id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_je3tkn6zcnaytoe2qbd7wjnvfi	Kai Kaila	GABA actions and ionic plasticity in epilepsy	2014	8	.pdf	application/pdf	6947	737	53	The driving force of GABAergic currents is controlled by ionregulatory molecules such as the neuronal K-Cl cotransporter and robust changes in neuronal plasticity and a fast development of pharmacoresistance to conventional antiepileptic drugs which enhance GABAergic transmission. Work on brain slices has shown that the efficacy of feedforward inhibition declines rapidly after recurrent seizure-like domains of neuronal Cl--loading mechanisms following seizure Neuronal ion regulation sets the driving force for GABAA receptor-mediated currents. In mature neurons the K-Cl cotransporter isoform 2, KCC2, mediates Cl� extrusion driven by the K+ gradient while the Na-K-2Cl hyperpolarizing IPSPs seen in mature neurons depend on the functional expression of KCC2 (left) that maintains a low intracellular Cl� level that favors Tonic GABAAR-mediated signaling is based on the activation of Fast, seizure-induced downregulation of KCC2 activity The molecular mechanisms underlying seizure-induced erosion of inhibition at the level of neuronal Cl� regulation are largely unknown.	./cache/work_je3tkn6zcnaytoe2qbd7wjnvfi.pdf	./txt/work_je3tkn6zcnaytoe2qbd7wjnvfi.txt