id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_web4pprjrfcvplxngghqmdafuu	H U Barthelmes	Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells	2001.0	7	.pdf	application/pdf	5650	570	67	Lycobetaine acts as a selective topoisomerase II • poison and inhibits the growth of human tumour cells Athymic nude mice, carrying s.c. implanted human gastric tumour xenograft GXF251, were treated i.p. with lycobetaine of calf thymus DNA, pure recombinant human topoisomerase IIβ protein was selectively depleted from SDS-gels, whereas no depletion of Keywords: lycobetaine; ungeremine; topoisomerase IIβ; cleavable complex; clonogenic assay; gastric carcinoma Table 1 Effect of lycobetaine on the growth of human tumour cell lines of topoisomerase-directed drug effects in cells, we used human xenograft cells shows that lycobetaine inhibits the growth of the 21 Figure 2 Activity profile of lycobetaine on the growth of human tumour xenografts in the clonogenic assay. Again, the lycobetaine effect on the DNA linkage of topoisomerase IIβ had a maximum between 10–30 µM and decreased at Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells	./cache/work_web4pprjrfcvplxngghqmdafuu.pdf	./txt/work_web4pprjrfcvplxngghqmdafuu.txt