id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_zbi2knhp65ho5n7vbsuthmd7gi	Shuxi Qiao	The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death	2013	17	.pdf	application/pdf	12825	1552	42	Pharmacological inhibition of autophagic-lysosomal function has recently emerged as a promising strategy for chemotherapeutic intervention targeting cancer cells. the first time that amodiaquine (aQ), a clinical 4-aminoquinoline antimalarial with unexplored cancer-directed chemotherapeutic potential, causes autophagic-lysosomal and proliferative blockade in melanoma cells that surpasses that of aQ displayed potent antiproliferative effects, and gene expression array analysis revealed changes at the mRNa (CDKN1A, E2F1) and protein level efforts that aim at targeting autophagic-lysosomal function and proliferative control in malignant melanoma cells. Here we report for the first time that AQ targets malignant melanoma cells with pronounced induction of autophagic-lysosomal amodiaquine-induced autophagic-lysosomal alterations in human malignant melanoma cells. amodiaquine-induced loss of cathepsin enzymatic activity in human malignant melanoma cells. Gene expression array analysis reveals an AQ-induced proliferative blockade in A375 melanoma cells cell stress and autophagy-related genes contained on the combined array, 25 genes displayed AQ-induced expression changes 	./cache/work_zbi2knhp65ho5n7vbsuthmd7gi.pdf	./txt/work_zbi2knhp65ho5n7vbsuthmd7gi.txt