id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_abtdn2u6vra35kojlcd2m3cpxm	Tarek El-Hamoly	Activation of Poly(ADP-Ribose) Polymerase-1 Delays Wound Healing by Regulating Keratinocyte Migration and Production of Inflammatory Mediators	2014.0	9	.pdf	application/pdf	6900	912	62	necrosis factor (TNF)-α, inducible nitric oxide synthase and matrix metalloproteinase-9 was lower in the wounds of PARP-1 knockout mice as compared with control, and expression of IL-1β, cyclooxygenase-2, TIMP-1 and -2 also were affected. The level of nitrotyrosine (a marker of nitrating stress) was lower in the wounds of PARP-1 knockout animals as compared with controls. These data suggest that PARylation by PARP-1 slows down the wound healing process by increasing the production chemokines, cell proliferation and migration) in the wound healing process, situations such as wound healing, we hypothesized that the effects of PARP inhibitors is mainly due to inhibition of wounds on wild-type mice (Figure 3), confirming that activation of PARP-1 leads to PARP-1 knockout animals or in PARP inhibitor-treated mice may result in accelerated wound healing. likely to explain accelerated wound healing in PARP-1-deficient mice. wound healing in PARP-1 deficient mice.	./cache/work_abtdn2u6vra35kojlcd2m3cpxm.pdf	./txt/work_abtdn2u6vra35kojlcd2m3cpxm.txt