id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_muqnvxxc3fda7ofhmw6r6yscsm	Sai Ma	The role of the autophagy in myocardial ischemia/reperfusion injury	2015	6	.pdf	application/pdf	5645	663	38	This paper is to review the functional significance of autophagy in cardiac ischemia reperfusion injury and discuss underlying signaling pathways. Autophagy is a cellular process associated with damaged or unnecessary protein and organelle degradation [1]. Under the condition of cardiac ischemia reperfusion injury (I/R injury), the process of autophagy is activated in response further verified by the finding that autophagy in the initial phase of ischemia was accompanied by AMPK activation and was diminished by AMPK is an essential molecule for autophagy initiation in cardiac ischemia. It was confirmed that inhibition of autophagy with 3-MA decreased ATP generation and aggravated cardiac cell death in response to glucose during the initial phase of cardiac ischemia contributes to protective autophagy, pharmacologic drugs for AMPK activation are increasingly attractive as therapeutic targets. Beclin-1 mediated autophagy during cardiac reperfusion phase Beclin-1 mediated autophagy during cardiac reperfusion phase	./cache/work_muqnvxxc3fda7ofhmw6r6yscsm.pdf	./txt/work_muqnvxxc3fda7ofhmw6r6yscsm.txt