id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_s2u4axhwrvd53fwavnu5cc6kli	Shilpy Joshi	The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis	2015	15	.pdf	application/pdf	9418	941	41	that arise early in renal tumorigenesis trigger a metabolic checkpoint, trafficking and lysosome defects, and failure of mitochondrial quality control, activating p53 and AMPK as a barrier to Oncocytomas have mitochondrial genome mutations responsible for respiration defects (Gasparre et al., 2007; Mayr et al., Thus, the distinguishing feature of both subtypes of renal oncocytoma is recurrent inactivating mutations in mitochondrial genes encoded by (D) Karyotype of renal oncocytomas shows chromosomal rearrangement including translocations, inversions, and deletions near CCND1 in type 1 and loss of burden of the mitochondrial genome in ChRCC compared to oncocytoma (p < 0.0001) (Figure 1B) (Davis et al., 2014). Oncocytomas Show a Gene Expression Signature of Oxidative Metabolism and Mitochondrial and Energetic Defects The mitochondrial accumulation and genome mutations, oxidative metabolism gene expression signature, and patterns of chromosome (B) Western blots of indicated mitochondrial and autophagy proteins in normal tissues and oncocytomas.	./cache/work_s2u4axhwrvd53fwavnu5cc6kli.pdf	./txt/work_s2u4axhwrvd53fwavnu5cc6kli.txt