id author title date pages extension mime words sentences flesch summary cache txt work_2xtf2gstifhyza6sahun3emrqi Nadin Neuhauser Expert System for Computer-assisted Annotation of MS/MS Spectra 2012 10 .pdf application/pdf 6114 444 61 An important step in mass spectrometry (MS)-based proteomics is the identification of peptides by their fragment as a large body of high mass accuracy and pure fragmentation spectra. The resulting annotation performance surpasses a human expert, especially on complex spectra spectra— especially of larger peptides— can be quite complex and contain a number of medium or even high abundance peptide fragments that are not annotated by the search spectra from which annotated peaks are drawn to form a large peak collection of possible fragment masses. in the data set, 10 random fragments are inserted and the number of annotations by the Expert System is counted. The FDR for peak annotation rises with peptide length and is strongly dependent on the mass difference. intensities and 24% by peak number are explained, whereas the Expert System almost completely annotates the spectrum (for further ./cache/work_2xtf2gstifhyza6sahun3emrqi.pdf ./txt/work_2xtf2gstifhyza6sahun3emrqi.txt