id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_qyh7sb3pqbflpgnl4iihwhnnsq	Jiska van der Reest	Anti-cancer effects of vitamin C revisited	2016	2	.pdf	application/pdf	1586	118	59	toxicity induced by high-dose vitamin cancer cells and converted to vitamin C, reduction of DHA back to vitamin C reduction of DHA back to vitamin C to DHA, GAPDH itself was oxidized with high doses of vitamin C reduced Thus, ROS cause the inhibition of GAPDH activity in cells on [1] to therapeutic application raises concerns regarding toxicities of high-dose vitamin C treatment. driven cancer cells, high-dose vitamin C treatment induces cell death via the uptake and reduction of its oxidized form DHA back to vitamin C. 9 Agus DB, Vera JC, Golde DW. KRAS and BRAF mutations induce metabolic reprogramming by upregulating GLUT1, glucose uptake, and glycolytic flux. taken up through GLUT1 and is reduced back to vitamin C in the cells, depleting damage induces PARP activation and subsequently, NAD+ levels fall and cause additional inhibition of GAPDH and glycolysis, resulting in energy crisis and cell death.	./cache/work_qyh7sb3pqbflpgnl4iihwhnnsq.pdf	./txt/work_qyh7sb3pqbflpgnl4iihwhnnsq.txt