id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_oju7vq6z4rfrhczefxym6xmamm	Alexander M. Wolf	S10.4 Mild uncoupling reduces oxidative stress in intact cells	2008	1	.pdf	application/pdf	1025	84	43	shown to interact with lower affinity with mitochondrial cytochrome c Apoptosis has been considered as a form of cell death, to which a Similarly caspase activation does not inevitably commit a cell to death, circumstances) be reversible and is not always a form of cell death. nitric oxide and reactive oxygen signaling at the mitochondrial E-mail: paul_brookes@urmc.rochester.edu S10.4 Mild uncoupling reduces oxidative stress in intact cells "Mild uncoupling", the introduction of a limited proton conductance into the mitochondrial inner membrane, has been demonstrated to greatly reduce reactive oxygen species (ROS) production in isolated to reduce oxidative stress in intact cells and ultimately in vivo, or targeted to mitochondria of PC12 cells, we found that mild uncoupling limited to a certain range of membrane potential, and that uncoupling beyond this range will increase oxidative stress probably due to the levels of urea, creatinine and cell death markers increase. mailto:paul_brookes@urmc.rochester.edu	./cache/work_oju7vq6z4rfrhczefxym6xmamm.pdf	./txt/work_oju7vq6z4rfrhczefxym6xmamm.txt