id sid tid token lemma pos www-nature-com-2208 1 1 The the DT www-nature-com-2208 1 2 FAIR FAIR NNP www-nature-com-2208 1 3 Guiding Guiding NNP www-nature-com-2208 1 4 Principles Principles NNPS www-nature-com-2208 1 5 for for IN www-nature-com-2208 1 6 scientific scientific JJ www-nature-com-2208 1 7 data data NN www-nature-com-2208 1 8 management management NN www-nature-com-2208 1 9 and and CC www-nature-com-2208 1 10 stewardship stewardship NN www-nature-com-2208 1 11 | | NNP www-nature-com-2208 1 12 Scientific Scientific NNP www-nature-com-2208 1 13 Data Data NNP www-nature-com-2208 1 14 Skip Skip NNP www-nature-com-2208 1 15 to to IN www-nature-com-2208 1 16 main main JJ www-nature-com-2208 1 17 content content NN www-nature-com-2208 1 18 Thank thank VBP www-nature-com-2208 1 19 you -PRON- PRP www-nature-com-2208 1 20 for for IN www-nature-com-2208 1 21 visiting visit VBG www-nature-com-2208 1 22 nature.com nature.com ADD www-nature-com-2208 1 23 . . . www-nature-com-2208 2 1 You 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NNP www-nature-com-2208 5 58 Wilkinson Wilkinson NNP www-nature-com-2208 5 59     _SP www-nature-com-2208 5 60 ORCID ORCID NNP www-nature-com-2208 5 61 : : : www-nature-com-2208 5 62 orcid.org/0000-0001-6960-357X1 orcid.org/0000-0001-6960-357X1 NNP www-nature-com-2208 5 63 , , , www-nature-com-2208 5 64 Michel Michel NNP www-nature-com-2208 5 65 Dumontier Dumontier NNP www-nature-com-2208 5 66     _SP www-nature-com-2208 5 67 ORCID ORCID NNP www-nature-com-2208 5 68 : : : www-nature-com-2208 5 69 orcid.org/0000-0003-4727-94352 orcid.org/0000-0003-4727-94352 CD www-nature-com-2208 5 70 , , , www-nature-com-2208 5 71 IJsbrand IJsbrand NNP www-nature-com-2208 5 72 Jan Jan NNP www-nature-com-2208 5 73 Aalbersberg Aalbersberg NNP www-nature-com-2208 5 74     _SP www-nature-com-2208 5 75 ORCID ORCID NNP www-nature-com-2208 5 76 : : : www-nature-com-2208 5 77 orcid.org/0000-0002-0209-44803 orcid.org/0000-0002-0209-44803 CD www-nature-com-2208 5 78 , , , www-nature-com-2208 5 79 Gabrielle Gabrielle NNP www-nature-com-2208 5 80 Appleton Appleton NNP www-nature-com-2208 5 81     _SP www-nature-com-2208 5 82 ORCID ORCID NNP www-nature-com-2208 5 83 : : : www-nature-com-2208 5 84 orcid.org/0000-0003-0179-73843 orcid.org/0000-0003-0179-73843 LS www-nature-com-2208 5 85 , , , www-nature-com-2208 5 86 Myles Myles NNP www-nature-com-2208 5 87 Axton Axton NNP www-nature-com-2208 5 88     _SP www-nature-com-2208 5 89 ORCID ORCID NNP www-nature-com-2208 5 90 : : : www-nature-com-2208 5 91 orcid.org/0000-0002-8042-41314 orcid.org/0000-0002-8042-41314 CD www-nature-com-2208 5 92 , , , www-nature-com-2208 5 93 Arie Arie NNP www-nature-com-2208 5 94 Baak Baak NNP www-nature-com-2208 5 95     _SP www-nature-com-2208 5 96 ORCID ORCID NNP www-nature-com-2208 5 97 : : : www-nature-com-2208 5 98 orcid.org/0000-0003-2829-67155 orcid.org/0000-0003-2829-67155 LS www-nature-com-2208 5 99 , , , www-nature-com-2208 5 100 Niklas Niklas NNP www-nature-com-2208 5 101 Blomberg Blomberg NNP www-nature-com-2208 5 102     _SP www-nature-com-2208 5 103 ORCID ORCID NNP www-nature-com-2208 5 104 : : : www-nature-com-2208 5 105 orcid.org/0000-0003-4155-59106 orcid.org/0000-0003-4155-59106 CD www-nature-com-2208 5 106 , , , www-nature-com-2208 5 107 Jan Jan NNP www-nature-com-2208 5 108 - - HYPH www-nature-com-2208 5 109 Willem Willem NNP www-nature-com-2208 5 110 Boiten Boiten NNP www-nature-com-2208 5 111     _SP www-nature-com-2208 5 112 ORCID ORCID NNP www-nature-com-2208 5 113 : : : www-nature-com-2208 5 114 orcid.org/0000-0003-0327-638X7 orcid.org/0000-0003-0327-638X7 NNP www-nature-com-2208 5 115 , , , www-nature-com-2208 5 116 Luiz Luiz NNP www-nature-com-2208 5 117 Bonino Bonino NNP www-nature-com-2208 5 118 da da NNP www-nature-com-2208 5 119 Silva Silva NNP www-nature-com-2208 5 120 Santos Santos NNP www-nature-com-2208 5 121     _SP www-nature-com-2208 5 122 ORCID ORCID NNP www-nature-com-2208 5 123 : : : www-nature-com-2208 5 124 orcid.org/0000-0002-1164-13518 orcid.org/0000-0002-1164-13518 LS www-nature-com-2208 5 125 , , , www-nature-com-2208 5 126 Philip Philip NNP www-nature-com-2208 5 127 E. 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find VB www-nature-com-2208 9 27 and and CC www-nature-com-2208 9 28 use use VB www-nature-com-2208 9 29 the the DT www-nature-com-2208 9 30 data datum NNS www-nature-com-2208 9 31 , , , www-nature-com-2208 9 32 in in IN www-nature-com-2208 9 33 addition addition NN www-nature-com-2208 9 34 to to IN www-nature-com-2208 9 35 supporting support VBG www-nature-com-2208 9 36 its -PRON- PRP$ www-nature-com-2208 9 37 reuse reuse NN www-nature-com-2208 9 38 by by IN www-nature-com-2208 9 39 individuals individual NNS www-nature-com-2208 9 40 . . . www-nature-com-2208 10 1 This this DT www-nature-com-2208 10 2 Comment comment NN www-nature-com-2208 10 3 is be VBZ www-nature-com-2208 10 4 the the DT www-nature-com-2208 10 5 first first JJ www-nature-com-2208 10 6 formal formal JJ www-nature-com-2208 10 7 publication publication NN www-nature-com-2208 10 8 of of IN www-nature-com-2208 10 9 the the DT www-nature-com-2208 10 10 FAIR FAIR NNP www-nature-com-2208 10 11 Principles Principles NNPS 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www-nature-com-2208 16 18 facilitate facilitate VBP www-nature-com-2208 16 19 and and CC www-nature-com-2208 16 20 simplify simplify VB www-nature-com-2208 16 21 this this DT www-nature-com-2208 16 22 ongoing ongoing JJ www-nature-com-2208 16 23 process process NN www-nature-com-2208 16 24 of of IN www-nature-com-2208 16 25 discovery discovery NN www-nature-com-2208 16 26 , , , www-nature-com-2208 16 27 evaluation evaluation NN www-nature-com-2208 16 28 , , , www-nature-com-2208 16 29 and and CC www-nature-com-2208 16 30 reuse reuse VB www-nature-com-2208 16 31 in in IN www-nature-com-2208 16 32 downstream downstream JJ www-nature-com-2208 16 33 studies study NNS www-nature-com-2208 16 34 . . . www-nature-com-2208 17 1 What what WP www-nature-com-2208 17 2 constitutes constitute VBZ www-nature-com-2208 17 3 ‘ ' `` www-nature-com-2208 17 4 good good JJ www-nature-com-2208 17 5 data data NN www-nature-com-2208 17 6 management management NN www-nature-com-2208 17 7 ’ ' '' www-nature-com-2208 17 8 is be VBZ www-nature-com-2208 17 9 , , , www-nature-com-2208 17 10 however however RB www-nature-com-2208 17 11 , , , www-nature-com-2208 17 12 largely largely RB www-nature-com-2208 17 13 undefined undefined JJ www-nature-com-2208 17 14 , , , www-nature-com-2208 17 15 and and CC www-nature-com-2208 17 16 is be VBZ www-nature-com-2208 17 17 generally generally RB www-nature-com-2208 17 18 left leave VBN www-nature-com-2208 17 19 as as IN www-nature-com-2208 17 20 a a DT www-nature-com-2208 17 21 decision decision NN www-nature-com-2208 17 22 for for IN www-nature-com-2208 17 23 the the DT www-nature-com-2208 17 24 data datum NNS www-nature-com-2208 17 25 or or CC www-nature-com-2208 17 26 repository repository NN www-nature-com-2208 17 27 owner owner NN www-nature-com-2208 17 28 . . . www-nature-com-2208 18 1 Therefore therefore RB www-nature-com-2208 18 2 , , , www-nature-com-2208 18 3 bringing bring VBG www-nature-com-2208 18 4 some some DT www-nature-com-2208 18 5 clarity clarity NN www-nature-com-2208 18 6 around around IN www-nature-com-2208 18 7 the the DT www-nature-com-2208 18 8 goals goal NNS www-nature-com-2208 18 9 and and CC www-nature-com-2208 18 10 desiderata desiderata NN www-nature-com-2208 18 11 of of IN www-nature-com-2208 18 12 good good JJ www-nature-com-2208 18 13 data data NN www-nature-com-2208 18 14 management management NN www-nature-com-2208 18 15 and and CC www-nature-com-2208 18 16 stewardship stewardship NN www-nature-com-2208 18 17 , , , www-nature-com-2208 18 18 and and CC www-nature-com-2208 18 19 defining define VBG www-nature-com-2208 18 20 simple simple JJ www-nature-com-2208 18 21 guideposts guidepost NNS www-nature-com-2208 18 22 to to TO www-nature-com-2208 18 23 inform inform VB www-nature-com-2208 18 24 those those DT www-nature-com-2208 18 25 who who WP www-nature-com-2208 18 26 publish publish VBP www-nature-com-2208 18 27 and/or and/or CC www-nature-com-2208 18 28 preserve preserve VBP www-nature-com-2208 18 29 scholarly scholarly JJ www-nature-com-2208 18 30 data datum NNS www-nature-com-2208 18 31 , , , www-nature-com-2208 18 32 would would MD www-nature-com-2208 18 33 be be VB www-nature-com-2208 18 34 of of IN www-nature-com-2208 18 35 great great JJ www-nature-com-2208 18 36 utility utility NN www-nature-com-2208 18 37 . . . www-nature-com-2208 19 1 This this DT www-nature-com-2208 19 2 article article NN www-nature-com-2208 19 3 describes describe VBZ www-nature-com-2208 19 4 four four CD www-nature-com-2208 19 5 foundational foundational JJ www-nature-com-2208 19 6 principles principle NNS www-nature-com-2208 19 7 — — : www-nature-com-2208 19 8 Findability findability NN www-nature-com-2208 19 9 , , , www-nature-com-2208 19 10 Accessibility Accessibility NNP www-nature-com-2208 19 11 , , , www-nature-com-2208 19 12 Interoperability Interoperability NNP www-nature-com-2208 19 13 , , , www-nature-com-2208 19 14 and and CC www-nature-com-2208 19 15 Reusability Reusability NNP www-nature-com-2208 19 16 — — : www-nature-com-2208 19 17 that that WDT www-nature-com-2208 19 18 serve serve VBP www-nature-com-2208 19 19 to to TO www-nature-com-2208 19 20 guide guide VB www-nature-com-2208 19 21 data data NN www-nature-com-2208 19 22 producers producer NNS www-nature-com-2208 19 23 and and CC www-nature-com-2208 19 24 publishers publisher NNS www-nature-com-2208 19 25 as as IN www-nature-com-2208 19 26 they -PRON- PRP www-nature-com-2208 19 27 navigate navigate VBP www-nature-com-2208 19 28 around around IN www-nature-com-2208 19 29 these these DT www-nature-com-2208 19 30 obstacles obstacle NNS www-nature-com-2208 19 31 , , , www-nature-com-2208 19 32 thereby thereby RB www-nature-com-2208 19 33 helping help VBG www-nature-com-2208 19 34 to to TO www-nature-com-2208 19 35 maximize maximize VB www-nature-com-2208 19 36 the the DT www-nature-com-2208 19 37 added add VBN www-nature-com-2208 19 38 - - HYPH www-nature-com-2208 19 39 value value NN www-nature-com-2208 19 40 gained gain VBN www-nature-com-2208 19 41 by by IN www-nature-com-2208 19 42 contemporary contemporary JJ www-nature-com-2208 19 43 , , , www-nature-com-2208 19 44 formal formal JJ www-nature-com-2208 19 45 scholarly scholarly RB www-nature-com-2208 19 46 digital digital JJ www-nature-com-2208 19 47 publishing publishing NN www-nature-com-2208 19 48 . . . www-nature-com-2208 20 1 Importantly importantly RB www-nature-com-2208 20 2 , , , www-nature-com-2208 20 3 it -PRON- PRP www-nature-com-2208 20 4 is be VBZ www-nature-com-2208 20 5 our -PRON- PRP$ www-nature-com-2208 20 6 intent intent NN www-nature-com-2208 20 7 that that WDT www-nature-com-2208 20 8 the the DT www-nature-com-2208 20 9 principles principle NNS www-nature-com-2208 20 10 apply apply VBP www-nature-com-2208 20 11 not not RB www-nature-com-2208 20 12 only only RB www-nature-com-2208 20 13 to to IN www-nature-com-2208 20 14 ‘ ' `` www-nature-com-2208 20 15 data datum NNS www-nature-com-2208 20 16 ’ ' '' www-nature-com-2208 20 17 in in IN www-nature-com-2208 20 18 the the DT www-nature-com-2208 20 19 conventional conventional JJ www-nature-com-2208 20 20 sense sense NN www-nature-com-2208 20 21 , , , www-nature-com-2208 20 22 but but CC www-nature-com-2208 20 23 also also RB www-nature-com-2208 20 24 to to IN www-nature-com-2208 20 25 the the DT www-nature-com-2208 20 26 algorithms algorithm NNS www-nature-com-2208 20 27 , , , www-nature-com-2208 20 28 tools tool NNS www-nature-com-2208 20 29 , , , www-nature-com-2208 20 30 and and CC www-nature-com-2208 20 31 workflows workflow NNS www-nature-com-2208 20 32 that that WDT www-nature-com-2208 20 33 led lead VBD www-nature-com-2208 20 34 to to IN www-nature-com-2208 20 35 that that DT www-nature-com-2208 20 36 data datum NNS www-nature-com-2208 20 37 . . . www-nature-com-2208 21 1 All all DT www-nature-com-2208 21 2 scholarly scholarly JJ www-nature-com-2208 21 3 digital digital JJ www-nature-com-2208 21 4 research research NN www-nature-com-2208 21 5 objects2—from objects2—from : www-nature-com-2208 21 6 data datum NNS www-nature-com-2208 21 7 to to IN www-nature-com-2208 21 8 analytical analytical JJ www-nature-com-2208 21 9 pipelines pipeline NNS www-nature-com-2208 21 10 — — : www-nature-com-2208 21 11 benefit benefit NN www-nature-com-2208 21 12 from from IN www-nature-com-2208 21 13 application application NN www-nature-com-2208 21 14 of of IN www-nature-com-2208 21 15 these these DT www-nature-com-2208 21 16 principles principle NNS www-nature-com-2208 21 17 , , , www-nature-com-2208 21 18 since since IN www-nature-com-2208 21 19 all all DT www-nature-com-2208 21 20 components component NNS www-nature-com-2208 21 21 of of IN www-nature-com-2208 21 22 the the DT www-nature-com-2208 21 23 research research NN www-nature-com-2208 21 24 process process NN www-nature-com-2208 21 25 must must MD www-nature-com-2208 21 26 be be VB www-nature-com-2208 21 27 available available JJ www-nature-com-2208 21 28 to to TO www-nature-com-2208 21 29 ensure ensure VB www-nature-com-2208 21 30 transparency transparency NN www-nature-com-2208 21 31 , , , www-nature-com-2208 21 32 reproducibility reproducibility NN www-nature-com-2208 21 33 , , , www-nature-com-2208 21 34 and and CC www-nature-com-2208 21 35 reusability reusability NN www-nature-com-2208 21 36 . . . www-nature-com-2208 22 1 There there EX www-nature-com-2208 22 2 are be VBP www-nature-com-2208 22 3 numerous numerous JJ www-nature-com-2208 22 4 and and CC www-nature-com-2208 22 5 diverse diverse JJ www-nature-com-2208 22 6 stakeholders stakeholder NNS www-nature-com-2208 22 7 who who WP www-nature-com-2208 22 8 stand stand VBP www-nature-com-2208 22 9 to to TO www-nature-com-2208 22 10 benefit benefit VB www-nature-com-2208 22 11 from from IN www-nature-com-2208 22 12 overcoming overcome VBG www-nature-com-2208 22 13 these these DT www-nature-com-2208 22 14 obstacles obstacle NNS www-nature-com-2208 22 15 : : : www-nature-com-2208 22 16 researchers researcher NNS www-nature-com-2208 22 17 wanting want VBG www-nature-com-2208 22 18 to to TO www-nature-com-2208 22 19 share share VB www-nature-com-2208 22 20 , , , www-nature-com-2208 22 21 get get VB www-nature-com-2208 22 22 credit credit NN www-nature-com-2208 22 23 , , , www-nature-com-2208 22 24 and and CC www-nature-com-2208 22 25 reuse reuse VB www-nature-com-2208 22 26 each each DT www-nature-com-2208 22 27 other other JJ www-nature-com-2208 22 28 ’s ’s POS www-nature-com-2208 22 29 data datum NNS www-nature-com-2208 22 30 and and CC www-nature-com-2208 22 31 interpretations interpretation NNS www-nature-com-2208 22 32 ; ; : www-nature-com-2208 22 33 professional professional JJ www-nature-com-2208 22 34 data data NN www-nature-com-2208 22 35 publishers publisher NNS www-nature-com-2208 22 36 offering offer VBG www-nature-com-2208 22 37 their -PRON- PRP$ www-nature-com-2208 22 38 services service NNS www-nature-com-2208 22 39 ; ; : www-nature-com-2208 22 40 software software NN www-nature-com-2208 22 41 and and CC www-nature-com-2208 22 42 tool tool NN www-nature-com-2208 22 43 - - HYPH www-nature-com-2208 22 44 builders builder NNS www-nature-com-2208 22 45 providing provide VBG www-nature-com-2208 22 46 data datum NNS www-nature-com-2208 22 47 analysis analysis NN www-nature-com-2208 22 48 and and CC www-nature-com-2208 22 49 processing processing NN www-nature-com-2208 22 50 services service NNS www-nature-com-2208 22 51 such such JJ www-nature-com-2208 22 52 as as IN www-nature-com-2208 22 53 reusable reusable JJ www-nature-com-2208 22 54 workflows workflow NNS www-nature-com-2208 22 55 ; ; : www-nature-com-2208 22 56 funding funding NN www-nature-com-2208 22 57 agencies agency NNS www-nature-com-2208 22 58 ( ( -LRB- www-nature-com-2208 22 59 private private JJ www-nature-com-2208 22 60 and and CC www-nature-com-2208 22 61 public public JJ www-nature-com-2208 22 62 ) ) -RRB- www-nature-com-2208 22 63 increasingly increasingly RB www-nature-com-2208 22 64 concerned concern VBN www-nature-com-2208 22 65 with with IN www-nature-com-2208 22 66 long long JJ www-nature-com-2208 22 67 - - HYPH www-nature-com-2208 22 68 term term NN www-nature-com-2208 22 69 data datum NNS www-nature-com-2208 22 70 stewardship stewardship NN www-nature-com-2208 22 71 ; ; : www-nature-com-2208 22 72 and and CC www-nature-com-2208 22 73 a a DT www-nature-com-2208 22 74 data data NN www-nature-com-2208 22 75 science science NN www-nature-com-2208 22 76 community community NN www-nature-com-2208 22 77 mining mining NN www-nature-com-2208 22 78 , , , www-nature-com-2208 22 79 integrating integrate VBG www-nature-com-2208 22 80 and and CC www-nature-com-2208 22 81 analysing analyse VBG www-nature-com-2208 22 82 new new JJ www-nature-com-2208 22 83 and and CC www-nature-com-2208 22 84 existing exist VBG www-nature-com-2208 22 85 data datum NNS www-nature-com-2208 22 86 to to TO www-nature-com-2208 22 87 advance advance VB www-nature-com-2208 22 88 discovery discovery NN www-nature-com-2208 22 89 . . . www-nature-com-2208 23 1 To to TO www-nature-com-2208 23 2 facilitate facilitate VB www-nature-com-2208 23 3 the the DT www-nature-com-2208 23 4 reading reading NN www-nature-com-2208 23 5 of of IN www-nature-com-2208 23 6 this this DT www-nature-com-2208 23 7 manuscript manuscript NN www-nature-com-2208 23 8 by by IN www-nature-com-2208 23 9 these these DT www-nature-com-2208 23 10 diverse diverse JJ www-nature-com-2208 23 11 stakeholders stakeholder NNS www-nature-com-2208 23 12 , , , www-nature-com-2208 23 13 we -PRON- PRP www-nature-com-2208 23 14 provide provide VBP www-nature-com-2208 23 15 definitions definition NNS www-nature-com-2208 23 16 for for IN www-nature-com-2208 23 17 common common JJ www-nature-com-2208 23 18 abbreviations abbreviation NNS www-nature-com-2208 23 19 in in IN www-nature-com-2208 23 20 Box Box NNP www-nature-com-2208 23 21 1 1 CD www-nature-com-2208 23 22 . . . www-nature-com-2208 24 1 Humans human NNS www-nature-com-2208 24 2 , , , www-nature-com-2208 24 3 however however RB www-nature-com-2208 24 4 , , , www-nature-com-2208 24 5 are be VBP www-nature-com-2208 24 6 not not RB www-nature-com-2208 24 7 the the DT www-nature-com-2208 24 8 only only JJ www-nature-com-2208 24 9 critical critical JJ www-nature-com-2208 24 10 stakeholders stakeholder NNS www-nature-com-2208 24 11 in in IN www-nature-com-2208 24 12 the the DT www-nature-com-2208 24 13 milieu milieu NN www-nature-com-2208 24 14 of of IN www-nature-com-2208 24 15 scientific scientific JJ www-nature-com-2208 24 16 data datum NNS www-nature-com-2208 24 17 . . . www-nature-com-2208 25 1 Similar similar JJ www-nature-com-2208 25 2 problems problem NNS www-nature-com-2208 25 3 are be VBP www-nature-com-2208 25 4 encountered encounter VBN www-nature-com-2208 25 5 by by IN www-nature-com-2208 25 6 the the DT www-nature-com-2208 25 7 applications application NNS www-nature-com-2208 25 8 and and CC www-nature-com-2208 25 9 computational computational JJ www-nature-com-2208 25 10 agents agent NNS www-nature-com-2208 25 11 that that WDT www-nature-com-2208 25 12 we -PRON- PRP www-nature-com-2208 25 13 task task VBP www-nature-com-2208 25 14 to to TO www-nature-com-2208 25 15 undertake undertake VB www-nature-com-2208 25 16 data data NN www-nature-com-2208 25 17 retrieval retrieval NN www-nature-com-2208 25 18 and and CC www-nature-com-2208 25 19 analysis analysis NN www-nature-com-2208 25 20 on on IN www-nature-com-2208 25 21 our -PRON- PRP$ www-nature-com-2208 25 22 behalf behalf NN www-nature-com-2208 25 23 . . . www-nature-com-2208 26 1 These these DT www-nature-com-2208 26 2 ‘ ' `` www-nature-com-2208 26 3 computational computational JJ www-nature-com-2208 26 4 stakeholders stakeholder NNS www-nature-com-2208 26 5 ’ ' '' www-nature-com-2208 26 6 are be VBP www-nature-com-2208 26 7 increasingly increasingly RB www-nature-com-2208 26 8 relevant relevant JJ www-nature-com-2208 26 9 , , , www-nature-com-2208 26 10 and and CC www-nature-com-2208 26 11 demand demand VB www-nature-com-2208 26 12 as as RB www-nature-com-2208 26 13 much much JJ www-nature-com-2208 26 14 , , , www-nature-com-2208 26 15 or or CC www-nature-com-2208 26 16 more more JJR www-nature-com-2208 26 17 , , , www-nature-com-2208 26 18 attention attention NN www-nature-com-2208 26 19 as as IN www-nature-com-2208 26 20 their -PRON- PRP$ www-nature-com-2208 26 21 importance importance NN www-nature-com-2208 26 22 grows grow VBZ www-nature-com-2208 26 23 . . . www-nature-com-2208 27 1 One one CD www-nature-com-2208 27 2 of of IN www-nature-com-2208 27 3 the the DT www-nature-com-2208 27 4 grand grand JJ www-nature-com-2208 27 5 challenges challenge NNS www-nature-com-2208 27 6 of of IN www-nature-com-2208 27 7 data data NN www-nature-com-2208 27 8 - - HYPH www-nature-com-2208 27 9 intensive intensive JJ www-nature-com-2208 27 10 science science NN www-nature-com-2208 27 11 , , , www-nature-com-2208 27 12 therefore therefore RB www-nature-com-2208 27 13 , , , www-nature-com-2208 27 14 is be VBZ www-nature-com-2208 27 15 to to TO www-nature-com-2208 27 16 improve improve VB www-nature-com-2208 27 17 knowledge knowledge NN www-nature-com-2208 27 18 discovery discovery NN www-nature-com-2208 27 19 through through IN www-nature-com-2208 27 20 assisting assist VBG www-nature-com-2208 27 21 both both DT www-nature-com-2208 27 22 humans human NNS www-nature-com-2208 27 23 , , , www-nature-com-2208 27 24 and and CC www-nature-com-2208 27 25 their -PRON- PRP$ www-nature-com-2208 27 26 computational computational JJ www-nature-com-2208 27 27 agents agent NNS www-nature-com-2208 27 28 , , , www-nature-com-2208 27 29 in in IN www-nature-com-2208 27 30 the the DT www-nature-com-2208 27 31 discovery discovery NN www-nature-com-2208 27 32 of of IN www-nature-com-2208 27 33 , , , www-nature-com-2208 27 34 access access NN www-nature-com-2208 27 35 to to IN www-nature-com-2208 27 36 , , , www-nature-com-2208 27 37 and and CC www-nature-com-2208 27 38 integration integration NN www-nature-com-2208 27 39 and and CC www-nature-com-2208 27 40 analysis analysis NN www-nature-com-2208 27 41 of of IN www-nature-com-2208 27 42 , , , www-nature-com-2208 27 43 task task NN www-nature-com-2208 27 44 - - HYPH www-nature-com-2208 27 45 appropriate appropriate JJ www-nature-com-2208 27 46 scientific scientific JJ www-nature-com-2208 27 47 data datum NNS www-nature-com-2208 27 48 and and CC www-nature-com-2208 27 49 other other JJ www-nature-com-2208 27 50 scholarly scholarly JJ www-nature-com-2208 27 51 digital digital JJ www-nature-com-2208 27 52 objects object NNS www-nature-com-2208 27 53 . . . www-nature-com-2208 28 1 For for IN www-nature-com-2208 28 2 certain certain JJ www-nature-com-2208 28 3 types type NNS www-nature-com-2208 28 4 of of IN www-nature-com-2208 28 5 important important JJ www-nature-com-2208 28 6 digital digital JJ www-nature-com-2208 28 7 objects object NNS www-nature-com-2208 28 8 , , , www-nature-com-2208 28 9 there there EX www-nature-com-2208 28 10 are be VBP www-nature-com-2208 28 11 well well RB www-nature-com-2208 28 12 - - HYPH www-nature-com-2208 28 13 curated curate VBN www-nature-com-2208 28 14 , , , www-nature-com-2208 28 15 deeply deeply RB www-nature-com-2208 28 16 - - HYPH www-nature-com-2208 28 17 integrated integrated JJ www-nature-com-2208 28 18 , , , www-nature-com-2208 28 19 special special JJ www-nature-com-2208 28 20 - - HYPH www-nature-com-2208 28 21 purpose purpose NN www-nature-com-2208 28 22 repositories repository NNS www-nature-com-2208 28 23 such such JJ www-nature-com-2208 28 24 as as IN www-nature-com-2208 28 25 Genbank3 Genbank3 NNP www-nature-com-2208 28 26 , , , www-nature-com-2208 28 27 Worldwide Worldwide NNP www-nature-com-2208 28 28 Protein Protein NNP www-nature-com-2208 28 29 Data Data NNPS www-nature-com-2208 28 30 Bank Bank NNP www-nature-com-2208 28 31 ( ( -LRB- www-nature-com-2208 28 32 wwPDB4 wwPDB4 NNP www-nature-com-2208 28 33 ) ) -RRB- www-nature-com-2208 28 34 , , , www-nature-com-2208 28 35 and and CC www-nature-com-2208 28 36 UniProt5 uniprot5 NN www-nature-com-2208 28 37 in in IN www-nature-com-2208 28 38 the the DT www-nature-com-2208 28 39 life life NN www-nature-com-2208 28 40 sciences science NNS www-nature-com-2208 28 41 ; ; : www-nature-com-2208 28 42 Space Space NNP www-nature-com-2208 28 43 Physics Physics NNP www-nature-com-2208 28 44 Data Data NNP www-nature-com-2208 28 45 Facility Facility NNP www-nature-com-2208 28 46 ( ( -LRB- www-nature-com-2208 28 47 SPDF SPDF NNP www-nature-com-2208 28 48 ; ; : www-nature-com-2208 28 49 http://spdf.gsfc.nasa.gov/ http://spdf.gsfc.nasa.gov/ NNP www-nature-com-2208 28 50 ) ) -RRB- www-nature-com-2208 28 51 and and CC www-nature-com-2208 28 52 Set Set NNP www-nature-com-2208 28 53 of of IN www-nature-com-2208 28 54 Identifications Identifications NNPS www-nature-com-2208 28 55 , , , www-nature-com-2208 28 56 Measurements Measurements NNPS www-nature-com-2208 28 57 and and CC www-nature-com-2208 28 58 Bibliography Bibliography NNP www-nature-com-2208 28 59 for for IN www-nature-com-2208 28 60 Astronomical Astronomical NNP www-nature-com-2208 28 61 Data Data NNP www-nature-com-2208 28 62 ( ( -LRB- www-nature-com-2208 28 63 SIMBAD6 SIMBAD6 '' www-nature-com-2208 28 64 ) ) -RRB- www-nature-com-2208 28 65 in in IN www-nature-com-2208 28 66 the the DT www-nature-com-2208 28 67 space space NN www-nature-com-2208 28 68 sciences science NNS www-nature-com-2208 28 69 . . . www-nature-com-2208 29 1 These these DT www-nature-com-2208 29 2 foundational foundational JJ www-nature-com-2208 29 3 and and CC www-nature-com-2208 29 4 critical critical JJ www-nature-com-2208 29 5 core core NN www-nature-com-2208 29 6 resources resource NNS www-nature-com-2208 29 7 are be VBP www-nature-com-2208 29 8 continuously continuously RB www-nature-com-2208 29 9 curating curate VBG www-nature-com-2208 29 10 and and CC www-nature-com-2208 29 11 capturing capture VBG www-nature-com-2208 29 12 high high JJ www-nature-com-2208 29 13 - - HYPH www-nature-com-2208 29 14 value value NN www-nature-com-2208 29 15 reference reference NN www-nature-com-2208 29 16 datasets dataset NNS www-nature-com-2208 29 17 and and CC www-nature-com-2208 29 18 fine fine RB www-nature-com-2208 29 19 - - HYPH www-nature-com-2208 29 20 tuning tune VBG www-nature-com-2208 29 21 them -PRON- PRP www-nature-com-2208 29 22 to to TO www-nature-com-2208 29 23 enhance enhance VB www-nature-com-2208 29 24 scholarly scholarly JJ www-nature-com-2208 29 25 output output NN www-nature-com-2208 29 26 , , , www-nature-com-2208 29 27 provide provide VB www-nature-com-2208 29 28 support support NN www-nature-com-2208 29 29 for for IN www-nature-com-2208 29 30 both both CC www-nature-com-2208 29 31 human human JJ www-nature-com-2208 29 32 and and CC www-nature-com-2208 29 33 mechanical mechanical JJ www-nature-com-2208 29 34 users user NNS www-nature-com-2208 29 35 , , , www-nature-com-2208 29 36 and and CC www-nature-com-2208 29 37 provide provide VB www-nature-com-2208 29 38 extensive extensive JJ www-nature-com-2208 29 39 tooling tooling NN www-nature-com-2208 29 40 to to TO www-nature-com-2208 29 41 access access VB www-nature-com-2208 29 42 their -PRON- PRP$ www-nature-com-2208 29 43 content content NN www-nature-com-2208 29 44 in in IN www-nature-com-2208 29 45 rich rich JJ www-nature-com-2208 29 46 , , , www-nature-com-2208 29 47 dynamic dynamic JJ www-nature-com-2208 29 48 ways way NNS www-nature-com-2208 29 49 . . . www-nature-com-2208 30 1 However however RB www-nature-com-2208 30 2 , , , www-nature-com-2208 30 3 not not RB www-nature-com-2208 30 4 all all DT www-nature-com-2208 30 5 datasets dataset NNS www-nature-com-2208 30 6 or or CC www-nature-com-2208 30 7 even even RB www-nature-com-2208 30 8 data data NN www-nature-com-2208 30 9 types type NNS www-nature-com-2208 30 10 can can MD www-nature-com-2208 30 11 be be VB www-nature-com-2208 30 12 captured capture VBN www-nature-com-2208 30 13 by by RB www-nature-com-2208 30 14 , , , www-nature-com-2208 30 15 or or CC www-nature-com-2208 30 16 submitted submit VBN www-nature-com-2208 30 17 to to IN www-nature-com-2208 30 18 , , , www-nature-com-2208 30 19 these these DT www-nature-com-2208 30 20 repositories repository NNS www-nature-com-2208 30 21 . . . www-nature-com-2208 31 1 Many many JJ www-nature-com-2208 31 2 important important JJ www-nature-com-2208 31 3 datasets dataset NNS www-nature-com-2208 31 4 emerging emerge VBG www-nature-com-2208 31 5 from from IN www-nature-com-2208 31 6 traditional traditional JJ www-nature-com-2208 31 7 , , , www-nature-com-2208 31 8 low low JJ www-nature-com-2208 31 9 - - HYPH www-nature-com-2208 31 10 throughput throughput NN www-nature-com-2208 31 11 bench bench NN www-nature-com-2208 31 12 science science NN www-nature-com-2208 31 13 do do VBP www-nature-com-2208 31 14 n’t not RB www-nature-com-2208 31 15 fit fit VB www-nature-com-2208 31 16 in in IN www-nature-com-2208 31 17 the the DT www-nature-com-2208 31 18 data datum NNS www-nature-com-2208 31 19 models model NNS www-nature-com-2208 31 20 of of IN www-nature-com-2208 31 21 these these DT www-nature-com-2208 31 22 special special JJ www-nature-com-2208 31 23 - - HYPH www-nature-com-2208 31 24 purpose purpose NN www-nature-com-2208 31 25 repositories repository NNS www-nature-com-2208 31 26 , , , www-nature-com-2208 31 27 yet yet CC www-nature-com-2208 31 28 these these DT www-nature-com-2208 31 29 datasets dataset NNS www-nature-com-2208 31 30 are be VBP www-nature-com-2208 31 31 no no RB www-nature-com-2208 31 32 less less RBR www-nature-com-2208 31 33 important important JJ www-nature-com-2208 31 34 with with IN www-nature-com-2208 31 35 respect respect NN www-nature-com-2208 31 36 to to IN www-nature-com-2208 31 37 integrative integrative JJ www-nature-com-2208 31 38 research research NN www-nature-com-2208 31 39 , , , www-nature-com-2208 31 40 reproducibility reproducibility NN www-nature-com-2208 31 41 , , , www-nature-com-2208 31 42 and and CC www-nature-com-2208 31 43 reuse reuse VB www-nature-com-2208 31 44 in in IN www-nature-com-2208 31 45 general general JJ www-nature-com-2208 31 46 . . . www-nature-com-2208 32 1 Apparently apparently RB www-nature-com-2208 32 2 in in IN www-nature-com-2208 32 3 response response NN www-nature-com-2208 32 4 to to IN www-nature-com-2208 32 5 this this DT www-nature-com-2208 32 6 , , , www-nature-com-2208 32 7 we -PRON- PRP www-nature-com-2208 32 8 see see VBP www-nature-com-2208 32 9 the the DT www-nature-com-2208 32 10 emergence emergence NN www-nature-com-2208 32 11 of of IN www-nature-com-2208 32 12 numerous numerous JJ www-nature-com-2208 32 13 general general JJ www-nature-com-2208 32 14 - - HYPH www-nature-com-2208 32 15 purpose purpose NN www-nature-com-2208 32 16 data datum NNS www-nature-com-2208 32 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NNP www-nature-com-2208 32 42 , , , www-nature-com-2208 32 43 FigShare FigShare NNP www-nature-com-2208 32 44 ( ( -LRB- www-nature-com-2208 32 45 http://figshare.com http://figshare.com ADD www-nature-com-2208 32 46 ) ) -RRB- www-nature-com-2208 32 47 , , , www-nature-com-2208 32 48 Dryad8 Dryad8 NNP www-nature-com-2208 32 49 , , , www-nature-com-2208 32 50 Mendeley Mendeley NNP www-nature-com-2208 32 51 Data Data NNP www-nature-com-2208 32 52 ( ( -LRB- www-nature-com-2208 32 53 https://data.mendeley.com/ https://data.mendeley.com/ NNP www-nature-com-2208 32 54 ) ) -RRB- www-nature-com-2208 32 55 , , , www-nature-com-2208 32 56 Zenodo Zenodo NNP www-nature-com-2208 32 57 ( ( -LRB- www-nature-com-2208 32 58 http://zenodo.org/ http://zenodo.org/ NNP www-nature-com-2208 32 59 ) ) -RRB- www-nature-com-2208 32 60 , , , www-nature-com-2208 32 61 DataHub DataHub NNP www-nature-com-2208 32 62 ( ( -LRB- www-nature-com-2208 32 63 http://datahub.io http://datahub.io NNP www-nature-com-2208 32 64 ) ) -RRB- www-nature-com-2208 32 65 , , , www-nature-com-2208 32 66 DANS DANS NNP www-nature-com-2208 32 67 ( ( -LRB- www-nature-com-2208 32 68 http://www.dans.knaw.nl/ http://www.dans.knaw.nl/ NNP www-nature-com-2208 32 69 ) ) -RRB- www-nature-com-2208 32 70 , , , www-nature-com-2208 32 71 and and CC www-nature-com-2208 32 72 EUDat9 EUDat9 NNP www-nature-com-2208 32 73 . . . www-nature-com-2208 33 1 Such such JJ www-nature-com-2208 33 2 repositories repository NNS www-nature-com-2208 33 3 accept accept VBP www-nature-com-2208 33 4 a a DT www-nature-com-2208 33 5 wide wide JJ www-nature-com-2208 33 6 range range NN www-nature-com-2208 33 7 of of IN www-nature-com-2208 33 8 data datum NNS www-nature-com-2208 33 9 types type NNS www-nature-com-2208 33 10 in in IN www-nature-com-2208 33 11 a a DT www-nature-com-2208 33 12 wide wide JJ www-nature-com-2208 33 13 variety variety NN www-nature-com-2208 33 14 of of IN www-nature-com-2208 33 15 formats format NNS www-nature-com-2208 33 16 , , , www-nature-com-2208 33 17 generally generally RB www-nature-com-2208 33 18 do do VBP www-nature-com-2208 33 19 not not RB www-nature-com-2208 33 20 attempt attempt VB www-nature-com-2208 33 21 to to TO www-nature-com-2208 33 22 integrate integrate VB www-nature-com-2208 33 23 or or CC www-nature-com-2208 33 24 harmonize harmonize VB www-nature-com-2208 33 25 the the DT www-nature-com-2208 33 26 deposited deposit VBN www-nature-com-2208 33 27 data datum NNS www-nature-com-2208 33 28 , , , www-nature-com-2208 33 29 and and CC www-nature-com-2208 33 30 place place VB www-nature-com-2208 33 31 few few JJ www-nature-com-2208 33 32 restrictions restriction NNS www-nature-com-2208 33 33 ( ( -LRB- www-nature-com-2208 33 34 or or CC www-nature-com-2208 33 35 requirements requirement NNS www-nature-com-2208 33 36 ) ) -RRB- www-nature-com-2208 33 37 on on IN www-nature-com-2208 33 38 the the DT www-nature-com-2208 33 39 descriptors descriptor NNS www-nature-com-2208 33 40 of of IN www-nature-com-2208 33 41 the the DT www-nature-com-2208 33 42 data data NN www-nature-com-2208 33 43 deposition deposition NN www-nature-com-2208 33 44 . . . www-nature-com-2208 34 1 The the DT www-nature-com-2208 34 2 resulting result VBG www-nature-com-2208 34 3 data data NN www-nature-com-2208 34 4 ecosystem ecosystem NN www-nature-com-2208 34 5 , , , www-nature-com-2208 34 6 therefore therefore RB www-nature-com-2208 34 7 , , , www-nature-com-2208 34 8 appears appear VBZ www-nature-com-2208 34 9 to to TO www-nature-com-2208 34 10 be be VB www-nature-com-2208 34 11 moving move VBG www-nature-com-2208 34 12 away away RB www-nature-com-2208 34 13 from from IN www-nature-com-2208 34 14 centralization centralization NN www-nature-com-2208 34 15 , , , www-nature-com-2208 34 16 is be VBZ www-nature-com-2208 34 17 becoming become VBG www-nature-com-2208 34 18 more more RBR www-nature-com-2208 34 19 diverse diverse JJ www-nature-com-2208 34 20 , , , www-nature-com-2208 34 21 and and CC www-nature-com-2208 34 22 less less RBR www-nature-com-2208 34 23 integrated integrated JJ www-nature-com-2208 34 24 , , , www-nature-com-2208 34 25 thereby thereby RB www-nature-com-2208 34 26 exacerbating exacerbate VBG www-nature-com-2208 34 27 the the DT www-nature-com-2208 34 28 discovery discovery NN www-nature-com-2208 34 29 and and CC www-nature-com-2208 34 30 re re NN www-nature-com-2208 34 31 - - JJ www-nature-com-2208 34 32 usability usability JJ www-nature-com-2208 34 33 problem problem NN www-nature-com-2208 34 34 for for IN www-nature-com-2208 34 35 both both CC www-nature-com-2208 34 36 human human JJ www-nature-com-2208 34 37 and and CC www-nature-com-2208 34 38 computational computational JJ www-nature-com-2208 34 39 stakeholders stakeholder NNS www-nature-com-2208 34 40 . . . www-nature-com-2208 35 1 A a DT www-nature-com-2208 35 2 specific specific JJ www-nature-com-2208 35 3 example example NN www-nature-com-2208 35 4 of of IN www-nature-com-2208 35 5 these these DT www-nature-com-2208 35 6 obstacles obstacle NNS www-nature-com-2208 35 7 could could MD www-nature-com-2208 35 8 be be VB www-nature-com-2208 35 9 imagined imagine VBN www-nature-com-2208 35 10 in in IN www-nature-com-2208 35 11 the the DT www-nature-com-2208 35 12 domain domain NN www-nature-com-2208 35 13 of of IN www-nature-com-2208 35 14 gene gene NN www-nature-com-2208 35 15 regulation regulation NN www-nature-com-2208 35 16 and and CC www-nature-com-2208 35 17 expression expression NN www-nature-com-2208 35 18 analysis analysis NN www-nature-com-2208 35 19 . . . www-nature-com-2208 36 1 Suppose suppose VB www-nature-com-2208 36 2 a a DT www-nature-com-2208 36 3 researcher researcher NN www-nature-com-2208 36 4 has have VBZ www-nature-com-2208 36 5 generated generate VBN www-nature-com-2208 36 6 a a DT www-nature-com-2208 36 7 dataset dataset NN www-nature-com-2208 36 8 of of IN www-nature-com-2208 36 9 differentially differentially RB www-nature-com-2208 36 10 - - HYPH www-nature-com-2208 36 11 selected select VBN www-nature-com-2208 36 12 polyadenylation polyadenylation NN www-nature-com-2208 36 13 sites site NNS www-nature-com-2208 36 14 in in IN www-nature-com-2208 36 15 a a DT www-nature-com-2208 36 16 non non JJ www-nature-com-2208 36 17 - - JJ www-nature-com-2208 36 18 model model JJ www-nature-com-2208 36 19 pathogenic pathogenic JJ www-nature-com-2208 36 20 organism organism NN www-nature-com-2208 36 21 grown grow VBN www-nature-com-2208 36 22 under under IN www-nature-com-2208 36 23 a a DT www-nature-com-2208 36 24 variety variety NN www-nature-com-2208 36 25 of of IN www-nature-com-2208 36 26 environmental environmental JJ www-nature-com-2208 36 27 conditions condition NNS www-nature-com-2208 36 28 that that WDT www-nature-com-2208 36 29 stimulate stimulate VBP www-nature-com-2208 36 30 its -PRON- PRP$ www-nature-com-2208 36 31 pathogenic pathogenic JJ www-nature-com-2208 36 32 state state NN www-nature-com-2208 36 33 . . . www-nature-com-2208 37 1 The the DT www-nature-com-2208 37 2 researcher researcher NN www-nature-com-2208 37 3 is be VBZ www-nature-com-2208 37 4 interested interested JJ www-nature-com-2208 37 5 in in IN www-nature-com-2208 37 6 comparing compare VBG www-nature-com-2208 37 7 the the DT www-nature-com-2208 37 8 alternatively alternatively RB www-nature-com-2208 37 9 - - HYPH www-nature-com-2208 37 10 polyadenylated polyadenylate VBN www-nature-com-2208 37 11 genes gene NNS www-nature-com-2208 37 12 in in IN www-nature-com-2208 37 13 this this DT www-nature-com-2208 37 14 local local JJ www-nature-com-2208 37 15 dataset dataset NN www-nature-com-2208 37 16 , , , www-nature-com-2208 37 17 to to IN www-nature-com-2208 37 18 other other JJ www-nature-com-2208 37 19 examples example NNS www-nature-com-2208 37 20 of of IN www-nature-com-2208 37 21 alternative alternative JJ www-nature-com-2208 37 22 - - HYPH www-nature-com-2208 37 23 polyadenylation polyadenylation NN www-nature-com-2208 37 24 , , , www-nature-com-2208 37 25 and and CC www-nature-com-2208 37 26 the the DT www-nature-com-2208 37 27 expression expression NN www-nature-com-2208 37 28 levels level NNS www-nature-com-2208 37 29 of of IN www-nature-com-2208 37 30 these these DT www-nature-com-2208 37 31 genes gene NNS www-nature-com-2208 37 32 — — : www-nature-com-2208 37 33 both both DT www-nature-com-2208 37 34 in in IN www-nature-com-2208 37 35 this this DT www-nature-com-2208 37 36 organism organism NN www-nature-com-2208 37 37 and and CC www-nature-com-2208 37 38 related related JJ www-nature-com-2208 37 39 model model NN www-nature-com-2208 37 40 organisms organism NNS www-nature-com-2208 37 41 — — : www-nature-com-2208 37 42 during during IN www-nature-com-2208 37 43 the the DT www-nature-com-2208 37 44 infection infection NN www-nature-com-2208 37 45 process process NN www-nature-com-2208 37 46 . . . www-nature-com-2208 38 1 Given give VBN www-nature-com-2208 38 2 that that IN www-nature-com-2208 38 3 there there EX www-nature-com-2208 38 4 is be VBZ www-nature-com-2208 38 5 no no DT www-nature-com-2208 38 6 special special JJ www-nature-com-2208 38 7 - - HYPH www-nature-com-2208 38 8 purpose purpose NN www-nature-com-2208 38 9 archive archive NN www-nature-com-2208 38 10 for for IN www-nature-com-2208 38 11 differential differential NN www-nature-com-2208 38 12 polyadenylation polyadenylation NN www-nature-com-2208 38 13 data datum NNS www-nature-com-2208 38 14 , , , www-nature-com-2208 38 15 and and CC www-nature-com-2208 38 16 no no DT www-nature-com-2208 38 17 model model NN www-nature-com-2208 38 18 organism organism NN www-nature-com-2208 38 19 database database NN www-nature-com-2208 38 20 for for IN www-nature-com-2208 38 21 this this DT www-nature-com-2208 38 22 pathogen pathogen NN www-nature-com-2208 38 23 , , , www-nature-com-2208 38 24 where where WRB www-nature-com-2208 38 25 does do VBZ www-nature-com-2208 38 26 the the DT www-nature-com-2208 38 27 researcher researcher NN www-nature-com-2208 38 28 begin begin VB www-nature-com-2208 38 29 ? ? . www-nature-com-2208 39 1 We -PRON- PRP www-nature-com-2208 39 2 will will MD www-nature-com-2208 39 3 consider consider VB www-nature-com-2208 39 4 the the DT www-nature-com-2208 39 5 current current JJ www-nature-com-2208 39 6 approach approach NN www-nature-com-2208 39 7 to to IN www-nature-com-2208 39 8 this this DT www-nature-com-2208 39 9 problem problem NN www-nature-com-2208 39 10 from from IN www-nature-com-2208 39 11 a a DT www-nature-com-2208 39 12 variety variety NN www-nature-com-2208 39 13 of of IN www-nature-com-2208 39 14 data datum NNS www-nature-com-2208 39 15 discovery discovery NN www-nature-com-2208 39 16 and and CC www-nature-com-2208 39 17 integration integration NN www-nature-com-2208 39 18 perspectives perspective NNS www-nature-com-2208 39 19 . . . www-nature-com-2208 40 1 If if IN www-nature-com-2208 40 2 the the DT www-nature-com-2208 40 3 desired desire VBN www-nature-com-2208 40 4 datasets dataset NNS www-nature-com-2208 40 5 existed exist VBD www-nature-com-2208 40 6 , , , www-nature-com-2208 40 7 where where WRB www-nature-com-2208 40 8 might may MD www-nature-com-2208 40 9 they -PRON- PRP www-nature-com-2208 40 10 have have VB www-nature-com-2208 40 11 been be VBN www-nature-com-2208 40 12 published publish VBN www-nature-com-2208 40 13 , , , www-nature-com-2208 40 14 and and CC www-nature-com-2208 40 15 how how WRB www-nature-com-2208 40 16 would would MD www-nature-com-2208 40 17 one one PRP www-nature-com-2208 40 18 begin begin VB www-nature-com-2208 40 19 to to TO www-nature-com-2208 40 20 search search VB www-nature-com-2208 40 21 for for IN www-nature-com-2208 40 22 them -PRON- PRP www-nature-com-2208 40 23 , , , www-nature-com-2208 40 24 using use VBG www-nature-com-2208 40 25 what what WDT www-nature-com-2208 40 26 search search NN www-nature-com-2208 40 27 tools tool NNS www-nature-com-2208 40 28 ? ? . www-nature-com-2208 41 1 The the DT www-nature-com-2208 41 2 desired desire VBN www-nature-com-2208 41 3 search search NN www-nature-com-2208 41 4 would would MD www-nature-com-2208 41 5 need need VB www-nature-com-2208 41 6 to to TO www-nature-com-2208 41 7 filter filter VB www-nature-com-2208 41 8 based base VBN www-nature-com-2208 41 9 on on IN www-nature-com-2208 41 10 specific specific JJ www-nature-com-2208 41 11 species specie NNS www-nature-com-2208 41 12 , , , www-nature-com-2208 41 13 specific specific JJ www-nature-com-2208 41 14 tissues tissue NNS www-nature-com-2208 41 15 , , , www-nature-com-2208 41 16 specific specific JJ www-nature-com-2208 41 17 types type NNS www-nature-com-2208 41 18 of of IN www-nature-com-2208 41 19 data datum NNS www-nature-com-2208 41 20 ( ( -LRB- www-nature-com-2208 41 21 Poly Poly NNP www-nature-com-2208 41 22 - - HYPH www-nature-com-2208 41 23 A A NNP www-nature-com-2208 41 24 , , , www-nature-com-2208 41 25 microarray microarray JJ www-nature-com-2208 41 26 , , , 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www-nature-com-2208 41 52 , , , www-nature-com-2208 41 53 and and CC www-nature-com-2208 41 54 if if IN www-nature-com-2208 41 55 so so RB www-nature-com-2208 41 56 , , , www-nature-com-2208 41 57 what what WDT www-nature-com-2208 41 58 formats format NNS www-nature-com-2208 41 59 is be VBZ www-nature-com-2208 41 60 it -PRON- PRP www-nature-com-2208 41 61 in in RB www-nature-com-2208 41 62 , , , www-nature-com-2208 41 63 is be VBZ www-nature-com-2208 41 64 it -PRON- PRP www-nature-com-2208 41 65 searchable searchable JJ www-nature-com-2208 41 66 , , , www-nature-com-2208 41 67 and and CC www-nature-com-2208 41 68 how how WRB www-nature-com-2208 41 69 ? ? . www-nature-com-2208 42 1 Once once IN www-nature-com-2208 42 2 the the DT www-nature-com-2208 42 3 data data NN www-nature-com-2208 42 4 is be VBZ www-nature-com-2208 42 5 discovered discover VBN www-nature-com-2208 42 6 , , , www-nature-com-2208 42 7 can can MD www-nature-com-2208 42 8 it -PRON- PRP www-nature-com-2208 42 9 be be VB www-nature-com-2208 42 10 downloaded download VBN www-nature-com-2208 42 11 ? ? . www-nature-com-2208 43 1 In in IN www-nature-com-2208 43 2 what what WP www-nature-com-2208 43 3 format(s format(s NNP www-nature-com-2208 43 4 ) ) -RRB- www-nature-com-2208 43 5 ? ? . www-nature-com-2208 44 1 Can Can MD www-nature-com-2208 44 2 that that DT www-nature-com-2208 44 3 format format NN www-nature-com-2208 44 4 be be VB www-nature-com-2208 44 5 easily easily RB www-nature-com-2208 44 6 integrated integrate VBN www-nature-com-2208 44 7 with with IN www-nature-com-2208 44 8 private private JJ www-nature-com-2208 44 9 in in IN www-nature-com-2208 44 10 - - HYPH www-nature-com-2208 44 11 house house NN www-nature-com-2208 44 12 data datum NNS www-nature-com-2208 44 13 ( ( -LRB- www-nature-com-2208 44 14 the the DT www-nature-com-2208 44 15 local local JJ www-nature-com-2208 44 16 dataset dataset NN www-nature-com-2208 44 17 of of IN www-nature-com-2208 44 18 alternative alternative JJ 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www-nature-com-2208 44 43 ? ? . www-nature-com-2208 45 1 Can Can MD www-nature-com-2208 45 2 this this DT www-nature-com-2208 45 3 integration integration NN www-nature-com-2208 45 4 be be VB www-nature-com-2208 45 5 done do VBN www-nature-com-2208 45 6 automatically automatically RB www-nature-com-2208 45 7 to to TO www-nature-com-2208 45 8 save save VB www-nature-com-2208 45 9 time time NN www-nature-com-2208 45 10 and and CC www-nature-com-2208 45 11 avoid avoid VB www-nature-com-2208 45 12 copy copy NN www-nature-com-2208 45 13 / / SYM www-nature-com-2208 45 14 paste paste NN www-nature-com-2208 45 15 errors error NNS www-nature-com-2208 45 16 ? ? . www-nature-com-2208 46 1 Does do VBZ www-nature-com-2208 46 2 the the DT www-nature-com-2208 46 3 researcher researcher NN www-nature-com-2208 46 4 have have VB www-nature-com-2208 46 5 permission permission NN www-nature-com-2208 46 6 to to TO www-nature-com-2208 46 7 use use VB www-nature-com-2208 46 8 the the DT www-nature-com-2208 46 9 data datum NNS www-nature-com-2208 46 10 from from IN www-nature-com-2208 46 11 these these DT www-nature-com-2208 46 12 third third JJ www-nature-com-2208 46 13 - - HYPH www-nature-com-2208 46 14 party party NN www-nature-com-2208 46 15 researchers researcher NNS www-nature-com-2208 46 16 , , , www-nature-com-2208 46 17 under under IN www-nature-com-2208 46 18 what what WDT www-nature-com-2208 46 19 license license NN www-nature-com-2208 46 20 conditions condition NNS www-nature-com-2208 46 21 , , , www-nature-com-2208 46 22 and and CC www-nature-com-2208 46 23 who who WP www-nature-com-2208 46 24 should should MD www-nature-com-2208 46 25 be be VB www-nature-com-2208 46 26 cited cite VBN www-nature-com-2208 46 27 if if IN www-nature-com-2208 46 28 a a DT www-nature-com-2208 46 29 data data NN www-nature-com-2208 46 30 - - HYPH www-nature-com-2208 46 31 point point NN www-nature-com-2208 46 32 is be VBZ www-nature-com-2208 46 33 re re JJ www-nature-com-2208 46 34 - - VBN www-nature-com-2208 46 35 used use VBN www-nature-com-2208 46 36 ? ? . www-nature-com-2208 47 1 Questions question NNS www-nature-com-2208 47 2 such such JJ www-nature-com-2208 47 3 as as IN www-nature-com-2208 47 4 these these DT www-nature-com-2208 47 5 highlight highlight VBP www-nature-com-2208 47 6 some some DT www-nature-com-2208 47 7 of of IN www-nature-com-2208 47 8 the the DT www-nature-com-2208 47 9 barriers barrier NNS www-nature-com-2208 47 10 to to IN www-nature-com-2208 47 11 data datum NNS www-nature-com-2208 47 12 discovery discovery NN www-nature-com-2208 47 13 and and CC www-nature-com-2208 47 14 reuse reuse VB www-nature-com-2208 47 15 , , , www-nature-com-2208 47 16 not not RB www-nature-com-2208 47 17 only only RB www-nature-com-2208 47 18 for for IN www-nature-com-2208 47 19 humans human NNS www-nature-com-2208 47 20 , , , www-nature-com-2208 47 21 but but CC www-nature-com-2208 47 22 even even RB www-nature-com-2208 47 23 more more RBR www-nature-com-2208 47 24 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NNP www-nature-com-2208 47 49 . . . www-nature-com-2208 48 1 The the DT www-nature-com-2208 48 2 reason reason NN www-nature-com-2208 48 3 that that IN www-nature-com-2208 48 4 we -PRON- PRP www-nature-com-2208 48 5 often often RB www-nature-com-2208 48 6 need need VBP www-nature-com-2208 48 7 several several JJ www-nature-com-2208 48 8 weeks week NNS www-nature-com-2208 48 9 ( ( -LRB- www-nature-com-2208 48 10 or or CC www-nature-com-2208 48 11 months month NNS www-nature-com-2208 48 12 ) ) -RRB- www-nature-com-2208 48 13 of of IN www-nature-com-2208 48 14 specialist specialist JJ www-nature-com-2208 48 15 technical technical JJ www-nature-com-2208 48 16 effort effort NN www-nature-com-2208 48 17 to to TO www-nature-com-2208 48 18 gather gather VB www-nature-com-2208 48 19 the the DT www-nature-com-2208 48 20 data datum NNS www-nature-com-2208 48 21 necessary necessary JJ www-nature-com-2208 48 22 to to TO www-nature-com-2208 48 23 answer answer VB www-nature-com-2208 48 24 such such 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50 30 — — : www-nature-com-2208 50 31 and and CC www-nature-com-2208 50 32 more more RBR www-nature-com-2208 50 33 importantly importantly RB www-nature-com-2208 50 34 , , , www-nature-com-2208 50 35 the the DT www-nature-com-2208 50 36 impact impact NN www-nature-com-2208 50 37 of of IN www-nature-com-2208 50 38 the the DT www-nature-com-2208 50 39 publication publication NN www-nature-com-2208 50 40 — — : www-nature-com-2208 50 41 is be VBZ www-nature-com-2208 50 42 a a DT www-nature-com-2208 50 43 function function NN www-nature-com-2208 50 44 of of IN www-nature-com-2208 50 45 its -PRON- PRP$ www-nature-com-2208 50 46 ability ability NN www-nature-com-2208 50 47 to to TO www-nature-com-2208 50 48 be be VB www-nature-com-2208 50 49 accurately accurately RB www-nature-com-2208 50 50 and and CC www-nature-com-2208 50 51 appropriately appropriately RB www-nature-com-2208 50 52 found find VBN www-nature-com-2208 50 53 , , , www-nature-com-2208 50 54 re re VB www-nature-com-2208 50 55 - - VBN www-nature-com-2208 50 56 used use VBN www-nature-com-2208 50 57 , , , www-nature-com-2208 50 58 and and CC www-nature-com-2208 50 59 cited cite VBN www-nature-com-2208 50 60 over over IN www-nature-com-2208 50 61 time time NN www-nature-com-2208 50 62 , , , www-nature-com-2208 50 63 by by IN www-nature-com-2208 50 64 all all DT www-nature-com-2208 50 65 stakeholders stakeholder NNS www-nature-com-2208 50 66 , , , www-nature-com-2208 50 67 both both CC www-nature-com-2208 50 68 human human JJ www-nature-com-2208 50 69 and and CC www-nature-com-2208 50 70 mechanical mechanical JJ www-nature-com-2208 50 71 . . . www-nature-com-2208 51 1 With with IN www-nature-com-2208 51 2 this this DT www-nature-com-2208 51 3 goal goal NN www-nature-com-2208 51 4 in in IN www-nature-com-2208 51 5 - - HYPH www-nature-com-2208 51 6 mind mind NN www-nature-com-2208 51 7 , , , www-nature-com-2208 51 8 a a DT www-nature-com-2208 51 9 workshop workshop NN www-nature-com-2208 51 10 was be VBD 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60 6 for for IN www-nature-com-2208 60 7 retrieval retrieval NN www-nature-com-2208 60 8 of of IN www-nature-com-2208 60 9 metadata metadata NN www-nature-com-2208 60 10 about about IN www-nature-com-2208 60 11 the the DT www-nature-com-2208 60 12 object object NN www-nature-com-2208 60 13 , , , www-nature-com-2208 60 14 and and CC www-nature-com-2208 60 15 generally generally RB www-nature-com-2208 60 16 a a DT www-nature-com-2208 60 17 means means NN www-nature-com-2208 60 18 to to TO www-nature-com-2208 60 19 access access VB www-nature-com-2208 60 20 the the DT www-nature-com-2208 60 21 data datum NNS www-nature-com-2208 60 22 object object VBP www-nature-com-2208 60 23 itself -PRON- PRP www-nature-com-2208 60 24 . . . www-nature-com-2208 61 1 FAIR FAIR NNP www-nature-com-2208 61 2 — — : www-nature-com-2208 61 3 Findable findable JJ www-nature-com-2208 61 4 , , , www-nature-com-2208 61 5 Accessible accessible JJ www-nature-com-2208 61 6 , , , www-nature-com-2208 61 7 Interoperable 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www-nature-com-2208 62 22 research research NN www-nature-com-2208 62 23 funders funder NNS www-nature-com-2208 62 24 that that WDT www-nature-com-2208 62 25 has have VBZ www-nature-com-2208 62 26 arisen arise VBN www-nature-com-2208 62 27 organically organically RB www-nature-com-2208 62 28 to to TO www-nature-com-2208 62 29 help help VB www-nature-com-2208 62 30 facilitate facilitate VB www-nature-com-2208 62 31 the the DT www-nature-com-2208 62 32 change change NN www-nature-com-2208 62 33 toward toward IN www-nature-com-2208 62 34 improved improved JJ www-nature-com-2208 62 35 knowledge knowledge NN www-nature-com-2208 62 36 creation creation NN www-nature-com-2208 62 37 and and CC www-nature-com-2208 62 38 sharing sharing NN www-nature-com-2208 62 39 , , , www-nature-com-2208 62 40 initiated initiate VBN www-nature-com-2208 62 41 in in IN www-nature-com-2208 62 42 2011 2011 CD www-nature-com-2208 62 43 . . . www-nature-com-2208 63 1 Interoperability interoperability NN www-nature-com-2208 63 2 — — : www-nature-com-2208 63 3 the the DT www-nature-com-2208 63 4 ability ability NN www-nature-com-2208 63 5 of of IN www-nature-com-2208 63 6 data datum NNS www-nature-com-2208 63 7 or or CC www-nature-com-2208 63 8 tools tool NNS www-nature-com-2208 63 9 from from IN www-nature-com-2208 63 10 non non JJ www-nature-com-2208 63 11 - - JJ www-nature-com-2208 63 12 cooperating cooperating JJ www-nature-com-2208 63 13 resources resource NNS www-nature-com-2208 63 14 to to TO www-nature-com-2208 63 15 integrate integrate VB www-nature-com-2208 63 16 or or CC www-nature-com-2208 63 17 work work VB www-nature-com-2208 63 18 together together RB www-nature-com-2208 63 19 with with IN www-nature-com-2208 63 20 minimal minimal JJ www-nature-com-2208 63 21 effort effort NN www-nature-com-2208 63 22 . . . www-nature-com-2208 64 1 JDDCP JDDCP NNP www-nature-com-2208 64 2 — — : www-nature-com-2208 64 3 Joint Joint NNP www-nature-com-2208 64 4 Declaration Declaration NNP www-nature-com-2208 64 5 of of IN www-nature-com-2208 64 6 Data Data NNP www-nature-com-2208 64 7 Citation Citation NNP www-nature-com-2208 64 8 Principles Principles NNPS www-nature-com-2208 64 9 ; ; : www-nature-com-2208 64 10 Acknowledging acknowledge VBG www-nature-com-2208 64 11 data datum NNS www-nature-com-2208 64 12 as as IN www-nature-com-2208 64 13 a a DT www-nature-com-2208 64 14 first first JJ www-nature-com-2208 64 15 - - HYPH www-nature-com-2208 64 16 class class NN www-nature-com-2208 64 17 research research NN www-nature-com-2208 64 18 output output NN www-nature-com-2208 64 19 , , , www-nature-com-2208 64 20 and and CC www-nature-com-2208 64 21 to to TO www-nature-com-2208 64 22 support support VB www-nature-com-2208 64 23 good good JJ www-nature-com-2208 64 24 research research NN www-nature-com-2208 64 25 practices practice NNS www-nature-com-2208 64 26 around around IN www-nature-com-2208 64 27 data datum NNS www-nature-com-2208 64 28 re re NN www-nature-com-2208 64 29 - - NN www-nature-com-2208 64 30 use use VBP www-nature-com-2208 64 31 , , , www-nature-com-2208 64 32 JDDCP JDDCP NNP www-nature-com-2208 64 33 proposes propose VBZ www-nature-com-2208 64 34 a a DT www-nature-com-2208 64 35 set set NN www-nature-com-2208 64 36 of of IN www-nature-com-2208 64 37 guiding guide VBG www-nature-com-2208 64 38 principles principle NNS www-nature-com-2208 64 39 for for IN www-nature-com-2208 64 40 citation citation NN www-nature-com-2208 64 41 of of IN www-nature-com-2208 64 42 data datum NNS www-nature-com-2208 64 43 within within IN www-nature-com-2208 64 44 scholarly scholarly NNP www-nature-com-2208 64 45 literature literature NNP www-nature-com-2208 64 46 , , , www-nature-com-2208 64 47 another another DT www-nature-com-2208 64 48 dataset dataset NN www-nature-com-2208 64 49 , , , www-nature-com-2208 64 50 or or CC www-nature-com-2208 64 51 any any DT www-nature-com-2208 64 52 other other JJ www-nature-com-2208 64 53 research research NN www-nature-com-2208 64 54 object object NN www-nature-com-2208 64 55 . . . www-nature-com-2208 65 1 RDF RDF NNP www-nature-com-2208 65 2 — — : www-nature-com-2208 65 3 Resource Resource NNP www-nature-com-2208 65 4 Description Description NNP www-nature-com-2208 65 5 Framework Framework NNP www-nature-com-2208 65 6 ; ; : www-nature-com-2208 65 7 a a DT www-nature-com-2208 65 8 globally globally RB www-nature-com-2208 65 9 - - HYPH www-nature-com-2208 65 10 accepted accept VBN www-nature-com-2208 65 11 framework framework NN www-nature-com-2208 65 12 for for IN www-nature-com-2208 65 13 data datum NNS www-nature-com-2208 65 14 and and CC www-nature-com-2208 65 15 knowledge knowledge NN www-nature-com-2208 65 16 representation representation NN www-nature-com-2208 65 17 that that WDT www-nature-com-2208 65 18 is be VBZ www-nature-com-2208 65 19 intended intend VBN www-nature-com-2208 65 20 to to TO www-nature-com-2208 65 21 be be VB www-nature-com-2208 65 22 read read VBN www-nature-com-2208 65 23 and and CC www-nature-com-2208 65 24 interpreted interpret VBN www-nature-com-2208 65 25 by by IN www-nature-com-2208 65 26 machines machine NNS www-nature-com-2208 65 27 . . . www-nature-com-2208 66 1 The the DT www-nature-com-2208 66 2 significance significance NN www-nature-com-2208 66 3 of of IN www-nature-com-2208 66 4 machines machine NNS www-nature-com-2208 66 5 in in IN www-nature-com-2208 66 6 data data NN www-nature-com-2208 66 7 - - HYPH www-nature-com-2208 66 8 rich rich JJ www-nature-com-2208 66 9 research research NN www-nature-com-2208 66 10 environments environment VBZ www-nature-com-2208 66 11 The the DT www-nature-com-2208 66 12 emphasis emphasis NN www-nature-com-2208 66 13 placed place VBN www-nature-com-2208 66 14 on on IN www-nature-com-2208 66 15 FAIRness fairness NN www-nature-com-2208 66 16 being be VBG www-nature-com-2208 66 17 applied apply VBN www-nature-com-2208 66 18 to to IN www-nature-com-2208 66 19 both both CC www-nature-com-2208 66 20 human human NN www-nature-com-2208 66 21 - - HYPH www-nature-com-2208 66 22 driven drive VBN www-nature-com-2208 66 23 and and CC www-nature-com-2208 66 24 machine machine NN www-nature-com-2208 66 25 - - HYPH www-nature-com-2208 66 26 driven drive VBN www-nature-com-2208 66 27 activities activity NNS www-nature-com-2208 66 28 , , , www-nature-com-2208 66 29 is be VBZ www-nature-com-2208 66 30 a a DT www-nature-com-2208 66 31 specific specific JJ www-nature-com-2208 66 32 focus focus NN www-nature-com-2208 66 33 of of IN www-nature-com-2208 66 34 the the DT www-nature-com-2208 66 35 FAIR FAIR NNP www-nature-com-2208 66 36 Guiding Guiding NNP www-nature-com-2208 66 37 Principles Principles NNPS www-nature-com-2208 66 38 that that WDT www-nature-com-2208 66 39 distinguishes distinguish VBZ www-nature-com-2208 66 40 them -PRON- PRP www-nature-com-2208 66 41 from from IN www-nature-com-2208 66 42 many many JJ www-nature-com-2208 66 43 peer peer NN www-nature-com-2208 66 44 initiatives initiative NNS www-nature-com-2208 66 45 ( ( -LRB- www-nature-com-2208 66 46 discussed discuss VBN www-nature-com-2208 66 47 in in IN www-nature-com-2208 66 48 the the DT www-nature-com-2208 66 49 subsequent subsequent JJ www-nature-com-2208 66 50 section section NN www-nature-com-2208 66 51 ) ) -RRB- www-nature-com-2208 66 52 . . . www-nature-com-2208 67 1 Humans human NNS www-nature-com-2208 67 2 and and CC www-nature-com-2208 67 3 machines machine NNS www-nature-com-2208 67 4 often often RB www-nature-com-2208 67 5 face face VBP www-nature-com-2208 67 6 distinct distinct JJ www-nature-com-2208 67 7 barriers barrier NNS www-nature-com-2208 67 8 when when WRB www-nature-com-2208 67 9 attempting attempt VBG www-nature-com-2208 67 10 to to TO www-nature-com-2208 67 11 find find VB www-nature-com-2208 67 12 and and CC www-nature-com-2208 67 13 process process VB www-nature-com-2208 67 14 data datum NNS www-nature-com-2208 67 15 on on IN www-nature-com-2208 67 16 the the DT www-nature-com-2208 67 17 Web web NN www-nature-com-2208 67 18 . . . www-nature-com-2208 68 1 Humans human NNS www-nature-com-2208 68 2 have have VBP www-nature-com-2208 68 3 an an DT www-nature-com-2208 68 4 intuitive intuitive JJ www-nature-com-2208 68 5 sense sense NN www-nature-com-2208 68 6 of of IN www-nature-com-2208 68 7 ‘ ' `` www-nature-com-2208 68 8 semantics semantic NNS www-nature-com-2208 68 9 ’ ' '' www-nature-com-2208 68 10 ( ( -LRB- www-nature-com-2208 68 11 the the DT www-nature-com-2208 68 12 meaning meaning NN www-nature-com-2208 68 13 or or CC www-nature-com-2208 68 14 intent intent NN www-nature-com-2208 68 15 of of IN www-nature-com-2208 68 16 a a DT www-nature-com-2208 68 17 digital digital JJ www-nature-com-2208 68 18 object object NN www-nature-com-2208 68 19 ) ) -RRB- www-nature-com-2208 68 20 because because IN www-nature-com-2208 68 21 we -PRON- PRP www-nature-com-2208 68 22 are be VBP www-nature-com-2208 68 23 capable capable JJ www-nature-com-2208 68 24 of of IN www-nature-com-2208 68 25 identifying identify VBG www-nature-com-2208 68 26 and and CC www-nature-com-2208 68 27 interpreting interpret VBG www-nature-com-2208 68 28 a a DT www-nature-com-2208 68 29 wide wide JJ www-nature-com-2208 68 30 variety variety NN www-nature-com-2208 68 31 of of IN www-nature-com-2208 68 32 contextual contextual JJ www-nature-com-2208 68 33 cues cue NNS www-nature-com-2208 68 34 , , , www-nature-com-2208 68 35 whether whether IN www-nature-com-2208 68 36 those those DT www-nature-com-2208 68 37 take take VBP www-nature-com-2208 68 38 the the DT www-nature-com-2208 68 39 form form NN www-nature-com-2208 68 40 of of IN www-nature-com-2208 68 41 structural structural JJ www-nature-com-2208 68 42 / / SYM www-nature-com-2208 68 43 visual visual JJ www-nature-com-2208 68 44 / / SYM www-nature-com-2208 68 45 iconic iconic JJ www-nature-com-2208 68 46 cues cue NNS www-nature-com-2208 68 47 in in IN www-nature-com-2208 68 48 the the DT www-nature-com-2208 68 49 layout layout NN www-nature-com-2208 68 50 of of IN www-nature-com-2208 68 51 a a DT www-nature-com-2208 68 52 Web web NN www-nature-com-2208 68 53 page page NN www-nature-com-2208 68 54 , , , www-nature-com-2208 68 55 or or CC www-nature-com-2208 68 56 the the DT www-nature-com-2208 68 57 content content NN www-nature-com-2208 68 58 of of IN www-nature-com-2208 68 59 narrative narrative JJ www-nature-com-2208 68 60 notes note NNS www-nature-com-2208 68 61 . . . www-nature-com-2208 69 1 As as IN www-nature-com-2208 69 2 such such JJ www-nature-com-2208 69 3 , , , www-nature-com-2208 69 4 we -PRON- PRP www-nature-com-2208 69 5 are be VBP www-nature-com-2208 69 6 less less RBR www-nature-com-2208 69 7 likely likely JJ www-nature-com-2208 69 8 to to TO www-nature-com-2208 69 9 make make VB www-nature-com-2208 69 10 errors error NNS www-nature-com-2208 69 11 in in IN www-nature-com-2208 69 12 the the DT www-nature-com-2208 69 13 selection selection NN www-nature-com-2208 69 14 of of IN www-nature-com-2208 69 15 appropriate appropriate JJ www-nature-com-2208 69 16 data datum NNS www-nature-com-2208 69 17 or or CC www-nature-com-2208 69 18 other other JJ www-nature-com-2208 69 19 digital digital JJ www-nature-com-2208 69 20 objects object NNS www-nature-com-2208 69 21 , , , www-nature-com-2208 69 22 although although IN www-nature-com-2208 69 23 humans human NNS www-nature-com-2208 69 24 will will MD www-nature-com-2208 69 25 face face VB www-nature-com-2208 69 26 similar similar JJ www-nature-com-2208 69 27 difficulties difficulty NNS www-nature-com-2208 69 28 if if IN www-nature-com-2208 69 29 sufficient sufficient JJ www-nature-com-2208 69 30 contextual contextual JJ www-nature-com-2208 69 31 metadata metadata NN www-nature-com-2208 69 32 is be VBZ www-nature-com-2208 69 33 lacking lack VBG www-nature-com-2208 69 34 . . . www-nature-com-2208 70 1 The the DT www-nature-com-2208 70 2 primary primary JJ www-nature-com-2208 70 3 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72 17 range range NN www-nature-com-2208 72 18 of of IN www-nature-com-2208 72 19 types type NNS www-nature-com-2208 72 20 , , , www-nature-com-2208 72 21 formats format NNS www-nature-com-2208 72 22 , , , www-nature-com-2208 72 23 and and CC www-nature-com-2208 72 24 access access NN www-nature-com-2208 72 25 - - HYPH www-nature-com-2208 72 26 mechanisms mechanism NNS www-nature-com-2208 72 27 / / SYM www-nature-com-2208 72 28 protocols protocol NNS www-nature-com-2208 72 29 that that WDT www-nature-com-2208 72 30 will will MD www-nature-com-2208 72 31 be be VB www-nature-com-2208 72 32 encountered encounter VBN www-nature-com-2208 72 33 during during IN www-nature-com-2208 72 34 their -PRON- PRP$ www-nature-com-2208 72 35 self self NN www-nature-com-2208 72 36 - - HYPH www-nature-com-2208 72 37 guided guide VBN www-nature-com-2208 72 38 exploration exploration NN www-nature-com-2208 72 39 of of IN www-nature-com-2208 72 40 the the DT www-nature-com-2208 72 41 global global JJ www-nature-com-2208 72 42 data datum NNS www-nature-com-2208 72 43 ecosystem ecosystem NN www-nature-com-2208 72 44 . . . www-nature-com-2208 73 1 It -PRON- PRP www-nature-com-2208 73 2 also also RB www-nature-com-2208 73 3 necessitates necessitate VBZ www-nature-com-2208 73 4 that that IN www-nature-com-2208 73 5 the the DT www-nature-com-2208 73 6 machines machine NNS www-nature-com-2208 73 7 keep keep VBP www-nature-com-2208 73 8 an an DT www-nature-com-2208 73 9 exquisite exquisite JJ www-nature-com-2208 73 10 record record NN www-nature-com-2208 73 11 of of IN www-nature-com-2208 73 12 provenance provenance NN www-nature-com-2208 73 13 such such JJ www-nature-com-2208 73 14 that that IN www-nature-com-2208 73 15 the the DT www-nature-com-2208 73 16 data datum NNS www-nature-com-2208 73 17 they -PRON- PRP www-nature-com-2208 73 18 are be VBP www-nature-com-2208 73 19 collecting collect VBG www-nature-com-2208 73 20 can can MD www-nature-com-2208 73 21 be be VB www-nature-com-2208 73 22 accurately accurately RB www-nature-com-2208 73 23 and and CC www-nature-com-2208 73 24 adequately adequately RB www-nature-com-2208 73 25 cited cite VBN www-nature-com-2208 73 26 . . . www-nature-com-2208 74 1 Assisting assist VBG www-nature-com-2208 74 2 these these DT www-nature-com-2208 74 3 agents agent NNS www-nature-com-2208 74 4 , , , www-nature-com-2208 74 5 therefore therefore RB www-nature-com-2208 74 6 , , , www-nature-com-2208 74 7 is be VBZ www-nature-com-2208 74 8 a a DT www-nature-com-2208 74 9 critical critical JJ www-nature-com-2208 74 10 consideration consideration NN www-nature-com-2208 74 11 for for IN www-nature-com-2208 74 12 all all DT www-nature-com-2208 74 13 participants participant NNS www-nature-com-2208 74 14 in in IN www-nature-com-2208 74 15 the the DT www-nature-com-2208 74 16 data data NN www-nature-com-2208 74 17 management management NN www-nature-com-2208 74 18 and and CC www-nature-com-2208 74 19 stewardship stewardship NN www-nature-com-2208 74 20 process process NN www-nature-com-2208 74 21 — — : www-nature-com-2208 74 22 from from IN www-nature-com-2208 74 23 researchers researcher NNS www-nature-com-2208 74 24 and and CC www-nature-com-2208 74 25 data datum NNS www-nature-com-2208 74 26 producers producer NNS www-nature-com-2208 74 27 to to IN www-nature-com-2208 74 28 data datum NNS www-nature-com-2208 74 29 repository repository JJ www-nature-com-2208 74 30 hosts host NNS www-nature-com-2208 74 31 . . . www-nature-com-2208 75 1 Throughout throughout IN www-nature-com-2208 75 2 this this DT www-nature-com-2208 75 3 paper paper NN www-nature-com-2208 75 4 , , , www-nature-com-2208 75 5 we -PRON- PRP www-nature-com-2208 75 6 use use VBP www-nature-com-2208 75 7 the the DT www-nature-com-2208 75 8 phrase phrase NN www-nature-com-2208 75 9 ‘ ' `` www-nature-com-2208 75 10 machine machine NN www-nature-com-2208 75 11 actionable actionable RB www-nature-com-2208 75 12 ’ ' '' www-nature-com-2208 75 13 to to TO www-nature-com-2208 75 14 indicate indicate VB www-nature-com-2208 75 15 a a DT www-nature-com-2208 75 16 continuum continuum NN www-nature-com-2208 75 17 of of IN www-nature-com-2208 75 18 possible possible JJ www-nature-com-2208 75 19 states state NNS www-nature-com-2208 75 20 wherein wherein WRB www-nature-com-2208 75 21 a a DT www-nature-com-2208 75 22 digital digital JJ www-nature-com-2208 75 23 object object NN www-nature-com-2208 75 24 provides provide VBZ www-nature-com-2208 75 25 increasingly increasingly RB www-nature-com-2208 75 26 more more RBR www-nature-com-2208 75 27 detailed detailed JJ www-nature-com-2208 75 28 information information NN www-nature-com-2208 75 29 to to IN www-nature-com-2208 75 30 an an DT www-nature-com-2208 75 31 autonomously autonomously RB www-nature-com-2208 75 32 - - HYPH www-nature-com-2208 75 33 acting act VBG www-nature-com-2208 75 34 , , , www-nature-com-2208 75 35 computational computational JJ www-nature-com-2208 75 36 data datum NNS www-nature-com-2208 75 37 explorer explorer NN www-nature-com-2208 75 38 . . . www-nature-com-2208 76 1 This this DT www-nature-com-2208 76 2 information information NN www-nature-com-2208 76 3 enables enable VBZ www-nature-com-2208 76 4 the the DT www-nature-com-2208 76 5 agent agent NN www-nature-com-2208 76 6 — — : www-nature-com-2208 76 7 to to IN www-nature-com-2208 76 8 a a DT www-nature-com-2208 76 9 degree degree NN www-nature-com-2208 76 10 dependent dependent JJ www-nature-com-2208 76 11 on on IN www-nature-com-2208 76 12 the the DT www-nature-com-2208 76 13 amount amount NN www-nature-com-2208 76 14 of of IN www-nature-com-2208 76 15 detail detail NN www-nature-com-2208 76 16 provided provide VBN www-nature-com-2208 76 17 — — : www-nature-com-2208 76 18 to to TO www-nature-com-2208 76 19 have have VB www-nature-com-2208 76 20 the the DT www-nature-com-2208 76 21 capacity capacity NN www-nature-com-2208 76 22 , , , www-nature-com-2208 76 23 when when WRB www-nature-com-2208 76 24 faced face VBN www-nature-com-2208 76 25 with with IN www-nature-com-2208 76 26 a a DT www-nature-com-2208 76 27 digital digital JJ www-nature-com-2208 76 28 object object NN www-nature-com-2208 76 29 never never RB www-nature-com-2208 76 30 encountered encounter VBN www-nature-com-2208 76 31 before before RB www-nature-com-2208 76 32 , , , www-nature-com-2208 76 33 to to IN www-nature-com-2208 76 34 : : : www-nature-com-2208 76 35 a a LS www-nature-com-2208 76 36 ) ) -RRB- www-nature-com-2208 76 37 identify identify VB www-nature-com-2208 76 38 the the DT www-nature-com-2208 76 39 type type NN www-nature-com-2208 76 40 of of IN www-nature-com-2208 76 41 object object NN www-nature-com-2208 76 42 ( ( -LRB- www-nature-com-2208 76 43 with with IN www-nature-com-2208 76 44 respect respect NN www-nature-com-2208 76 45 to to IN www-nature-com-2208 76 46 both both CC www-nature-com-2208 76 47 structure structure NN www-nature-com-2208 76 48 and and CC www-nature-com-2208 76 49 intent intent NN www-nature-com-2208 76 50 ) ) -RRB- www-nature-com-2208 76 51 , , , www-nature-com-2208 76 52 b b LS www-nature-com-2208 76 53 ) ) -RRB- www-nature-com-2208 76 54 determine determine VB www-nature-com-2208 76 55 if if IN www-nature-com-2208 76 56 it -PRON- PRP www-nature-com-2208 76 57 is be VBZ www-nature-com-2208 76 58 useful useful JJ www-nature-com-2208 76 59 within within IN www-nature-com-2208 76 60 the the DT www-nature-com-2208 76 61 context context NN www-nature-com-2208 76 62 of of IN www-nature-com-2208 76 63 the the DT www-nature-com-2208 76 64 agent agent NN www-nature-com-2208 76 65 ’s ’s POS www-nature-com-2208 76 66 current current JJ www-nature-com-2208 76 67 task task NN www-nature-com-2208 76 68 by by IN www-nature-com-2208 76 69 interrogating interrogate VBG www-nature-com-2208 76 70 metadata metadata NN www-nature-com-2208 76 71 and/or and/or CC www-nature-com-2208 76 72 data data NN www-nature-com-2208 76 73 elements element NNS www-nature-com-2208 76 74 , , , www-nature-com-2208 76 75 c c LS www-nature-com-2208 76 76 ) ) -RRB- www-nature-com-2208 76 77 determine determine VBP www-nature-com-2208 76 78 if if IN www-nature-com-2208 76 79 it -PRON- PRP www-nature-com-2208 76 80 is be VBZ www-nature-com-2208 76 81 usable usable JJ www-nature-com-2208 76 82 , , , www-nature-com-2208 76 83 with with IN www-nature-com-2208 76 84 respect respect NN www-nature-com-2208 76 85 to to IN www-nature-com-2208 76 86 license license NN www-nature-com-2208 76 87 , , , www-nature-com-2208 76 88 consent consent NN www-nature-com-2208 76 89 , , , www-nature-com-2208 76 90 or or CC www-nature-com-2208 76 91 other other JJ www-nature-com-2208 76 92 accessibility accessibility NN www-nature-com-2208 76 93 or or CC www-nature-com-2208 76 94 use use VB www-nature-com-2208 76 95 constraints constraint NNS www-nature-com-2208 76 96 , , , www-nature-com-2208 76 97 and and CC www-nature-com-2208 76 98 d d LS www-nature-com-2208 76 99 ) ) -RRB- www-nature-com-2208 76 100 take take VB www-nature-com-2208 76 101 appropriate appropriate JJ www-nature-com-2208 76 102 action action NN www-nature-com-2208 76 103 , , , www-nature-com-2208 76 104 in in IN www-nature-com-2208 76 105 much much RB www-nature-com-2208 76 106 the the DT www-nature-com-2208 76 107 same same JJ www-nature-com-2208 76 108 manner manner NN www-nature-com-2208 76 109 that that WDT www-nature-com-2208 76 110 a a DT www-nature-com-2208 76 111 human human NN www-nature-com-2208 76 112 would would NN www-nature-com-2208 76 113 . . . www-nature-com-2208 77 1 For for IN www-nature-com-2208 77 2 example example NN www-nature-com-2208 77 3 , , , www-nature-com-2208 77 4 a a DT www-nature-com-2208 77 5 machine machine NN www-nature-com-2208 77 6 may may MD www-nature-com-2208 77 7 be be VB www-nature-com-2208 77 8 capable capable JJ www-nature-com-2208 77 9 of of IN www-nature-com-2208 77 10 determining determine VBG www-nature-com-2208 77 11 the the DT www-nature-com-2208 77 12 data data NN www-nature-com-2208 77 13 - - HYPH www-nature-com-2208 77 14 type type NN www-nature-com-2208 77 15 of of IN www-nature-com-2208 77 16 a a DT www-nature-com-2208 77 17 discovered discover VBN www-nature-com-2208 77 18 digital digital JJ www-nature-com-2208 77 19 object object NN www-nature-com-2208 77 20 , , , www-nature-com-2208 77 21 but but CC www-nature-com-2208 77 22 not not RB www-nature-com-2208 77 23 capable capable JJ www-nature-com-2208 77 24 of of IN www-nature-com-2208 77 25 parsing parse VBG www-nature-com-2208 77 26 it -PRON- PRP www-nature-com-2208 77 27 due due IN www-nature-com-2208 77 28 to to IN www-nature-com-2208 77 29 it -PRON- PRP www-nature-com-2208 77 30 being be VBG www-nature-com-2208 77 31 in in IN www-nature-com-2208 77 32 an an DT www-nature-com-2208 77 33 unknown unknown JJ www-nature-com-2208 77 34 format format NN www-nature-com-2208 77 35 ; ; : www-nature-com-2208 77 36 or or CC www-nature-com-2208 77 37 it -PRON- PRP www-nature-com-2208 77 38 may may MD www-nature-com-2208 77 39 be be VB www-nature-com-2208 77 40 capable capable JJ www-nature-com-2208 77 41 of of IN www-nature-com-2208 77 42 processing process VBG www-nature-com-2208 77 43 the the DT www-nature-com-2208 77 44 contained contain VBN www-nature-com-2208 77 45 data datum NNS www-nature-com-2208 77 46 , , , www-nature-com-2208 77 47 but but CC www-nature-com-2208 77 48 not not RB www-nature-com-2208 77 49 capable capable JJ www-nature-com-2208 77 50 of of IN www-nature-com-2208 77 51 determining determine VBG www-nature-com-2208 77 52 the the DT www-nature-com-2208 77 53 licensing licensing NN www-nature-com-2208 77 54 requirements requirement NNS www-nature-com-2208 77 55 related relate VBN www-nature-com-2208 77 56 to to IN www-nature-com-2208 77 57 the the DT www-nature-com-2208 77 58 retrieval retrieval NN www-nature-com-2208 77 59 and/or and/or CC www-nature-com-2208 77 60 use use NN www-nature-com-2208 77 61 of of IN www-nature-com-2208 77 62 that that DT www-nature-com-2208 77 63 data datum NNS www-nature-com-2208 77 64 . . . www-nature-com-2208 78 1 The the DT www-nature-com-2208 78 2 optimal optimal JJ www-nature-com-2208 78 3 state state NN www-nature-com-2208 78 4 — — : www-nature-com-2208 78 5 where where WRB www-nature-com-2208 78 6 machines machine NNS www-nature-com-2208 78 7 fully fully RB www-nature-com-2208 78 8 ‘ ' `` www-nature-com-2208 78 9 understand understand VB www-nature-com-2208 78 10 ’ ' '' www-nature-com-2208 78 11 and and CC www-nature-com-2208 78 12 can can MD www-nature-com-2208 78 13 autonomously autonomously RB www-nature-com-2208 78 14 and and CC www-nature-com-2208 78 15 correctly correctly RB www-nature-com-2208 78 16 operate operate VB www-nature-com-2208 78 17 - - : www-nature-com-2208 78 18 on on IN www-nature-com-2208 78 19 a a DT www-nature-com-2208 78 20 digital digital JJ www-nature-com-2208 78 21 object object NN www-nature-com-2208 78 22 — — : www-nature-com-2208 78 23 may may MD www-nature-com-2208 78 24 rarely rarely RB www-nature-com-2208 78 25 be be VB www-nature-com-2208 78 26 achieved achieve VBN www-nature-com-2208 78 27 . . . www-nature-com-2208 79 1 Nevertheless nevertheless RB www-nature-com-2208 79 2 , , , www-nature-com-2208 79 3 the the DT www-nature-com-2208 79 4 FAIR FAIR NNP www-nature-com-2208 79 5 principles principle NNS www-nature-com-2208 79 6 provide provide VBP www-nature-com-2208 79 7 ‘ ' `` www-nature-com-2208 79 8 steps step NNS www-nature-com-2208 79 9 along along IN www-nature-com-2208 79 10 a a DT www-nature-com-2208 79 11 path path NN www-nature-com-2208 79 12 ’ ' '' www-nature-com-2208 79 13 toward toward IN www-nature-com-2208 79 14 machine machine NN www-nature-com-2208 79 15 - - HYPH www-nature-com-2208 79 16 actionability actionability NN www-nature-com-2208 79 17 ; ; : www-nature-com-2208 79 18 adopting adopt VBG www-nature-com-2208 79 19 , , , www-nature-com-2208 79 20 in in IN www-nature-com-2208 79 21 whole whole NN www-nature-com-2208 79 22 or or CC www-nature-com-2208 79 23 in in IN www-nature-com-2208 79 24 part part NN www-nature-com-2208 79 25 , , , www-nature-com-2208 79 26 the the DT www-nature-com-2208 79 27 FAIR FAIR NNP www-nature-com-2208 79 28 principles principle NNS www-nature-com-2208 79 29 , , , www-nature-com-2208 79 30 leads lead VBZ www-nature-com-2208 79 31 the the DT www-nature-com-2208 79 32 resource resource NN www-nature-com-2208 79 33 along along IN www-nature-com-2208 79 34 the the DT www-nature-com-2208 79 35 continuum continuum NN www-nature-com-2208 79 36 towards towards IN www-nature-com-2208 79 37 this this DT www-nature-com-2208 79 38 optimal optimal JJ www-nature-com-2208 79 39 state state NN www-nature-com-2208 79 40 . . . www-nature-com-2208 80 1 In in IN www-nature-com-2208 80 2 addition addition NN www-nature-com-2208 80 3 , , , www-nature-com-2208 80 4 the the DT www-nature-com-2208 80 5 idea idea NN www-nature-com-2208 80 6 of of IN www-nature-com-2208 80 7 being be VBG www-nature-com-2208 80 8 machine machine NN www-nature-com-2208 80 9 - - HYPH www-nature-com-2208 80 10 actionable actionable JJ www-nature-com-2208 80 11 applies applie NNS www-nature-com-2208 80 12 in in IN www-nature-com-2208 80 13 two two CD www-nature-com-2208 80 14 contexts contexts NN www-nature-com-2208 80 15 — — : www-nature-com-2208 80 16 first first RB www-nature-com-2208 80 17 , , , www-nature-com-2208 80 18 when when WRB www-nature-com-2208 80 19 referring refer VBG www-nature-com-2208 80 20 to to IN www-nature-com-2208 80 21 the the DT www-nature-com-2208 80 22 contextual contextual JJ www-nature-com-2208 80 23 metadata metadata NN www-nature-com-2208 80 24 surrounding surround VBG www-nature-com-2208 80 25 a a DT www-nature-com-2208 80 26 digital digital JJ www-nature-com-2208 80 27 object object NN www-nature-com-2208 80 28 ( ( -LRB- www-nature-com-2208 80 29 ‘ ' `` www-nature-com-2208 80 30 what what WP www-nature-com-2208 80 31 is be VBZ www-nature-com-2208 80 32 it -PRON- PRP www-nature-com-2208 80 33 ? ? . www-nature-com-2208 80 34 ’ ' '' www-nature-com-2208 80 35 ) ) -RRB- www-nature-com-2208 80 36 , , , www-nature-com-2208 80 37 and and CC www-nature-com-2208 80 38 second second RB www-nature-com-2208 80 39 , , , www-nature-com-2208 80 40 when when WRB www-nature-com-2208 80 41 referring refer VBG www-nature-com-2208 80 42 to to IN www-nature-com-2208 80 43 the the DT www-nature-com-2208 80 44 content content NN www-nature-com-2208 80 45 of of IN www-nature-com-2208 80 46 the the DT www-nature-com-2208 80 47 digital digital JJ www-nature-com-2208 80 48 object object NN www-nature-com-2208 80 49 itself -PRON- PRP www-nature-com-2208 80 50 ( ( -LRB- www-nature-com-2208 80 51 ‘ ' `` www-nature-com-2208 80 52 how how WRB www-nature-com-2208 80 53 do do VBP www-nature-com-2208 80 54 I -PRON- PRP www-nature-com-2208 80 55 process process VB www-nature-com-2208 80 56 it -PRON- PRP www-nature-com-2208 80 57 / / SYM www-nature-com-2208 80 58 integrate integrate VB www-nature-com-2208 80 59 it -PRON- PRP www-nature-com-2208 80 60 ? ? . www-nature-com-2208 80 61 ’ ' '' www-nature-com-2208 80 62 ) ) -RRB- www-nature-com-2208 80 63 . . . www-nature-com-2208 81 1 Either either RB www-nature-com-2208 81 2 , , , www-nature-com-2208 81 3 or or CC www-nature-com-2208 81 4 both both DT www-nature-com-2208 81 5 of of IN www-nature-com-2208 81 6 these these DT www-nature-com-2208 81 7 may may MD www-nature-com-2208 81 8 be be VB www-nature-com-2208 81 9 machine machine NN www-nature-com-2208 81 10 - - HYPH www-nature-com-2208 81 11 actionable actionable JJ www-nature-com-2208 81 12 , , , www-nature-com-2208 81 13 and and CC www-nature-com-2208 81 14 each each DT www-nature-com-2208 81 15 forms form NNS www-nature-com-2208 81 16 its -PRON- PRP$ www-nature-com-2208 81 17 own own JJ www-nature-com-2208 81 18 continuum continuum NN www-nature-com-2208 81 19 of of IN www-nature-com-2208 81 20 actionability actionability NN www-nature-com-2208 81 21 . . . www-nature-com-2208 82 1 Finally finally RB www-nature-com-2208 82 2 , , , www-nature-com-2208 82 3 we -PRON- PRP www-nature-com-2208 82 4 wish wish VBP www-nature-com-2208 82 5 to to TO www-nature-com-2208 82 6 draw draw VB www-nature-com-2208 82 7 a a DT www-nature-com-2208 82 8 distinction distinction NN www-nature-com-2208 82 9 between between IN www-nature-com-2208 82 10 data datum NNS www-nature-com-2208 82 11 that that WDT www-nature-com-2208 82 12 is be VBZ www-nature-com-2208 82 13 machine machine NN www-nature-com-2208 82 14 - - HYPH www-nature-com-2208 82 15 actionable actionable JJ www-nature-com-2208 82 16 as as IN www-nature-com-2208 82 17 a a DT www-nature-com-2208 82 18 result result NN www-nature-com-2208 82 19 of of IN www-nature-com-2208 82 20 specific specific JJ www-nature-com-2208 82 21 investment investment NN www-nature-com-2208 82 22 in in IN www-nature-com-2208 82 23 software software NN www-nature-com-2208 82 24 supporting support VBG www-nature-com-2208 82 25 that that IN www-nature-com-2208 82 26 data data NN www-nature-com-2208 82 27 - - HYPH www-nature-com-2208 82 28 type type NN www-nature-com-2208 82 29 , , , www-nature-com-2208 82 30 for for IN www-nature-com-2208 82 31 example example NN www-nature-com-2208 82 32 , , , www-nature-com-2208 82 33 bespoke bespoke NN www-nature-com-2208 82 34 parsers parser NNS www-nature-com-2208 82 35 that that WDT www-nature-com-2208 82 36 understand understand VBP www-nature-com-2208 82 37 life life NN www-nature-com-2208 82 38 science science NN www-nature-com-2208 82 39 wwPDB wwpdb JJ www-nature-com-2208 82 40 files file NNS www-nature-com-2208 82 41 or or CC www-nature-com-2208 82 42 space space NN www-nature-com-2208 82 43 science science NN www-nature-com-2208 82 44 Space Space NNP www-nature-com-2208 82 45 Physics Physics NNP www-nature-com-2208 82 46 Archive Archive NNP www-nature-com-2208 82 47 Search Search NNP www-nature-com-2208 82 48 and and CC www-nature-com-2208 82 49 Extract Extract NNP www-nature-com-2208 82 50 ( ( -LRB- www-nature-com-2208 82 51 SPASE SPASE NNP www-nature-com-2208 82 52 ) ) -RRB- www-nature-com-2208 82 53 files file NNS www-nature-com-2208 82 54 , , , www-nature-com-2208 82 55 and and CC www-nature-com-2208 82 56 data datum NNS www-nature-com-2208 82 57 that that WDT www-nature-com-2208 82 58 is be VBZ www-nature-com-2208 82 59 machine machine NN www-nature-com-2208 82 60 - - HYPH www-nature-com-2208 82 61 actionable actionable RB www-nature-com-2208 82 62 exclusively exclusively RB www-nature-com-2208 82 63 through through IN www-nature-com-2208 82 64 the the DT www-nature-com-2208 82 65 utilization utilization NN www-nature-com-2208 82 66 of of IN www-nature-com-2208 82 67 general general JJ www-nature-com-2208 82 68 - - HYPH www-nature-com-2208 82 69 purpose purpose NN www-nature-com-2208 82 70 , , , www-nature-com-2208 82 71 open open JJ www-nature-com-2208 82 72 technologies technology NNS www-nature-com-2208 82 73 . . . www-nature-com-2208 83 1 To to TO www-nature-com-2208 83 2 reiterate reiterate VB www-nature-com-2208 83 3 the the DT www-nature-com-2208 83 4 earlier early JJR www-nature-com-2208 83 5 point point NN www-nature-com-2208 83 6 — — : www-nature-com-2208 83 7 ultimate ultimate JJ www-nature-com-2208 83 8 machine machine NN www-nature-com-2208 83 9 - - HYPH www-nature-com-2208 83 10 actionability actionability NN www-nature-com-2208 83 11 occurs occur VBZ www-nature-com-2208 83 12 when when WRB www-nature-com-2208 83 13 a a DT www-nature-com-2208 83 14 machine machine NN www-nature-com-2208 83 15 can can MD www-nature-com-2208 83 16 make make VB www-nature-com-2208 83 17 a a DT www-nature-com-2208 83 18 useful useful JJ www-nature-com-2208 83 19 decision decision NN www-nature-com-2208 83 20 regarding regard VBG www-nature-com-2208 83 21 data datum NNS www-nature-com-2208 83 22 that that IN www-nature-com-2208 83 23 it -PRON- PRP www-nature-com-2208 83 24 has have VBZ www-nature-com-2208 83 25 not not RB www-nature-com-2208 83 26 encountered encounter VBN www-nature-com-2208 83 27 before before RB www-nature-com-2208 83 28 . . . www-nature-com-2208 84 1 This this DT www-nature-com-2208 84 2 distinction distinction NN www-nature-com-2208 84 3 is be VBZ www-nature-com-2208 84 4 important important JJ www-nature-com-2208 84 5 when when WRB www-nature-com-2208 84 6 considering consider VBG www-nature-com-2208 84 7 both both DT www-nature-com-2208 84 8 ( ( -LRB- www-nature-com-2208 84 9 a a LS www-nature-com-2208 84 10 ) ) -RRB- www-nature-com-2208 84 11 the the DT www-nature-com-2208 84 12 rapidly rapidly RB www-nature-com-2208 84 13 growing grow VBG www-nature-com-2208 84 14 and and CC www-nature-com-2208 84 15 evolving evolve VBG www-nature-com-2208 84 16 data data NN www-nature-com-2208 84 17 environment environment NN www-nature-com-2208 84 18 , , , www-nature-com-2208 84 19 with with IN www-nature-com-2208 84 20 new new JJ www-nature-com-2208 84 21 technologies technology NNS www-nature-com-2208 84 22 and and CC www-nature-com-2208 84 23 new new JJ www-nature-com-2208 84 24 , , , www-nature-com-2208 84 25 more more RBR www-nature-com-2208 84 26 complex complex JJ www-nature-com-2208 84 27 data datum NNS www-nature-com-2208 84 28 - - HYPH www-nature-com-2208 84 29 types type NNS www-nature-com-2208 84 30 continuously continuously RB www-nature-com-2208 84 31 being be VBG www-nature-com-2208 84 32 developed develop VBN www-nature-com-2208 84 33 , , , www-nature-com-2208 84 34 and and CC www-nature-com-2208 84 35 ( ( -LRB- www-nature-com-2208 84 36 b b LS www-nature-com-2208 84 37 ) ) -RRB- www-nature-com-2208 84 38 the the DT www-nature-com-2208 84 39 growth growth NN www-nature-com-2208 84 40 of of IN www-nature-com-2208 84 41 general general JJ www-nature-com-2208 84 42 - - HYPH www-nature-com-2208 84 43 purpose purpose NN www-nature-com-2208 84 44 repositories repository NNS www-nature-com-2208 84 45 , , , www-nature-com-2208 84 46 where where WRB www-nature-com-2208 84 47 the the DT www-nature-com-2208 84 48 data data NN www-nature-com-2208 84 49 - - HYPH www-nature-com-2208 84 50 types type NNS www-nature-com-2208 84 51 likely likely JJ www-nature-com-2208 84 52 to to TO www-nature-com-2208 84 53 be be VB www-nature-com-2208 84 54 encountered encounter VBN www-nature-com-2208 84 55 by by IN www-nature-com-2208 84 56 an an DT www-nature-com-2208 84 57 agent agent NN www-nature-com-2208 84 58 are be VBP www-nature-com-2208 84 59 unpredictable unpredictable JJ www-nature-com-2208 84 60 . . . www-nature-com-2208 85 1 Creating create VBG www-nature-com-2208 85 2 bespoke bespoke NN www-nature-com-2208 85 3 parsers parser NNS www-nature-com-2208 85 4 , , , www-nature-com-2208 85 5 in in IN www-nature-com-2208 85 6 all all DT www-nature-com-2208 85 7 computer computer NN www-nature-com-2208 85 8 languages language NNS www-nature-com-2208 85 9 , , , www-nature-com-2208 85 10 for for IN www-nature-com-2208 85 11 all all DT www-nature-com-2208 85 12 data datum NNS www-nature-com-2208 85 13 - - HYPH www-nature-com-2208 85 14 types type NNS www-nature-com-2208 85 15 and and CC www-nature-com-2208 85 16 all all DT www-nature-com-2208 85 17 analytical analytical JJ www-nature-com-2208 85 18 tools tool NNS www-nature-com-2208 85 19 that that WDT www-nature-com-2208 85 20 require require VBP www-nature-com-2208 85 21 those those DT www-nature-com-2208 85 22 data datum NNS www-nature-com-2208 85 23 - - HYPH www-nature-com-2208 85 24 types type NNS www-nature-com-2208 85 25 , , , www-nature-com-2208 85 26 is be VBZ www-nature-com-2208 85 27 not not RB www-nature-com-2208 85 28 a a DT www-nature-com-2208 85 29 sustainable sustainable JJ www-nature-com-2208 85 30 activity activity NN www-nature-com-2208 85 31 . . . www-nature-com-2208 86 1 As as IN www-nature-com-2208 86 2 such such JJ www-nature-com-2208 86 3 , , , www-nature-com-2208 86 4 the the DT www-nature-com-2208 86 5 focus focus NN www-nature-com-2208 86 6 on on IN www-nature-com-2208 86 7 assisting assist VBG www-nature-com-2208 86 8 machines machine NNS www-nature-com-2208 86 9 in in IN www-nature-com-2208 86 10 their -PRON- PRP$ www-nature-com-2208 86 11 discovery discovery NN www-nature-com-2208 86 12 and and CC www-nature-com-2208 86 13 exploration exploration NN www-nature-com-2208 86 14 of of IN www-nature-com-2208 86 15 data datum NNS www-nature-com-2208 86 16 through through IN www-nature-com-2208 86 17 application application NN www-nature-com-2208 86 18 of of IN www-nature-com-2208 86 19 more more RBR www-nature-com-2208 86 20 generalized generalize VBN www-nature-com-2208 86 21 interoperability interoperability NN www-nature-com-2208 86 22 technologies technology NNS www-nature-com-2208 86 23 and and CC www-nature-com-2208 86 24 standards standard NNS www-nature-com-2208 86 25 at at IN www-nature-com-2208 86 26 the the DT www-nature-com-2208 86 27 data datum NNS www-nature-com-2208 86 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WDT www-nature-com-2208 87 36 have have VBP www-nature-com-2208 87 37 been be VBN www-nature-com-2208 87 38 refined refine VBN www-nature-com-2208 87 39 ( ( -LRB- www-nature-com-2208 87 40 Box Box NNP www-nature-com-2208 87 41 2 2 CD www-nature-com-2208 87 42 ) ) -RRB- www-nature-com-2208 87 43 from from IN www-nature-com-2208 87 44 the the DT www-nature-com-2208 87 45 meeting meeting NN www-nature-com-2208 87 46 ’s ’s POS www-nature-com-2208 87 47 original original JJ www-nature-com-2208 87 48 draft draft NN www-nature-com-2208 87 49 , , , www-nature-com-2208 87 50 available available JJ www-nature-com-2208 87 51 at at IN www-nature-com-2208 87 52 ( ( -LRB- www-nature-com-2208 87 53 https://www.force11.org/node/6062 https://www.force11.org/node/6062 NNP www-nature-com-2208 87 54 ) ) -RRB- www-nature-com-2208 87 55 . . . www-nature-com-2208 88 1 A a DT www-nature-com-2208 88 2 separate separate JJ www-nature-com-2208 88 3 document document NN www-nature-com-2208 88 4 that that WDT 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, , , www-nature-com-2208 88 28 is be VBZ www-nature-com-2208 88 29 currently currently RB www-nature-com-2208 88 30 being be VBG www-nature-com-2208 88 31 constructed construct VBN www-nature-com-2208 88 32 ( ( -LRB- www-nature-com-2208 88 33 http://datafairport.org/fair-principles-living-document-menu http://datafairport.org/fair-principles-living-document-menu NNP www-nature-com-2208 88 34 ) ) -RRB- www-nature-com-2208 88 35 . . . www-nature-com-2208 89 1 The the DT www-nature-com-2208 89 2 FAIR FAIR NNP www-nature-com-2208 89 3 Guiding Guiding NNP www-nature-com-2208 89 4 Principles Principles NNPS www-nature-com-2208 89 5 describe describe VBP www-nature-com-2208 89 6 distinct distinct JJ www-nature-com-2208 89 7 considerations consideration NNS www-nature-com-2208 89 8 for for IN www-nature-com-2208 89 9 contemporary contemporary JJ www-nature-com-2208 89 10 data datum NNS www-nature-com-2208 89 11 publishing publish VBG www-nature-com-2208 89 12 environments environment NNS 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www-nature-com-2208 103 59 FAIR FAIR NNP www-nature-com-2208 103 60 principles principle NNS www-nature-com-2208 103 61 ( ( -LRB- www-nature-com-2208 103 62 ‘ ' `` www-nature-com-2208 103 63 I2 I2 NNP www-nature-com-2208 103 64 ’ ' '' www-nature-com-2208 103 65 ) ) -RRB- www-nature-com-2208 103 66 . . . www-nature-com-2208 104 1 Second second RB www-nature-com-2208 104 2 , , , www-nature-com-2208 104 3 to to TO www-nature-com-2208 104 4 explicitly explicitly RB www-nature-com-2208 104 5 identify identify VB www-nature-com-2208 104 6 the the DT www-nature-com-2208 104 7 standard standard NN www-nature-com-2208 104 8 chosen choose VBN www-nature-com-2208 104 9 when when WRB www-nature-com-2208 104 10 more more JJR www-nature-com-2208 104 11 than than IN www-nature-com-2208 104 12 one one CD www-nature-com-2208 104 13 vocabulary vocabulary NN www-nature-com-2208 104 14 or or CC www-nature-com-2208 104 15 other other JJ www-nature-com-2208 104 16 ( ( -LRB- www-nature-com-2208 104 17 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www-nature-com-2208 104 41 ( ( -LRB- www-nature-com-2208 104 42 https://biosharing.org/ https://biosharing.org/ NNP www-nature-com-2208 104 43 ) ) -RRB- www-nature-com-2208 104 44 can can MD www-nature-com-2208 104 45 be be VB www-nature-com-2208 104 46 of of IN www-nature-com-2208 104 47 use use NN www-nature-com-2208 104 48 as as IN www-nature-com-2208 104 49 it -PRON- PRP www-nature-com-2208 104 50 describes describe VBZ www-nature-com-2208 104 51 the the DT www-nature-com-2208 104 52 standards standard NNS www-nature-com-2208 104 53 in in IN www-nature-com-2208 104 54 detail detail NN www-nature-com-2208 104 55 , , , www-nature-com-2208 104 56 including include VBG www-nature-com-2208 104 57 versions version NNS www-nature-com-2208 104 58 where where WRB www-nature-com-2208 104 59 applicable applicable JJ www-nature-com-2208 104 60 . . . www-nature-com-2208 105 1 Box Box NNP www-nature-com-2208 105 2 2 2 CD www-nature-com-2208 105 3 : : : www-nature-com-2208 105 4 The the DT www-nature-com-2208 105 5 FAIR FAIR NNP www-nature-com-2208 105 6 Guiding guide VBG www-nature-com-2208 105 7 Principles Principles NNPS www-nature-com-2208 105 8 To to TO www-nature-com-2208 105 9 be be VB www-nature-com-2208 105 10 Findable findable JJ www-nature-com-2208 105 11 : : : www-nature-com-2208 105 12 F1 f1 NN www-nature-com-2208 105 13 . . . www-nature-com-2208 106 1 ( ( -LRB- www-nature-com-2208 106 2 meta)data meta)data NNP www-nature-com-2208 106 3 are be VBP www-nature-com-2208 106 4 assigned assign VBN www-nature-com-2208 106 5 a a DT www-nature-com-2208 106 6 globally globally RB www-nature-com-2208 106 7 unique unique JJ www-nature-com-2208 106 8 and and CC www-nature-com-2208 106 9 persistent persistent JJ www-nature-com-2208 106 10 identifier identifier NNP www-nature-com-2208 106 11 F2 f2 NN www-nature-com-2208 106 12 . . . www-nature-com-2208 107 1 data datum NNS www-nature-com-2208 107 2 are be VBP www-nature-com-2208 107 3 described describe VBN www-nature-com-2208 107 4 with with IN www-nature-com-2208 107 5 rich rich JJ www-nature-com-2208 107 6 metadata metadata NN www-nature-com-2208 107 7 ( ( -LRB- www-nature-com-2208 107 8 defined define VBN www-nature-com-2208 107 9 by by IN www-nature-com-2208 107 10 R1 R1 NNP www-nature-com-2208 107 11 below below RB www-nature-com-2208 107 12 ) ) -RRB- www-nature-com-2208 107 13 F3 f3 NN www-nature-com-2208 107 14 . . . www-nature-com-2208 108 1 metadata metadata NNP www-nature-com-2208 108 2 clearly clearly RB www-nature-com-2208 108 3 and and CC www-nature-com-2208 108 4 explicitly explicitly RB www-nature-com-2208 108 5 include include VB www-nature-com-2208 108 6 the the DT www-nature-com-2208 108 7 identifier identifier NN www-nature-com-2208 108 8 of of IN www-nature-com-2208 108 9 the the DT www-nature-com-2208 108 10 data datum NNS www-nature-com-2208 108 11 it -PRON- PRP www-nature-com-2208 108 12 describes describe VBZ www-nature-com-2208 108 13 F4 F4 NNP 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www-nature-com-2208 110 31 and and CC www-nature-com-2208 110 32 authorization authorization NN www-nature-com-2208 110 33 procedure procedure NN www-nature-com-2208 110 34 , , , www-nature-com-2208 110 35 where where WRB www-nature-com-2208 110 36 necessary necessary JJ www-nature-com-2208 110 37 A2 a2 NN www-nature-com-2208 110 38 . . . www-nature-com-2208 111 1 metadata metadata NN www-nature-com-2208 111 2 are be VBP www-nature-com-2208 111 3 accessible accessible JJ www-nature-com-2208 111 4 , , , www-nature-com-2208 111 5 even even RB www-nature-com-2208 111 6 when when WRB www-nature-com-2208 111 7 the the DT www-nature-com-2208 111 8 data datum NNS www-nature-com-2208 111 9 are be VBP www-nature-com-2208 111 10 no no RB www-nature-com-2208 111 11 longer long RBR www-nature-com-2208 111 12 available available JJ www-nature-com-2208 111 13 To to TO www-nature-com-2208 111 14 be be VB www-nature-com-2208 111 15 Interoperable interoperable JJ www-nature-com-2208 111 16 : : : 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www-nature-com-2208 119 11 precede precede VBP www-nature-com-2208 119 12 implementation implementation NN www-nature-com-2208 119 13 These these DT www-nature-com-2208 119 14 high high JJ www-nature-com-2208 119 15 - - HYPH www-nature-com-2208 119 16 level level NN www-nature-com-2208 119 17 FAIR fair NN www-nature-com-2208 119 18 Guiding Guiding NNP www-nature-com-2208 119 19 Principles Principles NNPS www-nature-com-2208 119 20 precede precede VBP www-nature-com-2208 119 21 implementation implementation NN www-nature-com-2208 119 22 choices choice NNS www-nature-com-2208 119 23 , , , www-nature-com-2208 119 24 and and CC www-nature-com-2208 119 25 do do VBP www-nature-com-2208 119 26 not not RB www-nature-com-2208 119 27 suggest suggest VB www-nature-com-2208 119 28 any any DT www-nature-com-2208 119 29 specific specific JJ www-nature-com-2208 119 30 technology technology NN www-nature-com-2208 119 31 , , , www-nature-com-2208 119 32 standard standard NN www-nature-com-2208 119 33 , , , www-nature-com-2208 119 34 or or CC www-nature-com-2208 119 35 implementation implementation NN www-nature-com-2208 119 36 - - HYPH www-nature-com-2208 119 37 solution solution NN www-nature-com-2208 119 38 ; ; : www-nature-com-2208 119 39 moreover moreover RB www-nature-com-2208 119 40 , , , www-nature-com-2208 119 41 the the DT www-nature-com-2208 119 42 Principles Principles NNPS www-nature-com-2208 119 43 are be VBP www-nature-com-2208 119 44 not not RB www-nature-com-2208 119 45 , , , www-nature-com-2208 119 46 themselves -PRON- PRP www-nature-com-2208 119 47 , , , www-nature-com-2208 119 48 a a DT www-nature-com-2208 119 49 standard standard NN www-nature-com-2208 119 50 or or CC www-nature-com-2208 119 51 a a DT www-nature-com-2208 119 52 specification specification NN www-nature-com-2208 119 53 . . . www-nature-com-2208 120 1 They -PRON- PRP www-nature-com-2208 120 2 act act VBP www-nature-com-2208 120 3 as as IN www-nature-com-2208 120 4 a a DT www-nature-com-2208 120 5 guide guide NN www-nature-com-2208 120 6 to to IN www-nature-com-2208 120 7 data data NN www-nature-com-2208 120 8 publishers publisher NNS www-nature-com-2208 120 9 and and CC www-nature-com-2208 120 10 stewards steward NNS www-nature-com-2208 120 11 to to TO www-nature-com-2208 120 12 assist assist VB www-nature-com-2208 120 13 them -PRON- PRP www-nature-com-2208 120 14 in in IN www-nature-com-2208 120 15 evaluating evaluate VBG www-nature-com-2208 120 16 whether whether IN www-nature-com-2208 120 17 their -PRON- PRP$ www-nature-com-2208 120 18 particular particular JJ www-nature-com-2208 120 19 implementation implementation NN www-nature-com-2208 120 20 choices choice NNS www-nature-com-2208 120 21 are be VBP www-nature-com-2208 120 22 rendering render VBG www-nature-com-2208 120 23 their -PRON- PRP$ www-nature-com-2208 120 24 digital digital JJ www-nature-com-2208 120 25 research research NN www-nature-com-2208 120 26 artefacts artefact VBZ www-nature-com-2208 120 27 Findable findable JJ www-nature-com-2208 120 28 , , , www-nature-com-2208 120 29 Accessible accessible JJ www-nature-com-2208 120 30 , , , www-nature-com-2208 120 31 Interoperable interoperable JJ www-nature-com-2208 120 32 , , , www-nature-com-2208 120 33 and and CC www-nature-com-2208 120 34 Reusable reusable JJ www-nature-com-2208 120 35 . . . www-nature-com-2208 121 1 We -PRON- PRP www-nature-com-2208 121 2 anticipate anticipate VBP www-nature-com-2208 121 3 that that IN www-nature-com-2208 121 4 these these DT www-nature-com-2208 121 5 high high JJ www-nature-com-2208 121 6 level level NN www-nature-com-2208 121 7 principles principle NNS www-nature-com-2208 121 8 will will MD www-nature-com-2208 121 9 enable enable VB www-nature-com-2208 121 10 a a DT www-nature-com-2208 121 11 broad broad JJ www-nature-com-2208 121 12 range range NN www-nature-com-2208 121 13 of of IN www-nature-com-2208 121 14 integrative integrative JJ www-nature-com-2208 121 15 and and CC www-nature-com-2208 121 16 exploratory exploratory JJ www-nature-com-2208 121 17 behaviours behaviour NNS www-nature-com-2208 121 18 , , , www-nature-com-2208 121 19 based base VBN www-nature-com-2208 121 20 on on IN www-nature-com-2208 121 21 a a DT www-nature-com-2208 121 22 wide wide JJ www-nature-com-2208 121 23 range range NN www-nature-com-2208 121 24 of of IN www-nature-com-2208 121 25 technology technology NN www-nature-com-2208 121 26 choices choice NNS www-nature-com-2208 121 27 and and CC www-nature-com-2208 121 28 implementations implementation NNS www-nature-com-2208 121 29 . . . www-nature-com-2208 122 1 Indeed indeed RB www-nature-com-2208 122 2 , , , www-nature-com-2208 122 3 many many JJ www-nature-com-2208 122 4 repositories repository NNS www-nature-com-2208 122 5 are be VBP www-nature-com-2208 122 6 already already RB www-nature-com-2208 122 7 implementing implement VBG www-nature-com-2208 122 8 various various JJ www-nature-com-2208 122 9 aspects aspect NNS www-nature-com-2208 122 10 of of 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institutional institutional JJ www-nature-com-2208 123 35 research research NN www-nature-com-2208 123 36 data datum NNS www-nature-com-2208 123 37 repositories repository NNS www-nature-com-2208 123 38 . . . www-nature-com-2208 124 1 Harvard Harvard NNP www-nature-com-2208 124 2 Dataverse Dataverse NNP www-nature-com-2208 124 3 , , , www-nature-com-2208 124 4 with with IN www-nature-com-2208 124 5 more more JJR www-nature-com-2208 124 6 than than IN www-nature-com-2208 124 7 60,000 60,000 CD www-nature-com-2208 124 8 datasets dataset NNS www-nature-com-2208 124 9 , , , www-nature-com-2208 124 10 is be VBZ www-nature-com-2208 124 11 the the DT www-nature-com-2208 124 12 largest large JJS www-nature-com-2208 124 13 of of IN www-nature-com-2208 124 14 the the DT www-nature-com-2208 124 15 current current JJ www-nature-com-2208 124 16 Dataverse Dataverse NNP www-nature-com-2208 124 17 repositories repository NNS www-nature-com-2208 124 18 , , , www-nature-com-2208 124 19 and and CC www-nature-com-2208 124 20 is be VBZ www-nature-com-2208 124 21 open open JJ www-nature-com-2208 124 22 to to IN www-nature-com-2208 124 23 all all DT www-nature-com-2208 124 24 researchers researcher NNS www-nature-com-2208 124 25 from from IN www-nature-com-2208 124 26 all all DT www-nature-com-2208 124 27 research research NN www-nature-com-2208 124 28 fields field NNS www-nature-com-2208 124 29 . . . www-nature-com-2208 125 1 Dataverse Dataverse NNP www-nature-com-2208 125 2 generates generate VBZ www-nature-com-2208 125 3 a a DT www-nature-com-2208 125 4 formal formal JJ www-nature-com-2208 125 5 citation citation NN www-nature-com-2208 125 6 for for IN www-nature-com-2208 125 7 each each DT www-nature-com-2208 125 8 deposit deposit NN www-nature-com-2208 125 9 , , , www-nature-com-2208 125 10 following follow VBG www-nature-com-2208 125 11 the the DT www-nature-com-2208 125 12 standard standard NN www-nature-com-2208 125 13 defined define VBN www-nature-com-2208 125 14 by by IN www-nature-com-2208 125 15 Altman Altman NNP www-nature-com-2208 125 16 and and CC www-nature-com-2208 125 17 King13 King13 NNP www-nature-com-2208 125 18 . . . www-nature-com-2208 126 1 Dataverse Dataverse NNP www-nature-com-2208 126 2 makes make VBZ www-nature-com-2208 126 3 the the DT www-nature-com-2208 126 4 Digital Digital NNP www-nature-com-2208 126 5 Object Object NNP www-nature-com-2208 126 6 Identifier Identifier NNP www-nature-com-2208 126 7 ( ( -LRB- www-nature-com-2208 126 8 DOI DOI NNP www-nature-com-2208 126 9 ) ) -RRB- www-nature-com-2208 126 10 , , , www-nature-com-2208 126 11 or or CC www-nature-com-2208 126 12 other other JJ www-nature-com-2208 126 13 persistent persistent JJ www-nature-com-2208 126 14 identifiers identifier NNS www-nature-com-2208 126 15 ( ( -LRB- www-nature-com-2208 126 16 Handles Handles NNP www-nature-com-2208 126 17 ) ) -RRB- www-nature-com-2208 126 18 , , , www-nature-com-2208 126 19 public public JJ www-nature-com-2208 126 20 when when WRB www-nature-com-2208 126 21 the the DT www-nature-com-2208 126 22 dataset dataset NN www-nature-com-2208 126 23 is be VBZ www-nature-com-2208 126 24 published publish VBN www-nature-com-2208 126 25 ( ( -LRB- www-nature-com-2208 126 26 ‘ ' `` www-nature-com-2208 126 27 F F NNP www-nature-com-2208 126 28 ’ ' '' www-nature-com-2208 126 29 ) ) -RRB- www-nature-com-2208 126 30 . . . www-nature-com-2208 127 1 This this DT www-nature-com-2208 127 2 resolves resolve VBZ www-nature-com-2208 127 3 to to IN www-nature-com-2208 127 4 a a DT www-nature-com-2208 127 5 landing landing NN www-nature-com-2208 127 6 page page NN www-nature-com-2208 127 7 , , , www-nature-com-2208 127 8 providing provide VBG www-nature-com-2208 127 9 access access NN www-nature-com-2208 127 10 to to IN www-nature-com-2208 127 11 metadata metadata NN www-nature-com-2208 127 12 , , , www-nature-com-2208 127 13 data data NN www-nature-com-2208 127 14 files file NNS www-nature-com-2208 127 15 , , , www-nature-com-2208 127 16 dataset dataset NN www-nature-com-2208 127 17 terms term NNS www-nature-com-2208 127 18 , , , www-nature-com-2208 127 19 waivers waiver NNS www-nature-com-2208 127 20 or or CC www-nature-com-2208 127 21 licenses license NNS www-nature-com-2208 127 22 , , , www-nature-com-2208 127 23 and and CC www-nature-com-2208 127 24 version version NN www-nature-com-2208 127 25 information information NN www-nature-com-2208 127 26 , , , www-nature-com-2208 127 27 all all DT www-nature-com-2208 127 28 of of IN www-nature-com-2208 127 29 which which WDT www-nature-com-2208 127 30 is be VBZ www-nature-com-2208 127 31 indexed index VBN www-nature-com-2208 127 32 and and CC www-nature-com-2208 127 33 searchable searchable JJ www-nature-com-2208 127 34 ( ( -LRB- www-nature-com-2208 127 35 ‘ ' `` www-nature-com-2208 127 36 F F NNP www-nature-com-2208 127 37 ’ ' '' www-nature-com-2208 127 38 , , , www-nature-com-2208 127 39 ‘ ' `` www-nature-com-2208 127 40 A a DT www-nature-com-2208 127 41 ’ ' '' www-nature-com-2208 127 42 , , , www-nature-com-2208 127 43 and and CC www-nature-com-2208 127 44 ‘ ' `` www-nature-com-2208 127 45 R r NN www-nature-com-2208 127 46 ’ ' '' www-nature-com-2208 127 47 ) ) -RRB- www-nature-com-2208 127 48 . . . www-nature-com-2208 128 1 Deposits deposit NNS www-nature-com-2208 128 2 include include VBP www-nature-com-2208 128 3 metadata metadata NN www-nature-com-2208 128 4 , , , www-nature-com-2208 128 5 data data NN www-nature-com-2208 128 6 files file NNS www-nature-com-2208 128 7 , , , www-nature-com-2208 128 8 and and CC www-nature-com-2208 128 9 any any DT www-nature-com-2208 128 10 complementary complementary JJ www-nature-com-2208 128 11 files file NNS www-nature-com-2208 128 12 ( ( -LRB- www-nature-com-2208 128 13 such such JJ www-nature-com-2208 128 14 as as IN www-nature-com-2208 128 15 documentation documentation NN www-nature-com-2208 128 16 or or CC www-nature-com-2208 128 17 code code NN www-nature-com-2208 128 18 ) ) -RRB- www-nature-com-2208 128 19 needed need VBN www-nature-com-2208 128 20 to to TO www-nature-com-2208 128 21 understand understand VB www-nature-com-2208 128 22 the the DT www-nature-com-2208 128 23 data datum NNS www-nature-com-2208 128 24 and and CC www-nature-com-2208 128 25 analysis analysis NN www-nature-com-2208 128 26 ( ( -LRB- www-nature-com-2208 128 27 ‘ ' `` www-nature-com-2208 128 28 R r NN www-nature-com-2208 128 29 ’ ' '' www-nature-com-2208 128 30 ) ) -RRB- www-nature-com-2208 128 31 . . . www-nature-com-2208 129 1 Metadata Metadata NNP www-nature-com-2208 129 2 is be VBZ www-nature-com-2208 129 3 always always RB www-nature-com-2208 129 4 public public JJ www-nature-com-2208 129 5 , , , www-nature-com-2208 129 6 even even RB www-nature-com-2208 129 7 if if IN www-nature-com-2208 129 8 the the DT www-nature-com-2208 129 9 data datum NNS www-nature-com-2208 129 10 are be VBP www-nature-com-2208 129 11 restricted restrict VBN www-nature-com-2208 129 12 or or CC www-nature-com-2208 129 13 removed remove VBN www-nature-com-2208 129 14 for for IN www-nature-com-2208 129 15 privacy privacy NN www-nature-com-2208 129 16 issues issue NNS www-nature-com-2208 129 17 ( ( -LRB- www-nature-com-2208 129 18 ‘ ' `` www-nature-com-2208 129 19 F f NN www-nature-com-2208 129 20 ’ ' '' www-nature-com-2208 129 21 , , , www-nature-com-2208 129 22 ‘ ' `` www-nature-com-2208 129 23 A a NN www-nature-com-2208 129 24 ’ ' '' www-nature-com-2208 129 25 ) ) -RRB- www-nature-com-2208 129 26 . . . www-nature-com-2208 130 1 This this DT www-nature-com-2208 130 2 metadata metadata NN www-nature-com-2208 130 3 is be VBZ www-nature-com-2208 130 4 offered offer VBN www-nature-com-2208 130 5 at at IN www-nature-com-2208 130 6 three three CD www-nature-com-2208 130 7 levels level NNS www-nature-com-2208 130 8 , , , www-nature-com-2208 130 9 extensively extensively RB www-nature-com-2208 130 10 supporting support VBG www-nature-com-2208 130 11 the the DT www-nature-com-2208 130 12 ‘ ' `` www-nature-com-2208 130 13 I -PRON- PRP www-nature-com-2208 130 14 ’ ' '' www-nature-com-2208 130 15 and and CC www-nature-com-2208 130 16 ‘ ' `` www-nature-com-2208 130 17 R r NN www-nature-com-2208 130 18 ’ ' '' www-nature-com-2208 130 19 FAIR FAIR NNP www-nature-com-2208 130 20 principles principle NNS www-nature-com-2208 130 21 : : : www-nature-com-2208 130 22 1 1 LS www-nature-com-2208 130 23 ) ) -RRB- www-nature-com-2208 130 24 data datum NNS www-nature-com-2208 130 25 citation citation NN www-nature-com-2208 130 26 metadata metadata NN www-nature-com-2208 130 27 , , , www-nature-com-2208 130 28 which which WDT www-nature-com-2208 130 29 maps map VBZ www-nature-com-2208 130 30 to to IN www-nature-com-2208 130 31 DataCite DataCite NNP www-nature-com-2208 130 32 schema schema NN www-nature-com-2208 130 33 or or CC www-nature-com-2208 130 34 Dublin Dublin NNP www-nature-com-2208 130 35 Core Core NNP www-nature-com-2208 130 36 Terms Terms NNP www-nature-com-2208 130 37 , , , www-nature-com-2208 130 38 2 2 LS www-nature-com-2208 130 39 ) ) -RRB- www-nature-com-2208 130 40 domain domain NN www-nature-com-2208 130 41 - - HYPH www-nature-com-2208 130 42 specific specific JJ www-nature-com-2208 130 43 metadata metadata NN www-nature-com-2208 130 44 , , , www-nature-com-2208 130 45 which which WDT www-nature-com-2208 130 46 when when WRB www-nature-com-2208 130 47 possible possible JJ www-nature-com-2208 130 48 maps map NNS www-nature-com-2208 130 49 to to TO www-nature-com-2208 130 50 metadata metadata VB www-nature-com-2208 130 51 standards standard NNS www-nature-com-2208 130 52 used use VBN www-nature-com-2208 130 53 within within IN www-nature-com-2208 130 54 a a DT www-nature-com-2208 130 55 scientific scientific JJ www-nature-com-2208 130 56 domain domain NN www-nature-com-2208 130 57 , , , www-nature-com-2208 130 58 and and CC www-nature-com-2208 130 59 3 3 LS www-nature-com-2208 130 60 ) ) -RRB- www-nature-com-2208 130 61 file file NN www-nature-com-2208 130 62 - - HYPH www-nature-com-2208 130 63 level level NN www-nature-com-2208 130 64 metadata metadata NN www-nature-com-2208 130 65 , , , www-nature-com-2208 130 66 which which WDT www-nature-com-2208 130 67 can can MD www-nature-com-2208 130 68 be be VB www-nature-com-2208 130 69 deep deep JJ www-nature-com-2208 130 70 and and CC www-nature-com-2208 130 71 extensive extensive JJ www-nature-com-2208 130 72 for for IN www-nature-com-2208 130 73 tabular tabular JJ www-nature-com-2208 130 74 data datum NNS www-nature-com-2208 130 75 files file NNS www-nature-com-2208 130 76 ( ( -LRB- www-nature-com-2208 130 77 including include VBG www-nature-com-2208 130 78 column column NN www-nature-com-2208 130 79 - - HYPH www-nature-com-2208 130 80 level level NN www-nature-com-2208 130 81 metadata metadata NN www-nature-com-2208 130 82 ) ) -RRB- www-nature-com-2208 130 83 . . . www-nature-com-2208 131 1 Finally finally RB www-nature-com-2208 131 2 , , , www-nature-com-2208 131 3 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27 to to TO www-nature-com-2208 131 28 grant grant VB www-nature-com-2208 131 29 access access NN www-nature-com-2208 131 30 when when WRB www-nature-com-2208 131 31 data data NN www-nature-com-2208 131 32 files file NNS www-nature-com-2208 131 33 are be VBP www-nature-com-2208 131 34 restricted restrict VBN www-nature-com-2208 131 35 ( ( -LRB- www-nature-com-2208 131 36 ‘ ' `` www-nature-com-2208 131 37 A a NN www-nature-com-2208 131 38 ’ ' '' www-nature-com-2208 131 39 ) ) -RRB- www-nature-com-2208 131 40 . . . www-nature-com-2208 132 1 FAIRDOM FAIRDOM NNP www-nature-com-2208 132 2 ( ( -LRB- www-nature-com-2208 132 3 http://fair-dom.org/about http://fair-dom.org/about NN www-nature-com-2208 132 4 ) ) -RRB- www-nature-com-2208 132 5 : : : www-nature-com-2208 132 6 integrates integrate VBZ www-nature-com-2208 132 7 the the DT www-nature-com-2208 132 8 SEEK14 seek14 JJ www-nature-com-2208 132 9 and and CC www-nature-com-2208 132 10 openBIS15 openbis15 JJ www-nature-com-2208 132 11 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www-nature-com-2208 139 60 research research NN www-nature-com-2208 139 61 objects18 objects18 NNP www-nature-com-2208 139 62 . . . www-nature-com-2208 140 1 Open open JJ www-nature-com-2208 140 2 PHACTS19 phacts19 NN www-nature-com-2208 140 3 : : : www-nature-com-2208 140 4 Open open JJ www-nature-com-2208 140 5 PHACTS PHACTS NNP www-nature-com-2208 140 6 is be VBZ www-nature-com-2208 140 7 a a DT www-nature-com-2208 140 8 data data NN www-nature-com-2208 140 9 integration integration NN www-nature-com-2208 140 10 platform platform NN www-nature-com-2208 140 11 for for IN www-nature-com-2208 140 12 information information NN www-nature-com-2208 140 13 pertaining pertain VBG www-nature-com-2208 140 14 to to IN www-nature-com-2208 140 15 drug drug NN www-nature-com-2208 140 16 discovery discovery NN www-nature-com-2208 140 17 . . . www-nature-com-2208 141 1 Access access NN www-nature-com-2208 141 2 to to IN www-nature-com-2208 141 3 the the DT www-nature-com-2208 141 4 platform platform NN www-nature-com-2208 141 5 is be VBZ www-nature-com-2208 141 6 mediated mediate VBN www-nature-com-2208 141 7 through through IN www-nature-com-2208 141 8 a a DT www-nature-com-2208 141 9 machine machine NN www-nature-com-2208 141 10 - - HYPH www-nature-com-2208 141 11 accessible accessible JJ www-nature-com-2208 141 12 interface20 interface20 NNP www-nature-com-2208 141 13 which which WDT www-nature-com-2208 141 14 provides provide VBZ www-nature-com-2208 141 15 multiple multiple JJ www-nature-com-2208 141 16 representations representation NNS www-nature-com-2208 141 17 that that WDT www-nature-com-2208 141 18 are be VBP www-nature-com-2208 141 19 both both DT www-nature-com-2208 141 20 human human JJ www-nature-com-2208 141 21 ( ( -LRB- www-nature-com-2208 141 22 HTML html NN www-nature-com-2208 141 23 ) ) -RRB- www-nature-com-2208 141 24 and and CC www-nature-com-2208 141 25 machine machine NN www-nature-com-2208 141 26 readable readable JJ www-nature-com-2208 141 27 ( ( -LRB- www-nature-com-2208 141 28 RDF RDF NNP www-nature-com-2208 141 29 , , , www-nature-com-2208 141 30 JSON JSON NNP www-nature-com-2208 141 31 , , , www-nature-com-2208 141 32 XML xml NN www-nature-com-2208 141 33 , , , www-nature-com-2208 141 34 CSV csv NN www-nature-com-2208 141 35 , , , www-nature-com-2208 141 36 etc etc FW www-nature-com-2208 141 37 ) ) -RRB- www-nature-com-2208 141 38 , , , www-nature-com-2208 141 39 providing provide VBG www-nature-com-2208 141 40 the the DT www-nature-com-2208 141 41 ‘ ' `` www-nature-com-2208 141 42 A a NN www-nature-com-2208 141 43 ’ ' '' www-nature-com-2208 141 44 facet facet NN www-nature-com-2208 141 45 of of IN www-nature-com-2208 141 46 FAIRness fairness NN www-nature-com-2208 141 47 . . . www-nature-com-2208 142 1 The the DT www-nature-com-2208 142 2 interface interface NN www-nature-com-2208 142 3 allows allow VBZ www-nature-com-2208 142 4 multiple multiple JJ www-nature-com-2208 142 5 URLs url NNS www-nature-com-2208 142 6 to to TO www-nature-com-2208 142 7 be be VB www-nature-com-2208 142 8 used use VBN www-nature-com-2208 142 9 to to TO www-nature-com-2208 142 10 access access VB www-nature-com-2208 142 11 information information NN www-nature-com-2208 142 12 about about IN www-nature-com-2208 142 13 a a DT www-nature-com-2208 142 14 particular particular JJ www-nature-com-2208 142 15 entity entity NN www-nature-com-2208 142 16 through through IN www-nature-com-2208 142 17 a a DT www-nature-com-2208 142 18 mappings mapping NNS www-nature-com-2208 142 19 service service NN www-nature-com-2208 142 20 ( ( -LRB- www-nature-com-2208 142 21 ‘ ' `` www-nature-com-2208 142 22 F F NNP www-nature-com-2208 142 23 ’ ' '' www-nature-com-2208 142 24 and and CC www-nature-com-2208 142 25 ‘ ' `` www-nature-com-2208 142 26 A a NN www-nature-com-2208 142 27 ’ ' '' www-nature-com-2208 142 28 ) ) -RRB- www-nature-com-2208 142 29 . . . www-nature-com-2208 143 1 Thus thus RB www-nature-com-2208 143 2 , , , www-nature-com-2208 143 3 a a DT www-nature-com-2208 143 4 user user NN www-nature-com-2208 143 5 can can MD www-nature-com-2208 143 6 provide provide VB www-nature-com-2208 143 7 a a DT www-nature-com-2208 143 8 ChEMBL chembl NN www-nature-com-2208 143 9 URL url NN www-nature-com-2208 143 10 to to TO www-nature-com-2208 143 11 retrieve retrieve VB www-nature-com-2208 143 12 information information NN www-nature-com-2208 143 13 sourced source VBN www-nature-com-2208 143 14 from from IN www-nature-com-2208 143 15 , , , www-nature-com-2208 143 16 for for IN www-nature-com-2208 143 17 example example NN www-nature-com-2208 143 18 , , , www-nature-com-2208 143 19 Chemspider Chemspider NNP www-nature-com-2208 143 20 or or CC www-nature-com-2208 143 21 DrugBank DrugBank NNP www-nature-com-2208 143 22 . . . www-nature-com-2208 144 1 Each each DT www-nature-com-2208 144 2 call call NN www-nature-com-2208 144 3 provides provide VBZ www-nature-com-2208 144 4 a a DT www-nature-com-2208 144 5 canonical canonical JJ www-nature-com-2208 144 6 URL url NN www-nature-com-2208 144 7 in in IN www-nature-com-2208 144 8 its -PRON- PRP$ www-nature-com-2208 144 9 response response NN www-nature-com-2208 144 10 ( ( -LRB- www-nature-com-2208 144 11 ‘ ' `` www-nature-com-2208 144 12 A a NN www-nature-com-2208 144 13 ’ ' '' www-nature-com-2208 144 14 and and CC www-nature-com-2208 144 15 ‘ ' `` www-nature-com-2208 144 16 I -PRON- PRP www-nature-com-2208 144 17 ’ ' '' www-nature-com-2208 144 18 ) ) -RRB- www-nature-com-2208 144 19 . . . www-nature-com-2208 145 1 All all DT www-nature-com-2208 145 2 data data NN www-nature-com-2208 145 3 sources source NNS www-nature-com-2208 145 4 used use VBN www-nature-com-2208 145 5 are be VBP www-nature-com-2208 145 6 described describe VBN www-nature-com-2208 145 7 using use VBG www-nature-com-2208 145 8 standardized standardized JJ www-nature-com-2208 145 9 dataset dataset NN www-nature-com-2208 145 10 descriptions description NNS www-nature-com-2208 145 11 , , , www-nature-com-2208 145 12 following follow VBG www-nature-com-2208 145 13 the the DT www-nature-com-2208 145 14 global global JJ www-nature-com-2208 145 15 VoID VoID NNP www-nature-com-2208 145 16 standard standard NN www-nature-com-2208 145 17 , , , www-nature-com-2208 145 18 with with IN www-nature-com-2208 145 19 rich rich JJ www-nature-com-2208 145 20 provenance provenance NN www-nature-com-2208 145 21 ( ( -LRB- www-nature-com-2208 145 22 ‘ ' `` www-nature-com-2208 145 23 R r NN www-nature-com-2208 145 24 ’ ' '' www-nature-com-2208 145 25 and and CC www-nature-com-2208 145 26 ‘ ' `` www-nature-com-2208 145 27 I -PRON- PRP www-nature-com-2208 145 28 ’ ' '' www-nature-com-2208 145 29 ) ) -RRB- www-nature-com-2208 145 30 . . . www-nature-com-2208 146 1 All all DT www-nature-com-2208 146 2 interface interface NN www-nature-com-2208 146 3 features feature NNS www-nature-com-2208 146 4 are be VBP www-nature-com-2208 146 5 described describe VBN www-nature-com-2208 146 6 using use VBG www-nature-com-2208 146 7 RDF RDF NNP www-nature-com-2208 146 8 following follow VBG www-nature-com-2208 146 9 the the DT www-nature-com-2208 146 10 Linked Linked NNP www-nature-com-2208 146 11 Data Data NNP www-nature-com-2208 146 12 API API NNP www-nature-com-2208 146 13 specification specification NN www-nature-com-2208 146 14 ( ( -LRB- www-nature-com-2208 146 15 ‘ ' `` www-nature-com-2208 146 16 A a NN www-nature-com-2208 146 17 ’ ' '' www-nature-com-2208 146 18 ) ) -RRB- www-nature-com-2208 146 19 . . . www-nature-com-2208 147 1 Finally finally RB www-nature-com-2208 147 2 , , , www-nature-com-2208 147 3 a a DT www-nature-com-2208 147 4 majority majority NN www-nature-com-2208 147 5 of of IN www-nature-com-2208 147 6 the the DT www-nature-com-2208 147 7 datasets dataset NNS www-nature-com-2208 147 8 are be VBP www-nature-com-2208 147 9 described describe VBN www-nature-com-2208 147 10 using use VBG www-nature-com-2208 147 11 community community NN www-nature-com-2208 147 12 agreed agree VBN www-nature-com-2208 147 13 upon upon IN www-nature-com-2208 147 14 ontologies ontology NNS www-nature-com-2208 147 15 ( ( -LRB- www-nature-com-2208 147 16 ‘ ' `` www-nature-com-2208 147 17 I -PRON- PRP www-nature-com-2208 147 18 ’ ' '' www-nature-com-2208 147 19 ) ) -RRB- www-nature-com-2208 147 20 . . . www-nature-com-2208 148 1 wwPDB4,21 wwPDB4,21 NNP www-nature-com-2208 148 2 : : : www-nature-com-2208 148 3 wwPDB wwpdb NN www-nature-com-2208 148 4 is be VBZ www-nature-com-2208 148 5 a a DT www-nature-com-2208 148 6 special special JJ www-nature-com-2208 148 7 - - HYPH www-nature-com-2208 148 8 purpose purpose NN www-nature-com-2208 148 9 , , , www-nature-com-2208 148 10 intensively intensively RB www-nature-com-2208 148 11 - - HYPH www-nature-com-2208 148 12 curated curate VBN www-nature-com-2208 148 13 data datum NNS www-nature-com-2208 148 14 archive archive NN www-nature-com-2208 148 15 that that WDT www-nature-com-2208 148 16 hosts host VBZ www-nature-com-2208 148 17 information information NN www-nature-com-2208 148 18 about about IN www-nature-com-2208 148 19 experimentally experimentally RB www-nature-com-2208 148 20 - - HYPH www-nature-com-2208 148 21 determined determine VBN www-nature-com-2208 148 22 3D 3d NN www-nature-com-2208 148 23 structures structure NNS www-nature-com-2208 148 24 of of IN www-nature-com-2208 148 25 proteins protein NNS www-nature-com-2208 148 26 and and CC www-nature-com-2208 148 27 nucleic nucleic JJ www-nature-com-2208 148 28 acids acid NNS www-nature-com-2208 148 29 . . . www-nature-com-2208 149 1 All all DT www-nature-com-2208 149 2 wwPDB wwpdb JJ www-nature-com-2208 149 3 entries entry NNS www-nature-com-2208 149 4 are be VBP www-nature-com-2208 149 5 stably stably RB www-nature-com-2208 149 6 hosted host VBN www-nature-com-2208 149 7 on on IN www-nature-com-2208 149 8 an an DT www-nature-com-2208 149 9 FTP FTP NNP www-nature-com-2208 149 10 server server NN www-nature-com-2208 149 11 ( ( -LRB- www-nature-com-2208 149 12 ‘ ' `` www-nature-com-2208 149 13 A a NN www-nature-com-2208 149 14 ’ ' '' www-nature-com-2208 149 15 ) ) -RRB- www-nature-com-2208 149 16 and and CC www-nature-com-2208 149 17 represented represent VBN www-nature-com-2208 149 18 in in IN www-nature-com-2208 149 19 machine machine NN www-nature-com-2208 149 20 - - HYPH www-nature-com-2208 149 21 readable readable JJ www-nature-com-2208 149 22 formats format NNS www-nature-com-2208 149 23 ( ( -LRB- www-nature-com-2208 149 24 text text NN www-nature-com-2208 149 25 and and CC www-nature-com-2208 149 26 XML xml NN www-nature-com-2208 149 27 ) ) -RRB- www-nature-com-2208 149 28 ; ; : www-nature-com-2208 149 29 the the DT www-nature-com-2208 149 30 latter latter JJ www-nature-com-2208 149 31 are be VBP www-nature-com-2208 149 32 machine machine NN www-nature-com-2208 149 33 - - HYPH www-nature-com-2208 149 34 actionable actionable JJ www-nature-com-2208 149 35 using use VBG www-nature-com-2208 149 36 the the DT www-nature-com-2208 149 37 metadata metadata NN www-nature-com-2208 149 38 provided provide VBN www-nature-com-2208 149 39 by by IN www-nature-com-2208 149 40 the the DT www-nature-com-2208 149 41 wwPDB wwpdb NN www-nature-com-2208 149 42 conforming conform VBG www-nature-com-2208 149 43 to to IN www-nature-com-2208 149 44 the the DT www-nature-com-2208 149 45 Macromolecular Macromolecular NNP www-nature-com-2208 149 46 Information Information NNP www-nature-com-2208 149 47 Framework Framework NNP www-nature-com-2208 149 48 ( ( -LRB- www-nature-com-2208 149 49 mmCIF22 mmCIF22 NNP www-nature-com-2208 149 50 ) ) -RRB- www-nature-com-2208 149 51 , , , www-nature-com-2208 149 52 a a DT www-nature-com-2208 149 53 data data NN www-nature-com-2208 149 54 standard standard NN www-nature-com-2208 149 55 of of IN www-nature-com-2208 149 56 the the DT www-nature-com-2208 149 57 International International NNP www-nature-com-2208 149 58 Union Union NNP www-nature-com-2208 149 59 of of IN www-nature-com-2208 149 60 Crystallography Crystallography NNP www-nature-com-2208 149 61 ( ( -LRB- www-nature-com-2208 149 62 IUCr IUCr NNPS www-nature-com-2208 149 63 ) ) -RRB- www-nature-com-2208 149 64 ( ( -LRB- www-nature-com-2208 149 65 ‘ ' `` www-nature-com-2208 149 66 F’,‘I F’,‘I NNP www-nature-com-2208 149 67 ’ ' '' www-nature-com-2208 149 68 for for IN www-nature-com-2208 149 69 humans human NNS www-nature-com-2208 149 70 , , , www-nature-com-2208 149 71 ‘ ' `` www-nature-com-2208 149 72 F’,‘I f’,‘i VB www-nature-com-2208 149 73 ’ ' '' www-nature-com-2208 149 74 for for IN www-nature-com-2208 149 75 IUCr IUCr NNS www-nature-com-2208 149 76 - - HYPH www-nature-com-2208 149 77 aware aware JJ www-nature-com-2208 149 78 machines machine NNS www-nature-com-2208 149 79 ) ) -RRB- www-nature-com-2208 149 80 . . . www-nature-com-2208 150 1 The the DT www-nature-com-2208 150 2 wwPDB wwpdb JJ www-nature-com-2208 150 3 metadata metadata NN www-nature-com-2208 150 4 contains contain VBZ www-nature-com-2208 150 5 cross cros NNS www-nature-com-2208 150 6 - - NNS www-nature-com-2208 150 7 references reference NNS www-nature-com-2208 150 8 to to IN www-nature-com-2208 150 9 common common JJ www-nature-com-2208 150 10 identifiers identifier NNS www-nature-com-2208 150 11 such such JJ www-nature-com-2208 150 12 as as IN www-nature-com-2208 150 13 PubMed PubMed NNP www-nature-com-2208 150 14 and and CC www-nature-com-2208 150 15 NCBI NCBI NNP www-nature-com-2208 150 16 Taxonomy Taxonomy NNP www-nature-com-2208 150 17 , , , www-nature-com-2208 150 18 and and CC www-nature-com-2208 150 19 their -PRON- PRP$ www-nature-com-2208 150 20 wwPDB wwpdb JJ www-nature-com-2208 150 21 metadata metadata NN www-nature-com-2208 150 22 are be VBP www-nature-com-2208 150 23 described describe VBN www-nature-com-2208 150 24 in in IN www-nature-com-2208 150 25 data datum NNS www-nature-com-2208 150 26 dictionaries dictionary NNS www-nature-com-2208 150 27 and and CC www-nature-com-2208 150 28 schema schema VB www-nature-com-2208 150 29 documents document NNS www-nature-com-2208 150 30 ( ( -LRB- www-nature-com-2208 150 31 http://mmcif.wwpdb.org http://mmcif.wwpdb.org NNP www-nature-com-2208 150 32 and and CC www-nature-com-2208 150 33 http://pdbml.wwpdb.org http://pdbml.wwpdb.org NNP www-nature-com-2208 150 34 ) ) -RRB- www-nature-com-2208 150 35 which which WDT www-nature-com-2208 150 36 conform conform VBP www-nature-com-2208 150 37 to to IN www-nature-com-2208 150 38 the the DT www-nature-com-2208 150 39 IUCr IUCr NNP www-nature-com-2208 150 40 data data NN www-nature-com-2208 150 41 standard standard NN www-nature-com-2208 150 42 for for IN www-nature-com-2208 150 43 the the DT www-nature-com-2208 150 44 chemical chemical JJ www-nature-com-2208 150 45 and and CC www-nature-com-2208 150 46 structural structural JJ www-nature-com-2208 150 47 biology biology NN www-nature-com-2208 150 48 domains domain NNS www-nature-com-2208 150 49 ( ( -LRB- www-nature-com-2208 150 50 ‘ ' `` www-nature-com-2208 150 51 R r NN www-nature-com-2208 150 52 ’ ' '' www-nature-com-2208 150 53 ) ) -RRB- www-nature-com-2208 150 54 . . . www-nature-com-2208 151 1 A a DT www-nature-com-2208 151 2 variety variety NN www-nature-com-2208 151 3 of of IN www-nature-com-2208 151 4 software software NN www-nature-com-2208 151 5 tools tool NNS www-nature-com-2208 151 6 are be VBP www-nature-com-2208 151 7 available available JJ www-nature-com-2208 151 8 to to TO www-nature-com-2208 151 9 interpret interpret VB www-nature-com-2208 151 10 both both DT www-nature-com-2208 151 11 wwPDB wwpdb JJ www-nature-com-2208 151 12 data datum NNS www-nature-com-2208 151 13 and and CC www-nature-com-2208 151 14 meta meta JJ www-nature-com-2208 151 15 - - HYPH www-nature-com-2208 151 16 data datum NNS www-nature-com-2208 151 17 ( ( -LRB- www-nature-com-2208 151 18 ‘ ' `` www-nature-com-2208 151 19 I’,‘R i’,‘r NN www-nature-com-2208 151 20 ’ ' '' www-nature-com-2208 151 21 for for IN www-nature-com-2208 151 22 humans human NNS www-nature-com-2208 151 23 , , , www-nature-com-2208 151 24 ‘ ' `` www-nature-com-2208 151 25 I’,‘R i’,‘r NN www-nature-com-2208 151 26 ’ ' '' www-nature-com-2208 151 27 for for IN www-nature-com-2208 151 28 machines machine NNS www-nature-com-2208 151 29 with with IN www-nature-com-2208 151 30 this this DT www-nature-com-2208 151 31 software software NN www-nature-com-2208 151 32 ) ) -RRB- www-nature-com-2208 151 33 . . . www-nature-com-2208 152 1 Each each DT www-nature-com-2208 152 2 entry entry NN www-nature-com-2208 152 3 is be VBZ www-nature-com-2208 152 4 represented represent VBN www-nature-com-2208 152 5 by by IN www-nature-com-2208 152 6 a a DT www-nature-com-2208 152 7 DOI DOI NNP www-nature-com-2208 152 8 ( ( -LRB- www-nature-com-2208 152 9 ‘ ' `` www-nature-com-2208 152 10 F F NNP www-nature-com-2208 152 11 ’ ' '' www-nature-com-2208 152 12 , , , www-nature-com-2208 152 13 ‘ ' `` www-nature-com-2208 152 14 A a DT www-nature-com-2208 152 15 ’ ' '' www-nature-com-2208 152 16 for for IN www-nature-com-2208 152 17 humans human NNS www-nature-com-2208 152 18 and and CC www-nature-com-2208 152 19 machines machine NNS www-nature-com-2208 152 20 ) ) -RRB- www-nature-com-2208 152 21 . . . www-nature-com-2208 153 1 The the DT www-nature-com-2208 153 2 DOI DOI NNP www-nature-com-2208 153 3 resolves resolve VBZ www-nature-com-2208 153 4 to to IN www-nature-com-2208 153 5 a a DT www-nature-com-2208 153 6 zipped zip VBN www-nature-com-2208 153 7 file file NN www-nature-com-2208 153 8 which which WDT www-nature-com-2208 153 9 requires require VBZ www-nature-com-2208 153 10 special special JJ www-nature-com-2208 153 11 software software NN www-nature-com-2208 153 12 for for IN www-nature-com-2208 153 13 further further JJ www-nature-com-2208 153 14 interrogation interrogation NN www-nature-com-2208 153 15 / / SYM www-nature-com-2208 153 16 interpretation interpretation NN www-nature-com-2208 153 17 . . . www-nature-com-2208 154 1 Other other JJ www-nature-com-2208 154 2 wwPDB wwpdb JJ www-nature-com-2208 154 3 access access NN www-nature-com-2208 154 4 points23–25 points23–25 NN www-nature-com-2208 154 5 provide provide VB www-nature-com-2208 154 6 access access NN www-nature-com-2208 154 7 to to IN www-nature-com-2208 154 8 wwPDB wwpdb JJ www-nature-com-2208 154 9 records record NNS www-nature-com-2208 154 10 through through IN www-nature-com-2208 154 11 URLs url NNS www-nature-com-2208 154 12 that that WDT www-nature-com-2208 154 13 are be VBP www-nature-com-2208 154 14 likely likely JJ www-nature-com-2208 154 15 to to TO www-nature-com-2208 154 16 be be VB www-nature-com-2208 154 17 stable stable JJ www-nature-com-2208 154 18 in in IN www-nature-com-2208 154 19 the the DT www-nature-com-2208 154 20 long long JJ www-nature-com-2208 154 21 - - HYPH www-nature-com-2208 154 22 term term NN www-nature-com-2208 154 23 ( ( -LRB- www-nature-com-2208 154 24 ‘ ' `` www-nature-com-2208 154 25 F F NNP www-nature-com-2208 154 26 ’ ' '' www-nature-com-2208 154 27 ) ) -RRB- www-nature-com-2208 154 28 , , , www-nature-com-2208 154 29 and and CC www-nature-com-2208 154 30 all all DT www-nature-com-2208 154 31 data datum NNS www-nature-com-2208 154 32 and and CC www-nature-com-2208 154 33 metadata metadata NN www-nature-com-2208 154 34 is be VBZ www-nature-com-2208 154 35 searchable searchable JJ www-nature-com-2208 154 36 through through IN www-nature-com-2208 154 37 one one CD www-nature-com-2208 154 38 or or CC www-nature-com-2208 154 39 more more JJR www-nature-com-2208 154 40 of of IN www-nature-com-2208 154 41 the the DT www-nature-com-2208 154 42 wwPDB wwpdb RB www-nature-com-2208 154 43 - - HYPH www-nature-com-2208 154 44 affiliated affiliate VBN www-nature-com-2208 154 45 websites website NNS www-nature-com-2208 154 46 ( ( -LRB- www-nature-com-2208 154 47 ‘ ' `` www-nature-com-2208 154 48 F F NNP www-nature-com-2208 154 49 ’ ' '' www-nature-com-2208 154 50 ) ) -RRB- www-nature-com-2208 154 51 UniProt26 UniProt26 NNP www-nature-com-2208 154 52 : : : www-nature-com-2208 154 53 UniProt UniProt NNP www-nature-com-2208 154 54 is be VBZ www-nature-com-2208 154 55 a a DT www-nature-com-2208 154 56 comprehensive comprehensive JJ www-nature-com-2208 154 57 resource resource NN www-nature-com-2208 154 58 for for IN www-nature-com-2208 154 59 protein protein NN www-nature-com-2208 154 60 sequence sequence NN www-nature-com-2208 154 61 and and CC www-nature-com-2208 154 62 annotation annotation NN www-nature-com-2208 154 63 data datum NNS www-nature-com-2208 154 64 . . . www-nature-com-2208 155 1 All all DT www-nature-com-2208 155 2 entries entry NNS www-nature-com-2208 155 3 are be VBP www-nature-com-2208 155 4 uniquely uniquely RB www-nature-com-2208 155 5 identified identify VBN www-nature-com-2208 155 6 by by IN www-nature-com-2208 155 7 a a DT www-nature-com-2208 155 8 stable stable JJ www-nature-com-2208 155 9 URL url NN www-nature-com-2208 155 10 , , , www-nature-com-2208 155 11 that that WDT www-nature-com-2208 155 12 provides provide VBZ www-nature-com-2208 155 13 access access NN www-nature-com-2208 155 14 to to IN www-nature-com-2208 155 15 the the DT www-nature-com-2208 155 16 record record NN www-nature-com-2208 155 17 in in IN www-nature-com-2208 155 18 a a DT www-nature-com-2208 155 19 variety variety NN www-nature-com-2208 155 20 of of IN www-nature-com-2208 155 21 formats format NNS www-nature-com-2208 155 22 including include VBG www-nature-com-2208 155 23 a a DT www-nature-com-2208 155 24 web web NN www-nature-com-2208 155 25 page page NN www-nature-com-2208 155 26 , , , www-nature-com-2208 155 27 plain plain JJ www-nature-com-2208 155 28 - - HYPH www-nature-com-2208 155 29 text text NN www-nature-com-2208 155 30 , , , www-nature-com-2208 155 31 and and CC www-nature-com-2208 155 32 RDF RDF NNP www-nature-com-2208 155 33 ( ( -LRB- www-nature-com-2208 155 34 ‘ ' `` www-nature-com-2208 155 35 F F NNP www-nature-com-2208 155 36 ’ ' '' www-nature-com-2208 155 37 and and CC www-nature-com-2208 155 38 ‘ ' `` www-nature-com-2208 155 39 A a NN www-nature-com-2208 155 40 ’ ' '' www-nature-com-2208 155 41 ) ) -RRB- www-nature-com-2208 155 42 . . . www-nature-com-2208 156 1 The the DT www-nature-com-2208 156 2 record record NN www-nature-com-2208 156 3 contains contain VBZ www-nature-com-2208 156 4 rich rich JJ www-nature-com-2208 156 5 metadata metadata NN www-nature-com-2208 156 6 ( ( -LRB- www-nature-com-2208 156 7 ‘ ' `` www-nature-com-2208 156 8 F F NNP www-nature-com-2208 156 9 ’ ' '' www-nature-com-2208 156 10 ) ) -RRB- www-nature-com-2208 156 11 that that DT www-nature-com-2208 156 12 is be VBZ www-nature-com-2208 156 13 both both CC www-nature-com-2208 156 14 human human JJ www-nature-com-2208 156 15 - - HYPH www-nature-com-2208 156 16 readable readable JJ www-nature-com-2208 156 17 ( ( -LRB- www-nature-com-2208 156 18 HTML html NN www-nature-com-2208 156 19 ) ) -RRB- www-nature-com-2208 156 20 and and CC www-nature-com-2208 156 21 machine machine NN www-nature-com-2208 156 22 - - HYPH www-nature-com-2208 156 23 readable readable JJ www-nature-com-2208 156 24 ( ( -LRB- www-nature-com-2208 156 25 text text NN www-nature-com-2208 156 26 and and CC www-nature-com-2208 156 27 RDF RDF NNP www-nature-com-2208 156 28 ) ) -RRB- www-nature-com-2208 156 29 , , , www-nature-com-2208 156 30 where where WRB www-nature-com-2208 156 31 the the DT www-nature-com-2208 156 32 RDF RDF NNP www-nature-com-2208 156 33 formatted format VBD www-nature-com-2208 156 34 response response NN www-nature-com-2208 156 35 utilizes utilize VBZ www-nature-com-2208 156 36 shared share VBN www-nature-com-2208 156 37 vocabularies vocabulary NNS www-nature-com-2208 156 38 and and CC www-nature-com-2208 156 39 ontologies ontology NNS www-nature-com-2208 156 40 such such JJ www-nature-com-2208 156 41 as as IN www-nature-com-2208 156 42 UniProt UniProt NNP www-nature-com-2208 156 43 Core Core NNP www-nature-com-2208 156 44 , , , www-nature-com-2208 156 45 FALDO FALDO NNP www-nature-com-2208 156 46 , , , www-nature-com-2208 156 47 and and CC www-nature-com-2208 156 48 ECO ECO NNP www-nature-com-2208 156 49 ( ( -LRB- www-nature-com-2208 156 50 ‘ ' `` www-nature-com-2208 156 51 I -PRON- PRP www-nature-com-2208 156 52 ’ ' '' www-nature-com-2208 156 53 ) ) -RRB- www-nature-com-2208 156 54 . . . www-nature-com-2208 157 1 Interlinking interlink VBG www-nature-com-2208 157 2 with with IN www-nature-com-2208 157 3 more more JJR www-nature-com-2208 157 4 than than IN www-nature-com-2208 157 5 150 150 CD www-nature-com-2208 157 6 different different JJ www-nature-com-2208 157 7 databases database NNS www-nature-com-2208 157 8 , , , www-nature-com-2208 157 9 every every DT www-nature-com-2208 157 10 UniProt UniProt NNP www-nature-com-2208 157 11 record record NN www-nature-com-2208 157 12 has have VBZ www-nature-com-2208 157 13 extensive extensive JJ www-nature-com-2208 157 14 links link NNS www-nature-com-2208 157 15 into into IN www-nature-com-2208 157 16 , , , www-nature-com-2208 157 17 for for IN www-nature-com-2208 157 18 example example NN www-nature-com-2208 157 19 , , , www-nature-com-2208 157 20 PubMed PubMed NNP www-nature-com-2208 157 21 , , , www-nature-com-2208 157 22 enabling enable VBG www-nature-com-2208 157 23 rich rich JJ www-nature-com-2208 157 24 citation citation NN www-nature-com-2208 157 25 . . . www-nature-com-2208 158 1 These these DT www-nature-com-2208 158 2 links link NNS www-nature-com-2208 158 3 are be VBP www-nature-com-2208 158 4 machine machine NN www-nature-com-2208 158 5 - - HYPH www-nature-com-2208 158 6 actionable actionable JJ www-nature-com-2208 158 7 in in IN www-nature-com-2208 158 8 the the DT www-nature-com-2208 158 9 RDF RDF NNP www-nature-com-2208 158 10 representation representation NN www-nature-com-2208 158 11 ( ( -LRB- www-nature-com-2208 158 12 ‘ ' `` www-nature-com-2208 158 13 R r NN www-nature-com-2208 158 14 ’ ' '' www-nature-com-2208 158 15 ) ) -RRB- www-nature-com-2208 158 16 . . . www-nature-com-2208 159 1 Finally finally RB www-nature-com-2208 159 2 , , , www-nature-com-2208 159 3 in in IN www-nature-com-2208 159 4 the the DT www-nature-com-2208 159 5 RDF RDF NNP www-nature-com-2208 159 6 representation representation NN www-nature-com-2208 159 7 , , , www-nature-com-2208 159 8 the the DT www-nature-com-2208 159 9 UniProt UniProt NNP www-nature-com-2208 159 10 Core Core NNP www-nature-com-2208 159 11 Ontology Ontology NNP www-nature-com-2208 159 12 explicitly explicitly RB www-nature-com-2208 159 13 types type VBZ www-nature-com-2208 159 14 all all DT www-nature-com-2208 159 15 records record NNS www-nature-com-2208 159 16 , , , www-nature-com-2208 159 17 leaving leave VBG www-nature-com-2208 159 18 no no DT www-nature-com-2208 159 19 ambiguity ambiguity NN www-nature-com-2208 159 20 — — : www-nature-com-2208 159 21 neither neither CC www-nature-com-2208 159 22 for for IN www-nature-com-2208 159 23 humans human NNS www-nature-com-2208 159 24 nor nor CC www-nature-com-2208 159 25 machines machine NNS www-nature-com-2208 159 26 — — : www-nature-com-2208 159 27 about about IN www-nature-com-2208 159 28 what what WP www-nature-com-2208 159 29 the the DT www-nature-com-2208 159 30 data datum NNS www-nature-com-2208 159 31 represents represent VBZ www-nature-com-2208 159 32 ( ( -LRB- www-nature-com-2208 159 33 ‘ ' `` www-nature-com-2208 159 34 R r NN www-nature-com-2208 159 35 ’ ' '' www-nature-com-2208 159 36 ) ) -RRB- www-nature-com-2208 159 37 , , , www-nature-com-2208 159 38 enabling enable VBG www-nature-com-2208 159 39 fully fully RB www-nature-com-2208 159 40 - - HYPH www-nature-com-2208 159 41 automated automate VBN www-nature-com-2208 159 42 retrieval retrieval NN www-nature-com-2208 159 43 of of IN www-nature-com-2208 159 44 records record NNS www-nature-com-2208 159 45 and and CC www-nature-com-2208 159 46 cross cross JJ www-nature-com-2208 159 47 - - JJ www-nature-com-2208 159 48 referencing referencing JJ www-nature-com-2208 159 49 information information NN www-nature-com-2208 159 50 . . . www-nature-com-2208 160 1 In in IN www-nature-com-2208 160 2 addition addition NN www-nature-com-2208 160 3 to to IN www-nature-com-2208 160 4 , , , www-nature-com-2208 160 5 and and CC www-nature-com-2208 160 6 in in IN www-nature-com-2208 160 7 support support NN www-nature-com-2208 160 8 of of IN www-nature-com-2208 160 9 , , , www-nature-com-2208 160 10 communities community NNS www-nature-com-2208 160 11 and and CC www-nature-com-2208 160 12 resources resource NNS www-nature-com-2208 160 13 that that WDT www-nature-com-2208 160 14 are be VBP www-nature-com-2208 160 15 already already RB www-nature-com-2208 160 16 pursuing pursue VBG www-nature-com-2208 160 17 FAIR FAIR NNP www-nature-com-2208 160 18 objectives objective NNS www-nature-com-2208 160 19 , , , www-nature-com-2208 160 20 the the DT www-nature-com-2208 160 21 Data Data NNP www-nature-com-2208 160 22 Citation Citation NNP www-nature-com-2208 160 23 Implementation Implementation NNP www-nature-com-2208 160 24 Group Group NNP www-nature-com-2208 160 25 of of IN www-nature-com-2208 160 26 Force11 Force11 NNP www-nature-com-2208 160 27 has have VBZ www-nature-com-2208 160 28 published publish VBN www-nature-com-2208 160 29 specific specific JJ www-nature-com-2208 160 30 technical technical JJ www-nature-com-2208 160 31 recommendations recommendation NNS www-nature-com-2208 160 32 for for IN www-nature-com-2208 160 33 how how WRB www-nature-com-2208 160 34 to to TO www-nature-com-2208 160 35 implement implement VB www-nature-com-2208 160 36 many many JJ www-nature-com-2208 160 37 of of IN www-nature-com-2208 160 38 the the DT www-nature-com-2208 160 39 principles27 principles27 NNPS www-nature-com-2208 160 40 , , , www-nature-com-2208 160 41 with with IN www-nature-com-2208 160 42 a a DT www-nature-com-2208 160 43 particular particular JJ www-nature-com-2208 160 44 focus focus NN www-nature-com-2208 160 45 on on IN www-nature-com-2208 160 46 identifiers identifier NNS www-nature-com-2208 160 47 and and CC www-nature-com-2208 160 48 their -PRON- PRP$ www-nature-com-2208 160 49 resolution resolution NN www-nature-com-2208 160 50 , , , www-nature-com-2208 160 51 persistence persistence NN www-nature-com-2208 160 52 , , , www-nature-com-2208 160 53 and and CC www-nature-com-2208 160 54 metadata metadata NN www-nature-com-2208 160 55 accessibility accessibility NN www-nature-com-2208 160 56 especially especially RB www-nature-com-2208 160 57 related relate VBN www-nature-com-2208 160 58 to to IN www-nature-com-2208 160 59 citation citation NN www-nature-com-2208 160 60 . . . www-nature-com-2208 161 1 In in IN www-nature-com-2208 161 2 addition addition NN www-nature-com-2208 161 3 , , , www-nature-com-2208 161 4 the the DT www-nature-com-2208 161 5 ‘ ' `` www-nature-com-2208 161 6 Skunkworks Skunkworks NNP www-nature-com-2208 161 7 ’ ’ POS www-nature-com-2208 161 8 group group NN www-nature-com-2208 161 9 that that WDT www-nature-com-2208 161 10 emerged emerge VBD www-nature-com-2208 161 11 from from IN www-nature-com-2208 161 12 the the DT www-nature-com-2208 161 13 Lorentz Lorentz NNP www-nature-com-2208 161 14 Workshop Workshop NNP www-nature-com-2208 161 15 has have VBZ www-nature-com-2208 161 16 been be VBN www-nature-com-2208 161 17 creating create VBG www-nature-com-2208 161 18 software software NN www-nature-com-2208 161 19 supporting support VBG www-nature-com-2208 161 20 infrastructures28 infrastructures28 NNS www-nature-com-2208 161 21 that that WDT www-nature-com-2208 161 22 are be VBP www-nature-com-2208 161 23 , , , www-nature-com-2208 161 24 end end NN www-nature-com-2208 161 25 - - HYPH www-nature-com-2208 161 26 to to IN www-nature-com-2208 161 27 - - HYPH www-nature-com-2208 161 28 end end NN www-nature-com-2208 161 29 , , , www-nature-com-2208 161 30 compatible compatible JJ www-nature-com-2208 161 31 with with IN www-nature-com-2208 161 32 FAIR FAIR NNP www-nature-com-2208 161 33 principles principle NNS www-nature-com-2208 161 34 , , , www-nature-com-2208 161 35 and and CC www-nature-com-2208 161 36 can can MD www-nature-com-2208 161 37 be be VB www-nature-com-2208 161 38 implemented implement VBN www-nature-com-2208 161 39 over over IN www-nature-com-2208 161 40 existing exist VBG www-nature-com-2208 161 41 repositories repository NNS www-nature-com-2208 161 42 . . . www-nature-com-2208 162 1 These these DT www-nature-com-2208 162 2 code code NN www-nature-com-2208 162 3 modules module NNS www-nature-com-2208 162 4 have have VBP www-nature-com-2208 162 5 a a DT www-nature-com-2208 162 6 particular particular JJ www-nature-com-2208 162 7 focus focus NN www-nature-com-2208 162 8 on on IN www-nature-com-2208 162 9 metadata metadata NN www-nature-com-2208 162 10 publication publication NN www-nature-com-2208 162 11 and and CC www-nature-com-2208 162 12 searchability searchability NN www-nature-com-2208 162 13 , , , www-nature-com-2208 162 14 compatibility compatibility NN www-nature-com-2208 162 15 in in IN www-nature-com-2208 162 16 cases case NNS www-nature-com-2208 162 17 of of IN www-nature-com-2208 162 18 strict strict JJ www-nature-com-2208 162 19 privacy privacy NN www-nature-com-2208 162 20 considerations consideration NNS www-nature-com-2208 162 21 , , , www-nature-com-2208 162 22 and and CC www-nature-com-2208 162 23 the the DT www-nature-com-2208 162 24 extremely extremely RB www-nature-com-2208 162 25 difficult difficult JJ www-nature-com-2208 162 26 problem problem NN www-nature-com-2208 162 27 of of IN www-nature-com-2208 162 28 data datum NNS www-nature-com-2208 162 29 and and CC www-nature-com-2208 162 30 metadata metadata NN www-nature-com-2208 162 31 interoperability interoperability NN www-nature-com-2208 162 32 ( ( -LRB- www-nature-com-2208 162 33 manuscript manuscript NNP www-nature-com-2208 162 34 in in IN www-nature-com-2208 162 35 preparation preparation NN www-nature-com-2208 162 36 ) ) -RRB- www-nature-com-2208 162 37 . . . www-nature-com-2208 163 1 Finally finally RB www-nature-com-2208 163 2 , , , www-nature-com-2208 163 3 there there EX www-nature-com-2208 163 4 are be VBP www-nature-com-2208 163 5 several several JJ www-nature-com-2208 163 6 emergent emergent JJ www-nature-com-2208 163 7 projects project NNS www-nature-com-2208 163 8 , , , www-nature-com-2208 163 9 some some DT www-nature-com-2208 163 10 listed list VBN www-nature-com-2208 163 11 in in IN www-nature-com-2208 163 12 Box Box NNP www-nature-com-2208 163 13 3 3 CD www-nature-com-2208 163 14 , , , www-nature-com-2208 163 15 for for IN www-nature-com-2208 163 16 which which WDT www-nature-com-2208 163 17 FAIR FAIR NNP www-nature-com-2208 163 18 is be VBZ www-nature-com-2208 163 19 a a DT www-nature-com-2208 163 20 key key JJ www-nature-com-2208 163 21 objective objective NN www-nature-com-2208 163 22 . . . www-nature-com-2208 164 1 These these DT www-nature-com-2208 164 2 projects project NNS www-nature-com-2208 164 3 may may MD www-nature-com-2208 164 4 provide provide VB www-nature-com-2208 164 5 valuable valuable JJ www-nature-com-2208 164 6 advice advice NN www-nature-com-2208 164 7 and and CC www-nature-com-2208 164 8 guidance guidance NN www-nature-com-2208 164 9 for for IN www-nature-com-2208 164 10 those those DT www-nature-com-2208 164 11 wishing wish VBG www-nature-com-2208 164 12 to to TO www-nature-com-2208 164 13 become become VB www-nature-com-2208 164 14 more more JJR www-nature-com-2208 164 15 FAIR FAIR NNP www-nature-com-2208 164 16 . . . www-nature-com-2208 165 1 Box Box NNP www-nature-com-2208 165 2 3 3 CD www-nature-com-2208 165 3 : : : www-nature-com-2208 165 4 Emergent emergent JJ www-nature-com-2208 165 5 community community NN www-nature-com-2208 165 6 / / SYM www-nature-com-2208 165 7 collaborative collaborative JJ www-nature-com-2208 165 8 initiatives initiative NNS www-nature-com-2208 165 9 with with IN www-nature-com-2208 165 10 FAIR FAIR NNP www-nature-com-2208 165 11 as as IN www-nature-com-2208 165 12 a a DT www-nature-com-2208 165 13 core core NN www-nature-com-2208 165 14 focus focus NN www-nature-com-2208 165 15 or or CC www-nature-com-2208 165 16 activity activity NN www-nature-com-2208 165 17 bioCADDIE biocaddie NN www-nature-com-2208 165 18 ( ( -LRB- www-nature-com-2208 165 19 https://biocaddie.org https://biocaddie.org NNP www-nature-com-2208 165 20 ) ) -RRB- www-nature-com-2208 165 21 : : : www-nature-com-2208 165 22 The the DT www-nature-com-2208 165 23 NIH NIH NNP www-nature-com-2208 165 24 BD2 BD2 NNP www-nature-com-2208 165 25 K K NNP www-nature-com-2208 165 26 biomedical biomedical JJ www-nature-com-2208 165 27 and and CC www-nature-com-2208 165 28 healthCAre healthCAre NNP www-nature-com-2208 165 29 Data Data NNP www-nature-com-2208 165 30 Discovery Discovery NNP www-nature-com-2208 165 31 Index Index NNP www-nature-com-2208 165 32 Ecosystem Ecosystem NNP www-nature-com-2208 165 33 ( ( -LRB- www-nature-com-2208 165 34 bioCADDIE bioCADDIE NNP www-nature-com-2208 165 35 ) ) -RRB- www-nature-com-2208 165 36 consortium consortium NN www-nature-com-2208 165 37 works work VBZ www-nature-com-2208 165 38 to to TO www-nature-com-2208 165 39 develop develop VB www-nature-com-2208 165 40 a a DT www-nature-com-2208 165 41 Data Data NNP www-nature-com-2208 165 42 Discovery Discovery NNP www-nature-com-2208 165 43 Index Index NNP www-nature-com-2208 165 44 ( ( -LRB- www-nature-com-2208 165 45 DDI DDI NNP www-nature-com-2208 165 46 ) ) -RRB- www-nature-com-2208 165 47 prototype prototype NN www-nature-com-2208 165 48 , , , www-nature-com-2208 165 49 which which WDT www-nature-com-2208 165 50 is be VBZ www-nature-com-2208 165 51 set set VBN www-nature-com-2208 165 52 to to TO www-nature-com-2208 165 53 be be VB www-nature-com-2208 165 54 as as RB www-nature-com-2208 165 55 transformative transformative JJ www-nature-com-2208 165 56 and and CC www-nature-com-2208 165 57 impactful impactful JJ www-nature-com-2208 165 58 for for IN www-nature-com-2208 165 59 data datum NNS www-nature-com-2208 165 60 as as IN www-nature-com-2208 165 61 PubMed PubMed NNP www-nature-com-2208 165 62 for for IN www-nature-com-2208 165 63 the the DT www-nature-com-2208 165 64 biomedical biomedical JJ www-nature-com-2208 165 65 literature30 literature30 NN www-nature-com-2208 165 66 . . . www-nature-com-2208 166 1 The the DT www-nature-com-2208 166 2 DDI DDI NNP www-nature-com-2208 166 3 focuses focus VBZ www-nature-com-2208 166 4 on on IN www-nature-com-2208 166 5 finding find VBG www-nature-com-2208 166 6 ( ( -LRB- www-nature-com-2208 166 7 ‘ ' `` www-nature-com-2208 166 8 F F NNP www-nature-com-2208 166 9 ’ ' '' www-nature-com-2208 166 10 ) ) -RRB- www-nature-com-2208 166 11 and and CC www-nature-com-2208 166 12 accessing access VBG www-nature-com-2208 166 13 ( ( -LRB- www-nature-com-2208 166 14 ‘ ' `` www-nature-com-2208 166 15 A a NN www-nature-com-2208 166 16 ’ ' '' www-nature-com-2208 166 17 ) ) -RRB- www-nature-com-2208 166 18 the the DT www-nature-com-2208 166 19 datasets dataset NNS www-nature-com-2208 166 20 stored store VBN www-nature-com-2208 166 21 across across IN www-nature-com-2208 166 22 different different JJ www-nature-com-2208 166 23 sources source NNS www-nature-com-2208 166 24 , , , www-nature-com-2208 166 25 and and CC www-nature-com-2208 166 26 progressively progressively RB www-nature-com-2208 166 27 works work VBZ www-nature-com-2208 166 28 to to TO www-nature-com-2208 166 29 identify identify VB www-nature-com-2208 166 30 relevant relevant JJ www-nature-com-2208 166 31 metadata31 metadata31 NNP www-nature-com-2208 166 32 ( ( -LRB- www-nature-com-2208 166 33 ‘ ' `` www-nature-com-2208 166 34 I -PRON- PRP www-nature-com-2208 166 35 ’ ' '' www-nature-com-2208 166 36 ) ) -RRB- www-nature-com-2208 166 37 and and CC www-nature-com-2208 166 38 maps map VBZ www-nature-com-2208 166 39 them -PRON- PRP www-nature-com-2208 166 40 to to IN www-nature-com-2208 166 41 community community NN www-nature-com-2208 166 42 standards standard NNS www-nature-com-2208 166 43 ( ( -LRB- www-nature-com-2208 166 44 ‘ ' `` www-nature-com-2208 166 45 R r NN www-nature-com-2208 166 46 ’ ' '' www-nature-com-2208 166 47 ) ) -RRB- www-nature-com-2208 166 48 , , , www-nature-com-2208 166 49 linking link VBG www-nature-com-2208 166 50 to to IN www-nature-com-2208 166 51 BioSharing BioSharing NNP www-nature-com-2208 166 52 . . . www-nature-com-2208 167 1 CEDAR32 cedar32 NN www-nature-com-2208 167 2 : : : www-nature-com-2208 167 3 The the DT www-nature-com-2208 167 4 Center Center NNP www-nature-com-2208 167 5 for for IN www-nature-com-2208 167 6 Expanded Expanded NNP www-nature-com-2208 167 7 Data Data NNP www-nature-com-2208 167 8 Annotation Annotation NNP www-nature-com-2208 167 9 and and CC www-nature-com-2208 167 10 Retrieval Retrieval NNP www-nature-com-2208 167 11 ( ( -LRB- www-nature-com-2208 167 12 CEDAR CEDAR NNP www-nature-com-2208 167 13 ) ) -RRB- www-nature-com-2208 167 14 is be VBZ www-nature-com-2208 167 15 an an DT www-nature-com-2208 167 16 NIH NIH NNP www-nature-com-2208 167 17 BD2 BD2 NNP www-nature-com-2208 167 18 K K NNP www-nature-com-2208 167 19 funded fund VBD www-nature-com-2208 167 20 center center NN www-nature-com-2208 167 21 of of IN www-nature-com-2208 167 22 excellence excellence NN www-nature-com-2208 167 23 to to TO www-nature-com-2208 167 24 develop develop VB www-nature-com-2208 167 25 tools tool NNS www-nature-com-2208 167 26 and and CC www-nature-com-2208 167 27 technologies technology NNS www-nature-com-2208 167 28 that that WDT www-nature-com-2208 167 29 reduce reduce VBP www-nature-com-2208 167 30 the the DT www-nature-com-2208 167 31 burden burden NN www-nature-com-2208 167 32 of of IN www-nature-com-2208 167 33 authoring author VBG www-nature-com-2208 167 34 and and CC www-nature-com-2208 167 35 enhancing enhance VBG www-nature-com-2208 167 36 metadata metadata NN www-nature-com-2208 167 37 that that WDT www-nature-com-2208 167 38 meet meet VBP www-nature-com-2208 167 39 community community NN www-nature-com-2208 167 40 - - HYPH www-nature-com-2208 167 41 based base VBN www-nature-com-2208 167 42 standards standard NNS www-nature-com-2208 167 43 . . . www-nature-com-2208 168 1 CEDAR CEDAR NNP www-nature-com-2208 168 2 will will MD www-nature-com-2208 168 3 enable enable VB www-nature-com-2208 168 4 the the DT www-nature-com-2208 168 5 creation creation NN www-nature-com-2208 168 6 of of IN www-nature-com-2208 168 7 metadata metadata NN www-nature-com-2208 168 8 templates template NNS www-nature-com-2208 168 9 that that WDT www-nature-com-2208 168 10 implement implement VBP www-nature-com-2208 168 11 community community NN www-nature-com-2208 168 12 based base VBN www-nature-com-2208 168 13 standards standard NNS www-nature-com-2208 168 14 for for IN www-nature-com-2208 168 15 experimental experimental JJ www-nature-com-2208 168 16 metadata metadata NN www-nature-com-2208 168 17 , , , www-nature-com-2208 168 18 from from IN www-nature-com-2208 168 19 BioSharing BioSharing NNP www-nature-com-2208 168 20 ( ( -LRB- www-nature-com-2208 168 21 https://biosharing.org https://biosharing.org NNP www-nature-com-2208 168 22 ) ) -RRB- www-nature-com-2208 168 23 , , , www-nature-com-2208 168 24 and and CC www-nature-com-2208 168 25 that that DT www-nature-com-2208 168 26 will will MD www-nature-com-2208 168 27 be be VB www-nature-com-2208 168 28 uniquely uniquely RB www-nature-com-2208 168 29 identifiable identifiable JJ www-nature-com-2208 168 30 and and CC www-nature-com-2208 168 31 retrievable retrievable VB www-nature-com-2208 168 32 with with IN www-nature-com-2208 168 33 HTTP http JJ www-nature-com-2208 168 34 URIs uri NNS www-nature-com-2208 168 35 , , , www-nature-com-2208 168 36 and and CC www-nature-com-2208 168 37 annotated annotate VBN www-nature-com-2208 168 38 with with IN www-nature-com-2208 168 39 vocabularies vocabulary NNS www-nature-com-2208 168 40 and and CC www-nature-com-2208 168 41 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, , , www-nature-com-2208 171 5 among among IN www-nature-com-2208 171 6 others other NNS www-nature-com-2208 171 7 , , , www-nature-com-2208 171 8 provide provide VB www-nature-com-2208 171 9 tools tool NNS www-nature-com-2208 171 10 and and CC www-nature-com-2208 171 11 or or CC www-nature-com-2208 171 12 collaborative collaborative JJ www-nature-com-2208 171 13 opportunities opportunity NNS www-nature-com-2208 171 14 for for IN www-nature-com-2208 171 15 those those DT www-nature-com-2208 171 16 who who WP www-nature-com-2208 171 17 wish wish VBP www-nature-com-2208 171 18 to to TO www-nature-com-2208 171 19 improve improve VB www-nature-com-2208 171 20 the the DT www-nature-com-2208 171 21 FAIRness fairness NN www-nature-com-2208 171 22 of of IN www-nature-com-2208 171 23 their -PRON- PRP$ www-nature-com-2208 171 24 data datum NNS www-nature-com-2208 171 25 . . . www-nature-com-2208 172 1 FAIRness fairness NN www-nature-com-2208 172 2 is be VBZ www-nature-com-2208 172 3 a a DT 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www-nature-com-2208 172 27 previous previous JJ www-nature-com-2208 172 28 work work NN www-nature-com-2208 172 29 by by IN www-nature-com-2208 172 30 both both PDT www-nature-com-2208 172 31 the the DT www-nature-com-2208 172 32 Concept Concept NNP www-nature-com-2208 172 33 Web Web NNP www-nature-com-2208 172 34 Alliance Alliance NNP www-nature-com-2208 172 35 ( ( -LRB- www-nature-com-2208 172 36 https://conceptweblog.wordpress.com/ https://conceptweblog.wordpress.com/ NNP www-nature-com-2208 172 37 ) ) -RRB- www-nature-com-2208 172 38 partners partner NNS www-nature-com-2208 172 39 , , , www-nature-com-2208 172 40 who who WP www-nature-com-2208 172 41 focused focus VBD www-nature-com-2208 172 42 on on IN www-nature-com-2208 172 43 machine machine NN www-nature-com-2208 172 44 - - HYPH www-nature-com-2208 172 45 actionability actionability NN www-nature-com-2208 172 46 and and CC www-nature-com-2208 172 47 harmonization harmonization NN www-nature-com-2208 172 48 of of IN www-nature-com-2208 172 49 data datum NNS www-nature-com-2208 172 50 structures structure NNS www-nature-com-2208 172 51 and and CC www-nature-com-2208 172 52 semantics semantic NNS www-nature-com-2208 172 53 , , , www-nature-com-2208 172 54 and and CC www-nature-com-2208 172 55 by by IN www-nature-com-2208 172 56 the the DT www-nature-com-2208 172 57 scientific scientific JJ www-nature-com-2208 172 58 and and CC www-nature-com-2208 172 59 scholarly scholarly JJ www-nature-com-2208 172 60 organizations organization NNS www-nature-com-2208 172 61 that that WDT www-nature-com-2208 172 62 developed develop VBD www-nature-com-2208 172 63 the the DT www-nature-com-2208 172 64 Joint Joint NNP www-nature-com-2208 172 65 Declaration Declaration NNP www-nature-com-2208 172 66 of of IN www-nature-com-2208 172 67 Data Data NNP www-nature-com-2208 172 68 Citation Citation NNP www-nature-com-2208 172 69 Principles Principles NNPS www-nature-com-2208 172 70 ( ( -LRB- www-nature-com-2208 172 71 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www-nature-com-2208 179 7 to to TO www-nature-com-2208 179 8 be be VB www-nature-com-2208 179 9 Findable findable JJ www-nature-com-2208 179 10 , , , www-nature-com-2208 179 11 Accessible accessible JJ www-nature-com-2208 179 12 , , , www-nature-com-2208 179 13 Interoperable interoperable JJ www-nature-com-2208 179 14 , , , www-nature-com-2208 179 15 and and CC www-nature-com-2208 179 16 Reusable reusable VB www-nature-com-2208 179 17 in in IN www-nature-com-2208 179 18 the the DT www-nature-com-2208 179 19 long long JJ www-nature-com-2208 179 20 - - HYPH www-nature-com-2208 179 21 term term NN www-nature-com-2208 179 22 , , , www-nature-com-2208 179 23 and and CC www-nature-com-2208 179 24 these these DT www-nature-com-2208 179 25 objectives objective NNS www-nature-com-2208 179 26 are be VBP www-nature-com-2208 179 27 rapidly rapidly RB www-nature-com-2208 179 28 becoming become VBG www-nature-com-2208 179 29 expectations expectation NNS www-nature-com-2208 179 30 of of IN 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www-nature-com-2208 184 8 : : : www-nature-com-2208 184 9 Wilkinson Wilkinson NNP www-nature-com-2208 184 10 , , , www-nature-com-2208 184 11 M. M. NNP www-nature-com-2208 184 12 D. D. NNP www-nature-com-2208 184 13 et et NNP www-nature-com-2208 184 14 al al NNP www-nature-com-2208 184 15 . . . www-nature-com-2208 185 1 The the DT www-nature-com-2208 185 2 FAIR FAIR NNP www-nature-com-2208 185 3 Guiding Guiding NNP www-nature-com-2208 185 4 Principles Principles NNPS www-nature-com-2208 185 5 for for IN www-nature-com-2208 185 6 scientific scientific JJ www-nature-com-2208 185 7 data data NN www-nature-com-2208 185 8 management management NN www-nature-com-2208 185 9 and and CC www-nature-com-2208 185 10 stewardship stewardship NN www-nature-com-2208 185 11 . . . www-nature-com-2208 186 1 Sci Sci NNP www-nature-com-2208 186 2 . . . www-nature-com-2208 187 1 Data datum NNS www-nature-com-2208 187 2 3:160018 3:160018 NNPS www-nature-com-2208 187 3 doi doi NN www-nature-com-2208 187 4 : : : www-nature-com-2208 187 5 10.1038 10.1038 CD www-nature-com-2208 187 6 / / SYM www-nature-com-2208 187 7 sdata.2016.18 sdata.2016.18 NNP www-nature-com-2208 187 8 ( ( -LRB- www-nature-com-2208 187 9 2016 2016 CD www-nature-com-2208 187 10 ) ) -RRB- www-nature-com-2208 187 11 . . . www-nature-com-2208 188 1 References reference NNS www-nature-com-2208 188 2 1Roche 1Roche NNP www-nature-com-2208 188 3 , , , www-nature-com-2208 188 4 D. 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NNP www-nature-com-2208 189 1 Public Public NNP www-nature-com-2208 189 2 Data Data NNP www-nature-com-2208 189 3 Archiving archive VBG www-nature-com-2208 189 4 in in IN www-nature-com-2208 189 5 Ecology Ecology NNP www-nature-com-2208 189 6 and and CC www-nature-com-2208 189 7 Evolution Evolution NNP www-nature-com-2208 189 8 : : : www-nature-com-2208 189 9 How how WRB www-nature-com-2208 189 10 Well well UH www-nature-com-2208 189 11 Are be VBP www-nature-com-2208 189 12 We -PRON- PRP www-nature-com-2208 189 13 Doing do VBG www-nature-com-2208 189 14 ? ? . www-nature-com-2208 190 1 PLOS PLOS NNP www-nature-com-2208 190 2 Biol Biol NNP www-nature-com-2208 190 3 . . . www-nature-com-2208 191 1 13 13 CD www-nature-com-2208 191 2 , , , www-nature-com-2208 191 3 e1002295 e1002295 NNP www-nature-com-2208 191 4 ( ( -LRB- www-nature-com-2208 191 5 2015 2015 CD www-nature-com-2208 191 6 ) ) -RRB- www-nature-com-2208 191 7 . . . www-nature-com-2208 192 1 Article Article NNP www-nature-com-2208 192 2     _SP www-nature-com-2208 192 3 Google Google NNP www-nature-com-2208 192 4 Scholar Scholar NNP www-nature-com-2208 192 5     _SP www-nature-com-2208 192 6 2Bechhofer 2Bechhofer NNP www-nature-com-2208 192 7 , , , www-nature-com-2208 192 8 S. S. NNP www-nature-com-2208 192 9 et et NNP www-nature-com-2208 192 10 al al NNP www-nature-com-2208 192 11 . . . www-nature-com-2208 193 1 Research research NN www-nature-com-2208 193 2 Objects object NNS www-nature-com-2208 193 3 : : : www-nature-com-2208 193 4 Towards towards IN www-nature-com-2208 193 5 Exchange Exchange NNP www-nature-com-2208 193 6 and and CC www-nature-com-2208 193 7 Reuse Reuse NNP www-nature-com-2208 193 8 of of IN www-nature-com-2208 193 9 Digital Digital NNP www-nature-com-2208 193 10 Knowledge Knowledge NNP www-nature-com-2208 193 11 . . . www-nature-com-2208 194 1 Nat Nat NNP www-nature-com-2208 194 2 . . . www-nature-com-2208 195 1 Preced prece VBN www-nature-com-2208 195 2 . . . www-nature-com-2208 196 1 10.1038 10.1038 CD www-nature-com-2208 196 2 / / SYM www-nature-com-2208 196 3 npre.2010.4626.1 npre.2010.4626.1 CD www-nature-com-2208 196 4 ( ( -LRB- www-nature-com-2208 196 5 2010 2010 CD www-nature-com-2208 196 6 ) ) -RRB- www-nature-com-2208 196 7 . . . www-nature-com-2208 197 1 3Benson 3Benson NNP www-nature-com-2208 197 2 , , , www-nature-com-2208 197 3 D. 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NNP www-nature-com-2208 201 11 , , , www-nature-com-2208 201 12 Henrick Henrick NNP www-nature-com-2208 201 13 , , , www-nature-com-2208 201 14 K. K. NNP www-nature-com-2208 201 15 & & CC www-nature-com-2208 201 16 Nakamura Nakamura NNP www-nature-com-2208 201 17 , , , www-nature-com-2208 201 18 H. H. NNP www-nature-com-2208 201 19 Announcing announce VBG www-nature-com-2208 201 20 the the DT www-nature-com-2208 201 21 worldwide worldwide JJ www-nature-com-2208 201 22 Protein Protein NNP www-nature-com-2208 201 23 Data Data NNPS www-nature-com-2208 201 24 Bank Bank NNP www-nature-com-2208 201 25 . . . www-nature-com-2208 202 1 Nat Nat NNP www-nature-com-2208 202 2 . . . www-nature-com-2208 203 1 Struct struct NN www-nature-com-2208 203 2 . . . www-nature-com-2208 204 1 Biol Biol NNP www-nature-com-2208 204 2 . . . www-nature-com-2208 205 1 10 10 CD www-nature-com-2208 205 2 , , , www-nature-com-2208 205 3 980–980 980–980 CD www-nature-com-2208 205 4 ( ( -LRB- www-nature-com-2208 205 5 2003 2003 CD www-nature-com-2208 205 6 ) ) -RRB- www-nature-com-2208 205 7 . . . www-nature-com-2208 206 1 CAS CAS NNP www-nature-com-2208 206 2     _SP www-nature-com-2208 206 3 Article Article NNP www-nature-com-2208 206 4     _SP www-nature-com-2208 206 5 Google Google NNP www-nature-com-2208 206 6 Scholar Scholar NNP www-nature-com-2208 206 7     _SP www-nature-com-2208 206 8 5The 5the CD www-nature-com-2208 206 9 Uniprot Uniprot NNP www-nature-com-2208 206 10 Consortium Consortium NNP www-nature-com-2208 206 11 . . . www-nature-com-2208 207 1 UniProt UniProt NNP www-nature-com-2208 207 2 : : : www-nature-com-2208 207 3 a a DT www-nature-com-2208 207 4 hub hub NN www-nature-com-2208 207 5 for for IN www-nature-com-2208 207 6 protein protein NN www-nature-com-2208 207 7 information information NN www-nature-com-2208 207 8 . . . www-nature-com-2208 208 1 Nucleic Nucleic NNP www-nature-com-2208 208 2 Acids Acids NNPS www-nature-com-2208 208 3 Res Res NNP www-nature-com-2208 208 4 . . . www-nature-com-2208 209 1 43 43 CD www-nature-com-2208 209 2 , , , www-nature-com-2208 209 3 D204–D212 D204–D212 NNP www-nature-com-2208 209 4 ( ( -LRB- www-nature-com-2208 209 5 2015 2015 CD www-nature-com-2208 209 6 ) ) -RRB- www-nature-com-2208 209 7 . . . www-nature-com-2208 210 1 Article Article NNP www-nature-com-2208 210 2     _SP www-nature-com-2208 210 3 Google Google NNP www-nature-com-2208 210 4 Scholar Scholar NNP www-nature-com-2208 210 5     _SP www-nature-com-2208 210 6 6Wenger 6Wenger NNP www-nature-com-2208 210 7 , , , www-nature-com-2208 210 8 M. M. NNP www-nature-com-2208 210 9 et et NNP www-nature-com-2208 210 10 al al NNP www-nature-com-2208 210 11 . . . www-nature-com-2208 211 1 The the DT www-nature-com-2208 211 2 SIMBAD SIMBAD NNP www-nature-com-2208 211 3 astronomical astronomical JJ www-nature-com-2208 211 4 database database NN www-nature-com-2208 211 5 - - : www-nature-com-2208 211 6 The the DT www-nature-com-2208 211 7 CDS CDS NNP www-nature-com-2208 211 8 reference reference NN www-nature-com-2208 211 9 database database NN www-nature-com-2208 211 10 for for IN www-nature-com-2208 211 11 astronomical astronomical JJ www-nature-com-2208 211 12 objects object NNS www-nature-com-2208 211 13 . . . www-nature-com-2208 212 1 Astron Astron NNP www-nature-com-2208 212 2 . . . www-nature-com-2208 213 1 Astrophys Astrophys NNP www-nature-com-2208 213 2 . . . www-nature-com-2208 214 1 Suppl suppl NN www-nature-com-2208 214 2 . . . www-nature-com-2208 215 1 Ser Ser NNP www-nature-com-2208 215 2 . . . www-nature-com-2208 216 1 143 143 CD www-nature-com-2208 216 2 , , , www-nature-com-2208 216 3 9–22 9–22 CD www-nature-com-2208 216 4 ( ( -LRB- www-nature-com-2208 216 5 2000 2000 CD www-nature-com-2208 216 6 ) ) -RRB- www-nature-com-2208 216 7 . . . www-nature-com-2208 217 1 ADS ADS NNP www-nature-com-2208 217 2     _SP www-nature-com-2208 217 3 Article Article NNP www-nature-com-2208 217 4     _SP www-nature-com-2208 217 5 Google Google NNP www-nature-com-2208 217 6 Scholar Scholar NNP www-nature-com-2208 217 7     _SP www-nature-com-2208 217 8 7Crosas 7Crosas NNP www-nature-com-2208 217 9 , , , www-nature-com-2208 217 10 M. M. NNP www-nature-com-2208 217 11 " " `` www-nature-com-2208 217 12 The the DT www-nature-com-2208 217 13 Dataverse Dataverse NNP www-nature-com-2208 217 14 Network Network NNP www-nature-com-2208 217 15 ® ® NNPS www-nature-com-2208 217 16 : : : www-nature-com-2208 217 17 An an DT www-nature-com-2208 217 18 Open open JJ www-nature-com-2208 217 19 - - HYPH www-nature-com-2208 217 20 Source source NN www-nature-com-2208 217 21 Application application NN www-nature-com-2208 217 22 for for IN www-nature-com-2208 217 23 Sharing sharing NN www-nature-com-2208 217 24 , , , www-nature-com-2208 217 25 Discovering Discovering NNP www-nature-com-2208 217 26 and and CC www-nature-com-2208 217 27 Preserving Preserving NNP www-nature-com-2208 217 28 Data Data NNPS www-nature-com-2208 217 29 " " '' www-nature-com-2208 217 30 . . . www-nature-com-2208 218 1 D D NNP www-nature-com-2208 218 2 - - HYPH www-nature-com-2208 218 3 Lib Lib NNP www-nature-com-2208 218 4 Mag Mag NNP www-nature-com-2208 218 5 17 17 CD www-nature-com-2208 218 6 ( ( -LRB- www-nature-com-2208 218 7 1 1 CD www-nature-com-2208 218 8 ) ) -RRB- www-nature-com-2208 218 9 , , , www-nature-com-2208 218 10 p2 p2 NNP www-nature-com-2208 218 11 ( ( -LRB- www-nature-com-2208 218 12 2011 2011 CD www-nature-com-2208 218 13 ) ) -RRB- www-nature-com-2208 218 14 . . . www-nature-com-2208 219 1 Google Google NNP www-nature-com-2208 219 2 Scholar Scholar NNP www-nature-com-2208 219 3     _SP www-nature-com-2208 219 4 8White 8White NNP www-nature-com-2208 219 5 , , , www-nature-com-2208 219 6 H. H. NNP www-nature-com-2208 219 7 C. C. NNP www-nature-com-2208 219 8 , , , www-nature-com-2208 219 9 Carrier Carrier NNP www-nature-com-2208 219 10 , , , www-nature-com-2208 219 11 S. S. NNP www-nature-com-2208 219 12 , , , www-nature-com-2208 219 13 Thompson Thompson NNP www-nature-com-2208 219 14 , , , www-nature-com-2208 219 15 A. A. NNP www-nature-com-2208 219 16 , , , www-nature-com-2208 219 17 Greenberg Greenberg NNP www-nature-com-2208 219 18 , , , www-nature-com-2208 219 19 J. J. NNP www-nature-com-2208 220 1 & & CC www-nature-com-2208 220 2 Scherle Scherle NNP www-nature-com-2208 220 3 , , , www-nature-com-2208 220 4 R. R. NNP www-nature-com-2208 220 5 The The NNP www-nature-com-2208 220 6 Dryad Dryad NNP www-nature-com-2208 220 7 data data NN www-nature-com-2208 220 8 repository repository NN www-nature-com-2208 220 9 : : : www-nature-com-2208 220 10 A a DT www-nature-com-2208 220 11 Singapore Singapore NNP www-nature-com-2208 220 12 framework framework NN www-nature-com-2208 220 13 metadata metadata NN www-nature-com-2208 220 14 architecture architecture NN www-nature-com-2208 220 15 in in IN www-nature-com-2208 220 16 a a DT www-nature-com-2208 220 17 DSpace DSpace NNP www-nature-com-2208 220 18 environment environment NN www-nature-com-2208 220 19 . . . www-nature-com-2208 221 1 Univ Univ NNP www-nature-com-2208 221 2 . . . www-nature-com-2208 222 1 Göttingen Göttingen NNP www-nature-com-2208 222 2 , , , www-nature-com-2208 222 3 p157 p157 NNP www-nature-com-2208 222 4 ( ( -LRB- www-nature-com-2208 222 5 2008 2008 CD www-nature-com-2208 222 6 ) ) -RRB- www-nature-com-2208 222 7 . . . www-nature-com-2208 223 1 9Lecarpentier 9Lecarpentier NNP www-nature-com-2208 223 2 , , , www-nature-com-2208 223 3 D. D. NNP www-nature-com-2208 223 4 et et NNP www-nature-com-2208 223 5 al al NNP www-nature-com-2208 223 6 . . . www-nature-com-2208 224 1 EUDAT EUDAT NNP www-nature-com-2208 224 2 : : : www-nature-com-2208 224 3 A a DT www-nature-com-2208 224 4 New New NNP www-nature-com-2208 224 5 Cross Cross NNP www-nature-com-2208 224 6 - - HYPH www-nature-com-2208 224 7 Disciplinary Disciplinary NNP www-nature-com-2208 224 8 Data Data NNP www-nature-com-2208 224 9 Infrastructure Infrastructure NNP www-nature-com-2208 224 10 for for IN www-nature-com-2208 224 11 Science Science NNP www-nature-com-2208 224 12 . . . www-nature-com-2208 225 1 Int Int NNP www-nature-com-2208 225 2 . . . www-nature-com-2208 226 1 J. J. NNP www-nature-com-2208 226 2 Digit Digit NNP www-nature-com-2208 226 3 . . . www-nature-com-2208 227 1 Curation curation NN www-nature-com-2208 227 2 8 8 CD www-nature-com-2208 227 3 , , , www-nature-com-2208 227 4 279–287 279–287 CD www-nature-com-2208 227 5 ( ( -LRB- www-nature-com-2208 227 6 2013 2013 CD www-nature-com-2208 227 7 ) ) -RRB- www-nature-com-2208 227 8 . . . www-nature-com-2208 228 1 Article Article NNP www-nature-com-2208 228 2     _SP www-nature-com-2208 228 3 Google Google NNP www-nature-com-2208 228 4 Scholar Scholar NNP www-nature-com-2208 228 5     _SP www-nature-com-2208 228 6 10Martone 10Martone NNP www-nature-com-2208 228 7 , , , www-nature-com-2208 228 8 M. M. NNP www-nature-com-2208 228 9 E. E. NNP www-nature-com-2208 228 10 FORCE11 FORCE11 NNP www-nature-com-2208 228 11 : : : www-nature-com-2208 228 12 Building build VBG www-nature-com-2208 228 13 the the DT www-nature-com-2208 228 14 Future Future NNP www-nature-com-2208 228 15 for for IN www-nature-com-2208 228 16 Research Research NNP www-nature-com-2208 228 17 Communications Communications NNPS www-nature-com-2208 228 18 and and CC www-nature-com-2208 228 19 e e NNP www-nature-com-2208 228 20 - - NN www-nature-com-2208 228 21 Scholarship scholarship NN www-nature-com-2208 228 22 . . . www-nature-com-2208 229 1 Bioscience Bioscience NNP www-nature-com-2208 229 2 65 65 CD www-nature-com-2208 229 3 , , , www-nature-com-2208 229 4 635 635 CD www-nature-com-2208 229 5 ( ( -LRB- www-nature-com-2208 229 6 2015 2015 CD www-nature-com-2208 229 7 ) ) -RRB- www-nature-com-2208 229 8 . . . www-nature-com-2208 230 1 Article Article NNP www-nature-com-2208 230 2     _SP www-nature-com-2208 230 3 Google Google NNP www-nature-com-2208 230 4 Scholar Scholar NNP www-nature-com-2208 230 5     _SP www-nature-com-2208 230 6 11White 11White NNP www-nature-com-2208 230 7 , , , www-nature-com-2208 230 8 E. E. NNP www-nature-com-2208 230 9 et et NNP www-nature-com-2208 230 10 al al NNP www-nature-com-2208 230 11 . . . www-nature-com-2208 231 1 Nine nine CD www-nature-com-2208 231 2 simple simple JJ www-nature-com-2208 231 3 ways way NNS www-nature-com-2208 231 4 to to TO www-nature-com-2208 231 5 make make VB www-nature-com-2208 231 6 it -PRON- PRP www-nature-com-2208 231 7 easier easy JJR www-nature-com-2208 231 8 to to IN www-nature-com-2208 231 9 ( ( -LRB- www-nature-com-2208 231 10 re)use re)use VB www-nature-com-2208 231 11 your -PRON- PRP$ www-nature-com-2208 231 12 data datum NNS www-nature-com-2208 231 13 . . . www-nature-com-2208 232 1 Ideas Ideas NNP www-nature-com-2208 232 2 Ecol Ecol NNP www-nature-com-2208 232 3 . . . www-nature-com-2208 233 1 Evol Evol NNP www-nature-com-2208 233 2 . . . www-nature-com-2208 234 1 6 6 CD www-nature-com-2208 234 2 ( ( -LRB- www-nature-com-2208 234 3 2013 2013 CD www-nature-com-2208 234 4 ) ) -RRB- www-nature-com-2208 234 5 . . . www-nature-com-2208 235 1 12Sandve 12sandve CD www-nature-com-2208 235 2 , , , www-nature-com-2208 235 3 G. G. NNP www-nature-com-2208 235 4 K. K. NNP www-nature-com-2208 235 5 , , , www-nature-com-2208 235 6 Nekrutenko Nekrutenko NNP www-nature-com-2208 235 7 , , , www-nature-com-2208 235 8 A. A. NNP www-nature-com-2208 235 9 , , , www-nature-com-2208 235 10 Taylor Taylor NNP www-nature-com-2208 235 11 , , , www-nature-com-2208 235 12 J. J. NNP www-nature-com-2208 236 1 & & CC www-nature-com-2208 236 2 Hovig Hovig NNP www-nature-com-2208 236 3 , , , www-nature-com-2208 236 4 E. E. NNP www-nature-com-2208 236 5 Ten Ten NNP www-nature-com-2208 236 6 Simple Simple NNP www-nature-com-2208 236 7 Rules Rules NNPS www-nature-com-2208 236 8 for for IN www-nature-com-2208 236 9 Reproducible Reproducible NNP www-nature-com-2208 236 10 Computational Computational NNP www-nature-com-2208 236 11 Research Research NNP www-nature-com-2208 236 12 . . . www-nature-com-2208 237 1 PLoS PLoS : www-nature-com-2208 237 2 Comput Comput NNP www-nature-com-2208 237 3 . . . www-nature-com-2208 238 1 Biol Biol NNP www-nature-com-2208 238 2 . . . www-nature-com-2208 239 1 9 9 CD www-nature-com-2208 239 2 , , , www-nature-com-2208 239 3 e1003285 e1003285 NNP www-nature-com-2208 239 4 ( ( -LRB- www-nature-com-2208 239 5 2013 2013 CD www-nature-com-2208 239 6 ) ) -RRB- www-nature-com-2208 239 7 . . . www-nature-com-2208 240 1 ADS ADS NNP www-nature-com-2208 240 2     _SP www-nature-com-2208 240 3 Article Article NNP www-nature-com-2208 240 4     _SP www-nature-com-2208 240 5 Google Google NNP www-nature-com-2208 240 6 Scholar Scholar NNP www-nature-com-2208 240 7     _SP www-nature-com-2208 240 8 13Altman 13Altman NNP www-nature-com-2208 240 9 , , , www-nature-com-2208 240 10 M. M. NNP www-nature-com-2208 240 11 & & CC www-nature-com-2208 240 12 King King NNP www-nature-com-2208 240 13 , , , www-nature-com-2208 240 14 G. G. NNP www-nature-com-2208 240 15 in in IN www-nature-com-2208 240 16 D D NNP www-nature-com-2208 240 17 - - HYPH www-nature-com-2208 240 18 Lib Lib NNP www-nature-com-2208 240 19 Magazine Magazine NNP www-nature-com-2208 240 20 13 13 CD www-nature-com-2208 240 21 , , , www-nature-com-2208 240 22 no no UH www-nature-com-2208 240 23 . . . www-nature-com-2208 241 1 3/4 3/4 CD www-nature-com-2208 241 2 ( ( -LRB- www-nature-com-2208 241 3 2007 2007 CD www-nature-com-2208 241 4 ) ) -RRB- www-nature-com-2208 241 5 . . . www-nature-com-2208 242 1 Google Google NNP www-nature-com-2208 242 2 Scholar Scholar NNP www-nature-com-2208 242 3     _SP www-nature-com-2208 242 4 14Wolstencroft 14Wolstencroft NNP www-nature-com-2208 242 5 , , , www-nature-com-2208 242 6 K. K. NNP www-nature-com-2208 242 7 et et NNP www-nature-com-2208 242 8 al al NNP www-nature-com-2208 242 9 . . . www-nature-com-2208 243 1 SEEK SEEK NNP www-nature-com-2208 243 2 : : : www-nature-com-2208 243 3 a a DT www-nature-com-2208 243 4 systems system NNS www-nature-com-2208 243 5 biology biology NN www-nature-com-2208 243 6 data datum NNS www-nature-com-2208 243 7 and and CC www-nature-com-2208 243 8 model model NN www-nature-com-2208 243 9 management management NN www-nature-com-2208 243 10 platform platform NN www-nature-com-2208 243 11 . . . www-nature-com-2208 244 1 BMC BMC NNP www-nature-com-2208 244 2 Syst Syst NNP www-nature-com-2208 244 3 . . . www-nature-com-2208 245 1 Biol Biol NNP www-nature-com-2208 245 2 . . . www-nature-com-2208 246 1 9 9 CD www-nature-com-2208 246 2 , , , www-nature-com-2208 246 3 33 33 CD www-nature-com-2208 246 4 ( ( -LRB- www-nature-com-2208 246 5 2015 2015 CD www-nature-com-2208 246 6 ) ) -RRB- www-nature-com-2208 246 7 . . . www-nature-com-2208 247 1 Article Article NNP www-nature-com-2208 247 2     _SP www-nature-com-2208 247 3 Google Google NNP www-nature-com-2208 247 4 Scholar Scholar NNP www-nature-com-2208 247 5     _SP www-nature-com-2208 247 6 15Bauch 15Bauch NNP www-nature-com-2208 247 7 , , , www-nature-com-2208 247 8 A. A. NNP www-nature-com-2208 247 9 et et FW www-nature-com-2208 247 10 al al NNP www-nature-com-2208 247 11 . . . www-nature-com-2208 248 1 openBIS openbis IN www-nature-com-2208 248 2 : : : www-nature-com-2208 248 3 a a DT www-nature-com-2208 248 4 flexible flexible JJ www-nature-com-2208 248 5 framework framework NN www-nature-com-2208 248 6 for for IN www-nature-com-2208 248 7 managing manage VBG www-nature-com-2208 248 8 and and CC www-nature-com-2208 248 9 analyzing analyze VBG www-nature-com-2208 248 10 complex complex JJ www-nature-com-2208 248 11 data datum NNS www-nature-com-2208 248 12 in in IN www-nature-com-2208 248 13 biology biology NN www-nature-com-2208 248 14 research research NN www-nature-com-2208 248 15 . . . www-nature-com-2208 249 1 BMC BMC NNP www-nature-com-2208 249 2 Bioinformatics Bioinformatics NNP www-nature-com-2208 249 3 12 12 CD www-nature-com-2208 249 4 , , , www-nature-com-2208 249 5 468 468 CD www-nature-com-2208 249 6 ( ( -LRB- www-nature-com-2208 249 7 2011 2011 CD www-nature-com-2208 249 8 ) ) -RRB- www-nature-com-2208 249 9 . . . www-nature-com-2208 250 1 Article Article NNP www-nature-com-2208 250 2     _SP www-nature-com-2208 250 3 Google Google NNP www-nature-com-2208 250 4 Scholar Scholar NNP www-nature-com-2208 250 5     _SP www-nature-com-2208 250 6 16Sansone 16Sansone NNP www-nature-com-2208 250 7 , , , www-nature-com-2208 250 8 S.-A. s.-a. XX www-nature-com-2208 251 1 et et NNP www-nature-com-2208 251 2 al al NNP www-nature-com-2208 251 3 . . . www-nature-com-2208 252 1 Toward toward IN www-nature-com-2208 252 2 interoperable interoperable JJ www-nature-com-2208 252 3 bioscience bioscience NN www-nature-com-2208 252 4 data datum NNS www-nature-com-2208 252 5 . . . www-nature-com-2208 253 1 Nat Nat NNP www-nature-com-2208 253 2 . . . www-nature-com-2208 254 1 Genet Genet NNP www-nature-com-2208 254 2 . . . www-nature-com-2208 255 1 44 44 CD www-nature-com-2208 255 2 , , , www-nature-com-2208 255 3 121–126 121–126 CD www-nature-com-2208 255 4 ( ( -LRB- www-nature-com-2208 255 5 2012 2012 CD www-nature-com-2208 255 6 ) ) -RRB- www-nature-com-2208 255 7 . . . www-nature-com-2208 256 1 CAS CAS NNP www-nature-com-2208 256 2     _SP www-nature-com-2208 256 3 Article Article NNP www-nature-com-2208 256 4     _SP www-nature-com-2208 256 5 Google Google NNP www-nature-com-2208 256 6 Scholar Scholar NNP www-nature-com-2208 256 7     _SP www-nature-com-2208 256 8 17González 17González NNP www-nature-com-2208 256 9 - - HYPH www-nature-com-2208 256 10 Beltrán Beltrán NNP www-nature-com-2208 256 11 , , , www-nature-com-2208 256 12 A. a. NN www-nature-com-2208 256 13 , , , www-nature-com-2208 256 14 Maguire Maguire NNP www-nature-com-2208 256 15 , , , www-nature-com-2208 256 16 E. E. NNP www-nature-com-2208 256 17 , , , www-nature-com-2208 256 18 Sansone Sansone NNP www-nature-com-2208 256 19 , , , www-nature-com-2208 256 20 S.-A. s.-a. XX www-nature-com-2208 257 1 & & CC www-nature-com-2208 257 2 Rocca Rocca NNP www-nature-com-2208 257 3 - - HYPH www-nature-com-2208 257 4 Serra Serra NNP www-nature-com-2208 257 5 , , , www-nature-com-2208 257 6 P. P. NNP www-nature-com-2208 257 7 linkedISA linkedISA NNP www-nature-com-2208 257 8 : : : www-nature-com-2208 257 9 semantic semantic JJ www-nature-com-2208 257 10 representation representation NN www-nature-com-2208 257 11 of of IN www-nature-com-2208 257 12 ISA ISA NNP www-nature-com-2208 257 13 - - HYPH www-nature-com-2208 257 14 Tab Tab NNP www-nature-com-2208 257 15 experimental experimental JJ www-nature-com-2208 257 16 metadata metadata NN www-nature-com-2208 257 17 . . . www-nature-com-2208 258 1 BMC BMC NNP www-nature-com-2208 258 2 Bioinformatics Bioinformatics NNP www-nature-com-2208 258 3 15 15 CD www-nature-com-2208 258 4 , , , www-nature-com-2208 258 5 S4 S4 NNP www-nature-com-2208 258 6 ( ( -LRB- www-nature-com-2208 258 7 2014 2014 CD www-nature-com-2208 258 8 ) ) -RRB- www-nature-com-2208 258 9 . . . www-nature-com-2208 259 1 Article Article NNP www-nature-com-2208 259 2     _SP www-nature-com-2208 259 3 Google Google NNP www-nature-com-2208 259 4 Scholar Scholar NNP www-nature-com-2208 259 5     _SP www-nature-com-2208 259 6 18González 18González NNP www-nature-com-2208 259 7 - - HYPH www-nature-com-2208 259 8 Beltrán Beltrán NNP www-nature-com-2208 259 9 , , , www-nature-com-2208 259 10 A. A. NNP www-nature-com-2208 259 11 et et FW www-nature-com-2208 259 12 al al NNP www-nature-com-2208 259 13 . . . www-nature-com-2208 260 1 From from IN www-nature-com-2208 260 2 Peer Peer NNP www-nature-com-2208 260 3 - - HYPH www-nature-com-2208 260 4 Reviewed review VBN www-nature-com-2208 260 5 to to IN www-nature-com-2208 260 6 Peer Peer NNP www-nature-com-2208 260 7 - - HYPH www-nature-com-2208 260 8 Reproduced reproduce VBN www-nature-com-2208 260 9 in in IN www-nature-com-2208 260 10 Scholarly Scholarly NNP www-nature-com-2208 260 11 Publishing Publishing NNP www-nature-com-2208 260 12 : : : www-nature-com-2208 260 13 The the DT www-nature-com-2208 260 14 Complementary Complementary NNP www-nature-com-2208 260 15 Roles Roles NNPS www-nature-com-2208 260 16 of of IN www-nature-com-2208 260 17 Data Data NNPS www-nature-com-2208 260 18 Models Models NNPS www-nature-com-2208 260 19 and and CC www-nature-com-2208 260 20 Workflows Workflows NNPS www-nature-com-2208 260 21 in in IN www-nature-com-2208 260 22 Bioinformatics Bioinformatics NNP www-nature-com-2208 260 23 . . . www-nature-com-2208 261 1 PLoS PLoS NNP www-nature-com-2208 261 2 ONE one CD www-nature-com-2208 261 3 10 10 CD www-nature-com-2208 261 4 , , , www-nature-com-2208 261 5 e0127612 e0127612 NNP www-nature-com-2208 261 6 ( ( -LRB- www-nature-com-2208 261 7 2015 2015 CD www-nature-com-2208 261 8 ) ) -RRB- www-nature-com-2208 261 9 . . . www-nature-com-2208 262 1 Article Article NNP www-nature-com-2208 262 2     _SP www-nature-com-2208 262 3 Google Google NNP www-nature-com-2208 262 4 Scholar Scholar NNP www-nature-com-2208 262 5     _SP www-nature-com-2208 262 6 19Harland 19Harland NNP www-nature-com-2208 262 7 , , , www-nature-com-2208 262 8 L. L. NNP www-nature-com-2208 262 9 Open open JJ www-nature-com-2208 262 10 PHACTS PHACTS NNP www-nature-com-2208 262 11 : : : www-nature-com-2208 262 12 A a DT www-nature-com-2208 262 13 Semantic semantic JJ www-nature-com-2208 262 14 Knowledge knowledge NN www-nature-com-2208 262 15 Infrastructure infrastructure NN www-nature-com-2208 262 16 for for IN www-nature-com-2208 262 17 Public Public NNP www-nature-com-2208 262 18 and and CC www-nature-com-2208 262 19 Commercial Commercial NNP www-nature-com-2208 262 20 Drug Drug NNP www-nature-com-2208 262 21 Discovery Discovery NNP www-nature-com-2208 262 22 Research Research NNP www-nature-com-2208 262 23 . . . www-nature-com-2208 263 1 Knowl Knowl NNP www-nature-com-2208 263 2 . . . www-nature-com-2208 264 1 Eng Eng NNP www-nature-com-2208 264 2 . . . www-nature-com-2208 265 1 Knowl Knowl NNP www-nature-com-2208 265 2 . . . www-nature-com-2208 266 1 Manag Manag NNP www-nature-com-2208 266 2 . . . www-nature-com-2208 267 1 Lect Lect NNP www-nature-com-2208 267 2 . . . www-nature-com-2208 268 1 Notes Notes NNPS www-nature-com-2208 268 2 Comput Comput NNP www-nature-com-2208 268 3 . . . www-nature-com-2208 269 1 Sci Sci NNP www-nature-com-2208 269 2 . . . www-nature-com-2208 270 1 7603/2012 7603/2012 NNP www-nature-com-2208 270 2 , , , www-nature-com-2208 270 3 1–7 1–7 CD www-nature-com-2208 270 4 ( ( -LRB- www-nature-com-2208 270 5 2012 2012 CD www-nature-com-2208 270 6 ) ) -RRB- www-nature-com-2208 270 7 . . . www-nature-com-2208 271 1 Google Google NNP www-nature-com-2208 271 2 Scholar Scholar NNP www-nature-com-2208 271 3     _SP www-nature-com-2208 271 4 20Groth 20Groth NNP www-nature-com-2208 271 5 , , , www-nature-com-2208 271 6 P. 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NNP www-nature-com-2208 271 7 et et NNP www-nature-com-2208 271 8 al al NNP www-nature-com-2208 271 9 . . . www-nature-com-2208 272 1 API api NN www-nature-com-2208 272 2 - - HYPH www-nature-com-2208 272 3 centric centric JJ www-nature-com-2208 272 4 Linked Linked NNP www-nature-com-2208 272 5 Data Data NNP www-nature-com-2208 272 6 integration integration NN www-nature-com-2208 272 7 : : : www-nature-com-2208 272 8 The the DT www-nature-com-2208 272 9 Open open JJ www-nature-com-2208 272 10 PHACTS PHACTS NNP www-nature-com-2208 272 11 Discovery Discovery NNP www-nature-com-2208 272 12 Platform Platform NNP www-nature-com-2208 272 13 case case NN www-nature-com-2208 272 14 study study NN www-nature-com-2208 272 15 . . . www-nature-com-2208 273 1 Web Web NNP www-nature-com-2208 273 2 Semant Semant NNP www-nature-com-2208 273 3 . . . www-nature-com-2208 274 1 Sci Sci NNP www-nature-com-2208 274 2 . . . www-nature-com-2208 275 1 Serv Serv NNP www-nature-com-2208 275 2 . . . www-nature-com-2208 276 1 Agents agent NNS www-nature-com-2208 276 2 World World NNP www-nature-com-2208 276 3 Wide wide JJ www-nature-com-2208 276 4 Web web NN www-nature-com-2208 276 5 29 29 CD www-nature-com-2208 276 6 , , , www-nature-com-2208 276 7 12–18 12–18 CD www-nature-com-2208 276 8 ( ( -LRB- www-nature-com-2208 276 9 2014 2014 CD www-nature-com-2208 276 10 ) ) -RRB- www-nature-com-2208 276 11 . . . www-nature-com-2208 277 1 Article Article NNP www-nature-com-2208 277 2     _SP www-nature-com-2208 277 3 Google Google NNP www-nature-com-2208 277 4 Scholar Scholar NNP www-nature-com-2208 277 5     _SP www-nature-com-2208 277 6 21Berman 21Berman NNP www-nature-com-2208 277 7 , , , www-nature-com-2208 277 8 H. 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NNP www-nature-com-2208 277 10 et et NNP www-nature-com-2208 277 11 al al NNP www-nature-com-2208 277 12 . . . www-nature-com-2208 278 1 The the DT www-nature-com-2208 278 2 Protein Protein NNP www-nature-com-2208 278 3 Data Data NNPS www-nature-com-2208 278 4 Bank Bank NNP www-nature-com-2208 278 5 . . . www-nature-com-2208 279 1 Nucleic Nucleic NNP www-nature-com-2208 279 2 Acids Acids NNPS www-nature-com-2208 279 3 Res Res NNP www-nature-com-2208 279 4 . . . www-nature-com-2208 280 1 28 28 CD www-nature-com-2208 280 2 , , , www-nature-com-2208 280 3 235–242 235–242 CD www-nature-com-2208 280 4 ( ( -LRB- www-nature-com-2208 280 5 2000 2000 CD www-nature-com-2208 280 6 ) ) -RRB- www-nature-com-2208 280 7 . . . www-nature-com-2208 281 1 ADS ADS NNP www-nature-com-2208 281 2     _SP www-nature-com-2208 281 3 CAS CAS NNP www-nature-com-2208 281 4     _SP www-nature-com-2208 281 5 Article Article NNP www-nature-com-2208 281 6     _SP www-nature-com-2208 281 7 Google Google NNP www-nature-com-2208 281 8 Scholar Scholar NNP www-nature-com-2208 281 9     _SP www-nature-com-2208 281 10 22Bourne 22Bourne NNP www-nature-com-2208 281 11 , , , www-nature-com-2208 281 12 P. P. NNP www-nature-com-2208 281 13 E. E. NNP www-nature-com-2208 281 14 , , , www-nature-com-2208 281 15 Berman Berman NNP www-nature-com-2208 281 16 , , , www-nature-com-2208 281 17 H. H. NNP www-nature-com-2208 281 18 M. M. NNP www-nature-com-2208 281 19 , , , www-nature-com-2208 281 20 Watenpaugh Watenpaugh NNP www-nature-com-2208 281 21 , , , www-nature-com-2208 281 22 K. K. NNP www-nature-com-2208 281 23 , , , www-nature-com-2208 281 24 Westbrook Westbrook NNP www-nature-com-2208 281 25 , , , www-nature-com-2208 281 26 J. J. NNP www-nature-com-2208 281 27 D. D. NNP www-nature-com-2208 281 28 & & CC www-nature-com-2208 281 29 Fitzgerald Fitzgerald NNP www-nature-com-2208 281 30 , , , www-nature-com-2208 281 31 P. P. NNP www-nature-com-2208 281 32 M. M. NNP www-nature-com-2208 281 33 D. D. NNP www-nature-com-2208 281 34 The The NNP www-nature-com-2208 281 35 macromolecular macromolecular JJ www-nature-com-2208 281 36 crystallographic crystallographic JJ www-nature-com-2208 281 37 information information NN www-nature-com-2208 281 38 file file NN www-nature-com-2208 281 39 ( ( -LRB- www-nature-com-2208 281 40 mmCIF mmCIF NNP www-nature-com-2208 281 41 ) ) -RRB- www-nature-com-2208 281 42 . . . www-nature-com-2208 282 1 Meth Meth NNP www-nature-com-2208 282 2 . . . www-nature-com-2208 283 1 Enzym enzym NN www-nature-com-2208 283 2 277 277 CD www-nature-com-2208 283 3 , , , www-nature-com-2208 283 4 571–590 571–590 CD www-nature-com-2208 283 5 ( ( -LRB- www-nature-com-2208 283 6 1997 1997 CD www-nature-com-2208 283 7 ) ) -RRB- www-nature-com-2208 283 8 . . . www-nature-com-2208 284 1 CAS CAS NNP www-nature-com-2208 284 2     _SP www-nature-com-2208 284 3 Article Article NNP www-nature-com-2208 284 4     _SP www-nature-com-2208 284 5 Google Google NNP www-nature-com-2208 284 6 Scholar Scholar NNP www-nature-com-2208 284 7     _SP www-nature-com-2208 284 8 23Rose 23Rose NNP www-nature-com-2208 284 9 , , , www-nature-com-2208 284 10 P. 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NNP www-nature-com-2208 284 12 et et NNP www-nature-com-2208 284 13 al al NNP www-nature-com-2208 284 14 . . . www-nature-com-2208 285 1 The the DT www-nature-com-2208 285 2 RCSB RCSB NNP www-nature-com-2208 285 3 Protein Protein NNP www-nature-com-2208 285 4 Data Data NNPS www-nature-com-2208 285 5 Bank Bank NNP www-nature-com-2208 285 6 : : : www-nature-com-2208 285 7 views view NNS www-nature-com-2208 285 8 of of IN www-nature-com-2208 285 9 structural structural JJ www-nature-com-2208 285 10 biology biology NN www-nature-com-2208 285 11 for for IN www-nature-com-2208 285 12 basic basic JJ www-nature-com-2208 285 13 and and CC www-nature-com-2208 285 14 applied applied JJ www-nature-com-2208 285 15 research research NN www-nature-com-2208 285 16 and and CC www-nature-com-2208 285 17 education education NN www-nature-com-2208 285 18 . . . www-nature-com-2208 286 1 Nucleic Nucleic NNP www-nature-com-2208 286 2 Acids Acids NNPS www-nature-com-2208 286 3 Res Res NNP www-nature-com-2208 286 4 . . . www-nature-com-2208 287 1 43 43 CD www-nature-com-2208 287 2 , , , www-nature-com-2208 287 3 D345–D356 D345–D356 NNP www-nature-com-2208 287 4 ( ( -LRB- www-nature-com-2208 287 5 2015 2015 CD www-nature-com-2208 287 6 ) ) -RRB- www-nature-com-2208 287 7 . . . www-nature-com-2208 288 1 CAS CAS NNP www-nature-com-2208 288 2     _SP www-nature-com-2208 288 3 Article Article NNP www-nature-com-2208 288 4     _SP www-nature-com-2208 288 5 Google Google NNP www-nature-com-2208 288 6 Scholar Scholar NNP www-nature-com-2208 288 7     _SP www-nature-com-2208 288 8 24Kinjo 24Kinjo NNP www-nature-com-2208 288 9 , , , www-nature-com-2208 288 10 A. 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NNP www-nature-com-2208 288 12 et et NNP www-nature-com-2208 288 13 al al NNP www-nature-com-2208 288 14 . . . www-nature-com-2208 289 1 Protein Protein NNP www-nature-com-2208 289 2 Data Data NNPS www-nature-com-2208 289 3 Bank Bank NNP www-nature-com-2208 289 4 Japan Japan NNP www-nature-com-2208 289 5 ( ( -LRB- www-nature-com-2208 289 6 PDBj PDBj NNP www-nature-com-2208 289 7 ) ) -RRB- www-nature-com-2208 289 8 : : : www-nature-com-2208 289 9 maintaining maintain VBG www-nature-com-2208 289 10 a a DT www-nature-com-2208 289 11 structural structural JJ www-nature-com-2208 289 12 data data NN www-nature-com-2208 289 13 archive archive NN www-nature-com-2208 289 14 and and CC www-nature-com-2208 289 15 resource resource NN www-nature-com-2208 289 16 description description NN www-nature-com-2208 289 17 framework framework NN www-nature-com-2208 289 18 format format NN www-nature-com-2208 289 19 . . . www-nature-com-2208 290 1 Nucleic Nucleic NNP www-nature-com-2208 290 2 Acids Acids NNPS www-nature-com-2208 290 3 Res Res NNP www-nature-com-2208 290 4 . . . www-nature-com-2208 291 1 40 40 CD www-nature-com-2208 291 2 , , , www-nature-com-2208 291 3 D453–D460 D453–D460 NNP www-nature-com-2208 291 4 ( ( -LRB- www-nature-com-2208 291 5 2012 2012 CD www-nature-com-2208 291 6 ) ) -RRB- www-nature-com-2208 291 7 . . . www-nature-com-2208 292 1 CAS CAS NNP www-nature-com-2208 292 2     _SP www-nature-com-2208 292 3 Article Article NNP www-nature-com-2208 292 4     _SP www-nature-com-2208 292 5 Google Google NNP www-nature-com-2208 292 6 Scholar Scholar NNP www-nature-com-2208 292 7     _SP www-nature-com-2208 292 8 25Gutmanas 25Gutmanas NNP www-nature-com-2208 292 9 , , , www-nature-com-2208 292 10 A. 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NNP www-nature-com-2208 292 11 et et FW www-nature-com-2208 292 12 al al NNP www-nature-com-2208 292 13 . . . www-nature-com-2208 293 1 PDBe PDBe NNS www-nature-com-2208 293 2 : : : www-nature-com-2208 293 3 Protein Protein NNP www-nature-com-2208 293 4 Data Data NNPS www-nature-com-2208 293 5 Bank Bank NNP www-nature-com-2208 293 6 in in IN www-nature-com-2208 293 7 Europe Europe NNP www-nature-com-2208 293 8 . . . www-nature-com-2208 294 1 Nucleic Nucleic NNP www-nature-com-2208 294 2 Acids Acids NNPS www-nature-com-2208 294 3 Res Res NNP www-nature-com-2208 294 4 . . . www-nature-com-2208 295 1 42 42 CD www-nature-com-2208 295 2 , , , www-nature-com-2208 295 3 D285–D291 D285–D291 NNP www-nature-com-2208 295 4 ( ( -LRB- www-nature-com-2208 295 5 2014 2014 CD www-nature-com-2208 295 6 ) ) -RRB- www-nature-com-2208 295 7 . . . www-nature-com-2208 296 1 CAS CAS NNP www-nature-com-2208 296 2     _SP www-nature-com-2208 296 3 Article Article NNP www-nature-com-2208 296 4     _SP www-nature-com-2208 296 5 Google Google NNP www-nature-com-2208 296 6 Scholar Scholar NNP www-nature-com-2208 296 7     _SP www-nature-com-2208 296 8 26UniProt 26uniprot CD www-nature-com-2208 296 9 Consortium Consortium NNP www-nature-com-2208 296 10 . . . www-nature-com-2208 297 1 UniProt UniProt NNP www-nature-com-2208 297 2 : : : www-nature-com-2208 297 3 a a DT www-nature-com-2208 297 4 hub hub NN www-nature-com-2208 297 5 for for IN www-nature-com-2208 297 6 protein protein NN www-nature-com-2208 297 7 information information NN www-nature-com-2208 297 8 . . . www-nature-com-2208 298 1 Nucleic Nucleic NNP www-nature-com-2208 298 2 Acids Acids NNPS www-nature-com-2208 298 3 Res Res NNP www-nature-com-2208 298 4 . . . www-nature-com-2208 299 1 43 43 CD www-nature-com-2208 299 2 , , , www-nature-com-2208 299 3 D204–D212 D204–D212 NNP www-nature-com-2208 299 4 ( ( -LRB- www-nature-com-2208 299 5 2015 2015 CD www-nature-com-2208 299 6 ) ) -RRB- www-nature-com-2208 299 7 . . . www-nature-com-2208 300 1 Article Article NNP www-nature-com-2208 300 2     _SP www-nature-com-2208 300 3 Google Google NNP www-nature-com-2208 300 4 Scholar Scholar NNP www-nature-com-2208 300 5     _SP www-nature-com-2208 300 6 27Starr 27Starr NNP www-nature-com-2208 300 7 , , , www-nature-com-2208 300 8 J. J. NNP www-nature-com-2208 300 9 et et NNP www-nature-com-2208 300 10 al al NNP www-nature-com-2208 300 11 . . . www-nature-com-2208 301 1 Achieving achieve VBG www-nature-com-2208 301 2 human human NN www-nature-com-2208 301 3 and and CC www-nature-com-2208 301 4 machine machine NN www-nature-com-2208 301 5 accessibility accessibility NN www-nature-com-2208 301 6 of of IN www-nature-com-2208 301 7 cited cite VBN www-nature-com-2208 301 8 data datum NNS www-nature-com-2208 301 9 in in IN www-nature-com-2208 301 10 scholarly scholarly JJ www-nature-com-2208 301 11 publications publication NNS www-nature-com-2208 301 12 . . . www-nature-com-2208 302 1 PeerJ PeerJ NNP www-nature-com-2208 302 2 Comput comput NN www-nature-com-2208 302 3 . . . www-nature-com-2208 303 1 Sci Sci NNP www-nature-com-2208 303 2 . . . www-nature-com-2208 304 1 1 1 CD www-nature-com-2208 304 2 , , , www-nature-com-2208 304 3 e1 e1 NNP www-nature-com-2208 304 4 ( ( -LRB- www-nature-com-2208 304 5 2015 2015 CD www-nature-com-2208 304 6 ) ) -RRB- www-nature-com-2208 304 7 . . . www-nature-com-2208 305 1 Article Article NNP www-nature-com-2208 305 2     _SP www-nature-com-2208 305 3 Google Google NNP www-nature-com-2208 305 4 Scholar Scholar NNP www-nature-com-2208 305 5     _SP www-nature-com-2208 305 6 28Wilkinson 28Wilkinson NNP www-nature-com-2208 305 7 , , , www-nature-com-2208 305 8 M. M. NNP www-nature-com-2208 305 9 , , , www-nature-com-2208 305 10 Dumontier Dumontier NNP www-nature-com-2208 305 11 , , , www-nature-com-2208 305 12 M. M. NNP www-nature-com-2208 305 13 & & CC www-nature-com-2208 305 14 Durbin Durbin NNP www-nature-com-2208 305 15 , , , www-nature-com-2208 305 16 P. P. NNP www-nature-com-2208 305 17 DataFairPort DataFairPort NNP www-nature-com-2208 305 18 : : : www-nature-com-2208 305 19 The the DT www-nature-com-2208 305 20 Perl Perl NNP www-nature-com-2208 305 21 libraries library NNS www-nature-com-2208 305 22 version version NN www-nature-com-2208 305 23 0.231 0.231 CD www-nature-com-2208 305 24 10.5281 10.5281 CD www-nature-com-2208 305 25 / / SYM www-nature-com-2208 305 26 zenodo.33584 zenodo.33584 NNP www-nature-com-2208 305 27 ( ( -LRB- www-nature-com-2208 305 28 2015 2015 CD www-nature-com-2208 305 29 ) ) -RRB- www-nature-com-2208 305 30 . . . www-nature-com-2208 306 1 29Data 29Data NNP www-nature-com-2208 306 2 Citation Citation NNP www-nature-com-2208 306 3 Synthesis Synthesis NNP www-nature-com-2208 306 4 Group Group NNP www-nature-com-2208 306 5 : : : www-nature-com-2208 306 6 Joint Joint NNP www-nature-com-2208 306 7 Declaration Declaration NNP www-nature-com-2208 306 8 of of IN www-nature-com-2208 306 9 Data Data NNP www-nature-com-2208 306 10 Citation Citation NNP www-nature-com-2208 306 11 Principles Principles NNPS www-nature-com-2208 306 12 . . . www-nature-com-2208 307 1 San San NNP www-nature-com-2208 307 2 Diego Diego NNP www-nature-com-2208 307 3 CA CA NNP www-nature-com-2208 307 4 : : : www-nature-com-2208 307 5 FORCE11 force11 VB www-nature-com-2208 307 6 https://www.force11.org/datacitation https://www.force11.org/datacitation NN www-nature-com-2208 307 7 ( ( -LRB- www-nature-com-2208 307 8 2014 2014 CD www-nature-com-2208 307 9 ) ) -RRB- www-nature-com-2208 307 10 . . . www-nature-com-2208 308 1 30Ohno 30Ohno NNP www-nature-com-2208 308 2 - - HYPH www-nature-com-2208 308 3 machado machado NNP www-nature-com-2208 308 4 , , , www-nature-com-2208 308 5 L. L. NNP www-nature-com-2208 308 6 et et NNP www-nature-com-2208 308 7 al al NNP www-nature-com-2208 308 8 . . . www-nature-com-2208 309 1 NIH NIH NNP www-nature-com-2208 309 2 BD2 BD2 NNP www-nature-com-2208 309 3 K K NNP www-nature-com-2208 309 4 bioCADDIE bioCADDIE NNP www-nature-com-2208 309 5 white white JJ www-nature-com-2208 309 6 paper paper NN www-nature-com-2208 309 7 — — : www-nature-com-2208 309 8 Data Data NNP www-nature-com-2208 309 9 Discovery Discovery NNP www-nature-com-2208 309 10 Index Index NNP www-nature-com-2208 309 11 . . . www-nature-com-2208 310 1 http://dx.doi.org/10.6084/m9.figshare.1362572 http://dx.doi.org/10.6084/m9.figshare.1362572 NNP www-nature-com-2208 310 2 ( ( -LRB- www-nature-com-2208 310 3 2015 2015 CD www-nature-com-2208 310 4 ) ) -RRB- www-nature-com-2208 310 5 . . . www-nature-com-2208 311 1 31NIH 31nih CD www-nature-com-2208 311 2 BD2 BD2 NNP www-nature-com-2208 311 3 K K NNP www-nature-com-2208 311 4 bioCADDIE bioCADDIE NNP www-nature-com-2208 311 5 WG3 WG3 NNP www-nature-com-2208 311 6 Members Members NNPS www-nature-com-2208 311 7 . . . www-nature-com-2208 312 1 WG3-MetadataSpecifications wg3-metadataspecification NNS www-nature-com-2208 312 2 : : : www-nature-com-2208 312 3 NIH NIH NNP www-nature-com-2208 312 4 BD2 BD2 NNP www-nature-com-2208 312 5 K K NNP www-nature-com-2208 312 6 bioCADDIE bioCADDIE NNP www-nature-com-2208 312 7 Data Data NNP www-nature-com-2208 312 8 Discovery Discovery NNP www-nature-com-2208 312 9 Index Index NNP www-nature-com-2208 312 10 WG3 WG3 NNP www-nature-com-2208 312 11 Metadata Metadata NNP www-nature-com-2208 312 12 Specification Specification NNP www-nature-com-2208 312 13 v1 v1 NN www-nature-com-2208 312 14 doi:10.5281 doi:10.5281 NN www-nature-com-2208 312 15 / / SYM www-nature-com-2208 312 16 zenodo.28019 zenodo.28019 NNP www-nature-com-2208 312 17 ( ( -LRB- www-nature-com-2208 312 18 2015 2015 CD www-nature-com-2208 312 19 ) ) -RRB- www-nature-com-2208 312 20 . . . www-nature-com-2208 313 1 32Musen 32Musen NNP www-nature-com-2208 313 2 , , , www-nature-com-2208 313 3 M. M. NNP www-nature-com-2208 313 4 A. A. NNP www-nature-com-2208 313 5 et et FW www-nature-com-2208 313 6 al al NNP www-nature-com-2208 313 7 . . . www-nature-com-2208 314 1 The the DT www-nature-com-2208 314 2 center center NN www-nature-com-2208 314 3 for for IN www-nature-com-2208 314 4 expanded expand VBN www-nature-com-2208 314 5 data datum NNS www-nature-com-2208 314 6 annotation annotation NN www-nature-com-2208 314 7 and and CC www-nature-com-2208 314 8 retrieval retrieval NN www-nature-com-2208 314 9 . . . www-nature-com-2208 315 1 J. J. NNP www-nature-com-2208 316 1 Am Am NNP www-nature-com-2208 316 2 . . . www-nature-com-2208 317 1 Med Med NNP www-nature-com-2208 317 2 . . . www-nature-com-2208 318 1 Informatics Informatics NNP www-nature-com-2208 318 2 Assoc Assoc NNP www-nature-com-2208 318 3 . . . www-nature-com-2208 319 1 22 22 CD www-nature-com-2208 319 2 , , , www-nature-com-2208 319 3 1148–1152 1148–1152 CD www-nature-com-2208 319 4 ( ( -LRB- www-nature-com-2208 319 5 2015 2015 CD www-nature-com-2208 319 6 ) ) -RRB- www-nature-com-2208 319 7 . . . www-nature-com-2208 320 1 Google Google NNP www-nature-com-2208 320 2 Scholar Scholar NNP www-nature-com-2208 320 3     _SP www-nature-com-2208 320 4 Download Download NNP www-nature-com-2208 320 5 references reference NNS www-nature-com-2208 320 6 Acknowledgements acknowledgement NNS www-nature-com-2208 320 7 The the DT www-nature-com-2208 320 8 original original JJ www-nature-com-2208 320 9 Lorentz Lorentz NNP www-nature-com-2208 320 10 Workshop Workshop NNP www-nature-com-2208 320 11 ‘ ' `` www-nature-com-2208 320 12 Jointly jointly RB www-nature-com-2208 320 13 Designing design VBG www-nature-com-2208 320 14 a a DT www-nature-com-2208 320 15 Data Data NNP www-nature-com-2208 320 16 FAIRport fairport NN www-nature-com-2208 320 17 ’ ' '' www-nature-com-2208 320 18 was be VBD www-nature-com-2208 320 19 organized organize VBN www-nature-com-2208 320 20 by by IN www-nature-com-2208 320 21 Barend Barend NNP www-nature-com-2208 320 22 Mons Mons NNPS www-nature-com-2208 320 23 in in IN www-nature-com-2208 320 24 collaboration collaboration NN www-nature-com-2208 320 25 with with IN www-nature-com-2208 320 26 and and CC www-nature-com-2208 320 27 co co JJ www-nature-com-2208 320 28 - - VBN www-nature-com-2208 320 29 sponsored sponsor VBN www-nature-com-2208 320 30 by by IN www-nature-com-2208 320 31 the the DT www-nature-com-2208 320 32 Lorentz Lorentz NNP www-nature-com-2208 320 33 center center NN www-nature-com-2208 320 34 , , , www-nature-com-2208 320 35 The the DT www-nature-com-2208 320 36 Dutch dutch JJ www-nature-com-2208 320 37 Techcenter Techcenter NNP www-nature-com-2208 320 38 for for IN www-nature-com-2208 320 39 the the DT www-nature-com-2208 320 40 Life Life NNP www-nature-com-2208 320 41 Sciences Sciences NNPS www-nature-com-2208 320 42 and and CC www-nature-com-2208 320 43 the the DT www-nature-com-2208 320 44 Netherlands Netherlands NNP www-nature-com-2208 320 45 eScience eScience NNP www-nature-com-2208 320 46 Center Center NNP www-nature-com-2208 320 47 . . . www-nature-com-2208 321 1 The the DT www-nature-com-2208 321 2 principles principle NNS www-nature-com-2208 321 3 and and CC www-nature-com-2208 321 4 themes theme NNS www-nature-com-2208 321 5 described describe VBN www-nature-com-2208 321 6 in in IN www-nature-com-2208 321 7 this this DT www-nature-com-2208 321 8 manuscript manuscript NN www-nature-com-2208 321 9 represent represent VBP www-nature-com-2208 321 10 the the DT www-nature-com-2208 321 11 significant significant JJ www-nature-com-2208 321 12 voluntary voluntary JJ www-nature-com-2208 321 13 contributions contribution NNS www-nature-com-2208 321 14 and and CC www-nature-com-2208 321 15 participation participation NN www-nature-com-2208 321 16 of of IN www-nature-com-2208 321 17 the the DT www-nature-com-2208 321 18 authors author NNS www-nature-com-2208 321 19 at at IN www-nature-com-2208 321 20 , , , www-nature-com-2208 321 21 and/or and/or CC www-nature-com-2208 321 22 subsequent subsequent JJ www-nature-com-2208 321 23 to to IN www-nature-com-2208 321 24 , , , www-nature-com-2208 321 25 this this DT www-nature-com-2208 321 26 workshop workshop NN www-nature-com-2208 321 27 and and CC www-nature-com-2208 321 28 from from IN www-nature-com-2208 321 29 the the DT www-nature-com-2208 321 30 wider wide JJR www-nature-com-2208 321 31 Force11 Force11 NNP www-nature-com-2208 321 32 , , , www-nature-com-2208 321 33 BD2 BD2 NNP www-nature-com-2208 321 34 K K NNP www-nature-com-2208 321 35 and and CC www-nature-com-2208 321 36 ELIXIR ELIXIR NNP www-nature-com-2208 321 37 communities community NNS www-nature-com-2208 321 38 . . . www-nature-com-2208 322 1 We -PRON- PRP www-nature-com-2208 322 2 also also RB www-nature-com-2208 322 3 acknowledge acknowledge VBP www-nature-com-2208 322 4 and and CC www-nature-com-2208 322 5 thank thank VBP www-nature-com-2208 322 6 the the DT www-nature-com-2208 322 7 organizers organizer NNS www-nature-com-2208 322 8 and and CC www-nature-com-2208 322 9 backers backer NNS www-nature-com-2208 322 10 of of IN www-nature-com-2208 322 11 the the DT www-nature-com-2208 322 12 NBDC NBDC NNP www-nature-com-2208 322 13 / / SYM www-nature-com-2208 322 14 DBCLS DBCLS NNP www-nature-com-2208 322 15 BioHackathon BioHackathon NNP www-nature-com-2208 322 16 2015 2015 CD www-nature-com-2208 322 17 , , , www-nature-com-2208 322 18 where where WRB www-nature-com-2208 322 19 several several JJ www-nature-com-2208 322 20 of of IN www-nature-com-2208 322 21 the the DT www-nature-com-2208 322 22 authors author NNS www-nature-com-2208 322 23 made make VBD www-nature-com-2208 322 24 significant significant JJ www-nature-com-2208 322 25 revisions revision NNS www-nature-com-2208 322 26 to to IN www-nature-com-2208 322 27 the the DT www-nature-com-2208 322 28 FAIR FAIR NNP www-nature-com-2208 322 29 Principles Principles NNPS www-nature-com-2208 322 30 . . . www-nature-com-2208 323 1 Author author NN www-nature-com-2208 323 2 information information NN www-nature-com-2208 323 3 Affiliations Affiliations NNPS www-nature-com-2208 323 4 Center Center NNP www-nature-com-2208 323 5 for for IN www-nature-com-2208 323 6 Plant Plant NNP www-nature-com-2208 323 7 Biotechnology Biotechnology NNP www-nature-com-2208 323 8 and and CC www-nature-com-2208 323 9 Genomics Genomics NNP www-nature-com-2208 323 10 , , , www-nature-com-2208 323 11 Universidad Universidad NNP www-nature-com-2208 323 12 Politécnica Politécnica NNP www-nature-com-2208 323 13 de de NNP www-nature-com-2208 323 14 Madrid Madrid NNP www-nature-com-2208 323 15 , , , www-nature-com-2208 323 16 Madrid Madrid NNP www-nature-com-2208 323 17 , , , www-nature-com-2208 323 18 28223 28223 CD www-nature-com-2208 323 19 , , , www-nature-com-2208 323 20 Spain Spain NNP www-nature-com-2208 323 21 Mark Mark NNP www-nature-com-2208 323 22 D. D. NNP www-nature-com-2208 323 23 Wilkinson Wilkinson NNP www-nature-com-2208 323 24 Stanford Stanford NNP www-nature-com-2208 323 25 University University NNP www-nature-com-2208 323 26 , , , www-nature-com-2208 323 27 Stanford Stanford NNP www-nature-com-2208 323 28 , , , www-nature-com-2208 323 29 94305 94305 CD www-nature-com-2208 323 30 - - SYM www-nature-com-2208 323 31 5411 5411 CD www-nature-com-2208 323 32 , , , www-nature-com-2208 323 33 USA USA NNP www-nature-com-2208 323 34 Michel Michel NNP www-nature-com-2208 323 35 Dumontier Dumontier NNP www-nature-com-2208 323 36 Elsevier Elsevier NNP www-nature-com-2208 323 37 , , , www-nature-com-2208 323 38 , , , www-nature-com-2208 323 39 Amsterdam Amsterdam NNP www-nature-com-2208 323 40 , , , www-nature-com-2208 323 41 1043 1043 CD www-nature-com-2208 323 42 NX NX NNP www-nature-com-2208 323 43 , , , www-nature-com-2208 323 44 The the DT www-nature-com-2208 323 45 Netherlands Netherlands NNP www-nature-com-2208 323 46 IJsbrand IJsbrand NNP www-nature-com-2208 323 47 Jan Jan NNP www-nature-com-2208 323 48 Aalbersberg Aalbersberg NNP www-nature-com-2208 323 49 , , , www-nature-com-2208 323 50   _SP www-nature-com-2208 323 51 Gabrielle Gabrielle NNP www-nature-com-2208 323 52 Appleton Appleton NNP www-nature-com-2208 323 53 , , , www-nature-com-2208 323 54   _SP www-nature-com-2208 323 55 Olivier Olivier NNP www-nature-com-2208 323 56 Dumon Dumon NNP www-nature-com-2208 323 57   _SP www-nature-com-2208 323 58 & & CC www-nature-com-2208 323 59   _SP www-nature-com-2208 323 60 Paul Paul NNP www-nature-com-2208 323 61 Groth Groth NNP www-nature-com-2208 323 62 Nature Nature NNP www-nature-com-2208 323 63 Genetics Genetics NNPS www-nature-com-2208 323 64 , , , www-nature-com-2208 323 65 New New NNP www-nature-com-2208 323 66 York York NNP www-nature-com-2208 323 67 , , , www-nature-com-2208 323 68 10004 10004 CD www-nature-com-2208 323 69 - - SYM www-nature-com-2208 323 70 1562 1562 CD www-nature-com-2208 323 71 , , , www-nature-com-2208 323 72 USA USA NNP www-nature-com-2208 323 73 Myles Myles NNP www-nature-com-2208 323 74 Axton Axton NNP www-nature-com-2208 323 75 Euretos Euretos NNP www-nature-com-2208 323 76 and and CC www-nature-com-2208 323 77 Phortos Phortos NNP www-nature-com-2208 323 78 Consultants Consultants NNP www-nature-com-2208 323 79 , , , www-nature-com-2208 323 80 Rotterdam Rotterdam NNP www-nature-com-2208 323 81 , , , www-nature-com-2208 323 82 2741 2741 CD www-nature-com-2208 323 83 CA CA NNP www-nature-com-2208 323 84 , , , www-nature-com-2208 323 85 The the DT www-nature-com-2208 323 86 Netherlands Netherlands NNP www-nature-com-2208 323 87 Arie Arie NNP www-nature-com-2208 323 88 Baak Baak NNP www-nature-com-2208 323 89 ELIXIR ELIXIR NNP www-nature-com-2208 323 90 , , , www-nature-com-2208 323 91 Wellcome Wellcome NNP www-nature-com-2208 323 92 Genome Genome NNP www-nature-com-2208 323 93 Campus Campus NNP www-nature-com-2208 323 94 , , , www-nature-com-2208 323 95 Hinxton Hinxton NNP www-nature-com-2208 323 96 , , , www-nature-com-2208 323 97 CB10 CB10 NNP www-nature-com-2208 323 98 1SA 1SA NNP www-nature-com-2208 323 99 , , , www-nature-com-2208 323 100 UK UK NNP www-nature-com-2208 323 101 Niklas Niklas NNP www-nature-com-2208 323 102 Blomberg Blomberg NNP www-nature-com-2208 323 103 Lygature Lygature NNP www-nature-com-2208 323 104 , , , www-nature-com-2208 323 105 Eindhoven Eindhoven NNP www-nature-com-2208 323 106 , , , www-nature-com-2208 323 107 5656 5656 CD www-nature-com-2208 323 108 AG AG NNP www-nature-com-2208 323 109 , , , www-nature-com-2208 323 110 The the DT www-nature-com-2208 323 111 Netherlands Netherlands NNP www-nature-com-2208 323 112 Jan Jan NNP www-nature-com-2208 323 113 - - HYPH www-nature-com-2208 323 114 Willem Willem NNP www-nature-com-2208 323 115 Boiten Boiten NNP www-nature-com-2208 323 116 Vrije Vrije NNP www-nature-com-2208 323 117 Universiteit Universiteit NNP www-nature-com-2208 323 118 Amsterdam Amsterdam NNP www-nature-com-2208 323 119 , , , www-nature-com-2208 323 120 Dutch Dutch NNP www-nature-com-2208 323 121 Techcenter Techcenter NNP www-nature-com-2208 323 122 for for IN www-nature-com-2208 323 123 Life Life NNP www-nature-com-2208 323 124 Sciences Sciences NNPS www-nature-com-2208 323 125 , , , www-nature-com-2208 323 126 Amsterdam Amsterdam NNP www-nature-com-2208 323 127 , , , www-nature-com-2208 323 128 1081 1081 CD www-nature-com-2208 323 129 HV HV NNP www-nature-com-2208 323 130 , , , www-nature-com-2208 323 131 The the DT www-nature-com-2208 323 132 Netherlands Netherlands NNP www-nature-com-2208 323 133 Luiz Luiz NNP www-nature-com-2208 323 134 Bonino Bonino NNP www-nature-com-2208 323 135 da da NNP www-nature-com-2208 323 136 Silva Silva NNP www-nature-com-2208 323 137 Santos Santos NNP www-nature-com-2208 323 138 Office Office NNP www-nature-com-2208 323 139 of of IN www-nature-com-2208 323 140 the the DT www-nature-com-2208 323 141 Director Director NNP www-nature-com-2208 323 142 , , , www-nature-com-2208 323 143 National National NNP www-nature-com-2208 323 144 Institutes Institutes NNPS www-nature-com-2208 323 145 of of IN www-nature-com-2208 323 146 Health Health NNP www-nature-com-2208 323 147 , , , www-nature-com-2208 323 148 Rockville Rockville NNP www-nature-com-2208 323 149 , , , www-nature-com-2208 323 150 20892 20892 CD www-nature-com-2208 323 151 , , , www-nature-com-2208 323 152 USA USA NNP www-nature-com-2208 323 153 Philip Philip NNP www-nature-com-2208 323 154 E. E. NNP www-nature-com-2208 323 155 Bourne Bourne NNP www-nature-com-2208 323 156 TNO TNO NNP www-nature-com-2208 323 157 , , , www-nature-com-2208 323 158 Zeist Zeist NNP www-nature-com-2208 323 159 , , , www-nature-com-2208 323 160 3700 3700 CD www-nature-com-2208 323 161 AJ AJ NNP www-nature-com-2208 323 162 , , , www-nature-com-2208 323 163 The the DT www-nature-com-2208 323 164 Netherlands Netherlands NNP www-nature-com-2208 323 165 Jildau Jildau NNP www-nature-com-2208 323 166 Bouwman Bouwman NNP www-nature-com-2208 323 167 Department Department NNP www-nature-com-2208 323 168 of of IN www-nature-com-2208 323 169 Genetics Genetics NNP www-nature-com-2208 323 170 , , , www-nature-com-2208 323 171 University University NNP www-nature-com-2208 323 172 of of IN www-nature-com-2208 323 173 Leicester Leicester NNP www-nature-com-2208 323 174 , , , www-nature-com-2208 323 175 Leicester Leicester NNP www-nature-com-2208 323 176 , , , www-nature-com-2208 323 177 LE1 LE1 NNP www-nature-com-2208 323 178 7RH 7RH NNP www-nature-com-2208 323 179 , , , www-nature-com-2208 323 180 UK UK NNP www-nature-com-2208 323 181 Anthony Anthony NNP www-nature-com-2208 323 182 J. J. NNP www-nature-com-2208 323 183 Brookes Brookes NNP www-nature-com-2208 323 184 Harvard Harvard NNP www-nature-com-2208 323 185 Medical Medical NNP www-nature-com-2208 323 186 School School NNP www-nature-com-2208 323 187 , , , www-nature-com-2208 323 188 Boston Boston NNP www-nature-com-2208 323 189 , , , www-nature-com-2208 323 190 MA MA NNP www-nature-com-2208 323 191 02115 02115 CD www-nature-com-2208 323 192 , , , www-nature-com-2208 323 193 Massachusetts Massachusetts NNP www-nature-com-2208 323 194 , , , www-nature-com-2208 323 195 USA USA NNP www-nature-com-2208 323 196 Tim Tim NNP www-nature-com-2208 323 197 Clark Clark NNP www-nature-com-2208 323 198 Harvard Harvard NNP www-nature-com-2208 323 199 University University NNP www-nature-com-2208 323 200 , , , www-nature-com-2208 323 201 Cambridge Cambridge NNP www-nature-com-2208 323 202 , , , www-nature-com-2208 323 203 MA MA NNP www-nature-com-2208 323 204 02138 02138 CD www-nature-com-2208 323 205 , , , www-nature-com-2208 323 206 Massachusetts Massachusetts NNP www-nature-com-2208 323 207 , , , www-nature-com-2208 323 208 USA USA NNP www-nature-com-2208 323 209 Mercè Mercè NNP www-nature-com-2208 323 210 Crosas Crosas NNP www-nature-com-2208 323 211 Data Data NNP www-nature-com-2208 323 212 Archiving Archiving NNP www-nature-com-2208 323 213 and and CC www-nature-com-2208 323 214 Networked Networked NNP www-nature-com-2208 323 215 Services Services NNPS www-nature-com-2208 323 216 ( ( -LRB- www-nature-com-2208 323 217 DANS DANS NNP www-nature-com-2208 323 218 ) ) -RRB- www-nature-com-2208 323 219 , , , www-nature-com-2208 323 220 The the DT www-nature-com-2208 323 221 Hague Hague NNP www-nature-com-2208 323 222 , , , www-nature-com-2208 323 223 2593 2593 CD www-nature-com-2208 323 224 HW HW NNP www-nature-com-2208 323 225 , , , www-nature-com-2208 323 226 The the DT www-nature-com-2208 323 227 Netherlands Netherlands NNP www-nature-com-2208 323 228 Ingrid Ingrid NNP www-nature-com-2208 323 229 Dillo Dillo NNP www-nature-com-2208 323 230 GigaScience GigaScience NNP www-nature-com-2208 323 231 , , , www-nature-com-2208 323 232 Beijing Beijing NNP www-nature-com-2208 323 233 Genomics Genomics NNP www-nature-com-2208 323 234 Institute Institute NNP www-nature-com-2208 323 235 , , , www-nature-com-2208 323 236 Shenzhen Shenzhen NNP www-nature-com-2208 323 237 , , , www-nature-com-2208 323 238 518083 518083 CD www-nature-com-2208 323 239 , , , www-nature-com-2208 323 240 China China NNP www-nature-com-2208 323 241 Scott Scott NNP www-nature-com-2208 323 242 Edmunds Edmunds NNP www-nature-com-2208 323 243 Department Department NNP www-nature-com-2208 323 244 of of IN www-nature-com-2208 323 245 Bioinformatics Bioinformatics NNP www-nature-com-2208 323 246 , , , www-nature-com-2208 323 247 Maastricht Maastricht NNP www-nature-com-2208 323 248 University University NNP www-nature-com-2208 323 249 , , , www-nature-com-2208 323 250 Maastricht Maastricht NNP www-nature-com-2208 323 251 , , , www-nature-com-2208 323 252 6200 6200 CD www-nature-com-2208 323 253 MD MD NNP www-nature-com-2208 323 254 , , , www-nature-com-2208 323 255 The the DT www-nature-com-2208 323 256 Netherlands Netherlands NNP www-nature-com-2208 323 257 Chris Chris NNP www-nature-com-2208 323 258 T. T. NNP www-nature-com-2208 323 259 Evelo Evelo NNP www-nature-com-2208 323 260 Wageningen Wageningen NNP www-nature-com-2208 323 261 UR UR NNP www-nature-com-2208 323 262 Plant Plant NNP www-nature-com-2208 323 263 Breeding Breeding NNP www-nature-com-2208 323 264 , , , www-nature-com-2208 323 265 Wageningen Wageningen NNP www-nature-com-2208 323 266 , , , www-nature-com-2208 323 267 6708 6708 CD www-nature-com-2208 323 268 PB PB NNP www-nature-com-2208 323 269 , , , www-nature-com-2208 323 270 The the DT www-nature-com-2208 323 271 Netherlands Netherlands NNP www-nature-com-2208 323 272 Richard Richard NNP www-nature-com-2208 323 273 Finkers Finkers NNP www-nature-com-2208 323 274 Oxford Oxford NNP www-nature-com-2208 323 275 e e NNP www-nature-com-2208 323 276 - - : www-nature-com-2208 323 277 Research Research NNP www-nature-com-2208 323 278 Center Center NNP www-nature-com-2208 323 279 , , , www-nature-com-2208 323 280 University University NNP www-nature-com-2208 323 281 of of IN www-nature-com-2208 323 282 Oxford Oxford NNP www-nature-com-2208 323 283 , , , www-nature-com-2208 323 284 Oxford Oxford NNP www-nature-com-2208 323 285 , , , www-nature-com-2208 323 286 OX1 OX1 NNP www-nature-com-2208 323 287 3QG 3QG NNP www-nature-com-2208 323 288 , , , www-nature-com-2208 323 289 UK UK NNP www-nature-com-2208 323 290 Alejandra Alejandra NNP www-nature-com-2208 323 291 Gonzalez Gonzalez NNP www-nature-com-2208 323 292 - - HYPH www-nature-com-2208 323 293 Beltran Beltran NNP www-nature-com-2208 323 294 , , , www-nature-com-2208 323 295   _SP www-nature-com-2208 323 296 Philippe Philippe NNP www-nature-com-2208 323 297 Rocca Rocca NNP www-nature-com-2208 323 298 - - HYPH www-nature-com-2208 323 299 Serra Serra NNP www-nature-com-2208 323 300   _SP www-nature-com-2208 323 301 & & CC www-nature-com-2208 323 302   _SP www-nature-com-2208 323 303 Susanna Susanna NNP www-nature-com-2208 323 304 - - HYPH www-nature-com-2208 323 305 Assunta Assunta NNP www-nature-com-2208 323 306 Sansone Sansone NNP www-nature-com-2208 323 307 Heriot Heriot NNP www-nature-com-2208 323 308 - - HYPH www-nature-com-2208 323 309 Watt Watt NNP www-nature-com-2208 323 310 University University NNP www-nature-com-2208 323 311 , , , www-nature-com-2208 323 312 Edinburgh Edinburgh NNP www-nature-com-2208 323 313 , , , www-nature-com-2208 323 314 EH14 EH14 NNP www-nature-com-2208 323 315 4AS 4as CD www-nature-com-2208 323 316 , , , www-nature-com-2208 323 317 UK UK NNP www-nature-com-2208 323 318 Alasdair Alasdair NNP www-nature-com-2208 323 319 J.G. J.G. NNP www-nature-com-2208 324 1 Gray Gray NNP www-nature-com-2208 324 2 School School NNP www-nature-com-2208 324 3 of of IN www-nature-com-2208 324 4 Computer Computer NNP www-nature-com-2208 324 5 Science Science NNP www-nature-com-2208 324 6 , , , www-nature-com-2208 324 7 University University NNP www-nature-com-2208 324 8 of of IN www-nature-com-2208 324 9 Manchester Manchester NNP www-nature-com-2208 324 10 , , , www-nature-com-2208 324 11 Manchester Manchester NNP www-nature-com-2208 324 12 , , , www-nature-com-2208 324 13 M13 M13 NNP www-nature-com-2208 324 14 9PL 9PL NNP www-nature-com-2208 324 15 , , , www-nature-com-2208 324 16 UK UK NNP www-nature-com-2208 324 17 Carole Carole NNP www-nature-com-2208 324 18 Goble Goble NNP www-nature-com-2208 324 19 Center Center NNP www-nature-com-2208 324 20 for for IN www-nature-com-2208 324 21 Research Research NNP www-nature-com-2208 324 22 in in IN www-nature-com-2208 324 23 Biological Biological NNP www-nature-com-2208 324 24 Systems Systems NNP www-nature-com-2208 324 25 , , , www-nature-com-2208 324 26 School School NNP www-nature-com-2208 324 27 of of IN www-nature-com-2208 324 28 Medicine Medicine NNP www-nature-com-2208 324 29 , , , www-nature-com-2208 324 30 University University NNP www-nature-com-2208 324 31 of of IN www-nature-com-2208 324 32 California California NNP www-nature-com-2208 324 33 San San NNP www-nature-com-2208 324 34 Diego Diego NNP www-nature-com-2208 324 35 , , , www-nature-com-2208 324 36 , , , www-nature-com-2208 324 37 La La NNP www-nature-com-2208 324 38 Jolla Jolla NNP www-nature-com-2208 324 39 , , , www-nature-com-2208 324 40 92093 92093 CD www-nature-com-2208 324 41 - - HYPH www-nature-com-2208 324 42 0446 0446 CD www-nature-com-2208 324 43 , , , www-nature-com-2208 324 44 California California NNP www-nature-com-2208 324 45 , , , www-nature-com-2208 324 46 USA USA NNP www-nature-com-2208 324 47 Jeffrey Jeffrey NNP www-nature-com-2208 324 48 S. S. NNP www-nature-com-2208 324 49 Grethe Grethe NNP www-nature-com-2208 324 50 Dutch Dutch NNP www-nature-com-2208 324 51 Techcenter Techcenter NNP www-nature-com-2208 324 52 for for IN www-nature-com-2208 324 53 the the DT www-nature-com-2208 324 54 Life Life NNP www-nature-com-2208 324 55 Sciences Sciences NNPS www-nature-com-2208 324 56 , , , www-nature-com-2208 324 57 Utrecht Utrecht NNP www-nature-com-2208 324 58 , , , www-nature-com-2208 324 59 3501 3501 CD www-nature-com-2208 324 60 DE DE NNP www-nature-com-2208 324 61 , , , www-nature-com-2208 324 62 The the DT www-nature-com-2208 324 63 Netherlands Netherlands NNP www-nature-com-2208 324 64 Jaap Jaap NNP www-nature-com-2208 324 65 Heringa Heringa NNP www-nature-com-2208 324 66   _SP www-nature-com-2208 324 67 & & CC www-nature-com-2208 324 68   _SP www-nature-com-2208 324 69 Ruben Ruben NNP www-nature-com-2208 324 70 Kok Kok NNP www-nature-com-2208 324 71 Department Department NNP www-nature-com-2208 324 72 of of IN www-nature-com-2208 324 73 Human Human NNP www-nature-com-2208 324 74 Genetics Genetics NNPS www-nature-com-2208 324 75 , , , www-nature-com-2208 324 76 Leiden Leiden NNP www-nature-com-2208 324 77 University University NNP www-nature-com-2208 324 78 Medical Medical NNP www-nature-com-2208 324 79 Center Center NNP www-nature-com-2208 324 80 , , , www-nature-com-2208 324 81 Dutch Dutch NNP www-nature-com-2208 324 82 Techcenter Techcenter NNP www-nature-com-2208 324 83 for for IN www-nature-com-2208 324 84 the the DT www-nature-com-2208 324 85 Life Life NNP www-nature-com-2208 324 86 Sciences Sciences NNPS www-nature-com-2208 324 87 , , , www-nature-com-2208 324 88 Leiden Leiden NNP www-nature-com-2208 324 89 , , , www-nature-com-2208 324 90 2300 2300 CD www-nature-com-2208 324 91 RC rc NN www-nature-com-2208 324 92 , , , www-nature-com-2208 324 93 The the DT www-nature-com-2208 324 94 Netherlands Netherlands NNP www-nature-com-2208 324 95 Peter Peter NNP www-nature-com-2208 324 96 A.C A.C NNP www-nature-com-2208 324 97 ’ ' '' www-nature-com-2208 324 98 t t NNP www-nature-com-2208 324 99 Hoen Hoen NNP www-nature-com-2208 324 100 Dutch Dutch NNP www-nature-com-2208 324 101 TechCenter TechCenter NNP www-nature-com-2208 324 102 for for IN www-nature-com-2208 324 103 Life Life NNP www-nature-com-2208 324 104 Sciences Sciences NNPS www-nature-com-2208 324 105 and and CC www-nature-com-2208 324 106 ELIXIR ELIXIR NNP www-nature-com-2208 324 107 - - HYPH www-nature-com-2208 324 108 NL NL NNP www-nature-com-2208 324 109 , , , www-nature-com-2208 324 110 Utrecht Utrecht NNP www-nature-com-2208 324 111 , , , www-nature-com-2208 324 112 3501 3501 CD www-nature-com-2208 324 113 DE DE NNP www-nature-com-2208 324 114 , , , www-nature-com-2208 324 115 The the DT www-nature-com-2208 324 116 Netherlands Netherlands NNP www-nature-com-2208 324 117 Rob Rob NNP www-nature-com-2208 324 118 Hooft Hooft NNP www-nature-com-2208 324 119 VU VU NNP www-nature-com-2208 324 120 University University NNP www-nature-com-2208 324 121 Amsterdam Amsterdam NNP www-nature-com-2208 324 122 , , , www-nature-com-2208 324 123 Amsterdam Amsterdam NNP www-nature-com-2208 324 124 , , , www-nature-com-2208 324 125 1081 1081 CD www-nature-com-2208 324 126 HV HV NNP www-nature-com-2208 324 127 , , , www-nature-com-2208 324 128 The the DT www-nature-com-2208 324 129 Netherlands Netherlands NNP www-nature-com-2208 324 130 Tobias Tobias NNP www-nature-com-2208 324 131 Kuhn Kuhn NNP www-nature-com-2208 324 132 Leiden Leiden NNP www-nature-com-2208 324 133 Center Center NNP www-nature-com-2208 324 134 of of IN www-nature-com-2208 324 135 Data Data NNP www-nature-com-2208 324 136 Science Science NNP www-nature-com-2208 324 137 , , , www-nature-com-2208 324 138 Leiden Leiden NNP www-nature-com-2208 324 139 University University NNP www-nature-com-2208 324 140 , , , www-nature-com-2208 324 141 Leiden Leiden NNP www-nature-com-2208 324 142 , , , www-nature-com-2208 324 143 2300 2300 CD www-nature-com-2208 324 144 RA RA NNP www-nature-com-2208 324 145 , , , www-nature-com-2208 324 146 The the DT www-nature-com-2208 324 147 Netherlands Netherlands NNP www-nature-com-2208 324 148 Joost Joost NNP www-nature-com-2208 324 149 Kok Kok NNP www-nature-com-2208 324 150 Netherlands Netherlands NNP www-nature-com-2208 324 151 eScience eScience NNP www-nature-com-2208 324 152 Center Center NNP www-nature-com-2208 324 153 , , , www-nature-com-2208 324 154 Amsterdam Amsterdam NNP www-nature-com-2208 324 155 , , , www-nature-com-2208 324 156 1098 1098 CD www-nature-com-2208 324 157 XG XG NNP www-nature-com-2208 324 158 , , , www-nature-com-2208 324 159 The the DT www-nature-com-2208 324 160 Netherlands Netherlands NNP www-nature-com-2208 324 161 Scott Scott NNP www-nature-com-2208 324 162 J. J. NNP www-nature-com-2208 324 163 Lusher Lusher NNP www-nature-com-2208 324 164 National National NNP www-nature-com-2208 324 165 Center Center NNP www-nature-com-2208 324 166 for for IN www-nature-com-2208 324 167 Microscopy Microscopy NNP www-nature-com-2208 324 168 and and CC www-nature-com-2208 324 169 Imaging Imaging NNP www-nature-com-2208 324 170 Research Research NNP www-nature-com-2208 324 171 , , , www-nature-com-2208 324 172 UCSD UCSD NNP www-nature-com-2208 324 173 , , , www-nature-com-2208 324 174 San San NNP www-nature-com-2208 324 175 Diego Diego NNP www-nature-com-2208 324 176 , , , www-nature-com-2208 324 177 92103 92103 CD www-nature-com-2208 324 178 , , , www-nature-com-2208 324 179 USA USA NNP www-nature-com-2208 324 180 Maryann Maryann NNP www-nature-com-2208 324 181 E. E. NNP www-nature-com-2208 324 182 Martone Martone NNP www-nature-com-2208 324 183 Phortos Phortos NNP www-nature-com-2208 324 184 Consultants Consultants NNPS www-nature-com-2208 324 185 , , , www-nature-com-2208 324 186 San San NNP www-nature-com-2208 324 187 Diego Diego NNP www-nature-com-2208 324 188 , , , www-nature-com-2208 324 189 92011 92011 CD www-nature-com-2208 324 190 , , , www-nature-com-2208 324 191 USA USA NNP www-nature-com-2208 324 192 Albert Albert NNP www-nature-com-2208 324 193 Mons Mons NNP www-nature-com-2208 324 194 SciELO SciELO NNP www-nature-com-2208 324 195 / / SYM www-nature-com-2208 324 196 FAPESP FAPESP NNP www-nature-com-2208 324 197 Program Program NNP www-nature-com-2208 324 198 , , , www-nature-com-2208 324 199 UNIFESP UNIFESP NNP www-nature-com-2208 324 200 Foundation Foundation NNP www-nature-com-2208 324 201 , , , www-nature-com-2208 324 202 São São NNP www-nature-com-2208 324 203 Paulo Paulo NNP www-nature-com-2208 324 204 , , , www-nature-com-2208 324 205 05468 05468 CD www-nature-com-2208 324 206 - - SYM www-nature-com-2208 324 207 901 901 CD www-nature-com-2208 324 208 , , , www-nature-com-2208 324 209 Brazil Brazil NNP www-nature-com-2208 324 210 Abel Abel NNP www-nature-com-2208 324 211 L. L. NNP www-nature-com-2208 324 212 Packer Packer NNP www-nature-com-2208 324 213 Bioinformatics Bioinformatics NNP www-nature-com-2208 324 214 Infrastructure Infrastructure NNP www-nature-com-2208 324 215 for for IN www-nature-com-2208 324 216 Life Life NNP www-nature-com-2208 324 217 Sciences Sciences NNPS www-nature-com-2208 324 218 ( ( -LRB- www-nature-com-2208 324 219 BILS BILS NNP www-nature-com-2208 324 220 ) ) -RRB- www-nature-com-2208 324 221 , , , www-nature-com-2208 324 222 Science Science NNP www-nature-com-2208 324 223 for for IN www-nature-com-2208 324 224 Life Life NNP www-nature-com-2208 324 225 Laboratory Laboratory NNP www-nature-com-2208 324 226 , , , www-nature-com-2208 324 227 Dept Dept NNP www-nature-com-2208 324 228 of of IN www-nature-com-2208 324 229 Cell Cell NNP www-nature-com-2208 324 230 and and CC www-nature-com-2208 324 231 Molecular Molecular NNP www-nature-com-2208 324 232 Biology Biology NNP www-nature-com-2208 324 233 , , , www-nature-com-2208 324 234 Uppsala Uppsala NNP www-nature-com-2208 324 235 University University NNP www-nature-com-2208 324 236 , , , www-nature-com-2208 324 237 Uppsala Uppsala NNP www-nature-com-2208 324 238 , , , www-nature-com-2208 324 239 S-751 S-751 NNP www-nature-com-2208 324 240 24 24 CD www-nature-com-2208 324 241 , , , www-nature-com-2208 324 242 Sweden Sweden NNP www-nature-com-2208 324 243 Bengt Bengt NNP www-nature-com-2208 324 244 Persson Persson NNP www-nature-com-2208 324 245 Leiden Leiden NNP www-nature-com-2208 324 246 University University NNP www-nature-com-2208 324 247 Medical Medical NNP www-nature-com-2208 324 248 Center Center NNP www-nature-com-2208 324 249 , , , www-nature-com-2208 324 250 Leiden Leiden NNP www-nature-com-2208 324 251 , , , www-nature-com-2208 324 252 2333 2333 CD www-nature-com-2208 324 253 ZA ZA NNP www-nature-com-2208 324 254 , , , www-nature-com-2208 324 255 The the DT www-nature-com-2208 324 256 Netherlands Netherlands NNP www-nature-com-2208 324 257 Marco Marco NNP www-nature-com-2208 324 258 Roos Roos NNP www-nature-com-2208 324 259   _SP www-nature-com-2208 324 260 & & CC www-nature-com-2208 324 261   _SP www-nature-com-2208 324 262 Mark Mark NNP www-nature-com-2208 324 263 Thompson Thompson NNP www-nature-com-2208 324 264 Bayer Bayer NNP www-nature-com-2208 324 265 CropScience CropScience NNP www-nature-com-2208 324 266 , , , www-nature-com-2208 324 267 Gent Gent NNP www-nature-com-2208 324 268 Area Area NNP www-nature-com-2208 324 269 , , , www-nature-com-2208 324 270 1831 1831 CD www-nature-com-2208 324 271 , , , www-nature-com-2208 324 272 Belgium Belgium NNP www-nature-com-2208 324 273 Rene Rene NNP www-nature-com-2208 324 274 van van NNP www-nature-com-2208 324 275 Schaik Schaik NNP www-nature-com-2208 324 276 Leiden Leiden NNP www-nature-com-2208 324 277 Institute Institute NNP www-nature-com-2208 324 278 for for IN www-nature-com-2208 324 279 Advanced Advanced NNP www-nature-com-2208 324 280 Computer Computer NNP www-nature-com-2208 324 281 Science Science NNP www-nature-com-2208 324 282 , , , www-nature-com-2208 324 283 Leiden Leiden NNP www-nature-com-2208 324 284 University University NNP www-nature-com-2208 324 285 Medical Medical NNP www-nature-com-2208 324 286 Center Center NNP www-nature-com-2208 324 287 , , , www-nature-com-2208 324 288 Leiden Leiden NNP www-nature-com-2208 324 289 , , , www-nature-com-2208 324 290 2300 2300 CD www-nature-com-2208 324 291 RA RA NNP www-nature-com-2208 324 292 , , , www-nature-com-2208 324 293 The the DT www-nature-com-2208 324 294 Netherlands Netherlands NNP www-nature-com-2208 324 295 Erik Erik NNP www-nature-com-2208 324 296 Schultes Schultes NNP www-nature-com-2208 324 297 Swiss Swiss NNP www-nature-com-2208 324 298 Institute Institute NNP www-nature-com-2208 324 299 of of IN www-nature-com-2208 324 300 Bioinformatics Bioinformatics NNP www-nature-com-2208 324 301 and and CC www-nature-com-2208 324 302 University University NNP www-nature-com-2208 324 303 of of IN www-nature-com-2208 324 304 Basel Basel NNP www-nature-com-2208 324 305 , , , www-nature-com-2208 324 306 Basel Basel NNP www-nature-com-2208 324 307 , , , www-nature-com-2208 324 308 4056 4056 CD www-nature-com-2208 324 309 , , , www-nature-com-2208 324 310 Switzerland Switzerland NNP www-nature-com-2208 324 311 Thierry Thierry NNP www-nature-com-2208 324 312 Sengstag Sengstag NNP www-nature-com-2208 324 313 Cray Cray NNP www-nature-com-2208 324 314 , , , www-nature-com-2208 324 315 Inc. Inc. NNP www-nature-com-2208 324 316 , , , www-nature-com-2208 324 317 Seattle Seattle NNP www-nature-com-2208 324 318 , , , www-nature-com-2208 324 319 98164 98164 CD www-nature-com-2208 324 320 , , , www-nature-com-2208 324 321 USA USA NNP www-nature-com-2208 324 322 Ted Ted NNP www-nature-com-2208 324 323 Slater Slater NNP www-nature-com-2208 324 324 Unaffiliated Unaffiliated NNP www-nature-com-2208 324 325 George George NNP www-nature-com-2208 324 326 Strawn Strawn NNP www-nature-com-2208 324 327 University University NNP www-nature-com-2208 324 328 Medical Medical NNP www-nature-com-2208 324 329 Center Center NNP www-nature-com-2208 324 330 Groningen Groningen NNP www-nature-com-2208 324 331 ( ( -LRB- www-nature-com-2208 324 332 UMCG UMCG NNP www-nature-com-2208 324 333 ) ) -RRB- www-nature-com-2208 324 334 , , , www-nature-com-2208 324 335 University University NNP www-nature-com-2208 324 336 of of IN www-nature-com-2208 324 337 Groningen Groningen NNP www-nature-com-2208 324 338 , , , www-nature-com-2208 324 339 Groningen Groningen NNP www-nature-com-2208 324 340 , , , www-nature-com-2208 324 341 9713 9713 CD www-nature-com-2208 324 342 GZ GZ NNP www-nature-com-2208 324 343 , , , www-nature-com-2208 324 344 The the DT www-nature-com-2208 324 345 Netherlands Netherlands NNP www-nature-com-2208 324 346 Morris Morris NNP www-nature-com-2208 324 347 A. A. NNP www-nature-com-2208 324 348 Swertz Swertz NNP www-nature-com-2208 324 349 Erasmus Erasmus NNP www-nature-com-2208 324 350 MC MC NNP www-nature-com-2208 324 351 , , , www-nature-com-2208 324 352 Rotterdam Rotterdam NNP www-nature-com-2208 324 353 , , , www-nature-com-2208 324 354 3015 3015 CD www-nature-com-2208 324 355 CE CE NNP www-nature-com-2208 324 356 , , , www-nature-com-2208 324 357 The the DT www-nature-com-2208 324 358 Netherlands Netherlands NNP www-nature-com-2208 324 359 Johan Johan NNP www-nature-com-2208 324 360 van van NNP www-nature-com-2208 324 361 der der NNP www-nature-com-2208 324 362 Lei Lei NNP www-nature-com-2208 324 363   _SP www-nature-com-2208 324 364 & & CC www-nature-com-2208 324 365   _SP www-nature-com-2208 324 366 Erik Erik NNP www-nature-com-2208 324 367 van van NNP www-nature-com-2208 324 368 Mulligen Mulligen NNP www-nature-com-2208 324 369 Independent Independent NNP www-nature-com-2208 324 370 Open Open NNP www-nature-com-2208 324 371 Access Access NNP www-nature-com-2208 324 372 and and CC www-nature-com-2208 324 373 Open Open NNP www-nature-com-2208 324 374 Science Science NNP www-nature-com-2208 324 375 Advocate Advocate NNP www-nature-com-2208 324 376 , , , www-nature-com-2208 324 377 Guildford Guildford NNP www-nature-com-2208 324 378 , , , www-nature-com-2208 324 379 GU1 GU1 NNP www-nature-com-2208 324 380 3PW 3pw CD www-nature-com-2208 324 381 , , , www-nature-com-2208 324 382 UK UK NNP www-nature-com-2208 324 383 Jan Jan NNP www-nature-com-2208 324 384 Velterop Velterop NNP www-nature-com-2208 324 385 Micelio Micelio NNP www-nature-com-2208 324 386 , , , www-nature-com-2208 324 387 Antwerp Antwerp NNP www-nature-com-2208 324 388 , , , www-nature-com-2208 324 389 2180 2180 CD www-nature-com-2208 324 390 , , , www-nature-com-2208 324 391 Belgium Belgium NNP www-nature-com-2208 324 392 Andra Andra NNP www-nature-com-2208 324 393 Waagmeester Waagmeester NNP www-nature-com-2208 324 394 Max Max NNP www-nature-com-2208 324 395 Planck Planck NNP www-nature-com-2208 324 396 Compute Compute NNP www-nature-com-2208 324 397 and and CC www-nature-com-2208 324 398 Data Data NNP www-nature-com-2208 324 399 Facility Facility NNP www-nature-com-2208 324 400 , , , www-nature-com-2208 324 401 MPS MPS NNP www-nature-com-2208 324 402 , , , www-nature-com-2208 324 403 Garching Garching NNP www-nature-com-2208 324 404 , , , www-nature-com-2208 324 405 85748 85748 CD www-nature-com-2208 324 406 , , , www-nature-com-2208 324 407 Germany Germany NNP www-nature-com-2208 324 408 Peter Peter NNP www-nature-com-2208 324 409 Wittenburg Wittenburg NNP www-nature-com-2208 324 410 Leiden Leiden NNP www-nature-com-2208 324 411 Institute Institute NNP www-nature-com-2208 324 412 of of IN www-nature-com-2208 324 413 Advanced Advanced NNP www-nature-com-2208 324 414 Computer Computer NNP www-nature-com-2208 324 415 Science Science NNP www-nature-com-2208 324 416 , , , www-nature-com-2208 324 417 Leiden Leiden NNP www-nature-com-2208 324 418 University University NNP www-nature-com-2208 324 419 , , , www-nature-com-2208 324 420 Leiden Leiden NNP www-nature-com-2208 324 421 , , , www-nature-com-2208 324 422 2333 2333 CD www-nature-com-2208 324 423 CA CA NNP www-nature-com-2208 324 424 , , , www-nature-com-2208 324 425 The the DT www-nature-com-2208 324 426 Netherlands Netherlands NNP www-nature-com-2208 324 427 Katherine Katherine NNP www-nature-com-2208 324 428 Wolstencroft Wolstencroft NNP www-nature-com-2208 324 429 Department Department NNP www-nature-com-2208 324 430 of of IN www-nature-com-2208 324 431 Computer Computer NNP www-nature-com-2208 324 432 Science Science NNP www-nature-com-2208 324 433 , , , www-nature-com-2208 324 434 Oxford Oxford NNP www-nature-com-2208 324 435 University University NNP www-nature-com-2208 324 436 , , , www-nature-com-2208 324 437 Oxford Oxford NNP www-nature-com-2208 324 438 , , , www-nature-com-2208 324 439 OX1 OX1 NNP www-nature-com-2208 324 440 3QD 3qd CD www-nature-com-2208 324 441 , , , www-nature-com-2208 324 442 UK UK NNP www-nature-com-2208 324 443 Jun Jun NNP www-nature-com-2208 324 444 Zhao Zhao NNP www-nature-com-2208 324 445 Leiden Leiden NNP www-nature-com-2208 324 446 University University NNP www-nature-com-2208 324 447 Medical Medical NNP www-nature-com-2208 324 448 Center Center NNP www-nature-com-2208 324 449 , , , www-nature-com-2208 324 450 Leiden Leiden NNP www-nature-com-2208 324 451 and and CC www-nature-com-2208 324 452 Dutch Dutch NNP www-nature-com-2208 324 453 TechCenter TechCenter NNP www-nature-com-2208 324 454 for for IN www-nature-com-2208 324 455 Life Life NNP www-nature-com-2208 324 456 Sciences Sciences NNPS www-nature-com-2208 324 457 , , , www-nature-com-2208 324 458 Utrecht Utrecht NNP www-nature-com-2208 324 459 , , , www-nature-com-2208 324 460 2333 2333 CD www-nature-com-2208 324 461 ZA ZA NNP www-nature-com-2208 324 462 , , , www-nature-com-2208 324 463 The the DT www-nature-com-2208 324 464 Netherlands Netherlands NNP www-nature-com-2208 324 465 Barend Barend NNP www-nature-com-2208 324 466 Mons mon NNS www-nature-com-2208 324 467 Netherlands Netherlands NNP www-nature-com-2208 324 468 eScience eScience NNP www-nature-com-2208 324 469 Center Center NNP www-nature-com-2208 324 470 , , , www-nature-com-2208 324 471 Amsterdam Amsterdam NNP www-nature-com-2208 324 472 , , , www-nature-com-2208 324 473 1098 1098 CD www-nature-com-2208 324 474 XG XG NNP www-nature-com-2208 324 475 , , , www-nature-com-2208 324 476 The the DT www-nature-com-2208 324 477 Netherlands Netherlands NNP www-nature-com-2208 324 478 Barend Barend NNP www-nature-com-2208 324 479 Mons Mons NNPS www-nature-com-2208 324 480 Erasmus Erasmus NNP www-nature-com-2208 324 481 MC MC NNP www-nature-com-2208 324 482 , , , www-nature-com-2208 324 483 Rotterdam Rotterdam NNP www-nature-com-2208 324 484 , , , www-nature-com-2208 324 485 3015 3015 CD www-nature-com-2208 324 486 CE CE NNP www-nature-com-2208 324 487 , , , www-nature-com-2208 324 488 The the DT www-nature-com-2208 324 489 Netherlands Netherlands NNP www-nature-com-2208 324 490 Barend Barend NNP www-nature-com-2208 324 491 Mons Mons NNP www-nature-com-2208 324 492 Authors Authors NNP www-nature-com-2208 324 493 Mark Mark NNP www-nature-com-2208 324 494 D. D. NNP www-nature-com-2208 324 495 WilkinsonView WilkinsonView NNP www-nature-com-2208 324 496 author author NN www-nature-com-2208 324 497 publications publication NNS www-nature-com-2208 324 498 You -PRON- PRP www-nature-com-2208 324 499 can can MD www-nature-com-2208 324 500 also also RB www-nature-com-2208 324 501 search search VB www-nature-com-2208 324 502 for for IN www-nature-com-2208 324 503 this this DT www-nature-com-2208 324 504 author author NN www-nature-com-2208 324 505 in in IN www-nature-com-2208 324 506 PubMed PubMed NNP www-nature-com-2208 324 507   _SP www-nature-com-2208 324 508 Google Google NNP www-nature-com-2208 324 509 Scholar Scholar NNP www-nature-com-2208 324 510 Michel Michel NNP www-nature-com-2208 324 511 DumontierView DumontierView NNP www-nature-com-2208 324 512 author author NN www-nature-com-2208 324 513 publications publication NNS www-nature-com-2208 324 514 You -PRON- PRP www-nature-com-2208 324 515 can can MD www-nature-com-2208 324 516 also also RB www-nature-com-2208 324 517 search search VB www-nature-com-2208 324 518 for for IN www-nature-com-2208 324 519 this this DT www-nature-com-2208 324 520 author author NN www-nature-com-2208 324 521 in in IN www-nature-com-2208 324 522 PubMed PubMed NNP www-nature-com-2208 324 523   _SP www-nature-com-2208 324 524 Google Google NNP www-nature-com-2208 324 525 Scholar Scholar NNP www-nature-com-2208 324 526 IJsbrand IJsbrand NNP www-nature-com-2208 324 527 Jan Jan NNP www-nature-com-2208 324 528 AalbersbergView AalbersbergView NNP www-nature-com-2208 324 529 author author NN www-nature-com-2208 324 530 publications publication NNS www-nature-com-2208 324 531 You -PRON- PRP www-nature-com-2208 324 532 can can MD www-nature-com-2208 324 533 also also RB www-nature-com-2208 324 534 search search VB www-nature-com-2208 324 535 for for IN www-nature-com-2208 324 536 this this DT www-nature-com-2208 324 537 author author NN www-nature-com-2208 324 538 in in IN www-nature-com-2208 324 539 PubMed PubMed NNP www-nature-com-2208 324 540   _SP www-nature-com-2208 324 541 Google Google NNP www-nature-com-2208 324 542 Scholar Scholar NNP www-nature-com-2208 324 543 Gabrielle Gabrielle NNP www-nature-com-2208 324 544 AppletonView AppletonView NNP www-nature-com-2208 324 545 author author NN www-nature-com-2208 324 546 publications publication NNS www-nature-com-2208 324 547 You -PRON- PRP www-nature-com-2208 324 548 can can MD www-nature-com-2208 324 549 also also RB www-nature-com-2208 324 550 search search VB www-nature-com-2208 324 551 for for IN www-nature-com-2208 324 552 this this DT www-nature-com-2208 324 553 author author NN www-nature-com-2208 324 554 in in IN www-nature-com-2208 324 555 PubMed PubMed NNP www-nature-com-2208 324 556   _SP www-nature-com-2208 324 557 Google Google NNP www-nature-com-2208 324 558 Scholar Scholar NNP www-nature-com-2208 324 559 Myles Myles NNPS www-nature-com-2208 324 560 AxtonView AxtonView NNP www-nature-com-2208 324 561 author author NN www-nature-com-2208 324 562 publications publication NNS www-nature-com-2208 324 563 You -PRON- PRP www-nature-com-2208 324 564 can can MD www-nature-com-2208 324 565 also also RB www-nature-com-2208 324 566 search search VB www-nature-com-2208 324 567 for for IN www-nature-com-2208 324 568 this this DT www-nature-com-2208 324 569 author author NN www-nature-com-2208 324 570 in in IN www-nature-com-2208 324 571 PubMed PubMed NNP www-nature-com-2208 324 572   _SP www-nature-com-2208 324 573 Google Google NNP www-nature-com-2208 324 574 Scholar Scholar NNP www-nature-com-2208 324 575 Arie Arie NNP www-nature-com-2208 324 576 BaakView BaakView NNP www-nature-com-2208 324 577 author author NN www-nature-com-2208 324 578 publications publication NNS www-nature-com-2208 324 579 You -PRON- PRP www-nature-com-2208 324 580 can can MD www-nature-com-2208 324 581 also also RB www-nature-com-2208 324 582 search search VB www-nature-com-2208 324 583 for for IN www-nature-com-2208 324 584 this this DT www-nature-com-2208 324 585 author author NN www-nature-com-2208 324 586 in in IN www-nature-com-2208 324 587 PubMed PubMed NNP www-nature-com-2208 324 588   _SP www-nature-com-2208 324 589 Google Google NNP www-nature-com-2208 324 590 Scholar Scholar NNP www-nature-com-2208 324 591 Niklas Niklas NNP www-nature-com-2208 324 592 BlombergView BlombergView NNP www-nature-com-2208 324 593 author author NN www-nature-com-2208 324 594 publications publication NNS www-nature-com-2208 324 595 You -PRON- PRP www-nature-com-2208 324 596 can can MD www-nature-com-2208 324 597 also also RB www-nature-com-2208 324 598 search search VB www-nature-com-2208 324 599 for for IN www-nature-com-2208 324 600 this this DT www-nature-com-2208 324 601 author author NN www-nature-com-2208 324 602 in in IN www-nature-com-2208 324 603 PubMed PubMed NNP www-nature-com-2208 324 604   _SP www-nature-com-2208 324 605 Google Google NNP www-nature-com-2208 324 606 Scholar Scholar NNP www-nature-com-2208 324 607 Jan Jan NNP www-nature-com-2208 324 608 - - HYPH www-nature-com-2208 324 609 Willem Willem NNP www-nature-com-2208 324 610 BoitenView BoitenView NNP www-nature-com-2208 324 611 author author NN www-nature-com-2208 324 612 publications publication NNS www-nature-com-2208 324 613 You -PRON- PRP www-nature-com-2208 324 614 can can MD www-nature-com-2208 324 615 also also RB www-nature-com-2208 324 616 search search VB www-nature-com-2208 324 617 for for IN www-nature-com-2208 324 618 this this DT www-nature-com-2208 324 619 author author NN www-nature-com-2208 324 620 in in IN www-nature-com-2208 324 621 PubMed PubMed NNP www-nature-com-2208 324 622   _SP www-nature-com-2208 324 623 Google Google NNP www-nature-com-2208 324 624 Scholar Scholar NNP www-nature-com-2208 324 625 Luiz Luiz NNP www-nature-com-2208 324 626 Bonino Bonino NNP www-nature-com-2208 324 627 da da NNP www-nature-com-2208 324 628 Silva Silva NNP www-nature-com-2208 324 629 SantosView SantosView NNP www-nature-com-2208 324 630 author author NN www-nature-com-2208 324 631 publications publication NNS www-nature-com-2208 324 632 You -PRON- PRP www-nature-com-2208 324 633 can can MD www-nature-com-2208 324 634 also also RB www-nature-com-2208 324 635 search search VB www-nature-com-2208 324 636 for for IN www-nature-com-2208 324 637 this this DT www-nature-com-2208 324 638 author author NN www-nature-com-2208 324 639 in in IN www-nature-com-2208 324 640 PubMed PubMed NNP www-nature-com-2208 324 641   _SP www-nature-com-2208 324 642 Google Google NNP www-nature-com-2208 324 643 Scholar Scholar NNP www-nature-com-2208 324 644 Philip Philip NNP www-nature-com-2208 324 645 E. E. NNP www-nature-com-2208 324 646 BourneView BourneView NNP www-nature-com-2208 324 647 author author NN www-nature-com-2208 324 648 publications publication NNS www-nature-com-2208 324 649 You -PRON- PRP www-nature-com-2208 324 650 can can MD www-nature-com-2208 324 651 also also RB www-nature-com-2208 324 652 search search VB www-nature-com-2208 324 653 for for IN www-nature-com-2208 324 654 this this DT www-nature-com-2208 324 655 author author NN www-nature-com-2208 324 656 in in IN www-nature-com-2208 324 657 PubMed PubMed NNP www-nature-com-2208 324 658   _SP www-nature-com-2208 324 659 Google Google NNP www-nature-com-2208 324 660 Scholar Scholar NNP www-nature-com-2208 324 661 Jildau Jildau NNP www-nature-com-2208 324 662 BouwmanView BouwmanView NNP www-nature-com-2208 324 663 author author NN www-nature-com-2208 324 664 publications publication NNS www-nature-com-2208 324 665 You -PRON- PRP www-nature-com-2208 324 666 can can MD www-nature-com-2208 324 667 also also RB www-nature-com-2208 324 668 search search VB www-nature-com-2208 324 669 for for IN www-nature-com-2208 324 670 this this DT www-nature-com-2208 324 671 author author NN www-nature-com-2208 324 672 in in IN www-nature-com-2208 324 673 PubMed PubMed NNP www-nature-com-2208 324 674   _SP www-nature-com-2208 324 675 Google Google NNP www-nature-com-2208 324 676 Scholar Scholar NNP www-nature-com-2208 324 677 Anthony Anthony NNP www-nature-com-2208 324 678 J. J. NNP www-nature-com-2208 324 679 BrookesView BrookesView NNP www-nature-com-2208 324 680 author author NN www-nature-com-2208 324 681 publications publication NNS www-nature-com-2208 324 682 You -PRON- PRP www-nature-com-2208 324 683 can can MD www-nature-com-2208 324 684 also also RB www-nature-com-2208 324 685 search search VB www-nature-com-2208 324 686 for for IN www-nature-com-2208 324 687 this this DT www-nature-com-2208 324 688 author author NN www-nature-com-2208 324 689 in in IN www-nature-com-2208 324 690 PubMed PubMed NNP www-nature-com-2208 324 691   _SP www-nature-com-2208 324 692 Google Google NNP www-nature-com-2208 324 693 Scholar Scholar NNP www-nature-com-2208 324 694 Tim Tim NNP www-nature-com-2208 324 695 ClarkView ClarkView NNP www-nature-com-2208 324 696 author author NN www-nature-com-2208 324 697 publications publication NNS www-nature-com-2208 324 698 You -PRON- PRP www-nature-com-2208 324 699 can can MD www-nature-com-2208 324 700 also also RB www-nature-com-2208 324 701 search search VB www-nature-com-2208 324 702 for for IN www-nature-com-2208 324 703 this this DT www-nature-com-2208 324 704 author author NN www-nature-com-2208 324 705 in in IN www-nature-com-2208 324 706 PubMed PubMed NNP www-nature-com-2208 324 707   _SP www-nature-com-2208 324 708 Google Google NNP www-nature-com-2208 324 709 Scholar Scholar NNP www-nature-com-2208 324 710 Mercè Mercè NNP www-nature-com-2208 324 711 CrosasView CrosasView NNP www-nature-com-2208 324 712 author author NN www-nature-com-2208 324 713 publications publication NNS www-nature-com-2208 324 714 You -PRON- PRP www-nature-com-2208 324 715 can can MD www-nature-com-2208 324 716 also also RB www-nature-com-2208 324 717 search search VB www-nature-com-2208 324 718 for for IN www-nature-com-2208 324 719 this this DT www-nature-com-2208 324 720 author author NN www-nature-com-2208 324 721 in in IN www-nature-com-2208 324 722 PubMed PubMed NNP www-nature-com-2208 324 723   _SP www-nature-com-2208 324 724 Google Google NNP www-nature-com-2208 324 725 Scholar Scholar NNP www-nature-com-2208 324 726 Ingrid Ingrid NNP www-nature-com-2208 324 727 DilloView DilloView NNP www-nature-com-2208 324 728 author author NN www-nature-com-2208 324 729 publications publication NNS www-nature-com-2208 324 730 You -PRON- PRP www-nature-com-2208 324 731 can can MD www-nature-com-2208 324 732 also also RB www-nature-com-2208 324 733 search search VB www-nature-com-2208 324 734 for for IN www-nature-com-2208 324 735 this this DT www-nature-com-2208 324 736 author author NN www-nature-com-2208 324 737 in in IN www-nature-com-2208 324 738 PubMed PubMed NNP www-nature-com-2208 324 739   _SP www-nature-com-2208 324 740 Google Google NNP www-nature-com-2208 324 741 Scholar Scholar NNP www-nature-com-2208 324 742 Olivier Olivier NNP www-nature-com-2208 324 743 DumonView DumonView NNP www-nature-com-2208 324 744 author author NN www-nature-com-2208 324 745 publications publication NNS www-nature-com-2208 324 746 You -PRON- PRP www-nature-com-2208 324 747 can can MD www-nature-com-2208 324 748 also also RB www-nature-com-2208 324 749 search search VB www-nature-com-2208 324 750 for for IN www-nature-com-2208 324 751 this this DT www-nature-com-2208 324 752 author author NN www-nature-com-2208 324 753 in in IN www-nature-com-2208 324 754 PubMed PubMed NNP www-nature-com-2208 324 755   _SP www-nature-com-2208 324 756 Google Google NNP www-nature-com-2208 324 757 Scholar Scholar NNP www-nature-com-2208 324 758 Scott Scott NNP www-nature-com-2208 324 759 EdmundsView EdmundsView NNP www-nature-com-2208 324 760 author author NN www-nature-com-2208 324 761 publications publication NNS www-nature-com-2208 324 762 You -PRON- PRP www-nature-com-2208 324 763 can can MD www-nature-com-2208 324 764 also also RB www-nature-com-2208 324 765 search search VB www-nature-com-2208 324 766 for for IN www-nature-com-2208 324 767 this this DT www-nature-com-2208 324 768 author author NN www-nature-com-2208 324 769 in in IN www-nature-com-2208 324 770 PubMed PubMed NNP www-nature-com-2208 324 771   _SP www-nature-com-2208 324 772 Google Google NNP www-nature-com-2208 324 773 Scholar Scholar NNP www-nature-com-2208 324 774 Chris Chris NNP www-nature-com-2208 324 775 T. T. NNP www-nature-com-2208 324 776 EveloView EveloView NNP www-nature-com-2208 324 777 author author NN www-nature-com-2208 324 778 publications publication NNS www-nature-com-2208 324 779 You -PRON- PRP www-nature-com-2208 324 780 can can MD www-nature-com-2208 324 781 also also RB www-nature-com-2208 324 782 search search VB www-nature-com-2208 324 783 for for IN www-nature-com-2208 324 784 this this DT www-nature-com-2208 324 785 author author NN www-nature-com-2208 324 786 in in IN www-nature-com-2208 324 787 PubMed PubMed NNP www-nature-com-2208 324 788   _SP www-nature-com-2208 324 789 Google Google NNP www-nature-com-2208 324 790 Scholar Scholar NNP www-nature-com-2208 324 791 Richard Richard NNP www-nature-com-2208 324 792 FinkersView FinkersView NNP www-nature-com-2208 324 793 author author NN www-nature-com-2208 324 794 publications publication NNS www-nature-com-2208 324 795 You -PRON- PRP www-nature-com-2208 324 796 can can MD www-nature-com-2208 324 797 also also RB www-nature-com-2208 324 798 search search VB www-nature-com-2208 324 799 for for IN www-nature-com-2208 324 800 this this DT www-nature-com-2208 324 801 author author NN www-nature-com-2208 324 802 in in IN www-nature-com-2208 324 803 PubMed PubMed NNP www-nature-com-2208 324 804   _SP www-nature-com-2208 324 805 Google Google NNP www-nature-com-2208 324 806 Scholar Scholar NNP www-nature-com-2208 324 807 Alejandra Alejandra NNP www-nature-com-2208 324 808 Gonzalez Gonzalez NNP www-nature-com-2208 324 809 - - HYPH www-nature-com-2208 324 810 BeltranView BeltranView NNP www-nature-com-2208 324 811 author author NN www-nature-com-2208 324 812 publications publication NNS www-nature-com-2208 324 813 You -PRON- PRP www-nature-com-2208 324 814 can can MD www-nature-com-2208 324 815 also also RB www-nature-com-2208 324 816 search search VB www-nature-com-2208 324 817 for for IN www-nature-com-2208 324 818 this this DT www-nature-com-2208 324 819 author author NN www-nature-com-2208 324 820 in in IN www-nature-com-2208 324 821 PubMed PubMed NNP www-nature-com-2208 324 822   _SP www-nature-com-2208 324 823 Google Google NNP www-nature-com-2208 324 824 Scholar Scholar NNP www-nature-com-2208 324 825 Alasdair Alasdair NNP www-nature-com-2208 324 826 J.G. J.G. NNP www-nature-com-2208 325 1 GrayView GrayView NNP www-nature-com-2208 325 2 author author NN www-nature-com-2208 325 3 publications publication NNS www-nature-com-2208 325 4 You -PRON- PRP www-nature-com-2208 325 5 can can MD www-nature-com-2208 325 6 also also RB www-nature-com-2208 325 7 search search VB www-nature-com-2208 325 8 for for IN www-nature-com-2208 325 9 this this DT www-nature-com-2208 325 10 author author NN www-nature-com-2208 325 11 in in IN www-nature-com-2208 325 12 PubMed PubMed NNP www-nature-com-2208 325 13   _SP www-nature-com-2208 325 14 Google Google NNP www-nature-com-2208 325 15 Scholar Scholar NNP www-nature-com-2208 325 16 Paul Paul NNP www-nature-com-2208 325 17 GrothView GrothView NNP www-nature-com-2208 325 18 author author NN www-nature-com-2208 325 19 publications publication NNS www-nature-com-2208 325 20 You -PRON- PRP www-nature-com-2208 325 21 can can MD www-nature-com-2208 325 22 also also RB www-nature-com-2208 325 23 search search VB www-nature-com-2208 325 24 for for IN www-nature-com-2208 325 25 this this DT www-nature-com-2208 325 26 author author NN www-nature-com-2208 325 27 in in IN www-nature-com-2208 325 28 PubMed PubMed NNP www-nature-com-2208 325 29   _SP www-nature-com-2208 325 30 Google Google NNP www-nature-com-2208 325 31 Scholar Scholar NNP www-nature-com-2208 325 32 Carole Carole NNP www-nature-com-2208 325 33 GobleView GobleView NNP www-nature-com-2208 325 34 author author NN www-nature-com-2208 325 35 publications publication NNS www-nature-com-2208 325 36 You -PRON- PRP www-nature-com-2208 325 37 can can MD www-nature-com-2208 325 38 also also RB www-nature-com-2208 325 39 search search VB www-nature-com-2208 325 40 for for IN www-nature-com-2208 325 41 this this DT www-nature-com-2208 325 42 author author NN www-nature-com-2208 325 43 in in IN www-nature-com-2208 325 44 PubMed PubMed NNP www-nature-com-2208 325 45   _SP www-nature-com-2208 325 46 Google Google NNP www-nature-com-2208 325 47 Scholar Scholar NNP www-nature-com-2208 325 48 Jeffrey Jeffrey NNP www-nature-com-2208 325 49 S. S. NNP www-nature-com-2208 325 50 GretheView GretheView NNP www-nature-com-2208 325 51 author author NN www-nature-com-2208 325 52 publications publication NNS www-nature-com-2208 325 53 You -PRON- PRP www-nature-com-2208 325 54 can can MD www-nature-com-2208 325 55 also also RB www-nature-com-2208 325 56 search search VB www-nature-com-2208 325 57 for for IN www-nature-com-2208 325 58 this this DT www-nature-com-2208 325 59 author author NN www-nature-com-2208 325 60 in in IN www-nature-com-2208 325 61 PubMed PubMed NNP www-nature-com-2208 325 62   _SP www-nature-com-2208 325 63 Google Google NNP www-nature-com-2208 325 64 Scholar Scholar NNP www-nature-com-2208 325 65 Jaap Jaap NNP www-nature-com-2208 325 66 HeringaView HeringaView NNP www-nature-com-2208 325 67 author author NN www-nature-com-2208 325 68 publications publication NNS www-nature-com-2208 325 69 You -PRON- PRP www-nature-com-2208 325 70 can can MD www-nature-com-2208 325 71 also also RB www-nature-com-2208 325 72 search search VB www-nature-com-2208 325 73 for for IN www-nature-com-2208 325 74 this this DT www-nature-com-2208 325 75 author author NN www-nature-com-2208 325 76 in in IN www-nature-com-2208 325 77 PubMed PubMed NNP www-nature-com-2208 325 78   _SP www-nature-com-2208 325 79 Google Google NNP www-nature-com-2208 325 80 Scholar Scholar NNP www-nature-com-2208 325 81 Peter Peter NNP www-nature-com-2208 325 82 A.C A.C NNP www-nature-com-2208 325 83 ’ ' '' www-nature-com-2208 325 84 t t NN www-nature-com-2208 325 85 HoenView HoenView NNP www-nature-com-2208 325 86 author author NN www-nature-com-2208 325 87 publications publication NNS www-nature-com-2208 325 88 You -PRON- PRP www-nature-com-2208 325 89 can can MD www-nature-com-2208 325 90 also also RB www-nature-com-2208 325 91 search search VB www-nature-com-2208 325 92 for for IN www-nature-com-2208 325 93 this this DT www-nature-com-2208 325 94 author author NN www-nature-com-2208 325 95 in in IN www-nature-com-2208 325 96 PubMed PubMed NNP www-nature-com-2208 325 97   _SP www-nature-com-2208 325 98 Google Google NNP www-nature-com-2208 325 99 Scholar Scholar NNP www-nature-com-2208 325 100 Rob Rob NNP www-nature-com-2208 325 101 HooftView HooftView NNP www-nature-com-2208 325 102 author author NN www-nature-com-2208 325 103 publications publication NNS www-nature-com-2208 325 104 You -PRON- PRP www-nature-com-2208 325 105 can can MD www-nature-com-2208 325 106 also also RB www-nature-com-2208 325 107 search search VB www-nature-com-2208 325 108 for for IN www-nature-com-2208 325 109 this this DT www-nature-com-2208 325 110 author author NN www-nature-com-2208 325 111 in in IN www-nature-com-2208 325 112 PubMed PubMed NNP www-nature-com-2208 325 113   _SP www-nature-com-2208 325 114 Google Google NNP www-nature-com-2208 325 115 Scholar Scholar NNP www-nature-com-2208 325 116 Tobias Tobias NNP www-nature-com-2208 325 117 KuhnView KuhnView NNP www-nature-com-2208 325 118 author author NN www-nature-com-2208 325 119 publications publication NNS www-nature-com-2208 325 120 You -PRON- PRP www-nature-com-2208 325 121 can can MD www-nature-com-2208 325 122 also also RB www-nature-com-2208 325 123 search search VB www-nature-com-2208 325 124 for for IN www-nature-com-2208 325 125 this this DT www-nature-com-2208 325 126 author author NN www-nature-com-2208 325 127 in in IN www-nature-com-2208 325 128 PubMed PubMed NNP www-nature-com-2208 325 129   _SP www-nature-com-2208 325 130 Google Google NNP www-nature-com-2208 325 131 Scholar Scholar NNP www-nature-com-2208 325 132 Ruben Ruben NNP www-nature-com-2208 325 133 KokView KokView NNP www-nature-com-2208 325 134 author author NN www-nature-com-2208 325 135 publications publication NNS www-nature-com-2208 325 136 You -PRON- PRP www-nature-com-2208 325 137 can can MD www-nature-com-2208 325 138 also also RB www-nature-com-2208 325 139 search search VB www-nature-com-2208 325 140 for for IN www-nature-com-2208 325 141 this this DT www-nature-com-2208 325 142 author author NN www-nature-com-2208 325 143 in in IN www-nature-com-2208 325 144 PubMed PubMed NNP www-nature-com-2208 325 145   _SP www-nature-com-2208 325 146 Google Google NNP www-nature-com-2208 325 147 Scholar Scholar NNP www-nature-com-2208 325 148 Joost Joost NNP www-nature-com-2208 325 149 KokView KokView NNP www-nature-com-2208 325 150 author author NN www-nature-com-2208 325 151 publications publication NNS www-nature-com-2208 325 152 You -PRON- PRP www-nature-com-2208 325 153 can can MD www-nature-com-2208 325 154 also also RB www-nature-com-2208 325 155 search search VB www-nature-com-2208 325 156 for for IN www-nature-com-2208 325 157 this this DT www-nature-com-2208 325 158 author author NN www-nature-com-2208 325 159 in in IN www-nature-com-2208 325 160 PubMed PubMed NNP www-nature-com-2208 325 161   _SP www-nature-com-2208 325 162 Google Google NNP www-nature-com-2208 325 163 Scholar Scholar NNP www-nature-com-2208 325 164 Scott Scott NNP www-nature-com-2208 325 165 J. J. NNP www-nature-com-2208 325 166 LusherView LusherView NNP www-nature-com-2208 325 167 author author NN www-nature-com-2208 325 168 publications publication NNS www-nature-com-2208 325 169 You -PRON- PRP www-nature-com-2208 325 170 can can MD www-nature-com-2208 325 171 also also RB www-nature-com-2208 325 172 search search VB www-nature-com-2208 325 173 for for IN www-nature-com-2208 325 174 this this DT www-nature-com-2208 325 175 author author NN www-nature-com-2208 325 176 in in IN www-nature-com-2208 325 177 PubMed PubMed NNP www-nature-com-2208 325 178   _SP www-nature-com-2208 325 179 Google Google NNP www-nature-com-2208 325 180 Scholar Scholar NNP www-nature-com-2208 325 181 Maryann Maryann NNP www-nature-com-2208 325 182 E. E. NNP www-nature-com-2208 325 183 MartoneView MartoneView NNP www-nature-com-2208 325 184 author author NN www-nature-com-2208 325 185 publications publication NNS www-nature-com-2208 325 186 You -PRON- PRP www-nature-com-2208 325 187 can can MD www-nature-com-2208 325 188 also also RB www-nature-com-2208 325 189 search search VB www-nature-com-2208 325 190 for for IN www-nature-com-2208 325 191 this this DT www-nature-com-2208 325 192 author author NN www-nature-com-2208 325 193 in in IN www-nature-com-2208 325 194 PubMed PubMed NNP www-nature-com-2208 325 195   _SP www-nature-com-2208 325 196 Google Google NNP www-nature-com-2208 325 197 Scholar Scholar NNP www-nature-com-2208 325 198 Albert Albert NNP www-nature-com-2208 325 199 MonsView MonsView NNP www-nature-com-2208 325 200 author author NN www-nature-com-2208 325 201 publications publication NNS www-nature-com-2208 325 202 You -PRON- PRP www-nature-com-2208 325 203 can can MD www-nature-com-2208 325 204 also also RB www-nature-com-2208 325 205 search search VB www-nature-com-2208 325 206 for for IN www-nature-com-2208 325 207 this this DT www-nature-com-2208 325 208 author author NN www-nature-com-2208 325 209 in in IN www-nature-com-2208 325 210 PubMed PubMed NNP www-nature-com-2208 325 211   _SP www-nature-com-2208 325 212 Google Google NNP www-nature-com-2208 325 213 Scholar Scholar NNP www-nature-com-2208 325 214 Abel Abel NNP www-nature-com-2208 325 215 L. L. NNP www-nature-com-2208 325 216 PackerView PackerView NNP www-nature-com-2208 325 217 author author NN www-nature-com-2208 325 218 publications publication NNS www-nature-com-2208 325 219 You -PRON- PRP www-nature-com-2208 325 220 can can MD www-nature-com-2208 325 221 also also RB www-nature-com-2208 325 222 search search VB www-nature-com-2208 325 223 for for IN www-nature-com-2208 325 224 this this DT www-nature-com-2208 325 225 author author NN www-nature-com-2208 325 226 in in IN www-nature-com-2208 325 227 PubMed PubMed NNP www-nature-com-2208 325 228   _SP www-nature-com-2208 325 229 Google Google NNP www-nature-com-2208 325 230 Scholar Scholar NNP www-nature-com-2208 325 231 Bengt Bengt NNP www-nature-com-2208 325 232 PerssonView PerssonView NNP www-nature-com-2208 325 233 author author NN www-nature-com-2208 325 234 publications publication NNS www-nature-com-2208 325 235 You -PRON- PRP www-nature-com-2208 325 236 can can MD www-nature-com-2208 325 237 also also RB www-nature-com-2208 325 238 search search VB www-nature-com-2208 325 239 for for IN www-nature-com-2208 325 240 this this DT www-nature-com-2208 325 241 author author NN www-nature-com-2208 325 242 in in IN www-nature-com-2208 325 243 PubMed PubMed NNP www-nature-com-2208 325 244   _SP www-nature-com-2208 325 245 Google Google NNP www-nature-com-2208 325 246 Scholar Scholar NNP www-nature-com-2208 325 247 Philippe Philippe NNP www-nature-com-2208 325 248 Rocca Rocca NNP www-nature-com-2208 325 249 - - HYPH www-nature-com-2208 325 250 SerraView SerraView NNP www-nature-com-2208 325 251 author author NN www-nature-com-2208 325 252 publications publication NNS www-nature-com-2208 325 253 You -PRON- PRP www-nature-com-2208 325 254 can can MD www-nature-com-2208 325 255 also also RB www-nature-com-2208 325 256 search search VB www-nature-com-2208 325 257 for for IN www-nature-com-2208 325 258 this this DT www-nature-com-2208 325 259 author author NN www-nature-com-2208 325 260 in in IN www-nature-com-2208 325 261 PubMed PubMed NNP www-nature-com-2208 325 262   _SP www-nature-com-2208 325 263 Google Google NNP www-nature-com-2208 325 264 Scholar Scholar NNP www-nature-com-2208 325 265 Marco Marco NNP www-nature-com-2208 325 266 RoosView RoosView NNP www-nature-com-2208 325 267 author author NN www-nature-com-2208 325 268 publications publication NNS www-nature-com-2208 325 269 You -PRON- PRP www-nature-com-2208 325 270 can can MD www-nature-com-2208 325 271 also also RB www-nature-com-2208 325 272 search search VB www-nature-com-2208 325 273 for for IN www-nature-com-2208 325 274 this this DT www-nature-com-2208 325 275 author author NN www-nature-com-2208 325 276 in in IN www-nature-com-2208 325 277 PubMed PubMed NNP www-nature-com-2208 325 278   _SP www-nature-com-2208 325 279 Google Google NNP www-nature-com-2208 325 280 Scholar Scholar NNP www-nature-com-2208 325 281 Rene Rene NNP www-nature-com-2208 325 282 van van NNP www-nature-com-2208 325 283 SchaikView SchaikView NNP www-nature-com-2208 325 284 author author NN www-nature-com-2208 325 285 publications publication NNS www-nature-com-2208 325 286 You -PRON- PRP www-nature-com-2208 325 287 can can MD www-nature-com-2208 325 288 also also RB www-nature-com-2208 325 289 search search VB www-nature-com-2208 325 290 for for IN www-nature-com-2208 325 291 this this DT www-nature-com-2208 325 292 author author NN www-nature-com-2208 325 293 in in IN www-nature-com-2208 325 294 PubMed PubMed NNP www-nature-com-2208 325 295   _SP www-nature-com-2208 325 296 Google Google NNP www-nature-com-2208 325 297 Scholar Scholar NNP www-nature-com-2208 325 298 Susanna Susanna NNP www-nature-com-2208 325 299 - - HYPH www-nature-com-2208 325 300 Assunta Assunta NNP www-nature-com-2208 325 301 SansoneView SansoneView NNP www-nature-com-2208 325 302 author author NN www-nature-com-2208 325 303 publications publication NNS www-nature-com-2208 325 304 You -PRON- PRP www-nature-com-2208 325 305 can can MD www-nature-com-2208 325 306 also also RB www-nature-com-2208 325 307 search search VB www-nature-com-2208 325 308 for for IN www-nature-com-2208 325 309 this this DT www-nature-com-2208 325 310 author author NN www-nature-com-2208 325 311 in in IN www-nature-com-2208 325 312 PubMed PubMed NNP www-nature-com-2208 325 313   _SP www-nature-com-2208 325 314 Google Google NNP www-nature-com-2208 325 315 Scholar Scholar NNP www-nature-com-2208 325 316 Erik Erik NNP www-nature-com-2208 325 317 SchultesView SchultesView NNP www-nature-com-2208 325 318 author author NN www-nature-com-2208 325 319 publications publication NNS www-nature-com-2208 325 320 You -PRON- PRP www-nature-com-2208 325 321 can can MD www-nature-com-2208 325 322 also also RB www-nature-com-2208 325 323 search search VB www-nature-com-2208 325 324 for for IN www-nature-com-2208 325 325 this this DT www-nature-com-2208 325 326 author author NN www-nature-com-2208 325 327 in in IN www-nature-com-2208 325 328 PubMed PubMed NNP www-nature-com-2208 325 329   _SP www-nature-com-2208 325 330 Google Google NNP www-nature-com-2208 325 331 Scholar Scholar NNP www-nature-com-2208 325 332 Thierry Thierry NNP www-nature-com-2208 325 333 SengstagView SengstagView NNP www-nature-com-2208 325 334 author author NN www-nature-com-2208 325 335 publications publication NNS www-nature-com-2208 325 336 You -PRON- PRP www-nature-com-2208 325 337 can can MD www-nature-com-2208 325 338 also also RB www-nature-com-2208 325 339 search search VB www-nature-com-2208 325 340 for for IN www-nature-com-2208 325 341 this this DT www-nature-com-2208 325 342 author author NN www-nature-com-2208 325 343 in in IN www-nature-com-2208 325 344 PubMed PubMed NNP www-nature-com-2208 325 345   _SP www-nature-com-2208 325 346 Google Google NNP www-nature-com-2208 325 347 Scholar Scholar NNP www-nature-com-2208 325 348 Ted Ted NNP www-nature-com-2208 325 349 SlaterView SlaterView NNP www-nature-com-2208 325 350 author author NN www-nature-com-2208 325 351 publications publication NNS www-nature-com-2208 325 352 You -PRON- PRP www-nature-com-2208 325 353 can can MD www-nature-com-2208 325 354 also also RB www-nature-com-2208 325 355 search search VB www-nature-com-2208 325 356 for for IN www-nature-com-2208 325 357 this this DT www-nature-com-2208 325 358 author author NN www-nature-com-2208 325 359 in in IN www-nature-com-2208 325 360 PubMed PubMed NNP www-nature-com-2208 325 361   _SP www-nature-com-2208 325 362 Google Google NNP www-nature-com-2208 325 363 Scholar Scholar NNP www-nature-com-2208 325 364 George George NNP www-nature-com-2208 325 365 StrawnView StrawnView NNP www-nature-com-2208 325 366 author author NN www-nature-com-2208 325 367 publications publication NNS www-nature-com-2208 325 368 You -PRON- PRP www-nature-com-2208 325 369 can can MD www-nature-com-2208 325 370 also also RB www-nature-com-2208 325 371 search search VB www-nature-com-2208 325 372 for for IN www-nature-com-2208 325 373 this this DT www-nature-com-2208 325 374 author author NN www-nature-com-2208 325 375 in in IN www-nature-com-2208 325 376 PubMed PubMed NNP www-nature-com-2208 325 377   _SP www-nature-com-2208 325 378 Google Google NNP www-nature-com-2208 325 379 Scholar Scholar NNP www-nature-com-2208 325 380 Morris Morris NNP www-nature-com-2208 325 381 A. A. NNP www-nature-com-2208 325 382 SwertzView SwertzView NNP www-nature-com-2208 325 383 author author NN www-nature-com-2208 325 384 publications publication NNS www-nature-com-2208 325 385 You -PRON- PRP www-nature-com-2208 325 386 can can MD www-nature-com-2208 325 387 also also RB www-nature-com-2208 325 388 search search VB www-nature-com-2208 325 389 for for IN www-nature-com-2208 325 390 this this DT www-nature-com-2208 325 391 author author NN www-nature-com-2208 325 392 in in IN www-nature-com-2208 325 393 PubMed PubMed NNP www-nature-com-2208 325 394   _SP www-nature-com-2208 325 395 Google Google NNP www-nature-com-2208 325 396 Scholar Scholar NNP www-nature-com-2208 325 397 Mark Mark NNP www-nature-com-2208 325 398 ThompsonView ThompsonView NNP www-nature-com-2208 325 399 author author NN www-nature-com-2208 325 400 publications publication NNS www-nature-com-2208 325 401 You -PRON- PRP www-nature-com-2208 325 402 can can MD www-nature-com-2208 325 403 also also RB www-nature-com-2208 325 404 search search VB www-nature-com-2208 325 405 for for IN www-nature-com-2208 325 406 this this DT www-nature-com-2208 325 407 author author NN www-nature-com-2208 325 408 in in IN www-nature-com-2208 325 409 PubMed PubMed NNP www-nature-com-2208 325 410   _SP www-nature-com-2208 325 411 Google Google NNP www-nature-com-2208 325 412 Scholar Scholar NNP www-nature-com-2208 325 413 Johan Johan NNP www-nature-com-2208 325 414 van van NNP www-nature-com-2208 325 415 der der IN www-nature-com-2208 325 416 LeiView LeiView NNP www-nature-com-2208 325 417 author author NN www-nature-com-2208 325 418 publications publication NNS www-nature-com-2208 325 419 You -PRON- PRP www-nature-com-2208 325 420 can can MD www-nature-com-2208 325 421 also also RB www-nature-com-2208 325 422 search search VB www-nature-com-2208 325 423 for for IN www-nature-com-2208 325 424 this this DT www-nature-com-2208 325 425 author author NN www-nature-com-2208 325 426 in in IN www-nature-com-2208 325 427 PubMed PubMed NNP www-nature-com-2208 325 428   _SP www-nature-com-2208 325 429 Google Google NNP www-nature-com-2208 325 430 Scholar Scholar NNP www-nature-com-2208 325 431 Erik Erik NNP www-nature-com-2208 325 432 van van NNP www-nature-com-2208 325 433 MulligenView MulligenView NNP www-nature-com-2208 325 434 author author NN www-nature-com-2208 325 435 publications publication NNS www-nature-com-2208 325 436 You -PRON- PRP www-nature-com-2208 325 437 can can MD www-nature-com-2208 325 438 also also RB www-nature-com-2208 325 439 search search VB www-nature-com-2208 325 440 for for IN www-nature-com-2208 325 441 this this DT www-nature-com-2208 325 442 author author NN www-nature-com-2208 325 443 in in IN www-nature-com-2208 325 444 PubMed PubMed NNP www-nature-com-2208 325 445   _SP www-nature-com-2208 325 446 Google Google NNP www-nature-com-2208 325 447 Scholar Scholar NNP www-nature-com-2208 325 448 Jan Jan NNP www-nature-com-2208 325 449 VelteropView VelteropView NNP www-nature-com-2208 325 450 author author NN www-nature-com-2208 325 451 publications publication NNS www-nature-com-2208 325 452 You -PRON- PRP www-nature-com-2208 325 453 can can MD www-nature-com-2208 325 454 also also RB www-nature-com-2208 325 455 search search VB www-nature-com-2208 325 456 for for IN www-nature-com-2208 325 457 this this DT www-nature-com-2208 325 458 author author NN www-nature-com-2208 325 459 in in IN www-nature-com-2208 325 460 PubMed PubMed NNP www-nature-com-2208 325 461   _SP www-nature-com-2208 325 462 Google Google NNP www-nature-com-2208 325 463 Scholar Scholar NNP www-nature-com-2208 325 464 Andra Andra NNP www-nature-com-2208 325 465 WaagmeesterView WaagmeesterView NNP www-nature-com-2208 325 466 author author NN www-nature-com-2208 325 467 publications publication NNS www-nature-com-2208 325 468 You -PRON- PRP www-nature-com-2208 325 469 can can MD www-nature-com-2208 325 470 also also RB www-nature-com-2208 325 471 search search VB www-nature-com-2208 325 472 for for IN www-nature-com-2208 325 473 this this DT www-nature-com-2208 325 474 author author NN www-nature-com-2208 325 475 in in IN www-nature-com-2208 325 476 PubMed PubMed NNP www-nature-com-2208 325 477   _SP www-nature-com-2208 325 478 Google Google NNP www-nature-com-2208 325 479 Scholar Scholar NNP www-nature-com-2208 325 480 Peter Peter NNP www-nature-com-2208 325 481 WittenburgView WittenburgView NNP www-nature-com-2208 325 482 author author NN www-nature-com-2208 325 483 publications publication NNS www-nature-com-2208 325 484 You -PRON- PRP www-nature-com-2208 325 485 can can MD www-nature-com-2208 325 486 also also RB www-nature-com-2208 325 487 search search VB www-nature-com-2208 325 488 for for IN www-nature-com-2208 325 489 this this DT www-nature-com-2208 325 490 author author NN www-nature-com-2208 325 491 in in IN www-nature-com-2208 325 492 PubMed PubMed NNP www-nature-com-2208 325 493   _SP www-nature-com-2208 325 494 Google Google NNP www-nature-com-2208 325 495 Scholar Scholar NNP www-nature-com-2208 325 496 Katherine Katherine NNP www-nature-com-2208 325 497 WolstencroftView WolstencroftView NNP www-nature-com-2208 325 498 author author NN www-nature-com-2208 325 499 publications publication NNS www-nature-com-2208 325 500 You -PRON- PRP www-nature-com-2208 325 501 can can MD www-nature-com-2208 325 502 also also RB www-nature-com-2208 325 503 search search VB www-nature-com-2208 325 504 for for IN www-nature-com-2208 325 505 this this DT www-nature-com-2208 325 506 author author NN www-nature-com-2208 325 507 in in IN www-nature-com-2208 325 508 PubMed PubMed NNP www-nature-com-2208 325 509   _SP www-nature-com-2208 325 510 Google Google NNP www-nature-com-2208 325 511 Scholar Scholar NNP www-nature-com-2208 325 512 Jun Jun NNP www-nature-com-2208 325 513 ZhaoView ZhaoView NNP www-nature-com-2208 325 514 author author NN www-nature-com-2208 325 515 publications publication NNS www-nature-com-2208 325 516 You -PRON- PRP www-nature-com-2208 325 517 can can MD www-nature-com-2208 325 518 also also RB www-nature-com-2208 325 519 search search VB www-nature-com-2208 325 520 for for IN www-nature-com-2208 325 521 this this DT www-nature-com-2208 325 522 author author NN www-nature-com-2208 325 523 in in IN www-nature-com-2208 325 524 PubMed PubMed NNP www-nature-com-2208 325 525   _SP www-nature-com-2208 325 526 Google Google NNP www-nature-com-2208 325 527 Scholar Scholar NNP www-nature-com-2208 325 528 Barend Barend NNP www-nature-com-2208 325 529 MonsView MonsView NNP www-nature-com-2208 325 530 author author NN www-nature-com-2208 325 531 publications publication NNS www-nature-com-2208 325 532 You -PRON- PRP www-nature-com-2208 325 533 can can MD www-nature-com-2208 325 534 also also RB www-nature-com-2208 325 535 search search VB www-nature-com-2208 325 536 for for IN www-nature-com-2208 325 537 this this DT www-nature-com-2208 325 538 author author NN www-nature-com-2208 325 539 in in IN www-nature-com-2208 325 540 PubMed PubMed NNP www-nature-com-2208 325 541   _SP www-nature-com-2208 325 542 Google Google NNP www-nature-com-2208 325 543 Scholar Scholar NNP www-nature-com-2208 325 544 Contributions Contributions NNPS www-nature-com-2208 325 545 M.W. M.W. NNP www-nature-com-2208 326 1 was be VBD www-nature-com-2208 326 2 the the DT www-nature-com-2208 326 3 primary primary JJ www-nature-com-2208 326 4 author author NN www-nature-com-2208 326 5 of of IN www-nature-com-2208 326 6 the the DT www-nature-com-2208 326 7 manuscript manuscript NN www-nature-com-2208 326 8 , , , www-nature-com-2208 326 9 and and CC www-nature-com-2208 326 10 participated participate VBD www-nature-com-2208 326 11 extensively extensively RB www-nature-com-2208 326 12 in in IN www-nature-com-2208 326 13 the the DT www-nature-com-2208 326 14 drafting drafting NN www-nature-com-2208 326 15 and and CC www-nature-com-2208 326 16 editing editing NN www-nature-com-2208 326 17 of of IN www-nature-com-2208 326 18 the the DT www-nature-com-2208 326 19 FAIR FAIR NNP www-nature-com-2208 326 20 Principles Principles NNPS www-nature-com-2208 326 21 . . . www-nature-com-2208 327 1 M.D. M.D. NNP www-nature-com-2208 328 1 was be VBD www-nature-com-2208 328 2 significantly significantly RB www-nature-com-2208 328 3 involved involve VBN www-nature-com-2208 328 4 in in IN www-nature-com-2208 328 5 the the DT www-nature-com-2208 328 6 drafting drafting NN www-nature-com-2208 328 7 of of IN www-nature-com-2208 328 8 the the DT www-nature-com-2208 328 9 FAIR FAIR NNP www-nature-com-2208 328 10 Principles Principles NNPS www-nature-com-2208 328 11 . . . www-nature-com-2208 329 1 B.M. B.M. NNP www-nature-com-2208 330 1 conceived conceive VBN www-nature-com-2208 330 2 of of IN www-nature-com-2208 330 3 the the DT www-nature-com-2208 330 4 FAIR FAIR NNP www-nature-com-2208 330 5 Data Data NNP www-nature-com-2208 330 6 Initiative Initiative NNP www-nature-com-2208 330 7 , , , www-nature-com-2208 330 8 contributed contribute VBD www-nature-com-2208 330 9 extensively extensively RB www-nature-com-2208 330 10 to to IN www-nature-com-2208 330 11 the the DT www-nature-com-2208 330 12 drafting drafting NN www-nature-com-2208 330 13 of of IN www-nature-com-2208 330 14 the the DT www-nature-com-2208 330 15 principles principle NNS www-nature-com-2208 330 16 , , , www-nature-com-2208 330 17 and and CC www-nature-com-2208 330 18 to to IN www-nature-com-2208 330 19 this this DT www-nature-com-2208 330 20 manuscript manuscript NN www-nature-com-2208 330 21 text text NN www-nature-com-2208 330 22 . . . www-nature-com-2208 331 1 All all DT www-nature-com-2208 331 2 other other JJ www-nature-com-2208 331 3 authors author NNS www-nature-com-2208 331 4 are be VBP www-nature-com-2208 331 5 listed list VBN www-nature-com-2208 331 6 alphabetically alphabetically RB www-nature-com-2208 331 7 , , , www-nature-com-2208 331 8 and and CC www-nature-com-2208 331 9 contributed contribute VBD www-nature-com-2208 331 10 to to IN www-nature-com-2208 331 11 the the DT www-nature-com-2208 331 12 manuscript manuscript NN www-nature-com-2208 331 13 either either CC www-nature-com-2208 331 14 by by IN www-nature-com-2208 331 15 their -PRON- PRP$ www-nature-com-2208 331 16 participation participation NN www-nature-com-2208 331 17 in in IN www-nature-com-2208 331 18 the the DT www-nature-com-2208 331 19 initial initial JJ www-nature-com-2208 331 20 workshop workshop NN www-nature-com-2208 331 21 and/or and/or CC www-nature-com-2208 331 22 by by IN www-nature-com-2208 331 23 editing edit VBG www-nature-com-2208 331 24 or or CC www-nature-com-2208 331 25 commenting comment VBG www-nature-com-2208 331 26 on on IN www-nature-com-2208 331 27 the the DT www-nature-com-2208 331 28 manuscript manuscript NN www-nature-com-2208 331 29 text text NN www-nature-com-2208 331 30 . . . www-nature-com-2208 332 1 Corresponding correspond VBG www-nature-com-2208 332 2 author author NN www-nature-com-2208 332 3 Correspondence Correspondence NNP www-nature-com-2208 332 4 to to IN www-nature-com-2208 332 5 Barend barend VB www-nature-com-2208 332 6 Mons mon NNS www-nature-com-2208 332 7 . . . www-nature-com-2208 333 1 Ethics Ethics NNP www-nature-com-2208 333 2 declarations declaration NNS www-nature-com-2208 333 3 Competing Competing NNP www-nature-com-2208 333 4 interests interest NNS www-nature-com-2208 333 5 M.A. M.A. NNP www-nature-com-2208 334 1 is be VBZ www-nature-com-2208 334 2 the the DT www-nature-com-2208 334 3 Nature Nature NNP www-nature-com-2208 334 4 Genetics Genetics NNPS www-nature-com-2208 334 5 ’ ’ POS www-nature-com-2208 334 6 Editor Editor NNP www-nature-com-2208 334 7 in in IN www-nature-com-2208 334 8 Chief Chief NNP www-nature-com-2208 334 9 ; ; : www-nature-com-2208 334 10 S.A.S. S.A.S. NNP www-nature-com-2208 335 1 is be VBZ www-nature-com-2208 335 2 Scientific Scientific NNP www-nature-com-2208 335 3 Data Data NNPS www-nature-com-2208 335 4 ’s ’s POS www-nature-com-2208 335 5 Honorary Honorary NNP www-nature-com-2208 335 6 Academic Academic NNP www-nature-com-2208 335 7 Editor Editor NNP www-nature-com-2208 335 8 and and CC www-nature-com-2208 335 9 consultant consultant NN www-nature-com-2208 335 10 . . . www-nature-com-2208 336 1 Rights right NNS www-nature-com-2208 336 2 and and CC www-nature-com-2208 336 3 permissions permission NNS www-nature-com-2208 336 4 This this DT www-nature-com-2208 336 5 work work NN www-nature-com-2208 336 6 is be VBZ www-nature-com-2208 336 7 licensed license VBN www-nature-com-2208 336 8 under under IN www-nature-com-2208 336 9 a a DT www-nature-com-2208 336 10 Creative Creative NNP www-nature-com-2208 336 11 Commons Commons NNP www-nature-com-2208 336 12 Attribution Attribution NNP www-nature-com-2208 336 13 4.0 4.0 CD www-nature-com-2208 336 14 International International NNP www-nature-com-2208 336 15 License License NNP www-nature-com-2208 336 16 . . . www-nature-com-2208 337 1 The the DT www-nature-com-2208 337 2 images image NNS www-nature-com-2208 337 3 or or CC www-nature-com-2208 337 4 other other JJ www-nature-com-2208 337 5 third third JJ www-nature-com-2208 337 6 party party NN www-nature-com-2208 337 7 material material NN www-nature-com-2208 337 8 in in IN www-nature-com-2208 337 9 this this DT www-nature-com-2208 337 10 article article NN www-nature-com-2208 337 11 are be VBP www-nature-com-2208 337 12 included include VBN www-nature-com-2208 337 13 in in IN www-nature-com-2208 337 14 the the DT www-nature-com-2208 337 15 article article NN www-nature-com-2208 337 16 ’s ’s POS www-nature-com-2208 337 17 Creative Creative NNP www-nature-com-2208 337 18 Commons Commons NNP www-nature-com-2208 337 19 license license NN www-nature-com-2208 337 20 , , , www-nature-com-2208 337 21 unless unless IN www-nature-com-2208 337 22 indicated indicate VBN www-nature-com-2208 337 23 otherwise otherwise RB www-nature-com-2208 337 24 in in IN www-nature-com-2208 337 25 the the DT www-nature-com-2208 337 26 credit credit NN www-nature-com-2208 337 27 line line NN www-nature-com-2208 337 28 ; 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