id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ficzxzd4gfgvjjz735gz73cq44	Laura Schöckel	Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth	2015	16	.pdf	application/pdf	11893	2016	69	Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth small molecule inhibitor vemurafenib increased the OXPHOS dependency of BRAF mutant melanoma cells. system, we here report that BAY 87-2243-mediated complex I inhibition induced melanoma cell death in vitro and Our results suggest that this effect is mediated through BAY 87-2243-induced stimulation of mitochondrial ROS production, leading to oxidative damage Fig. 1 Inhibition of mitochondrial complex I with BAY 87-2243 in melanoma cells induces cell death in vitro and reduces tumor growth in vivo. a BRAF wild type and mutant melanoma cells were treated with various concentrations of BAY 87-2243. Fig. 2 Inhibition of mitochondrial complex I with BAY 87-2243 blocks OXPHOS and triggers glycolysis in melanoma cells. Fig. 3 Complex I inhibition using BAY 87-2243 reduces ATP levels and induces an energy crisis in melanoma cells. Fig. 4 BAY 87-2243-mediated complex I inhibition increases mitochondrial and cytosolic ROS levels resulting in ROS-mediated cell death.	./cache/work_ficzxzd4gfgvjjz735gz73cq44.pdf	./txt/work_ficzxzd4gfgvjjz735gz73cq44.txt