id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_lyvuvbro7jginjx7i3najsntvq	Jessie Yanxiang Guo	Autophagy, Metabolism, and Cancer	2016	12	.pdf	application/pdf	5045	800	64	During fasting, normal adult mice activate autophagy at the cellular level to sustain cell autophagy gene Atg7 have a systemic metabolic defect that is fatal during fasting (KarsliUzunbas et al. As autophagy is essential for glucose homeostasis in fasted adult mice, is there a role also in cancer where essential autophagy genes are deleted in tumor cells arising spontaneously in ras-driven lung and pancreatic cancer, loss of autophagy limits tumor progression to benign How does autophagy promote survival of cells in starvation? autophagy dependent as isogenic Atg7-deficient tumor cells are more sensitive to starvation starvation conditions is most effective at rescuing the survival of autophagy-deficient tumor metabolism was also apparent in the Atg7-deficient tumor cells, although it was significantly Starving Atg7-deficient tumor cells severely depletes nucleotide pools, particularly The depletion of nucleotide pools and energy crisis in starved autophagy-deficient tumor Defective autophagy in tumor cells alters metabolic flux from glutamine to aspartate and to 	./cache/work_lyvuvbro7jginjx7i3najsntvq.pdf	./txt/work_lyvuvbro7jginjx7i3najsntvq.txt