id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_vhxav5ieybduninmn3cmjlaxcm	Mingtong Ye	Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis	2019	8	.pdf	application/pdf	5360	436	59	 Corresponding authors: Zhenfeng Zhang, 250 Changgang Rd East, Guangzhou, 510260, China; E-mail: zhangzhf@gzhmu.edu.cn; and Lili Yang, 74 Since vitamin C enabled the inhibition of glycolysis of cancer cells, and erlotinib-resistant sub-line of HCC827 (ER6 cells) switched its metabolic features to higher glycolysis for reduced vitamin C and oxidized vitamin C (DHA) could selectively suppress the viability of ER6 cells. Key words: Drug resistance; oxidized vitamin C (DHA); energy homeostasis; glycolysis. Reduced vitamin C decreases viability of ER6 cells in both normal and glucose free condition. Viability analysis of ER6 and HCC827 cells with supplement of reduced vitamin C for 24 hrs (B) and 48 hrs (C) in normal glucose Viability analysis of ER6 and HCC827 cells with reduced vitamin C and glucose starvation for 24 hrs (D) Viability analysis of ER6 and HCC827 cells with DHA and glucose starvation for 24 hrs.	./cache/work_vhxav5ieybduninmn3cmjlaxcm.pdf	./txt/work_vhxav5ieybduninmn3cmjlaxcm.txt