id author title date pages extension mime words sentences flesch summary cache txt work_fq6ralclurfmlins2azgofbfti Nektarios Tavernarakis Cardiomyocyte necrosis: Alternative mechanisms, effective interventions 2007 3 .pdf application/pdf 1782 185 46 Necrotic death of cardiac myocytes is a major contributor to heart failure associated with several cardiac pathologies such as ischemia and While, necrotic cell death was traditionally considered a passive and chaotic process, emerging evidence indicates that Keywords: Ischemia; Lipid; Mitochondria; Necrotic cell death; Oxidative stress; Peroxidation; Reperfusion neurodegenerative conditions, the biochemical pathways mediating the necrotic destruction of cells have long remained notion that necrosis is a catastrophic type of cell death that is necrotic cell death can also be inflicted by genetic abnormalities once induced, necrotic cell death was considered inevitable, the pathologies, ensuing cardiomyocyte cell death is a major necrotic cell death in C. Membrane lipid peroxidation contributes to oxidative stress-induced cell dea formulating effective interventions against necrotic cell death Kroemer, Cell death by necrosis: towards a molecular Tavernarakis, Death by necrosis. permeability transition in cell death, Apoptosis (2006). mitochondrial permeability transition in cell death, Nature 434 (2005) ./cache/work_fq6ralclurfmlins2azgofbfti.pdf ./txt/work_fq6ralclurfmlins2azgofbfti.txt