Treatment of locally advanced non-small cell lung cancer - neoadjuvant or adjuvant chemotherapy: E07-03 Copyright © 2007 by the International Association for the Study of Lung Cancer S237 Journal of Thoracic Oncology • Volume 2, Number 8, Supplement 4, August 2007 12th World Conference on Lung Cancer 4. André F, Grunenwald D, Pignon JP, et al. Survival of patients with resected N2 non- small-cell lung cancer: evidence for a subclassification and implications. J Clin Oncol 2000;18:2981-9 5. Albain KS, Scott CB, Rusch VR, et al.. Phase III comparison of concurrent chemo- therapy plus radiotherapy (CT/RT) and CT/RT followed by surgical resection for stage IIIA(pN2) non-small cell lung cancer (NSCLC): initial results from intergroup trial 0139 (RTOG 93-09). Proc Am Soc Clin Oncol 2003;22:621, (abstr) 6. Albain KS, Rusch VW, Crowley JJ, et al. 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J Thorac Cardiovasc Surg 2001;122:796-802 E07-03 Treatment of Locally Advanced NSCLC, Mon, Sept 3, 16:00 – 17:30 Treatment of locally advanced non-small cell lung cancer - neoadjuvant or adjuvant chemotherapy Vokes, Everett E. The University of Chicago, Chicago, IL, USA Over recent years combined modality therapy has become firmly es- tablished as a standard in the treatment of patients with locoregionally advanced unresectable non-small cell lung cancer (NSCLC). In direct comparison, concomitant chemoradiotherapy was shown repeatedly to be superior to induction chemotherapy. A case can be made that concomitant chemoradiotherapy primarily addresses locoregional dis- ease while induction chemotherapy might be better suited to eradicate distant micrometastatic foci. Therefore, continuing sequential and con- comitant therapy might be beneficial and the addition of induction or adjuvant chemotherapy to the concomitant chemoradiotherapy standard have been investigated. CALGB 39801 compared concomitant chemoradiotherapy using the carboplatin paclitaxel platform versus induction chemotherapy with carboplatin and paclitaxel for two cycles followed by identical chemo- radiotherapy. While a numerical trend favored the induction chemo- therapy arm, there was no significant advantage for overall survival. Similarly, the Hoosier Oncology Group evaluated the administration of concomitant chemoradiotherapy using the cisplatin etoposide platform with or without three additional cycles of consolidation chemotherapy with docetaxel. This study was based on promising pilot data generated by the Southwest Oncology Group. Again, the study showed no signifi- cant survival advantage from the addition of concomitant chemoradio- therapy. Therefore, at the present time, concomitant chemoradiotherapy should be regarded as the standard approach for most patients with unresectable non-small cell lung cancer. Induction chemotherapy may have a role for patients with poor perfor- mance status who may not be candidates to undergo aggressive chemo- radiotherapy. Certain targeted agents might be appropriate to investi- gate in the consolidation setting under carefully defined experimental conditions. This need is highlighted by the recent experience in SWOG 0023 in which the administration of gefitinib as maintenance therapy was found to decrease survival rates. Session E08: New Technology for Diagnosis E08-01 New Technology for Diagnosis, Tue, Sept 4, 16:00 – 17:30 Autofluorescence bronchoscopy and optical coherence tomography Lam, Stephen British Columbia Cancer Agency and The University of British Columbia, Vancouver, BC, Canada The lung is an internal organ consisting of a complex branching system of airways leading to gas exchange units. Lung cancer consists of several cell types instead of a single cell type. Different cell types are preferentially located in different parts of the bronchial tree. There is no single method that can detect pre-invasive cancer in the entire bronchial epithelium and allow simultaneous tissue sampling for pathological diagnosis and molecular profiling. While computerized tomography, magnetic resonance imaging and ultrasound can detect objects in the sub-milliliter scale, photonic imaging can detect structural and func- tional changes in cells and tissues down to the micron and sub-micron