id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_4nip6utqujcrziqlf7v5pwo26u	J. C. Isenburg	Elastin Stabilization for Treatment of Abdominal Aortic Aneurysms	2007.0	9	.pdf	application/pdf	6668	555	49	Background—Maintaining the integrity of arterial elastin is vital for the prevention of abdominal aortic aneurysm (AAA) PGG inhibits elastin degeneration, attenuates aneurysmal expansion, and hinders AAA development in rats without Abdominal aortic aneurysms (AAAs) are associatedwith impaired arterial wall integrity, leading to abnormal ballooning and eventual fatal rupture. fiber integrity and hinders aneurysmal dilatation of the abdominal aorta in a clinically relevant animal model of AAA. In experiment 1, PGG was applied to healthy abdominal aorta immediately before CaCl2-mediated injury, and AAA development was In experiment 2, PGG was applied to aneurysmal aorta, and development of advanced AAA was monitored for another 28 days. stabilizes aortic tissue by binding to elastic fibers, we designed 2 experiments to test the in vivo efficacy of PGG in Adult rat abdominal aortas were treated periadventitially with PGG for 15 minutes, rinsed, and then exposed to CaCl2-mediated chemical injury to induce aneurysm formation. Delivery of PGG to aneurysmal aorta prevents AAA progression.	./cache/work_4nip6utqujcrziqlf7v5pwo26u.pdf	./txt/work_4nip6utqujcrziqlf7v5pwo26u.txt