 need need NN cord-021894-lq8yr710 130 14 for for IN cord-021894-lq8yr710 130 15 admission admission NN cord-021894-lq8yr710 130 16 to to IN cord-021894-lq8yr710 130 17 hospital hospital NN cord-021894-lq8yr710 130 18 and and CC cord-021894-lq8yr710 130 19 severe severe JJ cord-021894-lq8yr710 130 20 by by IN cord-021894-lq8yr710 130 21 need need NN cord-021894-lq8yr710 130 22 for for IN cord-021894-lq8yr710 130 23 critical critical JJ cord-021894-lq8yr710 130 24 care care NN cord-021894-lq8yr710 130 25 ( ( -LRB- cord-021894-lq8yr710 130 26 positive positive JJ cord-021894-lq8yr710 130 27 pressure pressure NN cord-021894-lq8yr710 130 28 support support NN cord-021894-lq8yr710 130 29 ) ) -RRB- cord-021894-lq8yr710 130 30 . . . cord-021894-lq8yr710 131 1 Clinical clinical JJ cord-021894-lq8yr710 131 2 scores score NNS cord-021894-lq8yr710 131 3 are be VBP cord-021894-lq8yr710 131 4 often often RB cord-021894-lq8yr710 131 5 designed design VBN cord-021894-lq8yr710 131 6 to to TO cord-021894-lq8yr710 131 7 identify identify VB cord-021894-lq8yr710 131 8 transition transition NN cord-021894-lq8yr710 131 9 points point NNS cord-021894-lq8yr710 131 10 in in IN cord-021894-lq8yr710 131 11 the the DT cord-021894-lq8yr710 131 12 level level NN cord-021894-lq8yr710 131 13 of of IN cord-021894-lq8yr710 131 14 care care NN cord-021894-lq8yr710 131 15 required require VBN cord-021894-lq8yr710 131 16 . . . cord-021894-lq8yr710 132 1 64 64 CD cord-021894-lq8yr710 133 1 The the DT cord-021894-lq8yr710 133 2 currently currently RB cord-021894-lq8yr710 133 3 available available JJ cord-021894-lq8yr710 133 4 evidence evidence NN cord-021894-lq8yr710 133 5 concerning concern VBG cord-021894-lq8yr710 133 6 transition transition NN cord-021894-lq8yr710 133 7 points point NNS cord-021894-lq8yr710 133 8 in in IN cord-021894-lq8yr710 133 9 level level NN cord-021894-lq8yr710 133 10 of of IN cord-021894-lq8yr710 133 11 care care NN cord-021894-lq8yr710 133 12 is be VBZ cord-021894-lq8yr710 133 13 poor poor JJ cord-021894-lq8yr710 133 14 . . . cord-021894-lq8yr710 134 1 Treatment treatment NN cord-021894-lq8yr710 134 2 guidance guidance NN cord-021894-lq8yr710 134 3 , , , cord-021894-lq8yr710 134 4 particularly particularly RB cord-021894-lq8yr710 134 5 benefit benefit VBP cord-021894-lq8yr710 134 6 from from IN cord-021894-lq8yr710 134 7 use use NN cord-021894-lq8yr710 134 8 of of IN cord-021894-lq8yr710 134 9 interventions intervention NNS cord-021894-lq8yr710 134 10 at at IN cord-021894-lq8yr710 134 11 the the DT cord-021894-lq8yr710 134 12 ED ED NNP cord-021894-lq8yr710 134 13 / / SYM cord-021894-lq8yr710 134 14 Ward Ward NNP cord-021894-lq8yr710 134 15 ( ( -LRB- cord-021894-lq8yr710 134 16 i.e. i.e. FW cord-021894-lq8yr710 134 17 , , , cord-021894-lq8yr710 134 18 SpO SpO NNP cord-021894-lq8yr710 134 19 2 2 CD cord-021894-lq8yr710 134 20 ) ) -RRB- cord-021894-lq8yr710 134 21 68 68 CD cord-021894-lq8yr710 134 22 and and CC cord-021894-lq8yr710 134 23 ward ward NN cord-021894-lq8yr710 134 24 / / SYM cord-021894-lq8yr710 134 25 critical critical JJ cord-021894-lq8yr710 134 26 care care NN cord-021894-lq8yr710 134 27 floor floor NN cord-021894-lq8yr710 134 28 interface interface NN cord-021894-lq8yr710 134 29 ( ( -LRB- cord-021894-lq8yr710 135 1 i.e. i.e. FW cord-021894-lq8yr710 135 2 , , , cord-021894-lq8yr710 135 3 highflow highflow NNP cord-021894-lq8yr710 135 4 nasal nasal NN cord-021894-lq8yr710 135 5 cannula cannula NN cord-021894-lq8yr710 135 6 [ [ -LRB- cord-021894-lq8yr710 135 7 HFNC HFNC NNP cord-021894-lq8yr710 135 8 ] ] -RRB- cord-021894-lq8yr710 135 9 oxygen oxygen NN cord-021894-lq8yr710 135 10 and and CC cord-021894-lq8yr710 135 11 continuous continuous JJ cord-021894-lq8yr710 135 12 positive positive JJ cord-021894-lq8yr710 135 13 airway airway NN cord-021894-lq8yr710 135 14 pressure pressure NN cord-021894-lq8yr710 135 15 [ [ -LRB- cord-021894-lq8yr710 135 16 CPAP CPAP NNP cord-021894-lq8yr710 135 17 ] ] -RRB- cord-021894-lq8yr710 135 18 ) ) -RRB- cord-021894-lq8yr710 135 19 is be VBZ cord-021894-lq8yr710 135 20 much much RB cord-021894-lq8yr710 135 21 needed need VBN cord-021894-lq8yr710 135 22 . . . cord-021894-lq8yr710 136 1 Guidelines guideline NNS cord-021894-lq8yr710 136 2 have have VBP cord-021894-lq8yr710 136 3 provided provide VBN cord-021894-lq8yr710 136 4 signs sign NNS cord-021894-lq8yr710 136 5 and and CC cord-021894-lq8yr710 136 6 symptoms symptom NNS cord-021894-lq8yr710 136 7 that that WDT cord-021894-lq8yr710 136 8 should should MD cord-021894-lq8yr710 136 9 alert alert VB cord-021894-lq8yr710 136 10 clinicians clinician NNS cord-021894-lq8yr710 136 11 to to IN cord-021894-lq8yr710 136 12 a a DT cord-021894-lq8yr710 136 13 child child NN cord-021894-lq8yr710 136 14 at at IN cord-021894-lq8yr710 136 15 risk risk NN cord-021894-lq8yr710 136 16 of of IN cord-021894-lq8yr710 136 17 deterioration deterioration NN cord-021894-lq8yr710 136 18 and and CC cord-021894-lq8yr710 136 19 suggested suggest VBD cord-021894-lq8yr710 136 20 criteria criterion NNS cord-021894-lq8yr710 136 21 for for IN cord-021894-lq8yr710 136 22 admission admission NN cord-021894-lq8yr710 136 23 to to IN cord-021894-lq8yr710 136 24 the the DT cord-021894-lq8yr710 136 25 hospital hospital NN cord-021894-lq8yr710 136 26 . . . cord-021894-lq8yr710 137 1 26 26 CD cord-021894-lq8yr710 138 1 In in IN cord-021894-lq8yr710 138 2 hospitals hospital NNS cord-021894-lq8yr710 138 3 , , , cord-021894-lq8yr710 138 4 those those DT cord-021894-lq8yr710 138 5 most most RBS cord-021894-lq8yr710 138 6 likely likely JJ cord-021894-lq8yr710 138 7 to to TO cord-021894-lq8yr710 138 8 deteriorate deteriorate VB cord-021894-lq8yr710 138 9 to to IN cord-021894-lq8yr710 138 10 the the DT cord-021894-lq8yr710 138 11 extent extent NN cord-021894-lq8yr710 138 12 of of IN cord-021894-lq8yr710 138 13 being be VBG cord-021894-lq8yr710 138 14 provided provide VBN cord-021894-lq8yr710 138 15 with with IN cord-021894-lq8yr710 138 16 critical critical JJ cord-021894-lq8yr710 138 17 care care NN cord-021894-lq8yr710 138 18 support support NN cord-021894-lq8yr710 138 19 are be VBP cord-021894-lq8yr710 138 20 of of IN cord-021894-lq8yr710 138 21 lower low JJR cord-021894-lq8yr710 138 22 birth birth NN cord-021894-lq8yr710 138 23 weight weight NN cord-021894-lq8yr710 138 24 ( ( -LRB- cord-021894-lq8yr710 138 25 < < XX cord-021894-lq8yr710 138 26 5 5 CD cord-021894-lq8yr710 138 27 lbs lb NNS cord-021894-lq8yr710 138 28 , , , cord-021894-lq8yr710 138 29 2.25 2.25 CD cord-021894-lq8yr710 138 30 kg kg NNS cord-021894-lq8yr710 138 31 ) ) -RRB- cord-021894-lq8yr710 138 32 and/or and/or CC cord-021894-lq8yr710 138 33 have have VB cord-021894-lq8yr710 138 34 a a DT cord-021894-lq8yr710 138 35 respiratory respiratory JJ cord-021894-lq8yr710 138 36 rate rate NN cord-021894-lq8yr710 138 37 ≥70 ≥70 NNP cord-021894-lq8yr710 138 38 / / SYM cord-021894-lq8yr710 138 39 min min NN cord-021894-lq8yr710 138 40 on on IN cord-021894-lq8yr710 138 41 day day NN cord-021894-lq8yr710 138 42 1 1 CD cord-021894-lq8yr710 138 43 of of IN cord-021894-lq8yr710 138 44 admission admission NN cord-021894-lq8yr710 138 45 . . . cord-021894-lq8yr710 139 1 57 57 CD cord-021894-lq8yr710 139 2 Chest chest NN cord-021894-lq8yr710 139 3 radiography radiography NN cord-021894-lq8yr710 139 4 is be VBZ cord-021894-lq8yr710 139 5 not not RB cord-021894-lq8yr710 139 6 required require VBN cord-021894-lq8yr710 139 7 to to TO cord-021894-lq8yr710 139 8 confirm confirm VB cord-021894-lq8yr710 139 9 a a DT cord-021894-lq8yr710 139 10 diagnosis diagnosis NN cord-021894-lq8yr710 139 11 of of IN cord-021894-lq8yr710 139 12 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 139 13 . . . cord-021894-lq8yr710 140 1 A a DT cord-021894-lq8yr710 140 2 chest chest NN cord-021894-lq8yr710 140 3 radiograph radiograph NN cord-021894-lq8yr710 140 4 often often RB cord-021894-lq8yr710 140 5 leads lead VBZ cord-021894-lq8yr710 140 6 to to IN cord-021894-lq8yr710 140 7 increased increase VBN cord-021894-lq8yr710 140 8 diagnostic diagnostic JJ cord-021894-lq8yr710 140 9 uncertainty uncertainty NN cord-021894-lq8yr710 140 10 as as IN cord-021894-lq8yr710 140 11 the the DT cord-021894-lq8yr710 140 12 features feature NNS cord-021894-lq8yr710 140 13 may may MD cord-021894-lq8yr710 140 14 be be VB cord-021894-lq8yr710 140 15 similar similar JJ cord-021894-lq8yr710 140 16 to to IN cord-021894-lq8yr710 140 17 those those DT cord-021894-lq8yr710 140 18 of of IN cord-021894-lq8yr710 140 19 pneumonia pneumonia NN cord-021894-lq8yr710 140 20 ( ( -LRB- cord-021894-lq8yr710 140 21 atelectasis atelectasis NN cord-021894-lq8yr710 140 22 , , , cord-021894-lq8yr710 140 23 mucous mucous JJ cord-021894-lq8yr710 140 24 plugging plugging NN cord-021894-lq8yr710 140 25 , , , cord-021894-lq8yr710 140 26 and and CC cord-021894-lq8yr710 140 27 loss loss NN cord-021894-lq8yr710 140 28 of of IN cord-021894-lq8yr710 140 29 volume volume NN cord-021894-lq8yr710 140 30 ) ) -RRB- cord-021894-lq8yr710 140 31 and and CC cord-021894-lq8yr710 140 32 consequently consequently RB cord-021894-lq8yr710 140 33 lead lead VBP cord-021894-lq8yr710 140 34 to to IN cord-021894-lq8yr710 140 35 greater great JJR cord-021894-lq8yr710 140 36 inappropriate inappropriate JJ cord-021894-lq8yr710 140 37 use use NN cord-021894-lq8yr710 140 38 of of IN cord-021894-lq8yr710 140 39 antibiotics antibiotic NNS cord-021894-lq8yr710 140 40 . . . cord-021894-lq8yr710 141 1 69 69 CD cord-021894-lq8yr710 141 2 Chest chest NN cord-021894-lq8yr710 141 3 radiography radiography NN cord-021894-lq8yr710 141 4 should should MD cord-021894-lq8yr710 141 5 be be VB cord-021894-lq8yr710 141 6 reserved reserve VBN cord-021894-lq8yr710 141 7 for for IN cord-021894-lq8yr710 141 8 a a DT cord-021894-lq8yr710 141 9 child child NN cord-021894-lq8yr710 141 10 who who WP cord-021894-lq8yr710 141 11 is be VBZ cord-021894-lq8yr710 141 12 atypical atypical JJ cord-021894-lq8yr710 141 13 , , , cord-021894-lq8yr710 141 14 for for IN cord-021894-lq8yr710 141 15 example example NN cord-021894-lq8yr710 141 16 , , , cord-021894-lq8yr710 141 17 showing show VBG cord-021894-lq8yr710 141 18 persistently persistently RB cord-021894-lq8yr710 141 19 focal focal JJ cord-021894-lq8yr710 141 20 crackles crackle NNS cord-021894-lq8yr710 141 21 , , , cord-021894-lq8yr710 141 22 a a DT cord-021894-lq8yr710 141 23 temperature temperature NN cord-021894-lq8yr710 141 24 remaining remain VBG cord-021894-lq8yr710 141 25 above above IN cord-021894-lq8yr710 141 26 39 39 CD cord-021894-lq8yr710 141 27 ° ° NN cord-021894-lq8yr710 141 28 C c NN cord-021894-lq8yr710 141 29 despite despite IN cord-021894-lq8yr710 141 30 antipyretics antipyretic NNS cord-021894-lq8yr710 141 31 , , , cord-021894-lq8yr710 141 32 or or CC cord-021894-lq8yr710 141 33 respiratory respiratory JJ cord-021894-lq8yr710 141 34 failure failure NN cord-021894-lq8yr710 141 35 requiring require VBG cord-021894-lq8yr710 141 36 critical critical JJ cord-021894-lq8yr710 141 37 care care NN cord-021894-lq8yr710 141 38 support support NN cord-021894-lq8yr710 141 39 . . . cord-021894-lq8yr710 142 1 26 26 CD cord-021894-lq8yr710 142 2 , , , cord-021894-lq8yr710 142 3 70 70 CD cord-021894-lq8yr710 142 4 Laboratory Laboratory NNP cord-021894-lq8yr710 142 5 tests test NNS cord-021894-lq8yr710 142 6 do do VBP cord-021894-lq8yr710 142 7 not not RB cord-021894-lq8yr710 142 8 aid aid VB cord-021894-lq8yr710 142 9 in in IN cord-021894-lq8yr710 142 10 the the DT cord-021894-lq8yr710 142 11 clinical clinical JJ cord-021894-lq8yr710 142 12 diagnosis diagnosis NN cord-021894-lq8yr710 142 13 of of IN cord-021894-lq8yr710 142 14 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 142 15 . . . cord-021894-lq8yr710 143 1 Serious serious JJ cord-021894-lq8yr710 143 2 bacterial bacterial JJ cord-021894-lq8yr710 143 3 infection infection NN cord-021894-lq8yr710 143 4 is be VBZ cord-021894-lq8yr710 143 5 unusual unusual JJ cord-021894-lq8yr710 143 6 and and CC cord-021894-lq8yr710 143 7 complete complete JJ cord-021894-lq8yr710 143 8 blood blood NN cord-021894-lq8yr710 143 9 counts count NNS cord-021894-lq8yr710 143 10 and and CC cord-021894-lq8yr710 143 11 blood blood NN cord-021894-lq8yr710 143 12 cultures culture NNS cord-021894-lq8yr710 143 13 are be VBP cord-021894-lq8yr710 143 14 unhelpful unhelpful JJ cord-021894-lq8yr710 143 15 ( ( -LRB- cord-021894-lq8yr710 143 16 though though IN cord-021894-lq8yr710 143 17 recent recent JJ cord-021894-lq8yr710 143 18 evidence evidence NN cord-021894-lq8yr710 143 19 suggests suggest VBZ cord-021894-lq8yr710 143 20 that that IN cord-021894-lq8yr710 143 21 although although IN cord-021894-lq8yr710 143 22 still still RB cord-021894-lq8yr710 143 23 uncommon uncommon JJ cord-021894-lq8yr710 143 24 , , , cord-021894-lq8yr710 143 25 it -PRON- PRP cord-021894-lq8yr710 143 26 may may MD cord-021894-lq8yr710 143 27 be be VB cord-021894-lq8yr710 143 28 more more RBR cord-021894-lq8yr710 143 29 frequent frequent JJ cord-021894-lq8yr710 143 30 than than IN cord-021894-lq8yr710 143 31 previously previously RB cord-021894-lq8yr710 143 32 considered consider VBN cord-021894-lq8yr710 143 33 ) ) -RRB- cord-021894-lq8yr710 143 34 . . . cord-021894-lq8yr710 144 1 65 65 CD cord-021894-lq8yr710 145 1 Dehydration dehydration NN cord-021894-lq8yr710 145 2 is be VBZ cord-021894-lq8yr710 145 3 usually usually RB cord-021894-lq8yr710 145 4 mild mild JJ cord-021894-lq8yr710 145 5 and and CC cord-021894-lq8yr710 145 6 best well RBS cord-021894-lq8yr710 145 7 assessed assess VBN cord-021894-lq8yr710 145 8 clinically clinically RB cord-021894-lq8yr710 145 9 without without IN cord-021894-lq8yr710 145 10 electrolyte electrolyte JJ cord-021894-lq8yr710 145 11 measurement measurement NN cord-021894-lq8yr710 145 12 . . . cord-021894-lq8yr710 146 1 Approximately approximately RB cord-021894-lq8yr710 146 2 6 6 CD cord-021894-lq8yr710 146 3 % % NN cord-021894-lq8yr710 146 4 of of IN cord-021894-lq8yr710 146 5 infants infant NNS cord-021894-lq8yr710 146 6 with with IN cord-021894-lq8yr710 146 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 146 8 can can MD cord-021894-lq8yr710 146 9 have have VB cord-021894-lq8yr710 146 10 concurrent concurrent JJ cord-021894-lq8yr710 146 11 urinary urinary JJ cord-021894-lq8yr710 146 12 tract tract NN cord-021894-lq8yr710 146 13 infection infection NN cord-021894-lq8yr710 146 14 , , , cord-021894-lq8yr710 146 15 so so CC cord-021894-lq8yr710 146 16 urine urine NN cord-021894-lq8yr710 146 17 culture culture NN cord-021894-lq8yr710 146 18 may may MD cord-021894-lq8yr710 146 19 be be VB cord-021894-lq8yr710 146 20 of of IN cord-021894-lq8yr710 146 21 value value NN cord-021894-lq8yr710 146 22 in in IN cord-021894-lq8yr710 146 23 persistently persistently RB cord-021894-lq8yr710 146 24 febrile febrile JJ cord-021894-lq8yr710 146 25 infants infant NNS cord-021894-lq8yr710 146 26 , , , cord-021894-lq8yr710 146 27 particularly particularly RB cord-021894-lq8yr710 146 28 those those DT cord-021894-lq8yr710 146 29 under under IN cord-021894-lq8yr710 146 30 3 3 CD cord-021894-lq8yr710 146 31 months month NNS cord-021894-lq8yr710 146 32 of of IN cord-021894-lq8yr710 146 33 age age NN cord-021894-lq8yr710 146 34 . . . cord-021894-lq8yr710 147 1 71 71 CD cord-021894-lq8yr710 147 2 Measurement Measurement NNP cord-021894-lq8yr710 147 3 of of IN cord-021894-lq8yr710 147 4 arterial arterial JJ cord-021894-lq8yr710 147 5 / / SYM cord-021894-lq8yr710 147 6 capillary capillary JJ cord-021894-lq8yr710 147 7 carbon carbon NN cord-021894-lq8yr710 147 8 dioxide dioxide NN cord-021894-lq8yr710 147 9 is be VBZ cord-021894-lq8yr710 147 10 commonly commonly RB cord-021894-lq8yr710 147 11 performed perform VBN cord-021894-lq8yr710 147 12 , , , cord-021894-lq8yr710 147 13 but but CC cord-021894-lq8yr710 147 14 can can MD cord-021894-lq8yr710 147 15 be be VB cord-021894-lq8yr710 147 16 restricted restrict VBN cord-021894-lq8yr710 147 17 to to IN cord-021894-lq8yr710 147 18 those those DT cord-021894-lq8yr710 147 19 children child NNS cord-021894-lq8yr710 147 20 with with IN cord-021894-lq8yr710 147 21 increased increase VBN cord-021894-lq8yr710 147 22 respiratory respiratory JJ cord-021894-lq8yr710 147 23 rate rate NN cord-021894-lq8yr710 147 24 and and CC cord-021894-lq8yr710 147 25 work work NN cord-021894-lq8yr710 147 26 of of IN cord-021894-lq8yr710 147 27 breathing breathe VBG cord-021894-lq8yr710 147 28 despite despite IN cord-021894-lq8yr710 147 29 oxygen oxygen NN cord-021894-lq8yr710 147 30 supplementation supplementation NN cord-021894-lq8yr710 147 31 . . . cord-021894-lq8yr710 148 1 72 72 CD cord-021894-lq8yr710 149 1 The the DT cord-021894-lq8yr710 149 2 clinical clinical JJ cord-021894-lq8yr710 149 3 interpretation interpretation NN cord-021894-lq8yr710 149 4 of of IN cord-021894-lq8yr710 149 5 signs sign NNS cord-021894-lq8yr710 149 6 and and CC cord-021894-lq8yr710 149 7 symptoms symptom NNS cord-021894-lq8yr710 149 8 is be VBZ cord-021894-lq8yr710 149 9 difficult difficult JJ cord-021894-lq8yr710 149 10 in in IN cord-021894-lq8yr710 149 11 a a DT cord-021894-lq8yr710 149 12 condition condition NN cord-021894-lq8yr710 149 13 where where WRB cord-021894-lq8yr710 149 14 age age NN cord-021894-lq8yr710 149 15 boundaries boundary NNS cord-021894-lq8yr710 149 16 are be VBP cord-021894-lq8yr710 149 17 loose loose JJ cord-021894-lq8yr710 149 18 ( ( -LRB- cord-021894-lq8yr710 149 19 and and CC cord-021894-lq8yr710 149 20 skew skew VB cord-021894-lq8yr710 149 21 to to IN cord-021894-lq8yr710 149 22 older old JJR cord-021894-lq8yr710 149 23 ages age NNS cord-021894-lq8yr710 149 24 in in IN cord-021894-lq8yr710 149 25 those those DT cord-021894-lq8yr710 149 26 with with IN cord-021894-lq8yr710 149 27 comorbidity comorbidity NN cord-021894-lq8yr710 149 28 ) ) -RRB- cord-021894-lq8yr710 149 29 and and CC cord-021894-lq8yr710 149 30 symptoms symptom NNS cord-021894-lq8yr710 149 31 vary vary VBP cord-021894-lq8yr710 149 32 from from IN cord-021894-lq8yr710 149 33 patient patient NN cord-021894-lq8yr710 149 34 to to IN cord-021894-lq8yr710 149 35 patient patient NN cord-021894-lq8yr710 149 36 and and CC cord-021894-lq8yr710 149 37 time time NN cord-021894-lq8yr710 149 38 to to IN cord-021894-lq8yr710 149 39 time time NN cord-021894-lq8yr710 149 40 . . . cord-021894-lq8yr710 150 1 This this DT cord-021894-lq8yr710 150 2 naturally naturally RB cord-021894-lq8yr710 150 3 leads lead VBZ cord-021894-lq8yr710 150 4 to to IN cord-021894-lq8yr710 150 5 variation variation NN cord-021894-lq8yr710 150 6 in in IN cord-021894-lq8yr710 150 7 diagnosis diagnosis NN cord-021894-lq8yr710 150 8 and and CC cord-021894-lq8yr710 150 9 differential differential JJ cord-021894-lq8yr710 150 10 diagnosis diagnosis NN cord-021894-lq8yr710 150 11 . . . cord-021894-lq8yr710 151 1 There there EX cord-021894-lq8yr710 151 2 is be VBZ cord-021894-lq8yr710 151 3 a a DT cord-021894-lq8yr710 151 4 common common JJ cord-021894-lq8yr710 151 5 understanding understanding NN cord-021894-lq8yr710 151 6 that that WDT cord-021894-lq8yr710 151 7 a a DT cord-021894-lq8yr710 151 8 clearer clear JJR cord-021894-lq8yr710 151 9 diagnosis diagnosis NN cord-021894-lq8yr710 151 10 is be VBZ cord-021894-lq8yr710 151 11 possible possible JJ cord-021894-lq8yr710 151 12 in in IN cord-021894-lq8yr710 151 13 those those DT cord-021894-lq8yr710 151 14 under under IN cord-021894-lq8yr710 151 15 1 1 CD cord-021894-lq8yr710 151 16 year year NN cord-021894-lq8yr710 151 17 of of IN cord-021894-lq8yr710 151 18 age age NN cord-021894-lq8yr710 151 19 and and CC cord-021894-lq8yr710 151 20 most most JJS cord-021894-lq8yr710 151 21 guidelines guideline NNS cord-021894-lq8yr710 151 22 reflect reflect VBP cord-021894-lq8yr710 151 23 this this DT cord-021894-lq8yr710 151 24 . . . cord-021894-lq8yr710 152 1 However however RB cord-021894-lq8yr710 152 2 , , , cord-021894-lq8yr710 152 3 constraining constrain VBG cord-021894-lq8yr710 152 4 a a DT cord-021894-lq8yr710 152 5 diagnosis diagnosis NN cord-021894-lq8yr710 152 6 of of IN cord-021894-lq8yr710 152 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 152 8 to to IN cord-021894-lq8yr710 152 9 those those DT cord-021894-lq8yr710 152 10 less less JJR cord-021894-lq8yr710 152 11 than than IN cord-021894-lq8yr710 152 12 1 1 CD cord-021894-lq8yr710 152 13 year year NN cord-021894-lq8yr710 152 14 of of IN cord-021894-lq8yr710 152 15 age age NN cord-021894-lq8yr710 152 16 may may MD cord-021894-lq8yr710 152 17 reduce reduce VB cord-021894-lq8yr710 152 18 the the DT cord-021894-lq8yr710 152 19 ability ability NN cord-021894-lq8yr710 152 20 to to TO cord-021894-lq8yr710 152 21 identify identify VB cord-021894-lq8yr710 152 22 the the DT cord-021894-lq8yr710 152 23 whole whole JJ cord-021894-lq8yr710 152 24 population population NN cord-021894-lq8yr710 152 25 of of IN cord-021894-lq8yr710 152 26 children child NNS cord-021894-lq8yr710 152 27 with with IN cord-021894-lq8yr710 152 28 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 152 29 who who WP cord-021894-lq8yr710 152 30 could could MD cord-021894-lq8yr710 152 31 benefit benefit VB cord-021894-lq8yr710 152 32 from from IN cord-021894-lq8yr710 152 33 potential potential JJ cord-021894-lq8yr710 152 34 interventions intervention NNS cord-021894-lq8yr710 152 35 . . . cord-021894-lq8yr710 153 1 In in IN cord-021894-lq8yr710 153 2 general general JJ cord-021894-lq8yr710 153 3 , , , cord-021894-lq8yr710 153 4 a a DT cord-021894-lq8yr710 153 5 broader broad JJR cord-021894-lq8yr710 153 6 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 153 7 ) ) -RRB- cord-021894-lq8yr710 153 8 is be VBZ cord-021894-lq8yr710 153 9 often often RB cord-021894-lq8yr710 153 10 performed perform VBN cord-021894-lq8yr710 153 11 to to TO cord-021894-lq8yr710 153 12 aid aid VB cord-021894-lq8yr710 153 13 cohorting cohorting NN cord-021894-lq8yr710 153 14 of of IN cord-021894-lq8yr710 153 15 patients patient NNS cord-021894-lq8yr710 153 16 within within IN cord-021894-lq8yr710 153 17 hospitals hospital NNS cord-021894-lq8yr710 153 18 . . . cord-021894-lq8yr710 154 1 The the DT cord-021894-lq8yr710 154 2 increasing increase VBG cord-021894-lq8yr710 154 3 recognition recognition NN cord-021894-lq8yr710 154 4 that that IN cord-021894-lq8yr710 154 5 multiple multiple JJ cord-021894-lq8yr710 154 6 viruses virus NNS cord-021894-lq8yr710 154 7 may may MD cord-021894-lq8yr710 154 8 be be VB cord-021894-lq8yr710 154 9 identified identify VBN cord-021894-lq8yr710 154 10 in in IN cord-021894-lq8yr710 154 11 those those DT cord-021894-lq8yr710 154 12 with with IN cord-021894-lq8yr710 154 13 acute acute JJ cord-021894-lq8yr710 154 14 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 154 15 has have VBZ cord-021894-lq8yr710 154 16 called call VBN cord-021894-lq8yr710 154 17 into into IN cord-021894-lq8yr710 154 18 question question NN cord-021894-lq8yr710 154 19 the the DT cord-021894-lq8yr710 154 20 benefit benefit NN cord-021894-lq8yr710 154 21 of of IN cord-021894-lq8yr710 154 22 cohorting cohorte VBG cord-021894-lq8yr710 154 23 based base VBN cord-021894-lq8yr710 154 24 on on IN cord-021894-lq8yr710 154 25 RSV RSV NNP cord-021894-lq8yr710 154 26 status status NN cord-021894-lq8yr710 154 27 . . . cord-021894-lq8yr710 155 1 78 78 CD cord-021894-lq8yr710 155 2 PCR PCR NNP cord-021894-lq8yr710 155 3 diagnostics diagnostic NNS cord-021894-lq8yr710 155 4 may may MD cord-021894-lq8yr710 155 5 sometimes sometimes RB cord-021894-lq8yr710 155 6 be be VB cord-021894-lq8yr710 155 7 considered consider VBN cord-021894-lq8yr710 155 8 oversensitive oversensitive JJ cord-021894-lq8yr710 155 9 to to IN cord-021894-lq8yr710 155 10 the the DT cord-021894-lq8yr710 155 11 detection detection NN cord-021894-lq8yr710 155 12 of of IN cord-021894-lq8yr710 155 13 virus virus NN cord-021894-lq8yr710 155 14 fragments fragment NNS cord-021894-lq8yr710 155 15 postinfection postinfection NN cord-021894-lq8yr710 155 16 , , , cord-021894-lq8yr710 155 17 and and CC cord-021894-lq8yr710 155 18 multiplex multiplex JJ cord-021894-lq8yr710 155 19 PCR PCR NNP cord-021894-lq8yr710 155 20 results result NNS cord-021894-lq8yr710 155 21 should should MD cord-021894-lq8yr710 155 22 be be VB cord-021894-lq8yr710 155 23 interpreted interpret VBN cord-021894-lq8yr710 155 24 with with IN cord-021894-lq8yr710 155 25 this this DT cord-021894-lq8yr710 155 26 understanding understanding NN cord-021894-lq8yr710 155 27 . . . cord-021894-lq8yr710 156 1 Differential differential JJ cord-021894-lq8yr710 156 2 diagnosis diagnosis NN cord-021894-lq8yr710 156 3 includes include VBZ cord-021894-lq8yr710 156 4 bacterial bacterial JJ cord-021894-lq8yr710 156 5 pneumonia pneumonia NN cord-021894-lq8yr710 156 6 or or CC cord-021894-lq8yr710 156 7 an an DT cord-021894-lq8yr710 156 8 alternative alternative JJ cord-021894-lq8yr710 156 9 cause cause NN cord-021894-lq8yr710 156 10 of of IN cord-021894-lq8yr710 156 11 crackles crackle NNS cord-021894-lq8yr710 156 12 , , , cord-021894-lq8yr710 156 13 wheeze wheeze NN cord-021894-lq8yr710 156 14 , , , cord-021894-lq8yr710 156 15 and and CC cord-021894-lq8yr710 156 16 increased increase VBN cord-021894-lq8yr710 156 17 work work NN cord-021894-lq8yr710 156 18 of of IN cord-021894-lq8yr710 156 19 breathing breathing NN cord-021894-lq8yr710 156 20 in in IN cord-021894-lq8yr710 156 21 a a DT cord-021894-lq8yr710 156 22 young young JJ cord-021894-lq8yr710 156 23 child child NN cord-021894-lq8yr710 156 24 . . . cord-021894-lq8yr710 157 1 Persisting persist VBG cord-021894-lq8yr710 157 2 crackles crackle NNS cord-021894-lq8yr710 157 3 ( ( -LRB- cord-021894-lq8yr710 157 4 crepitations crepitation NNS cord-021894-lq8yr710 157 5 ) ) -RRB- cord-021894-lq8yr710 157 6 in in IN cord-021894-lq8yr710 157 7 one one CD cord-021894-lq8yr710 157 8 lung lung NN cord-021894-lq8yr710 157 9 zone zone NN cord-021894-lq8yr710 157 10 , , , cord-021894-lq8yr710 157 11 fixed fix VBN cord-021894-lq8yr710 157 12 focal focal JJ cord-021894-lq8yr710 157 13 wheeze wheeze NN cord-021894-lq8yr710 157 14 , , , cord-021894-lq8yr710 157 15 persistent persistent JJ cord-021894-lq8yr710 157 16 pyrexia pyrexia NN cord-021894-lq8yr710 157 17 ( ( -LRB- cord-021894-lq8yr710 157 18 > > NFP cord-021894-lq8yr710 157 19 39 39 CD cord-021894-lq8yr710 157 20 ° ° NN cord-021894-lq8yr710 157 21 C c NN cord-021894-lq8yr710 157 22 ) ) -RRB- cord-021894-lq8yr710 157 23 or or CC cord-021894-lq8yr710 157 24 persistently persistently RB cord-021894-lq8yr710 157 25 increased increase VBN cord-021894-lq8yr710 157 26 work work NN cord-021894-lq8yr710 157 27 of of IN cord-021894-lq8yr710 157 28 breathing breathing NN cord-021894-lq8yr710 157 29 in in IN cord-021894-lq8yr710 157 30 a a DT cord-021894-lq8yr710 157 31 child child NN cord-021894-lq8yr710 157 32 who who WP cord-021894-lq8yr710 157 33 appears appear VBZ cord-021894-lq8yr710 157 34 otherwise otherwise RB cord-021894-lq8yr710 157 35 recovered recover VBN cord-021894-lq8yr710 157 36 warrant warrant JJ cord-021894-lq8yr710 157 37 further further JJ cord-021894-lq8yr710 157 38 evaluation evaluation NN cord-021894-lq8yr710 157 39 . . . cord-021894-lq8yr710 158 1 Prescient prescient JJ cord-021894-lq8yr710 158 2 in in IN cord-021894-lq8yr710 158 3 the the DT cord-021894-lq8yr710 158 4 mind mind NN cord-021894-lq8yr710 158 5 of of IN cord-021894-lq8yr710 158 6 most most JJS cord-021894-lq8yr710 158 7 clinicians clinician NNS cord-021894-lq8yr710 158 8 is be VBZ cord-021894-lq8yr710 158 9 that that IN cord-021894-lq8yr710 158 10 a a DT cord-021894-lq8yr710 158 11 bacterial bacterial JJ cord-021894-lq8yr710 158 12 pneumonia pneumonia NN cord-021894-lq8yr710 158 13 may may MD cord-021894-lq8yr710 158 14 be be VB cord-021894-lq8yr710 158 15 missed miss VBN cord-021894-lq8yr710 158 16 . . . cord-021894-lq8yr710 159 1 Chest chest NN cord-021894-lq8yr710 159 2 radiographs radiograph NNS cord-021894-lq8yr710 159 3 have have VBP cord-021894-lq8yr710 159 4 similar similar JJ cord-021894-lq8yr710 159 5 appearances appearance NNS cord-021894-lq8yr710 159 6 and and CC cord-021894-lq8yr710 159 7 are be VBP cord-021894-lq8yr710 159 8 poor poor JJ cord-021894-lq8yr710 159 9 discriminators discriminator NNS cord-021894-lq8yr710 159 10 . . . cord-021894-lq8yr710 160 1 We -PRON- PRP cord-021894-lq8yr710 160 2 can can MD cord-021894-lq8yr710 160 3 assume assume VB cord-021894-lq8yr710 160 4 that that IN cord-021894-lq8yr710 160 5 bacterial bacterial JJ cord-021894-lq8yr710 160 6 coinfection coinfection NN cord-021894-lq8yr710 160 7 risk risk NN cord-021894-lq8yr710 160 8 is be VBZ cord-021894-lq8yr710 160 9 low low JJ cord-021894-lq8yr710 160 10 , , , cord-021894-lq8yr710 160 11 as as IN cord-021894-lq8yr710 160 12 the the DT cord-021894-lq8yr710 160 13 use use NN cord-021894-lq8yr710 160 14 of of IN cord-021894-lq8yr710 160 15 antibiotics antibiotic NNS cord-021894-lq8yr710 160 16 in in IN cord-021894-lq8yr710 160 17 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 160 18 is be VBZ cord-021894-lq8yr710 160 19 not not RB cord-021894-lq8yr710 160 20 associated associate VBN cord-021894-lq8yr710 160 21 with with IN cord-021894-lq8yr710 160 22 faster fast JJR cord-021894-lq8yr710 160 23 recovery recovery NN cord-021894-lq8yr710 160 24 . . . cord-021894-lq8yr710 161 1 79 79 CD cord-021894-lq8yr710 162 1 Further further JJ cord-021894-lq8yr710 162 2 investigation investigation NN cord-021894-lq8yr710 162 3 could could MD cord-021894-lq8yr710 162 4 be be VB cord-021894-lq8yr710 162 5 limited limit VBN cord-021894-lq8yr710 162 6 to to IN cord-021894-lq8yr710 162 7 those those DT cord-021894-lq8yr710 162 8 with with IN cord-021894-lq8yr710 162 9 the the DT cord-021894-lq8yr710 162 10 persisting persist VBG cord-021894-lq8yr710 162 11 clinical clinical JJ cord-021894-lq8yr710 162 12 features feature NNS cord-021894-lq8yr710 162 13 noted note VBN cord-021894-lq8yr710 162 14 above above RB cord-021894-lq8yr710 162 15 . . . cord-021894-lq8yr710 163 1 In in IN cord-021894-lq8yr710 163 2 children child NNS cord-021894-lq8yr710 163 3 with with IN cord-021894-lq8yr710 163 4 more more RBR cord-021894-lq8yr710 163 5 severe severe JJ cord-021894-lq8yr710 163 6 disease disease NN cord-021894-lq8yr710 163 7 , , , cord-021894-lq8yr710 163 8 there there EX cord-021894-lq8yr710 163 9 may may MD cord-021894-lq8yr710 163 10 be be VB cord-021894-lq8yr710 163 11 a a DT cord-021894-lq8yr710 163 12 role role NN cord-021894-lq8yr710 163 13 for for IN cord-021894-lq8yr710 163 14 antibiotics antibiotic NNS cord-021894-lq8yr710 163 15 as as IN cord-021894-lq8yr710 163 16 bacteria bacteria NNS cord-021894-lq8yr710 163 17 are be VBP cord-021894-lq8yr710 163 18 isolated isolate VBN cord-021894-lq8yr710 163 19 in in IN cord-021894-lq8yr710 163 20 33 33 CD cord-021894-lq8yr710 163 21 % % NN cord-021894-lq8yr710 163 22 to to IN cord-021894-lq8yr710 163 23 44 44 CD cord-021894-lq8yr710 163 24 % % NN cord-021894-lq8yr710 163 25 of of IN cord-021894-lq8yr710 163 26 lavage lavage NN cord-021894-lq8yr710 163 27 samples sample NNS cord-021894-lq8yr710 163 28 in in IN cord-021894-lq8yr710 163 29 children child NNS cord-021894-lq8yr710 163 30 with with IN cord-021894-lq8yr710 163 31 severe severe JJ cord-021894-lq8yr710 163 32 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 163 33 who who WP cord-021894-lq8yr710 163 34 are be VBP cord-021894-lq8yr710 163 35 intubated intubate VBN cord-021894-lq8yr710 163 36 and and CC cord-021894-lq8yr710 163 37 ventilated ventilate VBN cord-021894-lq8yr710 163 38 . . . cord-021894-lq8yr710 164 1 [ [ -LRB- cord-021894-lq8yr710 164 2 80 80 CD cord-021894-lq8yr710 164 3 ] ] -RRB- cord-021894-lq8yr710 164 4 [ [ -LRB- cord-021894-lq8yr710 164 5 81 81 CD cord-021894-lq8yr710 164 6 ] ] -RRB- cord-021894-lq8yr710 164 7 [ [ -LRB- cord-021894-lq8yr710 164 8 82 82 CD cord-021894-lq8yr710 165 1 ] ] -RRB- cord-021894-lq8yr710 165 2 definition definition NN cord-021894-lq8yr710 165 3 of of IN cord-021894-lq8yr710 165 4 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 165 5 is be VBZ cord-021894-lq8yr710 165 6 used use VBN cord-021894-lq8yr710 165 7 in in IN cord-021894-lq8yr710 165 8 North North NNP cord-021894-lq8yr710 165 9 America America NNP cord-021894-lq8yr710 165 10 and and CC cord-021894-lq8yr710 165 11 Asia Asia NNP cord-021894-lq8yr710 165 12 that that WDT cord-021894-lq8yr710 165 13 captures capture VBZ cord-021894-lq8yr710 165 14 a a DT cord-021894-lq8yr710 165 15 higher high JJR cord-021894-lq8yr710 165 16 percentage percentage NN cord-021894-lq8yr710 165 17 of of IN cord-021894-lq8yr710 165 18 older old JJR cord-021894-lq8yr710 165 19 children child NNS cord-021894-lq8yr710 165 20 with with IN cord-021894-lq8yr710 165 21 wheezing wheeze VBG cord-021894-lq8yr710 165 22 , , , cord-021894-lq8yr710 165 23 where where WRB cord-021894-lq8yr710 165 24 rhinovirus rhinovirus NN cord-021894-lq8yr710 165 25 is be VBZ cord-021894-lq8yr710 165 26 the the DT cord-021894-lq8yr710 165 27 dominant dominant JJ cord-021894-lq8yr710 165 28 infecting infect VBG cord-021894-lq8yr710 165 29 agent agent NN cord-021894-lq8yr710 165 30 . . . cord-021894-lq8yr710 166 1 73 73 CD cord-021894-lq8yr710 166 2 Such such JJ cord-021894-lq8yr710 166 3 children child NNS cord-021894-lq8yr710 166 4 may may MD cord-021894-lq8yr710 166 5 be be VB cord-021894-lq8yr710 166 6 given give VBN cord-021894-lq8yr710 166 7 a a DT cord-021894-lq8yr710 166 8 diagnosis diagnosis NN cord-021894-lq8yr710 166 9 of of IN cord-021894-lq8yr710 166 10 viral viral JJ cord-021894-lq8yr710 166 11 induced induce VBN cord-021894-lq8yr710 166 12 wheeze wheeze NN cord-021894-lq8yr710 166 13 in in IN cord-021894-lq8yr710 166 14 other other JJ cord-021894-lq8yr710 166 15 countries country NNS cord-021894-lq8yr710 166 16 . . . cord-021894-lq8yr710 167 1 There there EX cord-021894-lq8yr710 167 2 is be VBZ cord-021894-lq8yr710 167 3 most most RBS cord-021894-lq8yr710 167 4 likely likely RB cord-021894-lq8yr710 167 5 a a DT cord-021894-lq8yr710 167 6 continuum continuum NN cord-021894-lq8yr710 167 7 of of IN cord-021894-lq8yr710 167 8 viral viral JJ cord-021894-lq8yr710 167 9 lower low JJR cord-021894-lq8yr710 167 10 respiratory respiratory JJ cord-021894-lq8yr710 167 11 tract tract NN cord-021894-lq8yr710 167 12 infection infection NN cord-021894-lq8yr710 167 13 across across IN cord-021894-lq8yr710 167 14 age age NN cord-021894-lq8yr710 167 15 ranges range VBZ cord-021894-lq8yr710 167 16 that that WDT cord-021894-lq8yr710 167 17 moves move NNS cord-021894-lq8yr710 167 18 from from IN cord-021894-lq8yr710 167 19 current current JJ cord-021894-lq8yr710 167 20 diagnoses diagnosis NNS cord-021894-lq8yr710 167 21 of of IN cord-021894-lq8yr710 167 22 viral viral JJ cord-021894-lq8yr710 167 23 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 167 24 to to IN cord-021894-lq8yr710 167 25 viral viral JJ cord-021894-lq8yr710 167 26 pneumonia pneumonia NN cord-021894-lq8yr710 167 27 and and CC cord-021894-lq8yr710 167 28 viral viral RB cord-021894-lq8yr710 167 29 - - HYPH cord-021894-lq8yr710 167 30 induced induce VBN cord-021894-lq8yr710 167 31 wheeze wheeze NN cord-021894-lq8yr710 167 32 / / SYM cord-021894-lq8yr710 167 33 wheezy wheezy JJ cord-021894-lq8yr710 167 34 bronchitis bronchitis NN cord-021894-lq8yr710 167 35 . . . cord-021894-lq8yr710 168 1 74 74 CD cord-021894-lq8yr710 168 2 , , , cord-021894-lq8yr710 168 3 75 75 CD cord-021894-lq8yr710 169 1 The the DT cord-021894-lq8yr710 169 2 clinical clinical JJ cord-021894-lq8yr710 169 3 features feature VBZ cord-021894-lq8yr710 169 4 consistent consistent JJ cord-021894-lq8yr710 169 5 with with IN cord-021894-lq8yr710 169 6 a a DT cord-021894-lq8yr710 169 7 diagnosis diagnosis NN cord-021894-lq8yr710 169 8 of of IN cord-021894-lq8yr710 169 9 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 169 10 across across IN cord-021894-lq8yr710 169 11 different different JJ cord-021894-lq8yr710 169 12 guidelines guideline NNS cord-021894-lq8yr710 169 13 are be VBP cord-021894-lq8yr710 169 14 presented present VBN cord-021894-lq8yr710 169 15 in in IN cord-021894-lq8yr710 169 16 Table Table NNP cord-021894-lq8yr710 169 17 _SP cord-021894-lq8yr710 169 18 24 24 CD cord-021894-lq8yr710 169 19 .2 .2 CD cord-021894-lq8yr710 169 20 . . . cord-021894-lq8yr710 170 1 Diagnosis diagnosis NN cord-021894-lq8yr710 170 2 has have VBZ cord-021894-lq8yr710 170 3 a a DT cord-021894-lq8yr710 170 4 typical typical JJ cord-021894-lq8yr710 170 5 onset onset NN cord-021894-lq8yr710 170 6 of of IN cord-021894-lq8yr710 170 7 a a DT cord-021894-lq8yr710 170 8 viral viral JJ cord-021894-lq8yr710 170 9 respiratory respiratory JJ cord-021894-lq8yr710 170 10 tract tract NN cord-021894-lq8yr710 170 11 prodrome prodrome NN cord-021894-lq8yr710 170 12 proceeding proceed VBG cord-021894-lq8yr710 170 13 to to TO cord-021894-lq8yr710 170 14 lower lower VB cord-021894-lq8yr710 170 15 respiratory respiratory JJ cord-021894-lq8yr710 170 16 symptoms symptom NNS cord-021894-lq8yr710 170 17 over over IN cord-021894-lq8yr710 170 18 3 3 CD cord-021894-lq8yr710 170 19 to to TO cord-021894-lq8yr710 170 20 4 4 CD cord-021894-lq8yr710 170 21 days day NNS cord-021894-lq8yr710 170 22 . . . cord-021894-lq8yr710 171 1 The the DT cord-021894-lq8yr710 171 2 South south JJ cord-021894-lq8yr710 171 3 African african JJ cord-021894-lq8yr710 171 4 guideline guideline NN cord-021894-lq8yr710 171 5 ( ( -LRB- cord-021894-lq8yr710 171 6 2010 2010 CD cord-021894-lq8yr710 171 7 ) ) -RRB- cord-021894-lq8yr710 171 8 considers consider VBZ cord-021894-lq8yr710 171 9 hyperinflation hyperinflation NN cord-021894-lq8yr710 171 10 the the DT cord-021894-lq8yr710 171 11 most most RBS cord-021894-lq8yr710 171 12 reliable reliable JJ cord-021894-lq8yr710 171 13 clinical clinical JJ cord-021894-lq8yr710 171 14 sign sign NN cord-021894-lq8yr710 171 15 in in IN cord-021894-lq8yr710 171 16 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 171 17 . . . cord-021894-lq8yr710 172 1 76 76 CD cord-021894-lq8yr710 173 1 The the DT cord-021894-lq8yr710 173 2 UK UK NNP cord-021894-lq8yr710 173 3 guideline guideline NN cord-021894-lq8yr710 173 4 ( ( -LRB- cord-021894-lq8yr710 173 5 2015 2015 CD cord-021894-lq8yr710 173 6 ) ) -RRB- cord-021894-lq8yr710 173 7 provides provide VBZ cord-021894-lq8yr710 173 8 a a DT cord-021894-lq8yr710 173 9 more more RBR cord-021894-lq8yr710 173 10 proscriptive proscriptive JJ cord-021894-lq8yr710 173 11 definition definition NN cord-021894-lq8yr710 173 12 . . . cord-021894-lq8yr710 174 1 26 26 CD cord-021894-lq8yr710 174 2 Testing testing NN cord-021894-lq8yr710 174 3 of of IN cord-021894-lq8yr710 174 4 nasal nasal JJ cord-021894-lq8yr710 174 5 secretions secretion NNS cord-021894-lq8yr710 174 6 for for IN cord-021894-lq8yr710 174 7 virus virus NN cord-021894-lq8yr710 174 8 may may MD cord-021894-lq8yr710 174 9 help help VB cord-021894-lq8yr710 174 10 consolidate consolidate VB cord-021894-lq8yr710 174 11 the the DT cord-021894-lq8yr710 174 12 clinical clinical JJ cord-021894-lq8yr710 174 13 diagnosis diagnosis NN cord-021894-lq8yr710 174 14 of of IN cord-021894-lq8yr710 174 15 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 174 16 and and CC cord-021894-lq8yr710 174 17 inform inform VB cord-021894-lq8yr710 174 18 health health NN cord-021894-lq8yr710 174 19 care care NN cord-021894-lq8yr710 174 20 logistics logistic NNS cord-021894-lq8yr710 174 21 . . . cord-021894-lq8yr710 175 1 Most most RBS cord-021894-lq8yr710 175 2 commonly commonly RB cord-021894-lq8yr710 175 3 used use VBN cord-021894-lq8yr710 175 4 , , , cord-021894-lq8yr710 175 5 and and CC cord-021894-lq8yr710 175 6 with with IN cord-021894-lq8yr710 175 7 highest high JJS cord-021894-lq8yr710 175 8 precision precision NN cord-021894-lq8yr710 175 9 , , , cord-021894-lq8yr710 175 10 are be VBP cord-021894-lq8yr710 175 11 polymerase polymerase NN cord-021894-lq8yr710 175 12 chain chain NN cord-021894-lq8yr710 175 13 reaction reaction NN cord-021894-lq8yr710 175 14 ( ( -LRB- cord-021894-lq8yr710 175 15 PCR PCR NNP cord-021894-lq8yr710 175 16 ) ) -RRB- cord-021894-lq8yr710 175 17 diagnostics diagnostic NNS cord-021894-lq8yr710 175 18 for for IN cord-021894-lq8yr710 175 19 a a DT cord-021894-lq8yr710 175 20 range range NN cord-021894-lq8yr710 175 21 of of IN cord-021894-lq8yr710 175 22 respiratory respiratory JJ cord-021894-lq8yr710 175 23 viruses virus NNS cord-021894-lq8yr710 175 24 , , , cord-021894-lq8yr710 175 25 but but CC cord-021894-lq8yr710 175 26 point point NN cord-021894-lq8yr710 175 27 of of IN cord-021894-lq8yr710 175 28 care care NN cord-021894-lq8yr710 175 29 ( ( -LRB- cord-021894-lq8yr710 175 30 PoC PoC NNP cord-021894-lq8yr710 175 31 ) ) -RRB- cord-021894-lq8yr710 175 32 testing testing NN cord-021894-lq8yr710 175 33 for for IN cord-021894-lq8yr710 175 34 a a DT cord-021894-lq8yr710 175 35 more more RBR cord-021894-lq8yr710 175 36 limited limited JJ cord-021894-lq8yr710 175 37 range range NN cord-021894-lq8yr710 175 38 of of IN cord-021894-lq8yr710 175 39 viruses virus NNS cord-021894-lq8yr710 175 40 ( ( -LRB- cord-021894-lq8yr710 175 41 most most RBS cord-021894-lq8yr710 175 42 often often RB cord-021894-lq8yr710 175 43 RSV RSV NNP cord-021894-lq8yr710 175 44 ) ) -RRB- cord-021894-lq8yr710 175 45 is be VBZ cord-021894-lq8yr710 175 46 increasingly increasingly RB cord-021894-lq8yr710 175 47 precise precise JJ cord-021894-lq8yr710 175 48 and and CC cord-021894-lq8yr710 175 49 cost cost VBP cord-021894-lq8yr710 175 50 effective effective JJ cord-021894-lq8yr710 175 51 . . . cord-021894-lq8yr710 176 1 77 77 CD cord-021894-lq8yr710 177 1 Testing test VBG cord-021894-lq8yr710 177 2 for for IN cord-021894-lq8yr710 177 3 RSV RSV NNP cord-021894-lq8yr710 177 4 ( ( -LRB- cord-021894-lq8yr710 177 5 as as IN cord-021894-lq8yr710 177 6 the the DT cord-021894-lq8yr710 177 7 most most RBS cord-021894-lq8yr710 177 8 common common JJ cord-021894-lq8yr710 177 9 infecting infect VBG cord-021894-lq8yr710 177 10 agent agent NN cord-021894-lq8yr710 177 11 in in IN cord-021894-lq8yr710 177 12 therapies therapy NNS cord-021894-lq8yr710 177 13 in in IN cord-021894-lq8yr710 177 14 addition addition NN cord-021894-lq8yr710 177 15 to to IN cord-021894-lq8yr710 177 16 supplemental supplemental JJ cord-021894-lq8yr710 177 17 oxygen oxygen NN cord-021894-lq8yr710 177 18 and and CC cord-021894-lq8yr710 177 19 hydration hydration NN cord-021894-lq8yr710 177 20 are be VBP cord-021894-lq8yr710 177 21 poorly poorly RB cord-021894-lq8yr710 177 22 supported support VBN cord-021894-lq8yr710 177 23 by by IN cord-021894-lq8yr710 177 24 current current JJ cord-021894-lq8yr710 177 25 evidence evidence NN cord-021894-lq8yr710 177 26 . . . cord-021894-lq8yr710 178 1 There there EX cord-021894-lq8yr710 178 2 is be VBZ cord-021894-lq8yr710 178 3 some some DT cord-021894-lq8yr710 178 4 evidence evidence NN cord-021894-lq8yr710 178 5 that that IN cord-021894-lq8yr710 178 6 infants infant NNS cord-021894-lq8yr710 178 7 handled handle VBD cord-021894-lq8yr710 178 8 less less RBR cord-021894-lq8yr710 178 9 get get VB cord-021894-lq8yr710 178 10 better well JJR cord-021894-lq8yr710 178 11 quicker quick RBR cord-021894-lq8yr710 178 12 , , , cord-021894-lq8yr710 178 13 87 87 CD cord-021894-lq8yr710 178 14 and and CC cord-021894-lq8yr710 178 15 the the DT cord-021894-lq8yr710 178 16 use use NN cord-021894-lq8yr710 178 17 of of IN cord-021894-lq8yr710 178 18 additional additional JJ cord-021894-lq8yr710 178 19 therapies therapy NNS cord-021894-lq8yr710 178 20 should should MD cord-021894-lq8yr710 178 21 be be VB cord-021894-lq8yr710 178 22 considered consider VBN cord-021894-lq8yr710 178 23 with with IN cord-021894-lq8yr710 178 24 that that DT cord-021894-lq8yr710 178 25 in in IN cord-021894-lq8yr710 178 26 mind mind NN cord-021894-lq8yr710 178 27 . . . cord-021894-lq8yr710 179 1 There there EX cord-021894-lq8yr710 179 2 is be VBZ cord-021894-lq8yr710 179 3 widespread widespread JJ cord-021894-lq8yr710 179 4 variation variation NN cord-021894-lq8yr710 179 5 across across IN cord-021894-lq8yr710 179 6 hospitals hospital NNS cord-021894-lq8yr710 179 7 and and CC cord-021894-lq8yr710 179 8 countries country NNS cord-021894-lq8yr710 179 9 in in IN cord-021894-lq8yr710 179 10 the the DT cord-021894-lq8yr710 179 11 management management NN cord-021894-lq8yr710 179 12 and and CC cord-021894-lq8yr710 179 13 treatment treatment NN cord-021894-lq8yr710 179 14 of of IN cord-021894-lq8yr710 179 15 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 179 16 reflecting reflect VBG cord-021894-lq8yr710 179 17 local local JJ cord-021894-lq8yr710 179 18 custom custom NN cord-021894-lq8yr710 179 19 and and CC cord-021894-lq8yr710 179 20 individual individual JJ cord-021894-lq8yr710 179 21 clinician clinician NN cord-021894-lq8yr710 179 22 practice practice NN cord-021894-lq8yr710 179 23 . . . cord-021894-lq8yr710 180 1 88 88 CD cord-021894-lq8yr710 180 2 Reducing reduce VBG cord-021894-lq8yr710 180 3 variation variation NN cord-021894-lq8yr710 180 4 and and CC cord-021894-lq8yr710 180 5 associated associated JJ cord-021894-lq8yr710 180 6 health health NN cord-021894-lq8yr710 180 7 care care NN cord-021894-lq8yr710 180 8 costs cost NNS cord-021894-lq8yr710 180 9 is be VBZ cord-021894-lq8yr710 180 10 a a DT cord-021894-lq8yr710 180 11 key key JJ cord-021894-lq8yr710 180 12 aim aim NN cord-021894-lq8yr710 180 13 of of IN cord-021894-lq8yr710 180 14 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 180 15 management management NN cord-021894-lq8yr710 180 16 presented present VBN cord-021894-lq8yr710 180 17 through through IN cord-021894-lq8yr710 180 18 guidelines guideline NNS cord-021894-lq8yr710 180 19 . . . cord-021894-lq8yr710 181 1 Guidelines guideline NNS cord-021894-lq8yr710 181 2 for for IN cord-021894-lq8yr710 181 3 the the DT cord-021894-lq8yr710 181 4 care care NN cord-021894-lq8yr710 181 5 of of IN cord-021894-lq8yr710 181 6 infants infant NNS cord-021894-lq8yr710 181 7 with with IN cord-021894-lq8yr710 181 8 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 181 9 based base VBN cord-021894-lq8yr710 181 10 on on IN cord-021894-lq8yr710 181 11 systematic systematic JJ cord-021894-lq8yr710 181 12 review review NN cord-021894-lq8yr710 181 13 and and CC cord-021894-lq8yr710 181 14 published publish VBN cord-021894-lq8yr710 181 15 in in IN cord-021894-lq8yr710 181 16 English English NNP cord-021894-lq8yr710 181 17 are be VBP cord-021894-lq8yr710 181 18 available available JJ cord-021894-lq8yr710 181 19 from from IN cord-021894-lq8yr710 181 20 the the DT cord-021894-lq8yr710 181 21 United United NNP cord-021894-lq8yr710 181 22 Kingdom Kingdom NNP cord-021894-lq8yr710 181 23 ( ( -LRB- cord-021894-lq8yr710 181 24 2015 2015 CD cord-021894-lq8yr710 181 25 ) ) -RRB- cord-021894-lq8yr710 181 26 , , , cord-021894-lq8yr710 181 27 89 89 CD cord-021894-lq8yr710 181 28 92 92 CD cord-021894-lq8yr710 181 29 and and CC cord-021894-lq8yr710 181 30 South South NNP cord-021894-lq8yr710 181 31 Africa Africa NNP cord-021894-lq8yr710 181 32 ( ( -LRB- cord-021894-lq8yr710 181 33 2010 2010 CD cord-021894-lq8yr710 181 34 ) ) -RRB- cord-021894-lq8yr710 181 35 , , , cord-021894-lq8yr710 181 36 76 76 CD cord-021894-lq8yr710 181 37 which which WDT cord-021894-lq8yr710 181 38 has have VBZ cord-021894-lq8yr710 181 39 been be VBN cord-021894-lq8yr710 181 40 updated update VBN cord-021894-lq8yr710 181 41 as as IN cord-021894-lq8yr710 181 42 a a DT cord-021894-lq8yr710 181 43 critical critical JJ cord-021894-lq8yr710 181 44 review review NN cord-021894-lq8yr710 181 45 2016 2016 CD cord-021894-lq8yr710 181 46 . . . cord-021894-lq8yr710 182 1 93 93 CD cord-021894-lq8yr710 183 1 No no DT cord-021894-lq8yr710 183 2 therapies therapy NNS cord-021894-lq8yr710 183 3 receive receive VBP cord-021894-lq8yr710 183 4 support support NN cord-021894-lq8yr710 183 5 across across IN cord-021894-lq8yr710 183 6 all all DT cord-021894-lq8yr710 183 7 guidelines guideline NNS cord-021894-lq8yr710 183 8 for for IN cord-021894-lq8yr710 183 9 use use NN cord-021894-lq8yr710 183 10 with with IN cord-021894-lq8yr710 183 11 the the DT cord-021894-lq8yr710 183 12 exception exception NN cord-021894-lq8yr710 183 13 of of IN cord-021894-lq8yr710 183 14 supplemental supplemental JJ cord-021894-lq8yr710 183 15 oxygen oxygen NN cord-021894-lq8yr710 183 16 . . . cord-021894-lq8yr710 184 1 Chest chest NN cord-021894-lq8yr710 184 2 physiotherapy physiotherapy NN cord-021894-lq8yr710 184 3 does do VBZ cord-021894-lq8yr710 184 4 not not RB cord-021894-lq8yr710 184 5 speed speed VB cord-021894-lq8yr710 184 6 recovery recovery NN cord-021894-lq8yr710 184 7 . . . cord-021894-lq8yr710 185 1 Antibiotics antibiotic NNS cord-021894-lq8yr710 185 2 , , , cord-021894-lq8yr710 185 3 though though IN cord-021894-lq8yr710 185 4 still still RB cord-021894-lq8yr710 185 5 widely widely RB cord-021894-lq8yr710 185 6 used use VBN cord-021894-lq8yr710 185 7 , , , cord-021894-lq8yr710 185 8 are be VBP cord-021894-lq8yr710 185 9 of of IN cord-021894-lq8yr710 185 10 no no DT cord-021894-lq8yr710 185 11 benefit benefit NN cord-021894-lq8yr710 185 12 in in IN cord-021894-lq8yr710 185 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 185 14 . . . cord-021894-lq8yr710 186 1 79 79 CD cord-021894-lq8yr710 187 1 In in IN cord-021894-lq8yr710 187 2 addition addition NN cord-021894-lq8yr710 187 3 , , , cord-021894-lq8yr710 187 4 bronchodilators bronchodilator NNS cord-021894-lq8yr710 187 5 are be VBP cord-021894-lq8yr710 187 6 less less RBR cord-021894-lq8yr710 187 7 likely likely JJ cord-021894-lq8yr710 187 8 to to TO cord-021894-lq8yr710 187 9 be be VB cord-021894-lq8yr710 187 10 recommended recommend VBN cord-021894-lq8yr710 187 11 in in IN cord-021894-lq8yr710 187 12 more more JJR cord-021894-lq8yr710 187 13 recent recent JJ cord-021894-lq8yr710 187 14 guidelines guideline NNS cord-021894-lq8yr710 187 15 , , , cord-021894-lq8yr710 187 16 and and CC cord-021894-lq8yr710 187 17 the the DT cord-021894-lq8yr710 187 18 theory theory NN cord-021894-lq8yr710 187 19 that that IN cord-021894-lq8yr710 187 20 they -PRON- PRP cord-021894-lq8yr710 187 21 may may MD cord-021894-lq8yr710 187 22 be be VB cord-021894-lq8yr710 187 23 of of IN cord-021894-lq8yr710 187 24 greater great JJR cord-021894-lq8yr710 187 25 benefit benefit NN cord-021894-lq8yr710 187 26 in in IN cord-021894-lq8yr710 187 27 infants infant NNS cord-021894-lq8yr710 187 28 more more RBR cord-021894-lq8yr710 187 29 likely likely JJ cord-021894-lq8yr710 187 30 to to TO cord-021894-lq8yr710 187 31 develop develop VB cord-021894-lq8yr710 187 32 asthma asthma NN cord-021894-lq8yr710 187 33 has have VBZ cord-021894-lq8yr710 187 34 been be VBN cord-021894-lq8yr710 187 35 refuted refute VBN cord-021894-lq8yr710 187 36 . . . cord-021894-lq8yr710 188 1 94 94 CD cord-021894-lq8yr710 188 2 Nebulized Nebulized NNP cord-021894-lq8yr710 188 3 hypertonic hypertonic JJ cord-021894-lq8yr710 188 4 saline saline NN cord-021894-lq8yr710 188 5 has have VBZ cord-021894-lq8yr710 188 6 been be VBN cord-021894-lq8yr710 188 7 of of IN cord-021894-lq8yr710 188 8 benefit benefit NN cord-021894-lq8yr710 188 9 in in IN cord-021894-lq8yr710 188 10 cystic cystic JJ cord-021894-lq8yr710 188 11 fibrosis fibrosis NN cord-021894-lq8yr710 188 12 and and CC cord-021894-lq8yr710 188 13 in in IN cord-021894-lq8yr710 188 14 early early JJ cord-021894-lq8yr710 188 15 trials trial NNS cord-021894-lq8yr710 188 16 in in IN cord-021894-lq8yr710 188 17 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 188 18 , , , cord-021894-lq8yr710 188 19 95 95 CD cord-021894-lq8yr710 188 20 but but CC cord-021894-lq8yr710 188 21 larger large JJR cord-021894-lq8yr710 188 22 well well RB cord-021894-lq8yr710 188 23 - - HYPH cord-021894-lq8yr710 188 24 designed design VBN cord-021894-lq8yr710 188 25 trials trial NNS cord-021894-lq8yr710 188 26 have have VBP cord-021894-lq8yr710 188 27 not not RB cord-021894-lq8yr710 188 28 demonstrated demonstrate VBN cord-021894-lq8yr710 188 29 a a DT cord-021894-lq8yr710 188 30 persuasive persuasive JJ cord-021894-lq8yr710 188 31 benefit benefit NN cord-021894-lq8yr710 188 32 . . . cord-021894-lq8yr710 189 1 [ [ -LRB- cord-021894-lq8yr710 189 2 96 96 CD cord-021894-lq8yr710 189 3 ] ] -RRB- cord-021894-lq8yr710 189 4 [ [ -LRB- cord-021894-lq8yr710 189 5 97 97 CD cord-021894-lq8yr710 189 6 ] ] -RRB- cord-021894-lq8yr710 189 7 [ [ -LRB- cord-021894-lq8yr710 189 8 98 98 CD cord-021894-lq8yr710 189 9 ] ] -RRB- cord-021894-lq8yr710 190 1 [ [ -LRB- cord-021894-lq8yr710 190 2 99 99 CD cord-021894-lq8yr710 190 3 ] ] -RRB- cord-021894-lq8yr710 191 1 [ [ -LRB- cord-021894-lq8yr710 191 2 100 100 CD cord-021894-lq8yr710 191 3 ] ] -RRB- cord-021894-lq8yr710 192 1 Recent recent JJ cord-021894-lq8yr710 192 2 years year NNS cord-021894-lq8yr710 192 3 have have VBP cord-021894-lq8yr710 192 4 seen see VBN cord-021894-lq8yr710 192 5 the the DT cord-021894-lq8yr710 192 6 increasing increase VBG cord-021894-lq8yr710 192 7 use use NN cord-021894-lq8yr710 192 8 of of IN cord-021894-lq8yr710 192 9 HFNC HFNC NNP cord-021894-lq8yr710 192 10 oxygen oxygen NN cord-021894-lq8yr710 192 11 in in IN cord-021894-lq8yr710 192 12 acute acute JJ cord-021894-lq8yr710 192 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 192 14 . . . cord-021894-lq8yr710 193 1 101 101 CD cord-021894-lq8yr710 194 1 Though though IN cord-021894-lq8yr710 194 2 clinical clinical JJ cord-021894-lq8yr710 194 3 trials trial NNS cord-021894-lq8yr710 194 4 have have VBP cord-021894-lq8yr710 194 5 not not RB cord-021894-lq8yr710 194 6 yet yet RB cord-021894-lq8yr710 194 7 demonstrated demonstrate VBN cord-021894-lq8yr710 194 8 important important JJ cord-021894-lq8yr710 194 9 clinical clinical JJ cord-021894-lq8yr710 194 10 or or CC cord-021894-lq8yr710 194 11 physiological physiological JJ cord-021894-lq8yr710 194 12 benefits benefit NNS cord-021894-lq8yr710 194 13 , , , cord-021894-lq8yr710 194 14 102 102 CD cord-021894-lq8yr710 194 15 large large JJ cord-021894-lq8yr710 194 16 well well RB cord-021894-lq8yr710 194 17 - - HYPH cord-021894-lq8yr710 194 18 designed design VBN cord-021894-lq8yr710 194 19 trials trial NNS cord-021894-lq8yr710 194 20 are be VBP cord-021894-lq8yr710 194 21 in in IN cord-021894-lq8yr710 194 22 progress progress NN cord-021894-lq8yr710 194 23 and and CC cord-021894-lq8yr710 194 24 are be VBP cord-021894-lq8yr710 194 25 beginning begin VBG cord-021894-lq8yr710 194 26 to to TO cord-021894-lq8yr710 194 27 report report VB cord-021894-lq8yr710 194 28 . . . cord-021894-lq8yr710 195 1 102a,103 102a,103 LS cord-021894-lq8yr710 195 2 CPAP CPAP NNP cord-021894-lq8yr710 195 3 has have VBZ cord-021894-lq8yr710 195 4 some some DT cord-021894-lq8yr710 195 5 benefit benefit NN cord-021894-lq8yr710 195 6 in in IN cord-021894-lq8yr710 195 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 195 8 , , , cord-021894-lq8yr710 195 9 and and CC cord-021894-lq8yr710 195 10 may may MD cord-021894-lq8yr710 195 11 prevent prevent VB cord-021894-lq8yr710 195 12 deterioration deterioration NN cord-021894-lq8yr710 195 13 when when WRB cord-021894-lq8yr710 195 14 used use VBN cord-021894-lq8yr710 195 15 early early RB cord-021894-lq8yr710 195 16 . . . cord-021894-lq8yr710 196 1 104 104 CD cord-021894-lq8yr710 197 1 As as IN cord-021894-lq8yr710 197 2 with with IN cord-021894-lq8yr710 197 3 all all DT cord-021894-lq8yr710 197 4 management management NN cord-021894-lq8yr710 197 5 in in IN cord-021894-lq8yr710 197 6 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 197 7 , , , cord-021894-lq8yr710 197 8 the the DT cord-021894-lq8yr710 197 9 use use NN cord-021894-lq8yr710 197 10 of of IN cord-021894-lq8yr710 197 11 HFNC HFNC NNP cord-021894-lq8yr710 197 12 oxygen oxygen NN cord-021894-lq8yr710 197 13 , , , cord-021894-lq8yr710 197 14 CPAP CPAP NNP cord-021894-lq8yr710 197 15 , , , cord-021894-lq8yr710 197 16 and and CC cord-021894-lq8yr710 197 17 intubation intubation NN cord-021894-lq8yr710 197 18 varies vary VBZ cord-021894-lq8yr710 197 19 across across IN cord-021894-lq8yr710 197 20 sites site NNS cord-021894-lq8yr710 197 21 irrespective irrespective RB cord-021894-lq8yr710 197 22 of of IN cord-021894-lq8yr710 197 23 disease disease NN cord-021894-lq8yr710 197 24 severity severity NN cord-021894-lq8yr710 197 25 , , , cord-021894-lq8yr710 197 26 105 105 CD cord-021894-lq8yr710 197 27 and and CC cord-021894-lq8yr710 197 28 better well JJR cord-021894-lq8yr710 197 29 understanding understanding NN cord-021894-lq8yr710 197 30 of of IN cord-021894-lq8yr710 197 31 the the DT cord-021894-lq8yr710 197 32 risks risk NNS cord-021894-lq8yr710 197 33 and and CC cord-021894-lq8yr710 197 34 benefits benefit NNS cord-021894-lq8yr710 197 35 of of IN cord-021894-lq8yr710 197 36 these these DT cord-021894-lq8yr710 197 37 interventions intervention NNS cord-021894-lq8yr710 197 38 is be VBZ cord-021894-lq8yr710 197 39 required require VBN cord-021894-lq8yr710 197 40 . . . cord-021894-lq8yr710 198 1 106 106 CD cord-021894-lq8yr710 199 1 There there EX cord-021894-lq8yr710 199 2 are be VBP cord-021894-lq8yr710 199 3 no no DT cord-021894-lq8yr710 199 4 current current JJ cord-021894-lq8yr710 199 5 effective effective JJ cord-021894-lq8yr710 199 6 pharmacological pharmacological JJ cord-021894-lq8yr710 199 7 treatments treatment NNS cord-021894-lq8yr710 199 8 for for IN cord-021894-lq8yr710 199 9 RSV RSV NNP cord-021894-lq8yr710 199 10 . . . cord-021894-lq8yr710 200 1 While while IN cord-021894-lq8yr710 200 2 ribavirin ribavirin NN cord-021894-lq8yr710 200 3 was be VBD cord-021894-lq8yr710 200 4 previously previously RB cord-021894-lq8yr710 200 5 used use VBN cord-021894-lq8yr710 200 6 as as IN cord-021894-lq8yr710 200 7 an an DT cord-021894-lq8yr710 200 8 antiviral antiviral JJ cord-021894-lq8yr710 200 9 treatment treatment NN cord-021894-lq8yr710 200 10 for for IN cord-021894-lq8yr710 200 11 RSV RSV NNP cord-021894-lq8yr710 200 12 , , , cord-021894-lq8yr710 200 13 it -PRON- PRP cord-021894-lq8yr710 200 14 is be VBZ cord-021894-lq8yr710 200 15 now now RB cord-021894-lq8yr710 200 16 considered consider VBN cord-021894-lq8yr710 200 17 ineffective ineffective JJ cord-021894-lq8yr710 200 18 . . . cord-021894-lq8yr710 201 1 107 107 CD cord-021894-lq8yr710 202 1 Novel novel JJ cord-021894-lq8yr710 202 2 treatments treatment NNS cord-021894-lq8yr710 202 3 for for IN cord-021894-lq8yr710 202 4 acute acute JJ cord-021894-lq8yr710 202 5 infection infection NN cord-021894-lq8yr710 202 6 are be VBP cord-021894-lq8yr710 202 7 in in IN cord-021894-lq8yr710 202 8 development development NN cord-021894-lq8yr710 202 9 : : : cord-021894-lq8yr710 202 10 antivirals antiviral NNS cord-021894-lq8yr710 202 11 and and CC cord-021894-lq8yr710 202 12 nebulized nebulize VBN cord-021894-lq8yr710 202 13 immunoglobulin immunoglobulin NN cord-021894-lq8yr710 202 14 . . . cord-021894-lq8yr710 203 1 In in IN cord-021894-lq8yr710 203 2 this this DT cord-021894-lq8yr710 203 3 rapidly rapidly RB cord-021894-lq8yr710 203 4 moving move VBG cord-021894-lq8yr710 203 5 field field NN cord-021894-lq8yr710 203 6 , , , cord-021894-lq8yr710 203 7 it -PRON- PRP cord-021894-lq8yr710 203 8 seems seem VBZ cord-021894-lq8yr710 203 9 probable probable JJ cord-021894-lq8yr710 203 10 that that IN cord-021894-lq8yr710 203 11 a a DT cord-021894-lq8yr710 203 12 treatment treatment NN cord-021894-lq8yr710 203 13 for for IN cord-021894-lq8yr710 203 14 RSV RSV NNP cord-021894-lq8yr710 203 15 will will MD cord-021894-lq8yr710 203 16 become become VB cord-021894-lq8yr710 203 17 available available JJ cord-021894-lq8yr710 203 18 in in IN cord-021894-lq8yr710 203 19 the the DT cord-021894-lq8yr710 203 20 next next JJ cord-021894-lq8yr710 203 21 5 5 CD cord-021894-lq8yr710 203 22 years year NNS cord-021894-lq8yr710 203 23 . . . cord-021894-lq8yr710 204 1 108 108 CD cord-021894-lq8yr710 204 2 Reduction reduction NN cord-021894-lq8yr710 204 3 in in IN cord-021894-lq8yr710 204 4 viral viral JJ cord-021894-lq8yr710 204 5 load load NN cord-021894-lq8yr710 204 6 has have VBZ cord-021894-lq8yr710 204 7 been be VBN cord-021894-lq8yr710 204 8 demonstrated demonstrate VBN cord-021894-lq8yr710 204 9 in in IN cord-021894-lq8yr710 204 10 adult adult NN cord-021894-lq8yr710 204 11 challenge challenge NN cord-021894-lq8yr710 204 12 models model NNS cord-021894-lq8yr710 204 13 of of IN cord-021894-lq8yr710 204 14 RSV RSV NNP cord-021894-lq8yr710 204 15 treated treat VBN cord-021894-lq8yr710 204 16 with with IN cord-021894-lq8yr710 204 17 the the DT cord-021894-lq8yr710 204 18 antivirals antiviral NNS cord-021894-lq8yr710 205 1 ALS-8176 als-8176 $ cord-021894-lq8yr710 205 2 109 109 CD cord-021894-lq8yr710 205 3 and and CC cord-021894-lq8yr710 205 4 GS-5806 GS-5806 VBN cord-021894-lq8yr710 205 5 110 110 CD cord-021894-lq8yr710 205 6 Prevention Prevention NNP cord-021894-lq8yr710 205 7 of of IN cord-021894-lq8yr710 205 8 spread spread NN cord-021894-lq8yr710 205 9 of of IN cord-021894-lq8yr710 205 10 RSV RSV NNP cord-021894-lq8yr710 205 11 depends depend VBZ cord-021894-lq8yr710 205 12 on on IN cord-021894-lq8yr710 205 13 good good JJ cord-021894-lq8yr710 205 14 hygiene hygiene NN cord-021894-lq8yr710 205 15 , , , cord-021894-lq8yr710 205 16 in in IN cord-021894-lq8yr710 205 17 particular particular JJ cord-021894-lq8yr710 205 18 , , , cord-021894-lq8yr710 205 19 hand hand NN cord-021894-lq8yr710 205 20 washing washing NN cord-021894-lq8yr710 205 21 , , , cord-021894-lq8yr710 205 22 as as IN cord-021894-lq8yr710 205 23 RSV RSV NNP cord-021894-lq8yr710 205 24 may may MD cord-021894-lq8yr710 205 25 survive survive VB cord-021894-lq8yr710 205 26 for for IN cord-021894-lq8yr710 205 27 up up IN cord-021894-lq8yr710 205 28 to to TO cord-021894-lq8yr710 205 29 6 6 CD cord-021894-lq8yr710 205 30 hours hour NNS cord-021894-lq8yr710 205 31 on on IN cord-021894-lq8yr710 205 32 surfaces surface NNS cord-021894-lq8yr710 205 33 contaminated contaminate VBN cord-021894-lq8yr710 205 34 by by IN cord-021894-lq8yr710 205 35 droplets droplet NNS cord-021894-lq8yr710 205 36 . . . cord-021894-lq8yr710 206 1 111 111 CD cord-021894-lq8yr710 207 1 Similar similar JJ cord-021894-lq8yr710 207 2 precautions precaution NNS cord-021894-lq8yr710 207 3 are be VBP cord-021894-lq8yr710 207 4 appropriate appropriate JJ cord-021894-lq8yr710 207 5 for for IN cord-021894-lq8yr710 207 6 other other JJ cord-021894-lq8yr710 207 7 respiratory respiratory JJ cord-021894-lq8yr710 207 8 virus virus NN cord-021894-lq8yr710 207 9 infections infection NNS cord-021894-lq8yr710 207 10 associated associate VBN cord-021894-lq8yr710 207 11 with with IN cord-021894-lq8yr710 207 12 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 207 13 . . . cord-021894-lq8yr710 208 1 Many many JJ cord-021894-lq8yr710 208 2 hospitals hospital NNS cord-021894-lq8yr710 208 3 use use VBP cord-021894-lq8yr710 208 4 PoC PoC NNP cord-021894-lq8yr710 208 5 testing testing NN cord-021894-lq8yr710 208 6 for for IN cord-021894-lq8yr710 208 7 RSV RSV NNP cord-021894-lq8yr710 208 8 to to TO cord-021894-lq8yr710 208 9 determine determine VB cord-021894-lq8yr710 208 10 cohorting cohorting NN cord-021894-lq8yr710 208 11 of of IN cord-021894-lq8yr710 208 12 infants infant NNS cord-021894-lq8yr710 208 13 as as IN cord-021894-lq8yr710 208 14 inpatients inpatient NNS cord-021894-lq8yr710 208 15 . . . cord-021894-lq8yr710 209 1 107 107 CD cord-021894-lq8yr710 210 1 While while IN cord-021894-lq8yr710 210 2 this this DT cord-021894-lq8yr710 210 3 is be VBZ cord-021894-lq8yr710 210 4 still still RB cord-021894-lq8yr710 210 5 common common JJ cord-021894-lq8yr710 210 6 , , , cord-021894-lq8yr710 210 7 the the DT cord-021894-lq8yr710 210 8 practice practice NN cord-021894-lq8yr710 210 9 is be VBZ cord-021894-lq8yr710 210 10 called call VBN cord-021894-lq8yr710 210 11 into into IN cord-021894-lq8yr710 210 12 question question NN cord-021894-lq8yr710 210 13 by by IN cord-021894-lq8yr710 210 14 the the DT cord-021894-lq8yr710 210 15 range range NN cord-021894-lq8yr710 210 16 of of IN cord-021894-lq8yr710 210 17 coinfection coinfection NN cord-021894-lq8yr710 210 18 with with IN cord-021894-lq8yr710 210 19 other other JJ cord-021894-lq8yr710 210 20 respiratory respiratory JJ cord-021894-lq8yr710 210 21 viruses virus NNS cord-021894-lq8yr710 210 22 revealed reveal VBN cord-021894-lq8yr710 210 23 by by IN cord-021894-lq8yr710 210 24 PCR PCR NNP cord-021894-lq8yr710 210 25 panel panel NN cord-021894-lq8yr710 210 26 testing testing NN cord-021894-lq8yr710 210 27 ; ; : cord-021894-lq8yr710 210 28 up up IN cord-021894-lq8yr710 210 29 to to TO cord-021894-lq8yr710 210 30 62 62 CD cord-021894-lq8yr710 210 31 % % NN cord-021894-lq8yr710 210 32 of of IN cord-021894-lq8yr710 210 33 children child NNS cord-021894-lq8yr710 210 34 with with IN cord-021894-lq8yr710 210 35 viral viral JJ cord-021894-lq8yr710 210 36 respiratory respiratory JJ cord-021894-lq8yr710 210 37 tract tract NN cord-021894-lq8yr710 210 38 infection infection NN cord-021894-lq8yr710 210 39 have have VBP cord-021894-lq8yr710 210 40 more more JJR cord-021894-lq8yr710 210 41 than than IN cord-021894-lq8yr710 210 42 one one CD cord-021894-lq8yr710 210 43 virus virus NN cord-021894-lq8yr710 210 44 detected detect VBD cord-021894-lq8yr710 210 45 . . . cord-021894-lq8yr710 211 1 112 112 CD cord-021894-lq8yr710 211 2 Prevention Prevention NNP cord-021894-lq8yr710 211 3 of of IN cord-021894-lq8yr710 211 4 RSV RSV NNP cord-021894-lq8yr710 211 5 ( ( -LRB- cord-021894-lq8yr710 211 6 as as IN cord-021894-lq8yr710 211 7 the the DT cord-021894-lq8yr710 211 8 most most RBS cord-021894-lq8yr710 211 9 common common JJ cord-021894-lq8yr710 211 10 cause cause NN cord-021894-lq8yr710 211 11 of of IN cord-021894-lq8yr710 211 12 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 211 13 ) ) -RRB- cord-021894-lq8yr710 211 14 has have VBZ cord-021894-lq8yr710 211 15 been be VBN cord-021894-lq8yr710 211 16 a a DT cord-021894-lq8yr710 211 17 long long JJ cord-021894-lq8yr710 211 18 - - HYPH cord-021894-lq8yr710 211 19 term term NN cord-021894-lq8yr710 211 20 goal goal NN cord-021894-lq8yr710 211 21 . . . cord-021894-lq8yr710 212 1 Early early JJ cord-021894-lq8yr710 212 2 formalin formalin NN cord-021894-lq8yr710 212 3 inactivated inactivate VBN cord-021894-lq8yr710 213 1 There there EX cord-021894-lq8yr710 213 2 are be VBP cord-021894-lq8yr710 213 3 no no DT cord-021894-lq8yr710 213 4 trials trial NNS cord-021894-lq8yr710 213 5 of of IN cord-021894-lq8yr710 213 6 outcome outcome NN cord-021894-lq8yr710 213 7 for for IN cord-021894-lq8yr710 213 8 antibiotic antibiotic JJ cord-021894-lq8yr710 213 9 use use NN cord-021894-lq8yr710 213 10 in in IN cord-021894-lq8yr710 213 11 children child NNS cord-021894-lq8yr710 213 12 with with IN cord-021894-lq8yr710 213 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 213 14 receiving receive VBG cord-021894-lq8yr710 213 15 intensive intensive JJ cord-021894-lq8yr710 213 16 care care NN cord-021894-lq8yr710 213 17 . . . cord-021894-lq8yr710 214 1 Though though IN cord-021894-lq8yr710 214 2 uncommon uncommon JJ cord-021894-lq8yr710 214 3 , , , cord-021894-lq8yr710 214 4 congenital congenital JJ cord-021894-lq8yr710 214 5 lesions lesion NNS cord-021894-lq8yr710 214 6 may may MD cord-021894-lq8yr710 214 7 masquerade masquerade VB cord-021894-lq8yr710 214 8 as as IN cord-021894-lq8yr710 214 9 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 214 10 , , , cord-021894-lq8yr710 214 11 and and CC cord-021894-lq8yr710 214 12 this this DT cord-021894-lq8yr710 214 13 should should MD cord-021894-lq8yr710 214 14 be be VB cord-021894-lq8yr710 214 15 borne bear VBN cord-021894-lq8yr710 214 16 in in IN cord-021894-lq8yr710 214 17 mind mind NN cord-021894-lq8yr710 214 18 for for IN cord-021894-lq8yr710 214 19 children child NNS cord-021894-lq8yr710 214 20 with with IN cord-021894-lq8yr710 214 21 atypical atypical JJ cord-021894-lq8yr710 214 22 clinical clinical JJ cord-021894-lq8yr710 214 23 features feature NNS cord-021894-lq8yr710 214 24 or or CC cord-021894-lq8yr710 214 25 those those DT cord-021894-lq8yr710 214 26 slow slow JJ cord-021894-lq8yr710 214 27 to to TO cord-021894-lq8yr710 214 28 recover recover VB cord-021894-lq8yr710 214 29 . . . cord-021894-lq8yr710 215 1 Congenital congenital JJ cord-021894-lq8yr710 215 2 heart heart NN cord-021894-lq8yr710 215 3 disease disease NN cord-021894-lq8yr710 215 4 may may MD cord-021894-lq8yr710 215 5 present present VB cord-021894-lq8yr710 215 6 as as IN cord-021894-lq8yr710 215 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 215 8 when when WRB cord-021894-lq8yr710 215 9 pulmonary pulmonary JJ cord-021894-lq8yr710 215 10 vascular vascular JJ cord-021894-lq8yr710 215 11 resistance resistance NN cord-021894-lq8yr710 215 12 falls fall VBZ cord-021894-lq8yr710 215 13 increasing increase VBG cord-021894-lq8yr710 215 14 left leave VBN cord-021894-lq8yr710 215 15 to to IN cord-021894-lq8yr710 215 16 right right JJ cord-021894-lq8yr710 215 17 shunt shunt NN cord-021894-lq8yr710 215 18 . . . cord-021894-lq8yr710 216 1 More more RBR cord-021894-lq8yr710 216 2 difficult difficult JJ cord-021894-lq8yr710 216 3 to to TO cord-021894-lq8yr710 216 4 differentiate differentiate VB cord-021894-lq8yr710 216 5 are be VBP cord-021894-lq8yr710 216 6 children child NNS cord-021894-lq8yr710 216 7 with with IN cord-021894-lq8yr710 216 8 congenital congenital JJ cord-021894-lq8yr710 216 9 ( ( -LRB- cord-021894-lq8yr710 216 10 or or CC cord-021894-lq8yr710 216 11 less less RBR cord-021894-lq8yr710 216 12 commonly commonly RB cord-021894-lq8yr710 216 13 acquired acquire VBN cord-021894-lq8yr710 216 14 ) ) -RRB- cord-021894-lq8yr710 216 15 pulmonary pulmonary JJ cord-021894-lq8yr710 216 16 malformations malformation NNS cord-021894-lq8yr710 216 17 . . . cord-021894-lq8yr710 217 1 Fixed fix VBN cord-021894-lq8yr710 217 2 focal focal JJ cord-021894-lq8yr710 217 3 wheeze wheeze NN cord-021894-lq8yr710 217 4 may may MD cord-021894-lq8yr710 217 5 be be VB cord-021894-lq8yr710 217 6 a a DT cord-021894-lq8yr710 217 7 sign sign NN cord-021894-lq8yr710 217 8 of of IN cord-021894-lq8yr710 217 9 tracheomalacia tracheomalacia NNS cord-021894-lq8yr710 217 10 or or CC cord-021894-lq8yr710 217 11 bronchomalacia bronchomalacia NN cord-021894-lq8yr710 217 12 , , , cord-021894-lq8yr710 217 13 stenosis stenosis NN cord-021894-lq8yr710 217 14 , , , cord-021894-lq8yr710 217 15 or or CC cord-021894-lq8yr710 217 16 compression compression NN cord-021894-lq8yr710 217 17 from from IN cord-021894-lq8yr710 217 18 lobar lobar JJ cord-021894-lq8yr710 217 19 emphysema emphysema NN cord-021894-lq8yr710 217 20 or or CC cord-021894-lq8yr710 217 21 a a DT cord-021894-lq8yr710 217 22 bronchogenic bronchogenic JJ cord-021894-lq8yr710 217 23 cyst cyst NN cord-021894-lq8yr710 217 24 and and CC cord-021894-lq8yr710 217 25 would would MD cord-021894-lq8yr710 217 26 warrant warrant VB cord-021894-lq8yr710 217 27 a a DT cord-021894-lq8yr710 217 28 chest chest NN cord-021894-lq8yr710 217 29 radiograph radiograph NN cord-021894-lq8yr710 217 30 . . . cord-021894-lq8yr710 218 1 A a DT cord-021894-lq8yr710 218 2 slow slow JJ cord-021894-lq8yr710 218 3 recovering recovering NN cord-021894-lq8yr710 218 4 course course NN cord-021894-lq8yr710 218 5 with with IN cord-021894-lq8yr710 218 6 persistent persistent JJ cord-021894-lq8yr710 218 7 chest chest NN cord-021894-lq8yr710 218 8 signs sign NNS cord-021894-lq8yr710 218 9 could could MD cord-021894-lq8yr710 218 10 be be VB cord-021894-lq8yr710 218 11 an an DT cord-021894-lq8yr710 218 12 infected infected JJ cord-021894-lq8yr710 218 13 congenital congenital JJ cord-021894-lq8yr710 218 14 pulmonary pulmonary JJ cord-021894-lq8yr710 218 15 malformation malformation NN cord-021894-lq8yr710 218 16 ( ( -LRB- cord-021894-lq8yr710 218 17 such such JJ cord-021894-lq8yr710 218 18 as as IN cord-021894-lq8yr710 218 19 a a DT cord-021894-lq8yr710 218 20 congenital congenital JJ cord-021894-lq8yr710 218 21 cystic cystic JJ cord-021894-lq8yr710 218 22 adenomatoid adenomatoid NN cord-021894-lq8yr710 218 23 malformation malformation NN cord-021894-lq8yr710 218 24 [ [ -LRB- cord-021894-lq8yr710 218 25 CCAM CCAM NNP cord-021894-lq8yr710 218 26 ] ] -RRB- cord-021894-lq8yr710 218 27 or or CC cord-021894-lq8yr710 218 28 sequestration sequestration NN cord-021894-lq8yr710 218 29 ) ) -RRB- cord-021894-lq8yr710 218 30 . . . cord-021894-lq8yr710 219 1 Children child NNS cord-021894-lq8yr710 219 2 with with IN cord-021894-lq8yr710 219 3 persistent persistent JJ cord-021894-lq8yr710 219 4 fine fine JJ cord-021894-lq8yr710 219 5 crackles crackle NNS cord-021894-lq8yr710 219 6 , , , cord-021894-lq8yr710 219 7 tachypnea tachypnea NNP cord-021894-lq8yr710 219 8 , , , cord-021894-lq8yr710 219 9 and and CC cord-021894-lq8yr710 219 10 low low JJ cord-021894-lq8yr710 219 11 ( ( -LRB- cord-021894-lq8yr710 219 12 often often RB cord-021894-lq8yr710 219 13 borderline borderline JJ cord-021894-lq8yr710 219 14 ) ) -RRB- cord-021894-lq8yr710 220 1 oxygen oxygen NN cord-021894-lq8yr710 220 2 saturation saturation NN cord-021894-lq8yr710 220 3 may may MD cord-021894-lq8yr710 220 4 have have VB cord-021894-lq8yr710 220 5 an an DT cord-021894-lq8yr710 220 6 interstitial interstitial JJ cord-021894-lq8yr710 220 7 lung lung NN cord-021894-lq8yr710 220 8 disease disease NN cord-021894-lq8yr710 220 9 , , , cord-021894-lq8yr710 220 10 particularly particularly RB cord-021894-lq8yr710 220 11 neuroendocrine neuroendocrine JJ cord-021894-lq8yr710 220 12 cell cell NN cord-021894-lq8yr710 220 13 hyperplasia hyperplasia NN cord-021894-lq8yr710 220 14 ( ( -LRB- cord-021894-lq8yr710 220 15 NEHI NEHI NNP cord-021894-lq8yr710 220 16 ) ) -RRB- cord-021894-lq8yr710 220 17 presenting present VBG cord-021894-lq8yr710 220 18 as as IN cord-021894-lq8yr710 220 19 recurrent recurrent JJ cord-021894-lq8yr710 220 20 " " `` cord-021894-lq8yr710 220 21 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 220 22 . . . cord-021894-lq8yr710 220 23 " " '' cord-021894-lq8yr710 221 1 Young young JJ cord-021894-lq8yr710 221 2 children child NNS cord-021894-lq8yr710 221 3 with with IN cord-021894-lq8yr710 221 4 persistent persistent JJ cord-021894-lq8yr710 221 5 , , , cord-021894-lq8yr710 221 6 sometimes sometimes RB cord-021894-lq8yr710 221 7 focal focal JJ cord-021894-lq8yr710 221 8 , , , cord-021894-lq8yr710 221 9 crackles crackle VBZ cord-021894-lq8yr710 221 10 postadenovirus postadenovirus NNP cord-021894-lq8yr710 221 11 ( ( -LRB- cord-021894-lq8yr710 221 12 though though IN cord-021894-lq8yr710 221 13 may may MD cord-021894-lq8yr710 221 14 also also RB cord-021894-lq8yr710 221 15 be be VB cord-021894-lq8yr710 221 16 other other JJ cord-021894-lq8yr710 221 17 respiratory respiratory JJ cord-021894-lq8yr710 221 18 viruses virus NNS cord-021894-lq8yr710 221 19 and and CC cord-021894-lq8yr710 221 20 mycoplasma mycoplasma NN cord-021894-lq8yr710 221 21 pneumonia pneumonia NN cord-021894-lq8yr710 221 22 ) ) -RRB- cord-021894-lq8yr710 221 23 should should MD cord-021894-lq8yr710 221 24 be be VB cord-021894-lq8yr710 221 25 evaluated evaluate VBN cord-021894-lq8yr710 221 26 for for IN cord-021894-lq8yr710 221 27 postinfectious postinfectious NNP cord-021894-lq8yr710 221 28 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 221 29 obliterans obliterans NNP cord-021894-lq8yr710 221 30 ( ( -LRB- cord-021894-lq8yr710 221 31 PIBO PIBO NNP cord-021894-lq8yr710 221 32 ) ) -RRB- cord-021894-lq8yr710 221 33 ; ; : cord-021894-lq8yr710 221 34 see see VB cord-021894-lq8yr710 221 35 section section NN cord-021894-lq8yr710 221 36 6 6 CD cord-021894-lq8yr710 221 37 of of IN cord-021894-lq8yr710 221 38 the the DT cord-021894-lq8yr710 221 39 book book NN cord-021894-lq8yr710 221 40 . . . cord-021894-lq8yr710 222 1 Management management NN cord-021894-lq8yr710 222 2 of of IN cord-021894-lq8yr710 222 3 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 222 4 is be VBZ cord-021894-lq8yr710 222 5 supportive supportive JJ cord-021894-lq8yr710 222 6 , , , cord-021894-lq8yr710 222 7 assisting assist VBG cord-021894-lq8yr710 222 8 hydration hydration NN cord-021894-lq8yr710 222 9 and and CC cord-021894-lq8yr710 222 10 hypoxemia hypoxemia NN cord-021894-lq8yr710 222 11 until until IN cord-021894-lq8yr710 222 12 improvement improvement NN cord-021894-lq8yr710 222 13 . . . cord-021894-lq8yr710 223 1 With with IN cord-021894-lq8yr710 223 2 increased increase VBN cord-021894-lq8yr710 223 3 respiratory respiratory JJ cord-021894-lq8yr710 223 4 rate rate NN cord-021894-lq8yr710 223 5 and and CC cord-021894-lq8yr710 223 6 nasal nasal NN cord-021894-lq8yr710 223 7 secretions secretion NNS cord-021894-lq8yr710 223 8 , , , cord-021894-lq8yr710 223 9 oral oral JJ cord-021894-lq8yr710 223 10 feeding feeding NN cord-021894-lq8yr710 223 11 is be VBZ cord-021894-lq8yr710 223 12 challenged challenge VBN cord-021894-lq8yr710 223 13 , , , cord-021894-lq8yr710 223 14 and and CC cord-021894-lq8yr710 223 15 those those DT cord-021894-lq8yr710 223 16 with with IN cord-021894-lq8yr710 223 17 severe severe JJ cord-021894-lq8yr710 223 18 disease disease NN cord-021894-lq8yr710 223 19 require require VBP cord-021894-lq8yr710 223 20 assistance assistance NN cord-021894-lq8yr710 223 21 with with IN cord-021894-lq8yr710 223 22 feeding feeding NN cord-021894-lq8yr710 223 23 by by IN cord-021894-lq8yr710 223 24 enteral enteral NN cord-021894-lq8yr710 223 25 or or CC cord-021894-lq8yr710 223 26 parenteral parenteral JJ cord-021894-lq8yr710 223 27 means mean NNS cord-021894-lq8yr710 223 28 . . . cord-021894-lq8yr710 224 1 The the DT cord-021894-lq8yr710 224 2 threshold threshold NN cord-021894-lq8yr710 224 3 for for IN cord-021894-lq8yr710 224 4 supporting support VBG cord-021894-lq8yr710 224 5 hydration hydration NN cord-021894-lq8yr710 224 6 is be VBZ cord-021894-lq8yr710 224 7 typically typically RB cord-021894-lq8yr710 224 8 when when WRB cord-021894-lq8yr710 224 9 an an DT cord-021894-lq8yr710 224 10 infant infant NN cord-021894-lq8yr710 224 11 's 's POS cord-021894-lq8yr710 224 12 intake intake NN cord-021894-lq8yr710 224 13 is be VBZ cord-021894-lq8yr710 224 14 reduced reduce VBN cord-021894-lq8yr710 224 15 to to IN cord-021894-lq8yr710 224 16 50 50 CD cord-021894-lq8yr710 224 17 % % NN cord-021894-lq8yr710 224 18 to to TO cord-021894-lq8yr710 224 19 75 75 CD cord-021894-lq8yr710 224 20 % % NN cord-021894-lq8yr710 224 21 of of IN cord-021894-lq8yr710 224 22 usual usual JJ cord-021894-lq8yr710 224 23 volume volume NN cord-021894-lq8yr710 224 24 . . . cord-021894-lq8yr710 225 1 The the DT cord-021894-lq8yr710 225 2 chosen choose VBN cord-021894-lq8yr710 225 3 percentage percentage NN cord-021894-lq8yr710 225 4 of of IN cord-021894-lq8yr710 225 5 intake intake NN cord-021894-lq8yr710 225 6 depends depend VBZ cord-021894-lq8yr710 225 7 on on IN cord-021894-lq8yr710 225 8 the the DT cord-021894-lq8yr710 225 9 child child NN cord-021894-lq8yr710 225 10 's 's POS cord-021894-lq8yr710 225 11 status status NN cord-021894-lq8yr710 225 12 : : : cord-021894-lq8yr710 225 13 an an DT cord-021894-lq8yr710 225 14 expreterm expreterm NN cord-021894-lq8yr710 225 15 10-week 10-week JJ cord-021894-lq8yr710 225 16 - - HYPH cord-021894-lq8yr710 225 17 old old JJ cord-021894-lq8yr710 225 18 infant infant NN cord-021894-lq8yr710 225 19 on on IN cord-021894-lq8yr710 225 20 day day NN cord-021894-lq8yr710 225 21 3 3 CD cord-021894-lq8yr710 225 22 of of IN cord-021894-lq8yr710 225 23 illness illness NN cord-021894-lq8yr710 225 24 may may MD cord-021894-lq8yr710 225 25 be be VB cord-021894-lq8yr710 225 26 supported support VBN cord-021894-lq8yr710 225 27 at at IN cord-021894-lq8yr710 225 28 75 75 CD cord-021894-lq8yr710 225 29 % % NN cord-021894-lq8yr710 225 30 understanding understanding NN cord-021894-lq8yr710 225 31 that that IN cord-021894-lq8yr710 225 32 they -PRON- PRP cord-021894-lq8yr710 225 33 most most RBS cord-021894-lq8yr710 225 34 likely likely RB cord-021894-lq8yr710 225 35 will will MD cord-021894-lq8yr710 225 36 deteriorate deteriorate VB cord-021894-lq8yr710 225 37 , , , cord-021894-lq8yr710 225 38 whereas whereas IN cord-021894-lq8yr710 225 39 a a DT cord-021894-lq8yr710 225 40 robust robust JJ cord-021894-lq8yr710 225 41 8-month 8-month JJ cord-021894-lq8yr710 225 42 - - HYPH cord-021894-lq8yr710 225 43 old old JJ cord-021894-lq8yr710 225 44 term term NN cord-021894-lq8yr710 225 45 infant infant NN cord-021894-lq8yr710 225 46 may may MD cord-021894-lq8yr710 225 47 be be VB cord-021894-lq8yr710 225 48 able able JJ cord-021894-lq8yr710 225 49 to to TO cord-021894-lq8yr710 225 50 tolerate tolerate VB cord-021894-lq8yr710 225 51 50 50 CD cord-021894-lq8yr710 225 52 % % NN cord-021894-lq8yr710 225 53 feed feed NN cord-021894-lq8yr710 225 54 volume volume NN cord-021894-lq8yr710 225 55 for for IN cord-021894-lq8yr710 225 56 a a DT cord-021894-lq8yr710 225 57 couple couple NN cord-021894-lq8yr710 225 58 of of IN cord-021894-lq8yr710 225 59 days day NNS cord-021894-lq8yr710 225 60 until until IN cord-021894-lq8yr710 225 61 disease disease NN cord-021894-lq8yr710 225 62 resolution resolution NN cord-021894-lq8yr710 225 63 . . . cord-021894-lq8yr710 226 1 Nasogastric nasogastric NN cord-021894-lq8yr710 226 2 feeding feeding NN cord-021894-lq8yr710 226 3 is be VBZ cord-021894-lq8yr710 226 4 easier easy JJR cord-021894-lq8yr710 226 5 to to TO cord-021894-lq8yr710 226 6 administer administer VB cord-021894-lq8yr710 226 7 than than IN cord-021894-lq8yr710 226 8 intravenous intravenous JJ cord-021894-lq8yr710 226 9 fluids fluid NNS cord-021894-lq8yr710 226 10 but but CC cord-021894-lq8yr710 226 11 has have VBZ cord-021894-lq8yr710 226 12 no no DT cord-021894-lq8yr710 226 13 advantage advantage NN cord-021894-lq8yr710 226 14 in in IN cord-021894-lq8yr710 226 15 recovery recovery NN cord-021894-lq8yr710 226 16 from from IN cord-021894-lq8yr710 226 17 acute acute JJ cord-021894-lq8yr710 226 18 disease disease NN cord-021894-lq8yr710 226 19 . . . cord-021894-lq8yr710 227 1 83 83 CD cord-021894-lq8yr710 227 2 Oxygen oxygen NN cord-021894-lq8yr710 227 3 may may MD cord-021894-lq8yr710 227 4 be be VB cord-021894-lq8yr710 227 5 used use VBN cord-021894-lq8yr710 227 6 to to TO cord-021894-lq8yr710 227 7 treat treat VB cord-021894-lq8yr710 227 8 hypoxemia hypoxemia NN cord-021894-lq8yr710 227 9 . . . cord-021894-lq8yr710 228 1 The the DT cord-021894-lq8yr710 228 2 threshold threshold NN cord-021894-lq8yr710 228 3 oxygen oxygen NN cord-021894-lq8yr710 228 4 saturation saturation NN cord-021894-lq8yr710 228 5 at at IN cord-021894-lq8yr710 228 6 which which WDT cord-021894-lq8yr710 228 7 to to TO cord-021894-lq8yr710 228 8 use use VB cord-021894-lq8yr710 228 9 supplemental supplemental JJ cord-021894-lq8yr710 228 10 oxygen oxygen NN cord-021894-lq8yr710 228 11 varies vary VBZ cord-021894-lq8yr710 228 12 across across IN cord-021894-lq8yr710 228 13 guidelines guideline NNS cord-021894-lq8yr710 228 14 and and CC cord-021894-lq8yr710 228 15 is be VBZ cord-021894-lq8yr710 228 16 typically typically RB cord-021894-lq8yr710 228 17 set set VBN cord-021894-lq8yr710 228 18 between between IN cord-021894-lq8yr710 228 19 90 90 CD cord-021894-lq8yr710 228 20 % % NN cord-021894-lq8yr710 228 21 and and CC cord-021894-lq8yr710 228 22 94 94 CD cord-021894-lq8yr710 228 23 % % NN cord-021894-lq8yr710 228 24 at at IN cord-021894-lq8yr710 228 25 sea sea NN cord-021894-lq8yr710 228 26 level level NN cord-021894-lq8yr710 228 27 . . . cord-021894-lq8yr710 229 1 In in IN cord-021894-lq8yr710 229 2 children child NNS cord-021894-lq8yr710 229 3 admitted admit VBN cord-021894-lq8yr710 229 4 to to IN cord-021894-lq8yr710 229 5 hospital hospital NN cord-021894-lq8yr710 229 6 with with IN cord-021894-lq8yr710 229 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 229 8 , , , cord-021894-lq8yr710 229 9 management management NN cord-021894-lq8yr710 229 10 at at IN cord-021894-lq8yr710 229 11 a a DT cord-021894-lq8yr710 229 12 threshold threshold NN cord-021894-lq8yr710 229 13 of of IN cord-021894-lq8yr710 229 14 90 90 CD cord-021894-lq8yr710 229 15 % % NN cord-021894-lq8yr710 229 16 SpO spo JJ cord-021894-lq8yr710 229 17 2 2 CD cord-021894-lq8yr710 229 18 is be VBZ cord-021894-lq8yr710 229 19 safe safe JJ cord-021894-lq8yr710 229 20 and and CC cord-021894-lq8yr710 229 21 as as RB cord-021894-lq8yr710 229 22 clinically clinically RB cord-021894-lq8yr710 229 23 effective effective JJ cord-021894-lq8yr710 229 24 as as IN cord-021894-lq8yr710 229 25 a a DT cord-021894-lq8yr710 229 26 94 94 CD cord-021894-lq8yr710 229 27 % % NN cord-021894-lq8yr710 229 28 target target NN cord-021894-lq8yr710 229 29 . . . cord-021894-lq8yr710 230 1 84 84 CD cord-021894-lq8yr710 231 1 The the DT cord-021894-lq8yr710 231 2 threshold threshold NN cord-021894-lq8yr710 231 3 oxygen oxygen NN cord-021894-lq8yr710 231 4 saturation saturation NN cord-021894-lq8yr710 231 5 for for IN cord-021894-lq8yr710 231 6 admission admission NN cord-021894-lq8yr710 231 7 to to IN cord-021894-lq8yr710 231 8 hospital hospital NN cord-021894-lq8yr710 231 9 is be VBZ cord-021894-lq8yr710 231 10 often often RB cord-021894-lq8yr710 231 11 92 92 CD cord-021894-lq8yr710 231 12 % % NN cord-021894-lq8yr710 231 13 , , , cord-021894-lq8yr710 231 14 as as IN cord-021894-lq8yr710 231 15 some some DT cord-021894-lq8yr710 231 16 data datum NNS cord-021894-lq8yr710 231 17 suggest suggest VBP cord-021894-lq8yr710 231 18 that that IN cord-021894-lq8yr710 231 19 infants infant NNS cord-021894-lq8yr710 231 20 have have VBP cord-021894-lq8yr710 231 21 a a DT cord-021894-lq8yr710 231 22 higher high JJR cord-021894-lq8yr710 231 23 risk risk NN cord-021894-lq8yr710 231 24 of of IN cord-021894-lq8yr710 231 25 desaturating desaturate VBG cord-021894-lq8yr710 231 26 further far RBR cord-021894-lq8yr710 231 27 at at IN cord-021894-lq8yr710 231 28 this this DT cord-021894-lq8yr710 231 29 oxygen oxygen NN cord-021894-lq8yr710 231 30 saturation saturation NN cord-021894-lq8yr710 231 31 . . . cord-021894-lq8yr710 232 1 85 85 CD cord-021894-lq8yr710 232 2 Oxygen oxygen NN cord-021894-lq8yr710 232 3 desaturation desaturation NN cord-021894-lq8yr710 232 4 may may MD cord-021894-lq8yr710 232 5 however however RB cord-021894-lq8yr710 232 6 have have VB cord-021894-lq8yr710 232 7 a a DT cord-021894-lq8yr710 232 8 disproportionate disproportionate JJ cord-021894-lq8yr710 232 9 influence influence NN cord-021894-lq8yr710 232 10 on on IN cord-021894-lq8yr710 232 11 decisions decision NNS cord-021894-lq8yr710 232 12 to to TO cord-021894-lq8yr710 232 13 admit admit VB cord-021894-lq8yr710 232 14 children child NNS cord-021894-lq8yr710 232 15 to to IN cord-021894-lq8yr710 232 16 the the DT cord-021894-lq8yr710 232 17 hospital hospital NN cord-021894-lq8yr710 232 18 , , , cord-021894-lq8yr710 232 19 68 68 CD cord-021894-lq8yr710 232 20 and and CC cord-021894-lq8yr710 232 21 much much JJ cord-021894-lq8yr710 232 22 like like IN cord-021894-lq8yr710 232 23 hydration hydration NN cord-021894-lq8yr710 232 24 status status NN cord-021894-lq8yr710 232 25 ( ( -LRB- cord-021894-lq8yr710 232 26 previously previously RB cord-021894-lq8yr710 232 27 mentioned mention VBN cord-021894-lq8yr710 232 28 ) ) -RRB- cord-021894-lq8yr710 232 29 , , , cord-021894-lq8yr710 232 30 the the DT cord-021894-lq8yr710 232 31 context context NN cord-021894-lq8yr710 232 32 of of IN cord-021894-lq8yr710 232 33 the the DT cord-021894-lq8yr710 232 34 measurement measurement NN cord-021894-lq8yr710 232 35 should should MD cord-021894-lq8yr710 232 36 be be VB cord-021894-lq8yr710 232 37 considered consider VBN cord-021894-lq8yr710 232 38 . . . cord-021894-lq8yr710 233 1 Many many JJ cord-021894-lq8yr710 233 2 infants infant NNS cord-021894-lq8yr710 233 3 discharged discharge VBD cord-021894-lq8yr710 233 4 home home RB cord-021894-lq8yr710 233 5 from from IN cord-021894-lq8yr710 233 6 ED ED NNP cord-021894-lq8yr710 233 7 with with IN cord-021894-lq8yr710 233 8 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 233 9 experience experience NN cord-021894-lq8yr710 234 1 desaturation desaturation NN cord-021894-lq8yr710 234 2 events event NNS cord-021894-lq8yr710 234 3 subsequently subsequently RB cord-021894-lq8yr710 234 4 that that WDT cord-021894-lq8yr710 234 5 are be VBP cord-021894-lq8yr710 234 6 not not RB cord-021894-lq8yr710 234 7 associated associate VBN cord-021894-lq8yr710 234 8 with with IN cord-021894-lq8yr710 234 9 clinical clinical JJ cord-021894-lq8yr710 234 10 deterioration deterioration NN cord-021894-lq8yr710 234 11 . . . cord-021894-lq8yr710 235 1 67 67 CD cord-021894-lq8yr710 236 1 In in IN cord-021894-lq8yr710 236 2 hospitals hospital NNS cord-021894-lq8yr710 236 3 , , , cord-021894-lq8yr710 236 4 the the DT cord-021894-lq8yr710 236 5 use use NN cord-021894-lq8yr710 236 6 of of IN cord-021894-lq8yr710 236 7 intermittent intermittent JJ cord-021894-lq8yr710 236 8 oxygen oxygen NN cord-021894-lq8yr710 236 9 saturation saturation NN cord-021894-lq8yr710 236 10 monitoring monitoring NN cord-021894-lq8yr710 236 11 is be VBZ cord-021894-lq8yr710 236 12 much much RB cord-021894-lq8yr710 236 13 discussed discuss VBN cord-021894-lq8yr710 236 14 , , , cord-021894-lq8yr710 236 15 and and CC cord-021894-lq8yr710 236 16 though though IN cord-021894-lq8yr710 236 17 the the DT cord-021894-lq8yr710 236 18 benefit benefit NN cord-021894-lq8yr710 236 19 below below IN cord-021894-lq8yr710 236 20 90 90 CD cord-021894-lq8yr710 236 21 % % NN cord-021894-lq8yr710 236 22 SpO spo JJ cord-021894-lq8yr710 236 23 2 2 CD cord-021894-lq8yr710 236 24 is be VBZ cord-021894-lq8yr710 236 25 not not RB cord-021894-lq8yr710 236 26 established establish VBN cord-021894-lq8yr710 236 27 , , , cord-021894-lq8yr710 236 28 once once RB cord-021894-lq8yr710 236 29 stable stable JJ cord-021894-lq8yr710 236 30 above above IN cord-021894-lq8yr710 236 31 90 90 CD cord-021894-lq8yr710 236 32 % % NN cord-021894-lq8yr710 236 33 SpO spo JJ cord-021894-lq8yr710 236 34 2 2 CD cord-021894-lq8yr710 236 35 , , , cord-021894-lq8yr710 236 36 oxygen oxygen NN cord-021894-lq8yr710 236 37 saturation saturation NN cord-021894-lq8yr710 236 38 monitoring monitoring NN cord-021894-lq8yr710 236 39 should should MD cord-021894-lq8yr710 236 40 be be VB cord-021894-lq8yr710 236 41 stopped stop VBN cord-021894-lq8yr710 236 42 . . . cord-021894-lq8yr710 237 1 86 86 CD cord-021894-lq8yr710 237 2 Use use NN cord-021894-lq8yr710 237 3 of of IN cord-021894-lq8yr710 237 4 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 237 5 occurs occur VBZ cord-021894-lq8yr710 237 6 in in IN cord-021894-lq8yr710 237 7 62 62 CD cord-021894-lq8yr710 237 8 % % NN cord-021894-lq8yr710 237 9 of of IN cord-021894-lq8yr710 237 10 those those DT cord-021894-lq8yr710 237 11 who who WP cord-021894-lq8yr710 237 12 are be VBP cord-021894-lq8yr710 237 13 RSV RSV NNP cord-021894-lq8yr710 237 14 positive positive JJ cord-021894-lq8yr710 237 15 and and CC cord-021894-lq8yr710 237 16 32 32 CD cord-021894-lq8yr710 237 17 % % NN cord-021894-lq8yr710 237 18 of of IN cord-021894-lq8yr710 237 19 those those DT cord-021894-lq8yr710 237 20 who who WP cord-021894-lq8yr710 237 21 are be VBP cord-021894-lq8yr710 237 22 RSV RSV NNP cord-021894-lq8yr710 237 23 negative negative JJ cord-021894-lq8yr710 237 24 . . . cord-021894-lq8yr710 238 1 120 120 CD cord-021894-lq8yr710 239 1 Recurrent recurrent JJ cord-021894-lq8yr710 239 2 postinfectious postinfectious JJ cord-021894-lq8yr710 239 3 wheeze wheeze NN cord-021894-lq8yr710 239 4 is be VBZ cord-021894-lq8yr710 239 5 not not RB cord-021894-lq8yr710 239 6 reduced reduce VBN cord-021894-lq8yr710 239 7 by by IN cord-021894-lq8yr710 239 8 montelukast montelukast NN cord-021894-lq8yr710 239 9 121 121 CD cord-021894-lq8yr710 239 10 or or CC cord-021894-lq8yr710 239 11 inhaled inhale VBN cord-021894-lq8yr710 239 12 corticosteroids corticosteroid NNS cord-021894-lq8yr710 239 13 , , , cord-021894-lq8yr710 239 14 122 122 CD cord-021894-lq8yr710 239 15 , , , cord-021894-lq8yr710 239 16 123 123 CD cord-021894-lq8yr710 239 17 but but CC cord-021894-lq8yr710 239 18 there there EX cord-021894-lq8yr710 239 19 is be VBZ cord-021894-lq8yr710 239 20 good good JJ cord-021894-lq8yr710 239 21 evidence evidence NN cord-021894-lq8yr710 239 22 of of IN cord-021894-lq8yr710 239 23 benefit benefit NN cord-021894-lq8yr710 239 24 from from IN cord-021894-lq8yr710 239 25 Palivizumab Palivizumab NNP cord-021894-lq8yr710 239 26 , , , cord-021894-lq8yr710 239 27 124 124 CD cord-021894-lq8yr710 239 28 and and CC cord-021894-lq8yr710 239 29 potentially potentially RB cord-021894-lq8yr710 239 30 azithromycin azithromycin NN cord-021894-lq8yr710 239 31 , , , cord-021894-lq8yr710 239 32 125 125 CD cord-021894-lq8yr710 239 33 though though IN cord-021894-lq8yr710 239 34 the the DT cord-021894-lq8yr710 239 35 latter latter NN cord-021894-lq8yr710 239 36 requires require VBZ cord-021894-lq8yr710 239 37 further further JJ cord-021894-lq8yr710 239 38 study study NN cord-021894-lq8yr710 239 39 . . . cord-021894-lq8yr710 240 1 In in IN cord-021894-lq8yr710 240 2 the the DT cord-021894-lq8yr710 240 3 longer long JJR cord-021894-lq8yr710 240 4 term term NN cord-021894-lq8yr710 240 5 , , , cord-021894-lq8yr710 240 6 there there EX cord-021894-lq8yr710 240 7 is be VBZ cord-021894-lq8yr710 240 8 good good JJ cord-021894-lq8yr710 240 9 evidence evidence NN cord-021894-lq8yr710 240 10 that that IN cord-021894-lq8yr710 240 11 children child NNS cord-021894-lq8yr710 240 12 who who WP cord-021894-lq8yr710 240 13 have have VBP cord-021894-lq8yr710 240 14 had have VBN cord-021894-lq8yr710 240 15 an an DT cord-021894-lq8yr710 240 16 admission admission NN cord-021894-lq8yr710 240 17 to to IN cord-021894-lq8yr710 240 18 the the DT cord-021894-lq8yr710 240 19 hospital hospital NN cord-021894-lq8yr710 240 20 for for IN cord-021894-lq8yr710 240 21 RSV RSV NNP cord-021894-lq8yr710 240 22 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 240 23 are be VBP cord-021894-lq8yr710 240 24 3 3 CD cord-021894-lq8yr710 240 25 times time NNS cord-021894-lq8yr710 240 26 more more RBR cord-021894-lq8yr710 240 27 likely likely JJ cord-021894-lq8yr710 240 28 to to TO cord-021894-lq8yr710 240 29 have have VB cord-021894-lq8yr710 240 30 a a DT cord-021894-lq8yr710 240 31 diagnosis diagnosis NN cord-021894-lq8yr710 240 32 of of IN cord-021894-lq8yr710 240 33 asthma asthma NN cord-021894-lq8yr710 240 34 and and CC cord-021894-lq8yr710 240 35 lower low JJR cord-021894-lq8yr710 240 36 lung lung NN cord-021894-lq8yr710 240 37 function function NN cord-021894-lq8yr710 240 38 at at IN cord-021894-lq8yr710 240 39 age age NN cord-021894-lq8yr710 240 40 6 6 CD cord-021894-lq8yr710 240 41 years year NNS cord-021894-lq8yr710 240 42 23 23 CD cord-021894-lq8yr710 240 43 and and CC cord-021894-lq8yr710 240 44 a a DT cord-021894-lq8yr710 240 45 higher high JJR cord-021894-lq8yr710 240 46 incidence incidence NN cord-021894-lq8yr710 240 47 of of IN cord-021894-lq8yr710 240 48 asthma asthma NN cord-021894-lq8yr710 240 49 at at IN cord-021894-lq8yr710 240 50 age age NN cord-021894-lq8yr710 240 51 13 13 CD cord-021894-lq8yr710 240 52 126 126 CD cord-021894-lq8yr710 240 53 and and CC cord-021894-lq8yr710 240 54 18 18 CD cord-021894-lq8yr710 240 55 127 127 CD cord-021894-lq8yr710 240 56 years year NNS cord-021894-lq8yr710 240 57 . . . cord-021894-lq8yr710 241 1 The the DT cord-021894-lq8yr710 241 2 question question NN cord-021894-lq8yr710 241 3 remains remain VBZ cord-021894-lq8yr710 241 4 whether whether IN cord-021894-lq8yr710 241 5 such such JJ cord-021894-lq8yr710 241 6 children child NNS cord-021894-lq8yr710 241 7 are be VBP cord-021894-lq8yr710 241 8 predisposed predisposed JJ cord-021894-lq8yr710 241 9 to to TO cord-021894-lq8yr710 241 10 bronchiolitis bronchiolitis VB cord-021894-lq8yr710 241 11 because because IN cord-021894-lq8yr710 241 12 of of IN cord-021894-lq8yr710 241 13 premorbid premorbid NN cord-021894-lq8yr710 241 14 anatomy anatomy NNP cord-021894-lq8yr710 241 15 119 119 CD cord-021894-lq8yr710 241 16 and and CC cord-021894-lq8yr710 241 17 the the DT cord-021894-lq8yr710 241 18 consequent consequent JJ cord-021894-lq8yr710 241 19 interrelationship interrelationship NN cord-021894-lq8yr710 241 20 between between IN cord-021894-lq8yr710 241 21 host host NN cord-021894-lq8yr710 241 22 and and CC cord-021894-lq8yr710 241 23 virus virus NN cord-021894-lq8yr710 241 24 specific specific JJ cord-021894-lq8yr710 241 25 effects effect NNS cord-021894-lq8yr710 241 26 on on IN cord-021894-lq8yr710 241 27 the the DT cord-021894-lq8yr710 241 28 development development NN cord-021894-lq8yr710 241 29 of of IN cord-021894-lq8yr710 241 30 asthma asthma NN cord-021894-lq8yr710 241 31 . . . cord-021894-lq8yr710 242 1 vaccines vaccine NNS cord-021894-lq8yr710 242 2 were be VBD cord-021894-lq8yr710 242 3 associated associate VBN cord-021894-lq8yr710 242 4 with with IN cord-021894-lq8yr710 242 5 more more RBR cord-021894-lq8yr710 242 6 severe severe JJ cord-021894-lq8yr710 242 7 enhanced enhance VBN cord-021894-lq8yr710 242 8 RSV RSV NNP cord-021894-lq8yr710 242 9 disease disease NN cord-021894-lq8yr710 242 10 and and CC cord-021894-lq8yr710 242 11 deaths death NNS cord-021894-lq8yr710 242 12 , , , cord-021894-lq8yr710 242 13 possibly possibly RB cord-021894-lq8yr710 242 14 resulting result VBG cord-021894-lq8yr710 242 15 from from IN cord-021894-lq8yr710 242 16 inadequate inadequate JJ cord-021894-lq8yr710 242 17 T t NN cord-021894-lq8yr710 242 18 cell cell NN cord-021894-lq8yr710 242 19 priming priming NN cord-021894-lq8yr710 242 20 . . . cord-021894-lq8yr710 243 1 113 113 CD cord-021894-lq8yr710 244 1 Subsequent subsequent JJ cord-021894-lq8yr710 244 2 vaccine vaccine NN cord-021894-lq8yr710 244 3 development development NN cord-021894-lq8yr710 244 4 has have VBZ cord-021894-lq8yr710 244 5 been be VBN cord-021894-lq8yr710 244 6 cautious cautious JJ cord-021894-lq8yr710 244 7 in in IN cord-021894-lq8yr710 244 8 view view NN cord-021894-lq8yr710 244 9 of of IN cord-021894-lq8yr710 244 10 this this DT cord-021894-lq8yr710 244 11 experience experience NN cord-021894-lq8yr710 244 12 . . . cord-021894-lq8yr710 245 1 In in IN cord-021894-lq8yr710 245 2 the the DT cord-021894-lq8yr710 245 3 1990s 1990 NNS cord-021894-lq8yr710 245 4 , , , cord-021894-lq8yr710 245 5 RSV RSV NNP cord-021894-lq8yr710 245 6 intravenous intravenous JJ cord-021894-lq8yr710 245 7 immunoglobulin immunoglobulin NN cord-021894-lq8yr710 245 8 was be VBD cord-021894-lq8yr710 245 9 developed develop VBN cord-021894-lq8yr710 245 10 114 114 CD cord-021894-lq8yr710 245 11 , , , cord-021894-lq8yr710 245 12 115 115 CD cord-021894-lq8yr710 245 13 but but CC cord-021894-lq8yr710 245 14 was be VBD cord-021894-lq8yr710 245 15 rapidly rapidly RB cord-021894-lq8yr710 245 16 superseded supersede VBN cord-021894-lq8yr710 245 17 by by IN cord-021894-lq8yr710 245 18 palivizumab palivizumab NNP cord-021894-lq8yr710 245 19 , , , cord-021894-lq8yr710 245 20 a a DT cord-021894-lq8yr710 245 21 monoclonal monoclonal JJ cord-021894-lq8yr710 245 22 antibody antibody NN cord-021894-lq8yr710 245 23 delivered deliver VBN cord-021894-lq8yr710 245 24 by by IN cord-021894-lq8yr710 245 25 monthly monthly JJ cord-021894-lq8yr710 245 26 intramuscular intramuscular JJ cord-021894-lq8yr710 245 27 injection injection NN cord-021894-lq8yr710 245 28 . . . cord-021894-lq8yr710 246 1 When when WRB cord-021894-lq8yr710 246 2 administered administer VBN cord-021894-lq8yr710 246 3 over over IN cord-021894-lq8yr710 246 4 the the DT cord-021894-lq8yr710 246 5 RSV RSV NNP cord-021894-lq8yr710 246 6 season season NN cord-021894-lq8yr710 246 7 , , , cord-021894-lq8yr710 246 8 it -PRON- PRP cord-021894-lq8yr710 246 9 reduces reduce VBZ cord-021894-lq8yr710 246 10 hospital hospital NN cord-021894-lq8yr710 246 11 admission admission NN cord-021894-lq8yr710 246 12 in in IN cord-021894-lq8yr710 246 13 high high JJ cord-021894-lq8yr710 246 14 - - HYPH cord-021894-lq8yr710 246 15 risk risk NN cord-021894-lq8yr710 246 16 infants infant NNS cord-021894-lq8yr710 246 17 . . . cord-021894-lq8yr710 247 1 116 116 CD cord-021894-lq8yr710 247 2 Palivizumab Palivizumab NNP cord-021894-lq8yr710 247 3 's 's POS cord-021894-lq8yr710 247 4 monthly monthly JJ cord-021894-lq8yr710 247 5 injections injection NNS cord-021894-lq8yr710 247 6 and and CC cord-021894-lq8yr710 247 7 limited limited JJ cord-021894-lq8yr710 247 8 efficacy efficacy NN cord-021894-lq8yr710 247 9 have have VBP cord-021894-lq8yr710 247 10 prompted prompt VBN cord-021894-lq8yr710 247 11 the the DT cord-021894-lq8yr710 247 12 development development NN cord-021894-lq8yr710 247 13 of of IN cord-021894-lq8yr710 247 14 extended extended JJ cord-021894-lq8yr710 247 15 life life NN cord-021894-lq8yr710 247 16 monoclonal monoclonal JJ cord-021894-lq8yr710 247 17 antibodies antibody NNS cord-021894-lq8yr710 247 18 that that WDT cord-021894-lq8yr710 247 19 are be VBP cord-021894-lq8yr710 247 20 undergoing undergo VBG cord-021894-lq8yr710 247 21 licensing license VBG cord-021894-lq8yr710 247 22 trials trial NNS cord-021894-lq8yr710 247 23 in in IN cord-021894-lq8yr710 247 24 preterm preterm JJ cord-021894-lq8yr710 247 25 infants infant NNS cord-021894-lq8yr710 247 26 . . . cord-021894-lq8yr710 248 1 117 117 CD cord-021894-lq8yr710 249 1 They -PRON- PRP cord-021894-lq8yr710 249 2 will will MD cord-021894-lq8yr710 249 3 hopefully hopefully RB cord-021894-lq8yr710 249 4 be be VB cord-021894-lq8yr710 249 5 evaluated evaluate VBN cord-021894-lq8yr710 249 6 in in IN cord-021894-lq8yr710 249 7 the the DT cord-021894-lq8yr710 249 8 future future NN cord-021894-lq8yr710 249 9 for for IN cord-021894-lq8yr710 249 10 high high JJ cord-021894-lq8yr710 249 11 - - HYPH cord-021894-lq8yr710 249 12 risk risk NN cord-021894-lq8yr710 249 13 infants infant NNS cord-021894-lq8yr710 249 14 born bear VBN cord-021894-lq8yr710 249 15 at at IN cord-021894-lq8yr710 249 16 term term NN cord-021894-lq8yr710 249 17 . . . cord-021894-lq8yr710 250 1 RSV RSV NNP cord-021894-lq8yr710 250 2 vaccine vaccine NN cord-021894-lq8yr710 250 3 development development NN cord-021894-lq8yr710 250 4 has have VBZ cord-021894-lq8yr710 250 5 gained gain VBN cord-021894-lq8yr710 250 6 significant significant JJ cord-021894-lq8yr710 250 7 impetus impetus NN cord-021894-lq8yr710 250 8 over over IN cord-021894-lq8yr710 250 9 the the DT cord-021894-lq8yr710 250 10 last last JJ cord-021894-lq8yr710 250 11 15 15 CD cord-021894-lq8yr710 250 12 years year NNS cord-021894-lq8yr710 250 13 with with IN cord-021894-lq8yr710 250 14 a a DT cord-021894-lq8yr710 250 15 wide wide JJ cord-021894-lq8yr710 250 16 range range NN cord-021894-lq8yr710 250 17 of of IN cord-021894-lq8yr710 250 18 candidate candidate NN cord-021894-lq8yr710 250 19 vaccines vaccine NNS cord-021894-lq8yr710 250 20 in in IN cord-021894-lq8yr710 250 21 development development NN cord-021894-lq8yr710 250 22 both both DT cord-021894-lq8yr710 250 23 for for IN cord-021894-lq8yr710 250 24 pediatric pediatric JJ cord-021894-lq8yr710 250 25 and and CC cord-021894-lq8yr710 250 26 maternal maternal JJ cord-021894-lq8yr710 250 27 use use NN cord-021894-lq8yr710 250 28 ; ; , cord-021894-lq8yr710 250 29 maternal maternal JJ cord-021894-lq8yr710 250 30 immunization immunization NN cord-021894-lq8yr710 250 31 could could MD cord-021894-lq8yr710 250 32 provide provide VB cord-021894-lq8yr710 250 33 passive passive JJ cord-021894-lq8yr710 250 34 transplacental transplacental JJ cord-021894-lq8yr710 250 35 protection protection NN cord-021894-lq8yr710 250 36 to to IN cord-021894-lq8yr710 250 37 infants infant NNS cord-021894-lq8yr710 250 38 in in IN cord-021894-lq8yr710 250 39 the the DT cord-021894-lq8yr710 250 40 first first JJ cord-021894-lq8yr710 250 41 3 3 CD cord-021894-lq8yr710 250 42 to to TO cord-021894-lq8yr710 250 43 6 6 CD cord-021894-lq8yr710 250 44 months month NNS cord-021894-lq8yr710 250 45 of of IN cord-021894-lq8yr710 250 46 life life NN cord-021894-lq8yr710 250 47 ( ( -LRB- cord-021894-lq8yr710 250 48 http:// http:// NNP cord-021894-lq8yr710 250 49 www.path.org www.path.org NNP cord-021894-lq8yr710 250 50 ) ) -RRB- cord-021894-lq8yr710 250 51 . . . cord-021894-lq8yr710 251 1 A a DT cord-021894-lq8yr710 251 2 Phase Phase NNP cord-021894-lq8yr710 251 3 III III NNP cord-021894-lq8yr710 251 4 trial trial NN cord-021894-lq8yr710 251 5 of of IN cord-021894-lq8yr710 251 6 maternal maternal JJ cord-021894-lq8yr710 251 7 immunization immunization NN cord-021894-lq8yr710 251 8 by by IN cord-021894-lq8yr710 251 9 Novovax Novovax NNP cord-021894-lq8yr710 251 10 is be VBZ cord-021894-lq8yr710 251 11 expected expect VBN cord-021894-lq8yr710 251 12 to to TO cord-021894-lq8yr710 251 13 conclude conclude VB cord-021894-lq8yr710 251 14 in in IN cord-021894-lq8yr710 251 15 2020 2020 CD cord-021894-lq8yr710 251 16 . . . cord-021894-lq8yr710 252 1 For for IN cord-021894-lq8yr710 252 2 most most JJS cord-021894-lq8yr710 252 3 children child NNS cord-021894-lq8yr710 252 4 , , , cord-021894-lq8yr710 252 5 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 252 6 is be VBZ cord-021894-lq8yr710 252 7 a a DT cord-021894-lq8yr710 252 8 self self NN cord-021894-lq8yr710 252 9 - - HYPH cord-021894-lq8yr710 252 10 limiting limit VBG cord-021894-lq8yr710 252 11 disease disease NN cord-021894-lq8yr710 252 12 , , , cord-021894-lq8yr710 252 13 with with IN cord-021894-lq8yr710 252 14 cough cough NN cord-021894-lq8yr710 252 15 as as IN cord-021894-lq8yr710 252 16 the the DT cord-021894-lq8yr710 252 17 most most RBS cord-021894-lq8yr710 252 18 persistent persistent JJ cord-021894-lq8yr710 252 19 symptom symptom NN cord-021894-lq8yr710 252 20 resolving resolve VBG cord-021894-lq8yr710 252 21 at at IN cord-021894-lq8yr710 252 22 a a DT cord-021894-lq8yr710 252 23 median median NN cord-021894-lq8yr710 252 24 of of IN cord-021894-lq8yr710 252 25 12 12 CD cord-021894-lq8yr710 252 26 to to TO cord-021894-lq8yr710 252 27 15 15 CD cord-021894-lq8yr710 252 28 days day NNS cord-021894-lq8yr710 252 29 . . . cord-021894-lq8yr710 253 1 84 84 CD cord-021894-lq8yr710 253 2 , , , cord-021894-lq8yr710 253 3 118 118 CD cord-021894-lq8yr710 253 4 Many many JJ cord-021894-lq8yr710 253 5 children child NNS cord-021894-lq8yr710 253 6 , , , cord-021894-lq8yr710 253 7 however however RB cord-021894-lq8yr710 253 8 , , , cord-021894-lq8yr710 253 9 develop develop VB cord-021894-lq8yr710 253 10 recurrent recurrent JJ cord-021894-lq8yr710 253 11 respiratory respiratory JJ cord-021894-lq8yr710 253 12 symptoms symptom NNS cord-021894-lq8yr710 253 13 . . . cord-021894-lq8yr710 254 1 In in IN cord-021894-lq8yr710 254 2 the the DT cord-021894-lq8yr710 254 3 first first JJ cord-021894-lq8yr710 254 4 few few JJ cord-021894-lq8yr710 254 5 months month NNS cord-021894-lq8yr710 254 6 following follow VBG cord-021894-lq8yr710 254 7 illness illness NN cord-021894-lq8yr710 254 8 , , , cord-021894-lq8yr710 254 9 this this DT cord-021894-lq8yr710 254 10 is be VBZ cord-021894-lq8yr710 254 11 considered consider VBN cord-021894-lq8yr710 254 12 in in IN cord-021894-lq8yr710 254 13 part part NN cord-021894-lq8yr710 254 14 to to TO cord-021894-lq8yr710 254 15 result result VB cord-021894-lq8yr710 254 16 from from IN cord-021894-lq8yr710 254 17 loss loss NN cord-021894-lq8yr710 254 18 of of IN cord-021894-lq8yr710 254 19 cilia cilia NN cord-021894-lq8yr710 254 20 from from IN cord-021894-lq8yr710 254 21 the the DT cord-021894-lq8yr710 254 22 airway airway NN cord-021894-lq8yr710 254 23 epithelial epithelial JJ cord-021894-lq8yr710 254 24 surfaces surface NNS cord-021894-lq8yr710 254 25 during during IN cord-021894-lq8yr710 254 26 the the DT cord-021894-lq8yr710 254 27 acute acute JJ cord-021894-lq8yr710 254 28 illness illness NN cord-021894-lq8yr710 254 29 . . . cord-021894-lq8yr710 255 1 40 40 CD cord-021894-lq8yr710 256 1 For for IN cord-021894-lq8yr710 256 2 those those DT cord-021894-lq8yr710 256 3 who who WP cord-021894-lq8yr710 256 4 experience experience VBP cord-021894-lq8yr710 256 5 chronic chronic JJ cord-021894-lq8yr710 256 6 symptoms symptom NNS cord-021894-lq8yr710 256 7 , , , cord-021894-lq8yr710 256 8 the the DT cord-021894-lq8yr710 256 9 debate debate NN cord-021894-lq8yr710 256 10 continues continue VBZ cord-021894-lq8yr710 256 11 on on IN cord-021894-lq8yr710 256 12 whether whether IN cord-021894-lq8yr710 256 13 children child NNS cord-021894-lq8yr710 256 14 with with IN cord-021894-lq8yr710 256 15 more more RBR cord-021894-lq8yr710 256 16 severe severe JJ cord-021894-lq8yr710 256 17 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 256 18 and and CC cord-021894-lq8yr710 256 19 recurrent recurrent JJ cord-021894-lq8yr710 256 20 postinfectious postinfectious NNP cord-021894-lq8yr710 257 1 wheezing wheeze VBG cord-021894-lq8yr710 257 2 have have VBP cord-021894-lq8yr710 257 3 premorbid premorbid NN cord-021894-lq8yr710 257 4 susceptibility susceptibility NN cord-021894-lq8yr710 257 5 , , , cord-021894-lq8yr710 257 6 with with IN cord-021894-lq8yr710 257 7 some some DT cord-021894-lq8yr710 257 8 evidence evidence NN cord-021894-lq8yr710 257 9 suggesting suggest VBG cord-021894-lq8yr710 257 10 poorer poor JJR cord-021894-lq8yr710 257 11 preexisting preexisting JJ cord-021894-lq8yr710 257 12 lung lung NN cord-021894-lq8yr710 257 13 function function NN cord-021894-lq8yr710 257 14 . . . cord-021894-lq8yr710 258 1 119 119 CD cord-021894-lq8yr710 258 2 Recurrent recurrent JJ cord-021894-lq8yr710 258 3 wheeze wheeze NN cord-021894-lq8yr710 258 4 in in IN cord-021894-lq8yr710 258 5 the the DT cord-021894-lq8yr710 258 6 year year NN cord-021894-lq8yr710 258 7 following follow VBG cord-021894-lq8yr710 258 8 Oxygen oxygen NN cord-021894-lq8yr710 258 9 saturation saturation NN cord-021894-lq8yr710 258 10 targets target NNS cord-021894-lq8yr710 258 11 in in IN cord-021894-lq8yr710 258 12 infants infant NNS cord-021894-lq8yr710 258 13 with with IN cord-021894-lq8yr710 258 14 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 258 15 ( ( -LRB- cord-021894-lq8yr710 258 16 BIDS BIDS NNP cord-021894-lq8yr710 258 17 ) ) -RRB- cord-021894-lq8yr710 258 18 : : : cord-021894-lq8yr710 258 19 a a DT cord-021894-lq8yr710 258 20 double double JJ cord-021894-lq8yr710 258 21 - - HYPH cord-021894-lq8yr710 258 22 blind blind JJ cord-021894-lq8yr710 258 23 , , , cord-021894-lq8yr710 258 24 randomised randomised JJ cord-021894-lq8yr710 258 25 , , , cord-021894-lq8yr710 258 26 equivalence equivalence NN cord-021894-lq8yr710 258 27 trial trial NN cord-021894-lq8yr710 258 28 SABRE SABRE NNP cord-021894-lq8yr710 258 29 : : : cord-021894-lq8yr710 258 30 a a DT cord-021894-lq8yr710 258 31 multicentre multicentre NNP cord-021894-lq8yr710 258 32 randomised randomised JJ cord-021894-lq8yr710 258 33 control control NN cord-021894-lq8yr710 258 34 trial trial NN cord-021894-lq8yr710 258 35 of of IN cord-021894-lq8yr710 258 36 nebulised nebulised JJ cord-021894-lq8yr710 258 37 hypertonic hypertonic JJ cord-021894-lq8yr710 258 38 saline saline NN cord-021894-lq8yr710 258 39 in in IN cord-021894-lq8yr710 258 40 infants infant NNS cord-021894-lq8yr710 258 41 hospitalised hospitalise VBN cord-021894-lq8yr710 258 42 with with IN cord-021894-lq8yr710 258 43 acute acute JJ cord-021894-lq8yr710 258 44 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 258 45 Nebulized Nebulized NNP cord-021894-lq8yr710 258 46 hypertonic hypertonic JJ cord-021894-lq8yr710 258 47 saline saline NN cord-021894-lq8yr710 258 48 for for IN cord-021894-lq8yr710 258 49 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 258 50 in in IN cord-021894-lq8yr710 258 51 the the DT cord-021894-lq8yr710 258 52 emergency emergency NN cord-021894-lq8yr710 258 53 department department NN cord-021894-lq8yr710 258 54 : : : cord-021894-lq8yr710 258 55 a a DT cord-021894-lq8yr710 258 56 randomized randomized JJ cord-021894-lq8yr710 258 57 clinical clinical JJ cord-021894-lq8yr710 258 58 trial trial NN cord-021894-lq8yr710 258 59 7 7 CD cord-021894-lq8yr710 258 60 % % NN cord-021894-lq8yr710 258 61 Hypertonic Hypertonic NNP cord-021894-lq8yr710 258 62 saline saline NN cord-021894-lq8yr710 258 63 in in IN cord-021894-lq8yr710 258 64 acute acute JJ cord-021894-lq8yr710 258 65 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 258 66 : : : cord-021894-lq8yr710 258 67 a a DT cord-021894-lq8yr710 258 68 randomized randomized JJ cord-021894-lq8yr710 258 69 controlled control VBN cord-021894-lq8yr710 258 70 trial trial NN cord-021894-lq8yr710 258 71 3 3 CD cord-021894-lq8yr710 258 72 % % NN cord-021894-lq8yr710 258 73 hypertonic hypertonic JJ cord-021894-lq8yr710 258 74 saline saline NN cord-021894-lq8yr710 258 75 versus versus IN cord-021894-lq8yr710 258 76 normal normal JJ cord-021894-lq8yr710 258 77 saline saline NN cord-021894-lq8yr710 258 78 in in IN cord-021894-lq8yr710 258 79 inpatient inpatient JJ cord-021894-lq8yr710 258 80 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 258 81 : : : cord-021894-lq8yr710 258 82 a a DT cord-021894-lq8yr710 258 83 randomized randomized JJ cord-021894-lq8yr710 258 84 controlled control VBN cord-021894-lq8yr710 258 85 trial trial NN cord-021894-lq8yr710 259 1 The the DT cord-021894-lq8yr710 259 2 effect effect NN cord-021894-lq8yr710 259 3 of of IN cord-021894-lq8yr710 259 4 3 3 CD cord-021894-lq8yr710 259 5 % % NN cord-021894-lq8yr710 259 6 and and CC cord-021894-lq8yr710 259 7 6 6 CD cord-021894-lq8yr710 259 8 % % NN cord-021894-lq8yr710 259 9 hypertonic hypertonic JJ cord-021894-lq8yr710 259 10 saline saline NN cord-021894-lq8yr710 259 11 in in IN cord-021894-lq8yr710 259 12 viral viral JJ cord-021894-lq8yr710 259 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 259 14 : : : cord-021894-lq8yr710 259 15 a a DT cord-021894-lq8yr710 259 16 randomised randomised JJ cord-021894-lq8yr710 259 17 controlled control VBN cord-021894-lq8yr710 259 18 trial trial NN cord-021894-lq8yr710 259 19 Nebulized Nebulized NNP cord-021894-lq8yr710 259 20 hypertonic hypertonic JJ cord-021894-lq8yr710 259 21 saline saline NN cord-021894-lq8yr710 259 22 for for IN cord-021894-lq8yr710 259 23 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 259 24 : : : cord-021894-lq8yr710 259 25 a a DT cord-021894-lq8yr710 259 26 randomized randomized JJ cord-021894-lq8yr710 259 27 clinical clinical JJ cord-021894-lq8yr710 259 28 trial trial NN cord-021894-lq8yr710 259 29 Risk risk NN cord-021894-lq8yr710 259 30 factors factor NNS cord-021894-lq8yr710 259 31 for for IN cord-021894-lq8yr710 259 32 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 259 33 , , , cord-021894-lq8yr710 259 34 recurrent recurrent JJ cord-021894-lq8yr710 259 35 wheezing wheeze VBG cord-021894-lq8yr710 259 36 , , , cord-021894-lq8yr710 259 37 and and CC cord-021894-lq8yr710 259 38 related related JJ cord-021894-lq8yr710 259 39 hospitalization hospitalization NN cord-021894-lq8yr710 259 40 in in IN cord-021894-lq8yr710 259 41 preterm preterm JJ cord-021894-lq8yr710 259 42 infants infant NNS cord-021894-lq8yr710 259 43 during during IN cord-021894-lq8yr710 259 44 the the DT cord-021894-lq8yr710 259 45 first first JJ cord-021894-lq8yr710 259 46 year year NN cord-021894-lq8yr710 259 47 of of IN cord-021894-lq8yr710 259 48 life life NN cord-021894-lq8yr710 259 49 Chronic chronic JJ cord-021894-lq8yr710 259 50 diseases disease NNS cord-021894-lq8yr710 259 51 , , , cord-021894-lq8yr710 259 52 chromosomal chromosomal JJ cord-021894-lq8yr710 259 53 abnormalities abnormality NNS cord-021894-lq8yr710 259 54 , , , cord-021894-lq8yr710 259 55 and and CC cord-021894-lq8yr710 259 56 congenital congenital JJ cord-021894-lq8yr710 259 57 malformations malformation NNS cord-021894-lq8yr710 259 58 as as IN cord-021894-lq8yr710 259 59 risk risk NN cord-021894-lq8yr710 259 60 factors factor NNS cord-021894-lq8yr710 259 61 for for IN cord-021894-lq8yr710 259 62 respiratory respiratory JJ cord-021894-lq8yr710 259 63 syncytial syncytial JJ cord-021894-lq8yr710 259 64 virus virus NN cord-021894-lq8yr710 259 65 hospitalization hospitalization NN cord-021894-lq8yr710 259 66 : : : cord-021894-lq8yr710 260 1 a a DT cord-021894-lq8yr710 260 2 population population NN cord-021894-lq8yr710 260 3 - - HYPH cord-021894-lq8yr710 260 4 based base VBN cord-021894-lq8yr710 260 5 cohort cohort NN cord-021894-lq8yr710 260 6 study study NN cord-021894-lq8yr710 260 7 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 260 8 : : : cord-021894-lq8yr710 261 1 diagnosis diagnosis NN cord-021894-lq8yr710 261 2 and and CC cord-021894-lq8yr710 261 3 management management NN cord-021894-lq8yr710 261 4 in in IN cord-021894-lq8yr710 261 5 children child NNS cord-021894-lq8yr710 261 6 Prospective prospective JJ cord-021894-lq8yr710 261 7 study study NN cord-021894-lq8yr710 261 8 of of IN cord-021894-lq8yr710 261 9 healthcare healthcare NN cord-021894-lq8yr710 261 10 utilisation utilisation NN cord-021894-lq8yr710 261 11 and and CC cord-021894-lq8yr710 261 12 respiratory respiratory JJ cord-021894-lq8yr710 261 13 morbidity morbidity NN cord-021894-lq8yr710 261 14 due due IN cord-021894-lq8yr710 261 15 to to IN cord-021894-lq8yr710 261 16 RSV RSV NNP cord-021894-lq8yr710 261 17 infection infection NN cord-021894-lq8yr710 261 18 in in IN cord-021894-lq8yr710 261 19 prematurely prematurely RB cord-021894-lq8yr710 261 20 born bear VBN cord-021894-lq8yr710 261 21 infants infant NNS cord-021894-lq8yr710 261 22 Trends trend NNS cord-021894-lq8yr710 261 23 in in IN cord-021894-lq8yr710 261 24 respiratory respiratory JJ cord-021894-lq8yr710 261 25 syncytial syncytial JJ cord-021894-lq8yr710 261 26 virus virus NN cord-021894-lq8yr710 261 27 and and CC cord-021894-lq8yr710 261 28 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 261 29 hospitalization hospitalization NN cord-021894-lq8yr710 261 30 rates rate NNS cord-021894-lq8yr710 261 31 in in IN cord-021894-lq8yr710 261 32 high high JJ cord-021894-lq8yr710 261 33 - - HYPH cord-021894-lq8yr710 261 34 risk risk NN cord-021894-lq8yr710 261 35 infants infant NNS cord-021894-lq8yr710 261 36 in in IN cord-021894-lq8yr710 261 37 a a DT cord-021894-lq8yr710 261 38 United United NNP cord-021894-lq8yr710 261 39 States States NNP cord-021894-lq8yr710 261 40 Nationally Nationally NNP cord-021894-lq8yr710 261 41 Representative Representative NNP cord-021894-lq8yr710 261 42 Database Database NNP cord-021894-lq8yr710 261 43 Respiratory respiratory JJ cord-021894-lq8yr710 261 44 syncytial syncytial JJ cord-021894-lq8yr710 261 45 virus virus NN cord-021894-lq8yr710 261 46 hospitalization hospitalization NN cord-021894-lq8yr710 261 47 trends trend NNS cord-021894-lq8yr710 261 48 in in IN cord-021894-lq8yr710 261 49 infants infant NNS cord-021894-lq8yr710 261 50 with with IN cord-021894-lq8yr710 261 51 chronic chronic JJ cord-021894-lq8yr710 261 52 lung lung NN cord-021894-lq8yr710 261 53 disease disease NN cord-021894-lq8yr710 261 54 of of IN cord-021894-lq8yr710 261 55 infancy infancy NNP cord-021894-lq8yr710 262 1 Viral viral JJ cord-021894-lq8yr710 262 2 etiologies etiology NNS cord-021894-lq8yr710 262 3 of of IN cord-021894-lq8yr710 262 4 infant infant NN cord-021894-lq8yr710 262 5 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 262 6 , , , cord-021894-lq8yr710 262 7 croup croup NN cord-021894-lq8yr710 262 8 and and CC cord-021894-lq8yr710 262 9 upper upper JJ cord-021894-lq8yr710 262 10 respiratory respiratory JJ cord-021894-lq8yr710 262 11 illness illness NN cord-021894-lq8yr710 262 12 during during IN cord-021894-lq8yr710 262 13 4 4 CD cord-021894-lq8yr710 262 14 consecutive consecutive JJ cord-021894-lq8yr710 262 15 years year NNS cord-021894-lq8yr710 263 1 Viral viral JJ cord-021894-lq8yr710 263 2 etiology etiology NN cord-021894-lq8yr710 263 3 of of IN cord-021894-lq8yr710 263 4 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 263 5 among among IN cord-021894-lq8yr710 263 6 pediatric pediatric JJ cord-021894-lq8yr710 263 7 inpatients inpatient NNS cord-021894-lq8yr710 263 8 in in IN cord-021894-lq8yr710 263 9 northern northern JJ cord-021894-lq8yr710 263 10 Taiwan Taiwan NNP cord-021894-lq8yr710 263 11 with with IN cord-021894-lq8yr710 263 12 emphasis emphasis NN cord-021894-lq8yr710 263 13 on on IN cord-021894-lq8yr710 263 14 newly newly RB cord-021894-lq8yr710 263 15 identified identify VBN cord-021894-lq8yr710 263 16 respiratory respiratory JJ cord-021894-lq8yr710 263 17 viruses virus NNS cord-021894-lq8yr710 263 18 Occurrence occurrence NN cord-021894-lq8yr710 263 19 of of IN cord-021894-lq8yr710 263 20 groups group NNS cord-021894-lq8yr710 263 21 A A NNP cord-021894-lq8yr710 263 22 and and CC cord-021894-lq8yr710 263 23 B b NN cord-021894-lq8yr710 263 24 of of IN cord-021894-lq8yr710 263 25 respiratory respiratory JJ cord-021894-lq8yr710 263 26 syncytial syncytial JJ cord-021894-lq8yr710 263 27 virus virus NN cord-021894-lq8yr710 263 28 over over IN cord-021894-lq8yr710 263 29 15 15 CD cord-021894-lq8yr710 263 30 years year NNS cord-021894-lq8yr710 263 31 : : : cord-021894-lq8yr710 264 1 associated associate VBN cord-021894-lq8yr710 264 2 epidemiologic epidemiologic JJ cord-021894-lq8yr710 264 3 and and CC cord-021894-lq8yr710 264 4 clinical clinical JJ cord-021894-lq8yr710 264 5 characteristics characteristic NNS cord-021894-lq8yr710 264 6 in in IN cord-021894-lq8yr710 264 7 hospitalized hospitalize VBN cord-021894-lq8yr710 264 8 and and CC cord-021894-lq8yr710 264 9 ambulatory ambulatory JJ cord-021894-lq8yr710 264 10 children child NNS cord-021894-lq8yr710 264 11 Severity severity NN cord-021894-lq8yr710 264 12 of of IN cord-021894-lq8yr710 264 13 respiratory respiratory JJ cord-021894-lq8yr710 264 14 syncytial syncytial JJ cord-021894-lq8yr710 264 15 virus virus NN cord-021894-lq8yr710 264 16 infection infection NN cord-021894-lq8yr710 264 17 is be VBZ cord-021894-lq8yr710 264 18 related relate VBN cord-021894-lq8yr710 264 19 to to IN cord-021894-lq8yr710 264 20 virus virus NN cord-021894-lq8yr710 264 21 strain strain VB cord-021894-lq8yr710 264 22 Immunity immunity NN cord-021894-lq8yr710 264 23 to to IN cord-021894-lq8yr710 264 24 and and CC cord-021894-lq8yr710 264 25 frequency frequency NN cord-021894-lq8yr710 264 26 of of IN cord-021894-lq8yr710 264 27 reinfection reinfection NN cord-021894-lq8yr710 264 28 with with IN cord-021894-lq8yr710 264 29 respiratory respiratory JJ cord-021894-lq8yr710 264 30 syncytial syncytial JJ cord-021894-lq8yr710 264 31 virus virus NN cord-021894-lq8yr710 264 32 Association Association NNP cord-021894-lq8yr710 264 33 of of IN cord-021894-lq8yr710 264 34 rhinovirus rhinovirus NN cord-021894-lq8yr710 264 35 infection infection NN cord-021894-lq8yr710 264 36 with with IN cord-021894-lq8yr710 264 37 increased increase VBN cord-021894-lq8yr710 264 38 disease disease NN cord-021894-lq8yr710 264 39 severity severity NN cord-021894-lq8yr710 264 40 in in IN cord-021894-lq8yr710 264 41 acute acute JJ cord-021894-lq8yr710 264 42 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 264 43 Community community NN cord-021894-lq8yr710 264 44 - - HYPH cord-021894-lq8yr710 264 45 acquired acquire VBN cord-021894-lq8yr710 264 46 pneumonia pneumonia NN cord-021894-lq8yr710 264 47 requiring require VBG cord-021894-lq8yr710 264 48 hospitalization hospitalization NN cord-021894-lq8yr710 264 49 among among IN cord-021894-lq8yr710 264 50 U.S. U.S. NNP cord-021894-lq8yr710 264 51 adults adult NNS cord-021894-lq8yr710 264 52 Aetiology Aetiology NNP cord-021894-lq8yr710 264 53 of of IN cord-021894-lq8yr710 264 54 childhood childhood NN cord-021894-lq8yr710 264 55 pneumonia pneumonia NN cord-021894-lq8yr710 264 56 in in IN cord-021894-lq8yr710 264 57 a a DT cord-021894-lq8yr710 264 58 well well RB cord-021894-lq8yr710 264 59 vaccinated vaccinate VBN cord-021894-lq8yr710 264 60 South south JJ cord-021894-lq8yr710 264 61 African african JJ cord-021894-lq8yr710 264 62 birth birth NN cord-021894-lq8yr710 264 63 cohort cohort NN cord-021894-lq8yr710 264 64 : : : cord-021894-lq8yr710 264 65 a a DT cord-021894-lq8yr710 264 66 nested nested JJ cord-021894-lq8yr710 264 67 casecontrol casecontrol DT cord-021894-lq8yr710 264 68 study study NN cord-021894-lq8yr710 264 69 of of IN cord-021894-lq8yr710 264 70 the the DT cord-021894-lq8yr710 264 71 Drakenstein Drakenstein NNP cord-021894-lq8yr710 264 72 Child Child NNP cord-021894-lq8yr710 264 73 Health Health NNP cord-021894-lq8yr710 264 74 Study Study NNP cord-021894-lq8yr710 264 75 Respiratory respiratory JJ cord-021894-lq8yr710 264 76 syncytial syncytial JJ cord-021894-lq8yr710 264 77 virus virus NN cord-021894-lq8yr710 264 78 ( ( -LRB- cord-021894-lq8yr710 264 79 RSV RSV NNP cord-021894-lq8yr710 264 80 ) ) -RRB- cord-021894-lq8yr710 264 81 and and CC cord-021894-lq8yr710 264 82 its -PRON- PRP$ cord-021894-lq8yr710 264 83 propensity propensity NN cord-021894-lq8yr710 264 84 for for IN cord-021894-lq8yr710 264 85 causing cause VBG cord-021894-lq8yr710 264 86 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 264 87 Pecularities Pecularities NNP cord-021894-lq8yr710 264 88 of of IN cord-021894-lq8yr710 264 89 lesions lesion NNS cord-021894-lq8yr710 264 90 in in IN cord-021894-lq8yr710 264 91 viral viral JJ cord-021894-lq8yr710 264 92 and and CC cord-021894-lq8yr710 264 93 mycoplasma mycoplasma NN cord-021894-lq8yr710 264 94 infections infection NNS cord-021894-lq8yr710 264 95 of of IN cord-021894-lq8yr710 264 96 the the DT cord-021894-lq8yr710 264 97 respiratory respiratory JJ cord-021894-lq8yr710 264 98 tract tract NN cord-021894-lq8yr710 264 99 Recovery recovery NN cord-021894-lq8yr710 264 100 of of IN cord-021894-lq8yr710 264 101 the the DT cord-021894-lq8yr710 264 102 ciliated ciliated JJ cord-021894-lq8yr710 264 103 epithelium epithelium NN cord-021894-lq8yr710 264 104 following follow VBG cord-021894-lq8yr710 264 105 acute acute JJ cord-021894-lq8yr710 264 106 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 264 107 in in IN cord-021894-lq8yr710 264 108 infancy infancy NN cord-021894-lq8yr710 265 1 Respiratory respiratory JJ cord-021894-lq8yr710 265 2 syncytial syncytial JJ cord-021894-lq8yr710 265 3 virus virus NN cord-021894-lq8yr710 265 4 infections infection NNS cord-021894-lq8yr710 265 5 in in IN cord-021894-lq8yr710 265 6 infants infant NNS cord-021894-lq8yr710 265 7 : : : cord-021894-lq8yr710 265 8 quantitation quantitation NN cord-021894-lq8yr710 265 9 and and CC cord-021894-lq8yr710 265 10 duration duration NN cord-021894-lq8yr710 265 11 of of IN cord-021894-lq8yr710 265 12 shedding shed VBG cord-021894-lq8yr710 265 13 Respiratory respiratory JJ cord-021894-lq8yr710 265 14 syncytial syncytial JJ cord-021894-lq8yr710 265 15 virus virus NN cord-021894-lq8yr710 265 16 genomic genomic JJ cord-021894-lq8yr710 265 17 load load NN cord-021894-lq8yr710 265 18 and and CC cord-021894-lq8yr710 265 19 disease disease NN cord-021894-lq8yr710 265 20 severity severity NN cord-021894-lq8yr710 265 21 among among IN cord-021894-lq8yr710 265 22 children child NNS cord-021894-lq8yr710 265 23 hospitalized hospitalize VBN cord-021894-lq8yr710 265 24 with with IN cord-021894-lq8yr710 265 25 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 265 26 : : : cord-021894-lq8yr710 265 27 multicenter multicenter JJ cord-021894-lq8yr710 265 28 cohort cohort NN cord-021894-lq8yr710 265 29 studies study NNS cord-021894-lq8yr710 265 30 in in IN cord-021894-lq8yr710 265 31 the the DT cord-021894-lq8yr710 265 32 United United NNP cord-021894-lq8yr710 265 33 States States NNP cord-021894-lq8yr710 265 34 and and CC cord-021894-lq8yr710 265 35 Finland Finland NNP cord-021894-lq8yr710 265 36 Respiratory respiratory JJ cord-021894-lq8yr710 265 37 syncytial syncytial JJ cord-021894-lq8yr710 265 38 virus virus NN cord-021894-lq8yr710 265 39 load load NN cord-021894-lq8yr710 265 40 , , , cord-021894-lq8yr710 265 41 viral viral JJ cord-021894-lq8yr710 265 42 dynamics dynamic NNS cord-021894-lq8yr710 265 43 , , , cord-021894-lq8yr710 265 44 and and CC cord-021894-lq8yr710 265 45 disease disease NN cord-021894-lq8yr710 265 46 severity severity NN cord-021894-lq8yr710 265 47 in in IN cord-021894-lq8yr710 265 48 previously previously RB cord-021894-lq8yr710 265 49 healthy healthy JJ cord-021894-lq8yr710 265 50 naturally naturally RB cord-021894-lq8yr710 265 51 infected infect VBN cord-021894-lq8yr710 265 52 children child NNS cord-021894-lq8yr710 266 1 Type type NN cord-021894-lq8yr710 266 2 1 1 CD cord-021894-lq8yr710 266 3 and and CC cord-021894-lq8yr710 266 4 type type NN cord-021894-lq8yr710 266 5 2 2 CD cord-021894-lq8yr710 266 6 cytokine cytokine NN cord-021894-lq8yr710 266 7 imbalance imbalance NN cord-021894-lq8yr710 266 8 in in IN cord-021894-lq8yr710 266 9 acute acute JJ cord-021894-lq8yr710 266 10 respiratory respiratory JJ cord-021894-lq8yr710 266 11 syncytial syncytial JJ cord-021894-lq8yr710 266 12 virus virus NN cord-021894-lq8yr710 266 13 bronchiolitis bronchioliti VBN cord-021894-lq8yr710 266 14 Viral viral JJ cord-021894-lq8yr710 266 15 specific specific JJ cord-021894-lq8yr710 266 16 factors factor NNS cord-021894-lq8yr710 266 17 contribute contribute VBP cord-021894-lq8yr710 266 18 to to IN cord-021894-lq8yr710 266 19 clinical clinical JJ cord-021894-lq8yr710 266 20 respiratory respiratory JJ cord-021894-lq8yr710 266 21 syncytial syncytial JJ cord-021894-lq8yr710 266 22 virus virus NN cord-021894-lq8yr710 266 23 disease disease NN cord-021894-lq8yr710 266 24 severity severity NN cord-021894-lq8yr710 266 25 differences difference NNS cord-021894-lq8yr710 266 26 in in IN cord-021894-lq8yr710 266 27 infants infant NNS cord-021894-lq8yr710 266 28 Respiratory respiratory JJ cord-021894-lq8yr710 266 29 syncytial syncytial JJ cord-021894-lq8yr710 266 30 virus virus NN cord-021894-lq8yr710 266 31 disease disease NN cord-021894-lq8yr710 266 32 is be VBZ cord-021894-lq8yr710 266 33 mediated mediate VBN cord-021894-lq8yr710 266 34 by by IN cord-021894-lq8yr710 266 35 age age NN cord-021894-lq8yr710 266 36 - - HYPH cord-021894-lq8yr710 266 37 variable variable NN cord-021894-lq8yr710 266 38 IL-33 IL-33 NNP cord-021894-lq8yr710 267 1 Surfactant surfactant NN cord-021894-lq8yr710 267 2 protein protein NN cord-021894-lq8yr710 267 3 A2 a2 NN cord-021894-lq8yr710 267 4 polymorphisms polymorphism NNS cord-021894-lq8yr710 267 5 and and CC cord-021894-lq8yr710 267 6 disease disease NN cord-021894-lq8yr710 267 7 severity severity NN cord-021894-lq8yr710 267 8 in in IN cord-021894-lq8yr710 267 9 a a DT cord-021894-lq8yr710 267 10 respiratory respiratory JJ cord-021894-lq8yr710 267 11 syncytial syncytial JJ cord-021894-lq8yr710 267 12 virus virus NN cord-021894-lq8yr710 267 13 - - HYPH cord-021894-lq8yr710 267 14 infected infect VBN cord-021894-lq8yr710 267 15 population population NN cord-021894-lq8yr710 267 16 Latitudinal Latitudinal NNP cord-021894-lq8yr710 267 17 variations variation NNS cord-021894-lq8yr710 267 18 in in IN cord-021894-lq8yr710 267 19 seasonal seasonal JJ cord-021894-lq8yr710 267 20 activity activity NN cord-021894-lq8yr710 267 21 of of IN cord-021894-lq8yr710 267 22 influenza influenza NN cord-021894-lq8yr710 267 23 and and CC cord-021894-lq8yr710 267 24 respiratory respiratory JJ cord-021894-lq8yr710 267 25 syncytial syncytial JJ cord-021894-lq8yr710 267 26 virus virus NN cord-021894-lq8yr710 267 27 ( ( -LRB- cord-021894-lq8yr710 267 28 RSV RSV NNP cord-021894-lq8yr710 267 29 ) ) -RRB- cord-021894-lq8yr710 267 30 : : : cord-021894-lq8yr710 267 31 a a DT cord-021894-lq8yr710 267 32 global global JJ cord-021894-lq8yr710 267 33 comparative comparative JJ cord-021894-lq8yr710 267 34 review review NN cord-021894-lq8yr710 267 35 Altitude altitude NN cord-021894-lq8yr710 267 36 and and CC cord-021894-lq8yr710 267 37 environmental environmental JJ cord-021894-lq8yr710 267 38 climate climate NN cord-021894-lq8yr710 267 39 effects effect NNS cord-021894-lq8yr710 267 40 on on IN cord-021894-lq8yr710 267 41 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 42 severity severity NN cord-021894-lq8yr710 267 43 among among IN cord-021894-lq8yr710 267 44 children child NNS cord-021894-lq8yr710 267 45 presenting present VBG cord-021894-lq8yr710 267 46 to to IN cord-021894-lq8yr710 267 47 the the DT cord-021894-lq8yr710 267 48 emergency emergency NN cord-021894-lq8yr710 267 49 department department NN cord-021894-lq8yr710 267 50 Environmental environmental JJ cord-021894-lq8yr710 267 51 drivers driver NNS cord-021894-lq8yr710 267 52 of of IN cord-021894-lq8yr710 267 53 the the DT cord-021894-lq8yr710 267 54 spatiotemporal spatiotemporal JJ cord-021894-lq8yr710 267 55 dynamics dynamic NNS cord-021894-lq8yr710 267 56 of of IN cord-021894-lq8yr710 267 57 respiratory respiratory JJ cord-021894-lq8yr710 267 58 syncytial syncytial JJ cord-021894-lq8yr710 267 59 virus virus NN cord-021894-lq8yr710 267 60 in in IN cord-021894-lq8yr710 267 61 the the DT cord-021894-lq8yr710 267 62 United United NNP cord-021894-lq8yr710 267 63 States States NNP cord-021894-lq8yr710 267 64 Viral Viral NNP cord-021894-lq8yr710 267 65 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 66 in in IN cord-021894-lq8yr710 267 67 children child NNS cord-021894-lq8yr710 267 68 Epidemiology Epidemiology NNP cord-021894-lq8yr710 267 69 of of IN cord-021894-lq8yr710 267 70 respiratory respiratory JJ cord-021894-lq8yr710 267 71 syncytial syncytial JJ cord-021894-lq8yr710 267 72 virus virus NN cord-021894-lq8yr710 267 73 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 74 in in IN cord-021894-lq8yr710 267 75 hospitalized hospitalize VBN cord-021894-lq8yr710 267 76 infants infant NNS cord-021894-lq8yr710 267 77 in in IN cord-021894-lq8yr710 267 78 Greece Greece NNP cord-021894-lq8yr710 267 79 Duration Duration NNP cord-021894-lq8yr710 267 80 of of IN cord-021894-lq8yr710 267 81 illness illness NN cord-021894-lq8yr710 267 82 in in IN cord-021894-lq8yr710 267 83 ambulatory ambulatory JJ cord-021894-lq8yr710 267 84 children child NNS cord-021894-lq8yr710 267 85 diagnosed diagnose VBN cord-021894-lq8yr710 267 86 with with IN cord-021894-lq8yr710 267 87 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 88 Duration duration NN cord-021894-lq8yr710 267 89 of of IN cord-021894-lq8yr710 267 90 illness illness NN cord-021894-lq8yr710 267 91 in in IN cord-021894-lq8yr710 267 92 infants infant NNS cord-021894-lq8yr710 267 93 with with IN cord-021894-lq8yr710 267 94 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 95 evaluated evaluate VBN cord-021894-lq8yr710 267 96 in in IN cord-021894-lq8yr710 267 97 the the DT cord-021894-lq8yr710 267 98 emergency emergency NN cord-021894-lq8yr710 267 99 department department NN cord-021894-lq8yr710 267 100 The the DT cord-021894-lq8yr710 267 101 clinical clinical JJ cord-021894-lq8yr710 267 102 burden burden NN cord-021894-lq8yr710 267 103 of of IN cord-021894-lq8yr710 267 104 respiratory respiratory JJ cord-021894-lq8yr710 267 105 syncytial syncytial JJ cord-021894-lq8yr710 267 106 virus virus NN cord-021894-lq8yr710 267 107 ( ( -LRB- cord-021894-lq8yr710 267 108 RSV RSV NNP cord-021894-lq8yr710 267 109 ) ) -RRB- cord-021894-lq8yr710 267 110 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 267 111 among among IN cord-021894-lq8yr710 267 112 infants infant NNS cord-021894-lq8yr710 267 113 in in IN cord-021894-lq8yr710 267 114 the the DT cord-021894-lq8yr710 267 115 United United NNP cord-021894-lq8yr710 267 116 Kingdom Kingdom NNP cord-021894-lq8yr710 267 117 ( ( -LRB- cord-021894-lq8yr710 267 118 UK UK NNP cord-021894-lq8yr710 267 119 ) ) -RRB- cord-021894-lq8yr710 267 120 [ [ -LRB- cord-021894-lq8yr710 267 121 PhD PhD NNP cord-021894-lq8yr710 267 122 ] ] -RRB- cord-021894-lq8yr710 267 123 : : : cord-021894-lq8yr710 267 124 Imperial Imperial NNP cord-021894-lq8yr710 267 125 College College NNP cord-021894-lq8yr710 267 126 Epidemiology Epidemiology NNP cord-021894-lq8yr710 267 127 of of IN cord-021894-lq8yr710 267 128 respiratory respiratory JJ cord-021894-lq8yr710 267 129 syncytial syncytial JJ cord-021894-lq8yr710 267 130 virus virus NN cord-021894-lq8yr710 267 131 infection infection NN cord-021894-lq8yr710 267 132 in in IN cord-021894-lq8yr710 267 133 Washington Washington NNP cord-021894-lq8yr710 267 134 , , , cord-021894-lq8yr710 267 135 DC DC NNP cord-021894-lq8yr710 267 136 . . . cord-021894-lq8yr710 268 1 II II NNP cord-021894-lq8yr710 268 2 . . . cord-021894-lq8yr710 269 1 Infection infection NN cord-021894-lq8yr710 269 2 and and CC cord-021894-lq8yr710 269 3 disease disease NN cord-021894-lq8yr710 269 4 with with IN cord-021894-lq8yr710 269 5 respect respect NN cord-021894-lq8yr710 269 6 to to IN cord-021894-lq8yr710 269 7 age age NN cord-021894-lq8yr710 269 8 , , , cord-021894-lq8yr710 269 9 immunologic immunologic JJ cord-021894-lq8yr710 269 10 status status NN cord-021894-lq8yr710 269 11 , , , cord-021894-lq8yr710 269 12 race race NN cord-021894-lq8yr710 269 13 and and CC cord-021894-lq8yr710 269 14 sex sex NN cord-021894-lq8yr710 269 15 A a DT cord-021894-lq8yr710 269 16 comparison comparison NN cord-021894-lq8yr710 269 17 of of IN cord-021894-lq8yr710 269 18 the the DT cord-021894-lq8yr710 269 19 recording recording NN cord-021894-lq8yr710 269 20 of of IN cord-021894-lq8yr710 269 21 30 30 CD cord-021894-lq8yr710 269 22 common common JJ cord-021894-lq8yr710 269 23 childhood childhood NN cord-021894-lq8yr710 269 24 conditions condition NNS cord-021894-lq8yr710 269 25 in in IN cord-021894-lq8yr710 269 26 the the DT cord-021894-lq8yr710 269 27 Doctor Doctor NNP cord-021894-lq8yr710 269 28 's 's POS cord-021894-lq8yr710 269 29 Independent Independent NNP cord-021894-lq8yr710 269 30 Network Network NNP cord-021894-lq8yr710 269 31 and and CC cord-021894-lq8yr710 269 32 General General NNP cord-021894-lq8yr710 269 33 Practice Practice NNP cord-021894-lq8yr710 269 34 Research Research NNP cord-021894-lq8yr710 269 35 Databases Databases NNPS cord-021894-lq8yr710 270 1 Viral viral JJ cord-021894-lq8yr710 270 2 respiratory respiratory JJ cord-021894-lq8yr710 270 3 tract tract NN cord-021894-lq8yr710 270 4 infections infection NNS cord-021894-lq8yr710 270 5 in in IN cord-021894-lq8yr710 270 6 the the DT cord-021894-lq8yr710 270 7 first first JJ cord-021894-lq8yr710 270 8 six six CD cord-021894-lq8yr710 270 9 months month NNS cord-021894-lq8yr710 270 10 of of IN cord-021894-lq8yr710 270 11 life life NN cord-021894-lq8yr710 270 12 Evaluation Evaluation NNP cord-021894-lq8yr710 270 13 of of IN cord-021894-lq8yr710 270 14 hospitalized hospitalize VBN cord-021894-lq8yr710 270 15 infants infant NNS cord-021894-lq8yr710 270 16 and and CC cord-021894-lq8yr710 270 17 young young JJ cord-021894-lq8yr710 270 18 children child NNS cord-021894-lq8yr710 270 19 with with IN cord-021894-lq8yr710 270 20 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 270 21 - - : cord-021894-lq8yr710 270 22 a a DT cord-021894-lq8yr710 270 23 multi multi JJ cord-021894-lq8yr710 270 24 centre centre NN cord-021894-lq8yr710 270 25 study study NN cord-021894-lq8yr710 270 26 Trends trend NNS cord-021894-lq8yr710 270 27 in in IN cord-021894-lq8yr710 270 28 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 270 29 hospitalizations hospitalization NNS cord-021894-lq8yr710 270 30 in in IN cord-021894-lq8yr710 270 31 the the DT cord-021894-lq8yr710 270 32 United United NNP cord-021894-lq8yr710 270 33 States States NNP cord-021894-lq8yr710 270 34 Admission Admission NNP cord-021894-lq8yr710 270 35 to to IN cord-021894-lq8yr710 270 36 hospital hospital NN cord-021894-lq8yr710 270 37 for for IN cord-021894-lq8yr710 270 38 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 270 39 in in IN cord-021894-lq8yr710 270 40 England England NNP cord-021894-lq8yr710 270 41 : : : cord-021894-lq8yr710 270 42 trends trend NNS cord-021894-lq8yr710 270 43 over over IN cord-021894-lq8yr710 270 44 five five CD cord-021894-lq8yr710 270 45 decades decade NNS cord-021894-lq8yr710 270 46 , , , cord-021894-lq8yr710 270 47 geographical geographical JJ cord-021894-lq8yr710 270 48 variation variation NN cord-021894-lq8yr710 270 49 and and CC cord-021894-lq8yr710 270 50 association association NN cord-021894-lq8yr710 270 51 with with IN cord-021894-lq8yr710 270 52 perinatal perinatal JJ cord-021894-lq8yr710 270 53 characteristics characteristic NNS cord-021894-lq8yr710 270 54 and and CC cord-021894-lq8yr710 270 55 subsequent subsequent JJ cord-021894-lq8yr710 270 56 asthma asthma NN cord-021894-lq8yr710 270 57 Risk risk NN cord-021894-lq8yr710 270 58 factors factor NNS cord-021894-lq8yr710 270 59 for for IN cord-021894-lq8yr710 270 60 hospital hospital NN cord-021894-lq8yr710 270 61 admission admission NN cord-021894-lq8yr710 270 62 with with IN cord-021894-lq8yr710 270 63 RSV RSV NNP cord-021894-lq8yr710 270 64 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 270 65 in in IN cord-021894-lq8yr710 270 66 England England NNP cord-021894-lq8yr710 270 67 : : : cord-021894-lq8yr710 271 1 a a DT cord-021894-lq8yr710 271 2 population population NN cord-021894-lq8yr710 271 3 - - HYPH cord-021894-lq8yr710 271 4 based base VBN cord-021894-lq8yr710 271 5 birth birth NN cord-021894-lq8yr710 271 6 cohort cohort NN cord-021894-lq8yr710 271 7 study study VB cord-021894-lq8yr710 271 8 International international JJ cord-021894-lq8yr710 271 9 variation variation NN cord-021894-lq8yr710 271 10 in in IN cord-021894-lq8yr710 271 11 the the DT cord-021894-lq8yr710 271 12 management management NN cord-021894-lq8yr710 271 13 of of IN cord-021894-lq8yr710 271 14 infants infant NNS cord-021894-lq8yr710 271 15 hospitalized hospitalize VBN cord-021894-lq8yr710 271 16 with with IN cord-021894-lq8yr710 271 17 respiratory respiratory JJ cord-021894-lq8yr710 271 18 syncytial syncytial JJ cord-021894-lq8yr710 271 19 virus virus NN cord-021894-lq8yr710 271 20 . . . cord-021894-lq8yr710 272 1 International International NNP cord-021894-lq8yr710 272 2 RSV RSV NNP cord-021894-lq8yr710 272 3 Study Study NNP cord-021894-lq8yr710 272 4 Group Group NNP cord-021894-lq8yr710 273 1 The the DT cord-021894-lq8yr710 273 2 risk risk NN cord-021894-lq8yr710 273 3 of of IN cord-021894-lq8yr710 273 4 mortality mortality NN cord-021894-lq8yr710 273 5 among among IN cord-021894-lq8yr710 273 6 young young JJ cord-021894-lq8yr710 273 7 children child NNS cord-021894-lq8yr710 273 8 hospitalized hospitalize VBN cord-021894-lq8yr710 273 9 for for IN cord-021894-lq8yr710 273 10 severe severe JJ cord-021894-lq8yr710 273 11 respiratory respiratory JJ cord-021894-lq8yr710 273 12 syncytial syncytial JJ cord-021894-lq8yr710 273 13 virus virus NN cord-021894-lq8yr710 273 14 infection infection NN cord-021894-lq8yr710 273 15 Risk risk NN cord-021894-lq8yr710 273 16 of of IN cord-021894-lq8yr710 273 17 primary primary JJ cord-021894-lq8yr710 273 18 infection infection NN cord-021894-lq8yr710 273 19 and and CC cord-021894-lq8yr710 273 20 reinfection reinfection NN cord-021894-lq8yr710 273 21 with with IN cord-021894-lq8yr710 273 22 respiratory respiratory JJ cord-021894-lq8yr710 273 23 syncytial syncytial JJ cord-021894-lq8yr710 273 24 virus virus NN cord-021894-lq8yr710 273 25 Respiratory Respiratory NNP cord-021894-lq8yr710 273 26 - - HYPH cord-021894-lq8yr710 273 27 syncytialvirus syncytialvirus JJ cord-021894-lq8yr710 273 28 infections infection NNS cord-021894-lq8yr710 273 29 , , , cord-021894-lq8yr710 273 30 reinfections reinfection NNS cord-021894-lq8yr710 273 31 and and CC cord-021894-lq8yr710 273 32 immunity immunity NN cord-021894-lq8yr710 273 33 . . . cord-021894-lq8yr710 274 1 A a DT cord-021894-lq8yr710 274 2 prospective prospective JJ cord-021894-lq8yr710 274 3 , , , cord-021894-lq8yr710 274 4 longitudinal longitudinal JJ cord-021894-lq8yr710 274 5 study study NN cord-021894-lq8yr710 274 6 in in IN cord-021894-lq8yr710 274 7 young young JJ cord-021894-lq8yr710 274 8 children child NNS cord-021894-lq8yr710 274 9 Global global JJ cord-021894-lq8yr710 274 10 burden burden NN cord-021894-lq8yr710 274 11 of of IN cord-021894-lq8yr710 274 12 acute acute JJ cord-021894-lq8yr710 274 13 lower low JJR cord-021894-lq8yr710 274 14 respiratory respiratory JJ cord-021894-lq8yr710 274 15 infections infection NNS cord-021894-lq8yr710 274 16 due due JJ cord-021894-lq8yr710 274 17 to to IN cord-021894-lq8yr710 274 18 respiratory respiratory JJ cord-021894-lq8yr710 274 19 syncytial syncytial JJ cord-021894-lq8yr710 274 20 virus virus NN cord-021894-lq8yr710 274 21 in in IN cord-021894-lq8yr710 274 22 young young JJ cord-021894-lq8yr710 274 23 children child NNS cord-021894-lq8yr710 274 24 : : : cord-021894-lq8yr710 274 25 a a DT cord-021894-lq8yr710 274 26 systematic systematic JJ cord-021894-lq8yr710 274 27 review review NN cord-021894-lq8yr710 274 28 and and CC cord-021894-lq8yr710 274 29 meta meta NNP cord-021894-lq8yr710 274 30 - - HYPH cord-021894-lq8yr710 274 31 analysis analysis NN cord-021894-lq8yr710 275 1 The the DT cord-021894-lq8yr710 275 2 burden burden NN cord-021894-lq8yr710 275 3 of of IN cord-021894-lq8yr710 275 4 respiratory respiratory JJ cord-021894-lq8yr710 275 5 syncytial syncytial JJ cord-021894-lq8yr710 275 6 virus virus NN cord-021894-lq8yr710 275 7 infection infection NN cord-021894-lq8yr710 275 8 in in IN cord-021894-lq8yr710 275 9 young young JJ cord-021894-lq8yr710 275 10 children child NNS cord-021894-lq8yr710 275 11 Hospitalizations hospitalization NNS cord-021894-lq8yr710 275 12 associated associate VBN cord-021894-lq8yr710 275 13 with with IN cord-021894-lq8yr710 275 14 influenza influenza NN cord-021894-lq8yr710 275 15 and and CC cord-021894-lq8yr710 275 16 respiratory respiratory JJ cord-021894-lq8yr710 275 17 syncytial syncytial JJ cord-021894-lq8yr710 275 18 virus virus NN cord-021894-lq8yr710 275 19 in in IN cord-021894-lq8yr710 275 20 the the DT cord-021894-lq8yr710 275 21 United United NNP cord-021894-lq8yr710 275 22 States States NNP cord-021894-lq8yr710 275 23 Increased increase VBD cord-021894-lq8yr710 275 24 risk risk NN cord-021894-lq8yr710 275 25 of of IN cord-021894-lq8yr710 275 26 wheeze wheeze NN cord-021894-lq8yr710 275 27 and and CC cord-021894-lq8yr710 275 28 decreased decrease VBD cord-021894-lq8yr710 275 29 lung lung NN cord-021894-lq8yr710 275 30 function function NN cord-021894-lq8yr710 275 31 after after IN cord-021894-lq8yr710 275 32 respiratory respiratory JJ cord-021894-lq8yr710 275 33 syncytial syncytial JJ cord-021894-lq8yr710 275 34 virus virus NN cord-021894-lq8yr710 275 35 infection infection NN cord-021894-lq8yr710 275 36 G489 g489 CD cord-021894-lq8yr710 275 37 blood blood NN cord-021894-lq8yr710 275 38 gas gas NN cord-021894-lq8yr710 275 39 analysis analysis NN cord-021894-lq8yr710 275 40 in in IN cord-021894-lq8yr710 275 41 acute acute JJ cord-021894-lq8yr710 275 42 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 275 43 - - : cord-021894-lq8yr710 275 44 who who WP cord-021894-lq8yr710 275 45 and and CC cord-021894-lq8yr710 275 46 when when WRB cord-021894-lq8yr710 275 47 ? ? . cord-021894-lq8yr710 276 1 A a DT cord-021894-lq8yr710 276 2 clustering clustering NN cord-021894-lq8yr710 276 3 approach approach NN cord-021894-lq8yr710 276 4 to to TO cord-021894-lq8yr710 276 5 identify identify VB cord-021894-lq8yr710 276 6 severe severe JJ cord-021894-lq8yr710 276 7 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 8 profiles profile NNS cord-021894-lq8yr710 276 9 in in IN cord-021894-lq8yr710 276 10 children child NNS cord-021894-lq8yr710 276 11 Deciphering decipher VBG cord-021894-lq8yr710 276 12 clinical clinical JJ cord-021894-lq8yr710 276 13 phenotypes phenotype NNS cord-021894-lq8yr710 276 14 in in IN cord-021894-lq8yr710 276 15 acute acute JJ cord-021894-lq8yr710 276 16 viral viral JJ cord-021894-lq8yr710 276 17 lower low JJR cord-021894-lq8yr710 276 18 respiratory respiratory JJ cord-021894-lq8yr710 276 19 tract tract NN cord-021894-lq8yr710 276 20 infection infection NN cord-021894-lq8yr710 276 21 : : : cord-021894-lq8yr710 276 22 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 276 23 is be VBZ cord-021894-lq8yr710 276 24 not not RB cord-021894-lq8yr710 276 25 an an DT cord-021894-lq8yr710 276 26 island island NN cord-021894-lq8yr710 276 27 Variability variability NN cord-021894-lq8yr710 276 28 in in IN cord-021894-lq8yr710 276 29 the the DT cord-021894-lq8yr710 276 30 diagnostic diagnostic JJ cord-021894-lq8yr710 276 31 labeling labeling NN cord-021894-lq8yr710 276 32 of of IN cord-021894-lq8yr710 276 33 nonbacterial nonbacterial JJ cord-021894-lq8yr710 276 34 lower low JJR cord-021894-lq8yr710 276 35 respiratory respiratory JJ cord-021894-lq8yr710 276 36 tract tract NN cord-021894-lq8yr710 276 37 infections infection NNS cord-021894-lq8yr710 276 38 : : : cord-021894-lq8yr710 276 39 a a DT cord-021894-lq8yr710 276 40 multicenter multicenter JJ cord-021894-lq8yr710 276 41 study study NN cord-021894-lq8yr710 276 42 of of IN cord-021894-lq8yr710 276 43 children child NNS cord-021894-lq8yr710 276 44 who who WP cord-021894-lq8yr710 276 45 presented present VBD cord-021894-lq8yr710 276 46 to to IN cord-021894-lq8yr710 276 47 the the DT cord-021894-lq8yr710 276 48 emergency emergency NN cord-021894-lq8yr710 276 49 department department NN cord-021894-lq8yr710 276 50 South south JJ cord-021894-lq8yr710 276 51 African african JJ cord-021894-lq8yr710 276 52 guideline guideline NN cord-021894-lq8yr710 276 53 for for IN cord-021894-lq8yr710 276 54 the the DT cord-021894-lq8yr710 276 55 diagnosis diagnosis NN cord-021894-lq8yr710 276 56 , , , cord-021894-lq8yr710 276 57 management management NN cord-021894-lq8yr710 276 58 and and CC cord-021894-lq8yr710 276 59 prevention prevention NN cord-021894-lq8yr710 276 60 of of IN cord-021894-lq8yr710 276 61 acute acute JJ cord-021894-lq8yr710 276 62 viral viral JJ cord-021894-lq8yr710 276 63 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 64 in in IN cord-021894-lq8yr710 276 65 children child NNS cord-021894-lq8yr710 276 66 Rapid Rapid NNP cord-021894-lq8yr710 276 67 point point NN cord-021894-lq8yr710 276 68 of of IN cord-021894-lq8yr710 276 69 care care NN cord-021894-lq8yr710 276 70 diagnostic diagnostic JJ cord-021894-lq8yr710 276 71 tests test NNS cord-021894-lq8yr710 276 72 for for IN cord-021894-lq8yr710 276 73 viral viral JJ cord-021894-lq8yr710 276 74 and and CC cord-021894-lq8yr710 276 75 bacterial bacterial JJ cord-021894-lq8yr710 276 76 respiratory respiratory JJ cord-021894-lq8yr710 276 77 tract tract NN cord-021894-lq8yr710 276 78 infections infection NNS cord-021894-lq8yr710 276 79 - - : cord-021894-lq8yr710 276 80 needs need NNS cord-021894-lq8yr710 276 81 , , , cord-021894-lq8yr710 276 82 advances advance NNS cord-021894-lq8yr710 276 83 , , , cord-021894-lq8yr710 276 84 and and CC cord-021894-lq8yr710 276 85 future future JJ cord-021894-lq8yr710 276 86 prospects prospect NNS cord-021894-lq8yr710 276 87 Co Co NNS cord-021894-lq8yr710 276 88 - - NNS cord-021894-lq8yr710 276 89 infections infection NNS cord-021894-lq8yr710 276 90 in in IN cord-021894-lq8yr710 276 91 children child NNS cord-021894-lq8yr710 276 92 hospitalised hospitalise VBN cord-021894-lq8yr710 276 93 for for IN cord-021894-lq8yr710 276 94 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 95 : : : cord-021894-lq8yr710 276 96 role role NN cord-021894-lq8yr710 276 97 of of IN cord-021894-lq8yr710 276 98 roomsharing roomshare VBG cord-021894-lq8yr710 276 99 Antibiotics antibiotic NNS cord-021894-lq8yr710 276 100 for for IN cord-021894-lq8yr710 276 101 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 102 in in IN cord-021894-lq8yr710 276 103 children child NNS cord-021894-lq8yr710 276 104 under under IN cord-021894-lq8yr710 276 105 two two CD cord-021894-lq8yr710 276 106 years year NNS cord-021894-lq8yr710 276 107 of of IN cord-021894-lq8yr710 276 108 age age NN cord-021894-lq8yr710 276 109 High high JJ cord-021894-lq8yr710 276 110 incidence incidence NN cord-021894-lq8yr710 276 111 of of IN cord-021894-lq8yr710 276 112 pulmonary pulmonary JJ cord-021894-lq8yr710 276 113 bacterial bacterial JJ cord-021894-lq8yr710 276 114 co co NN cord-021894-lq8yr710 276 115 - - NN cord-021894-lq8yr710 276 116 infection infection NN cord-021894-lq8yr710 276 117 in in IN cord-021894-lq8yr710 276 118 children child NNS cord-021894-lq8yr710 276 119 with with IN cord-021894-lq8yr710 276 120 severe severe JJ cord-021894-lq8yr710 276 121 respiratory respiratory JJ cord-021894-lq8yr710 276 122 syncytial syncytial JJ cord-021894-lq8yr710 276 123 virus virus NN cord-021894-lq8yr710 276 124 ( ( -LRB- cord-021894-lq8yr710 276 125 RSV RSV NNP cord-021894-lq8yr710 276 126 ) ) -RRB- cord-021894-lq8yr710 276 127 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 128 Pulmonary pulmonary JJ cord-021894-lq8yr710 276 129 and and CC cord-021894-lq8yr710 276 130 systemic systemic JJ cord-021894-lq8yr710 276 131 bacterial bacterial JJ cord-021894-lq8yr710 276 132 co co NNS cord-021894-lq8yr710 276 133 - - NNS cord-021894-lq8yr710 276 134 infections infection NNS cord-021894-lq8yr710 276 135 in in IN cord-021894-lq8yr710 276 136 severe severe JJ cord-021894-lq8yr710 276 137 RSV RSV NNP cord-021894-lq8yr710 276 138 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 139 Concurrent concurrent JJ cord-021894-lq8yr710 276 140 bacterial bacterial JJ cord-021894-lq8yr710 276 141 infection infection NN cord-021894-lq8yr710 276 142 and and CC cord-021894-lq8yr710 276 143 prolonged prolong VBN cord-021894-lq8yr710 276 144 mechanical mechanical JJ cord-021894-lq8yr710 276 145 ventilation ventilation NN cord-021894-lq8yr710 276 146 in in IN cord-021894-lq8yr710 276 147 infants infant NNS cord-021894-lq8yr710 276 148 with with IN cord-021894-lq8yr710 276 149 respiratory respiratory JJ cord-021894-lq8yr710 276 150 syncytial syncytial JJ cord-021894-lq8yr710 276 151 virus virus NN cord-021894-lq8yr710 276 152 lower low JJR cord-021894-lq8yr710 276 153 respiratory respiratory JJ cord-021894-lq8yr710 276 154 tract tract NN cord-021894-lq8yr710 276 155 disease disease NN cord-021894-lq8yr710 276 156 Nasogastric nasogastric NN cord-021894-lq8yr710 276 157 hydration hydration NN cord-021894-lq8yr710 276 158 versus versus IN cord-021894-lq8yr710 276 159 intravenous intravenous JJ cord-021894-lq8yr710 276 160 hydration hydration NN cord-021894-lq8yr710 276 161 for for IN cord-021894-lq8yr710 276 162 infants infant NNS cord-021894-lq8yr710 276 163 with with IN cord-021894-lq8yr710 276 164 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 165 : : : cord-021894-lq8yr710 276 166 a a DT cord-021894-lq8yr710 276 167 randomised randomised JJ cord-021894-lq8yr710 276 168 trial trial NN cord-021894-lq8yr710 276 169 Oxygen oxygen NN cord-021894-lq8yr710 276 170 saturation saturation NN cord-021894-lq8yr710 276 171 targets target NNS cord-021894-lq8yr710 276 172 in in IN cord-021894-lq8yr710 276 173 infants infant NNS cord-021894-lq8yr710 276 174 with with IN cord-021894-lq8yr710 276 175 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 176 ( ( -LRB- cord-021894-lq8yr710 276 177 BIDS BIDS NNP cord-021894-lq8yr710 276 178 ) ) -RRB- cord-021894-lq8yr710 276 179 : : : cord-021894-lq8yr710 276 180 a a DT cord-021894-lq8yr710 276 181 double double JJ cord-021894-lq8yr710 276 182 - - HYPH cord-021894-lq8yr710 276 183 blind blind JJ cord-021894-lq8yr710 276 184 , , , cord-021894-lq8yr710 276 185 randomised randomised JJ cord-021894-lq8yr710 276 186 , , , cord-021894-lq8yr710 276 187 equivalence equivalence NN cord-021894-lq8yr710 276 188 trial trial NN cord-021894-lq8yr710 276 189 Predictors predictor NNS cord-021894-lq8yr710 276 190 of of IN cord-021894-lq8yr710 276 191 major major JJ cord-021894-lq8yr710 276 192 intervention intervention NN cord-021894-lq8yr710 276 193 in in IN cord-021894-lq8yr710 276 194 infants infant NNS cord-021894-lq8yr710 276 195 with with IN cord-021894-lq8yr710 276 196 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 197 Intermittent intermittent JJ cord-021894-lq8yr710 276 198 monitoring monitoring NN cord-021894-lq8yr710 276 199 of of IN cord-021894-lq8yr710 276 200 oxygen oxygen NN cord-021894-lq8yr710 276 201 saturation saturation NN cord-021894-lq8yr710 276 202 in in IN cord-021894-lq8yr710 276 203 infants infant NNS cord-021894-lq8yr710 276 204 and and CC cord-021894-lq8yr710 276 205 children child NNS cord-021894-lq8yr710 276 206 with with IN cord-021894-lq8yr710 276 207 acute acute JJ cord-021894-lq8yr710 276 208 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 276 209 : : : cord-021894-lq8yr710 276 210 peekaboo peekaboo NNP cord-021894-lq8yr710 276 211 pediatrics pediatric NNS cord-021894-lq8yr710 276 212 or or CC cord-021894-lq8yr710 276 213 good good JJ cord-021894-lq8yr710 276 214 clinical clinical JJ cord-021894-lq8yr710 276 215 care care NN cord-021894-lq8yr710 276 216 ? ? . cord-021894-lq8yr710 277 1 Racemic racemic JJ cord-021894-lq8yr710 277 2 adrenaline adrenaline NN cord-021894-lq8yr710 277 3 and and CC cord-021894-lq8yr710 277 4 inhalation inhalation NN cord-021894-lq8yr710 277 5 strategies strategy NNS cord-021894-lq8yr710 277 6 in in IN cord-021894-lq8yr710 277 7 acute acute JJ cord-021894-lq8yr710 277 8 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 277 9 Variability variability NN cord-021894-lq8yr710 277 10 in in IN cord-021894-lq8yr710 277 11 inpatient inpatient JJ cord-021894-lq8yr710 277 12 management management NN cord-021894-lq8yr710 277 13 of of IN cord-021894-lq8yr710 277 14 children child NNS cord-021894-lq8yr710 277 15 hospitalized hospitalize VBN cord-021894-lq8yr710 277 16 with with IN cord-021894-lq8yr710 277 17 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 277 18 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 277 19 in in IN cord-021894-lq8yr710 277 20 children child NNS cord-021894-lq8yr710 277 21 : : : cord-021894-lq8yr710 277 22 summary summary NN cord-021894-lq8yr710 277 23 of of IN cord-021894-lq8yr710 277 24 NICE nice JJ cord-021894-lq8yr710 277 25 guidance guidance NN cord-021894-lq8yr710 277 26 Clinical clinical JJ cord-021894-lq8yr710 277 27 practice practice NN cord-021894-lq8yr710 277 28 guideline guideline NN cord-021894-lq8yr710 277 29 : : : cord-021894-lq8yr710 277 30 the the DT cord-021894-lq8yr710 277 31 diagnosis diagnosis NN cord-021894-lq8yr710 277 32 , , , cord-021894-lq8yr710 277 33 management management NN cord-021894-lq8yr710 277 34 , , , cord-021894-lq8yr710 277 35 and and CC cord-021894-lq8yr710 277 36 prevention prevention NN cord-021894-lq8yr710 277 37 of of IN cord-021894-lq8yr710 277 38 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 277 39 Clinical clinical JJ cord-021894-lq8yr710 277 40 practice practice NN cord-021894-lq8yr710 277 41 guideline guideline NN cord-021894-lq8yr710 277 42 on on IN cord-021894-lq8yr710 277 43 acute acute JJ cord-021894-lq8yr710 277 44 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 277 45 . . . cord-021894-lq8yr710 278 1 clinical clinical JJ cord-021894-lq8yr710 278 2 practice practice NN cord-021894-lq8yr710 278 3 guidelines guideline NNS cord-021894-lq8yr710 278 4 in in IN cord-021894-lq8yr710 278 5 the the DT cord-021894-lq8yr710 278 6 Spanish Spanish NNP cord-021894-lq8yr710 278 7 National National NNP cord-021894-lq8yr710 278 8 Healthcare Healthcare NNP cord-021894-lq8yr710 278 9 System System NNP cord-021894-lq8yr710 278 10 Finnish finnish JJ cord-021894-lq8yr710 278 11 guidelines guideline NNS cord-021894-lq8yr710 278 12 for for IN cord-021894-lq8yr710 278 13 the the DT cord-021894-lq8yr710 278 14 treatment treatment NN cord-021894-lq8yr710 278 15 of of IN cord-021894-lq8yr710 278 16 laryngitis laryngitis NN cord-021894-lq8yr710 278 17 , , , cord-021894-lq8yr710 278 18 wheezing wheeze VBG cord-021894-lq8yr710 278 19 bronchitis bronchitis NN cord-021894-lq8yr710 278 20 and and CC cord-021894-lq8yr710 278 21 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 278 22 in in IN cord-021894-lq8yr710 278 23 children child NNS cord-021894-lq8yr710 278 24 Acute acute JJ cord-021894-lq8yr710 278 25 viral viral JJ cord-021894-lq8yr710 278 26 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 278 27 in in IN cord-021894-lq8yr710 278 28 South South NNP cord-021894-lq8yr710 278 29 Africa Africa NNP cord-021894-lq8yr710 278 30 : : : cord-021894-lq8yr710 278 31 strategies strategy NNS cord-021894-lq8yr710 278 32 for for IN cord-021894-lq8yr710 278 33 management management NN cord-021894-lq8yr710 278 34 and and CC cord-021894-lq8yr710 278 35 prevention prevention NN cord-021894-lq8yr710 278 36 Allergic allergic JJ cord-021894-lq8yr710 278 37 diseases disease NNS cord-021894-lq8yr710 278 38 and and CC cord-021894-lq8yr710 278 39 the the DT cord-021894-lq8yr710 278 40 effect effect NN cord-021894-lq8yr710 278 41 of of IN cord-021894-lq8yr710 278 42 inhaled inhale VBN cord-021894-lq8yr710 278 43 epinephrine epinephrine NN cord-021894-lq8yr710 278 44 in in IN cord-021894-lq8yr710 278 45 children child NNS cord-021894-lq8yr710 278 46 with with IN cord-021894-lq8yr710 278 47 acute acute JJ cord-021894-lq8yr710 278 48 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 278 49 : : : cord-021894-lq8yr710 278 50 follow follow VB cord-021894-lq8yr710 278 51 - - HYPH cord-021894-lq8yr710 278 52 up up NN cord-021894-lq8yr710 278 53 from from IN cord-021894-lq8yr710 278 54 the the DT cord-021894-lq8yr710 278 55 randomised randomised JJ cord-021894-lq8yr710 278 56 , , , cord-021894-lq8yr710 278 57 controlled control VBN cord-021894-lq8yr710 278 58 , , , cord-021894-lq8yr710 278 59 double double JJ cord-021894-lq8yr710 278 60 - - HYPH cord-021894-lq8yr710 278 61 blind blind JJ cord-021894-lq8yr710 278 62 , , , cord-021894-lq8yr710 278 63 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 278 64 ALL all DT cord-021894-lq8yr710 278 65 trial trial NN cord-021894-lq8yr710 278 66 Nebulized Nebulized NNP cord-021894-lq8yr710 278 67 hypertonic hypertonic JJ cord-021894-lq8yr710 278 68 saline saline NN cord-021894-lq8yr710 278 69 for for IN cord-021894-lq8yr710 278 70 acute acute JJ cord-021894-lq8yr710 278 71 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 278 72 : : : cord-021894-lq8yr710 278 73 a a DT cord-021894-lq8yr710 278 74 systematic systematic JJ cord-021894-lq8yr710 278 75 review review NN cord-021894-lq8yr710 278 76 3 3 CD cord-021894-lq8yr710 278 77 % % NN cord-021894-lq8yr710 278 78 Hypertonic Hypertonic NNP cord-021894-lq8yr710 278 79 saline saline NN cord-021894-lq8yr710 278 80 versus versus IN cord-021894-lq8yr710 278 81 normal normal JJ cord-021894-lq8yr710 278 82 saline saline NN cord-021894-lq8yr710 278 83 in in IN cord-021894-lq8yr710 278 84 inpatient inpatient JJ cord-021894-lq8yr710 278 85 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 278 86 : : : cord-021894-lq8yr710 279 1 a a DT cord-021894-lq8yr710 279 2 randomized randomized JJ cord-021894-lq8yr710 279 3 controlled control VBN cord-021894-lq8yr710 279 4 trial trial NN cord-021894-lq8yr710 279 5 Nasal nasal NN cord-021894-lq8yr710 279 6 lavage lavage NN cord-021894-lq8yr710 279 7 leukotrienes leukotriene NNS cord-021894-lq8yr710 279 8 in in IN cord-021894-lq8yr710 279 9 infants infant NNS cord-021894-lq8yr710 279 10 with with IN cord-021894-lq8yr710 279 11 RSV RSV NNP cord-021894-lq8yr710 279 12 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 279 13 Serum serum NN cord-021894-lq8yr710 279 14 cathelicidin cathelicidin NN cord-021894-lq8yr710 279 15 level level NN cord-021894-lq8yr710 279 16 is be VBZ cord-021894-lq8yr710 279 17 associated associate VBN cord-021894-lq8yr710 279 18 with with IN cord-021894-lq8yr710 279 19 viral viral JJ cord-021894-lq8yr710 279 20 etiology etiology NN cord-021894-lq8yr710 279 21 and and CC cord-021894-lq8yr710 279 22 severity severity NN cord-021894-lq8yr710 279 23 of of IN cord-021894-lq8yr710 279 24 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 279 25 Lactate lactate NN cord-021894-lq8yr710 279 26 dehydrogenase dehydrogenase NN cord-021894-lq8yr710 279 27 and and CC cord-021894-lq8yr710 279 28 caspase caspase NN cord-021894-lq8yr710 279 29 activity activity NN cord-021894-lq8yr710 279 30 in in IN cord-021894-lq8yr710 279 31 nasopharyngeal nasopharyngeal JJ cord-021894-lq8yr710 279 32 secretions secretion NNS cord-021894-lq8yr710 279 33 are be VBP cord-021894-lq8yr710 279 34 predictors predictor NNS cord-021894-lq8yr710 279 35 of of IN cord-021894-lq8yr710 279 36 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 279 37 severity severity NN cord-021894-lq8yr710 279 38 . . . cord-021894-lq8yr710 280 1 Influenza Influenza NNP cord-021894-lq8yr710 280 2 Other other JJ cord-021894-lq8yr710 280 3 Respir Respir NNP cord-021894-lq8yr710 280 4 Viruses virus NNS cord-021894-lq8yr710 281 1 Interleukin-15 interleukin-15 PRP cord-021894-lq8yr710 281 2 is be VBZ cord-021894-lq8yr710 281 3 associated associate VBN cord-021894-lq8yr710 281 4 with with IN cord-021894-lq8yr710 281 5 disease disease NN cord-021894-lq8yr710 281 6 severity severity NN cord-021894-lq8yr710 281 7 in in IN cord-021894-lq8yr710 281 8 viral viral JJ cord-021894-lq8yr710 281 9 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 281 10 A a DT cord-021894-lq8yr710 281 11 robust robust JJ cord-021894-lq8yr710 281 12 cytokine cytokine NN cord-021894-lq8yr710 281 13 and and CC cord-021894-lq8yr710 281 14 chemokine chemokine NN cord-021894-lq8yr710 281 15 response response NN cord-021894-lq8yr710 281 16 in in IN cord-021894-lq8yr710 281 17 nasopharyngeal nasopharyngeal JJ cord-021894-lq8yr710 281 18 secretions secretion NNS cord-021894-lq8yr710 281 19 is be VBZ cord-021894-lq8yr710 281 20 associated associate VBN cord-021894-lq8yr710 281 21 with with IN cord-021894-lq8yr710 281 22 decreased decrease VBN cord-021894-lq8yr710 281 23 severity severity NN cord-021894-lq8yr710 281 24 in in IN cord-021894-lq8yr710 281 25 children child NNS cord-021894-lq8yr710 281 26 with with IN cord-021894-lq8yr710 281 27 physician physician NN cord-021894-lq8yr710 281 28 diagnosed diagnose VBN cord-021894-lq8yr710 281 29 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 281 30 Nasopharyngeal Nasopharyngeal NNP cord-021894-lq8yr710 281 31 bacterial bacterial JJ cord-021894-lq8yr710 281 32 burden burden NN cord-021894-lq8yr710 281 33 and and CC cord-021894-lq8yr710 281 34 antibiotics antibiotic NNS cord-021894-lq8yr710 281 35 : : : cord-021894-lq8yr710 281 36 influence influence NN cord-021894-lq8yr710 281 37 on on IN cord-021894-lq8yr710 281 38 inflammatory inflammatory JJ cord-021894-lq8yr710 281 39 markers marker NNS cord-021894-lq8yr710 281 40 and and CC cord-021894-lq8yr710 281 41 disease disease NN cord-021894-lq8yr710 281 42 severity severity NN cord-021894-lq8yr710 281 43 in in IN cord-021894-lq8yr710 281 44 infants infant NNS cord-021894-lq8yr710 281 45 with with IN cord-021894-lq8yr710 281 46 respiratory respiratory JJ cord-021894-lq8yr710 281 47 syncytial syncytial JJ cord-021894-lq8yr710 281 48 virus virus NN cord-021894-lq8yr710 281 49 bronchiolitis bronchioliti VBN cord-021894-lq8yr710 281 50 North North NNP cord-021894-lq8yr710 281 51 Ryde Ryde NNP cord-021894-lq8yr710 281 52 : : : cord-021894-lq8yr710 281 53 NSW NSW NNP cord-021894-lq8yr710 281 54 Ministry Ministry NNP cord-021894-lq8yr710 281 55 of of IN cord-021894-lq8yr710 281 56 Health Health NNP cord-021894-lq8yr710 281 57 Virus Virus NNP cord-021894-lq8yr710 281 58 type type NN cord-021894-lq8yr710 281 59 and and CC cord-021894-lq8yr710 281 60 genomic genomic JJ cord-021894-lq8yr710 281 61 load load NN cord-021894-lq8yr710 281 62 in in IN cord-021894-lq8yr710 281 63 acute acute JJ cord-021894-lq8yr710 281 64 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 281 65 : : : cord-021894-lq8yr710 281 66 severity severity NN cord-021894-lq8yr710 281 67 and and CC cord-021894-lq8yr710 281 68 treatment treatment NN cord-021894-lq8yr710 281 69 response response NN cord-021894-lq8yr710 281 70 with with IN cord-021894-lq8yr710 281 71 inhaled inhale VBN cord-021894-lq8yr710 281 72 adrenaline adrenaline NN cord-021894-lq8yr710 282 1 The the DT cord-021894-lq8yr710 282 2 G g NN cord-021894-lq8yr710 282 3 glycoprotein glycoprotein NN cord-021894-lq8yr710 282 4 of of IN cord-021894-lq8yr710 282 5 respiratory respiratory JJ cord-021894-lq8yr710 282 6 syncytial syncytial JJ cord-021894-lq8yr710 282 7 virus virus NN cord-021894-lq8yr710 282 8 depresses depress VBZ cord-021894-lq8yr710 282 9 respiratory respiratory JJ cord-021894-lq8yr710 282 10 rates rate NNS cord-021894-lq8yr710 282 11 through through IN cord-021894-lq8yr710 282 12 the the DT cord-021894-lq8yr710 282 13 CX3C CX3C NNS cord-021894-lq8yr710 282 14 motif motif NN cord-021894-lq8yr710 282 15 and and CC cord-021894-lq8yr710 282 16 substance substance NN cord-021894-lq8yr710 282 17 P p NN cord-021894-lq8yr710 282 18 Risk risk NN cord-021894-lq8yr710 282 19 factors factor NNS cord-021894-lq8yr710 282 20 for for IN cord-021894-lq8yr710 282 21 requiring require VBG cord-021894-lq8yr710 282 22 intensive intensive JJ cord-021894-lq8yr710 282 23 care care NN cord-021894-lq8yr710 282 24 among among IN cord-021894-lq8yr710 282 25 children child NNS cord-021894-lq8yr710 282 26 admitted admit VBN cord-021894-lq8yr710 282 27 to to TO cord-021894-lq8yr710 282 28 ward ward VB cord-021894-lq8yr710 282 29 with with IN cord-021894-lq8yr710 282 30 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 282 31 Effect Effect NNP cord-021894-lq8yr710 282 32 of of IN cord-021894-lq8yr710 282 33 oxygen oxygen NN cord-021894-lq8yr710 282 34 supplementation supplementation NN cord-021894-lq8yr710 282 35 on on IN cord-021894-lq8yr710 282 36 length length NN cord-021894-lq8yr710 282 37 of of IN cord-021894-lq8yr710 282 38 stay stay NN cord-021894-lq8yr710 282 39 for for IN cord-021894-lq8yr710 282 40 infants infant NNS cord-021894-lq8yr710 282 41 hospitalized hospitalize VBN cord-021894-lq8yr710 282 42 with with IN cord-021894-lq8yr710 282 43 acute acute JJ cord-021894-lq8yr710 282 44 viral viral JJ cord-021894-lq8yr710 282 45 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 282 46 Hospital Hospital NNP cord-021894-lq8yr710 282 47 course course NN cord-021894-lq8yr710 282 48 and and CC cord-021894-lq8yr710 282 49 discharge discharge NN cord-021894-lq8yr710 282 50 criteria criterion NNS cord-021894-lq8yr710 282 51 for for IN cord-021894-lq8yr710 282 52 children child NNS cord-021894-lq8yr710 282 53 hospitalized hospitalize VBN cord-021894-lq8yr710 282 54 with with IN cord-021894-lq8yr710 282 55 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 282 56 Inter Inter NNP cord-021894-lq8yr710 282 57 - - JJ cord-021894-lq8yr710 282 58 observer observer NN cord-021894-lq8yr710 282 59 agreement agreement NN cord-021894-lq8yr710 282 60 between between IN cord-021894-lq8yr710 282 61 physicians physician NNS cord-021894-lq8yr710 282 62 , , , cord-021894-lq8yr710 282 63 nurses nurse NNS cord-021894-lq8yr710 282 64 , , , cord-021894-lq8yr710 282 65 and and CC cord-021894-lq8yr710 282 66 respiratory respiratory JJ cord-021894-lq8yr710 282 67 therapists therapist NNS cord-021894-lq8yr710 282 68 for for IN cord-021894-lq8yr710 282 69 respiratory respiratory JJ cord-021894-lq8yr710 282 70 clinical clinical JJ cord-021894-lq8yr710 282 71 evaluation evaluation NN cord-021894-lq8yr710 282 72 in in IN cord-021894-lq8yr710 282 73 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 282 74 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 282 75 : : : cord-021894-lq8yr710 282 76 recommendations recommendation NNS cord-021894-lq8yr710 282 77 for for IN cord-021894-lq8yr710 282 78 diagnosis diagnosis NN cord-021894-lq8yr710 282 79 , , , cord-021894-lq8yr710 282 80 monitoring monitoring NN cord-021894-lq8yr710 282 81 and and CC cord-021894-lq8yr710 282 82 management management NN cord-021894-lq8yr710 282 83 of of IN cord-021894-lq8yr710 282 84 children child NNS cord-021894-lq8yr710 282 85 one one CD cord-021894-lq8yr710 282 86 to to TO cord-021894-lq8yr710 282 87 24 24 CD cord-021894-lq8yr710 282 88 months month NNS cord-021894-lq8yr710 282 89 of of IN cord-021894-lq8yr710 282 90 age age NN cord-021894-lq8yr710 282 91 Is be VBZ cord-021894-lq8yr710 282 92 nasal nasal NN cord-021894-lq8yr710 282 93 suctioning suctioning NN cord-021894-lq8yr710 282 94 warranted warrant VBN cord-021894-lq8yr710 282 95 before before IN cord-021894-lq8yr710 282 96 measuring measure VBG cord-021894-lq8yr710 282 97 O2 o2 NN cord-021894-lq8yr710 282 98 saturation saturation NN cord-021894-lq8yr710 282 99 in in IN cord-021894-lq8yr710 282 100 infants infant NNS cord-021894-lq8yr710 282 101 with with IN cord-021894-lq8yr710 282 102 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 282 103 ? ? . cord-021894-lq8yr710 283 1 Wheezing wheeze VBG cord-021894-lq8yr710 283 2 in in IN cord-021894-lq8yr710 283 3 infants infant NNS cord-021894-lq8yr710 283 4 : : : cord-021894-lq8yr710 283 5 the the DT cord-021894-lq8yr710 283 6 response response NN cord-021894-lq8yr710 283 7 to to IN cord-021894-lq8yr710 283 8 epinephrine epinephrine NN cord-021894-lq8yr710 283 9 Measuring measure VBG cord-021894-lq8yr710 283 10 clinical clinical JJ cord-021894-lq8yr710 283 11 severity severity NN cord-021894-lq8yr710 283 12 in in IN cord-021894-lq8yr710 283 13 infants infant NNS cord-021894-lq8yr710 283 14 with with IN cord-021894-lq8yr710 283 15 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 283 16 Bacteremia Bacteremia NNP cord-021894-lq8yr710 283 17 in in IN cord-021894-lq8yr710 283 18 children child NNS cord-021894-lq8yr710 283 19 hospitalized hospitalize VBN cord-021894-lq8yr710 283 20 with with IN cord-021894-lq8yr710 283 21 respiratory respiratory JJ cord-021894-lq8yr710 283 22 syncytial syncytial JJ cord-021894-lq8yr710 283 23 virus virus NN cord-021894-lq8yr710 283 24 infection infection NN cord-021894-lq8yr710 283 25 WHO who WP cord-021894-lq8yr710 283 26 consultation consultation NN cord-021894-lq8yr710 283 27 on on IN cord-021894-lq8yr710 283 28 Respiratory Respiratory NNP cord-021894-lq8yr710 283 29 Syncytial Syncytial NNP cord-021894-lq8yr710 283 30 Virus Virus NNP cord-021894-lq8yr710 283 31 Vaccine Vaccine NNP cord-021894-lq8yr710 283 32 Development Development NNP cord-021894-lq8yr710 283 33 Report Report NNP cord-021894-lq8yr710 283 34 from from IN cord-021894-lq8yr710 283 35 a a DT cord-021894-lq8yr710 283 36 World World NNP cord-021894-lq8yr710 283 37 Health Health NNP cord-021894-lq8yr710 283 38 Organization Organization NNP cord-021894-lq8yr710 283 39 Meeting Meeting NNP cord-021894-lq8yr710 283 40 held hold VBD cord-021894-lq8yr710 283 41 on on IN cord-021894-lq8yr710 283 42 23 23 CD cord-021894-lq8yr710 283 43 - - SYM cord-021894-lq8yr710 283 44 24 24 CD cord-021894-lq8yr710 283 45 Effect effect NN cord-021894-lq8yr710 283 46 of of IN cord-021894-lq8yr710 283 47 oxygen oxygen NN cord-021894-lq8yr710 283 48 desaturations desaturation NNS cord-021894-lq8yr710 283 49 on on IN cord-021894-lq8yr710 283 50 subsequent subsequent JJ cord-021894-lq8yr710 283 51 medical medical JJ cord-021894-lq8yr710 283 52 visits visit NNS cord-021894-lq8yr710 283 53 in in IN cord-021894-lq8yr710 283 54 infants infant NNS cord-021894-lq8yr710 283 55 discharged discharge VBN cord-021894-lq8yr710 283 56 from from IN cord-021894-lq8yr710 283 57 the the DT cord-021894-lq8yr710 283 58 emergency emergency NN cord-021894-lq8yr710 283 59 department department NN cord-021894-lq8yr710 283 60 with with IN cord-021894-lq8yr710 283 61 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 283 62 Effect Effect NNP cord-021894-lq8yr710 283 63 of of IN cord-021894-lq8yr710 283 64 oximetry oximetry NN cord-021894-lq8yr710 283 65 on on IN cord-021894-lq8yr710 283 66 hospitalization hospitalization NN cord-021894-lq8yr710 283 67 in in IN cord-021894-lq8yr710 283 68 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 283 69 : : : cord-021894-lq8yr710 284 1 a a DT cord-021894-lq8yr710 284 2 randomized randomized JJ cord-021894-lq8yr710 284 3 clinical clinical JJ cord-021894-lq8yr710 284 4 trial trial NN cord-021894-lq8yr710 284 5 Variation variation NN cord-021894-lq8yr710 284 6 in in IN cord-021894-lq8yr710 284 7 inpatient inpatient JJ cord-021894-lq8yr710 284 8 diagnostic diagnostic JJ cord-021894-lq8yr710 284 9 testing testing NN cord-021894-lq8yr710 284 10 and and CC cord-021894-lq8yr710 284 11 management management NN cord-021894-lq8yr710 284 12 of of IN cord-021894-lq8yr710 284 13 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 284 14 Predictors Predictors NNP cord-021894-lq8yr710 284 15 of of IN cord-021894-lq8yr710 284 16 airspace airspace NN cord-021894-lq8yr710 284 17 disease disease NN cord-021894-lq8yr710 284 18 on on IN cord-021894-lq8yr710 284 19 chest chest NN cord-021894-lq8yr710 284 20 x x NN cord-021894-lq8yr710 284 21 - - NN cord-021894-lq8yr710 284 22 ray ray NN cord-021894-lq8yr710 284 23 in in IN cord-021894-lq8yr710 284 24 emergency emergency NN cord-021894-lq8yr710 284 25 department department NN cord-021894-lq8yr710 284 26 patients patient NNS cord-021894-lq8yr710 284 27 with with IN cord-021894-lq8yr710 284 28 clinical clinical JJ cord-021894-lq8yr710 284 29 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 284 30 : : : cord-021894-lq8yr710 284 31 a a DT cord-021894-lq8yr710 284 32 systematic systematic JJ cord-021894-lq8yr710 284 33 review review NN cord-021894-lq8yr710 284 34 and and CC cord-021894-lq8yr710 284 35 meta meta NNP cord-021894-lq8yr710 284 36 - - HYPH cord-021894-lq8yr710 284 37 analysis analysis NN cord-021894-lq8yr710 284 38 Assessing assess VBG cord-021894-lq8yr710 284 39 the the DT cord-021894-lq8yr710 284 40 utility utility NN cord-021894-lq8yr710 284 41 of of IN cord-021894-lq8yr710 284 42 urine urine NN cord-021894-lq8yr710 284 43 testing testing NN cord-021894-lq8yr710 284 44 in in IN cord-021894-lq8yr710 284 45 febrile febrile JJ cord-021894-lq8yr710 284 46 infants infant NNS cord-021894-lq8yr710 284 47 aged age VBN cord-021894-lq8yr710 284 48 2 2 CD cord-021894-lq8yr710 284 49 to to TO cord-021894-lq8yr710 284 50 12 12 CD cord-021894-lq8yr710 284 51 months month NNS cord-021894-lq8yr710 284 52 with with IN cord-021894-lq8yr710 284 53 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 284 54 Respiratory respiratory JJ cord-021894-lq8yr710 284 55 syncytial syncytial JJ cord-021894-lq8yr710 284 56 virus virus NN cord-021894-lq8yr710 284 57 ( ( -LRB- cord-021894-lq8yr710 284 58 RSV RSV NNP cord-021894-lq8yr710 284 59 ) ) -RRB- cord-021894-lq8yr710 284 60 immune immune JJ cord-021894-lq8yr710 284 61 globulin globulin NN cord-021894-lq8yr710 284 62 intravenous intravenous JJ cord-021894-lq8yr710 284 63 therapy therapy NN cord-021894-lq8yr710 284 64 for for IN cord-021894-lq8yr710 284 65 RSV RSV NNP cord-021894-lq8yr710 284 66 lower low JJR cord-021894-lq8yr710 284 67 respiratory respiratory JJ cord-021894-lq8yr710 284 68 tract tract NN cord-021894-lq8yr710 284 69 infection infection NN cord-021894-lq8yr710 284 70 in in IN cord-021894-lq8yr710 284 71 infants infant NNS cord-021894-lq8yr710 284 72 and and CC cord-021894-lq8yr710 284 73 young young JJ cord-021894-lq8yr710 284 74 children child NNS cord-021894-lq8yr710 284 75 at at IN cord-021894-lq8yr710 284 76 high high JJ cord-021894-lq8yr710 284 77 risk risk NN cord-021894-lq8yr710 284 78 for for IN cord-021894-lq8yr710 284 79 severe severe JJ cord-021894-lq8yr710 284 80 RSV RSV NNP cord-021894-lq8yr710 284 81 infections infection NNS cord-021894-lq8yr710 284 82 : : : cord-021894-lq8yr710 284 83 respiratory respiratory JJ cord-021894-lq8yr710 284 84 syncytial syncytial JJ cord-021894-lq8yr710 284 85 virus virus NN cord-021894-lq8yr710 284 86 immune immune JJ cord-021894-lq8yr710 284 87 globulin globulin NN cord-021894-lq8yr710 284 88 study study NN cord-021894-lq8yr710 284 89 group group NN cord-021894-lq8yr710 284 90 Reduction reduction NN cord-021894-lq8yr710 284 91 of of IN cord-021894-lq8yr710 284 92 respiratory respiratory JJ cord-021894-lq8yr710 284 93 syncytial syncytial JJ cord-021894-lq8yr710 284 94 virus virus NN cord-021894-lq8yr710 284 95 hospitalization hospitalization NN cord-021894-lq8yr710 284 96 among among IN cord-021894-lq8yr710 284 97 premature premature JJ cord-021894-lq8yr710 284 98 infants infant NNS cord-021894-lq8yr710 284 99 and and CC cord-021894-lq8yr710 284 100 infants infant NNS cord-021894-lq8yr710 284 101 with with IN cord-021894-lq8yr710 284 102 bronchopulmonary bronchopulmonary JJ cord-021894-lq8yr710 284 103 dysplasia dysplasia NN cord-021894-lq8yr710 284 104 using use VBG cord-021894-lq8yr710 284 105 respiratory respiratory JJ cord-021894-lq8yr710 284 106 syncytial syncytial JJ cord-021894-lq8yr710 284 107 virus virus NN cord-021894-lq8yr710 284 108 immune immune JJ cord-021894-lq8yr710 284 109 globulin globulin NN cord-021894-lq8yr710 284 110 prophylaxis prophylaxis NN cord-021894-lq8yr710 284 111 Palivizumab Palivizumab NNP cord-021894-lq8yr710 284 112 , , , cord-021894-lq8yr710 284 113 a a DT cord-021894-lq8yr710 284 114 humanized humanize VBN cord-021894-lq8yr710 284 115 respiratory respiratory JJ cord-021894-lq8yr710 284 116 syncytial syncytial JJ cord-021894-lq8yr710 284 117 virus virus NN cord-021894-lq8yr710 284 118 monoclonal monoclonal JJ cord-021894-lq8yr710 284 119 antibody antibody NN cord-021894-lq8yr710 284 120 , , , cord-021894-lq8yr710 284 121 reduces reduce VBZ cord-021894-lq8yr710 284 122 hospitalization hospitalization NN cord-021894-lq8yr710 284 123 from from IN cord-021894-lq8yr710 284 124 respiratory respiratory JJ cord-021894-lq8yr710 284 125 syncytial syncytial JJ cord-021894-lq8yr710 284 126 virus virus NN cord-021894-lq8yr710 284 127 infection infection NN cord-021894-lq8yr710 284 128 in in IN cord-021894-lq8yr710 284 129 high high JJ cord-021894-lq8yr710 284 130 - - HYPH cord-021894-lq8yr710 284 131 risk risk NN cord-021894-lq8yr710 284 132 infants infant NNS cord-021894-lq8yr710 285 1 Lower low JJR cord-021894-lq8yr710 285 2 respiratory respiratory JJ cord-021894-lq8yr710 285 3 tract tract NN cord-021894-lq8yr710 285 4 infection infection NN cord-021894-lq8yr710 285 5 caused cause VBN cord-021894-lq8yr710 285 6 by by IN cord-021894-lq8yr710 285 7 respiratory respiratory JJ cord-021894-lq8yr710 285 8 syncytial syncytial JJ cord-021894-lq8yr710 285 9 virus virus NN cord-021894-lq8yr710 285 10 : : : cord-021894-lq8yr710 286 1 current current JJ cord-021894-lq8yr710 286 2 management management NN cord-021894-lq8yr710 286 3 and and CC cord-021894-lq8yr710 286 4 new new JJ cord-021894-lq8yr710 286 5 therapeutics therapeutic NNS cord-021894-lq8yr710 286 6 Epinephrine epinephrine NN cord-021894-lq8yr710 286 7 and and CC cord-021894-lq8yr710 286 8 dexamethasone dexamethasone NN cord-021894-lq8yr710 286 9 in in IN cord-021894-lq8yr710 286 10 children child NNS cord-021894-lq8yr710 286 11 with with IN cord-021894-lq8yr710 286 12 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 286 13 Decreased decrease VBD cord-021894-lq8yr710 286 14 lung lung NN cord-021894-lq8yr710 286 15 function function NN cord-021894-lq8yr710 286 16 precedes precede VBZ cord-021894-lq8yr710 286 17 severe severe JJ cord-021894-lq8yr710 286 18 respiratory respiratory JJ cord-021894-lq8yr710 286 19 syncytial syncytial JJ cord-021894-lq8yr710 286 20 virus virus NN cord-021894-lq8yr710 286 21 infection infection NN cord-021894-lq8yr710 286 22 and and CC cord-021894-lq8yr710 286 23 post post JJ cord-021894-lq8yr710 286 24 - - JJ cord-021894-lq8yr710 286 25 respiratory respiratory JJ cord-021894-lq8yr710 286 26 syncytial syncytial JJ cord-021894-lq8yr710 286 27 virus virus NN cord-021894-lq8yr710 286 28 wheeze wheeze NN cord-021894-lq8yr710 286 29 in in IN cord-021894-lq8yr710 286 30 term term NN cord-021894-lq8yr710 286 31 infants infant NNS cord-021894-lq8yr710 286 32 Clinical clinical JJ cord-021894-lq8yr710 286 33 prediction prediction NN cord-021894-lq8yr710 286 34 rule rule NN cord-021894-lq8yr710 286 35 for for IN cord-021894-lq8yr710 286 36 RSV RSV NNP cord-021894-lq8yr710 286 37 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 286 38 in in IN cord-021894-lq8yr710 286 39 healthy healthy JJ cord-021894-lq8yr710 286 40 newborns newborn NNS cord-021894-lq8yr710 286 41 : : : cord-021894-lq8yr710 286 42 prognostic prognostic JJ cord-021894-lq8yr710 286 43 birth birth NN cord-021894-lq8yr710 286 44 cohort cohort NN cord-021894-lq8yr710 286 45 study study NN cord-021894-lq8yr710 286 46 Study Study NNP cord-021894-lq8yr710 286 47 of of IN cord-021894-lq8yr710 286 48 montelukast montelukast NNP cord-021894-lq8yr710 286 49 for for IN cord-021894-lq8yr710 286 50 the the DT cord-021894-lq8yr710 286 51 treatment treatment NN cord-021894-lq8yr710 286 52 of of IN cord-021894-lq8yr710 286 53 respiratory respiratory JJ cord-021894-lq8yr710 286 54 symptoms symptom NNS cord-021894-lq8yr710 286 55 of of IN cord-021894-lq8yr710 286 56 post post JJ cord-021894-lq8yr710 286 57 - - JJ cord-021894-lq8yr710 286 58 respiratory respiratory JJ cord-021894-lq8yr710 286 59 syncytial syncytial JJ cord-021894-lq8yr710 286 60 virus virus NN cord-021894-lq8yr710 286 61 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 286 62 in in IN cord-021894-lq8yr710 286 63 children child NNS cord-021894-lq8yr710 286 64 Randomised randomised JJ cord-021894-lq8yr710 286 65 placebo placebo NN cord-021894-lq8yr710 286 66 controlled control VBN cord-021894-lq8yr710 286 67 trial trial NN cord-021894-lq8yr710 286 68 of of IN cord-021894-lq8yr710 286 69 nebulised nebulised JJ cord-021894-lq8yr710 286 70 corticosteroids corticosteroid NNS cord-021894-lq8yr710 286 71 in in IN cord-021894-lq8yr710 286 72 acute acute JJ cord-021894-lq8yr710 286 73 respiratory respiratory JJ cord-021894-lq8yr710 286 74 syncytial syncytial JJ cord-021894-lq8yr710 286 75 viral viral JJ cord-021894-lq8yr710 286 76 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 286 77 on on IN cord-021894-lq8yr710 286 78 behalf behalf NN cord-021894-lq8yr710 286 79 of of IN cord-021894-lq8yr710 286 80 the the DT cord-021894-lq8yr710 286 81 RSVCSG RSVCSG NNP cord-021894-lq8yr710 286 82 . . . cord-021894-lq8yr710 287 1 Lack lack NN cord-021894-lq8yr710 287 2 of of IN cord-021894-lq8yr710 287 3 long long JJ cord-021894-lq8yr710 287 4 term term NN cord-021894-lq8yr710 287 5 effects effect NNS cord-021894-lq8yr710 287 6 of of IN cord-021894-lq8yr710 287 7 high high JJ cord-021894-lq8yr710 287 8 dose dose NN cord-021894-lq8yr710 287 9 inhaled inhale VBN cord-021894-lq8yr710 287 10 beclomethasone beclomethasone NN cord-021894-lq8yr710 287 11 for for IN cord-021894-lq8yr710 287 12 RSV RSV NNP cord-021894-lq8yr710 287 13 bronchiolitis bronchiolitis NNP cord-021894-lq8yr710 287 14 - - : cord-021894-lq8yr710 287 15 a a DT cord-021894-lq8yr710 287 16 randomized randomized JJ cord-021894-lq8yr710 287 17 placebo placebo NN cord-021894-lq8yr710 287 18 - - HYPH cord-021894-lq8yr710 287 19 controlled control VBN cord-021894-lq8yr710 287 20 trial trial NN cord-021894-lq8yr710 287 21 Respiratory respiratory JJ cord-021894-lq8yr710 287 22 syncytial syncytial JJ cord-021894-lq8yr710 287 23 virus virus NN cord-021894-lq8yr710 287 24 and and CC cord-021894-lq8yr710 287 25 recurrent recurrent JJ cord-021894-lq8yr710 287 26 wheeze wheeze NN cord-021894-lq8yr710 287 27 Randomized randomized JJ cord-021894-lq8yr710 287 28 trial trial NN cord-021894-lq8yr710 287 29 to to TO cord-021894-lq8yr710 287 30 evaluate evaluate VB cord-021894-lq8yr710 287 31 azithromycin azithromycin NNP cord-021894-lq8yr710 287 32 's 's POS cord-021894-lq8yr710 287 33 effects effect NNS cord-021894-lq8yr710 287 34 on on IN cord-021894-lq8yr710 287 35 serum serum NN cord-021894-lq8yr710 287 36 and and CC cord-021894-lq8yr710 287 37 upper upper JJ cord-021894-lq8yr710 287 38 airway airway NN cord-021894-lq8yr710 287 39 IL-8 il-8 NN cord-021894-lq8yr710 287 40 levels level NNS cord-021894-lq8yr710 287 41 and and CC cord-021894-lq8yr710 287 42 recurrent recurrent JJ cord-021894-lq8yr710 287 43 wheezing wheezing NN cord-021894-lq8yr710 287 44 in in IN cord-021894-lq8yr710 287 45 infants infant NNS cord-021894-lq8yr710 287 46 with with IN cord-021894-lq8yr710 287 47 respiratory respiratory JJ cord-021894-lq8yr710 287 48 syncytial syncytial JJ cord-021894-lq8yr710 287 49 virus virus NN cord-021894-lq8yr710 287 50 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 287 51 Severe severe JJ cord-021894-lq8yr710 287 52 respiratory respiratory JJ cord-021894-lq8yr710 287 53 syncytial syncytial JJ cord-021894-lq8yr710 287 54 virus virus NN cord-021894-lq8yr710 287 55 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 287 56 in in IN cord-021894-lq8yr710 287 57 infancy infancy NN cord-021894-lq8yr710 287 58 and and CC cord-021894-lq8yr710 287 59 asthma asthma NN cord-021894-lq8yr710 287 60 and and CC cord-021894-lq8yr710 287 61 allergy allergy NN cord-021894-lq8yr710 287 62 at at IN cord-021894-lq8yr710 287 63 age age NN cord-021894-lq8yr710 287 64 13 13 CD cord-021894-lq8yr710 287 65 Asthma Asthma NNS cord-021894-lq8yr710 287 66 and and CC cord-021894-lq8yr710 287 67 allergy allergy NN cord-021894-lq8yr710 287 68 patterns pattern NNS cord-021894-lq8yr710 287 69 over over IN cord-021894-lq8yr710 287 70 18 18 CD cord-021894-lq8yr710 287 71 years year NNS cord-021894-lq8yr710 287 72 after after IN cord-021894-lq8yr710 287 73 severe severe JJ cord-021894-lq8yr710 287 74 RSV RSV NNP cord-021894-lq8yr710 287 75 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 287 76 in in IN cord-021894-lq8yr710 287 77 the the DT cord-021894-lq8yr710 287 78 first first JJ cord-021894-lq8yr710 287 79 year year NN cord-021894-lq8yr710 287 80 of of IN cord-021894-lq8yr710 287 81 life life NN cord-021894-lq8yr710 288 1 Nebulized nebulized JJ cord-021894-lq8yr710 288 2 hypertonic hypertonic JJ cord-021894-lq8yr710 288 3 saline saline NN cord-021894-lq8yr710 288 4 for for IN cord-021894-lq8yr710 288 5 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 288 6 : : : cord-021894-lq8yr710 288 7 a a DT cord-021894-lq8yr710 288 8 randomized randomized JJ cord-021894-lq8yr710 288 9 clinical clinical JJ cord-021894-lq8yr710 288 10 trial trial NN cord-021894-lq8yr710 289 1 The the DT cord-021894-lq8yr710 289 2 effect effect NN cord-021894-lq8yr710 289 3 of of IN cord-021894-lq8yr710 289 4 3 3 CD cord-021894-lq8yr710 289 5 % % NN cord-021894-lq8yr710 289 6 and and CC cord-021894-lq8yr710 289 7 6 6 CD cord-021894-lq8yr710 289 8 % % NN cord-021894-lq8yr710 289 9 hypertonic hypertonic JJ cord-021894-lq8yr710 289 10 saline saline NN cord-021894-lq8yr710 289 11 in in IN cord-021894-lq8yr710 289 12 viral viral JJ cord-021894-lq8yr710 289 13 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 14 : : : cord-021894-lq8yr710 289 15 a a DT cord-021894-lq8yr710 289 16 randomised randomised JJ cord-021894-lq8yr710 289 17 controlled control VBN cord-021894-lq8yr710 289 18 trial trial NN cord-021894-lq8yr710 289 19 7 7 CD cord-021894-lq8yr710 289 20 % % NN cord-021894-lq8yr710 289 21 Hypertonic Hypertonic NNP cord-021894-lq8yr710 289 22 saline saline NN cord-021894-lq8yr710 289 23 in in IN cord-021894-lq8yr710 289 24 acute acute JJ cord-021894-lq8yr710 289 25 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 26 : : : cord-021894-lq8yr710 289 27 a a DT cord-021894-lq8yr710 289 28 randomized randomized JJ cord-021894-lq8yr710 289 29 controlled control VBN cord-021894-lq8yr710 289 30 trial trial NN cord-021894-lq8yr710 289 31 SABRE SABRE NNP cord-021894-lq8yr710 289 32 : : : cord-021894-lq8yr710 289 33 a a DT cord-021894-lq8yr710 289 34 multicentre multicentre NNP cord-021894-lq8yr710 289 35 randomised randomised JJ cord-021894-lq8yr710 289 36 control control NN cord-021894-lq8yr710 289 37 trial trial NN cord-021894-lq8yr710 289 38 of of IN cord-021894-lq8yr710 289 39 nebulised nebulised JJ cord-021894-lq8yr710 289 40 hypertonic hypertonic JJ cord-021894-lq8yr710 289 41 saline saline NN cord-021894-lq8yr710 289 42 in in IN cord-021894-lq8yr710 289 43 infants infant NNS cord-021894-lq8yr710 289 44 hospitalised hospitalise VBN cord-021894-lq8yr710 289 45 with with IN cord-021894-lq8yr710 289 46 acute acute JJ cord-021894-lq8yr710 289 47 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 48 High high JJ cord-021894-lq8yr710 289 49 - - HYPH cord-021894-lq8yr710 289 50 flow flow NN cord-021894-lq8yr710 289 51 nasal nasal NN cord-021894-lq8yr710 289 52 cannula cannula NN cord-021894-lq8yr710 289 53 oxygen oxygen NN cord-021894-lq8yr710 289 54 for for IN cord-021894-lq8yr710 289 55 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 56 in in IN cord-021894-lq8yr710 289 57 a a DT cord-021894-lq8yr710 289 58 pediatric pediatric JJ cord-021894-lq8yr710 289 59 ward ward NN cord-021894-lq8yr710 289 60 : : : cord-021894-lq8yr710 289 61 a a DT cord-021894-lq8yr710 289 62 pilot pilot NN cord-021894-lq8yr710 289 63 study study NN cord-021894-lq8yr710 289 64 CPAP cpap NN cord-021894-lq8yr710 289 65 and and CC cord-021894-lq8yr710 289 66 high high JJ cord-021894-lq8yr710 289 67 - - HYPH cord-021894-lq8yr710 289 68 flow flow NN cord-021894-lq8yr710 289 69 nasal nasal NN cord-021894-lq8yr710 289 70 cannula cannula NN cord-021894-lq8yr710 289 71 oxygen oxygen NN cord-021894-lq8yr710 289 72 in in IN cord-021894-lq8yr710 289 73 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 74 High high JJ cord-021894-lq8yr710 289 75 - - HYPH cord-021894-lq8yr710 289 76 flow flow NN cord-021894-lq8yr710 289 77 warm warm JJ cord-021894-lq8yr710 289 78 humidified humidify VBN cord-021894-lq8yr710 289 79 oxygen oxygen NN cord-021894-lq8yr710 289 80 versus versus IN cord-021894-lq8yr710 289 81 low low JJ cord-021894-lq8yr710 289 82 - - HYPH cord-021894-lq8yr710 289 83 flow flow NN cord-021894-lq8yr710 289 84 nasal nasal NN cord-021894-lq8yr710 289 85 cannula cannula NN cord-021894-lq8yr710 289 86 oxygen oxygen NN cord-021894-lq8yr710 289 87 for for IN cord-021894-lq8yr710 289 88 moderate moderate JJ cord-021894-lq8yr710 289 89 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 90 ( ( -LRB- cord-021894-lq8yr710 289 91 HFWHO HFWHO NNP cord-021894-lq8yr710 289 92 RCT RCT NNP cord-021894-lq8yr710 289 93 ) ) -RRB- cord-021894-lq8yr710 289 94 : : : cord-021894-lq8yr710 289 95 an an DT cord-021894-lq8yr710 289 96 open open JJ cord-021894-lq8yr710 289 97 , , , cord-021894-lq8yr710 289 98 phase phase NN cord-021894-lq8yr710 289 99 4 4 CD cord-021894-lq8yr710 289 100 , , , cord-021894-lq8yr710 289 101 randomised randomise VBN cord-021894-lq8yr710 289 102 controlled control VBN cord-021894-lq8yr710 289 103 trial trial NN cord-021894-lq8yr710 289 104 Early early JJ cord-021894-lq8yr710 289 105 high high JJ cord-021894-lq8yr710 289 106 flow flow NN cord-021894-lq8yr710 289 107 nasal nasal NN cord-021894-lq8yr710 289 108 cannula cannula NN cord-021894-lq8yr710 289 109 therapy therapy NN cord-021894-lq8yr710 289 110 in in IN cord-021894-lq8yr710 289 111 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 289 112 , , , cord-021894-lq8yr710 289 113 a a DT cord-021894-lq8yr710 289 114 prospective prospective JJ cord-021894-lq8yr710 289 115 randomised randomised JJ cord-021894-lq8yr710 289 116 control control NN cord-021894-lq8yr710 289 117 trial trial NN cord-021894-lq8yr710 289 118 ( ( -LRB- cord-021894-lq8yr710 289 119 protocol protocol NN cord-021894-lq8yr710 289 120 ) ) -RRB- cord-021894-lq8yr710 289 121 : : : cord-021894-lq8yr710 289 122 a a DT cord-021894-lq8yr710 289 123 paediatric paediatric JJ cord-021894-lq8yr710 289 124 acute acute JJ cord-021894-lq8yr710 289 125 respiratory respiratory JJ cord-021894-lq8yr710 289 126 intervention intervention NN cord-021894-lq8yr710 289 127 study study NN cord-021894-lq8yr710 289 128 ( ( -LRB- cord-021894-lq8yr710 289 129 PARIS PARIS NNP cord-021894-lq8yr710 289 130 ) ) -RRB- cord-021894-lq8yr710 290 1 Improved improve VBN cord-021894-lq8yr710 290 2 clinical clinical JJ cord-021894-lq8yr710 290 3 and and CC cord-021894-lq8yr710 290 4 economic economic JJ cord-021894-lq8yr710 290 5 outcomes outcome NNS cord-021894-lq8yr710 290 6 in in IN cord-021894-lq8yr710 290 7 severe severe JJ cord-021894-lq8yr710 290 8 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 290 9 with with IN cord-021894-lq8yr710 290 10 pre pre JJ cord-021894-lq8yr710 290 11 - - JJ cord-021894-lq8yr710 290 12 emptive emptive JJ cord-021894-lq8yr710 290 13 nCPAP ncpap NN cord-021894-lq8yr710 290 14 ventilatory ventilatory JJ cord-021894-lq8yr710 290 15 strategy strategy NN cord-021894-lq8yr710 291 1 Variability variability NN cord-021894-lq8yr710 291 2 of of IN cord-021894-lq8yr710 291 3 intensive intensive JJ cord-021894-lq8yr710 291 4 care care NN cord-021894-lq8yr710 291 5 management management NN cord-021894-lq8yr710 291 6 for for IN cord-021894-lq8yr710 291 7 children child NNS cord-021894-lq8yr710 291 8 with with IN cord-021894-lq8yr710 291 9 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 291 10 Mechanical mechanical JJ cord-021894-lq8yr710 291 11 ventilation ventilation NN cord-021894-lq8yr710 291 12 drives drive VBZ cord-021894-lq8yr710 291 13 inflammation inflammation NN cord-021894-lq8yr710 291 14 in in IN cord-021894-lq8yr710 291 15 severe severe JJ cord-021894-lq8yr710 291 16 viral viral JJ cord-021894-lq8yr710 291 17 bronchiolitis bronchiolitis NN cord-021894-lq8yr710 291 18 Bronchiolitis Bronchiolitis NNP cord-021894-lq8yr710 291 19 in in IN cord-021894-lq8yr710 291 20 Children Children NNP cord-021894-lq8yr710 291 21 ( ( -LRB- cord-021894-lq8yr710 291 22 SIGN sign NN cord-021894-lq8yr710 291 23 91 91 CD cord-021894-lq8yr710 291 24 ) ) -RRB- cord-021894-lq8yr710 291 25 . . . cord-021894-lq8yr710 292 1 NHS NHS NNP cord-021894-lq8yr710 292 2 Quality Quality NNP cord-021894-lq8yr710 292 3 Improvement improvement NN cord-021894-lq8yr710 292 4 : : : cord-021894-lq8yr710 293 1 Scotland Scotland NNP cord-021894-lq8yr710 293 2 Respiratory respiratory JJ cord-021894-lq8yr710 293 3 syncytial syncytial JJ cord-021894-lq8yr710 293 4 virus virus NN cord-021894-lq8yr710 293 5 , , , cord-021894-lq8yr710 293 6 an an DT cord-021894-lq8yr710 293 7 ongoing ongoing JJ cord-021894-lq8yr710 293 8 medical medical JJ cord-021894-lq8yr710 293 9 dilemma dilemma NN cord-021894-lq8yr710 293 10 : : : cord-021894-lq8yr710 293 11 an an DT cord-021894-lq8yr710 293 12 expert expert JJ cord-021894-lq8yr710 293 13 commentary commentary NN cord-021894-lq8yr710 293 14 on on IN cord-021894-lq8yr710 293 15 respiratory respiratory JJ cord-021894-lq8yr710 293 16 syncytial syncytial JJ cord-021894-lq8yr710 293 17 virus virus NN cord-021894-lq8yr710 293 18 prophylactic prophylactic JJ cord-021894-lq8yr710 293 19 and and CC cord-021894-lq8yr710 293 20 therapeutic therapeutic JJ cord-021894-lq8yr710 293 21 pharmaceuticals pharmaceutical NNS cord-021894-lq8yr710 293 22 currently currently RB cord-021894-lq8yr710 293 23 in in IN cord-021894-lq8yr710 293 24 clinical clinical JJ cord-021894-lq8yr710 293 25 trials trial NNS cord-021894-lq8yr710 293 26 . . . cord-021894-lq8yr710 294 1 Influenza Influenza NNP cord-021894-lq8yr710 294 2 Other other JJ cord-021894-lq8yr710 294 3 Respir Respir NNP cord-021894-lq8yr710 294 4 Viruses virus NNS cord-021894-lq8yr710 294 5 Activity Activity NNP cord-021894-lq8yr710 294 6 of of IN cord-021894-lq8yr710 294 7 oral oral JJ cord-021894-lq8yr710 294 8 ALS-008176 als-008176 NN cord-021894-lq8yr710 294 9 in in IN cord-021894-lq8yr710 294 10 a a DT cord-021894-lq8yr710 294 11 respiratory respiratory JJ cord-021894-lq8yr710 294 12 syncytial syncytial JJ cord-021894-lq8yr710 294 13 virus virus NN cord-021894-lq8yr710 294 14 challenge challenge NN cord-021894-lq8yr710 294 15 study study NN cord-021894-lq8yr710 294 16 Oral oral JJ cord-021894-lq8yr710 294 17 GS-5806 gs-5806 JJ cord-021894-lq8yr710 294 18 activity activity NN cord-021894-lq8yr710 294 19 in in IN cord-021894-lq8yr710 294 20 a a DT cord-021894-lq8yr710 294 21 respiratory respiratory JJ cord-021894-lq8yr710 294 22 syncytial syncytial JJ cord-021894-lq8yr710 294 23 virus virus NN cord-021894-lq8yr710 294 24 challenge challenge NN cord-021894-lq8yr710 294 25 study study NN cord-021894-lq8yr710 295 1 Possible possible JJ cord-021894-lq8yr710 295 2 transmission transmission NN cord-021894-lq8yr710 295 3 by by IN cord-021894-lq8yr710 295 4 fomites fomite NNS cord-021894-lq8yr710 295 5 of of IN cord-021894-lq8yr710 295 6 respiratory respiratory JJ cord-021894-lq8yr710 295 7 syncytial syncytial JJ cord-021894-lq8yr710 295 8 virus virus NN cord-021894-lq8yr710 295 9 Viral viral JJ cord-021894-lq8yr710 295 10 coinfection coinfection NN cord-021894-lq8yr710 295 11 in in IN cord-021894-lq8yr710 295 12 childhood childhood NN cord-021894-lq8yr710 295 13 respiratory respiratory JJ cord-021894-lq8yr710 295 14 tract tract NN cord-021894-lq8yr710 295 15 infections infection NNS cord-021894-lq8yr710 295 16 Respiratory respiratory JJ cord-021894-lq8yr710 295 17 syncytial syncytial JJ cord-021894-lq8yr710 295 18 virus virus NN cord-021894-lq8yr710 295 19 disease disease NN cord-021894-lq8yr710 295 20 in in IN cord-021894-lq8yr710 295 21 infants infant NNS cord-021894-lq8yr710 295 22 despite despite IN cord-021894-lq8yr710 295 23 prior prior JJ cord-021894-lq8yr710 295 24 administration administration NN cord-021894-lq8yr710 295 25 of of IN cord-021894-lq8yr710 295 26 antigenic antigenic JJ cord-021894-lq8yr710 295 27 inactivated inactivate VBN cord-021894-lq8yr710 295 28 vaccine vaccine NN