id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_mp337sycercnzm7ymaunarhohe	Marta M. Lipinski	A Cellular Response to an Internal Energy Crisis	2005	3	.pdf	application/pdf	2277	230	62	(2005) describe a new mechanism that directly links nutrient availability to apoptosis in Xenopus oocytes and show that age-dependent changes that take place when oocytes exhaust their internal energy stores and define a new pathway regulating cell If oocytes undergo apoptosis in response to insufficient nutrients, then the loss of caspase-2, a proposed mediator of cell death induced by nutrient depletion, would oocyte apoptosis, caspase-2 operates upstream of mitochondrial events and may exert its effects through regulation of the Bcl-2 family, it is not clear which members might serve as the upstream molecular sensor of glucose levels signaling to caspase-2. Given that NGF also regulates glucose uptake in neurons, it is conceivable that caspase-2 could be activated in sympathetic neurons deprived of NGF due to Other caspases may also be involved in mediating apoptosis induced by energy crisis. hat, perhaps in caspase-2-deficient cells, Akt activity o cell death through either activation of caspase-2 or an	./cache/work_mp337sycercnzm7ymaunarhohe.pdf	./txt/work_mp337sycercnzm7ymaunarhohe.txt