id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_mypiltbhjncilcgoht35m74fvu	H. Kioka	Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation	2013	6	.pdf	application/pdf	5962	802	55	In this study, selective measurement of intramitochondrial ATP levels identified the hypoxia-inducible protein G0/G1 show that G0s2 positively regulates OXPHOS activity by interacting with FoF1-ATP synthase, which causes an increase in ATP production in response to hypoxic stress and protects cells from a ATP levels to evaluate OXPHOS activity in living cells. in living cells revealed that [ATP]mito reflected OXPHOS activity We developed a sensitive method to assess the activity of oxidative phosphorylation in living cells using a FRET-based ATP We then revealed that G0/G1 switch gene 2, a protein rapidly induced by hypoxia, increases mitochondrial ATP Our results suggest that hypoxia-induced protein G0s2 is a positive regulator of OXPHOS and protects cells We compared the gene expression profiles of cultured rat cardiomyocytes at three different time points during hypoxic conditions (0, 2, and 12 h) (Fig. S2A). G0s2-Flag was also found to be associated with the FoF1-ATP synthase in 293T and HeLa cells (Fig. S4C).	./cache/work_mypiltbhjncilcgoht35m74fvu.pdf	./txt/work_mypiltbhjncilcgoht35m74fvu.txt