id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_khaed5chrraodf4mvgd35mzafa	Emily Frances Mendez	4141 Molecular Signatures of Cocaine Toxicity in Postmortem Human Brain and Neurons	2020	1	.pdf	application/pdf	966	78	43	RESULTS/ANTICIPATED RESULTS: We determined that normalized MARCKS protein expression is significantly increased in BAL cell the homicide victim population who were institutionalized within 30 potentially prevent these future homicides. Demographics of recently institutionalized homicide victims (RIHV) in the last 30 days were compared to homicide Homicide circumstances for RIHV were more likely to involve on this population to reduce the risk of violent homicides. therapeutic targets and biomarkers to treat or prevent cocaine toxicity by investigating proteomic, transcriptomic and epigenetic signatures of cocaine exposure in human subjects. STUDY POPULATION: Cocaine is a highly addictive neurotoxic cell-derived neuron (hiPSN) model of cocaine exposure from the Pathway analysis of our results revealed alterations in specific pathways involved with neuronal function including voltagegated calcium channels, and GABA receptor signaling. signatures in our sorted neuronal nuclei and our hiPSN model of SIGNIFICANCE OF IMPACT: Neuronal signatures found with this	./cache/work_khaed5chrraodf4mvgd35mzafa.pdf	./txt/work_khaed5chrraodf4mvgd35mzafa.txt