id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_bl6eatcw4nhwlkfii5kp7vs5mi	Aimee M. Two	Reduction in Serine Protease Activity Correlates with Improved Rosacea Severity in a Small, Randomized Pilot Study of a Topical Serine Protease Inhibitor	2014.0	3	.pdf	application/pdf	2910	813	81	Reduction in Serine Protease Activity Correlates with Improved Rosacea Severity in a Small, Randomized Pilot Study of a Topical Serine Protease Inhibitor baseline levels of cathelicidin and kallikrein 5 (KLK5; Yamasaki et al., 2007). formulation, called SEI003, would permit us to test the hypothesis that inhibition of SPA improves rosacea. In vitro effects of SEI003 and aprotinin on KLK and human total stratum corneum protease (a) Both SEI003 and aprotinin inhibit KLK activity compared to vehicle alone. Global Assessment; KLK, kallikrein; SPA, serine protease activity; UCSD, University of California, individual subjects in the treatment group tended to decrease over time. (d) SPA levels of individual subjects in the placebo group remained relatively unchanged (e) IGA scores decreased throughout the study for participants in both groups, however scores were only significant for time and the interaction between (g) Decreased erythema is seen in patients in the treatment group at week 12.	./cache/work_bl6eatcw4nhwlkfii5kp7vs5mi.pdf	./txt/work_bl6eatcw4nhwlkfii5kp7vs5mi.txt