id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_m63nygzx2zh7laddmxivny2n4q	Danielle L Ippolito	Alteration in circulating metabolites during and after heat stress in the conscious rat: potential biomarkers of exposure and organ-specific injury	2014	17	.pdf	application/pdf	10464	826	47	and proteomic responses to heat injury and recovery in multiple organs in an in vivo model of conscious rats identified 15 biochemicals that differentiated animals with histopathological evidence of cardiac injury at 48 hours approach to assessing individual susceptibility to organ injury and predicting recovery after heat stress. heat stress from control during recovery: 5,6-dihydrouracil, 3-ureidopropionate, GSSG, ornithine, creatinine, corticosterone and pyridoxal (Table 1). The glutathione (GSH) metabolic network exhibited profound perturbation in response to heat stress (Figure 2). Table 1 List of seven key biochemical differentially expressed in heat-stressed and control animals* Fourteen out of 18 identified biochemicals in the pyrimidine and purine metabolic pathways were significantly different at Tc,Max relative to control (Figure 1 and Additional biomarkers within five metabolic networks which discriminated heat stressed individuals from controls at any time Figure 6 Random forest analysis accurately discriminates heat exposure from unheated controls at Tc,Max. The top 30 metabolites were	./cache/work_m63nygzx2zh7laddmxivny2n4q.pdf	./txt/work_m63nygzx2zh7laddmxivny2n4q.txt