id sid tid token lemma pos en-wikipedia-org-43 1 1 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 1 2 - - HYPH en-wikipedia-org-43 1 3 Wikipedia wikipedia NN en-wikipedia-org-43 1 4 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 1 5 From from IN en-wikipedia-org-43 1 6 Wikipedia Wikipedia NNP en-wikipedia-org-43 1 7 , , , en-wikipedia-org-43 1 8 the the DT en-wikipedia-org-43 1 9 free free JJ en-wikipedia-org-43 1 10 encyclopedia encyclopedia NN en-wikipedia-org-43 1 11       _SP en-wikipedia-org-43 1 12 ( ( -LRB- en-wikipedia-org-43 1 13 Redirected redirect VBN en-wikipedia-org-43 1 14 from from IN en-wikipedia-org-43 1 15 Neurotrophins Neurotrophins NNP en-wikipedia-org-43 1 16 ) ) -RRB- en-wikipedia-org-43 1 17 Jump jump VB en-wikipedia-org-43 1 18 to to IN en-wikipedia-org-43 1 19 navigation navigation NN en-wikipedia-org-43 1 20 Jump Jump NNP en-wikipedia-org-43 1 21 to to TO en-wikipedia-org-43 1 22 search search VB en-wikipedia-org-43 1 23 Not not RB en-wikipedia-org-43 1 24 to to TO en-wikipedia-org-43 1 25 be be VB en-wikipedia-org-43 1 26 confused confuse VBN en-wikipedia-org-43 1 27 with with IN en-wikipedia-org-43 1 28 Neurotropic Neurotropic NNP en-wikipedia-org-43 1 29 . . . en-wikipedia-org-43 2 1 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 2 2 Identifiers Identifiers NNPS en-wikipedia-org-43 2 3 Symbol Symbol NNP en-wikipedia-org-43 2 4 NGF NGF NNP en-wikipedia-org-43 2 5 Pfam Pfam NNP en-wikipedia-org-43 2 6 PF00243 PF00243 NNP en-wikipedia-org-43 2 7 InterPro InterPro NNP en-wikipedia-org-43 2 8 IPR002072 IPR002072 NNP en-wikipedia-org-43 2 9 PROSITE PROSITE NNP en-wikipedia-org-43 2 10 PDOC00221 PDOC00221 NNP en-wikipedia-org-43 2 11 SCOP2 SCOP2 NNP en-wikipedia-org-43 2 12 1bet 1bet NNP en-wikipedia-org-43 2 13 / / SYM en-wikipedia-org-43 2 14 SCOPe SCOPe NNP en-wikipedia-org-43 2 15 / / SYM en-wikipedia-org-43 2 16 SUPFAM SUPFAM NNP en-wikipedia-org-43 2 17 Available available JJ en-wikipedia-org-43 2 18 protein protein NN en-wikipedia-org-43 2 19 structures structure NNS en-wikipedia-org-43 2 20 : : : en-wikipedia-org-43 2 21 Pfam pfam NN en-wikipedia-org-43 2 22     _SP en-wikipedia-org-43 2 23 structures structure NNS en-wikipedia-org-43 2 24 / / SYM en-wikipedia-org-43 2 25 ECOD ECOD NNP en-wikipedia-org-43 2 26     _SP en-wikipedia-org-43 2 27 PDB PDB NNP en-wikipedia-org-43 2 28 RCSB RCSB NNS en-wikipedia-org-43 2 29 PDB pdb NN en-wikipedia-org-43 2 30 ; ; : en-wikipedia-org-43 2 31 PDBe PDBe NNS en-wikipedia-org-43 2 32 ; ; : en-wikipedia-org-43 2 33 PDBj PDBj NNS en-wikipedia-org-43 2 34 PDBsum pdbsum NN en-wikipedia-org-43 2 35 structure structure NN en-wikipedia-org-43 2 36 summary summary NN en-wikipedia-org-43 2 37 Neurotrophins neurotrophin NNS en-wikipedia-org-43 2 38 are be VBP en-wikipedia-org-43 2 39 a a DT en-wikipedia-org-43 2 40 family family NN en-wikipedia-org-43 2 41 of of IN en-wikipedia-org-43 2 42 proteins protein NNS en-wikipedia-org-43 2 43 that that WDT en-wikipedia-org-43 2 44 induce induce VBP en-wikipedia-org-43 2 45 the the DT en-wikipedia-org-43 2 46 survival,[1 survival,[1 NN en-wikipedia-org-43 2 47 ] ] -RRB- en-wikipedia-org-43 2 48 development development NN en-wikipedia-org-43 2 49 , , , en-wikipedia-org-43 2 50 and and CC en-wikipedia-org-43 2 51 function[2 function[2 JJ en-wikipedia-org-43 2 52 ] ] -RRB- en-wikipedia-org-43 2 53 of of IN en-wikipedia-org-43 2 54 neurons neuron NNS en-wikipedia-org-43 2 55 . . . en-wikipedia-org-43 3 1 They -PRON- PRP en-wikipedia-org-43 3 2 belong belong VBP en-wikipedia-org-43 3 3 to to IN en-wikipedia-org-43 3 4 a a DT en-wikipedia-org-43 3 5 class class NN en-wikipedia-org-43 3 6 of of IN en-wikipedia-org-43 3 7 growth growth NN en-wikipedia-org-43 3 8 factors factor NNS en-wikipedia-org-43 3 9 , , , en-wikipedia-org-43 3 10 secreted secrete VBD en-wikipedia-org-43 3 11 proteins protein NNS en-wikipedia-org-43 3 12 that that WDT en-wikipedia-org-43 3 13 can can MD en-wikipedia-org-43 3 14 signal signal VB en-wikipedia-org-43 3 15 particular particular JJ en-wikipedia-org-43 3 16 cells cell NNS en-wikipedia-org-43 3 17 to to TO en-wikipedia-org-43 3 18 survive survive VB en-wikipedia-org-43 3 19 , , , en-wikipedia-org-43 3 20 differentiate differentiate JJ en-wikipedia-org-43 3 21 , , , en-wikipedia-org-43 3 22 or or CC en-wikipedia-org-43 3 23 grow grow VB en-wikipedia-org-43 3 24 . . . en-wikipedia-org-43 4 1 [ [ -LRB- en-wikipedia-org-43 4 2 3 3 LS en-wikipedia-org-43 4 3 ] ] -RRB- en-wikipedia-org-43 4 4 Growth growth NN en-wikipedia-org-43 4 5 factors factor NNS en-wikipedia-org-43 4 6 such such JJ en-wikipedia-org-43 4 7 as as IN en-wikipedia-org-43 4 8 neurotrophins neurotrophin NNS en-wikipedia-org-43 4 9 that that WDT en-wikipedia-org-43 4 10 promote promote VBP en-wikipedia-org-43 4 11 the the DT en-wikipedia-org-43 4 12 survival survival NN en-wikipedia-org-43 4 13 of of IN en-wikipedia-org-43 4 14 neurons neuron NNS en-wikipedia-org-43 4 15 are be VBP en-wikipedia-org-43 4 16 known know VBN en-wikipedia-org-43 4 17 as as IN en-wikipedia-org-43 4 18 neurotrophic neurotrophic JJ en-wikipedia-org-43 4 19 factors factor NNS en-wikipedia-org-43 4 20 . . . en-wikipedia-org-43 5 1 Neurotrophic neurotrophic JJ en-wikipedia-org-43 5 2 factors factor NNS en-wikipedia-org-43 5 3 are be VBP en-wikipedia-org-43 5 4 secreted secrete VBN en-wikipedia-org-43 5 5 by by IN en-wikipedia-org-43 5 6 target target NN en-wikipedia-org-43 5 7 tissue tissue NN en-wikipedia-org-43 5 8 and and CC en-wikipedia-org-43 5 9 act act NN en-wikipedia-org-43 5 10 by by IN en-wikipedia-org-43 5 11 preventing prevent VBG en-wikipedia-org-43 5 12 the the DT en-wikipedia-org-43 5 13 associated associate VBN en-wikipedia-org-43 5 14 neuron neuron NNP en-wikipedia-org-43 5 15 from from IN en-wikipedia-org-43 5 16 initiating initiate VBG en-wikipedia-org-43 5 17 programmed program VBN en-wikipedia-org-43 5 18 cell cell NN en-wikipedia-org-43 5 19 death death NN en-wikipedia-org-43 5 20 – – : en-wikipedia-org-43 5 21 allowing allow VBG en-wikipedia-org-43 5 22 the the DT en-wikipedia-org-43 5 23 neurons neuron NNS en-wikipedia-org-43 5 24 to to TO en-wikipedia-org-43 5 25 survive survive VB en-wikipedia-org-43 5 26 . . . en-wikipedia-org-43 6 1 Neurotrophins neurotrophin NNS en-wikipedia-org-43 6 2 also also RB en-wikipedia-org-43 6 3 induce induce VBP en-wikipedia-org-43 6 4 differentiation differentiation NN en-wikipedia-org-43 6 5 of of IN en-wikipedia-org-43 6 6 progenitor progenitor NN en-wikipedia-org-43 6 7 cells cell NNS en-wikipedia-org-43 6 8 , , , en-wikipedia-org-43 6 9 to to TO en-wikipedia-org-43 6 10 form form VB en-wikipedia-org-43 6 11 neurons neuron NNS en-wikipedia-org-43 6 12 . . . en-wikipedia-org-43 7 1 Although although IN en-wikipedia-org-43 7 2 the the DT en-wikipedia-org-43 7 3 vast vast JJ en-wikipedia-org-43 7 4 majority majority NN en-wikipedia-org-43 7 5 of of IN en-wikipedia-org-43 7 6 neurons neuron NNS en-wikipedia-org-43 7 7 in in IN en-wikipedia-org-43 7 8 the the DT en-wikipedia-org-43 7 9 mammalian mammalian JJ en-wikipedia-org-43 7 10 brain brain NN en-wikipedia-org-43 7 11 are be VBP en-wikipedia-org-43 7 12 formed form VBN en-wikipedia-org-43 7 13 prenatally prenatally RB en-wikipedia-org-43 7 14 , , , en-wikipedia-org-43 7 15 parts part NNS en-wikipedia-org-43 7 16 of of IN en-wikipedia-org-43 7 17 the the DT en-wikipedia-org-43 7 18 adult adult NN en-wikipedia-org-43 7 19 brain brain NN en-wikipedia-org-43 7 20 ( ( -LRB- en-wikipedia-org-43 7 21 for for IN en-wikipedia-org-43 7 22 example example NN en-wikipedia-org-43 7 23 , , , en-wikipedia-org-43 7 24 the the DT en-wikipedia-org-43 7 25 hippocampus hippocampus NN en-wikipedia-org-43 7 26 ) ) -RRB- en-wikipedia-org-43 7 27 retain retain VB en-wikipedia-org-43 7 28 the the DT en-wikipedia-org-43 7 29 ability ability NN en-wikipedia-org-43 7 30 to to TO en-wikipedia-org-43 7 31 grow grow VB en-wikipedia-org-43 7 32 new new JJ en-wikipedia-org-43 7 33 neurons neuron NNS en-wikipedia-org-43 7 34 from from IN en-wikipedia-org-43 7 35 neural neural JJ en-wikipedia-org-43 7 36 stem stem NN en-wikipedia-org-43 7 37 cells cell NNS en-wikipedia-org-43 7 38 , , , en-wikipedia-org-43 7 39 a a DT en-wikipedia-org-43 7 40 process process NN en-wikipedia-org-43 7 41 known know VBN en-wikipedia-org-43 7 42 as as IN en-wikipedia-org-43 7 43 neurogenesis neurogenesis NN en-wikipedia-org-43 7 44 . . . en-wikipedia-org-43 8 1 [ [ -LRB- en-wikipedia-org-43 8 2 4 4 LS en-wikipedia-org-43 8 3 ] ] -RRB- en-wikipedia-org-43 8 4 Neurotrophins neurotrophin NNS en-wikipedia-org-43 8 5 are be VBP en-wikipedia-org-43 8 6 chemicals chemical NNS en-wikipedia-org-43 8 7 that that WDT en-wikipedia-org-43 8 8 help help VBP en-wikipedia-org-43 8 9 to to TO en-wikipedia-org-43 8 10 stimulate stimulate VB en-wikipedia-org-43 8 11 and and CC en-wikipedia-org-43 8 12 control control VB en-wikipedia-org-43 8 13 neurogenesis neurogenesis NN en-wikipedia-org-43 8 14 . . . en-wikipedia-org-43 9 1 Contents content NNS en-wikipedia-org-43 9 2 1 1 CD en-wikipedia-org-43 9 3 Terminology terminology NN en-wikipedia-org-43 9 4 2 2 CD en-wikipedia-org-43 9 5 Function function NN en-wikipedia-org-43 9 6 3 3 CD en-wikipedia-org-43 9 7 Receptors Receptors NNPS en-wikipedia-org-43 9 8 4 4 CD en-wikipedia-org-43 9 9 Types type NNS en-wikipedia-org-43 9 10 4.1 4.1 CD en-wikipedia-org-43 9 11 Nerve Nerve NNP en-wikipedia-org-43 9 12 growth growth NN en-wikipedia-org-43 9 13 factor factor NN en-wikipedia-org-43 9 14 4.2 4.2 CD en-wikipedia-org-43 9 15 Brain brain NN en-wikipedia-org-43 9 16 - - HYPH en-wikipedia-org-43 9 17 derived derive VBN en-wikipedia-org-43 9 18 neurotrophic neurotrophic JJ en-wikipedia-org-43 9 19 factor factor NN en-wikipedia-org-43 9 20 4.3 4.3 CD en-wikipedia-org-43 9 21 Neurotrophin-3 Neurotrophin-3 NNP en-wikipedia-org-43 9 22 4.4 4.4 CD en-wikipedia-org-43 9 23 Neurotrophin-4 Neurotrophin-4 NNP en-wikipedia-org-43 9 24 4.5 4.5 CD en-wikipedia-org-43 9 25 DHEA dhea NN en-wikipedia-org-43 9 26 and and CC en-wikipedia-org-43 9 27 DHEA dhea NN en-wikipedia-org-43 9 28 sulfate sulfate VBP en-wikipedia-org-43 9 29 5 5 CD en-wikipedia-org-43 9 30 Role role NN en-wikipedia-org-43 9 31 in in IN en-wikipedia-org-43 9 32 programmed program VBN en-wikipedia-org-43 9 33 cell cell NN en-wikipedia-org-43 9 34 death death NN en-wikipedia-org-43 9 35 6 6 CD en-wikipedia-org-43 9 36 See see VBP en-wikipedia-org-43 9 37 also also RB en-wikipedia-org-43 9 38 7 7 CD en-wikipedia-org-43 9 39 References reference NNS en-wikipedia-org-43 9 40 8 8 CD en-wikipedia-org-43 9 41 External external JJ en-wikipedia-org-43 9 42 links link NNS en-wikipedia-org-43 9 43 Terminology[edit Terminology[edit '' en-wikipedia-org-43 9 44 ] ] -RRB- en-wikipedia-org-43 9 45 According accord VBG en-wikipedia-org-43 9 46 to to IN en-wikipedia-org-43 9 47 the the DT en-wikipedia-org-43 9 48 United United NNP en-wikipedia-org-43 9 49 States States NNP en-wikipedia-org-43 9 50 National National NNP en-wikipedia-org-43 9 51 Library Library NNP en-wikipedia-org-43 9 52 of of IN en-wikipedia-org-43 9 53 Medicine Medicine NNP en-wikipedia-org-43 9 54 's 's POS en-wikipedia-org-43 9 55 medical medical JJ en-wikipedia-org-43 9 56 subject subject JJ en-wikipedia-org-43 9 57 headings heading NNS en-wikipedia-org-43 9 58 , , , en-wikipedia-org-43 9 59 the the DT en-wikipedia-org-43 9 60 term term NN en-wikipedia-org-43 9 61 neurotrophin neurotrophin NN en-wikipedia-org-43 9 62 may may MD en-wikipedia-org-43 9 63 be be VB en-wikipedia-org-43 9 64 used use VBN en-wikipedia-org-43 9 65 as as IN en-wikipedia-org-43 9 66 a a DT en-wikipedia-org-43 9 67 synonym synonym NN en-wikipedia-org-43 9 68 for for IN en-wikipedia-org-43 9 69 neurotrophic neurotrophic JJ en-wikipedia-org-43 9 70 factor,[5 factor,[5 , en-wikipedia-org-43 9 71 ] ] -RRB- en-wikipedia-org-43 9 72 but but CC en-wikipedia-org-43 9 73 the the DT en-wikipedia-org-43 9 74 term term NN en-wikipedia-org-43 9 75 neurotrophin neurotrophin NN en-wikipedia-org-43 9 76 is be VBZ en-wikipedia-org-43 9 77 more more RBR en-wikipedia-org-43 9 78 generally generally RB en-wikipedia-org-43 9 79 reserved reserve VBN en-wikipedia-org-43 9 80 for for IN en-wikipedia-org-43 9 81 four four CD en-wikipedia-org-43 9 82 structurally structurally RB en-wikipedia-org-43 9 83 related relate VBN en-wikipedia-org-43 9 84 factors factor NNS en-wikipedia-org-43 9 85 : : : en-wikipedia-org-43 9 86 nerve nerve NN en-wikipedia-org-43 9 87 growth growth NN en-wikipedia-org-43 9 88 factor factor NN en-wikipedia-org-43 9 89 ( ( -LRB- en-wikipedia-org-43 9 90 NGF NGF NNP en-wikipedia-org-43 9 91 ) ) -RRB- en-wikipedia-org-43 9 92 , , , en-wikipedia-org-43 9 93 brain brain NN en-wikipedia-org-43 9 94 - - HYPH en-wikipedia-org-43 9 95 derived derive VBN en-wikipedia-org-43 9 96 neurotrophic neurotrophic JJ en-wikipedia-org-43 9 97 factor factor NN en-wikipedia-org-43 9 98 ( ( -LRB- en-wikipedia-org-43 9 99 BDNF BDNF NNP en-wikipedia-org-43 9 100 ) ) -RRB- en-wikipedia-org-43 9 101 , , , en-wikipedia-org-43 9 102 neurotrophin-3 neurotrophin-3 NNP en-wikipedia-org-43 9 103 ( ( -LRB- en-wikipedia-org-43 9 104 NT-3 NT-3 NNP en-wikipedia-org-43 9 105 ) ) -RRB- en-wikipedia-org-43 9 106 , , , en-wikipedia-org-43 9 107 and and CC en-wikipedia-org-43 9 108 neurotrophin-4 neurotrophin-4 NNP en-wikipedia-org-43 9 109 ( ( -LRB- en-wikipedia-org-43 9 110 NT-4 NT-4 NNP en-wikipedia-org-43 9 111 ) ) -RRB- en-wikipedia-org-43 9 112 . . . en-wikipedia-org-43 10 1 [ [ -LRB- en-wikipedia-org-43 10 2 6 6 CD en-wikipedia-org-43 10 3 ] ] -RRB- en-wikipedia-org-43 10 4 The the DT en-wikipedia-org-43 10 5 term term NN en-wikipedia-org-43 10 6 neurotrophic neurotrophic JJ en-wikipedia-org-43 10 7 factor factor NN en-wikipedia-org-43 10 8 generally generally RB en-wikipedia-org-43 10 9 refers refer VBZ en-wikipedia-org-43 10 10 to to IN en-wikipedia-org-43 10 11 these these DT en-wikipedia-org-43 10 12 four four CD en-wikipedia-org-43 10 13 neurotrophins neurotrophin NNS en-wikipedia-org-43 10 14 , , , en-wikipedia-org-43 10 15 the the DT en-wikipedia-org-43 10 16 GDNF GDNF NNP en-wikipedia-org-43 10 17 family family NN en-wikipedia-org-43 10 18 of of IN en-wikipedia-org-43 10 19 ligands ligand NNS en-wikipedia-org-43 10 20 , , , en-wikipedia-org-43 10 21 and and CC en-wikipedia-org-43 10 22 ciliary ciliary JJ en-wikipedia-org-43 10 23 neurotrophic neurotrophic JJ en-wikipedia-org-43 10 24 factor factor NN en-wikipedia-org-43 10 25 ( ( -LRB- en-wikipedia-org-43 10 26 CNTF CNTF NNP en-wikipedia-org-43 10 27 ) ) -RRB- en-wikipedia-org-43 10 28 , , , en-wikipedia-org-43 10 29 among among IN en-wikipedia-org-43 10 30 other other JJ en-wikipedia-org-43 10 31 biomolecules biomolecule NNS en-wikipedia-org-43 10 32 . . . en-wikipedia-org-43 11 1 [ [ -LRB- en-wikipedia-org-43 11 2 6][7 6][7 NNP en-wikipedia-org-43 11 3 ] ] -RRB- en-wikipedia-org-43 11 4 Neurotrophin-6 Neurotrophin-6 NNP en-wikipedia-org-43 11 5 and and CC en-wikipedia-org-43 11 6 neurotrophin-7 neurotrophin-7 NNP en-wikipedia-org-43 11 7 also also RB en-wikipedia-org-43 11 8 exist exist VBP en-wikipedia-org-43 11 9 but but CC en-wikipedia-org-43 11 10 are be VBP en-wikipedia-org-43 11 11 only only RB en-wikipedia-org-43 11 12 found find VBN en-wikipedia-org-43 11 13 in in IN en-wikipedia-org-43 11 14 zebrafish zebrafish NNP en-wikipedia-org-43 11 15 . . . en-wikipedia-org-43 12 1 [ [ -LRB- en-wikipedia-org-43 12 2 8 8 CD en-wikipedia-org-43 12 3 ] ] -RRB- en-wikipedia-org-43 12 4 Function[edit function[edit CD en-wikipedia-org-43 12 5 ] ] -RRB- en-wikipedia-org-43 12 6 During during IN en-wikipedia-org-43 12 7 the the DT en-wikipedia-org-43 12 8 development development NN en-wikipedia-org-43 12 9 of of IN en-wikipedia-org-43 12 10 the the DT en-wikipedia-org-43 12 11 vertebrate vertebrate JJ en-wikipedia-org-43 12 12 nervous nervous JJ en-wikipedia-org-43 12 13 system system NN en-wikipedia-org-43 12 14 , , , en-wikipedia-org-43 12 15 many many JJ en-wikipedia-org-43 12 16 neurons neuron NNS en-wikipedia-org-43 12 17 become become VBP en-wikipedia-org-43 12 18 redundant redundant JJ en-wikipedia-org-43 12 19 ( ( -LRB- en-wikipedia-org-43 12 20 because because IN en-wikipedia-org-43 12 21 they -PRON- PRP en-wikipedia-org-43 12 22 have have VBP en-wikipedia-org-43 12 23 died die VBN en-wikipedia-org-43 12 24 , , , en-wikipedia-org-43 12 25 failed fail VBD en-wikipedia-org-43 12 26 to to TO en-wikipedia-org-43 12 27 connect connect VB en-wikipedia-org-43 12 28 to to TO en-wikipedia-org-43 12 29 target target VB en-wikipedia-org-43 12 30 cells cell NNS en-wikipedia-org-43 12 31 , , , en-wikipedia-org-43 12 32 etc etc FW en-wikipedia-org-43 12 33 . . . en-wikipedia-org-43 12 34 ) ) -RRB- en-wikipedia-org-43 13 1 and and CC en-wikipedia-org-43 13 2 are be VBP en-wikipedia-org-43 13 3 eliminated eliminate VBN en-wikipedia-org-43 13 4 . . . en-wikipedia-org-43 14 1 At at IN en-wikipedia-org-43 14 2 the the DT en-wikipedia-org-43 14 3 same same JJ en-wikipedia-org-43 14 4 time time NN en-wikipedia-org-43 14 5 , , , en-wikipedia-org-43 14 6 developing develop VBG en-wikipedia-org-43 14 7 neurons neuron NNS en-wikipedia-org-43 14 8 send send VBP en-wikipedia-org-43 14 9 out out RP en-wikipedia-org-43 14 10 axon axon NNS en-wikipedia-org-43 14 11 outgrowths outgrowth NNS en-wikipedia-org-43 14 12 that that WDT en-wikipedia-org-43 14 13 contact contact VBP en-wikipedia-org-43 14 14 their -PRON- PRP$ en-wikipedia-org-43 14 15 target target NN en-wikipedia-org-43 14 16 cells cell NNS en-wikipedia-org-43 14 17 . . . en-wikipedia-org-43 15 1 [ [ -LRB- en-wikipedia-org-43 15 2 9 9 CD en-wikipedia-org-43 15 3 ] ] -RRB- en-wikipedia-org-43 15 4 Such such JJ en-wikipedia-org-43 15 5 cells cell NNS en-wikipedia-org-43 15 6 control control VBP en-wikipedia-org-43 15 7 their -PRON- PRP$ en-wikipedia-org-43 15 8 degree degree NN en-wikipedia-org-43 15 9 of of IN en-wikipedia-org-43 15 10 innervation innervation NN en-wikipedia-org-43 15 11 ( ( -LRB- en-wikipedia-org-43 15 12 the the DT en-wikipedia-org-43 15 13 number number NN en-wikipedia-org-43 15 14 of of IN en-wikipedia-org-43 15 15 axon axon NNP en-wikipedia-org-43 15 16 connections connection NNS en-wikipedia-org-43 15 17 ) ) -RRB- en-wikipedia-org-43 15 18 by by IN en-wikipedia-org-43 15 19 the the DT en-wikipedia-org-43 15 20 secretion secretion NN en-wikipedia-org-43 15 21 of of IN en-wikipedia-org-43 15 22 various various JJ en-wikipedia-org-43 15 23 specific specific JJ en-wikipedia-org-43 15 24 neurotrophic neurotrophic JJ en-wikipedia-org-43 15 25 factors factor NNS en-wikipedia-org-43 15 26 that that WDT en-wikipedia-org-43 15 27 are be VBP en-wikipedia-org-43 15 28 essential essential JJ en-wikipedia-org-43 15 29 for for IN en-wikipedia-org-43 15 30 neuron neuron NNP en-wikipedia-org-43 15 31 survival survival NN en-wikipedia-org-43 15 32 . . . en-wikipedia-org-43 16 1 One one CD en-wikipedia-org-43 16 2 of of IN en-wikipedia-org-43 16 3 these these DT en-wikipedia-org-43 16 4 is be VBZ en-wikipedia-org-43 16 5 nerve nerve NN en-wikipedia-org-43 16 6 growth growth NN en-wikipedia-org-43 16 7 factor factor NN en-wikipedia-org-43 16 8 ( ( -LRB- en-wikipedia-org-43 16 9 NGF NGF NNP en-wikipedia-org-43 16 10 or or CC en-wikipedia-org-43 16 11 beta beta NNP en-wikipedia-org-43 16 12 - - HYPH en-wikipedia-org-43 16 13 NGF NGF NNP en-wikipedia-org-43 16 14 ) ) -RRB- en-wikipedia-org-43 16 15 , , , en-wikipedia-org-43 16 16 a a DT en-wikipedia-org-43 16 17 vertebrate vertebrate JJ en-wikipedia-org-43 16 18 protein protein NN en-wikipedia-org-43 16 19 that that WDT en-wikipedia-org-43 16 20 stimulates stimulate VBZ en-wikipedia-org-43 16 21 division division NN en-wikipedia-org-43 16 22 and and CC en-wikipedia-org-43 16 23 differentiation differentiation NN en-wikipedia-org-43 16 24 of of IN en-wikipedia-org-43 16 25 sympathetic sympathetic JJ en-wikipedia-org-43 16 26 and and CC en-wikipedia-org-43 16 27 embryonic embryonic JJ en-wikipedia-org-43 16 28 sensory sensory JJ en-wikipedia-org-43 16 29 neurons neuron NNS en-wikipedia-org-43 16 30 . . . en-wikipedia-org-43 17 1 [ [ -LRB- en-wikipedia-org-43 17 2 10][11 10][11 CD en-wikipedia-org-43 17 3 ] ] -RRB- en-wikipedia-org-43 17 4 NGF NGF NNP en-wikipedia-org-43 17 5 is be VBZ en-wikipedia-org-43 17 6 mostly mostly RB en-wikipedia-org-43 17 7 found find VBN en-wikipedia-org-43 17 8 outside outside IN en-wikipedia-org-43 17 9 the the DT en-wikipedia-org-43 17 10 central central JJ en-wikipedia-org-43 17 11 nervous nervous JJ en-wikipedia-org-43 17 12 system system NN en-wikipedia-org-43 17 13 ( ( -LRB- en-wikipedia-org-43 17 14 CNS CNS NNP en-wikipedia-org-43 17 15 ) ) -RRB- en-wikipedia-org-43 17 16 , , , en-wikipedia-org-43 17 17 but but CC en-wikipedia-org-43 17 18 slight slight JJ en-wikipedia-org-43 17 19 traces trace NNS en-wikipedia-org-43 17 20 have have VBP en-wikipedia-org-43 17 21 been be VBN en-wikipedia-org-43 17 22 detected detect VBN en-wikipedia-org-43 17 23 in in IN en-wikipedia-org-43 17 24 adult adult NN en-wikipedia-org-43 17 25 CNS CNS NNP en-wikipedia-org-43 17 26 tissues tissue NNS en-wikipedia-org-43 17 27 , , , en-wikipedia-org-43 17 28 although although IN en-wikipedia-org-43 17 29 a a DT en-wikipedia-org-43 17 30 physiological physiological JJ en-wikipedia-org-43 17 31 role role NN en-wikipedia-org-43 17 32 for for IN en-wikipedia-org-43 17 33 this this DT en-wikipedia-org-43 17 34 is be VBZ en-wikipedia-org-43 17 35 unknown unknown JJ en-wikipedia-org-43 17 36 . . . en-wikipedia-org-43 18 1 [ [ -LRB- en-wikipedia-org-43 18 2 9 9 CD en-wikipedia-org-43 18 3 ] ] -RRB- en-wikipedia-org-43 18 4 It -PRON- PRP en-wikipedia-org-43 18 5 has have VBZ en-wikipedia-org-43 18 6 also also RB en-wikipedia-org-43 18 7 been be VBN en-wikipedia-org-43 18 8 found find VBN en-wikipedia-org-43 18 9 in in IN en-wikipedia-org-43 18 10 several several JJ en-wikipedia-org-43 18 11 snake snake NN en-wikipedia-org-43 18 12 venoms venom NNS en-wikipedia-org-43 18 13 . . . en-wikipedia-org-43 19 1 [ [ -LRB- en-wikipedia-org-43 19 2 12][13 12][13 CD en-wikipedia-org-43 19 3 ] ] -RRB- en-wikipedia-org-43 19 4 In in IN en-wikipedia-org-43 19 5 the the DT en-wikipedia-org-43 19 6 peripheral peripheral JJ en-wikipedia-org-43 19 7 and and CC en-wikipedia-org-43 19 8 central central JJ en-wikipedia-org-43 19 9 neurons neuron NNS en-wikipedia-org-43 19 10 , , , en-wikipedia-org-43 19 11 neurotrophins neurotrophin NNS en-wikipedia-org-43 19 12 are be VBP en-wikipedia-org-43 19 13 important important JJ en-wikipedia-org-43 19 14 regulators regulator NNS en-wikipedia-org-43 19 15 for for IN en-wikipedia-org-43 19 16 survival survival NN en-wikipedia-org-43 19 17 , , , en-wikipedia-org-43 19 18 differentiation differentiation NN en-wikipedia-org-43 19 19 , , , en-wikipedia-org-43 19 20 and and CC en-wikipedia-org-43 19 21 maintenance maintenance NN en-wikipedia-org-43 19 22 of of IN en-wikipedia-org-43 19 23 nerve nerve NN en-wikipedia-org-43 19 24 cells cell NNS en-wikipedia-org-43 19 25 . . . en-wikipedia-org-43 20 1 They -PRON- PRP en-wikipedia-org-43 20 2 are be VBP en-wikipedia-org-43 20 3 small small JJ en-wikipedia-org-43 20 4 proteins protein NNS en-wikipedia-org-43 20 5 that that WDT en-wikipedia-org-43 20 6 secrete secrete VBP en-wikipedia-org-43 20 7 into into IN en-wikipedia-org-43 20 8 the the DT en-wikipedia-org-43 20 9 nervous nervous JJ en-wikipedia-org-43 20 10 system system NN en-wikipedia-org-43 20 11 to to TO en-wikipedia-org-43 20 12 help help VB en-wikipedia-org-43 20 13 keep keep VB en-wikipedia-org-43 20 14 nerve nerve NN en-wikipedia-org-43 20 15 cells cell NNS en-wikipedia-org-43 20 16 alive alive JJ en-wikipedia-org-43 20 17 . . . en-wikipedia-org-43 21 1 There there EX en-wikipedia-org-43 21 2 are be VBP en-wikipedia-org-43 21 3 two two CD en-wikipedia-org-43 21 4 distinct distinct JJ en-wikipedia-org-43 21 5 classes class NNS en-wikipedia-org-43 21 6 of of IN en-wikipedia-org-43 21 7 glycosylated glycosylate VBN en-wikipedia-org-43 21 8 receptors receptor NNS en-wikipedia-org-43 21 9 that that WDT en-wikipedia-org-43 21 10 can can MD en-wikipedia-org-43 21 11 bind bind VB en-wikipedia-org-43 21 12 to to IN en-wikipedia-org-43 21 13 neurotrophins neurotrophin NNS en-wikipedia-org-43 21 14 . . . en-wikipedia-org-43 22 1 These these DT en-wikipedia-org-43 22 2 two two CD en-wikipedia-org-43 22 3 proteins protein NNS en-wikipedia-org-43 22 4 are be VBP en-wikipedia-org-43 22 5 p75 p75 CD en-wikipedia-org-43 22 6 ( ( -LRB- en-wikipedia-org-43 22 7 NTR NTR NNP en-wikipedia-org-43 22 8 ) ) -RRB- en-wikipedia-org-43 22 9 , , , en-wikipedia-org-43 22 10 which which WDT en-wikipedia-org-43 22 11 binds bind VBZ en-wikipedia-org-43 22 12 to to IN en-wikipedia-org-43 22 13 all all DT en-wikipedia-org-43 22 14 neurotrophins neurotrophin NNS en-wikipedia-org-43 22 15 , , , en-wikipedia-org-43 22 16 and and CC en-wikipedia-org-43 22 17 subtypes subtype NNS en-wikipedia-org-43 22 18 of of IN en-wikipedia-org-43 22 19 Trk Trk NNP en-wikipedia-org-43 22 20 , , , en-wikipedia-org-43 22 21 which which WDT en-wikipedia-org-43 22 22 are be VBP en-wikipedia-org-43 22 23 each each DT en-wikipedia-org-43 22 24 specific specific JJ en-wikipedia-org-43 22 25 for for IN en-wikipedia-org-43 22 26 different different JJ en-wikipedia-org-43 22 27 neurotrophins neurotrophin NNS en-wikipedia-org-43 22 28 . . . en-wikipedia-org-43 23 1 The the DT en-wikipedia-org-43 23 2 reported report VBN en-wikipedia-org-43 23 3 structure structure NN en-wikipedia-org-43 23 4 above above RB en-wikipedia-org-43 23 5 is be VBZ en-wikipedia-org-43 23 6 a a DT en-wikipedia-org-43 23 7 2.6 2.6 CD en-wikipedia-org-43 23 8 Å Å NNP en-wikipedia-org-43 23 9 - - HYPH en-wikipedia-org-43 23 10 resolution resolution NN en-wikipedia-org-43 23 11 crystal crystal NN en-wikipedia-org-43 23 12 structure structure NN en-wikipedia-org-43 23 13 of of IN en-wikipedia-org-43 23 14 neurotrophin-3 neurotrophin-3 NNP en-wikipedia-org-43 23 15 ( ( -LRB- en-wikipedia-org-43 23 16 NT-3 NT-3 NNP en-wikipedia-org-43 23 17 ) ) -RRB- en-wikipedia-org-43 23 18 complexed complexe VBD en-wikipedia-org-43 23 19 to to IN en-wikipedia-org-43 23 20 the the DT en-wikipedia-org-43 23 21 ectodomain ectodomain NN en-wikipedia-org-43 23 22 of of IN en-wikipedia-org-43 23 23 glycosylated glycosylate VBN en-wikipedia-org-43 23 24 p75 p75 NN en-wikipedia-org-43 23 25 ( ( -LRB- en-wikipedia-org-43 23 26 NRT NRT NNP en-wikipedia-org-43 23 27 ) ) -RRB- en-wikipedia-org-43 23 28 , , , en-wikipedia-org-43 23 29 forming form VBG en-wikipedia-org-43 23 30 a a DT en-wikipedia-org-43 23 31 symmetrical symmetrical JJ en-wikipedia-org-43 23 32 crystal crystal NN en-wikipedia-org-43 23 33 structure structure NN en-wikipedia-org-43 23 34 . . . en-wikipedia-org-43 24 1 Receptors[edit receptors[edit LS en-wikipedia-org-43 24 2 ] ] -RRB- en-wikipedia-org-43 24 3 Main main JJ en-wikipedia-org-43 24 4 article article NN en-wikipedia-org-43 24 5 : : : en-wikipedia-org-43 24 6 Nerve nerve NN en-wikipedia-org-43 24 7 growth growth NN en-wikipedia-org-43 24 8 factor factor NN en-wikipedia-org-43 24 9 receptor receptor NN en-wikipedia-org-43 24 10 There there EX en-wikipedia-org-43 24 11 are be VBP en-wikipedia-org-43 24 12 two two CD en-wikipedia-org-43 24 13 classes class NNS en-wikipedia-org-43 24 14 of of IN en-wikipedia-org-43 24 15 receptors receptor NNS en-wikipedia-org-43 24 16 for for IN en-wikipedia-org-43 24 17 neurotrophins neurotrophin NNS en-wikipedia-org-43 24 18 : : : en-wikipedia-org-43 24 19 p75 p75 NNP en-wikipedia-org-43 24 20 and and CC en-wikipedia-org-43 24 21 the the DT en-wikipedia-org-43 24 22 " " `` en-wikipedia-org-43 24 23 Trk Trk NNP en-wikipedia-org-43 24 24 " " '' en-wikipedia-org-43 24 25 family family NN en-wikipedia-org-43 24 26 of of IN en-wikipedia-org-43 24 27 Tyrosine Tyrosine NNP en-wikipedia-org-43 24 28 kinases kinase NNS en-wikipedia-org-43 24 29 receptors receptor NNS en-wikipedia-org-43 24 30 . . . en-wikipedia-org-43 25 1 [ [ -LRB- en-wikipedia-org-43 25 2 14 14 CD en-wikipedia-org-43 25 3 ] ] -RRB- en-wikipedia-org-43 25 4 Types[edit types[edit NN en-wikipedia-org-43 25 5 ] ] -RRB- en-wikipedia-org-43 25 6 Nerve nerve NN en-wikipedia-org-43 25 7 growth growth NN en-wikipedia-org-43 25 8 factor[edit factor[edit NFP en-wikipedia-org-43 25 9 ] ] -RRB- en-wikipedia-org-43 25 10 Main main JJ en-wikipedia-org-43 25 11 article article NN en-wikipedia-org-43 25 12 : : : en-wikipedia-org-43 25 13 Nerve nerve NN en-wikipedia-org-43 25 14 growth growth NN en-wikipedia-org-43 25 15 factor factor NN en-wikipedia-org-43 25 16 Nerve Nerve NNP en-wikipedia-org-43 25 17 growth growth NN en-wikipedia-org-43 25 18 factor factor NN en-wikipedia-org-43 25 19 ( ( -LRB- en-wikipedia-org-43 25 20 NGF NGF NNP en-wikipedia-org-43 25 21 ) ) -RRB- en-wikipedia-org-43 25 22 , , , en-wikipedia-org-43 25 23 the the DT en-wikipedia-org-43 25 24 prototypical prototypical JJ en-wikipedia-org-43 25 25 growth growth NN en-wikipedia-org-43 25 26 factor factor NN en-wikipedia-org-43 25 27 , , , en-wikipedia-org-43 25 28 is be VBZ en-wikipedia-org-43 25 29 a a DT en-wikipedia-org-43 25 30 protein protein NN en-wikipedia-org-43 25 31 secreted secrete VBN en-wikipedia-org-43 25 32 by by IN en-wikipedia-org-43 25 33 a a DT en-wikipedia-org-43 25 34 neuron neuron NN en-wikipedia-org-43 25 35 's 's POS en-wikipedia-org-43 25 36 target target NN en-wikipedia-org-43 25 37 cell cell NN en-wikipedia-org-43 25 38 . . . en-wikipedia-org-43 26 1 NGF NGF NNP en-wikipedia-org-43 26 2 is be VBZ en-wikipedia-org-43 26 3 critical critical JJ en-wikipedia-org-43 26 4 for for IN en-wikipedia-org-43 26 5 the the DT en-wikipedia-org-43 26 6 survival survival NN en-wikipedia-org-43 26 7 and and CC en-wikipedia-org-43 26 8 maintenance maintenance NN en-wikipedia-org-43 26 9 of of IN en-wikipedia-org-43 26 10 sympathetic sympathetic JJ en-wikipedia-org-43 26 11 and and CC en-wikipedia-org-43 26 12 sensory sensory JJ en-wikipedia-org-43 26 13 neurons neuron NNS en-wikipedia-org-43 26 14 . . . en-wikipedia-org-43 27 1 NGF NGF NNP en-wikipedia-org-43 27 2 is be VBZ en-wikipedia-org-43 27 3 released release VBN en-wikipedia-org-43 27 4 from from IN en-wikipedia-org-43 27 5 the the DT en-wikipedia-org-43 27 6 target target NN en-wikipedia-org-43 27 7 cells cell NNS en-wikipedia-org-43 27 8 , , , en-wikipedia-org-43 27 9 binds bind NNS en-wikipedia-org-43 27 10 to to IN en-wikipedia-org-43 27 11 and and CC en-wikipedia-org-43 27 12 activates activate VBZ en-wikipedia-org-43 27 13 its -PRON- PRP$ en-wikipedia-org-43 27 14 high high JJ en-wikipedia-org-43 27 15 affinity affinity NN en-wikipedia-org-43 27 16 receptor receptor NN en-wikipedia-org-43 27 17 TrkA TrkA NNP en-wikipedia-org-43 27 18 on on IN en-wikipedia-org-43 27 19 the the DT en-wikipedia-org-43 27 20 neuron neuron NN en-wikipedia-org-43 27 21 , , , en-wikipedia-org-43 27 22 and and CC en-wikipedia-org-43 27 23 is be VBZ en-wikipedia-org-43 27 24 internalized internalize VBN en-wikipedia-org-43 27 25 into into IN en-wikipedia-org-43 27 26 the the DT en-wikipedia-org-43 27 27 responsive responsive JJ en-wikipedia-org-43 27 28 neuron neuron NN en-wikipedia-org-43 27 29 . . . en-wikipedia-org-43 28 1 The the DT en-wikipedia-org-43 28 2 NGF NGF NNP en-wikipedia-org-43 28 3 / / SYM en-wikipedia-org-43 28 4 TrkA TrkA NNP en-wikipedia-org-43 28 5 complex complex NN en-wikipedia-org-43 28 6 is be VBZ en-wikipedia-org-43 28 7 subsequently subsequently RB en-wikipedia-org-43 28 8 trafficked traffic VBN en-wikipedia-org-43 28 9 back back RB en-wikipedia-org-43 28 10 to to IN en-wikipedia-org-43 28 11 the the DT en-wikipedia-org-43 28 12 neuron neuron NN en-wikipedia-org-43 28 13 's 's POS en-wikipedia-org-43 28 14 cell cell NN en-wikipedia-org-43 28 15 body body NN en-wikipedia-org-43 28 16 . . . en-wikipedia-org-43 29 1 This this DT en-wikipedia-org-43 29 2 movement movement NN en-wikipedia-org-43 29 3 of of IN en-wikipedia-org-43 29 4 NGF NGF NNP en-wikipedia-org-43 29 5 from from IN en-wikipedia-org-43 29 6 axon axon NNP en-wikipedia-org-43 29 7 tip tip NN en-wikipedia-org-43 29 8 to to IN en-wikipedia-org-43 29 9 soma soma NNP en-wikipedia-org-43 29 10 is be VBZ en-wikipedia-org-43 29 11 thought think VBN en-wikipedia-org-43 29 12 to to TO en-wikipedia-org-43 29 13 be be VB en-wikipedia-org-43 29 14 involved involve VBN en-wikipedia-org-43 29 15 in in IN en-wikipedia-org-43 29 16 the the DT en-wikipedia-org-43 29 17 long long JJ en-wikipedia-org-43 29 18 - - HYPH en-wikipedia-org-43 29 19 distance distance NN en-wikipedia-org-43 29 20 signaling signaling NN en-wikipedia-org-43 29 21 of of IN en-wikipedia-org-43 29 22 neurons neuron NNS en-wikipedia-org-43 29 23 . . . en-wikipedia-org-43 30 1 [ [ -LRB- en-wikipedia-org-43 30 2 15 15 CD en-wikipedia-org-43 30 3 ] ] -RRB- en-wikipedia-org-43 30 4 Brain brain NN en-wikipedia-org-43 30 5 - - HYPH en-wikipedia-org-43 30 6 derived derive VBN en-wikipedia-org-43 30 7 neurotrophic neurotrophic JJ en-wikipedia-org-43 30 8 factor[edit factor[edit . en-wikipedia-org-43 30 9 ] ] -RRB- en-wikipedia-org-43 30 10 Main main JJ en-wikipedia-org-43 30 11 article article NN en-wikipedia-org-43 30 12 : : : en-wikipedia-org-43 30 13 Brain brain NN en-wikipedia-org-43 30 14 - - HYPH en-wikipedia-org-43 30 15 derived derive VBN en-wikipedia-org-43 30 16 neurotrophic neurotrophic JJ en-wikipedia-org-43 30 17 factor factor NN en-wikipedia-org-43 30 18 Brain Brain NNP en-wikipedia-org-43 30 19 - - HYPH en-wikipedia-org-43 30 20 derived derive VBN en-wikipedia-org-43 30 21 neurotrophic neurotrophic JJ en-wikipedia-org-43 30 22 factor factor NN en-wikipedia-org-43 30 23 ( ( -LRB- en-wikipedia-org-43 30 24 BDNF BDNF NNP en-wikipedia-org-43 30 25 ) ) -RRB- en-wikipedia-org-43 30 26 is be VBZ en-wikipedia-org-43 30 27 a a DT en-wikipedia-org-43 30 28 neurotrophic neurotrophic JJ en-wikipedia-org-43 30 29 factor factor NN en-wikipedia-org-43 30 30 found find VBN en-wikipedia-org-43 30 31 originally originally RB en-wikipedia-org-43 30 32 in in IN en-wikipedia-org-43 30 33 the the DT en-wikipedia-org-43 30 34 brain brain NN en-wikipedia-org-43 30 35 , , , en-wikipedia-org-43 30 36 but but CC en-wikipedia-org-43 30 37 also also RB en-wikipedia-org-43 30 38 found find VBN en-wikipedia-org-43 30 39 in in IN en-wikipedia-org-43 30 40 the the DT en-wikipedia-org-43 30 41 periphery periphery NN en-wikipedia-org-43 30 42 . . . en-wikipedia-org-43 31 1 To to TO en-wikipedia-org-43 31 2 be be VB en-wikipedia-org-43 31 3 specific specific JJ en-wikipedia-org-43 31 4 , , , en-wikipedia-org-43 31 5 it -PRON- PRP en-wikipedia-org-43 31 6 is be VBZ en-wikipedia-org-43 31 7 a a DT en-wikipedia-org-43 31 8 protein protein NN en-wikipedia-org-43 31 9 that that WDT en-wikipedia-org-43 31 10 has have VBZ en-wikipedia-org-43 31 11 activity activity NN en-wikipedia-org-43 31 12 on on IN en-wikipedia-org-43 31 13 certain certain JJ en-wikipedia-org-43 31 14 neurons neuron NNS en-wikipedia-org-43 31 15 of of IN en-wikipedia-org-43 31 16 the the DT en-wikipedia-org-43 31 17 central central JJ en-wikipedia-org-43 31 18 nervous nervous JJ en-wikipedia-org-43 31 19 system system NN en-wikipedia-org-43 31 20 and and CC en-wikipedia-org-43 31 21 the the DT en-wikipedia-org-43 31 22 peripheral peripheral JJ en-wikipedia-org-43 31 23 nervous nervous JJ en-wikipedia-org-43 31 24 system system NN en-wikipedia-org-43 31 25 ; ; : en-wikipedia-org-43 31 26 it -PRON- PRP en-wikipedia-org-43 31 27 helps help VBZ en-wikipedia-org-43 31 28 to to TO en-wikipedia-org-43 31 29 support support VB en-wikipedia-org-43 31 30 the the DT en-wikipedia-org-43 31 31 survival survival NN en-wikipedia-org-43 31 32 of of IN en-wikipedia-org-43 31 33 existing exist VBG en-wikipedia-org-43 31 34 neurons neuron NNS en-wikipedia-org-43 31 35 , , , en-wikipedia-org-43 31 36 and and CC en-wikipedia-org-43 31 37 encourage encourage VB en-wikipedia-org-43 31 38 the the DT en-wikipedia-org-43 31 39 growth growth NN en-wikipedia-org-43 31 40 and and CC en-wikipedia-org-43 31 41 differentiation differentiation NN en-wikipedia-org-43 31 42 of of IN en-wikipedia-org-43 31 43 new new JJ en-wikipedia-org-43 31 44 neurons neuron NNS en-wikipedia-org-43 31 45 and and CC en-wikipedia-org-43 31 46 synapses synapsis NNS en-wikipedia-org-43 31 47 through through IN en-wikipedia-org-43 31 48 axonal axonal JJ en-wikipedia-org-43 31 49 and and CC en-wikipedia-org-43 31 50 dendritic dendritic JJ en-wikipedia-org-43 31 51 sprouting sprouting NN en-wikipedia-org-43 31 52 . . . en-wikipedia-org-43 32 1 In in IN en-wikipedia-org-43 32 2 the the DT en-wikipedia-org-43 32 3 brain brain NN en-wikipedia-org-43 32 4 , , , en-wikipedia-org-43 32 5 it -PRON- PRP en-wikipedia-org-43 32 6 is be VBZ en-wikipedia-org-43 32 7 active active JJ en-wikipedia-org-43 32 8 in in IN en-wikipedia-org-43 32 9 the the DT en-wikipedia-org-43 32 10 hippocampus hippocampus NNP en-wikipedia-org-43 32 11 , , , en-wikipedia-org-43 32 12 cortex cortex NNP en-wikipedia-org-43 32 13 , , , en-wikipedia-org-43 32 14 cerebellum cerebellum NN en-wikipedia-org-43 32 15 , , , en-wikipedia-org-43 32 16 and and CC en-wikipedia-org-43 32 17 basal basal NNP en-wikipedia-org-43 32 18 forebrain forebrain NNP en-wikipedia-org-43 32 19 — — : en-wikipedia-org-43 32 20 areas area NNS en-wikipedia-org-43 32 21 vital vital JJ en-wikipedia-org-43 32 22 to to IN en-wikipedia-org-43 32 23 learning learning NN en-wikipedia-org-43 32 24 , , , en-wikipedia-org-43 32 25 memory memory NN en-wikipedia-org-43 32 26 , , , en-wikipedia-org-43 32 27 and and CC en-wikipedia-org-43 32 28 higher high JJR en-wikipedia-org-43 32 29 thinking thinking NN en-wikipedia-org-43 32 30 . . . en-wikipedia-org-43 33 1 BDNF BDNF NNP en-wikipedia-org-43 33 2 was be VBD en-wikipedia-org-43 33 3 the the DT en-wikipedia-org-43 33 4 second second JJ en-wikipedia-org-43 33 5 neurotrophic neurotrophic JJ en-wikipedia-org-43 33 6 factor factor NN en-wikipedia-org-43 33 7 to to TO en-wikipedia-org-43 33 8 be be VB en-wikipedia-org-43 33 9 characterized characterize VBN en-wikipedia-org-43 33 10 , , , en-wikipedia-org-43 33 11 after after IN en-wikipedia-org-43 33 12 NGF NGF NNP en-wikipedia-org-43 33 13 and and CC en-wikipedia-org-43 33 14 before before IN en-wikipedia-org-43 33 15 neurotrophin-3 neurotrophin-3 NNP en-wikipedia-org-43 33 16 . . . en-wikipedia-org-43 34 1 BDNF BDNF NNP en-wikipedia-org-43 34 2 is be VBZ en-wikipedia-org-43 34 3 one one CD en-wikipedia-org-43 34 4 of of IN en-wikipedia-org-43 34 5 the the DT en-wikipedia-org-43 34 6 most most RBS en-wikipedia-org-43 34 7 active active JJ en-wikipedia-org-43 34 8 substances substance NNS en-wikipedia-org-43 34 9 to to TO en-wikipedia-org-43 34 10 stimulate stimulate VB en-wikipedia-org-43 34 11 neurogenesis neurogenesis NN en-wikipedia-org-43 34 12 . . . en-wikipedia-org-43 35 1 Mice mouse NNS en-wikipedia-org-43 35 2 born bear VBN en-wikipedia-org-43 35 3 without without IN en-wikipedia-org-43 35 4 the the DT en-wikipedia-org-43 35 5 ability ability NN en-wikipedia-org-43 35 6 to to TO en-wikipedia-org-43 35 7 make make VB en-wikipedia-org-43 35 8 BDNF BDNF NNP en-wikipedia-org-43 35 9 suffer suffer VB en-wikipedia-org-43 35 10 developmental developmental JJ en-wikipedia-org-43 35 11 defects defect NNS en-wikipedia-org-43 35 12 in in IN en-wikipedia-org-43 35 13 the the DT en-wikipedia-org-43 35 14 brain brain NN en-wikipedia-org-43 35 15 and and CC en-wikipedia-org-43 35 16 sensory sensory JJ en-wikipedia-org-43 35 17 nervous nervous JJ en-wikipedia-org-43 35 18 system system NN en-wikipedia-org-43 35 19 , , , en-wikipedia-org-43 35 20 and and CC en-wikipedia-org-43 35 21 usually usually RB en-wikipedia-org-43 35 22 die die VBP en-wikipedia-org-43 35 23 soon soon RB en-wikipedia-org-43 35 24 after after IN en-wikipedia-org-43 35 25 birth birth NN en-wikipedia-org-43 35 26 , , , en-wikipedia-org-43 35 27 suggesting suggest VBG en-wikipedia-org-43 35 28 that that IN en-wikipedia-org-43 35 29 BDNF BDNF NNP en-wikipedia-org-43 35 30 plays play VBZ en-wikipedia-org-43 35 31 an an DT en-wikipedia-org-43 35 32 important important JJ en-wikipedia-org-43 35 33 role role NN en-wikipedia-org-43 35 34 in in IN en-wikipedia-org-43 35 35 normal normal JJ en-wikipedia-org-43 35 36 neural neural JJ en-wikipedia-org-43 35 37 development development NN en-wikipedia-org-43 35 38 . . . en-wikipedia-org-43 36 1 Despite despite IN en-wikipedia-org-43 36 2 its -PRON- PRP$ en-wikipedia-org-43 36 3 name name NN en-wikipedia-org-43 36 4 , , , en-wikipedia-org-43 36 5 BDNF BDNF NNP en-wikipedia-org-43 36 6 is be VBZ en-wikipedia-org-43 36 7 actually actually RB en-wikipedia-org-43 36 8 found find VBN en-wikipedia-org-43 36 9 in in IN en-wikipedia-org-43 36 10 a a DT en-wikipedia-org-43 36 11 range range NN en-wikipedia-org-43 36 12 of of IN en-wikipedia-org-43 36 13 tissue tissue NN en-wikipedia-org-43 36 14 and and CC en-wikipedia-org-43 36 15 cell cell NN en-wikipedia-org-43 36 16 types type NNS en-wikipedia-org-43 36 17 , , , en-wikipedia-org-43 36 18 not not RB en-wikipedia-org-43 36 19 just just RB en-wikipedia-org-43 36 20 the the DT en-wikipedia-org-43 36 21 brain brain NN en-wikipedia-org-43 36 22 . . . en-wikipedia-org-43 37 1 Expression expression NN en-wikipedia-org-43 37 2 can can MD en-wikipedia-org-43 37 3 be be VB en-wikipedia-org-43 37 4 seen see VBN en-wikipedia-org-43 37 5 in in IN en-wikipedia-org-43 37 6 the the DT en-wikipedia-org-43 37 7 retina retina NNP en-wikipedia-org-43 37 8 , , , en-wikipedia-org-43 37 9 the the DT en-wikipedia-org-43 37 10 CNS CNS NNP en-wikipedia-org-43 37 11 , , , en-wikipedia-org-43 37 12 motor motor NN en-wikipedia-org-43 37 13 neurons neuron NNS en-wikipedia-org-43 37 14 , , , en-wikipedia-org-43 37 15 the the DT en-wikipedia-org-43 37 16 kidneys kidney NNS en-wikipedia-org-43 37 17 , , , en-wikipedia-org-43 37 18 and and CC en-wikipedia-org-43 37 19 the the DT en-wikipedia-org-43 37 20 prostate prostate NN en-wikipedia-org-43 37 21 . . . en-wikipedia-org-43 38 1 Exercise exercise NN en-wikipedia-org-43 38 2 has have VBZ en-wikipedia-org-43 38 3 been be VBN en-wikipedia-org-43 38 4 shown show VBN en-wikipedia-org-43 38 5 to to TO en-wikipedia-org-43 38 6 increase increase VB en-wikipedia-org-43 38 7 the the DT en-wikipedia-org-43 38 8 amount amount NN en-wikipedia-org-43 38 9 of of IN en-wikipedia-org-43 38 10 BDNF BDNF NNP en-wikipedia-org-43 38 11 and and CC en-wikipedia-org-43 38 12 therefore therefore RB en-wikipedia-org-43 38 13 serve serve VBP en-wikipedia-org-43 38 14 as as IN en-wikipedia-org-43 38 15 a a DT en-wikipedia-org-43 38 16 vehicle vehicle NN en-wikipedia-org-43 38 17 for for IN en-wikipedia-org-43 38 18 neuroplasticity neuroplasticity NN en-wikipedia-org-43 38 19 . . . en-wikipedia-org-43 39 1 [ [ -LRB- en-wikipedia-org-43 39 2 16 16 CD en-wikipedia-org-43 39 3 ] ] -RRB- en-wikipedia-org-43 39 4 Neurotrophin-3[edit neurotrophin-3[edit NN en-wikipedia-org-43 39 5 ] ] -RRB- en-wikipedia-org-43 39 6 Main main JJ en-wikipedia-org-43 39 7 article article NN en-wikipedia-org-43 39 8 : : : en-wikipedia-org-43 39 9 Neurotrophin-3 Neurotrophin-3 NNP en-wikipedia-org-43 39 10 Neurotrophin-3 Neurotrophin-3 NNP en-wikipedia-org-43 39 11 , , , en-wikipedia-org-43 39 12 or or CC en-wikipedia-org-43 39 13 NT-3 NT-3 NNP en-wikipedia-org-43 39 14 , , , en-wikipedia-org-43 39 15 is be VBZ en-wikipedia-org-43 39 16 a a DT en-wikipedia-org-43 39 17 neurotrophic neurotrophic JJ en-wikipedia-org-43 39 18 factor factor NN en-wikipedia-org-43 39 19 , , , en-wikipedia-org-43 39 20 in in IN en-wikipedia-org-43 39 21 the the DT en-wikipedia-org-43 39 22 NGF NGF NNP en-wikipedia-org-43 39 23 - - HYPH en-wikipedia-org-43 39 24 family family NN en-wikipedia-org-43 39 25 of of IN en-wikipedia-org-43 39 26 neurotrophins neurotrophin NNS en-wikipedia-org-43 39 27 . . . en-wikipedia-org-43 40 1 It -PRON- PRP en-wikipedia-org-43 40 2 is be VBZ en-wikipedia-org-43 40 3 a a DT en-wikipedia-org-43 40 4 protein protein NN en-wikipedia-org-43 40 5 growth growth NN en-wikipedia-org-43 40 6 factor factor NN en-wikipedia-org-43 40 7 that that WDT en-wikipedia-org-43 40 8 has have VBZ en-wikipedia-org-43 40 9 activity activity NN en-wikipedia-org-43 40 10 on on IN en-wikipedia-org-43 40 11 certain certain JJ en-wikipedia-org-43 40 12 neurons neuron NNS en-wikipedia-org-43 40 13 of of IN en-wikipedia-org-43 40 14 the the DT en-wikipedia-org-43 40 15 peripheral peripheral JJ en-wikipedia-org-43 40 16 and and CC en-wikipedia-org-43 40 17 central central JJ en-wikipedia-org-43 40 18 nervous nervous JJ en-wikipedia-org-43 40 19 system system NN en-wikipedia-org-43 40 20 ; ; : en-wikipedia-org-43 40 21 it -PRON- PRP en-wikipedia-org-43 40 22 helps help VBZ en-wikipedia-org-43 40 23 to to TO en-wikipedia-org-43 40 24 support support VB en-wikipedia-org-43 40 25 the the DT en-wikipedia-org-43 40 26 survival survival NN en-wikipedia-org-43 40 27 and and CC en-wikipedia-org-43 40 28 differentiation differentiation NN en-wikipedia-org-43 40 29 of of IN en-wikipedia-org-43 40 30 existing existing JJ en-wikipedia-org-43 40 31 neurons neuron NNS en-wikipedia-org-43 40 32 , , , en-wikipedia-org-43 40 33 and and CC en-wikipedia-org-43 40 34 encourages encourage VBZ en-wikipedia-org-43 40 35 the the DT en-wikipedia-org-43 40 36 growth growth NN en-wikipedia-org-43 40 37 and and CC en-wikipedia-org-43 40 38 differentiation differentiation NN en-wikipedia-org-43 40 39 of of IN en-wikipedia-org-43 40 40 new new JJ en-wikipedia-org-43 40 41 neurons neuron NNS en-wikipedia-org-43 40 42 and and CC en-wikipedia-org-43 40 43 synapses synapsis NNS en-wikipedia-org-43 40 44 . . . en-wikipedia-org-43 41 1 NT-3 nt-3 JJ en-wikipedia-org-43 41 2 is be VBZ en-wikipedia-org-43 41 3 the the DT en-wikipedia-org-43 41 4 third third JJ en-wikipedia-org-43 41 5 neurotrophic neurotrophic JJ en-wikipedia-org-43 41 6 factor factor NN en-wikipedia-org-43 41 7 to to TO en-wikipedia-org-43 41 8 be be VB en-wikipedia-org-43 41 9 characterized characterize VBN en-wikipedia-org-43 41 10 , , , en-wikipedia-org-43 41 11 after after IN en-wikipedia-org-43 41 12 NGF NGF NNP en-wikipedia-org-43 41 13 and and CC en-wikipedia-org-43 41 14 BDNF BDNF NNP en-wikipedia-org-43 41 15 . . . en-wikipedia-org-43 42 1 NT-3 nt-3 JJ en-wikipedia-org-43 42 2 is be VBZ en-wikipedia-org-43 42 3 unique unique JJ en-wikipedia-org-43 42 4 among among IN en-wikipedia-org-43 42 5 the the DT en-wikipedia-org-43 42 6 neurotrophins neurotrophin NNS en-wikipedia-org-43 42 7 in in IN en-wikipedia-org-43 42 8 the the DT en-wikipedia-org-43 42 9 number number NN en-wikipedia-org-43 42 10 of of IN en-wikipedia-org-43 42 11 neurons neuron NNS en-wikipedia-org-43 42 12 it -PRON- PRP en-wikipedia-org-43 42 13 has have VBZ en-wikipedia-org-43 42 14 potential potential JJ en-wikipedia-org-43 42 15 to to TO en-wikipedia-org-43 42 16 stimulate stimulate VB en-wikipedia-org-43 42 17 , , , en-wikipedia-org-43 42 18 given give VBN en-wikipedia-org-43 42 19 its -PRON- PRP$ en-wikipedia-org-43 42 20 ability ability NN en-wikipedia-org-43 42 21 to to TO en-wikipedia-org-43 42 22 activate activate VB en-wikipedia-org-43 42 23 two two CD en-wikipedia-org-43 42 24 of of IN en-wikipedia-org-43 42 25 the the DT en-wikipedia-org-43 42 26 receptor receptor NN en-wikipedia-org-43 42 27 tyrosine tyrosine NN en-wikipedia-org-43 42 28 kinase kinase NNP en-wikipedia-org-43 42 29 neurotrophin neurotrophin JJ en-wikipedia-org-43 42 30 receptors receptor NNS en-wikipedia-org-43 42 31 ( ( -LRB- en-wikipedia-org-43 42 32 TrkC TrkC NNP en-wikipedia-org-43 42 33 and and CC en-wikipedia-org-43 42 34 TrkB TrkB NNP en-wikipedia-org-43 42 35 ) ) -RRB- en-wikipedia-org-43 42 36 . . . en-wikipedia-org-43 43 1 Mice mouse NNS en-wikipedia-org-43 43 2 born bear VBN en-wikipedia-org-43 43 3 without without IN en-wikipedia-org-43 43 4 the the DT en-wikipedia-org-43 43 5 ability ability NN en-wikipedia-org-43 43 6 to to TO en-wikipedia-org-43 43 7 make make VB en-wikipedia-org-43 43 8 NT-3 nt-3 JJ en-wikipedia-org-43 43 9 have have VB en-wikipedia-org-43 43 10 loss loss NN en-wikipedia-org-43 43 11 of of IN en-wikipedia-org-43 43 12 proprioceptive proprioceptive JJ en-wikipedia-org-43 43 13 and and CC en-wikipedia-org-43 43 14 subsets subset NNS en-wikipedia-org-43 43 15 of of IN en-wikipedia-org-43 43 16 mechanoreceptive mechanoreceptive JJ en-wikipedia-org-43 43 17 sensory sensory JJ en-wikipedia-org-43 43 18 neurons neuron NNS en-wikipedia-org-43 43 19 . . . en-wikipedia-org-43 44 1 Neurotrophin-4[edit neurotrophin-4[edit JJ en-wikipedia-org-43 44 2 ] ] -RRB- en-wikipedia-org-43 44 3 Main main JJ en-wikipedia-org-43 44 4 article article NN en-wikipedia-org-43 44 5 : : : en-wikipedia-org-43 44 6 Neurotrophin-4 Neurotrophin-4 NNP en-wikipedia-org-43 44 7 Neurotrophin-4 Neurotrophin-4 NNP en-wikipedia-org-43 44 8 ( ( -LRB- en-wikipedia-org-43 44 9 NT-4 NT-4 NNP en-wikipedia-org-43 44 10 ) ) -RRB- en-wikipedia-org-43 44 11 is be VBZ en-wikipedia-org-43 44 12 a a DT en-wikipedia-org-43 44 13 neurotrophic neurotrophic JJ en-wikipedia-org-43 44 14 factor factor NN en-wikipedia-org-43 44 15 that that WDT en-wikipedia-org-43 44 16 signals signal VBZ en-wikipedia-org-43 44 17 predominantly predominantly RB en-wikipedia-org-43 44 18 through through IN en-wikipedia-org-43 44 19 the the DT en-wikipedia-org-43 44 20 TrkB TrkB NNP en-wikipedia-org-43 44 21 receptor receptor NN en-wikipedia-org-43 44 22 tyrosine tyrosine NN en-wikipedia-org-43 44 23 kinase kinase NN en-wikipedia-org-43 44 24 . . . en-wikipedia-org-43 45 1 It -PRON- PRP en-wikipedia-org-43 45 2 is be VBZ en-wikipedia-org-43 45 3 also also RB en-wikipedia-org-43 45 4 known know VBN en-wikipedia-org-43 45 5 as as IN en-wikipedia-org-43 45 6 NT4 NT4 NNP en-wikipedia-org-43 45 7 , , , en-wikipedia-org-43 45 8 NT5 NT5 NNP en-wikipedia-org-43 45 9 , , , en-wikipedia-org-43 45 10 NTF4 NTF4 NNP en-wikipedia-org-43 45 11 , , , en-wikipedia-org-43 45 12 and and CC en-wikipedia-org-43 45 13 NT-4/5 NT-4/5 NNP en-wikipedia-org-43 45 14 . . . en-wikipedia-org-43 46 1 [ [ -LRB- en-wikipedia-org-43 46 2 17 17 CD en-wikipedia-org-43 46 3 ] ] -RRB- en-wikipedia-org-43 46 4 DHEA dhea NN en-wikipedia-org-43 46 5 and and CC en-wikipedia-org-43 46 6 DHEA dhea NN en-wikipedia-org-43 46 7 sulfate[edit sulfate[edit LS en-wikipedia-org-43 46 8 ] ] -RRB- en-wikipedia-org-43 46 9 Main main JJ en-wikipedia-org-43 46 10 articles article NNS en-wikipedia-org-43 46 11 : : : en-wikipedia-org-43 46 12 Dehydroepiandrosterone Dehydroepiandrosterone NNP en-wikipedia-org-43 46 13 and and CC en-wikipedia-org-43 46 14 Dehydroepiandrosterone Dehydroepiandrosterone NNP en-wikipedia-org-43 46 15 sulfate sulfate VBP en-wikipedia-org-43 46 16 The the DT en-wikipedia-org-43 46 17 endogenous endogenous JJ en-wikipedia-org-43 46 18 steroids steroid NNS en-wikipedia-org-43 46 19 dehydroepiandrosterone dehydroepiandrosterone VBN en-wikipedia-org-43 46 20 ( ( -LRB- en-wikipedia-org-43 46 21 DHEA DHEA NNP en-wikipedia-org-43 46 22 ) ) -RRB- en-wikipedia-org-43 46 23 and and CC en-wikipedia-org-43 46 24 its -PRON- PRP$ en-wikipedia-org-43 46 25 sulfate sulfate NN en-wikipedia-org-43 46 26 ester ester NN en-wikipedia-org-43 46 27 , , , en-wikipedia-org-43 46 28 DHEA dhea NN en-wikipedia-org-43 46 29 sulfate sulfate NN en-wikipedia-org-43 46 30 ( ( -LRB- en-wikipedia-org-43 46 31 DHEA DHEA NNP en-wikipedia-org-43 46 32 - - HYPH en-wikipedia-org-43 46 33 S S NNP en-wikipedia-org-43 46 34 ) ) -RRB- en-wikipedia-org-43 46 35 , , , en-wikipedia-org-43 46 36 have have VBP en-wikipedia-org-43 46 37 been be VBN en-wikipedia-org-43 46 38 identified identify VBN en-wikipedia-org-43 46 39 as as IN en-wikipedia-org-43 46 40 small small JJ en-wikipedia-org-43 46 41 - - HYPH en-wikipedia-org-43 46 42 molecule molecule NN en-wikipedia-org-43 46 43 agonists agonist NNS en-wikipedia-org-43 46 44 of of IN en-wikipedia-org-43 46 45 the the DT en-wikipedia-org-43 46 46 TrkA TrkA NNP en-wikipedia-org-43 46 47 and and CC en-wikipedia-org-43 46 48 p75NTR p75ntr NN en-wikipedia-org-43 46 49 with with IN en-wikipedia-org-43 46 50 high high JJ en-wikipedia-org-43 46 51 affinity affinity NN en-wikipedia-org-43 46 52 ( ( -LRB- en-wikipedia-org-43 46 53 around around RB en-wikipedia-org-43 46 54 5 5 CD en-wikipedia-org-43 46 55   _SP en-wikipedia-org-43 46 56 nM nM NNP en-wikipedia-org-43 46 57 ) ) -RRB- en-wikipedia-org-43 46 58 , , , en-wikipedia-org-43 46 59 and and CC en-wikipedia-org-43 46 60 hence hence RB en-wikipedia-org-43 46 61 as as IN en-wikipedia-org-43 46 62 so so RB en-wikipedia-org-43 46 63 - - HYPH en-wikipedia-org-43 46 64 called call VBN en-wikipedia-org-43 46 65 " " `` en-wikipedia-org-43 46 66 microneurotrophins microneurotrophin NNS en-wikipedia-org-43 46 67 " " '' en-wikipedia-org-43 46 68 . . . en-wikipedia-org-43 47 1 [ [ -LRB- en-wikipedia-org-43 47 2 18][19][20][21 18][19][20][21 CD en-wikipedia-org-43 47 3 ] ] -RRB- en-wikipedia-org-43 47 4 DHEA dhea NN en-wikipedia-org-43 47 5 has have VBZ en-wikipedia-org-43 47 6 also also RB en-wikipedia-org-43 47 7 been be VBN en-wikipedia-org-43 47 8 found find VBN en-wikipedia-org-43 47 9 to to TO en-wikipedia-org-43 47 10 bind bind VB en-wikipedia-org-43 47 11 to to IN en-wikipedia-org-43 47 12 the the DT en-wikipedia-org-43 47 13 TrkB TrkB NNP en-wikipedia-org-43 47 14 and and CC en-wikipedia-org-43 47 15 TrkC TrkC NNP en-wikipedia-org-43 47 16 , , , en-wikipedia-org-43 47 17 though though IN en-wikipedia-org-43 47 18 while while IN en-wikipedia-org-43 47 19 it -PRON- PRP en-wikipedia-org-43 47 20 activated activate VBD en-wikipedia-org-43 47 21 the the DT en-wikipedia-org-43 47 22 TrkC TrkC NNP en-wikipedia-org-43 47 23 , , , en-wikipedia-org-43 47 24 it -PRON- PRP en-wikipedia-org-43 47 25 was be VBD en-wikipedia-org-43 47 26 unable unable JJ en-wikipedia-org-43 47 27 to to TO en-wikipedia-org-43 47 28 activate activate VB en-wikipedia-org-43 47 29 the the DT en-wikipedia-org-43 47 30 TrkB. trkb. NN en-wikipedia-org-43 48 1 [ [ -LRB- en-wikipedia-org-43 48 2 18 18 CD en-wikipedia-org-43 48 3 ] ] -RRB- en-wikipedia-org-43 48 4 It -PRON- PRP en-wikipedia-org-43 48 5 has have VBZ en-wikipedia-org-43 48 6 been be VBN en-wikipedia-org-43 48 7 proposed propose VBN en-wikipedia-org-43 48 8 that that IN en-wikipedia-org-43 48 9 DHEA DHEA NNP en-wikipedia-org-43 48 10 may may MD en-wikipedia-org-43 48 11 have have VB en-wikipedia-org-43 48 12 been be VBN en-wikipedia-org-43 48 13 the the DT en-wikipedia-org-43 48 14 ancestral ancestral JJ en-wikipedia-org-43 48 15 ligand ligand NN en-wikipedia-org-43 48 16 of of IN en-wikipedia-org-43 48 17 the the DT en-wikipedia-org-43 48 18 Trk Trk NNP en-wikipedia-org-43 48 19 receptors receptor NNS en-wikipedia-org-43 48 20 early early RB en-wikipedia-org-43 48 21 on on RB en-wikipedia-org-43 48 22 in in IN en-wikipedia-org-43 48 23 the the DT en-wikipedia-org-43 48 24 evolution evolution NN en-wikipedia-org-43 48 25 of of IN en-wikipedia-org-43 48 26 the the DT en-wikipedia-org-43 48 27 nervous nervous JJ en-wikipedia-org-43 48 28 system system NN en-wikipedia-org-43 48 29 , , , en-wikipedia-org-43 48 30 eventually eventually RB en-wikipedia-org-43 48 31 being be VBG en-wikipedia-org-43 48 32 superseded supersede VBN en-wikipedia-org-43 48 33 by by IN en-wikipedia-org-43 48 34 the the DT en-wikipedia-org-43 48 35 polypeptide polypeptide NN en-wikipedia-org-43 48 36 neurotrophins neurotrophin NNS en-wikipedia-org-43 48 37 . . . en-wikipedia-org-43 49 1 [ [ -LRB- en-wikipedia-org-43 49 2 18][20 18][20 LS en-wikipedia-org-43 49 3 ] ] -RRB- en-wikipedia-org-43 49 4 Role Role NNP en-wikipedia-org-43 49 5 in in IN en-wikipedia-org-43 49 6 programmed program VBN en-wikipedia-org-43 49 7 cell cell NN en-wikipedia-org-43 49 8 death[edit death[edit . en-wikipedia-org-43 49 9 ] ] -RRB- en-wikipedia-org-43 49 10 The the DT en-wikipedia-org-43 49 11 dimerization dimerization NN en-wikipedia-org-43 49 12 of of IN en-wikipedia-org-43 49 13 p75NTR p75ntr NN en-wikipedia-org-43 49 14 when when WRB en-wikipedia-org-43 49 15 bound bind VBN en-wikipedia-org-43 49 16 to to IN en-wikipedia-org-43 49 17 proneurotrophins proneurotrophin NNS en-wikipedia-org-43 49 18 and and CC en-wikipedia-org-43 49 19 sortilin sortilin NN en-wikipedia-org-43 49 20 leads lead VBZ en-wikipedia-org-43 49 21 to to IN en-wikipedia-org-43 49 22 apoptosis apoptosis NN en-wikipedia-org-43 49 23 via via IN en-wikipedia-org-43 49 24 the the DT en-wikipedia-org-43 49 25 JNK JNK NNP en-wikipedia-org-43 49 26 cascade cascade NN en-wikipedia-org-43 49 27 . . . en-wikipedia-org-43 50 1 During during IN en-wikipedia-org-43 50 2 neuron neuron NNP en-wikipedia-org-43 50 3 development development NN en-wikipedia-org-43 50 4 neurotrophins neurotrophin NNS en-wikipedia-org-43 50 5 play play VB en-wikipedia-org-43 50 6 a a DT en-wikipedia-org-43 50 7 key key JJ en-wikipedia-org-43 50 8 role role NN en-wikipedia-org-43 50 9 in in IN en-wikipedia-org-43 50 10 growth growth NN en-wikipedia-org-43 50 11 , , , en-wikipedia-org-43 50 12 differentiation differentiation NN en-wikipedia-org-43 50 13 , , , en-wikipedia-org-43 50 14 and and CC en-wikipedia-org-43 50 15 survival survival NN en-wikipedia-org-43 50 16 . . . en-wikipedia-org-43 51 1 [ [ -LRB- en-wikipedia-org-43 51 2 22 22 CD en-wikipedia-org-43 51 3 ] ] -RRB- en-wikipedia-org-43 51 4 They -PRON- PRP en-wikipedia-org-43 51 5 also also RB en-wikipedia-org-43 51 6 play play VBP en-wikipedia-org-43 51 7 and and CC en-wikipedia-org-43 51 8 important important JJ en-wikipedia-org-43 51 9 role role NN en-wikipedia-org-43 51 10 in in IN en-wikipedia-org-43 51 11 the the DT en-wikipedia-org-43 51 12 apoptotic apoptotic JJ en-wikipedia-org-43 51 13 programmed program VBN en-wikipedia-org-43 51 14 cell cell NN en-wikipedia-org-43 51 15 death death NN en-wikipedia-org-43 51 16 ( ( -LRB- en-wikipedia-org-43 51 17 PCD PCD NNP en-wikipedia-org-43 51 18 ) ) -RRB- en-wikipedia-org-43 51 19 of of IN en-wikipedia-org-43 51 20 neurons neuron NNS en-wikipedia-org-43 51 21 . . . en-wikipedia-org-43 52 1 [ [ -LRB- en-wikipedia-org-43 52 2 23 23 CD en-wikipedia-org-43 52 3 ] ] -RRB- en-wikipedia-org-43 52 4 Neurotrophic neurotrophic JJ en-wikipedia-org-43 52 5 survival survival NN en-wikipedia-org-43 52 6 signals signal NNS en-wikipedia-org-43 52 7 in in IN en-wikipedia-org-43 52 8 neurons neuron NNS en-wikipedia-org-43 52 9 are be VBP en-wikipedia-org-43 52 10 mediated mediate VBN en-wikipedia-org-43 52 11 by by IN en-wikipedia-org-43 52 12 the the DT en-wikipedia-org-43 52 13 high high JJ en-wikipedia-org-43 52 14 - - HYPH en-wikipedia-org-43 52 15 affinity affinity NN en-wikipedia-org-43 52 16 binding binding NN en-wikipedia-org-43 52 17 of of IN en-wikipedia-org-43 52 18 neurotrophins neurotrophin NNS en-wikipedia-org-43 52 19 to to IN en-wikipedia-org-43 52 20 their -PRON- PRP$ en-wikipedia-org-43 52 21 respective respective JJ en-wikipedia-org-43 52 22 Trk Trk NNP en-wikipedia-org-43 52 23 receptor receptor NN en-wikipedia-org-43 52 24 . . . en-wikipedia-org-43 53 1 [ [ -LRB- en-wikipedia-org-43 53 2 22 22 CD en-wikipedia-org-43 53 3 ] ] -RRB- en-wikipedia-org-43 53 4 In in IN en-wikipedia-org-43 53 5 turn turn NN en-wikipedia-org-43 53 6 , , , en-wikipedia-org-43 53 7 a a DT en-wikipedia-org-43 53 8 majority majority NN en-wikipedia-org-43 53 9 of of IN en-wikipedia-org-43 53 10 neuronal neuronal JJ en-wikipedia-org-43 53 11 apoptotic apoptotic JJ en-wikipedia-org-43 53 12 signals signal NNS en-wikipedia-org-43 53 13 are be VBP en-wikipedia-org-43 53 14 mediated mediate VBN en-wikipedia-org-43 53 15 by by IN en-wikipedia-org-43 53 16 neurotrophins neurotrophin NNS en-wikipedia-org-43 53 17 binding bind VBG en-wikipedia-org-43 53 18 to to IN en-wikipedia-org-43 53 19 the the DT en-wikipedia-org-43 53 20 p75NTR p75ntr NN en-wikipedia-org-43 53 21 . . . en-wikipedia-org-43 54 1 [ [ -LRB- en-wikipedia-org-43 54 2 23 23 CD en-wikipedia-org-43 54 3 ] ] -RRB- en-wikipedia-org-43 54 4 The the DT en-wikipedia-org-43 54 5 PCD pcd NN en-wikipedia-org-43 54 6 which which WDT en-wikipedia-org-43 54 7 occurs occur VBZ en-wikipedia-org-43 54 8 during during IN en-wikipedia-org-43 54 9 brain brain NN en-wikipedia-org-43 54 10 development development NN en-wikipedia-org-43 54 11 is be VBZ en-wikipedia-org-43 54 12 responsible responsible JJ en-wikipedia-org-43 54 13 for for IN en-wikipedia-org-43 54 14 the the DT en-wikipedia-org-43 54 15 loss loss NN en-wikipedia-org-43 54 16 of of IN en-wikipedia-org-43 54 17 a a DT en-wikipedia-org-43 54 18 majority majority NN en-wikipedia-org-43 54 19 of of IN en-wikipedia-org-43 54 20 neuroblasts neuroblast NNS en-wikipedia-org-43 54 21 and and CC en-wikipedia-org-43 54 22 differentiating differentiate VBG en-wikipedia-org-43 54 23 neurons neuron NNS en-wikipedia-org-43 54 24 . . . en-wikipedia-org-43 55 1 [ [ -LRB- en-wikipedia-org-43 55 2 22 22 CD en-wikipedia-org-43 55 3 ] ] -RRB- en-wikipedia-org-43 55 4 It -PRON- PRP en-wikipedia-org-43 55 5 is be VBZ en-wikipedia-org-43 55 6 necessary necessary JJ en-wikipedia-org-43 55 7 because because IN en-wikipedia-org-43 55 8 during during IN en-wikipedia-org-43 55 9 development development NN en-wikipedia-org-43 55 10 there there EX en-wikipedia-org-43 55 11 is be VBZ en-wikipedia-org-43 55 12 a a DT en-wikipedia-org-43 55 13 massive massive JJ en-wikipedia-org-43 55 14 over over IN en-wikipedia-org-43 55 15 production production NN en-wikipedia-org-43 55 16 of of IN en-wikipedia-org-43 55 17 neurons neuron NNS en-wikipedia-org-43 55 18 which which WDT en-wikipedia-org-43 55 19 must must MD en-wikipedia-org-43 55 20 be be VB en-wikipedia-org-43 55 21 killed kill VBN en-wikipedia-org-43 55 22 off off RP en-wikipedia-org-43 55 23 to to TO en-wikipedia-org-43 55 24 attain attain VB en-wikipedia-org-43 55 25 optimal optimal JJ en-wikipedia-org-43 55 26 function function NN en-wikipedia-org-43 55 27 . . . en-wikipedia-org-43 56 1 [ [ -LRB- en-wikipedia-org-43 56 2 22][23 22][23 CD en-wikipedia-org-43 56 3 ] ] -RRB- en-wikipedia-org-43 56 4 In in IN en-wikipedia-org-43 56 5 the the DT en-wikipedia-org-43 56 6 development development NN en-wikipedia-org-43 56 7 of of IN en-wikipedia-org-43 56 8 both both CC en-wikipedia-org-43 56 9 the the DT en-wikipedia-org-43 56 10 peripheral peripheral JJ en-wikipedia-org-43 56 11 nervous nervous JJ en-wikipedia-org-43 56 12 system system NN en-wikipedia-org-43 56 13 ( ( -LRB- en-wikipedia-org-43 56 14 PNS PNS NNP en-wikipedia-org-43 56 15 ) ) -RRB- en-wikipedia-org-43 56 16 and and CC en-wikipedia-org-43 56 17 the the DT en-wikipedia-org-43 56 18 central central JJ en-wikipedia-org-43 56 19 nervous nervous JJ en-wikipedia-org-43 56 20 system system NN en-wikipedia-org-43 56 21 ( ( -LRB- en-wikipedia-org-43 56 22 CNS cns NN en-wikipedia-org-43 56 23 ) ) -RRB- en-wikipedia-org-43 56 24 the the DT en-wikipedia-org-43 56 25 p75NTR p75ntr NN en-wikipedia-org-43 56 26 - - HYPH en-wikipedia-org-43 56 27 neurotrophin neurotrophin NN en-wikipedia-org-43 56 28 binding binding NN en-wikipedia-org-43 56 29 activates activate VBZ en-wikipedia-org-43 56 30 multiple multiple JJ en-wikipedia-org-43 56 31 intracellular intracellular JJ en-wikipedia-org-43 56 32 pathways pathway NNS en-wikipedia-org-43 56 33 which which WDT en-wikipedia-org-43 56 34 are be VBP en-wikipedia-org-43 56 35 important important JJ en-wikipedia-org-43 56 36 in in IN en-wikipedia-org-43 56 37 regulating regulate VBG en-wikipedia-org-43 56 38 apoptosis apoptosis NN en-wikipedia-org-43 56 39 . . . en-wikipedia-org-43 57 1 [ [ -LRB- en-wikipedia-org-43 57 2 22][24 22][24 CD en-wikipedia-org-43 57 3 ] ] -RRB- en-wikipedia-org-43 57 4 Proneurotrophins Proneurotrophins NNP en-wikipedia-org-43 57 5 ( ( -LRB- en-wikipedia-org-43 57 6 proNTs pronts NN en-wikipedia-org-43 57 7 ) ) -RRB- en-wikipedia-org-43 57 8 are be VBP en-wikipedia-org-43 57 9 neurotrophins neurotrophin NNS en-wikipedia-org-43 57 10 which which WDT en-wikipedia-org-43 57 11 are be VBP en-wikipedia-org-43 57 12 released release VBN en-wikipedia-org-43 57 13 as as IN en-wikipedia-org-43 57 14 biologically biologically RB en-wikipedia-org-43 57 15 active active JJ en-wikipedia-org-43 57 16 uncleaved uncleave VBD en-wikipedia-org-43 57 17 pro pro NN en-wikipedia-org-43 57 18 - - NNS en-wikipedia-org-43 57 19 peptides peptide NNS en-wikipedia-org-43 57 20 . . . en-wikipedia-org-43 58 1 [ [ -LRB- en-wikipedia-org-43 58 2 22 22 CD en-wikipedia-org-43 58 3 ] ] -RRB- en-wikipedia-org-43 58 4 Unlike unlike IN en-wikipedia-org-43 58 5 mature mature JJ en-wikipedia-org-43 58 6 neurotrophins neurotrophin NNS en-wikipedia-org-43 58 7 which which WDT en-wikipedia-org-43 58 8 bind bind VBP en-wikipedia-org-43 58 9 to to IN en-wikipedia-org-43 58 10 the the DT en-wikipedia-org-43 58 11 p75NTR p75ntr NN en-wikipedia-org-43 58 12 with with IN en-wikipedia-org-43 58 13 a a DT en-wikipedia-org-43 58 14 low low JJ en-wikipedia-org-43 58 15 affinity affinity NN en-wikipedia-org-43 58 16 , , , en-wikipedia-org-43 58 17 proNTs proNTs , en-wikipedia-org-43 58 18 preferentially preferentially RB en-wikipedia-org-43 58 19 bind bind VBP en-wikipedia-org-43 58 20 to to IN en-wikipedia-org-43 58 21 the the DT en-wikipedia-org-43 58 22 p75NTR p75ntr NN en-wikipedia-org-43 58 23 with with IN en-wikipedia-org-43 58 24 high high JJ en-wikipedia-org-43 58 25 affinity affinity NN en-wikipedia-org-43 58 26 . . . en-wikipedia-org-43 59 1 [ [ -LRB- en-wikipedia-org-43 59 2 25][26 25][26 LS en-wikipedia-org-43 59 3 ] ] -RRB- en-wikipedia-org-43 59 4 The the DT en-wikipedia-org-43 59 5 p75NTR p75ntr NN en-wikipedia-org-43 59 6 contains contain VBZ en-wikipedia-org-43 59 7 a a DT en-wikipedia-org-43 59 8 death death NN en-wikipedia-org-43 59 9 domain domain NN en-wikipedia-org-43 59 10 on on IN en-wikipedia-org-43 59 11 its -PRON- PRP$ en-wikipedia-org-43 59 12 cytoplasmic cytoplasmic JJ en-wikipedia-org-43 59 13 tail tail NN en-wikipedia-org-43 59 14 which which WDT en-wikipedia-org-43 59 15 when when WRB en-wikipedia-org-43 59 16 cleaved cleave VBD en-wikipedia-org-43 59 17 activates activate VBZ en-wikipedia-org-43 59 18 an an DT en-wikipedia-org-43 59 19 apoptotic apoptotic JJ en-wikipedia-org-43 59 20 pathway pathway NN en-wikipedia-org-43 59 21 . . . en-wikipedia-org-43 60 1 [ [ -LRB- en-wikipedia-org-43 60 2 22][23][27 22][23][27 CD en-wikipedia-org-43 60 3 ] ] -RRB- en-wikipedia-org-43 60 4 The the DT en-wikipedia-org-43 60 5 binding binding NN en-wikipedia-org-43 60 6 of of IN en-wikipedia-org-43 60 7 a a DT en-wikipedia-org-43 60 8 proNT pront NN en-wikipedia-org-43 60 9 ( ( -LRB- en-wikipedia-org-43 60 10 proNGF proNGF NNP en-wikipedia-org-43 60 11 or or CC en-wikipedia-org-43 60 12 proBDNF proBDNF NNP en-wikipedia-org-43 60 13 ) ) -RRB- en-wikipedia-org-43 60 14 to to TO en-wikipedia-org-43 60 15 p75NTR p75ntr VB en-wikipedia-org-43 60 16 and and CC en-wikipedia-org-43 60 17 its -PRON- PRP$ en-wikipedia-org-43 60 18 sortilin sortilin JJ en-wikipedia-org-43 60 19 co co NN en-wikipedia-org-43 60 20 - - NN en-wikipedia-org-43 60 21 receptor receptor NN en-wikipedia-org-43 60 22 ( ( -LRB- en-wikipedia-org-43 60 23 which which WDT en-wikipedia-org-43 60 24 binds bind VBZ en-wikipedia-org-43 60 25 the the DT en-wikipedia-org-43 60 26 pro pro JJ en-wikipedia-org-43 60 27 - - JJ en-wikipedia-org-43 60 28 domain domain NN en-wikipedia-org-43 60 29 of of IN en-wikipedia-org-43 60 30 proNTs pronts NN en-wikipedia-org-43 60 31 ) ) -RRB- en-wikipedia-org-43 60 32 causes cause VBZ en-wikipedia-org-43 60 33 a a DT en-wikipedia-org-43 60 34 p75NTR p75ntr NN en-wikipedia-org-43 60 35 - - HYPH en-wikipedia-org-43 60 36 dependent dependent JJ en-wikipedia-org-43 60 37 signal signal NN en-wikipedia-org-43 60 38 transduction transduction NN en-wikipedia-org-43 60 39 cascade cascade NN en-wikipedia-org-43 60 40 . . . en-wikipedia-org-43 61 1 [ [ -LRB- en-wikipedia-org-43 61 2 22][23][25][27 22][23][25][27 CD en-wikipedia-org-43 61 3 ] ] -RRB- en-wikipedia-org-43 61 4 The the DT en-wikipedia-org-43 61 5 cleaved cleave VBN en-wikipedia-org-43 61 6 death death NN en-wikipedia-org-43 61 7 domain domain NN en-wikipedia-org-43 61 8 of of IN en-wikipedia-org-43 61 9 p75NTR p75ntr NN en-wikipedia-org-43 61 10 activates activate VBZ en-wikipedia-org-43 61 11 c c NN en-wikipedia-org-43 61 12 - - : en-wikipedia-org-43 61 13 Jun Jun NNP en-wikipedia-org-43 61 14 N N NNP en-wikipedia-org-43 61 15 - - HYPH en-wikipedia-org-43 61 16 terminal terminal NN en-wikipedia-org-43 61 17 kinase kinase NN en-wikipedia-org-43 61 18 ( ( -LRB- en-wikipedia-org-43 61 19 JNK JNK NNP en-wikipedia-org-43 61 20 ) ) -RRB- en-wikipedia-org-43 61 21 . . . en-wikipedia-org-43 62 1 [ [ -LRB- en-wikipedia-org-43 62 2 23][28][29 23][28][29 CD en-wikipedia-org-43 62 3 ] ] -RRB- en-wikipedia-org-43 62 4 The the DT en-wikipedia-org-43 62 5 activated activated JJ en-wikipedia-org-43 62 6 JNK JNK NNP en-wikipedia-org-43 62 7 translocates translocate VBZ en-wikipedia-org-43 62 8 into into IN en-wikipedia-org-43 62 9 the the DT en-wikipedia-org-43 62 10 nucleus nucleus NN en-wikipedia-org-43 62 11 , , , en-wikipedia-org-43 62 12 where where WRB en-wikipedia-org-43 62 13 it -PRON- PRP en-wikipedia-org-43 62 14 phosphorylates phosphorylate VBZ en-wikipedia-org-43 62 15 and and CC en-wikipedia-org-43 62 16 transactivates transactivate VBZ en-wikipedia-org-43 62 17 c c NN en-wikipedia-org-43 62 18 - - : en-wikipedia-org-43 62 19 Jun Jun NNP en-wikipedia-org-43 62 20 . . . en-wikipedia-org-43 63 1 [ [ -LRB- en-wikipedia-org-43 63 2 23][28 23][28 CD en-wikipedia-org-43 63 3 ] ] -RRB- en-wikipedia-org-43 63 4 The the DT en-wikipedia-org-43 63 5 transactivation transactivation NN en-wikipedia-org-43 63 6 of of IN en-wikipedia-org-43 63 7 c c NNP en-wikipedia-org-43 63 8 - - : en-wikipedia-org-43 63 9 Jun Jun NNP en-wikipedia-org-43 63 10 results result NNS en-wikipedia-org-43 63 11 in in IN en-wikipedia-org-43 63 12 the the DT en-wikipedia-org-43 63 13 transcription transcription NN en-wikipedia-org-43 63 14 of of IN en-wikipedia-org-43 63 15 pro pro JJ en-wikipedia-org-43 63 16 - - JJ en-wikipedia-org-43 63 17 apoptotic apoptotic JJ en-wikipedia-org-43 63 18 factors factor NNS en-wikipedia-org-43 63 19 TFF TFF NNP en-wikipedia-org-43 63 20 - - HYPH en-wikipedia-org-43 63 21 a a NNP en-wikipedia-org-43 63 22 , , , en-wikipedia-org-43 63 23 Fas Fas NNP en-wikipedia-org-43 63 24 - - HYPH en-wikipedia-org-43 63 25 L L NNP en-wikipedia-org-43 63 26 and and CC en-wikipedia-org-43 63 27 Bak Bak NNP en-wikipedia-org-43 63 28 . . . en-wikipedia-org-43 64 1 [ [ -LRB- en-wikipedia-org-43 64 2 22][23][25][27][28][29][30 22][23][25][27][28][29][30 LS en-wikipedia-org-43 64 3 ] ] -RRB- en-wikipedia-org-43 64 4 The the DT en-wikipedia-org-43 64 5 importance importance NN en-wikipedia-org-43 64 6 of of IN en-wikipedia-org-43 64 7 sotilin sotilin NN en-wikipedia-org-43 64 8 in in IN en-wikipedia-org-43 64 9 p75NTR p75ntr NN en-wikipedia-org-43 64 10 - - HYPH en-wikipedia-org-43 64 11 mediated mediate VBN en-wikipedia-org-43 64 12 apoptosis apoptosis NN en-wikipedia-org-43 64 13 is be VBZ en-wikipedia-org-43 64 14 exhibited exhibit VBN en-wikipedia-org-43 64 15 by by IN en-wikipedia-org-43 64 16 the the DT en-wikipedia-org-43 64 17 fact fact NN en-wikipedia-org-43 64 18 that that IN en-wikipedia-org-43 64 19 the the DT en-wikipedia-org-43 64 20 inhibition inhibition NN en-wikipedia-org-43 64 21 of of IN en-wikipedia-org-43 64 22 sortilin sortilin JJ en-wikipedia-org-43 64 23 expression expression NN en-wikipedia-org-43 64 24 in in IN en-wikipedia-org-43 64 25 neurons neuron NNS en-wikipedia-org-43 64 26 expressing express VBG en-wikipedia-org-43 64 27 p75NTR p75ntr NN en-wikipedia-org-43 64 28 suppresses suppresse NNS en-wikipedia-org-43 64 29 proNGF prongf NN en-wikipedia-org-43 64 30 - - HYPH en-wikipedia-org-43 64 31 mediated mediate VBN en-wikipedia-org-43 64 32 apoptosis apoptosis NN en-wikipedia-org-43 64 33 , , , en-wikipedia-org-43 64 34 and and CC en-wikipedia-org-43 64 35 the the DT en-wikipedia-org-43 64 36 prevention prevention NN en-wikipedia-org-43 64 37 of of IN en-wikipedia-org-43 64 38 proBDNF proBDNF NNP en-wikipedia-org-43 64 39 binding bind VBG en-wikipedia-org-43 64 40 to to IN en-wikipedia-org-43 64 41 p75NTR p75ntr NN en-wikipedia-org-43 64 42 and and CC en-wikipedia-org-43 64 43 sortilin sortilin NN en-wikipedia-org-43 64 44 abolished abolish VBD en-wikipedia-org-43 64 45 apoptotic apoptotic JJ en-wikipedia-org-43 64 46 action action NN en-wikipedia-org-43 64 47 . . . en-wikipedia-org-43 65 1 [ [ -LRB- en-wikipedia-org-43 65 2 25 25 CD en-wikipedia-org-43 65 3 ] ] -RRB- en-wikipedia-org-43 65 4 Activation activation NN en-wikipedia-org-43 65 5 of of IN en-wikipedia-org-43 65 6 p75NTR p75ntr NN en-wikipedia-org-43 65 7 - - HYPH en-wikipedia-org-43 65 8 mediated mediate VBN en-wikipedia-org-43 65 9 apoptosis apoptosis NN en-wikipedia-org-43 65 10 is be VBZ en-wikipedia-org-43 65 11 much much RB en-wikipedia-org-43 65 12 more more RBR en-wikipedia-org-43 65 13 effective effective JJ en-wikipedia-org-43 65 14 in in IN en-wikipedia-org-43 65 15 the the DT en-wikipedia-org-43 65 16 absence absence NN en-wikipedia-org-43 65 17 of of IN en-wikipedia-org-43 65 18 Trk Trk NNP en-wikipedia-org-43 65 19 receptors receptor NNS en-wikipedia-org-43 65 20 due due IN en-wikipedia-org-43 65 21 to to IN en-wikipedia-org-43 65 22 the the DT en-wikipedia-org-43 65 23 fact fact NN en-wikipedia-org-43 65 24 that that IN en-wikipedia-org-43 65 25 activated activate VBD en-wikipedia-org-43 65 26 Trk Trk NNP en-wikipedia-org-43 65 27 receptors receptor NNS en-wikipedia-org-43 65 28 suppress suppress VBP en-wikipedia-org-43 65 29 the the DT en-wikipedia-org-43 65 30 JNK JNK NNP en-wikipedia-org-43 65 31 cascade cascade NN en-wikipedia-org-43 65 32 . . . en-wikipedia-org-43 66 1 [ [ -LRB- en-wikipedia-org-43 66 2 29][31 29][31 LS en-wikipedia-org-43 66 3 ] ] -RRB- en-wikipedia-org-43 66 4 The the DT en-wikipedia-org-43 66 5 expression expression NN en-wikipedia-org-43 66 6 of of IN en-wikipedia-org-43 66 7 TrkA TrkA NNP en-wikipedia-org-43 66 8 or or CC en-wikipedia-org-43 66 9 TrkC TrkC NNP en-wikipedia-org-43 66 10 receptors receptor NNS en-wikipedia-org-43 66 11 in in IN en-wikipedia-org-43 66 12 the the DT en-wikipedia-org-43 66 13 absence absence NN en-wikipedia-org-43 66 14 of of IN en-wikipedia-org-43 66 15 neurotrophins neurotrophin NNS en-wikipedia-org-43 66 16 can can MD en-wikipedia-org-43 66 17 lead lead VB en-wikipedia-org-43 66 18 to to IN en-wikipedia-org-43 66 19 apoptosis apoptosis NN en-wikipedia-org-43 66 20 , , , en-wikipedia-org-43 66 21 but but CC en-wikipedia-org-43 66 22 the the DT en-wikipedia-org-43 66 23 mechanism mechanism NN en-wikipedia-org-43 66 24 is be VBZ en-wikipedia-org-43 66 25 poorly poorly RB en-wikipedia-org-43 66 26 understood understand VBN en-wikipedia-org-43 66 27 . . . en-wikipedia-org-43 67 1 [ [ -LRB- en-wikipedia-org-43 67 2 32 32 CD en-wikipedia-org-43 67 3 ] ] -RRB- en-wikipedia-org-43 67 4 The the DT en-wikipedia-org-43 67 5 addition addition NN en-wikipedia-org-43 67 6 of of IN en-wikipedia-org-43 67 7 NGF NGF NNP en-wikipedia-org-43 67 8 ( ( -LRB- en-wikipedia-org-43 67 9 for for IN en-wikipedia-org-43 67 10 TrkA TrkA NNP en-wikipedia-org-43 67 11 ) ) -RRB- en-wikipedia-org-43 67 12 or or CC en-wikipedia-org-43 67 13 NT-3 NT-3 NNP en-wikipedia-org-43 67 14 ( ( -LRB- en-wikipedia-org-43 67 15 for for IN en-wikipedia-org-43 67 16 TrkC TrkC NNP en-wikipedia-org-43 67 17 ) ) -RRB- en-wikipedia-org-43 67 18 prevents prevent VBZ en-wikipedia-org-43 67 19 this this DT en-wikipedia-org-43 67 20 apoptosis apoptosis NN en-wikipedia-org-43 67 21 . . . en-wikipedia-org-43 68 1 [ [ -LRB- en-wikipedia-org-43 68 2 32 32 CD en-wikipedia-org-43 68 3 ] ] -RRB- en-wikipedia-org-43 68 4 For for IN en-wikipedia-org-43 68 5 this this DT en-wikipedia-org-43 68 6 reason reason NN en-wikipedia-org-43 68 7 TrkA TrkA NNP en-wikipedia-org-43 68 8 and and CC en-wikipedia-org-43 68 9 TrkC TrkC NNP en-wikipedia-org-43 68 10 are be VBP en-wikipedia-org-43 68 11 referred refer VBN en-wikipedia-org-43 68 12 to to IN en-wikipedia-org-43 68 13 as as IN en-wikipedia-org-43 68 14 dependence dependence NN en-wikipedia-org-43 68 15 receptors receptor NNS en-wikipedia-org-43 68 16 , , , en-wikipedia-org-43 68 17 because because IN en-wikipedia-org-43 68 18 whether whether IN en-wikipedia-org-43 68 19 they -PRON- PRP en-wikipedia-org-43 68 20 induce induce VBP en-wikipedia-org-43 68 21 apoptosis apoptosis NN en-wikipedia-org-43 68 22 or or CC en-wikipedia-org-43 68 23 survival survival NN en-wikipedia-org-43 68 24 is be VBZ en-wikipedia-org-43 68 25 dependent dependent JJ en-wikipedia-org-43 68 26 on on IN en-wikipedia-org-43 68 27 the the DT en-wikipedia-org-43 68 28 presence presence NN en-wikipedia-org-43 68 29 of of IN en-wikipedia-org-43 68 30 neurotrophins neurotrophin NNS en-wikipedia-org-43 68 31 . . . en-wikipedia-org-43 69 1 [ [ -LRB- en-wikipedia-org-43 69 2 23][33 23][33 LS en-wikipedia-org-43 69 3 ] ] -RRB- en-wikipedia-org-43 69 4 The the DT en-wikipedia-org-43 69 5 expression expression NN en-wikipedia-org-43 69 6 of of IN en-wikipedia-org-43 69 7 TrkB TrkB NNP en-wikipedia-org-43 69 8 , , , en-wikipedia-org-43 69 9 which which WDT en-wikipedia-org-43 69 10 is be VBZ en-wikipedia-org-43 69 11 found find VBN en-wikipedia-org-43 69 12 mainly mainly RB en-wikipedia-org-43 69 13 in in IN en-wikipedia-org-43 69 14 the the DT en-wikipedia-org-43 69 15 CNS CNS NNP en-wikipedia-org-43 69 16 , , , en-wikipedia-org-43 69 17 does do VBZ en-wikipedia-org-43 69 18 not not RB en-wikipedia-org-43 69 19 cause cause VB en-wikipedia-org-43 69 20 apoptosis apoptosis NN en-wikipedia-org-43 69 21 . . . en-wikipedia-org-43 70 1 [ [ -LRB- en-wikipedia-org-43 70 2 23 23 CD en-wikipedia-org-43 70 3 ] ] -RRB- en-wikipedia-org-43 70 4 This this DT en-wikipedia-org-43 70 5 is be VBZ en-wikipedia-org-43 70 6 thought think VBN en-wikipedia-org-43 70 7 to to TO en-wikipedia-org-43 70 8 be be VB en-wikipedia-org-43 70 9 because because IN en-wikipedia-org-43 70 10 it -PRON- PRP en-wikipedia-org-43 70 11 is be VBZ en-wikipedia-org-43 70 12 differentially differentially RB en-wikipedia-org-43 70 13 located locate VBN en-wikipedia-org-43 70 14 in in IN en-wikipedia-org-43 70 15 the the DT en-wikipedia-org-43 70 16 cell cell NN en-wikipedia-org-43 70 17 membrane membrane NN en-wikipedia-org-43 70 18 while while IN en-wikipedia-org-43 70 19 TrkA TrkA NNP en-wikipedia-org-43 70 20 and and CC en-wikipedia-org-43 70 21 TrkC TrkC NNP en-wikipedia-org-43 70 22 are be VBP en-wikipedia-org-43 70 23 co co VBN en-wikipedia-org-43 70 24 - - VBN en-wikipedia-org-43 70 25 localized localize VBN en-wikipedia-org-43 70 26 with with IN en-wikipedia-org-43 70 27 p75NTR p75ntr NN en-wikipedia-org-43 70 28 in in IN en-wikipedia-org-43 70 29 lipid lipid NN en-wikipedia-org-43 70 30 rafts raft NNS en-wikipedia-org-43 70 31 . . . en-wikipedia-org-43 71 1 [ [ -LRB- en-wikipedia-org-43 71 2 23][32 23][32 CD en-wikipedia-org-43 71 3 ] ] -RRB- en-wikipedia-org-43 71 4 In in IN en-wikipedia-org-43 71 5 the the DT en-wikipedia-org-43 71 6 PNS PNS NNP en-wikipedia-org-43 71 7 ( ( -LRB- en-wikipedia-org-43 71 8 where where WRB en-wikipedia-org-43 71 9 NGF NGF NNP en-wikipedia-org-43 71 10 , , , en-wikipedia-org-43 71 11 NT-3 NT-3 NNP en-wikipedia-org-43 71 12 and and CC en-wikipedia-org-43 71 13 NT-4 NT-4 NNP en-wikipedia-org-43 71 14 are be VBP en-wikipedia-org-43 71 15 mainly mainly RB en-wikipedia-org-43 71 16 secreted secrete VBN en-wikipedia-org-43 71 17 ) ) -RRB- en-wikipedia-org-43 71 18 cell cell NN en-wikipedia-org-43 71 19 fate fate NN en-wikipedia-org-43 71 20 is be VBZ en-wikipedia-org-43 71 21 determined determine VBN en-wikipedia-org-43 71 22 by by IN en-wikipedia-org-43 71 23 a a DT en-wikipedia-org-43 71 24 single single JJ en-wikipedia-org-43 71 25 growth growth NN en-wikipedia-org-43 71 26 factor factor NN en-wikipedia-org-43 71 27 ( ( -LRB- en-wikipedia-org-43 71 28 i.e. i.e. FW en-wikipedia-org-43 72 1 neurotrophins neurotrophins NNP en-wikipedia-org-43 72 2 ) ) -RRB- en-wikipedia-org-43 72 3 . . . en-wikipedia-org-43 73 1 [ [ -LRB- en-wikipedia-org-43 73 2 25][33 25][33 CD en-wikipedia-org-43 73 3 ] ] -RRB- en-wikipedia-org-43 73 4 However however RB en-wikipedia-org-43 73 5 , , , en-wikipedia-org-43 73 6 in in IN en-wikipedia-org-43 73 7 the the DT en-wikipedia-org-43 73 8 CNS CNS NNP en-wikipedia-org-43 73 9 ( ( -LRB- en-wikipedia-org-43 73 10 where where WRB en-wikipedia-org-43 73 11 BDNF BDNF NNP en-wikipedia-org-43 73 12 is be VBZ en-wikipedia-org-43 73 13 mainly mainly RB en-wikipedia-org-43 73 14 secreted secrete VBN en-wikipedia-org-43 73 15 in in IN en-wikipedia-org-43 73 16 the the DT en-wikipedia-org-43 73 17 spinal spinal JJ en-wikipedia-org-43 73 18 cord cord NN en-wikipedia-org-43 73 19 , , , en-wikipedia-org-43 73 20 substantia substantia NNP en-wikipedia-org-43 73 21 nigra nigra NNP en-wikipedia-org-43 73 22 , , , en-wikipedia-org-43 73 23 amygdala amygdala NNP en-wikipedia-org-43 73 24 , , , en-wikipedia-org-43 73 25 hypothalamus hypothalamus NNP en-wikipedia-org-43 73 26 , , , en-wikipedia-org-43 73 27 cerebellum cerebellum NN en-wikipedia-org-43 73 28 , , , en-wikipedia-org-43 73 29 hippocampus hippocampus NNP en-wikipedia-org-43 73 30 and and CC en-wikipedia-org-43 73 31 cortex cortex NNP en-wikipedia-org-43 73 32 ) ) -RRB- en-wikipedia-org-43 73 33 more more JJR en-wikipedia-org-43 73 34 factors factor NNS en-wikipedia-org-43 73 35 determine determine VBP en-wikipedia-org-43 73 36 cell cell NN en-wikipedia-org-43 73 37 fate fate NN en-wikipedia-org-43 73 38 , , , en-wikipedia-org-43 73 39 including include VBG en-wikipedia-org-43 73 40 neural neural JJ en-wikipedia-org-43 73 41 activity activity NN en-wikipedia-org-43 73 42 and and CC en-wikipedia-org-43 73 43 neurotransmitter neurotransmitter NN en-wikipedia-org-43 73 44 input input NN en-wikipedia-org-43 73 45 . . . en-wikipedia-org-43 74 1 [ [ -LRB- en-wikipedia-org-43 74 2 25][33 25][33 CD en-wikipedia-org-43 74 3 ] ] -RRB- en-wikipedia-org-43 74 4 Neurotrophins Neurotrophins NNP en-wikipedia-org-43 74 5 in in IN en-wikipedia-org-43 74 6 the the DT en-wikipedia-org-43 74 7 CNS CNS NNP en-wikipedia-org-43 74 8 have have VBP en-wikipedia-org-43 74 9 also also RB en-wikipedia-org-43 74 10 been be VBN en-wikipedia-org-43 74 11 shown show VBN en-wikipedia-org-43 74 12 to to TO en-wikipedia-org-43 74 13 play play VB en-wikipedia-org-43 74 14 a a DT en-wikipedia-org-43 74 15 more more RBR en-wikipedia-org-43 74 16 important important JJ en-wikipedia-org-43 74 17 role role NN en-wikipedia-org-43 74 18 in in IN en-wikipedia-org-43 74 19 neural neural JJ en-wikipedia-org-43 74 20 cell cell NN en-wikipedia-org-43 74 21 differentiation differentiation NN en-wikipedia-org-43 74 22 and and CC en-wikipedia-org-43 74 23 function function NN en-wikipedia-org-43 74 24 rather rather RB en-wikipedia-org-43 74 25 than than IN en-wikipedia-org-43 74 26 survival survival NN en-wikipedia-org-43 74 27 . . . en-wikipedia-org-43 75 1 [ [ -LRB- en-wikipedia-org-43 75 2 33 33 CD en-wikipedia-org-43 75 3 ] ] -RRB- en-wikipedia-org-43 75 4 For for IN en-wikipedia-org-43 75 5 these these DT en-wikipedia-org-43 75 6 reasons reason NNS en-wikipedia-org-43 75 7 , , , en-wikipedia-org-43 75 8 compared compare VBN en-wikipedia-org-43 75 9 to to IN en-wikipedia-org-43 75 10 neurons neuron NNS en-wikipedia-org-43 75 11 in in IN en-wikipedia-org-43 75 12 the the DT en-wikipedia-org-43 75 13 PNS PNS NNP en-wikipedia-org-43 75 14 , , , en-wikipedia-org-43 75 15 neurons neuron NNS en-wikipedia-org-43 75 16 of of IN en-wikipedia-org-43 75 17 the the DT en-wikipedia-org-43 75 18 CNS CNS NNP en-wikipedia-org-43 75 19 are be VBP en-wikipedia-org-43 75 20 less less RBR en-wikipedia-org-43 75 21 sensitive sensitive JJ en-wikipedia-org-43 75 22 to to IN en-wikipedia-org-43 75 23 the the DT en-wikipedia-org-43 75 24 absence absence NN en-wikipedia-org-43 75 25 of of IN en-wikipedia-org-43 75 26 a a DT en-wikipedia-org-43 75 27 single single JJ en-wikipedia-org-43 75 28 neurotrophin neurotrophin NN en-wikipedia-org-43 75 29 or or CC en-wikipedia-org-43 75 30 neurotrophin neurotrophin JJ en-wikipedia-org-43 75 31 receptor receptor NN en-wikipedia-org-43 75 32 during during IN en-wikipedia-org-43 75 33 development development NN en-wikipedia-org-43 75 34 ; ; : en-wikipedia-org-43 75 35 with with IN en-wikipedia-org-43 75 36 the the DT en-wikipedia-org-43 75 37 exception exception NN en-wikipedia-org-43 75 38 being be VBG en-wikipedia-org-43 75 39 neurons neuron NNS en-wikipedia-org-43 75 40 in in IN en-wikipedia-org-43 75 41 the the DT en-wikipedia-org-43 75 42 thalamus thalamus NN en-wikipedia-org-43 75 43 and and CC en-wikipedia-org-43 75 44 substantia substantia NNP en-wikipedia-org-43 75 45 nigra nigra NNP en-wikipedia-org-43 75 46 . . . en-wikipedia-org-43 76 1 [ [ -LRB- en-wikipedia-org-43 76 2 23 23 CD en-wikipedia-org-43 76 3 ] ] -RRB- en-wikipedia-org-43 76 4 Gene gene NN en-wikipedia-org-43 76 5 knockout knockout NN en-wikipedia-org-43 76 6 experiments experiment NNS en-wikipedia-org-43 76 7 were be VBD en-wikipedia-org-43 76 8 conducted conduct VBN en-wikipedia-org-43 76 9 to to TO en-wikipedia-org-43 76 10 identify identify VB en-wikipedia-org-43 76 11 the the DT en-wikipedia-org-43 76 12 neuronal neuronal JJ en-wikipedia-org-43 76 13 populations population NNS en-wikipedia-org-43 76 14 in in IN en-wikipedia-org-43 76 15 both both DT en-wikipedia-org-43 76 16 the the DT en-wikipedia-org-43 76 17 PNS PNS NNP en-wikipedia-org-43 76 18 and and CC en-wikipedia-org-43 76 19 CNS CNS NNP en-wikipedia-org-43 76 20 that that WDT en-wikipedia-org-43 76 21 were be VBD en-wikipedia-org-43 76 22 affected affect VBN en-wikipedia-org-43 76 23 by by IN en-wikipedia-org-43 76 24 the the DT en-wikipedia-org-43 76 25 loss loss NN en-wikipedia-org-43 76 26 of of IN en-wikipedia-org-43 76 27 different different JJ en-wikipedia-org-43 76 28 neurotrophins neurotrophin NNS en-wikipedia-org-43 76 29 during during IN en-wikipedia-org-43 76 30 development development NN en-wikipedia-org-43 76 31 and and CC en-wikipedia-org-43 76 32 the the DT en-wikipedia-org-43 76 33 extent extent NN en-wikipedia-org-43 76 34 to to TO en-wikipedia-org-43 76 35 which which WDT en-wikipedia-org-43 76 36 these these DT en-wikipedia-org-43 76 37 populations population NNS en-wikipedia-org-43 76 38 were be VBD en-wikipedia-org-43 76 39 affected affect VBN en-wikipedia-org-43 76 40 . . . en-wikipedia-org-43 77 1 [ [ -LRB- en-wikipedia-org-43 77 2 23 23 CD en-wikipedia-org-43 77 3 ] ] -RRB- en-wikipedia-org-43 77 4 These these DT en-wikipedia-org-43 77 5 knockout knockout JJ en-wikipedia-org-43 77 6 experiments experiment NNS en-wikipedia-org-43 77 7 resulted result VBD en-wikipedia-org-43 77 8 in in IN en-wikipedia-org-43 77 9 the the DT en-wikipedia-org-43 77 10 loss loss NN en-wikipedia-org-43 77 11 of of IN en-wikipedia-org-43 77 12 several several JJ en-wikipedia-org-43 77 13 neuron neuron NN en-wikipedia-org-43 77 14 populations population NNS en-wikipedia-org-43 77 15 including include VBG en-wikipedia-org-43 77 16 the the DT en-wikipedia-org-43 77 17 retina retina NNP en-wikipedia-org-43 77 18 , , , en-wikipedia-org-43 77 19 cholinergic cholinergic JJ en-wikipedia-org-43 77 20 brainstem brainstem NNP en-wikipedia-org-43 77 21 and and CC en-wikipedia-org-43 77 22 the the DT en-wikipedia-org-43 77 23 spinal spinal JJ en-wikipedia-org-43 77 24 cord cord NN en-wikipedia-org-43 77 25 . . . en-wikipedia-org-43 78 1 [ [ -LRB- en-wikipedia-org-43 78 2 23][25 23][25 CD en-wikipedia-org-43 78 3 ] ] -RRB- en-wikipedia-org-43 78 4 It -PRON- PRP en-wikipedia-org-43 78 5 was be VBD en-wikipedia-org-43 78 6 found find VBN en-wikipedia-org-43 78 7 that that IN en-wikipedia-org-43 78 8 NGF NGF NNP en-wikipedia-org-43 78 9 - - HYPH en-wikipedia-org-43 78 10 knockout knockout NN en-wikipedia-org-43 78 11 mice mouse NNS en-wikipedia-org-43 78 12 had have VBD en-wikipedia-org-43 78 13 losses loss NNS en-wikipedia-org-43 78 14 of of IN en-wikipedia-org-43 78 15 a a DT en-wikipedia-org-43 78 16 majority majority NN en-wikipedia-org-43 78 17 of of IN en-wikipedia-org-43 78 18 their -PRON- PRP$ en-wikipedia-org-43 78 19 dorsal dorsal NN en-wikipedia-org-43 78 20 root root NN en-wikipedia-org-43 78 21 ganglia ganglia NN en-wikipedia-org-43 78 22 ( ( -LRB- en-wikipedia-org-43 78 23 DRG DRG NNP en-wikipedia-org-43 78 24 ) ) -RRB- en-wikipedia-org-43 78 25 , , , en-wikipedia-org-43 78 26 trigeminal trigeminal JJ en-wikipedia-org-43 78 27 ganglia ganglia NNP en-wikipedia-org-43 78 28 and and CC en-wikipedia-org-43 78 29 superior superior NNP en-wikipedia-org-43 78 30 cervical cervical NNP en-wikipedia-org-43 78 31 ganglia ganglia NN en-wikipedia-org-43 78 32 . . . en-wikipedia-org-43 79 1 [ [ -LRB- en-wikipedia-org-43 79 2 23][29 23][29 CD en-wikipedia-org-43 79 3 ] ] -RRB- en-wikipedia-org-43 79 4 The the DT en-wikipedia-org-43 79 5 viability viability NN en-wikipedia-org-43 79 6 of of IN en-wikipedia-org-43 79 7 these these DT en-wikipedia-org-43 79 8 mice mouse NNS en-wikipedia-org-43 79 9 was be VBD en-wikipedia-org-43 79 10 poor poor JJ en-wikipedia-org-43 79 11 . . . en-wikipedia-org-43 80 1 [ [ -LRB- en-wikipedia-org-43 80 2 23 23 CD en-wikipedia-org-43 80 3 ] ] -RRB- en-wikipedia-org-43 80 4 The the DT en-wikipedia-org-43 80 5 BDNF BDNF NNP en-wikipedia-org-43 80 6 - - HYPH en-wikipedia-org-43 80 7 knockout knockout NN en-wikipedia-org-43 80 8 mice mouse NNS en-wikipedia-org-43 80 9 had have VBD en-wikipedia-org-43 80 10 losses loss NNS en-wikipedia-org-43 80 11 of of IN en-wikipedia-org-43 80 12 a a DT en-wikipedia-org-43 80 13 majority majority NN en-wikipedia-org-43 80 14 of of IN en-wikipedia-org-43 80 15 their -PRON- PRP$ en-wikipedia-org-43 80 16 vestibular vestibular JJ en-wikipedia-org-43 80 17 ganglia ganglia NN en-wikipedia-org-43 80 18 and and CC en-wikipedia-org-43 80 19 moderate moderate JJ en-wikipedia-org-43 80 20 losses loss NNS en-wikipedia-org-43 80 21 of of IN en-wikipedia-org-43 80 22 their -PRON- PRP$ en-wikipedia-org-43 80 23 DRG,[34 DRG,[34 NNP en-wikipedia-org-43 80 24 ] ] -RRB- en-wikipedia-org-43 80 25 trigeminal trigeminal JJ en-wikipedia-org-43 80 26 ganglia ganglia NNP en-wikipedia-org-43 80 27 , , , en-wikipedia-org-43 80 28 nodose nodose NNP en-wikipedia-org-43 80 29 petrosal petrosal NNP en-wikipedia-org-43 80 30 ganglia ganglia NNP en-wikipedia-org-43 80 31 and and CC en-wikipedia-org-43 80 32 cochlear cochlear JJ en-wikipedia-org-43 80 33 ganglia ganglia NNP en-wikipedia-org-43 80 34 . . . en-wikipedia-org-43 81 1 [ [ -LRB- en-wikipedia-org-43 81 2 23][29 23][29 CD en-wikipedia-org-43 81 3 ] ] -RRB- en-wikipedia-org-43 81 4 In in IN en-wikipedia-org-43 81 5 addition addition NN en-wikipedia-org-43 81 6 they -PRON- PRP en-wikipedia-org-43 81 7 also also RB en-wikipedia-org-43 81 8 had have VBD en-wikipedia-org-43 81 9 minor minor JJ en-wikipedia-org-43 81 10 losses loss NNS en-wikipedia-org-43 81 11 of of IN en-wikipedia-org-43 81 12 their -PRON- PRP$ en-wikipedia-org-43 81 13 facial facial JJ en-wikipedia-org-43 81 14 motoneurons motoneuron NNS en-wikipedia-org-43 81 15 located locate VBN en-wikipedia-org-43 81 16 in in IN en-wikipedia-org-43 81 17 the the DT en-wikipedia-org-43 81 18 CNS CNS NNP en-wikipedia-org-43 81 19 . . . en-wikipedia-org-43 82 1 [ [ -LRB- en-wikipedia-org-43 82 2 23][29 23][29 CD en-wikipedia-org-43 82 3 ] ] -RRB- en-wikipedia-org-43 82 4 The the DT en-wikipedia-org-43 82 5 viability viability NN en-wikipedia-org-43 82 6 of of IN en-wikipedia-org-43 82 7 these these DT en-wikipedia-org-43 82 8 mice mouse NNS en-wikipedia-org-43 82 9 was be VBD en-wikipedia-org-43 82 10 moderate moderate JJ en-wikipedia-org-43 82 11 . . . en-wikipedia-org-43 83 1 [ [ -LRB- en-wikipedia-org-43 83 2 23 23 CD en-wikipedia-org-43 83 3 ] ] -RRB- en-wikipedia-org-43 83 4 The the DT en-wikipedia-org-43 83 5 NT-4-knockout NT-4-knockout `` en-wikipedia-org-43 83 6 mice mouse NNS en-wikipedia-org-43 83 7 had have VBD en-wikipedia-org-43 83 8 moderate moderate JJ en-wikipedia-org-43 83 9 losses loss NNS en-wikipedia-org-43 83 10 of of IN en-wikipedia-org-43 83 11 their -PRON- PRP$ en-wikipedia-org-43 83 12 nodose nodose NNP en-wikipedia-org-43 83 13 petrosal petrosal NN en-wikipedia-org-43 83 14 ganglia ganglia NNP en-wikipedia-org-43 83 15 and and CC en-wikipedia-org-43 83 16 minor minor JJ en-wikipedia-org-43 83 17 losses loss NNS en-wikipedia-org-43 83 18 of of IN en-wikipedia-org-43 83 19 their -PRON- PRP$ en-wikipedia-org-43 83 20 DRG drg NN en-wikipedia-org-43 83 21 , , , en-wikipedia-org-43 83 22 trigeminal trigeminal JJ en-wikipedia-org-43 83 23 ganglia ganglia NNP en-wikipedia-org-43 83 24 and and CC en-wikipedia-org-43 83 25 vestibular vestibular JJ en-wikipedia-org-43 83 26 ganglia ganglia NNP en-wikipedia-org-43 83 27 . . . en-wikipedia-org-43 84 1 [ [ -LRB- en-wikipedia-org-43 84 2 23][29 23][29 CD en-wikipedia-org-43 84 3 ] ] -RRB- en-wikipedia-org-43 84 4 The the DT en-wikipedia-org-43 84 5 NT-4-knockout NT-4-knockout '' en-wikipedia-org-43 84 6 mice mouse NNS en-wikipedia-org-43 84 7 also also RB en-wikipedia-org-43 84 8 had have VBD en-wikipedia-org-43 84 9 minor minor JJ en-wikipedia-org-43 84 10 losses loss NNS en-wikipedia-org-43 84 11 of of IN en-wikipedia-org-43 84 12 facial facial JJ en-wikipedia-org-43 84 13 motoneurons motoneuron NNS en-wikipedia-org-43 84 14 . . . en-wikipedia-org-43 85 1 [ [ -LRB- en-wikipedia-org-43 85 2 23][29 23][29 CD en-wikipedia-org-43 85 3 ] ] -RRB- en-wikipedia-org-43 85 4 These these DT en-wikipedia-org-43 85 5 mice mouse NNS en-wikipedia-org-43 85 6 were be VBD en-wikipedia-org-43 85 7 very very RB en-wikipedia-org-43 85 8 viable viable JJ en-wikipedia-org-43 85 9 . . . en-wikipedia-org-43 86 1 [ [ -LRB- en-wikipedia-org-43 86 2 23 23 CD en-wikipedia-org-43 86 3 ] ] -RRB- en-wikipedia-org-43 86 4 The the DT en-wikipedia-org-43 86 5 NT-3 nt-3 JJ en-wikipedia-org-43 86 6 knockout knockout NN en-wikipedia-org-43 86 7 mice mouse NNS en-wikipedia-org-43 86 8 had have VBD en-wikipedia-org-43 86 9 losses loss NNS en-wikipedia-org-43 86 10 of of IN en-wikipedia-org-43 86 11 a a DT en-wikipedia-org-43 86 12 majority majority NN en-wikipedia-org-43 86 13 of of IN en-wikipedia-org-43 86 14 their -PRON- PRP$ en-wikipedia-org-43 86 15 DRG drg NN en-wikipedia-org-43 86 16 , , , en-wikipedia-org-43 86 17 trigeminal trigeminal JJ en-wikipedia-org-43 86 18 ganglia ganglia NNP en-wikipedia-org-43 86 19 , , , en-wikipedia-org-43 86 20 cochlear cochlear JJ en-wikipedia-org-43 86 21 ganglia ganglia NNP en-wikipedia-org-43 86 22 and and CC en-wikipedia-org-43 86 23 superior superior JJ en-wikipedia-org-43 86 24 cervival cervival NNP en-wikipedia-org-43 86 25 ganglia ganglia NNP en-wikipedia-org-43 86 26 and and CC en-wikipedia-org-43 86 27 moderate moderate JJ en-wikipedia-org-43 86 28 losses loss NNS en-wikipedia-org-43 86 29 of of IN en-wikipedia-org-43 86 30 nodose nodose NNP en-wikipedia-org-43 86 31 petrosal petrosal NNP en-wikipedia-org-43 86 32 ganglia ganglia NNP en-wikipedia-org-43 86 33 and and CC en-wikipedia-org-43 86 34 vestibular vestibular JJ en-wikipedia-org-43 86 35 ganglia ganglia NNP en-wikipedia-org-43 86 36 . . . en-wikipedia-org-43 87 1 [ [ -LRB- en-wikipedia-org-43 87 2 23][29 23][29 CD en-wikipedia-org-43 87 3 ] ] -RRB- en-wikipedia-org-43 87 4 In in IN en-wikipedia-org-43 87 5 addition addition NN en-wikipedia-org-43 87 6 the the DT en-wikipedia-org-43 87 7 NT-3-knockout NT-3-knockout `` en-wikipedia-org-43 87 8 mice mouse NNS en-wikipedia-org-43 87 9 had have VBD en-wikipedia-org-43 87 10 moderate moderate JJ en-wikipedia-org-43 87 11 losses loss NNS en-wikipedia-org-43 87 12 of of IN en-wikipedia-org-43 87 13 spinal spinal JJ en-wikipedia-org-43 87 14 moroneurons moroneuron NNS en-wikipedia-org-43 87 15 . . . en-wikipedia-org-43 88 1 [ [ -LRB- en-wikipedia-org-43 88 2 23][29 23][29 CD en-wikipedia-org-43 88 3 ] ] -RRB- en-wikipedia-org-43 88 4 These these DT en-wikipedia-org-43 88 5 mice mouse NNS en-wikipedia-org-43 88 6 had have VBD en-wikipedia-org-43 88 7 very very RB en-wikipedia-org-43 88 8 poor poor JJ en-wikipedia-org-43 88 9 viability viability NN en-wikipedia-org-43 88 10 . . . en-wikipedia-org-43 89 1 [ [ -LRB- en-wikipedia-org-43 89 2 23 23 CD en-wikipedia-org-43 89 3 ] ] -RRB- en-wikipedia-org-43 89 4 These these DT en-wikipedia-org-43 89 5 results result NNS en-wikipedia-org-43 89 6 show show VBP en-wikipedia-org-43 89 7 that that IN en-wikipedia-org-43 89 8 the the DT en-wikipedia-org-43 89 9 absence absence NN en-wikipedia-org-43 89 10 of of IN en-wikipedia-org-43 89 11 different different JJ en-wikipedia-org-43 89 12 neurotrophins neurotrophin NNS en-wikipedia-org-43 89 13 result result VBP en-wikipedia-org-43 89 14 in in IN en-wikipedia-org-43 89 15 losses loss NNS en-wikipedia-org-43 89 16 of of IN en-wikipedia-org-43 89 17 different different JJ en-wikipedia-org-43 89 18 neuron neuron NN en-wikipedia-org-43 89 19 populations population NNS en-wikipedia-org-43 89 20 ( ( -LRB- en-wikipedia-org-43 89 21 mainly mainly RB en-wikipedia-org-43 89 22 in in IN en-wikipedia-org-43 89 23 the the DT en-wikipedia-org-43 89 24 PNS PNS NNP en-wikipedia-org-43 89 25 ) ) -RRB- en-wikipedia-org-43 89 26 . . . en-wikipedia-org-43 90 1 [ [ -LRB- en-wikipedia-org-43 90 2 23 23 CD en-wikipedia-org-43 90 3 ] ] -RRB- en-wikipedia-org-43 90 4 Furthermore furthermore RB en-wikipedia-org-43 90 5 , , , en-wikipedia-org-43 90 6 the the DT en-wikipedia-org-43 90 7 absence absence NN en-wikipedia-org-43 90 8 of of IN en-wikipedia-org-43 90 9 the the DT en-wikipedia-org-43 90 10 neurotrophin neurotrophin JJ en-wikipedia-org-43 90 11 survival survival NN en-wikipedia-org-43 90 12 signal signal NN en-wikipedia-org-43 90 13 leads lead VBZ en-wikipedia-org-43 90 14 to to IN en-wikipedia-org-43 90 15 apoptosis apoptosis NN en-wikipedia-org-43 90 16 . . . en-wikipedia-org-43 91 1 [ [ -LRB- en-wikipedia-org-43 91 2 23 23 CD en-wikipedia-org-43 91 3 ] ] -RRB- en-wikipedia-org-43 91 4 See see VB en-wikipedia-org-43 91 5 also[edit also[edit CD en-wikipedia-org-43 91 6 ] ] -RRB- en-wikipedia-org-43 91 7 Neurotrophic neurotrophic JJ en-wikipedia-org-43 91 8 electrode electrode NN en-wikipedia-org-43 91 9 Neuron Neuron NNP en-wikipedia-org-43 91 10 Programmed Programmed NNP en-wikipedia-org-43 91 11 cell cell NN en-wikipedia-org-43 91 12 death death NN en-wikipedia-org-43 91 13 References[edit references[edit NN en-wikipedia-org-43 91 14 ] ] -RRB- en-wikipedia-org-43 91 15 ^ ^ . en-wikipedia-org-43 91 16 Hempstead Hempstead NNP en-wikipedia-org-43 91 17 BL BL NNP en-wikipedia-org-43 91 18 ( ( -LRB- en-wikipedia-org-43 91 19 February February NNP en-wikipedia-org-43 91 20 2006 2006 CD en-wikipedia-org-43 91 21 ) ) -RRB- en-wikipedia-org-43 91 22 . . . en-wikipedia-org-43 92 1 " " `` en-wikipedia-org-43 92 2 Dissecting dissect VBG en-wikipedia-org-43 92 3 the the DT en-wikipedia-org-43 92 4 diverse diverse JJ en-wikipedia-org-43 92 5 actions action NNS en-wikipedia-org-43 92 6 of of IN en-wikipedia-org-43 92 7 pro- pro- NN en-wikipedia-org-43 92 8 and and CC en-wikipedia-org-43 92 9 mature mature JJ en-wikipedia-org-43 92 10 neurotrophins neurotrophin NNS en-wikipedia-org-43 92 11 " " '' en-wikipedia-org-43 92 12 . . . en-wikipedia-org-43 93 1 Current Current NNP en-wikipedia-org-43 93 2 Alzheimer Alzheimer NNP en-wikipedia-org-43 93 3 Research Research NNP en-wikipedia-org-43 93 4 . . . en-wikipedia-org-43 94 1 3 3 CD en-wikipedia-org-43 94 2 ( ( -LRB- en-wikipedia-org-43 94 3 1 1 CD en-wikipedia-org-43 94 4 ) ) -RRB- en-wikipedia-org-43 94 5 : : : en-wikipedia-org-43 94 6 19–24 19–24 LS en-wikipedia-org-43 94 7 . . . en-wikipedia-org-43 95 1 doi:10.2174/156720506775697061 doi:10.2174/156720506775697061 NNP en-wikipedia-org-43 95 2 . . . en-wikipedia-org-43 96 1 PMID PMID NNP en-wikipedia-org-43 96 2   _SP en-wikipedia-org-43 96 3 16472198 16472198 CD en-wikipedia-org-43 96 4 . . . en-wikipedia-org-43 97 1 Archived archived JJ en-wikipedia-org-43 97 2 from from IN en-wikipedia-org-43 97 3 the the DT en-wikipedia-org-43 97 4 original original NN en-wikipedia-org-43 97 5 on on IN en-wikipedia-org-43 97 6 2009 2009 CD en-wikipedia-org-43 97 7 - - SYM en-wikipedia-org-43 97 8 08 08 CD en-wikipedia-org-43 97 9 - - SYM en-wikipedia-org-43 97 10 30 30 CD en-wikipedia-org-43 97 11 . . . en-wikipedia-org-43 98 1 Retrieved retrieve VBN en-wikipedia-org-43 98 2 2020 2020 CD en-wikipedia-org-43 98 3 - - HYPH en-wikipedia-org-43 98 4 04 04 CD en-wikipedia-org-43 98 5 - - HYPH en-wikipedia-org-43 98 6 16 16 CD en-wikipedia-org-43 98 7 . . . en-wikipedia-org-43 99 1 ^ ^ NFP en-wikipedia-org-43 99 2 Reichardt Reichardt NNP en-wikipedia-org-43 99 3 LF LF NNP en-wikipedia-org-43 99 4 ( ( -LRB- en-wikipedia-org-43 99 5 September September NNP en-wikipedia-org-43 99 6 2006 2006 CD en-wikipedia-org-43 99 7 ) ) -RRB- en-wikipedia-org-43 99 8 . . . en-wikipedia-org-43 100 1 " " `` en-wikipedia-org-43 100 2 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 100 3 - - HYPH en-wikipedia-org-43 100 4 regulated regulated JJ en-wikipedia-org-43 100 5 signalling signalling NN en-wikipedia-org-43 100 6 pathways pathway NNS en-wikipedia-org-43 100 7 " " '' en-wikipedia-org-43 100 8 . . . en-wikipedia-org-43 101 1 Philosophical philosophical JJ en-wikipedia-org-43 101 2 Transactions Transactions NNPS en-wikipedia-org-43 101 3 of of IN en-wikipedia-org-43 101 4 the the DT en-wikipedia-org-43 101 5 Royal Royal NNP en-wikipedia-org-43 101 6 Society Society NNP en-wikipedia-org-43 101 7 of of IN en-wikipedia-org-43 101 8 London London NNP en-wikipedia-org-43 101 9 . . . en-wikipedia-org-43 102 1 Series Series NNP en-wikipedia-org-43 102 2 B B NNP en-wikipedia-org-43 102 3 , , , en-wikipedia-org-43 102 4 Biological Biological NNP en-wikipedia-org-43 102 5 Sciences Sciences NNPS en-wikipedia-org-43 102 6 . . . en-wikipedia-org-43 103 1 361 361 CD en-wikipedia-org-43 103 2 ( ( -LRB- en-wikipedia-org-43 103 3 1473 1473 CD en-wikipedia-org-43 103 4 ) ) -RRB- en-wikipedia-org-43 103 5 : : : en-wikipedia-org-43 103 6 1545–64 1545–64 LS en-wikipedia-org-43 103 7 . . . en-wikipedia-org-43 104 1 doi:10.1098 doi:10.1098 NNP en-wikipedia-org-43 104 2 / / SYM en-wikipedia-org-43 104 3 rstb.2006.1894 rstb.2006.1894 ADD en-wikipedia-org-43 104 4 . . . en-wikipedia-org-43 105 1 PMC PMC NNP en-wikipedia-org-43 105 2   _SP en-wikipedia-org-43 105 3 1664664 1664664 CD en-wikipedia-org-43 105 4 . . . en-wikipedia-org-43 106 1 PMID PMID NNP en-wikipedia-org-43 106 2   _SP en-wikipedia-org-43 106 3 16939974 16939974 CD en-wikipedia-org-43 106 4 . . . en-wikipedia-org-43 107 1 ^ ^ NNP en-wikipedia-org-43 107 2 Allen Allen NNP en-wikipedia-org-43 107 3 SJ SJ NNP en-wikipedia-org-43 107 4 , , , en-wikipedia-org-43 107 5 Dawbarn Dawbarn NNP en-wikipedia-org-43 107 6 D D NNP en-wikipedia-org-43 107 7 ( ( -LRB- en-wikipedia-org-43 107 8 February February NNP en-wikipedia-org-43 107 9 2006 2006 CD en-wikipedia-org-43 107 10 ) ) -RRB- en-wikipedia-org-43 107 11 . . . en-wikipedia-org-43 108 1 " " `` en-wikipedia-org-43 108 2 Clinical clinical JJ en-wikipedia-org-43 108 3 relevance relevance NN en-wikipedia-org-43 108 4 of of IN en-wikipedia-org-43 108 5 the the DT en-wikipedia-org-43 108 6 neurotrophins neurotrophin NNS en-wikipedia-org-43 108 7 and and CC en-wikipedia-org-43 108 8 their -PRON- PRP$ en-wikipedia-org-43 108 9 receptors receptor NNS en-wikipedia-org-43 108 10 " " '' en-wikipedia-org-43 108 11 . . . en-wikipedia-org-43 109 1 Clinical Clinical NNP en-wikipedia-org-43 109 2 Science Science NNP en-wikipedia-org-43 109 3 . . . en-wikipedia-org-43 110 1 110 110 CD en-wikipedia-org-43 110 2 ( ( -LRB- en-wikipedia-org-43 110 3 2 2 CD en-wikipedia-org-43 110 4 ) ) -RRB- en-wikipedia-org-43 110 5 : : : en-wikipedia-org-43 110 6 175–91 175–91 CD en-wikipedia-org-43 110 7 . . . en-wikipedia-org-43 111 1 doi:10.1042 doi:10.1042 NNP en-wikipedia-org-43 111 2 / / SYM en-wikipedia-org-43 111 3 CS20050161 CS20050161 NNP en-wikipedia-org-43 111 4 . . . en-wikipedia-org-43 112 1 PMID PMID NNP en-wikipedia-org-43 112 2   _SP en-wikipedia-org-43 112 3 16411894 16411894 CD en-wikipedia-org-43 112 4 . . . en-wikipedia-org-43 113 1 ^ ^ NNP en-wikipedia-org-43 113 2 Eriksson Eriksson NNP en-wikipedia-org-43 113 3 PS PS NNP en-wikipedia-org-43 113 4 , , , en-wikipedia-org-43 113 5 Perfilieva Perfilieva NNP en-wikipedia-org-43 113 6 E E NNP en-wikipedia-org-43 113 7 , , , en-wikipedia-org-43 113 8 Björk Björk NNP en-wikipedia-org-43 113 9 - - HYPH en-wikipedia-org-43 113 10 Eriksson Eriksson NNP en-wikipedia-org-43 113 11 T T NNP en-wikipedia-org-43 113 12 , , , en-wikipedia-org-43 113 13 Alborn Alborn NNP en-wikipedia-org-43 113 14 AM am NN en-wikipedia-org-43 113 15 , , , en-wikipedia-org-43 113 16 Nordborg Nordborg NNP en-wikipedia-org-43 113 17 C C NNP en-wikipedia-org-43 113 18 , , , en-wikipedia-org-43 113 19 Peterson Peterson NNP en-wikipedia-org-43 113 20 DA DA NNP en-wikipedia-org-43 113 21 , , , en-wikipedia-org-43 113 22 Gage Gage NNP en-wikipedia-org-43 113 23 FH FH NNP en-wikipedia-org-43 113 24 ( ( -LRB- en-wikipedia-org-43 113 25 November November NNP en-wikipedia-org-43 113 26 1998 1998 CD en-wikipedia-org-43 113 27 ) ) -RRB- en-wikipedia-org-43 113 28 . . . en-wikipedia-org-43 114 1 " " `` en-wikipedia-org-43 114 2 Neurogenesis neurogenesis NN en-wikipedia-org-43 114 3 in in IN en-wikipedia-org-43 114 4 the the DT en-wikipedia-org-43 114 5 adult adult NN en-wikipedia-org-43 114 6 human human NN en-wikipedia-org-43 114 7 hippocampus hippocampus NN en-wikipedia-org-43 114 8 " " '' en-wikipedia-org-43 114 9 . . . en-wikipedia-org-43 115 1 Nature Nature NNP en-wikipedia-org-43 115 2 Medicine Medicine NNP en-wikipedia-org-43 115 3 . . . en-wikipedia-org-43 116 1 4 4 CD en-wikipedia-org-43 116 2 ( ( -LRB- en-wikipedia-org-43 116 3 11 11 CD en-wikipedia-org-43 116 4 ) ) -RRB- en-wikipedia-org-43 116 5 : : : en-wikipedia-org-43 116 6 1313–7 1313–7 LS en-wikipedia-org-43 116 7 . . . en-wikipedia-org-43 117 1 doi:10.1038/3305 doi:10.1038/3305 NNP en-wikipedia-org-43 117 2 . . . en-wikipedia-org-43 118 1 PMID PMID NNP en-wikipedia-org-43 118 2   _SP en-wikipedia-org-43 118 3 9809557 9809557 CD en-wikipedia-org-43 118 4 . . . en-wikipedia-org-43 119 1 ^ ^ NN en-wikipedia-org-43 119 2 Neurotrophins neurotrophin NNS en-wikipedia-org-43 119 3 at at IN en-wikipedia-org-43 119 4 the the DT en-wikipedia-org-43 119 5 US US NNP en-wikipedia-org-43 119 6 National National NNP en-wikipedia-org-43 119 7 Library Library NNP en-wikipedia-org-43 119 8 of of IN en-wikipedia-org-43 119 9 Medicine Medicine NNP en-wikipedia-org-43 119 10 Medical Medical NNP en-wikipedia-org-43 119 11 Subject Subject NNP en-wikipedia-org-43 119 12 Headings Headings NNPS en-wikipedia-org-43 119 13 ( ( -LRB- en-wikipedia-org-43 119 14 MeSH MeSH NNP en-wikipedia-org-43 119 15 ) ) -RRB- en-wikipedia-org-43 119 16 ^ ^ FW en-wikipedia-org-43 119 17 a a DT en-wikipedia-org-43 119 18 b b NNP en-wikipedia-org-43 119 19 Malenka Malenka NNP en-wikipedia-org-43 119 20 RC RC NNP en-wikipedia-org-43 119 21 , , , en-wikipedia-org-43 119 22 Nestler Nestler NNP en-wikipedia-org-43 119 23 EJ EJ NNP en-wikipedia-org-43 119 24 , , , en-wikipedia-org-43 119 25 Hyman Hyman NNP en-wikipedia-org-43 119 26 SE SE NNP en-wikipedia-org-43 119 27 ( ( -LRB- en-wikipedia-org-43 119 28 2009 2009 CD en-wikipedia-org-43 119 29 ) ) -RRB- en-wikipedia-org-43 119 30 . . . en-wikipedia-org-43 120 1 " " `` en-wikipedia-org-43 120 2 Chapter chapter NN en-wikipedia-org-43 120 3 8 8 CD en-wikipedia-org-43 120 4 : : : en-wikipedia-org-43 120 5 Atypical atypical JJ en-wikipedia-org-43 120 6 Neurotransmitters Neurotransmitters NNPS en-wikipedia-org-43 120 7 " " '' en-wikipedia-org-43 120 8 . . . en-wikipedia-org-43 121 1 In in IN en-wikipedia-org-43 121 2 Sydor Sydor NNP en-wikipedia-org-43 121 3 A A NNP en-wikipedia-org-43 121 4 , , , en-wikipedia-org-43 121 5 Brown Brown NNP en-wikipedia-org-43 121 6 RY RY NNP en-wikipedia-org-43 121 7 ( ( -LRB- en-wikipedia-org-43 121 8 eds eds NNP en-wikipedia-org-43 121 9 . . . en-wikipedia-org-43 121 10 ) ) -RRB- en-wikipedia-org-43 121 11 . . . en-wikipedia-org-43 122 1 Molecular Molecular NNP en-wikipedia-org-43 122 2 Neuropharmacology Neuropharmacology NNP en-wikipedia-org-43 122 3 : : : en-wikipedia-org-43 122 4 A A NNP en-wikipedia-org-43 122 5 Foundation Foundation NNP en-wikipedia-org-43 122 6 for for IN en-wikipedia-org-43 122 7 Clinical Clinical NNP en-wikipedia-org-43 122 8 Neuroscience Neuroscience NNP en-wikipedia-org-43 122 9 ( ( -LRB- en-wikipedia-org-43 122 10 2nd 2nd NNP en-wikipedia-org-43 122 11 ed ed NNP en-wikipedia-org-43 122 12 . . . en-wikipedia-org-43 122 13 ) ) -RRB- en-wikipedia-org-43 122 14 . . . en-wikipedia-org-43 123 1 New New NNP en-wikipedia-org-43 123 2 York York NNP en-wikipedia-org-43 123 3 : : : en-wikipedia-org-43 123 4 McGraw McGraw NNP en-wikipedia-org-43 123 5 - - HYPH en-wikipedia-org-43 123 6 Hill Hill NNP en-wikipedia-org-43 123 7 Medical Medical NNP en-wikipedia-org-43 123 8 . . . en-wikipedia-org-43 124 1 pp pp NNP en-wikipedia-org-43 124 2 . . . en-wikipedia-org-43 125 1 199 199 CD en-wikipedia-org-43 125 2 , , , en-wikipedia-org-43 125 3 215 215 CD en-wikipedia-org-43 125 4 . . . en-wikipedia-org-43 126 1 ISBN ISBN NNP en-wikipedia-org-43 126 2   _SP en-wikipedia-org-43 126 3 9780071481274 9780071481274 CD en-wikipedia-org-43 126 4 . . . en-wikipedia-org-43 127 1 Neurotrophic neurotrophic JJ en-wikipedia-org-43 127 2 factors factor NNS en-wikipedia-org-43 127 3 are be VBP en-wikipedia-org-43 127 4 polypeptides polypeptide NNS en-wikipedia-org-43 127 5 or or CC en-wikipedia-org-43 127 6 small small JJ en-wikipedia-org-43 127 7 proteins protein NNS en-wikipedia-org-43 127 8 that that WDT en-wikipedia-org-43 127 9 support support VBP en-wikipedia-org-43 127 10 the the DT en-wikipedia-org-43 127 11 growth growth NN en-wikipedia-org-43 127 12 , , , en-wikipedia-org-43 127 13 differentiation differentiation NN en-wikipedia-org-43 127 14 , , , en-wikipedia-org-43 127 15 and and CC en-wikipedia-org-43 127 16 survival survival NN en-wikipedia-org-43 127 17 of of IN en-wikipedia-org-43 127 18 neurons neuron NNS en-wikipedia-org-43 127 19 . . . en-wikipedia-org-43 128 1 They -PRON- PRP en-wikipedia-org-43 128 2 produce produce VBP en-wikipedia-org-43 128 3 their -PRON- PRP$ en-wikipedia-org-43 128 4 effects effect NNS en-wikipedia-org-43 128 5 by by IN en-wikipedia-org-43 128 6 activation activation NN en-wikipedia-org-43 128 7 of of IN en-wikipedia-org-43 128 8 tyrosine tyrosine NN en-wikipedia-org-43 128 9 kinases kinase NNS en-wikipedia-org-43 128 10 . . . en-wikipedia-org-43 129 1 ^ ^ NNP en-wikipedia-org-43 129 2 Sanes Sanes NNP en-wikipedia-org-43 129 3 , , , en-wikipedia-org-43 129 4 Dan Dan NNP en-wikipedia-org-43 129 5 H. H. NNP en-wikipedia-org-43 129 6 , , , en-wikipedia-org-43 129 7 Reh Reh NNP en-wikipedia-org-43 129 8 , , , en-wikipedia-org-43 129 9 Thomas Thomas NNP en-wikipedia-org-43 129 10 A. a. NN en-wikipedia-org-43 129 11 , , , en-wikipedia-org-43 129 12 Harris Harris NNP en-wikipedia-org-43 129 13 , , , en-wikipedia-org-43 129 14 William William NNP en-wikipedia-org-43 129 15 A. A. NNP en-wikipedia-org-43 130 1 Development development NN en-wikipedia-org-43 130 2 of of IN en-wikipedia-org-43 130 3 the the DT en-wikipedia-org-43 130 4 Nervous Nervous NNP en-wikipedia-org-43 130 5 System System NNP en-wikipedia-org-43 130 6 . . . en-wikipedia-org-43 131 1 Academic Academic NNP en-wikipedia-org-43 131 2 Press Press NNP en-wikipedia-org-43 131 3 , , , en-wikipedia-org-43 131 4 2012 2012 CD en-wikipedia-org-43 131 5 , , , en-wikipedia-org-43 131 6 p.173 p.173 NNP en-wikipedia-org-43 131 7 - - HYPH en-wikipedia-org-43 131 8 193 193 CD en-wikipedia-org-43 131 9 . . . en-wikipedia-org-43 132 1 ^ ^ NNP en-wikipedia-org-43 132 2 Sanes Sanes NNP en-wikipedia-org-43 132 3 , , , en-wikipedia-org-43 132 4 Dan Dan NNP en-wikipedia-org-43 132 5 H. H. NNP en-wikipedia-org-43 132 6 ( ( -LRB- en-wikipedia-org-43 132 7 2012 2012 CD en-wikipedia-org-43 132 8 ) ) -RRB- en-wikipedia-org-43 132 9 . . . en-wikipedia-org-43 133 1 Development development NN en-wikipedia-org-43 133 2 of of IN en-wikipedia-org-43 133 3 the the DT en-wikipedia-org-43 133 4 Nervous Nervous NNP en-wikipedia-org-43 133 5 System System NNP en-wikipedia-org-43 133 6 . . . en-wikipedia-org-43 134 1 Academic Academic NNP en-wikipedia-org-43 134 2 Press Press NNP en-wikipedia-org-43 134 3 . . . en-wikipedia-org-43 135 1 pp pp NNP en-wikipedia-org-43 135 2 . . . en-wikipedia-org-43 136 1 173–193 173–193 CD en-wikipedia-org-43 136 2 . . . en-wikipedia-org-43 137 1 ^ ^ NNP en-wikipedia-org-43 137 2 a a DT en-wikipedia-org-43 137 3 b b NN en-wikipedia-org-43 137 4 Hofer Hofer NNP en-wikipedia-org-43 137 5 M M NNP en-wikipedia-org-43 137 6 , , , en-wikipedia-org-43 137 7 Pagliusi Pagliusi NNP en-wikipedia-org-43 137 8 SR SR NNP en-wikipedia-org-43 137 9 , , , en-wikipedia-org-43 137 10 Hohn Hohn NNP en-wikipedia-org-43 137 11 A A NNP en-wikipedia-org-43 137 12 , , , en-wikipedia-org-43 137 13 Leibrock Leibrock NNP en-wikipedia-org-43 137 14 J J NNP en-wikipedia-org-43 137 15 , , , en-wikipedia-org-43 137 16 Barde Barde NNP en-wikipedia-org-43 137 17 YA YA NNP en-wikipedia-org-43 137 18 ( ( -LRB- en-wikipedia-org-43 137 19 August August NNP en-wikipedia-org-43 137 20 1990 1990 CD en-wikipedia-org-43 137 21 ) ) -RRB- en-wikipedia-org-43 137 22 . . . en-wikipedia-org-43 138 1 " " `` en-wikipedia-org-43 138 2 Regional regional JJ en-wikipedia-org-43 138 3 distribution distribution NN en-wikipedia-org-43 138 4 of of IN en-wikipedia-org-43 138 5 brain brain NN en-wikipedia-org-43 138 6 - - HYPH en-wikipedia-org-43 138 7 derived derive VBN en-wikipedia-org-43 138 8 neurotrophic neurotrophic JJ en-wikipedia-org-43 138 9 factor factor NN en-wikipedia-org-43 138 10 mRNA mrna NN en-wikipedia-org-43 138 11 in in IN en-wikipedia-org-43 138 12 the the DT en-wikipedia-org-43 138 13 adult adult NN en-wikipedia-org-43 138 14 mouse mouse NN en-wikipedia-org-43 138 15 brain brain NN en-wikipedia-org-43 138 16 " " '' en-wikipedia-org-43 138 17 . . . en-wikipedia-org-43 139 1 The the DT en-wikipedia-org-43 139 2 EMBO EMBO NNP en-wikipedia-org-43 139 3 Journal Journal NNP en-wikipedia-org-43 139 4 . . . en-wikipedia-org-43 140 1 9 9 CD en-wikipedia-org-43 140 2 ( ( -LRB- en-wikipedia-org-43 140 3 8) 8) CD en-wikipedia-org-43 140 4 : : : en-wikipedia-org-43 140 5 2459–64 2459–64 CD en-wikipedia-org-43 140 6 . . . en-wikipedia-org-43 141 1 doi:10.1002 doi:10.1002 NNP en-wikipedia-org-43 141 2 / / SYM en-wikipedia-org-43 141 3 j.1460 j.1460 NNP en-wikipedia-org-43 141 4 - - HYPH en-wikipedia-org-43 141 5 2075.1990.tb07423.x 2075.1990.tb07423.x CD en-wikipedia-org-43 141 6 . . . en-wikipedia-org-43 142 1 PMC PMC NNP en-wikipedia-org-43 142 2   _SP en-wikipedia-org-43 142 3 552273 552273 CD en-wikipedia-org-43 142 4 . . . en-wikipedia-org-43 143 1 PMID PMID NNP en-wikipedia-org-43 143 2   _SP en-wikipedia-org-43 143 3 2369898 2369898 CD en-wikipedia-org-43 143 4 . . . en-wikipedia-org-43 144 1 ^ ^ NFP en-wikipedia-org-43 144 2 Wistow Wistow NNP en-wikipedia-org-43 144 3 G G NNP en-wikipedia-org-43 144 4 , , , en-wikipedia-org-43 144 5 Piatigorsky Piatigorsky NNP en-wikipedia-org-43 144 6 J J NNP en-wikipedia-org-43 144 7 ( ( -LRB- en-wikipedia-org-43 144 8 June June NNP en-wikipedia-org-43 144 9 1987 1987 CD en-wikipedia-org-43 144 10 ) ) -RRB- en-wikipedia-org-43 144 11 . . . en-wikipedia-org-43 145 1 " " `` en-wikipedia-org-43 145 2 Recruitment recruitment NN en-wikipedia-org-43 145 3 of of IN en-wikipedia-org-43 145 4 enzymes enzyme NNS en-wikipedia-org-43 145 5 as as IN en-wikipedia-org-43 145 6 lens lens NN en-wikipedia-org-43 145 7 structural structural JJ en-wikipedia-org-43 145 8 proteins protein NNS en-wikipedia-org-43 145 9 " " '' en-wikipedia-org-43 145 10 . . . en-wikipedia-org-43 146 1 Science science NN en-wikipedia-org-43 146 2 . . . en-wikipedia-org-43 147 1 236 236 CD en-wikipedia-org-43 147 2 ( ( -LRB- en-wikipedia-org-43 147 3 4808 4808 CD en-wikipedia-org-43 147 4 ) ) -RRB- en-wikipedia-org-43 147 5 : : : en-wikipedia-org-43 147 6 1554–6 1554–6 LS en-wikipedia-org-43 147 7 . . . en-wikipedia-org-43 148 1 Bibcode:1987Sci bibcode:1987sci UH en-wikipedia-org-43 148 2 ... ... NFP en-wikipedia-org-43 148 3 236.1554W. 236.1554w. CD en-wikipedia-org-43 149 1 doi:10.1126 doi:10.1126 NN en-wikipedia-org-43 149 2 / / SYM en-wikipedia-org-43 149 3 science.3589669 science.3589669 NN en-wikipedia-org-43 149 4 . . . en-wikipedia-org-43 150 1 PMID PMID NNP en-wikipedia-org-43 150 2   _SP en-wikipedia-org-43 150 3 3589669 3589669 CD en-wikipedia-org-43 150 4 . . . en-wikipedia-org-43 151 1 ^ ^ NFP en-wikipedia-org-43 151 2 Bradshaw Bradshaw NNP en-wikipedia-org-43 151 3 RA RA NNP en-wikipedia-org-43 151 4 , , , en-wikipedia-org-43 151 5 Blundell Blundell NNP en-wikipedia-org-43 151 6 TL TL NNP en-wikipedia-org-43 151 7 , , , en-wikipedia-org-43 151 8 Lapatto Lapatto NNP en-wikipedia-org-43 151 9 R R NNP en-wikipedia-org-43 151 10 , , , en-wikipedia-org-43 151 11 McDonald McDonald NNP en-wikipedia-org-43 151 12 NQ NQ NNP en-wikipedia-org-43 151 13 , , , en-wikipedia-org-43 151 14 Murray Murray NNP en-wikipedia-org-43 151 15 - - HYPH en-wikipedia-org-43 151 16 Rust Rust NNP en-wikipedia-org-43 151 17 J J NNP en-wikipedia-org-43 151 18 ( ( -LRB- en-wikipedia-org-43 151 19 February February NNP en-wikipedia-org-43 151 20 1993 1993 CD en-wikipedia-org-43 151 21 ) ) -RRB- en-wikipedia-org-43 151 22 . . . en-wikipedia-org-43 152 1 " " `` en-wikipedia-org-43 152 2 Nerve Nerve NNP en-wikipedia-org-43 152 3 growth growth NN en-wikipedia-org-43 152 4 factor factor NN en-wikipedia-org-43 152 5 revisited revisit VBD en-wikipedia-org-43 152 6 " " '' en-wikipedia-org-43 152 7 . . . en-wikipedia-org-43 153 1 Trends trend NNS en-wikipedia-org-43 153 2 in in IN en-wikipedia-org-43 153 3 Biochemical Biochemical NNP en-wikipedia-org-43 153 4 Sciences Sciences NNPS en-wikipedia-org-43 153 5 . . . en-wikipedia-org-43 154 1 18 18 CD en-wikipedia-org-43 154 2 ( ( -LRB- en-wikipedia-org-43 154 3 2 2 CD en-wikipedia-org-43 154 4 ) ) -RRB- en-wikipedia-org-43 154 5 : : : en-wikipedia-org-43 154 6 48–52 48–52 LS en-wikipedia-org-43 154 7 . . . en-wikipedia-org-43 155 1 doi:10.1016/0968 doi:10.1016/0968 NN en-wikipedia-org-43 155 2 - - HYPH en-wikipedia-org-43 155 3 0004(93)90052-O. 0004(93)90052-O. NNP en-wikipedia-org-43 156 1 PMID PMID NNP en-wikipedia-org-43 156 2   _SP en-wikipedia-org-43 156 3 8488558 8488558 CD en-wikipedia-org-43 156 4 . . . en-wikipedia-org-43 157 1 ^ ^ NFP en-wikipedia-org-43 157 2 Koyama Koyama NNP en-wikipedia-org-43 157 3 J J NNP en-wikipedia-org-43 157 4 , , , en-wikipedia-org-43 157 5 Inoue Inoue NNP en-wikipedia-org-43 157 6 S S NNP en-wikipedia-org-43 157 7 , , , en-wikipedia-org-43 157 8 Ikeda Ikeda NNP en-wikipedia-org-43 157 9 K K NNP en-wikipedia-org-43 157 10 , , , en-wikipedia-org-43 157 11 Hayashi Hayashi NNP en-wikipedia-org-43 157 12 K K NNP en-wikipedia-org-43 157 13 ( ( -LRB- en-wikipedia-org-43 157 14 December December NNP en-wikipedia-org-43 157 15 1992 1992 CD en-wikipedia-org-43 157 16 ) ) -RRB- en-wikipedia-org-43 157 17 . . . en-wikipedia-org-43 158 1 " " `` en-wikipedia-org-43 158 2 Purification purification NN en-wikipedia-org-43 158 3 and and CC en-wikipedia-org-43 158 4 amino amino NN en-wikipedia-org-43 158 5 - - HYPH en-wikipedia-org-43 158 6 acid acid NN en-wikipedia-org-43 158 7 sequence sequence NN en-wikipedia-org-43 158 8 of of IN en-wikipedia-org-43 158 9 a a DT en-wikipedia-org-43 158 10 nerve nerve NN en-wikipedia-org-43 158 11 growth growth NN en-wikipedia-org-43 158 12 factor factor NN en-wikipedia-org-43 158 13 from from IN en-wikipedia-org-43 158 14 the the DT en-wikipedia-org-43 158 15 venom venom NN en-wikipedia-org-43 158 16 of of IN en-wikipedia-org-43 158 17 Vipera Vipera NNP en-wikipedia-org-43 158 18 russelli russelli NNP en-wikipedia-org-43 158 19 russelli russelli NN en-wikipedia-org-43 158 20 " " '' en-wikipedia-org-43 158 21 . . . en-wikipedia-org-43 159 1 Biochimica Biochimica NNP en-wikipedia-org-43 159 2 et et NNP en-wikipedia-org-43 159 3 Biophysica Biophysica NNP en-wikipedia-org-43 159 4 Acta Acta NNP en-wikipedia-org-43 159 5 ( ( -LRB- en-wikipedia-org-43 159 6 BBA BBA NNP en-wikipedia-org-43 159 7 ) ) -RRB- en-wikipedia-org-43 159 8 - - : en-wikipedia-org-43 159 9 Protein Protein NNP en-wikipedia-org-43 159 10 Structure Structure NNP en-wikipedia-org-43 159 11 and and CC en-wikipedia-org-43 159 12 Molecular Molecular NNP en-wikipedia-org-43 159 13 Enzymology Enzymology NNP en-wikipedia-org-43 159 14 . . . en-wikipedia-org-43 160 1 1160 1160 CD en-wikipedia-org-43 160 2 ( ( -LRB- en-wikipedia-org-43 160 3 3 3 CD en-wikipedia-org-43 160 4 ) ) -RRB- en-wikipedia-org-43 160 5 : : : en-wikipedia-org-43 160 6 287–92 287–92 CD en-wikipedia-org-43 160 7 . . . en-wikipedia-org-43 161 1 doi:10.1016/0167 doi:10.1016/0167 NNP en-wikipedia-org-43 161 2 - - HYPH en-wikipedia-org-43 161 3 4838(92)90090-Z. 4838(92)90090-Z. NNP en-wikipedia-org-43 162 1 PMID PMID NNP en-wikipedia-org-43 162 2   _SP en-wikipedia-org-43 162 3 1477101 1477101 CD en-wikipedia-org-43 162 4 . . . en-wikipedia-org-43 163 1 ^ ^ NNP en-wikipedia-org-43 163 2 Inoue Inoue NNP en-wikipedia-org-43 163 3 S S NNP en-wikipedia-org-43 163 4 , , , en-wikipedia-org-43 163 5 Oda Oda NNP en-wikipedia-org-43 163 6 T T NNP en-wikipedia-org-43 163 7 , , , en-wikipedia-org-43 163 8 Koyama Koyama NNP en-wikipedia-org-43 163 9 J J NNP en-wikipedia-org-43 163 10 , , , en-wikipedia-org-43 163 11 Ikeda Ikeda NNP en-wikipedia-org-43 163 12 K K NNP en-wikipedia-org-43 163 13 , , , en-wikipedia-org-43 163 14 Hayashi Hayashi NNP en-wikipedia-org-43 163 15 K K NNP en-wikipedia-org-43 163 16 ( ( -LRB- en-wikipedia-org-43 163 17 February February NNP en-wikipedia-org-43 163 18 1991 1991 CD en-wikipedia-org-43 163 19 ) ) -RRB- en-wikipedia-org-43 163 20 . . . en-wikipedia-org-43 164 1 " " `` en-wikipedia-org-43 164 2 Amino amino JJ en-wikipedia-org-43 164 3 acid acid NN en-wikipedia-org-43 164 4 sequences sequence NNS en-wikipedia-org-43 164 5 of of IN en-wikipedia-org-43 164 6 nerve nerve NN en-wikipedia-org-43 164 7 growth growth NN en-wikipedia-org-43 164 8 factors factor NNS en-wikipedia-org-43 164 9 derived derive VBN en-wikipedia-org-43 164 10 from from IN en-wikipedia-org-43 164 11 cobra cobra NN en-wikipedia-org-43 164 12 venoms venom NNS en-wikipedia-org-43 164 13 " " '' en-wikipedia-org-43 164 14 . . . en-wikipedia-org-43 165 1 FEBS FEBS NNP en-wikipedia-org-43 165 2 Letters Letters NNPS en-wikipedia-org-43 165 3 . . . en-wikipedia-org-43 166 1 279 279 CD en-wikipedia-org-43 166 2 ( ( -LRB- en-wikipedia-org-43 166 3 1 1 CD en-wikipedia-org-43 166 4 ) ) -RRB- en-wikipedia-org-43 166 5 : : : en-wikipedia-org-43 166 6 38–40 38–40 CD en-wikipedia-org-43 166 7 . . . en-wikipedia-org-43 167 1 doi:10.1016/0014 doi:10.1016/0014 NNS en-wikipedia-org-43 167 2 - - HYPH en-wikipedia-org-43 167 3 5793(91)80244-W. 5793(91)80244-W. NNP en-wikipedia-org-43 167 4 PMID PMID NNS en-wikipedia-org-43 167 5   _SP en-wikipedia-org-43 167 6 1995338 1995338 CD en-wikipedia-org-43 167 7 . . . en-wikipedia-org-43 168 1 ^ ^ NNP en-wikipedia-org-43 168 2 Arévalo Arévalo NNP en-wikipedia-org-43 168 3 JC JC NNP en-wikipedia-org-43 168 4 , , , en-wikipedia-org-43 168 5 Wu Wu NNP en-wikipedia-org-43 168 6 SH SH NNP en-wikipedia-org-43 168 7 ( ( -LRB- en-wikipedia-org-43 168 8 July July NNP en-wikipedia-org-43 168 9 2006 2006 CD en-wikipedia-org-43 168 10 ) ) -RRB- en-wikipedia-org-43 168 11 . . . en-wikipedia-org-43 169 1 " " `` en-wikipedia-org-43 169 2 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 169 3 signaling signal VBG en-wikipedia-org-43 169 4 : : : en-wikipedia-org-43 169 5 many many JJ en-wikipedia-org-43 169 6 exciting exciting JJ en-wikipedia-org-43 169 7 surprises surprise NNS en-wikipedia-org-43 169 8 ! ! . en-wikipedia-org-43 169 9 " " '' en-wikipedia-org-43 169 10 . . . en-wikipedia-org-43 170 1 Cellular Cellular NNP en-wikipedia-org-43 170 2 and and CC en-wikipedia-org-43 170 3 Molecular Molecular NNP en-wikipedia-org-43 170 4 Life Life NNP en-wikipedia-org-43 170 5 Sciences Sciences NNPS en-wikipedia-org-43 170 6 . . . en-wikipedia-org-43 171 1 63 63 CD en-wikipedia-org-43 171 2 ( ( -LRB- en-wikipedia-org-43 171 3 13 13 CD en-wikipedia-org-43 171 4 ) ) -RRB- en-wikipedia-org-43 171 5 : : : en-wikipedia-org-43 171 6 1523–37 1523–37 LS en-wikipedia-org-43 171 7 . . . en-wikipedia-org-43 172 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-43 172 2 / / SYM en-wikipedia-org-43 172 3 s00018 s00018 NNP en-wikipedia-org-43 172 4 - - HYPH en-wikipedia-org-43 172 5 006 006 CD en-wikipedia-org-43 172 6 - - HYPH en-wikipedia-org-43 172 7 6010 6010 CD en-wikipedia-org-43 172 8 - - HYPH en-wikipedia-org-43 172 9 1 1 CD en-wikipedia-org-43 172 10 . . . en-wikipedia-org-43 173 1 PMID PMID NNP en-wikipedia-org-43 173 2   _SP en-wikipedia-org-43 173 3 16699811 16699811 CD en-wikipedia-org-43 173 4 . . . en-wikipedia-org-43 174 1 ^ ^ NNP en-wikipedia-org-43 174 2 Harrington Harrington NNP en-wikipedia-org-43 174 3 AW AW NNP en-wikipedia-org-43 174 4 , , , en-wikipedia-org-43 174 5 Ginty Ginty NNP en-wikipedia-org-43 174 6 DD DD NNP en-wikipedia-org-43 174 7 ( ( -LRB- en-wikipedia-org-43 174 8 March March NNP en-wikipedia-org-43 174 9 2013 2013 CD en-wikipedia-org-43 174 10 ) ) -RRB- en-wikipedia-org-43 174 11 . . . en-wikipedia-org-43 175 1 " " `` en-wikipedia-org-43 175 2 Long long JJ en-wikipedia-org-43 175 3 - - HYPH en-wikipedia-org-43 175 4 distance distance NN en-wikipedia-org-43 175 5 retrograde retrograde NN en-wikipedia-org-43 175 6 neurotrophic neurotrophic JJ en-wikipedia-org-43 175 7 factor factor NN en-wikipedia-org-43 175 8 signalling signal VBG en-wikipedia-org-43 175 9 in in IN en-wikipedia-org-43 175 10 neurons neuron NNS en-wikipedia-org-43 175 11 " " '' en-wikipedia-org-43 175 12 . . . en-wikipedia-org-43 176 1 Nature Nature NNP en-wikipedia-org-43 176 2 Reviews Reviews NNPS en-wikipedia-org-43 176 3 . . . en-wikipedia-org-43 177 1 Neuroscience Neuroscience NNP en-wikipedia-org-43 177 2 . . . en-wikipedia-org-43 178 1 14 14 CD en-wikipedia-org-43 178 2 ( ( -LRB- en-wikipedia-org-43 178 3 3 3 CD en-wikipedia-org-43 178 4 ) ) -RRB- en-wikipedia-org-43 178 5 : : : en-wikipedia-org-43 178 6 177–87 177–87 CD en-wikipedia-org-43 178 7 . . . en-wikipedia-org-43 179 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-43 179 2 / / SYM en-wikipedia-org-43 179 3 nrn3253 nrn3253 NNP en-wikipedia-org-43 179 4 . . . en-wikipedia-org-43 180 1 PMID PMID NNP en-wikipedia-org-43 180 2   _SP en-wikipedia-org-43 180 3 23422909 23422909 CD en-wikipedia-org-43 180 4 . . . en-wikipedia-org-43 181 1 ^ ^ NFP en-wikipedia-org-43 181 2 Exercise exercise NN en-wikipedia-org-43 181 3 builds build VBZ en-wikipedia-org-43 181 4 brain brain NN en-wikipedia-org-43 181 5 health health NN en-wikipedia-org-43 181 6 : : : en-wikipedia-org-43 181 7 key key JJ en-wikipedia-org-43 181 8 roles role NNS en-wikipedia-org-43 181 9 of of IN en-wikipedia-org-43 181 10 growth growth NN en-wikipedia-org-43 181 11 factor factor NN en-wikipedia-org-43 181 12 cascades cascade VBZ en-wikipedia-org-43 181 13 and and CC en-wikipedia-org-43 181 14 inflammation inflammation NN en-wikipedia-org-43 181 15 by by IN en-wikipedia-org-43 181 16 Carl Carl NNP en-wikipedia-org-43 181 17 W. W. NNP en-wikipedia-org-43 181 18 Cotman Cotman NNP en-wikipedia-org-43 181 19 , , , en-wikipedia-org-43 181 20 Nicole Nicole NNP en-wikipedia-org-43 181 21 C. C. NNP en-wikipedia-org-43 181 22 Berchtold Berchtold NNP en-wikipedia-org-43 181 23 and and CC en-wikipedia-org-43 181 24 Lori Lori NNP en-wikipedia-org-43 181 25 - - HYPH en-wikipedia-org-43 181 26 Ann Ann NNP en-wikipedia-org-43 181 27 Christie Christie NNP en-wikipedia-org-43 181 28 https://scholar.google.com/scholar?cluster=11830727319998892361&hl=en&as_sdt=0,10 https://scholar.google.com/scholar?cluster=11830727319998892361&hl=en&as_sdt=0,10 NNP en-wikipedia-org-43 181 29 ^ ^ NFP en-wikipedia-org-43 181 30 " " `` en-wikipedia-org-43 181 31 Entrez Entrez NNP en-wikipedia-org-43 181 32 database database NN en-wikipedia-org-43 181 33 entry entry NN en-wikipedia-org-43 181 34 for for IN en-wikipedia-org-43 181 35 NT-4/5 NT-4/5 NNP en-wikipedia-org-43 181 36 " " '' en-wikipedia-org-43 181 37 . . . en-wikipedia-org-43 182 1 NCBI NCBI NNP en-wikipedia-org-43 182 2 . . . en-wikipedia-org-43 183 1 Retrieved Retrieved NNP en-wikipedia-org-43 183 2 2007 2007 CD en-wikipedia-org-43 183 3 - - SYM en-wikipedia-org-43 183 4 05 05 CD en-wikipedia-org-43 183 5 - - HYPH en-wikipedia-org-43 183 6 07 07 CD en-wikipedia-org-43 183 7 . . . en-wikipedia-org-43 184 1 ^ ^ NNP en-wikipedia-org-43 184 2 a a DT en-wikipedia-org-43 184 3 b b NN en-wikipedia-org-43 184 4 c c NN en-wikipedia-org-43 184 5 Prough Prough NNP en-wikipedia-org-43 184 6 RA RA NNP en-wikipedia-org-43 184 7 , , , en-wikipedia-org-43 184 8 Clark Clark NNP en-wikipedia-org-43 184 9 BJ BJ NNP en-wikipedia-org-43 184 10 , , , en-wikipedia-org-43 184 11 Klinge Klinge NNP en-wikipedia-org-43 184 12 CM CM NNP en-wikipedia-org-43 184 13 ( ( -LRB- en-wikipedia-org-43 184 14 April April NNP en-wikipedia-org-43 184 15 2016 2016 CD en-wikipedia-org-43 184 16 ) ) -RRB- en-wikipedia-org-43 184 17 . . . en-wikipedia-org-43 185 1 " " `` en-wikipedia-org-43 185 2 Novel novel NN en-wikipedia-org-43 185 3 mechanisms mechanism NNS en-wikipedia-org-43 185 4 for for IN en-wikipedia-org-43 185 5 DHEA dhea NN en-wikipedia-org-43 185 6 action action NN en-wikipedia-org-43 185 7 " " '' en-wikipedia-org-43 185 8 . . . en-wikipedia-org-43 186 1 Journal Journal NNP en-wikipedia-org-43 186 2 of of IN en-wikipedia-org-43 186 3 Molecular Molecular NNP en-wikipedia-org-43 186 4 Endocrinology Endocrinology NNP en-wikipedia-org-43 186 5 . . . en-wikipedia-org-43 187 1 56 56 CD en-wikipedia-org-43 187 2 ( ( -LRB- en-wikipedia-org-43 187 3 3 3 CD en-wikipedia-org-43 187 4 ) ) -RRB- en-wikipedia-org-43 187 5 : : : en-wikipedia-org-43 187 6 R139–55 R139–55 NNP en-wikipedia-org-43 187 7 . . . en-wikipedia-org-43 188 1 doi:10.1530 doi:10.1530 NNP en-wikipedia-org-43 188 2 / / SYM en-wikipedia-org-43 188 3 JME-16 JME-16 NNP en-wikipedia-org-43 188 4 - - HYPH en-wikipedia-org-43 188 5 0013 0013 CD en-wikipedia-org-43 188 6 . . . en-wikipedia-org-43 189 1 PMID PMID NNP en-wikipedia-org-43 189 2   _SP en-wikipedia-org-43 189 3 26908835 26908835 CD en-wikipedia-org-43 189 4 . . . en-wikipedia-org-43 190 1 ^ ^ NN en-wikipedia-org-43 190 2 Lazaridis Lazaridis NNP en-wikipedia-org-43 190 3 I I NNP en-wikipedia-org-43 190 4 , , , en-wikipedia-org-43 190 5 Charalampopoulos Charalampopoulos NNP en-wikipedia-org-43 190 6 I -PRON- PRP en-wikipedia-org-43 190 7 , , , en-wikipedia-org-43 190 8 Alexaki Alexaki NNP en-wikipedia-org-43 190 9 VI VI NNP en-wikipedia-org-43 190 10 , , , en-wikipedia-org-43 190 11 Avlonitis Avlonitis NNP en-wikipedia-org-43 190 12 N N NNP en-wikipedia-org-43 190 13 , , , en-wikipedia-org-43 190 14 Pediaditakis Pediaditakis NNP en-wikipedia-org-43 190 15 I I NNP en-wikipedia-org-43 190 16 , , , en-wikipedia-org-43 190 17 Efstathopoulos Efstathopoulos NNP en-wikipedia-org-43 190 18 P P NNP en-wikipedia-org-43 190 19 , , , en-wikipedia-org-43 190 20 Calogeropoulou Calogeropoulou NNP en-wikipedia-org-43 190 21 T T NNP en-wikipedia-org-43 190 22 , , , en-wikipedia-org-43 190 23 Castanas castanas NN en-wikipedia-org-43 190 24 E e NN en-wikipedia-org-43 190 25 , , , en-wikipedia-org-43 190 26 Gravanis Gravanis NNP en-wikipedia-org-43 190 27 A A NNP en-wikipedia-org-43 190 28 ( ( -LRB- en-wikipedia-org-43 190 29 April April NNP en-wikipedia-org-43 190 30 2011 2011 CD en-wikipedia-org-43 190 31 ) ) -RRB- en-wikipedia-org-43 190 32 . . . en-wikipedia-org-43 191 1 " " `` en-wikipedia-org-43 191 2 Neurosteroid Neurosteroid NNP en-wikipedia-org-43 191 3 dehydroepiandrosterone dehydroepiandrosterone NN en-wikipedia-org-43 191 4 interacts interact VBZ en-wikipedia-org-43 191 5 with with IN en-wikipedia-org-43 191 6 nerve nerve NN en-wikipedia-org-43 191 7 growth growth NN en-wikipedia-org-43 191 8 factor factor NN en-wikipedia-org-43 191 9 ( ( -LRB- en-wikipedia-org-43 191 10 NGF NGF NNP en-wikipedia-org-43 191 11 ) ) -RRB- en-wikipedia-org-43 191 12 receptors receptor NNS en-wikipedia-org-43 191 13 , , , en-wikipedia-org-43 191 14 preventing prevent VBG en-wikipedia-org-43 191 15 neuronal neuronal JJ en-wikipedia-org-43 191 16 apoptosis apoptosis NN en-wikipedia-org-43 191 17 " " '' en-wikipedia-org-43 191 18 . . . en-wikipedia-org-43 192 1 PLOS PLOS NNP en-wikipedia-org-43 192 2 Biology Biology NNP en-wikipedia-org-43 192 3 . . . en-wikipedia-org-43 193 1 9 9 CD en-wikipedia-org-43 193 2 ( ( -LRB- en-wikipedia-org-43 193 3 4 4 CD en-wikipedia-org-43 193 4 ) ) -RRB- en-wikipedia-org-43 193 5 : : : en-wikipedia-org-43 193 6 e1001051 e1001051 CD en-wikipedia-org-43 193 7 . . . en-wikipedia-org-43 194 1 doi:10.1371 doi:10.1371 NNP en-wikipedia-org-43 194 2 / / SYM en-wikipedia-org-43 194 3 journal.pbio.1001051 journal.pbio.1001051 NNP en-wikipedia-org-43 194 4 . . . en-wikipedia-org-43 195 1 PMC PMC NNP en-wikipedia-org-43 195 2   _SP en-wikipedia-org-43 195 3 3082517 3082517 CD en-wikipedia-org-43 195 4 . . . en-wikipedia-org-43 196 1 PMID PMID NNP en-wikipedia-org-43 196 2   _SP en-wikipedia-org-43 196 3 21541365 21541365 CD en-wikipedia-org-43 196 4 . . . en-wikipedia-org-43 197 1 ^ ^ NNP en-wikipedia-org-43 197 2 a a DT en-wikipedia-org-43 197 3 b b NN en-wikipedia-org-43 197 4 Pediaditakis Pediaditakis NNP en-wikipedia-org-43 197 5 I I NNP en-wikipedia-org-43 197 6 , , , en-wikipedia-org-43 197 7 Iliopoulos Iliopoulos NNP en-wikipedia-org-43 197 8 I I NNP en-wikipedia-org-43 197 9 , , , en-wikipedia-org-43 197 10 Theologidis Theologidis NNP en-wikipedia-org-43 197 11 I I NNP en-wikipedia-org-43 197 12 , , , en-wikipedia-org-43 197 13 Delivanoglou Delivanoglou NNP en-wikipedia-org-43 197 14 N N NNP en-wikipedia-org-43 197 15 , , , en-wikipedia-org-43 197 16 Margioris Margioris NNP en-wikipedia-org-43 197 17 AN AN NNP en-wikipedia-org-43 197 18 , , , en-wikipedia-org-43 197 19 Charalampopoulos Charalampopoulos NNP en-wikipedia-org-43 197 20 I -PRON- PRP en-wikipedia-org-43 197 21 , , , en-wikipedia-org-43 197 22 Gravanis Gravanis NNP en-wikipedia-org-43 197 23 A A NNP en-wikipedia-org-43 197 24 ( ( -LRB- en-wikipedia-org-43 197 25 January January NNP en-wikipedia-org-43 197 26 2015 2015 CD en-wikipedia-org-43 197 27 ) ) -RRB- en-wikipedia-org-43 197 28 . . . en-wikipedia-org-43 198 1 " " `` en-wikipedia-org-43 198 2 Dehydroepiandrosterone dehydroepiandrosterone NN en-wikipedia-org-43 198 3 : : : en-wikipedia-org-43 198 4 an an DT en-wikipedia-org-43 198 5 ancestral ancestral JJ en-wikipedia-org-43 198 6 ligand ligand NN en-wikipedia-org-43 198 7 of of IN en-wikipedia-org-43 198 8 neurotrophin neurotrophin NNP en-wikipedia-org-43 198 9 receptors receptor NNS en-wikipedia-org-43 198 10 " " '' en-wikipedia-org-43 198 11 . . . en-wikipedia-org-43 199 1 Endocrinology Endocrinology NNP en-wikipedia-org-43 199 2 . . . en-wikipedia-org-43 200 1 156 156 CD en-wikipedia-org-43 200 2 ( ( -LRB- en-wikipedia-org-43 200 3 1 1 CD en-wikipedia-org-43 200 4 ) ) -RRB- en-wikipedia-org-43 200 5 : : : en-wikipedia-org-43 200 6 16–23 16–23 CD en-wikipedia-org-43 200 7 . . . en-wikipedia-org-43 201 1 doi:10.1210 doi:10.1210 NNP en-wikipedia-org-43 201 2 / / SYM en-wikipedia-org-43 201 3 en.2014 en.2014 NNP en-wikipedia-org-43 201 4 - - SYM en-wikipedia-org-43 201 5 1596 1596 CD en-wikipedia-org-43 201 6 . . . en-wikipedia-org-43 202 1 PMID PMID NNP en-wikipedia-org-43 202 2   _SP en-wikipedia-org-43 202 3 25330101 25330101 CD en-wikipedia-org-43 202 4 . . . en-wikipedia-org-43 203 1 ^ ^ NNP en-wikipedia-org-43 203 2 Gravanis Gravanis NNP en-wikipedia-org-43 203 3 A A NNP en-wikipedia-org-43 203 4 , , , en-wikipedia-org-43 203 5 Calogeropoulou Calogeropoulou NNP en-wikipedia-org-43 203 6 T T NNP en-wikipedia-org-43 203 7 , , , en-wikipedia-org-43 203 8 Panoutsakopoulou Panoutsakopoulou NNP en-wikipedia-org-43 203 9 V V NNP en-wikipedia-org-43 203 10 , , , en-wikipedia-org-43 203 11 Thermos Thermos NNP en-wikipedia-org-43 203 12 K K NNP en-wikipedia-org-43 203 13 , , , en-wikipedia-org-43 203 14 Neophytou Neophytou NNP en-wikipedia-org-43 203 15 C C NNP en-wikipedia-org-43 203 16 , , , en-wikipedia-org-43 203 17 Charalampopoulos Charalampopoulos NNP en-wikipedia-org-43 203 18 I -PRON- PRP en-wikipedia-org-43 203 19 ( ( -LRB- en-wikipedia-org-43 203 20 October October NNP en-wikipedia-org-43 203 21 2012 2012 CD en-wikipedia-org-43 203 22 ) ) -RRB- en-wikipedia-org-43 203 23 . . . en-wikipedia-org-43 204 1 " " `` en-wikipedia-org-43 204 2 Neurosteroids Neurosteroids NNP en-wikipedia-org-43 204 3 and and CC en-wikipedia-org-43 204 4 microneurotrophins microneurotrophin NNS en-wikipedia-org-43 204 5 signal signal NN en-wikipedia-org-43 204 6 through through IN en-wikipedia-org-43 204 7 NGF NGF NNP en-wikipedia-org-43 204 8 receptors receptor NNS en-wikipedia-org-43 204 9 to to TO en-wikipedia-org-43 204 10 induce induce VB en-wikipedia-org-43 204 11 prosurvival prosurvival NN en-wikipedia-org-43 204 12 signaling signal VBG en-wikipedia-org-43 204 13 in in IN en-wikipedia-org-43 204 14 neuronal neuronal JJ en-wikipedia-org-43 204 15 cells cell NNS en-wikipedia-org-43 204 16 " " '' en-wikipedia-org-43 204 17 . . . en-wikipedia-org-43 205 1 Science Science NNP en-wikipedia-org-43 205 2 Signaling Signaling NNP en-wikipedia-org-43 205 3 . . . en-wikipedia-org-43 206 1 5 5 CD en-wikipedia-org-43 206 2 ( ( -LRB- en-wikipedia-org-43 206 3 246 246 CD en-wikipedia-org-43 206 4 ) ) -RRB- en-wikipedia-org-43 206 5 : : : en-wikipedia-org-43 206 6 pt8 pt8 NNP en-wikipedia-org-43 206 7 . . . en-wikipedia-org-43 207 1 doi:10.1126 doi:10.1126 NN en-wikipedia-org-43 207 2 / / SYM en-wikipedia-org-43 207 3 scisignal.2003387 scisignal.2003387 CD en-wikipedia-org-43 207 4 . . . en-wikipedia-org-43 208 1 PMID PMID NNP en-wikipedia-org-43 208 2   _SP en-wikipedia-org-43 208 3 23074265 23074265 CD en-wikipedia-org-43 208 4 . . . en-wikipedia-org-43 209 1 ^ ^ NNP en-wikipedia-org-43 209 2 a a DT en-wikipedia-org-43 209 3 b b NNP en-wikipedia-org-43 209 4 c c NNP en-wikipedia-org-43 209 5 d d NNP en-wikipedia-org-43 209 6 e e NNP en-wikipedia-org-43 209 7 f f NNP en-wikipedia-org-43 209 8 g g NNP en-wikipedia-org-43 209 9 h h NNP en-wikipedia-org-43 209 10 i i NN en-wikipedia-org-43 209 11 Sanes Sanes NNP en-wikipedia-org-43 209 12 , , , en-wikipedia-org-43 209 13 Dan Dan NNP en-wikipedia-org-43 209 14 H. H. NNP en-wikipedia-org-43 209 15 ; ; : en-wikipedia-org-43 209 16 Reh Reh NNP en-wikipedia-org-43 209 17 , , , en-wikipedia-org-43 209 18 Thomas Thomas NNP en-wikipedia-org-43 209 19 A. a. NN en-wikipedia-org-43 209 20 ; ; : en-wikipedia-org-43 209 21 Harris Harris NNP en-wikipedia-org-43 209 22 , , , en-wikipedia-org-43 209 23 William William NNP en-wikipedia-org-43 209 24 A. A. NNP en-wikipedia-org-43 210 1 ( ( -LRB- en-wikipedia-org-43 210 2 2012 2012 CD en-wikipedia-org-43 210 3 ) ) -RRB- en-wikipedia-org-43 210 4 . . . en-wikipedia-org-43 211 1 Development development NN en-wikipedia-org-43 211 2 of of IN en-wikipedia-org-43 211 3 the the DT en-wikipedia-org-43 211 4 Nervous Nervous NNP en-wikipedia-org-43 211 5 System System NNP en-wikipedia-org-43 211 6 . . . en-wikipedia-org-43 212 1 Academic Academic NNP en-wikipedia-org-43 212 2 Press Press NNP en-wikipedia-org-43 212 3 . . . en-wikipedia-org-43 213 1 pp pp NNP en-wikipedia-org-43 213 2 . . . en-wikipedia-org-43 214 1 173–193 173–193 CD en-wikipedia-org-43 214 2 . . . en-wikipedia-org-43 215 1 ^ ^ NNP en-wikipedia-org-43 215 2 a a DT en-wikipedia-org-43 215 3 b b NNP en-wikipedia-org-43 215 4 c c NNP en-wikipedia-org-43 215 5 d d NNP en-wikipedia-org-43 215 6 e e NNP en-wikipedia-org-43 215 7 f f NNP en-wikipedia-org-43 215 8 g g NNP en-wikipedia-org-43 215 9 h h NNP en-wikipedia-org-43 215 10 i i NN en-wikipedia-org-43 215 11 j j NNP en-wikipedia-org-43 215 12 k k NNP en-wikipedia-org-43 215 13 l l NNP en-wikipedia-org-43 215 14 m m NNP en-wikipedia-org-43 215 15 n n CC en-wikipedia-org-43 215 16 o o NNP en-wikipedia-org-43 215 17 p p NN en-wikipedia-org-43 215 18 q q NNP en-wikipedia-org-43 215 19 r r NNP en-wikipedia-org-43 215 20 s s NNP en-wikipedia-org-43 215 21 t t NNP en-wikipedia-org-43 215 22 u u NNP en-wikipedia-org-43 215 23 v v NNP en-wikipedia-org-43 215 24 w w NNP en-wikipedia-org-43 215 25 x x NNP en-wikipedia-org-43 215 26 y y NNP en-wikipedia-org-43 215 27 z z NNP en-wikipedia-org-43 215 28 aa aa NNP en-wikipedia-org-43 215 29 Squire Squire NNP en-wikipedia-org-43 215 30 , , , en-wikipedia-org-43 215 31 Larry Larry NNP en-wikipedia-org-43 215 32 R. R. NNP en-wikipedia-org-43 215 33 ; ; : en-wikipedia-org-43 215 34 Berg Berg NNP en-wikipedia-org-43 215 35 , , , en-wikipedia-org-43 215 36 Darwin Darwin NNP en-wikipedia-org-43 215 37 ; ; : en-wikipedia-org-43 215 38 Bloom Bloom NNP en-wikipedia-org-43 215 39 , , , en-wikipedia-org-43 215 40 Floyd Floyd NNP en-wikipedia-org-43 215 41 E. E. NNP en-wikipedia-org-43 215 42 ; ; : en-wikipedia-org-43 215 43 du du NNP en-wikipedia-org-43 215 44 Lac Lac NNP en-wikipedia-org-43 215 45 , , , en-wikipedia-org-43 215 46 Sascha Sascha NNP en-wikipedia-org-43 215 47 ; ; : en-wikipedia-org-43 215 48 Ghosh Ghosh NNP en-wikipedia-org-43 215 49 , , , en-wikipedia-org-43 215 50 Anirvan Anirvan NNP en-wikipedia-org-43 215 51 ; ; : en-wikipedia-org-43 215 52 Spitzer Spitzer NNP en-wikipedia-org-43 215 53 , , , en-wikipedia-org-43 215 54 Nicholas Nicholas NNP en-wikipedia-org-43 215 55 C. C. NNP en-wikipedia-org-43 215 56 ( ( -LRB- en-wikipedia-org-43 215 57 2013 2013 CD en-wikipedia-org-43 215 58 ) ) -RRB- en-wikipedia-org-43 215 59 . . . en-wikipedia-org-43 216 1 Fundamental fundamental JJ en-wikipedia-org-43 216 2 Neuroscience Neuroscience NNP en-wikipedia-org-43 216 3 . . . en-wikipedia-org-43 217 1 Academic Academic NNP en-wikipedia-org-43 217 2 Press Press NNP en-wikipedia-org-43 217 3 . . . en-wikipedia-org-43 218 1 pp pp NNP en-wikipedia-org-43 218 2 . . . en-wikipedia-org-43 219 1 405–435 405–435 CD en-wikipedia-org-43 219 2 . . . en-wikipedia-org-43 220 1 ISBN ISBN NNP en-wikipedia-org-43 220 2   _SP en-wikipedia-org-43 220 3 978 978 CD en-wikipedia-org-43 220 4 - - HYPH en-wikipedia-org-43 220 5 0 0 CD en-wikipedia-org-43 220 6 - - HYPH en-wikipedia-org-43 220 7 12 12 CD en-wikipedia-org-43 220 8 - - HYPH en-wikipedia-org-43 220 9 385870 385870 CD en-wikipedia-org-43 220 10 - - HYPH en-wikipedia-org-43 220 11 2 2 CD en-wikipedia-org-43 220 12 . . . en-wikipedia-org-43 221 1 ^ ^ NNP en-wikipedia-org-43 221 2 Bamji Bamji NNP en-wikipedia-org-43 221 3 SX SX NNP en-wikipedia-org-43 221 4 , , , en-wikipedia-org-43 221 5 Majdan Majdan NNP en-wikipedia-org-43 221 6 M M NNP en-wikipedia-org-43 221 7 , , , en-wikipedia-org-43 221 8 Pozniak Pozniak NNP en-wikipedia-org-43 221 9 CD CD NNP en-wikipedia-org-43 221 10 , , , en-wikipedia-org-43 221 11 Belliveau Belliveau NNP en-wikipedia-org-43 221 12 DJ DJ NNP en-wikipedia-org-43 221 13 , , , en-wikipedia-org-43 221 14 Aloyz Aloyz NNP en-wikipedia-org-43 221 15 R R NNP en-wikipedia-org-43 221 16 , , , en-wikipedia-org-43 221 17 Kohn Kohn NNP en-wikipedia-org-43 221 18 J J NNP en-wikipedia-org-43 221 19 , , , en-wikipedia-org-43 221 20 Causing cause VBG en-wikipedia-org-43 221 21 CG CG NNP en-wikipedia-org-43 221 22 , , , en-wikipedia-org-43 221 23 Miller Miller NNP en-wikipedia-org-43 221 24 FD FD NNP en-wikipedia-org-43 221 25 ( ( -LRB- en-wikipedia-org-43 221 26 February February NNP en-wikipedia-org-43 221 27 1998 1998 CD en-wikipedia-org-43 221 28 ) ) -RRB- en-wikipedia-org-43 221 29 . . . en-wikipedia-org-43 222 1 " " `` en-wikipedia-org-43 222 2 The the DT en-wikipedia-org-43 222 3 p75 p75 NN en-wikipedia-org-43 222 4 neurotrophin neurotrophin NNP en-wikipedia-org-43 222 5 receptor receptor NN en-wikipedia-org-43 222 6 mediates mediate VBZ en-wikipedia-org-43 222 7 neuronal neuronal JJ en-wikipedia-org-43 222 8 apoptosis apoptosis NN en-wikipedia-org-43 222 9 and and CC en-wikipedia-org-43 222 10 is be VBZ en-wikipedia-org-43 222 11 essential essential JJ en-wikipedia-org-43 222 12 for for IN en-wikipedia-org-43 222 13 naturally naturally RB en-wikipedia-org-43 222 14 occurring occur VBG en-wikipedia-org-43 222 15 sympathetic sympathetic JJ en-wikipedia-org-43 222 16 neuron neuron NN en-wikipedia-org-43 222 17 death death NN en-wikipedia-org-43 222 18 " " '' en-wikipedia-org-43 222 19 . . . en-wikipedia-org-43 223 1 The the DT en-wikipedia-org-43 223 2 Journal Journal NNP en-wikipedia-org-43 223 3 of of IN en-wikipedia-org-43 223 4 Cell Cell NNP en-wikipedia-org-43 223 5 Biology Biology NNP en-wikipedia-org-43 223 6 . . . en-wikipedia-org-43 224 1 140 140 CD en-wikipedia-org-43 224 2 ( ( -LRB- en-wikipedia-org-43 224 3 4 4 CD en-wikipedia-org-43 224 4 ) ) -RRB- en-wikipedia-org-43 224 5 : : : en-wikipedia-org-43 224 6 911–23 911–23 CD en-wikipedia-org-43 224 7 . . . en-wikipedia-org-43 225 1 doi:10.1083 doi:10.1083 NNP en-wikipedia-org-43 225 2 / / SYM en-wikipedia-org-43 225 3 jcb.140.4.911 jcb.140.4.911 NNPS en-wikipedia-org-43 225 4 . . . en-wikipedia-org-43 226 1 PMC PMC NNP en-wikipedia-org-43 226 2   _SP en-wikipedia-org-43 226 3 2141754 2141754 CD en-wikipedia-org-43 226 4 . . . en-wikipedia-org-43 227 1 PMID PMID NNP en-wikipedia-org-43 227 2   _SP en-wikipedia-org-43 227 3 9472042 9472042 CD en-wikipedia-org-43 227 4 . . . en-wikipedia-org-43 228 1 ^ ^ NNP en-wikipedia-org-43 228 2 a a DT en-wikipedia-org-43 228 3 b b NNP en-wikipedia-org-43 228 4 c c NNP en-wikipedia-org-43 228 5 d d NNP en-wikipedia-org-43 228 6 e e NNP en-wikipedia-org-43 228 7 f f NNP en-wikipedia-org-43 228 8 g g NNP en-wikipedia-org-43 228 9 Lu Lu NNP en-wikipedia-org-43 228 10 B B NNP en-wikipedia-org-43 228 11 , , , en-wikipedia-org-43 228 12 Pang Pang NNP en-wikipedia-org-43 228 13 PT PT NNP en-wikipedia-org-43 228 14 , , , en-wikipedia-org-43 228 15 Woo Woo NNP en-wikipedia-org-43 228 16 NH NH NNP en-wikipedia-org-43 228 17 ( ( -LRB- en-wikipedia-org-43 228 18 August August NNP en-wikipedia-org-43 228 19 2005 2005 CD en-wikipedia-org-43 228 20 ) ) -RRB- en-wikipedia-org-43 228 21 . . . en-wikipedia-org-43 229 1 " " `` en-wikipedia-org-43 229 2 The the DT en-wikipedia-org-43 229 3 yin yin NN en-wikipedia-org-43 229 4 and and CC en-wikipedia-org-43 229 5 yang yang NNP en-wikipedia-org-43 229 6 of of IN en-wikipedia-org-43 229 7 neurotrophin neurotrophin NNP en-wikipedia-org-43 229 8 action action NNP en-wikipedia-org-43 229 9 " " '' en-wikipedia-org-43 229 10 . . . en-wikipedia-org-43 230 1 Nature Nature NNP en-wikipedia-org-43 230 2 Reviews Reviews NNPS en-wikipedia-org-43 230 3 . . . en-wikipedia-org-43 231 1 Neuroscience Neuroscience NNP en-wikipedia-org-43 231 2 . . . en-wikipedia-org-43 232 1 6 6 CD en-wikipedia-org-43 232 2 ( ( -LRB- en-wikipedia-org-43 232 3 8) 8) CD en-wikipedia-org-43 232 4 : : : en-wikipedia-org-43 232 5 603–14 603–14 CD en-wikipedia-org-43 232 6 . . . en-wikipedia-org-43 233 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-43 233 2 / / SYM en-wikipedia-org-43 233 3 nrn1726 nrn1726 NNP en-wikipedia-org-43 233 4 . . . en-wikipedia-org-43 234 1 PMID PMID NNP en-wikipedia-org-43 234 2   _SP en-wikipedia-org-43 234 3 16062169 16062169 CD en-wikipedia-org-43 234 4 . . . en-wikipedia-org-43 235 1 ^ ^ NNP en-wikipedia-org-43 235 2 Nikoletopoulou Nikoletopoulou NNP en-wikipedia-org-43 235 3 V V NNP en-wikipedia-org-43 235 4 , , , en-wikipedia-org-43 235 5 Lickert Lickert NNP en-wikipedia-org-43 235 6 H H NNP en-wikipedia-org-43 235 7 , , , en-wikipedia-org-43 235 8 Frade Frade NNP en-wikipedia-org-43 235 9 JM JM NNP en-wikipedia-org-43 235 10 , , , en-wikipedia-org-43 235 11 Rencurel Rencurel NNP en-wikipedia-org-43 235 12 C C NNP en-wikipedia-org-43 235 13 , , , en-wikipedia-org-43 235 14 Giallonardo Giallonardo NNP en-wikipedia-org-43 235 15 P P NNP en-wikipedia-org-43 235 16 , , , en-wikipedia-org-43 235 17 Zhang Zhang NNP en-wikipedia-org-43 235 18 L L NNP en-wikipedia-org-43 235 19 , , , en-wikipedia-org-43 235 20 Bibel Bibel NNP en-wikipedia-org-43 235 21 M M NNP en-wikipedia-org-43 235 22 , , , en-wikipedia-org-43 235 23 Barde Barde NNP en-wikipedia-org-43 235 24 YA YA NNP en-wikipedia-org-43 235 25 ( ( -LRB- en-wikipedia-org-43 235 26 September September NNP en-wikipedia-org-43 235 27 2010 2010 CD en-wikipedia-org-43 235 28 ) ) -RRB- en-wikipedia-org-43 235 29 . . . en-wikipedia-org-43 236 1 " " `` en-wikipedia-org-43 236 2 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 236 3 receptors receptor NNS en-wikipedia-org-43 236 4 TrkA TrkA NNP en-wikipedia-org-43 236 5 and and CC en-wikipedia-org-43 236 6 TrkC TrkC NNP en-wikipedia-org-43 236 7 cause cause IN en-wikipedia-org-43 236 8 neuronal neuronal JJ en-wikipedia-org-43 236 9 death death NN en-wikipedia-org-43 236 10 whereas whereas IN en-wikipedia-org-43 236 11 TrkB TrkB NNP en-wikipedia-org-43 236 12 does do VBZ en-wikipedia-org-43 236 13 not not RB en-wikipedia-org-43 236 14 " " '' en-wikipedia-org-43 236 15 ( ( -LRB- en-wikipedia-org-43 236 16 PDF PDF NNP en-wikipedia-org-43 236 17 ) ) -RRB- en-wikipedia-org-43 236 18 . . . en-wikipedia-org-43 237 1 Nature nature NN en-wikipedia-org-43 237 2 . . . en-wikipedia-org-43 238 1 467 467 CD en-wikipedia-org-43 238 2 ( ( -LRB- en-wikipedia-org-43 238 3 7311 7311 CD en-wikipedia-org-43 238 4 ) ) -RRB- en-wikipedia-org-43 238 5 : : : en-wikipedia-org-43 238 6 59–63 59–63 CD en-wikipedia-org-43 238 7 . . . en-wikipedia-org-43 239 1 Bibcode:2010Natur.467 bibcode:2010natur.467 LS en-wikipedia-org-43 239 2 ... ... . en-wikipedia-org-43 239 3 59N. 59n. ADD en-wikipedia-org-43 240 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-43 240 2 / / SYM en-wikipedia-org-43 240 3 nature09336 nature09336 NNP en-wikipedia-org-43 240 4 . . . en-wikipedia-org-43 241 1 hdl:10261/27437 hdl:10261/27437 NNP en-wikipedia-org-43 241 2 . . . en-wikipedia-org-43 242 1 PMID PMID NNP en-wikipedia-org-43 242 2   _SP en-wikipedia-org-43 242 3 20811452 20811452 CD en-wikipedia-org-43 242 4 . . . en-wikipedia-org-43 243 1 ^ ^ NNP en-wikipedia-org-43 243 2 a a DT en-wikipedia-org-43 243 3 b b NN en-wikipedia-org-43 243 4 c c NN en-wikipedia-org-43 243 5 Teng Teng NNP en-wikipedia-org-43 243 6 KK KK NNP en-wikipedia-org-43 243 7 , , , en-wikipedia-org-43 243 8 Felice Felice NNP en-wikipedia-org-43 243 9 S S NNP en-wikipedia-org-43 243 10 , , , en-wikipedia-org-43 243 11 Kim Kim NNP en-wikipedia-org-43 243 12 T T NNP en-wikipedia-org-43 243 13 , , , en-wikipedia-org-43 243 14 Hempstead Hempstead NNP en-wikipedia-org-43 243 15 BL BL NNP en-wikipedia-org-43 243 16 ( ( -LRB- en-wikipedia-org-43 243 17 April April NNP en-wikipedia-org-43 243 18 2010 2010 CD en-wikipedia-org-43 243 19 ) ) -RRB- en-wikipedia-org-43 243 20 . . . en-wikipedia-org-43 244 1 " " `` en-wikipedia-org-43 244 2 Understanding understand VBG en-wikipedia-org-43 244 3 proneurotrophin proneurotrophin JJ en-wikipedia-org-43 244 4 actions action NNS en-wikipedia-org-43 244 5 : : : en-wikipedia-org-43 244 6 Recent recent JJ en-wikipedia-org-43 244 7 advances advance NNS en-wikipedia-org-43 244 8 and and CC en-wikipedia-org-43 244 9 challenges challenge NNS en-wikipedia-org-43 244 10 " " '' en-wikipedia-org-43 244 11 . . . en-wikipedia-org-43 245 1 Developmental Developmental NNP en-wikipedia-org-43 245 2 Neurobiology Neurobiology NNP en-wikipedia-org-43 245 3 . . . en-wikipedia-org-43 246 1 70 70 CD en-wikipedia-org-43 246 2 ( ( -LRB- en-wikipedia-org-43 246 3 5 5 CD en-wikipedia-org-43 246 4 ) ) -RRB- en-wikipedia-org-43 246 5 : : : en-wikipedia-org-43 246 6 350–9 350–9 CD en-wikipedia-org-43 246 7 . . . en-wikipedia-org-43 247 1 doi:10.1002 doi:10.1002 NNP en-wikipedia-org-43 247 2 / / SYM en-wikipedia-org-43 247 3 dneu.20768 dneu.20768 NNP en-wikipedia-org-43 247 4 . . . en-wikipedia-org-43 248 1 PMC PMC NNP en-wikipedia-org-43 248 2   _SP en-wikipedia-org-43 248 3 3063094 3063094 CD en-wikipedia-org-43 248 4 . . . en-wikipedia-org-43 249 1 PMID PMID NNP en-wikipedia-org-43 249 2   _SP en-wikipedia-org-43 249 3 20186707 20186707 CD en-wikipedia-org-43 249 4 . . . en-wikipedia-org-43 250 1 ^ ^ NNP en-wikipedia-org-43 250 2 a a DT en-wikipedia-org-43 250 3 b b NN en-wikipedia-org-43 250 4 c c NN en-wikipedia-org-43 250 5 Dhanasekaran Dhanasekaran NNP en-wikipedia-org-43 250 6 DN DN NNP en-wikipedia-org-43 250 7 , , , en-wikipedia-org-43 250 8 Reddy Reddy NNP en-wikipedia-org-43 250 9 EP EP NNP en-wikipedia-org-43 250 10 ( ( -LRB- en-wikipedia-org-43 250 11 October October NNP en-wikipedia-org-43 250 12 2008 2008 CD en-wikipedia-org-43 250 13 ) ) -RRB- en-wikipedia-org-43 250 14 . . . en-wikipedia-org-43 251 1 " " `` en-wikipedia-org-43 251 2 JNK JNK NNP en-wikipedia-org-43 251 3 signaling signal VBG en-wikipedia-org-43 251 4 in in IN en-wikipedia-org-43 251 5 apoptosis apoptosis NN en-wikipedia-org-43 251 6 " " '' en-wikipedia-org-43 251 7 . . . en-wikipedia-org-43 252 1 Oncogene oncogene NN en-wikipedia-org-43 252 2 . . . en-wikipedia-org-43 253 1 27 27 CD en-wikipedia-org-43 253 2 ( ( -LRB- en-wikipedia-org-43 253 3 48 48 CD en-wikipedia-org-43 253 4 ) ) -RRB- en-wikipedia-org-43 253 5 : : : en-wikipedia-org-43 253 6 6245–51 6245–51 LS en-wikipedia-org-43 253 7 . . . en-wikipedia-org-43 254 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-43 254 2 / / SYM en-wikipedia-org-43 254 3 onc.2008.301 onc.2008.301 NNP en-wikipedia-org-43 254 4 . . . en-wikipedia-org-43 255 1 PMC PMC NNP en-wikipedia-org-43 255 2   _SP en-wikipedia-org-43 255 3 3063296 3063296 CD en-wikipedia-org-43 255 4 . . . en-wikipedia-org-43 256 1 PMID PMID NNP en-wikipedia-org-43 256 2   _SP en-wikipedia-org-43 256 3 18931691 18931691 CD en-wikipedia-org-43 256 4 . . . en-wikipedia-org-43 257 1 ^ ^ NNP en-wikipedia-org-43 257 2 a a DT en-wikipedia-org-43 257 3 b b NNP en-wikipedia-org-43 257 4 c c NNP en-wikipedia-org-43 257 5 d d NNP en-wikipedia-org-43 257 6 e e NNP en-wikipedia-org-43 257 7 f f NNP en-wikipedia-org-43 257 8 g g NNP en-wikipedia-org-43 257 9 h h NNP en-wikipedia-org-43 257 10 i i NN en-wikipedia-org-43 257 11 j j NNP en-wikipedia-org-43 257 12 Huang Huang NNP en-wikipedia-org-43 257 13 EJ EJ NNP en-wikipedia-org-43 257 14 , , , en-wikipedia-org-43 257 15 Reichardt Reichardt NNP en-wikipedia-org-43 257 16 LF LF NNP en-wikipedia-org-43 257 17 ( ( -LRB- en-wikipedia-org-43 257 18 2001 2001 CD en-wikipedia-org-43 257 19 ) ) -RRB- en-wikipedia-org-43 257 20 . . . en-wikipedia-org-43 258 1 " " `` en-wikipedia-org-43 258 2 Neurotrophins neurotrophin NNS en-wikipedia-org-43 258 3 : : : en-wikipedia-org-43 258 4 roles role NNS en-wikipedia-org-43 258 5 in in IN en-wikipedia-org-43 258 6 neuronal neuronal JJ en-wikipedia-org-43 258 7 development development NN en-wikipedia-org-43 258 8 and and CC en-wikipedia-org-43 258 9 function function NN en-wikipedia-org-43 258 10 " " '' en-wikipedia-org-43 258 11 . . . en-wikipedia-org-43 259 1 Annual Annual NNP en-wikipedia-org-43 259 2 Review Review NNP en-wikipedia-org-43 259 3 of of IN en-wikipedia-org-43 259 4 Neuroscience Neuroscience NNP en-wikipedia-org-43 259 5 . . . en-wikipedia-org-43 260 1 24 24 CD en-wikipedia-org-43 260 2 : : : en-wikipedia-org-43 260 3 677–736 677–736 CD en-wikipedia-org-43 260 4 . . . en-wikipedia-org-43 261 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-43 261 2 / / SYM en-wikipedia-org-43 261 3 annurev.neuro.24.1.677 annurev.neuro.24.1.677 NN en-wikipedia-org-43 261 4 . . . en-wikipedia-org-43 262 1 PMC PMC NNP en-wikipedia-org-43 262 2   _SP en-wikipedia-org-43 262 3 2758233 2758233 CD en-wikipedia-org-43 262 4 . . . en-wikipedia-org-43 263 1 PMID PMID NNP en-wikipedia-org-43 263 2   _SP en-wikipedia-org-43 263 3 11520916 11520916 CD en-wikipedia-org-43 263 4 . . . en-wikipedia-org-43 264 1 ^ ^ NNP en-wikipedia-org-43 264 2 Longo Longo NNP en-wikipedia-org-43 264 3 FM FM NNP en-wikipedia-org-43 264 4 , , , en-wikipedia-org-43 264 5 Massa Massa NNP en-wikipedia-org-43 264 6 SM SM NNP en-wikipedia-org-43 264 7 ( ( -LRB- en-wikipedia-org-43 264 8 July July NNP en-wikipedia-org-43 264 9 2013 2013 CD en-wikipedia-org-43 264 10 ) ) -RRB- en-wikipedia-org-43 264 11 . . . en-wikipedia-org-43 265 1 " " `` en-wikipedia-org-43 265 2 Small small JJ en-wikipedia-org-43 265 3 - - HYPH en-wikipedia-org-43 265 4 molecule molecule NN en-wikipedia-org-43 265 5 modulation modulation NN en-wikipedia-org-43 265 6 of of IN en-wikipedia-org-43 265 7 neurotrophin neurotrophin JJ en-wikipedia-org-43 265 8 receptors receptor NNS en-wikipedia-org-43 265 9 : : : en-wikipedia-org-43 265 10 a a DT en-wikipedia-org-43 265 11 strategy strategy NN en-wikipedia-org-43 265 12 for for IN en-wikipedia-org-43 265 13 the the DT en-wikipedia-org-43 265 14 treatment treatment NN en-wikipedia-org-43 265 15 of of IN en-wikipedia-org-43 265 16 neurological neurological JJ en-wikipedia-org-43 265 17 disease disease NN en-wikipedia-org-43 265 18 " " '' en-wikipedia-org-43 265 19 . . . en-wikipedia-org-43 266 1 Nature Nature NNP en-wikipedia-org-43 266 2 Reviews Reviews NNPS en-wikipedia-org-43 266 3 . . . en-wikipedia-org-43 267 1 Drug Drug NNP en-wikipedia-org-43 267 2 Discovery Discovery NNP en-wikipedia-org-43 267 3 . . . en-wikipedia-org-43 268 1 12 12 CD en-wikipedia-org-43 268 2 ( ( -LRB- en-wikipedia-org-43 268 3 7 7 CD en-wikipedia-org-43 268 4 ) ) -RRB- en-wikipedia-org-43 268 5 : : : en-wikipedia-org-43 268 6 507–25 507–25 CD en-wikipedia-org-43 268 7 . . . en-wikipedia-org-43 269 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-43 269 2 / / SYM en-wikipedia-org-43 269 3 nrd4024 nrd4024 NNP en-wikipedia-org-43 269 4 . . . en-wikipedia-org-43 270 1 PMID PMID NNP en-wikipedia-org-43 270 2   _SP en-wikipedia-org-43 270 3 23977697 23977697 CD en-wikipedia-org-43 270 4 . . . en-wikipedia-org-43 271 1 ^ ^ NNP en-wikipedia-org-43 271 2 Yoon Yoon NNP en-wikipedia-org-43 271 3 SO SO NNP en-wikipedia-org-43 271 4 , , , en-wikipedia-org-43 271 5 Casaccia Casaccia NNP en-wikipedia-org-43 271 6 - - HYPH en-wikipedia-org-43 271 7 Bonnefil Bonnefil NNP en-wikipedia-org-43 271 8 P P NNP en-wikipedia-org-43 271 9 , , , en-wikipedia-org-43 271 10 Carter Carter NNP en-wikipedia-org-43 271 11 B B NNP en-wikipedia-org-43 271 12 , , , en-wikipedia-org-43 271 13 Chao Chao NNP en-wikipedia-org-43 271 14 MV MV NNP en-wikipedia-org-43 271 15 ( ( -LRB- en-wikipedia-org-43 271 16 May May NNP en-wikipedia-org-43 271 17 1998 1998 CD en-wikipedia-org-43 271 18 ) ) -RRB- en-wikipedia-org-43 271 19 . . . en-wikipedia-org-43 272 1 " " `` en-wikipedia-org-43 272 2 Competitive competitive JJ en-wikipedia-org-43 272 3 signaling signaling NN en-wikipedia-org-43 272 4 between between IN en-wikipedia-org-43 272 5 TrkA TrkA NNP en-wikipedia-org-43 272 6 and and CC en-wikipedia-org-43 272 7 p75 p75 NN en-wikipedia-org-43 272 8 nerve nerve NN en-wikipedia-org-43 272 9 growth growth NN en-wikipedia-org-43 272 10 factor factor NN en-wikipedia-org-43 272 11 receptors receptor NNS en-wikipedia-org-43 272 12 determines determine VBZ en-wikipedia-org-43 272 13 cell cell NN en-wikipedia-org-43 272 14 survival survival NN en-wikipedia-org-43 272 15 " " '' en-wikipedia-org-43 272 16 . . . en-wikipedia-org-43 273 1 The the DT en-wikipedia-org-43 273 2 Journal Journal NNP en-wikipedia-org-43 273 3 of of IN en-wikipedia-org-43 273 4 Neuroscience Neuroscience NNP en-wikipedia-org-43 273 5 . . . en-wikipedia-org-43 274 1 18 18 CD en-wikipedia-org-43 274 2 ( ( -LRB- en-wikipedia-org-43 274 3 9 9 CD en-wikipedia-org-43 274 4 ) ) -RRB- en-wikipedia-org-43 274 5 : : : en-wikipedia-org-43 274 6 3273–81 3273–81 LS en-wikipedia-org-43 274 7 . . . en-wikipedia-org-43 275 1 doi:10.1523 doi:10.1523 NNP en-wikipedia-org-43 275 2 / / SYM en-wikipedia-org-43 275 3 JNEUROSCI.18 jneurosci.18 $ en-wikipedia-org-43 275 4 - - HYPH en-wikipedia-org-43 275 5 09 09 CD en-wikipedia-org-43 275 6 - - HYPH en-wikipedia-org-43 275 7 03273.1998 03273.1998 CD en-wikipedia-org-43 275 8 . . . en-wikipedia-org-43 276 1 PMC PMC NNP en-wikipedia-org-43 276 2   _SP en-wikipedia-org-43 276 3 6792655 6792655 CD en-wikipedia-org-43 276 4 . . . en-wikipedia-org-43 277 1 PMID PMID NNP en-wikipedia-org-43 277 2   _SP en-wikipedia-org-43 277 3 9547236 9547236 CD en-wikipedia-org-43 277 4 . . . en-wikipedia-org-43 278 1 ^ ^ NNP en-wikipedia-org-43 278 2 a a DT en-wikipedia-org-43 278 3 b b NNP en-wikipedia-org-43 278 4 c c NNP en-wikipedia-org-43 278 5 Dekkers Dekkers NNP en-wikipedia-org-43 278 6 MP MP NNP en-wikipedia-org-43 278 7 , , , en-wikipedia-org-43 278 8 Nikoletopoulou Nikoletopoulou NNP en-wikipedia-org-43 278 9 V V NNP en-wikipedia-org-43 278 10 , , , en-wikipedia-org-43 278 11 Barde Barde NNP en-wikipedia-org-43 278 12 YA YA NNP en-wikipedia-org-43 278 13 ( ( -LRB- en-wikipedia-org-43 278 14 November November NNP en-wikipedia-org-43 278 15 2013 2013 CD en-wikipedia-org-43 278 16 ) ) -RRB- en-wikipedia-org-43 278 17 . . . en-wikipedia-org-43 279 1 " " `` en-wikipedia-org-43 279 2 Cell cell NN en-wikipedia-org-43 279 3 biology biology NN en-wikipedia-org-43 279 4 in in IN en-wikipedia-org-43 279 5 neuroscience neuroscience NN en-wikipedia-org-43 279 6 : : : en-wikipedia-org-43 279 7 Death death NN en-wikipedia-org-43 279 8 of of IN en-wikipedia-org-43 279 9 developing develop VBG en-wikipedia-org-43 279 10 neurons neuron NNS en-wikipedia-org-43 279 11 : : : en-wikipedia-org-43 279 12 new new JJ en-wikipedia-org-43 279 13 insights insight NNS en-wikipedia-org-43 279 14 and and CC en-wikipedia-org-43 279 15 implications implication NNS en-wikipedia-org-43 279 16 for for IN en-wikipedia-org-43 279 17 connectivity connectivity NN en-wikipedia-org-43 279 18 " " '' en-wikipedia-org-43 279 19 . . . en-wikipedia-org-43 280 1 The the DT en-wikipedia-org-43 280 2 Journal Journal NNP en-wikipedia-org-43 280 3 of of IN en-wikipedia-org-43 280 4 Cell Cell NNP en-wikipedia-org-43 280 5 Biology Biology NNP en-wikipedia-org-43 280 6 . . . en-wikipedia-org-43 281 1 203 203 CD en-wikipedia-org-43 281 2 ( ( -LRB- en-wikipedia-org-43 281 3 3 3 CD en-wikipedia-org-43 281 4 ) ) -RRB- en-wikipedia-org-43 281 5 : : : en-wikipedia-org-43 281 6 385–93 385–93 CD en-wikipedia-org-43 281 7 . . . en-wikipedia-org-43 282 1 doi:10.1083 doi:10.1083 NNP en-wikipedia-org-43 282 2 / / SYM en-wikipedia-org-43 282 3 jcb.201306136 jcb.201306136 NN en-wikipedia-org-43 282 4 . . . en-wikipedia-org-43 283 1 PMC PMC NNP en-wikipedia-org-43 283 2   _SP en-wikipedia-org-43 283 3 3824005 3824005 CD en-wikipedia-org-43 283 4 . . . en-wikipedia-org-43 284 1 PMID PMID NNP en-wikipedia-org-43 284 2   _SP en-wikipedia-org-43 284 3 24217616 24217616 CD en-wikipedia-org-43 284 4 . . . en-wikipedia-org-43 285 1 ^ ^ NNP en-wikipedia-org-43 285 2 a a DT en-wikipedia-org-43 285 3 b b NN en-wikipedia-org-43 285 4 c c NN en-wikipedia-org-43 285 5 d d NN en-wikipedia-org-43 285 6 Lessmann Lessmann NNP en-wikipedia-org-43 285 7 V V NNP en-wikipedia-org-43 285 8 , , , en-wikipedia-org-43 285 9 Gottmann Gottmann NNP en-wikipedia-org-43 285 10 K K NNP en-wikipedia-org-43 285 11 , , , en-wikipedia-org-43 285 12 Malcangio Malcangio NNP en-wikipedia-org-43 285 13 M M NNP en-wikipedia-org-43 285 14 ( ( -LRB- en-wikipedia-org-43 285 15 April April NNP en-wikipedia-org-43 285 16 2003 2003 CD en-wikipedia-org-43 285 17 ) ) -RRB- en-wikipedia-org-43 285 18 . . . en-wikipedia-org-43 286 1 " " `` en-wikipedia-org-43 286 2 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 286 3 secretion secretion NN en-wikipedia-org-43 286 4 : : : en-wikipedia-org-43 286 5 current current JJ en-wikipedia-org-43 286 6 facts fact NNS en-wikipedia-org-43 286 7 and and CC en-wikipedia-org-43 286 8 future future JJ en-wikipedia-org-43 286 9 prospects prospect NNS en-wikipedia-org-43 286 10 " " '' en-wikipedia-org-43 286 11 . . . en-wikipedia-org-43 287 1 Progress progress NN en-wikipedia-org-43 287 2 in in IN en-wikipedia-org-43 287 3 Neurobiology Neurobiology NNP en-wikipedia-org-43 287 4 . . . en-wikipedia-org-43 288 1 69 69 CD en-wikipedia-org-43 288 2 ( ( -LRB- en-wikipedia-org-43 288 3 5 5 CD en-wikipedia-org-43 288 4 ) ) -RRB- en-wikipedia-org-43 288 5 : : : en-wikipedia-org-43 288 6 341–74 341–74 CD en-wikipedia-org-43 288 7 . . . en-wikipedia-org-43 289 1 doi:10.1016 doi:10.1016 LS en-wikipedia-org-43 289 2 / / SYM en-wikipedia-org-43 289 3 s0301 s0301 NN en-wikipedia-org-43 289 4 - - HYPH en-wikipedia-org-43 289 5 0082(03)00019 0082(03)00019 NN en-wikipedia-org-43 289 6 - - HYPH en-wikipedia-org-43 289 7 4 4 CD en-wikipedia-org-43 289 8 . . . en-wikipedia-org-43 290 1 PMID PMID NNP en-wikipedia-org-43 290 2   _SP en-wikipedia-org-43 290 3 12787574 12787574 CD en-wikipedia-org-43 290 4 . . . en-wikipedia-org-43 291 1 ^ ^ NFP en-wikipedia-org-43 291 2 Ernsberger Ernsberger NNP en-wikipedia-org-43 291 3 U u PRP en-wikipedia-org-43 291 4 ( ( -LRB- en-wikipedia-org-43 291 5 June June NNP en-wikipedia-org-43 291 6 2009 2009 CD en-wikipedia-org-43 291 7 ) ) -RRB- en-wikipedia-org-43 291 8 . . . en-wikipedia-org-43 292 1 " " `` en-wikipedia-org-43 292 2 Role role NN en-wikipedia-org-43 292 3 of of IN en-wikipedia-org-43 292 4 neurotrophin neurotrophin JJ en-wikipedia-org-43 292 5 signalling signal VBG en-wikipedia-org-43 292 6 in in IN en-wikipedia-org-43 292 7 the the DT en-wikipedia-org-43 292 8 differentiation differentiation NN en-wikipedia-org-43 292 9 of of IN en-wikipedia-org-43 292 10 neurons neuron NNS en-wikipedia-org-43 292 11 from from IN en-wikipedia-org-43 292 12 dorsal dorsal NN en-wikipedia-org-43 292 13 root root NN en-wikipedia-org-43 292 14 ganglia ganglia NNP en-wikipedia-org-43 292 15 and and CC en-wikipedia-org-43 292 16 sympathetic sympathetic JJ en-wikipedia-org-43 292 17 ganglia ganglia NN en-wikipedia-org-43 292 18 " " '' en-wikipedia-org-43 292 19 . . . en-wikipedia-org-43 293 1 Cell Cell NNP en-wikipedia-org-43 293 2 and and CC en-wikipedia-org-43 293 3 Tissue Tissue NNP en-wikipedia-org-43 293 4 Research Research NNP en-wikipedia-org-43 293 5 . . . en-wikipedia-org-43 294 1 336 336 CD en-wikipedia-org-43 294 2 ( ( -LRB- en-wikipedia-org-43 294 3 3 3 CD en-wikipedia-org-43 294 4 ) ) -RRB- en-wikipedia-org-43 294 5 : : : en-wikipedia-org-43 294 6 349–84 349–84 CD en-wikipedia-org-43 294 7 . . . en-wikipedia-org-43 295 1 doi:10.1007 doi:10.1007 VB en-wikipedia-org-43 295 2 / / SYM en-wikipedia-org-43 295 3 S00441 S00441 NNP en-wikipedia-org-43 295 4 - - HYPH en-wikipedia-org-43 295 5 009 009 CD en-wikipedia-org-43 295 6 - - HYPH en-wikipedia-org-43 295 7 0784-Z. 0784-z. CD en-wikipedia-org-43 296 1 PMID PMID NNP en-wikipedia-org-43 296 2   _SP en-wikipedia-org-43 296 3 19387688 19387688 CD en-wikipedia-org-43 296 4 . . . en-wikipedia-org-43 297 1 External External NNP en-wikipedia-org-43 297 2 links[edit links[edit , en-wikipedia-org-43 297 3 ] ] -RRB- en-wikipedia-org-43 297 4 DevBio.com devbio.com ADD en-wikipedia-org-43 297 5 - - HYPH en-wikipedia-org-43 297 6 ' ' '' en-wikipedia-org-43 297 7 Neurotrophin Neurotrophin NNP en-wikipedia-org-43 297 8 Receptors Receptors NNPS en-wikipedia-org-43 297 9 : : : en-wikipedia-org-43 297 10 The the DT en-wikipedia-org-43 297 11 neurotrophin neurotrophin JJ en-wikipedia-org-43 297 12 family family NN en-wikipedia-org-43 297 13 consists consist VBZ en-wikipedia-org-43 297 14 of of IN en-wikipedia-org-43 297 15 four four CD en-wikipedia-org-43 297 16 members member NNS en-wikipedia-org-43 297 17 : : : en-wikipedia-org-43 297 18 nerve nerve NN en-wikipedia-org-43 297 19 growth growth NN en-wikipedia-org-43 297 20 factor factor NN en-wikipedia-org-43 297 21 ( ( -LRB- en-wikipedia-org-43 297 22 NGF NGF NNP en-wikipedia-org-43 297 23 ) ) -RRB- en-wikipedia-org-43 297 24 , , , en-wikipedia-org-43 297 25 brain brain NN en-wikipedia-org-43 297 26 derived derive VBN en-wikipedia-org-43 297 27 neurotrophic neurotrophic JJ en-wikipedia-org-43 297 28 factor factor NN en-wikipedia-org-43 297 29 ( ( -LRB- en-wikipedia-org-43 297 30 BDNF BDNF NNP en-wikipedia-org-43 297 31 ) ) -RRB- en-wikipedia-org-43 297 32 , , , en-wikipedia-org-43 297 33 neurotrophin neurotrophin NNP en-wikipedia-org-43 297 34 3 3 CD en-wikipedia-org-43 297 35 ( ( -LRB- en-wikipedia-org-43 297 36 NT-3 NT-3 NNP en-wikipedia-org-43 297 37 ) ) -RRB- en-wikipedia-org-43 297 38 , , , en-wikipedia-org-43 297 39 and and CC en-wikipedia-org-43 297 40 neurotrophin neurotrophin NNP en-wikipedia-org-43 297 41 4 4 CD en-wikipedia-org-43 297 42 ( ( -LRB- en-wikipedia-org-43 297 43 NT-4 NT-4 NNP en-wikipedia-org-43 297 44 ) ) -RRB- en-wikipedia-org-43 297 45 ' ' '' en-wikipedia-org-43 297 46 ( ( -LRB- en-wikipedia-org-43 297 47 April April NNP en-wikipedia-org-43 297 48 4 4 CD en-wikipedia-org-43 297 49 , , , en-wikipedia-org-43 297 50 2003 2003 CD en-wikipedia-org-43 297 51 ) ) -RRB- en-wikipedia-org-43 297 52 Dr.Koop.com dr.koop.com NN en-wikipedia-org-43 297 53 - - : en-wikipedia-org-43 297 54 ' ' '' en-wikipedia-org-43 297 55 New New NNP en-wikipedia-org-43 297 56 Clues Clues NNPS en-wikipedia-org-43 297 57 to to IN en-wikipedia-org-43 297 58 Neurological Neurological NNP en-wikipedia-org-43 297 59 Diseases Diseases NNPS en-wikipedia-org-43 297 60 Discovered discover VBN en-wikipedia-org-43 297 61 : : : en-wikipedia-org-43 297 62 Findings finding NNS en-wikipedia-org-43 297 63 could could MD en-wikipedia-org-43 297 64 lead lead VB en-wikipedia-org-43 297 65 to to IN en-wikipedia-org-43 297 66 new new JJ en-wikipedia-org-43 297 67 treatments treatment NNS en-wikipedia-org-43 297 68 , , , en-wikipedia-org-43 297 69 two two CD en-wikipedia-org-43 297 70 studies study NNS en-wikipedia-org-43 297 71 suggest suggest VBP en-wikipedia-org-43 297 72 ' ' '' en-wikipedia-org-43 297 73 , , , en-wikipedia-org-43 297 74 Steven Steven NNP en-wikipedia-org-43 297 75 Reinberg Reinberg NNP en-wikipedia-org-43 297 76 , , , en-wikipedia-org-43 297 77 HealthDay HealthDay NNP en-wikipedia-org-43 297 78 ( ( -LRB- en-wikipedia-org-43 297 79 July July NNP en-wikipedia-org-43 297 80 5 5 CD en-wikipedia-org-43 297 81 , , , en-wikipedia-org-43 297 82 2006 2006 CD en-wikipedia-org-43 297 83 ) ) -RRB- en-wikipedia-org-43 297 84 Helsinki.fi helsinki.fi VB en-wikipedia-org-43 297 85 - - HYPH en-wikipedia-org-43 297 86 ' ' '' en-wikipedia-org-43 297 87 Neurotrophic neurotrophic JJ en-wikipedia-org-43 297 88 factors factor NNS en-wikipedia-org-43 297 89 ' ' POS en-wikipedia-org-43 297 90 Neurotrophins neurotrophin NNS en-wikipedia-org-43 297 91 at at IN en-wikipedia-org-43 297 92 the the DT en-wikipedia-org-43 297 93 US US NNP en-wikipedia-org-43 297 94 National National NNP en-wikipedia-org-43 297 95 Library Library NNP en-wikipedia-org-43 297 96 of of IN en-wikipedia-org-43 297 97 Medicine Medicine NNP en-wikipedia-org-43 297 98 Medical Medical NNP en-wikipedia-org-43 297 99 Subject Subject NNP en-wikipedia-org-43 297 100 Headings Headings NNPS en-wikipedia-org-43 297 101 ( ( -LRB- en-wikipedia-org-43 297 102 MeSH MeSH NNP en-wikipedia-org-43 297 103 ) ) -RRB- en-wikipedia-org-43 297 104 [ [ -LRB- en-wikipedia-org-43 297 105 1 1 CD en-wikipedia-org-43 297 106 ] ] -RRB- en-wikipedia-org-43 297 107 - - : en-wikipedia-org-43 297 108 Neurotrophin-3 Neurotrophin-3 NNP en-wikipedia-org-43 297 109 image image NN en-wikipedia-org-43 297 110 v v NN en-wikipedia-org-43 297 111 t t NN en-wikipedia-org-43 297 112 e e NNP en-wikipedia-org-43 297 113 Cell cell NN en-wikipedia-org-43 297 114 signaling signal VBG en-wikipedia-org-43 297 115 : : : en-wikipedia-org-43 297 116 Nervous nervous JJ en-wikipedia-org-43 297 117 tissue tissue NN en-wikipedia-org-43 297 118 : : : en-wikipedia-org-43 297 119 Neurotrophic neurotrophic JJ en-wikipedia-org-43 297 120 factors factor NNS en-wikipedia-org-43 297 121 Neurotrophins Neurotrophins NNP en-wikipedia-org-43 297 122 NGF NGF NNP en-wikipedia-org-43 297 123 BDNF BDNF NNP en-wikipedia-org-43 297 124 NT-3 NT-3 NNP en-wikipedia-org-43 297 125 NT-4 NT-4 NNP en-wikipedia-org-43 297 126 GDNF GDNF NNP en-wikipedia-org-43 297 127 family family NN en-wikipedia-org-43 297 128 GDNF GDNF NNP en-wikipedia-org-43 297 129 Artemin Artemin NNP en-wikipedia-org-43 297 130 Neurturin Neurturin NNP en-wikipedia-org-43 297 131 Persephin Persephin NNP en-wikipedia-org-43 297 132 Ephrins Ephrins NNP en-wikipedia-org-43 297 133 A1 A1 NNP en-wikipedia-org-43 297 134 A2 A2 NNP en-wikipedia-org-43 297 135 A3 A3 NNP en-wikipedia-org-43 297 136 A4 A4 NNP en-wikipedia-org-43 297 137 A5 A5 NNP en-wikipedia-org-43 297 138 B1 B1 NNP en-wikipedia-org-43 297 139 B2 B2 NNP en-wikipedia-org-43 297 140 B3 B3 NNP en-wikipedia-org-43 297 141 CNTF CNTF NNP en-wikipedia-org-43 297 142 family family NN en-wikipedia-org-43 297 143 CNTF CNTF NNP en-wikipedia-org-43 297 144 LIF LIF NNP en-wikipedia-org-43 297 145 IL-6 IL-6 NNP en-wikipedia-org-43 297 146 Other Other NNP en-wikipedia-org-43 297 147 GMF GMF NNP en-wikipedia-org-43 297 148 IGF-1 IGF-1 NNP en-wikipedia-org-43 297 149 Neuregulins Neuregulins NNP en-wikipedia-org-43 297 150 1 1 CD en-wikipedia-org-43 297 151 2 2 CD en-wikipedia-org-43 297 152 3 3 CD en-wikipedia-org-43 297 153 4 4 CD en-wikipedia-org-43 297 154 PACAP PACAP NNP en-wikipedia-org-43 297 155 VEGF vegf NN en-wikipedia-org-43 297 156 v v NN en-wikipedia-org-43 297 157 t t NN en-wikipedia-org-43 297 158 e e NNP en-wikipedia-org-43 297 159 Growth growth NN en-wikipedia-org-43 297 160 factor factor NN en-wikipedia-org-43 297 161 receptor receptor NN en-wikipedia-org-43 297 162 modulators modulator NNS en-wikipedia-org-43 297 163 Angiopoietin Angiopoietin NNP en-wikipedia-org-43 297 164 Agonists Agonists NNPS en-wikipedia-org-43 297 165 : : : en-wikipedia-org-43 297 166 Angiopoietin Angiopoietin NNP en-wikipedia-org-43 297 167 1 1 CD en-wikipedia-org-43 297 168 Angiopoietin Angiopoietin NNP en-wikipedia-org-43 297 169 4 4 CD en-wikipedia-org-43 297 170 Antagonists Antagonists NNPS en-wikipedia-org-43 297 171 : : : en-wikipedia-org-43 297 172 Angiopoietin Angiopoietin NNP en-wikipedia-org-43 297 173 2 2 CD en-wikipedia-org-43 297 174 Angiopoietin Angiopoietin NNP en-wikipedia-org-43 297 175 3 3 CD en-wikipedia-org-43 297 176 Kinase Kinase NNP en-wikipedia-org-43 297 177 inhibitors inhibitor NNS en-wikipedia-org-43 297 178 : : : en-wikipedia-org-43 297 179 Altiratinib Altiratinib NNP en-wikipedia-org-43 297 180 CE-245677 CE-245677 NNP en-wikipedia-org-43 297 181 Rebastinib Rebastinib NNP en-wikipedia-org-43 297 182 Antibodies Antibodies NNPS en-wikipedia-org-43 297 183 : : : en-wikipedia-org-43 297 184 Evinacumab Evinacumab NNP en-wikipedia-org-43 297 185 ( ( -LRB- en-wikipedia-org-43 297 186 against against IN en-wikipedia-org-43 297 187 angiopoietin angiopoietin NNP en-wikipedia-org-43 297 188 3 3 CD en-wikipedia-org-43 297 189 ) ) -RRB- en-wikipedia-org-43 297 190 Nesvacumab Nesvacumab NNP en-wikipedia-org-43 297 191 ( ( -LRB- en-wikipedia-org-43 297 192 against against IN en-wikipedia-org-43 297 193 angiopoietin angiopoietin NNP en-wikipedia-org-43 297 194 2 2 CD en-wikipedia-org-43 297 195 ) ) -RRB- en-wikipedia-org-43 297 196 CNTF CNTF NNP en-wikipedia-org-43 297 197 Agonists agonist NNS en-wikipedia-org-43 297 198 : : : en-wikipedia-org-43 297 199 Axokine axokine VB en-wikipedia-org-43 297 200 CNTF CNTF NNP en-wikipedia-org-43 297 201 Dapiclermin Dapiclermin NNP en-wikipedia-org-43 297 202 EGF EGF NNP en-wikipedia-org-43 297 203 ( ( -LRB- en-wikipedia-org-43 297 204 ErbB ErbB NNP en-wikipedia-org-43 297 205 ) ) -RRB- en-wikipedia-org-43 297 206 EGF EGF NNP en-wikipedia-org-43 297 207 ( ( -LRB- en-wikipedia-org-43 297 208 ErbB1 ErbB1 NNP en-wikipedia-org-43 297 209 / / SYM en-wikipedia-org-43 297 210 HER1 HER1 NNP en-wikipedia-org-43 297 211 ) ) -RRB- en-wikipedia-org-43 297 212 Agonists agonist NNS en-wikipedia-org-43 297 213 : : : en-wikipedia-org-43 297 214 Amphiregulin Amphiregulin NNP en-wikipedia-org-43 297 215 Betacellulin Betacellulin NNP en-wikipedia-org-43 297 216 EGF EGF NNP en-wikipedia-org-43 297 217 ( ( -LRB- en-wikipedia-org-43 297 218 urogastrone urogastrone NN en-wikipedia-org-43 297 219 ) ) -RRB- en-wikipedia-org-43 297 220 Epigen Epigen NNP en-wikipedia-org-43 297 221 Epiregulin Epiregulin NNP en-wikipedia-org-43 297 222 Heparin Heparin NNP en-wikipedia-org-43 297 223 - - HYPH en-wikipedia-org-43 297 224 binding bind VBG en-wikipedia-org-43 297 225 EGF EGF NNP en-wikipedia-org-43 297 226 - - HYPH en-wikipedia-org-43 297 227 like like JJ en-wikipedia-org-43 297 228 growth growth NN en-wikipedia-org-43 297 229 factor factor NN en-wikipedia-org-43 297 230 ( ( -LRB- en-wikipedia-org-43 297 231 HB HB NNP en-wikipedia-org-43 297 232 - - HYPH en-wikipedia-org-43 297 233 EGF EGF NNP en-wikipedia-org-43 297 234 ) ) -RRB- en-wikipedia-org-43 297 235 Murodermin Murodermin NNP en-wikipedia-org-43 297 236 Nepidermin Nepidermin NNP en-wikipedia-org-43 297 237 Transforming Transforming NNP en-wikipedia-org-43 297 238 growth growth NN en-wikipedia-org-43 297 239 factor factor NN en-wikipedia-org-43 297 240 alpha alpha NN en-wikipedia-org-43 297 241 ( ( -LRB- en-wikipedia-org-43 297 242 TGFα TGFα NNP en-wikipedia-org-43 297 243 ) ) -RRB- en-wikipedia-org-43 297 244 Kinase Kinase NNP en-wikipedia-org-43 297 245 inhibitors inhibitor NNS en-wikipedia-org-43 297 246 : : : en-wikipedia-org-43 297 247 Afatinib Afatinib NNP en-wikipedia-org-43 297 248 AG-490 AG-490 NNP en-wikipedia-org-43 297 249 Agerafenib Agerafenib NNP en-wikipedia-org-43 297 250 Brigatinib Brigatinib NNP en-wikipedia-org-43 297 251 Canertinib Canertinib NNP en-wikipedia-org-43 297 252 Dacomitinib Dacomitinib NNP en-wikipedia-org-43 297 253 Erlotinib Erlotinib NNP en-wikipedia-org-43 297 254 Gefitinib Gefitinib NNP en-wikipedia-org-43 297 255 Grandinin Grandinin NNP en-wikipedia-org-43 297 256 Icotinib Icotinib NNP en-wikipedia-org-43 297 257 Lapatinib Lapatinib NNP en-wikipedia-org-43 297 258 Neratinib Neratinib NNP en-wikipedia-org-43 297 259 Osimertinib Osimertinib NNP en-wikipedia-org-43 297 260 Vandetanib Vandetanib NNP en-wikipedia-org-43 297 261 WHI WHI NNP en-wikipedia-org-43 297 262 - - HYPH en-wikipedia-org-43 297 263 P P NNP en-wikipedia-org-43 297 264 154 154 CD en-wikipedia-org-43 297 265 Antibodies antibody NNS en-wikipedia-org-43 297 266 : : : en-wikipedia-org-43 297 267 Cetuximab Cetuximab NNP en-wikipedia-org-43 297 268 Depatuxizumab Depatuxizumab NNS en-wikipedia-org-43 297 269 Depatuxizumab Depatuxizumab NNPS en-wikipedia-org-43 297 270 mafodotin mafodotin VBP en-wikipedia-org-43 297 271 Futuximab Futuximab NNP en-wikipedia-org-43 297 272 Imgatuzumab Imgatuzumab NNP en-wikipedia-org-43 297 273 Matuzumab Matuzumab NNP en-wikipedia-org-43 297 274 Necitumumab Necitumumab NNP en-wikipedia-org-43 297 275 Nimotuzumab Nimotuzumab NNP en-wikipedia-org-43 297 276 Panitumumab Panitumumab NNP en-wikipedia-org-43 297 277 Zalutumumab Zalutumumab NNP en-wikipedia-org-43 297 278 ErbB2 ErbB2 NNP en-wikipedia-org-43 297 279 / / SYM en-wikipedia-org-43 297 280 HER2 HER2 NNP en-wikipedia-org-43 297 281 Agonists Agonists NNPS en-wikipedia-org-43 297 282 : : : en-wikipedia-org-43 297 283 Unknown unknown JJ en-wikipedia-org-43 297 284 / / SYM en-wikipedia-org-43 297 285 none none NN en-wikipedia-org-43 297 286 Antibodies antibody NNS en-wikipedia-org-43 297 287 : : : en-wikipedia-org-43 297 288 Ertumaxomab Ertumaxomab NNP en-wikipedia-org-43 297 289 Pertuzumab Pertuzumab NNP en-wikipedia-org-43 297 290 Trastuzumab Trastuzumab NNP en-wikipedia-org-43 297 291 Trastuzumab Trastuzumab NNP en-wikipedia-org-43 297 292 duocarmazine duocarmazine NN en-wikipedia-org-43 297 293 Trastuzumab Trastuzumab NNP en-wikipedia-org-43 297 294 emtansine emtansine VBP en-wikipedia-org-43 297 295 Kinase Kinase NNP en-wikipedia-org-43 297 296 inhibitors inhibitor NNS en-wikipedia-org-43 297 297 : : : en-wikipedia-org-43 297 298 Afatinib Afatinib NNP en-wikipedia-org-43 297 299 AG-490 AG-490 NNP en-wikipedia-org-43 297 300 Lapatinib Lapatinib NNP en-wikipedia-org-43 297 301 Mubritinib Mubritinib NNP en-wikipedia-org-43 297 302 Neratinib Neratinib NNP en-wikipedia-org-43 297 303 Tucatinib Tucatinib NNP en-wikipedia-org-43 297 304 ErbB3 ErbB3 NNP en-wikipedia-org-43 297 305 / / SYM en-wikipedia-org-43 297 306 HER3 HER3 NNP en-wikipedia-org-43 297 307 Agonists Agonists NNPS en-wikipedia-org-43 297 308 : : : en-wikipedia-org-43 297 309 Neuregulins Neuregulins NNP en-wikipedia-org-43 297 310 ( ( -LRB- en-wikipedia-org-43 297 311 heregulins heregulin NNS en-wikipedia-org-43 297 312 ) ) -RRB- en-wikipedia-org-43 297 313 ( ( -LRB- en-wikipedia-org-43 297 314 1 1 CD en-wikipedia-org-43 297 315 , , , en-wikipedia-org-43 297 316 2 2 CD en-wikipedia-org-43 297 317 , , , en-wikipedia-org-43 297 318 6 6 CD en-wikipedia-org-43 297 319 ( ( -LRB- en-wikipedia-org-43 297 320 neuroglycan neuroglycan NNP en-wikipedia-org-43 297 321 C C NNP en-wikipedia-org-43 297 322 ) ) -RRB- en-wikipedia-org-43 297 323 ) ) -RRB- en-wikipedia-org-43 297 324 Antibodies antibody NNS en-wikipedia-org-43 297 325 : : : en-wikipedia-org-43 297 326 Duligotumab Duligotumab NNP en-wikipedia-org-43 297 327 Patritumab Patritumab NNP en-wikipedia-org-43 297 328 Seribantumab Seribantumab NNP en-wikipedia-org-43 297 329 ErbB4 ErbB4 NNP en-wikipedia-org-43 297 330 / / SYM en-wikipedia-org-43 297 331 HER4 HER4 NNP en-wikipedia-org-43 297 332 Agonists Agonists NNPS en-wikipedia-org-43 297 333 : : : en-wikipedia-org-43 297 334 Betacellulin Betacellulin NNP en-wikipedia-org-43 297 335 Epigen Epigen NNP en-wikipedia-org-43 297 336 Heparin Heparin NNP en-wikipedia-org-43 297 337 - - HYPH en-wikipedia-org-43 297 338 binding bind VBG en-wikipedia-org-43 297 339 EGF EGF NNP en-wikipedia-org-43 297 340 - - HYPH en-wikipedia-org-43 297 341 like like JJ en-wikipedia-org-43 297 342 growth growth NN en-wikipedia-org-43 297 343 factor factor NN en-wikipedia-org-43 297 344 ( ( -LRB- en-wikipedia-org-43 297 345 HB HB NNP en-wikipedia-org-43 297 346 - - HYPH en-wikipedia-org-43 297 347 EGF EGF NNP en-wikipedia-org-43 297 348 ) ) -RRB- en-wikipedia-org-43 297 349 Neuregulins Neuregulins NNP en-wikipedia-org-43 297 350 ( ( -LRB- en-wikipedia-org-43 297 351 heregulins heregulin NNS en-wikipedia-org-43 297 352 ) ) -RRB- en-wikipedia-org-43 297 353 ( ( -LRB- en-wikipedia-org-43 297 354 1 1 CD en-wikipedia-org-43 297 355 , , , en-wikipedia-org-43 297 356 2 2 CD en-wikipedia-org-43 297 357 , , , en-wikipedia-org-43 297 358 3 3 CD en-wikipedia-org-43 297 359 , , , en-wikipedia-org-43 297 360 4 4 CD en-wikipedia-org-43 297 361 , , , en-wikipedia-org-43 297 362 5 5 CD en-wikipedia-org-43 297 363 ( ( -LRB- en-wikipedia-org-43 297 364 tomoregulin tomoregulin NN en-wikipedia-org-43 297 365 , , , en-wikipedia-org-43 297 366 TMEFF TMEFF NNP en-wikipedia-org-43 297 367 ) ) -RRB- en-wikipedia-org-43 297 368 ) ) -RRB- en-wikipedia-org-43 297 369 FGF FGF NNP en-wikipedia-org-43 297 370 FGFR1 fgfr1 CD en-wikipedia-org-43 297 371 Agonists agonist NNS en-wikipedia-org-43 297 372 : : : en-wikipedia-org-43 297 373 Ersofermin Ersofermin NNP en-wikipedia-org-43 297 374 FGF FGF NNP en-wikipedia-org-43 297 375 ( ( -LRB- en-wikipedia-org-43 297 376 1 1 CD en-wikipedia-org-43 297 377 , , , en-wikipedia-org-43 297 378 2 2 CD en-wikipedia-org-43 297 379 ( ( -LRB- en-wikipedia-org-43 297 380 bFGF bfgf NN en-wikipedia-org-43 297 381 ) ) -RRB- en-wikipedia-org-43 297 382 , , , en-wikipedia-org-43 297 383 3 3 CD en-wikipedia-org-43 297 384 , , , en-wikipedia-org-43 297 385 4 4 CD en-wikipedia-org-43 297 386 , , , en-wikipedia-org-43 297 387 5 5 CD en-wikipedia-org-43 297 388 , , , en-wikipedia-org-43 297 389 6 6 CD en-wikipedia-org-43 297 390 , , , en-wikipedia-org-43 297 391 8 8 CD en-wikipedia-org-43 297 392 , , , en-wikipedia-org-43 297 393 10 10 CD en-wikipedia-org-43 297 394 ( ( -LRB- en-wikipedia-org-43 297 395 KGF2 KGF2 NNP en-wikipedia-org-43 297 396 ) ) -RRB- en-wikipedia-org-43 297 397 , , , en-wikipedia-org-43 297 398 20 20 CD en-wikipedia-org-43 297 399 ) ) -RRB- en-wikipedia-org-43 297 400 Repifermin Repifermin NNP en-wikipedia-org-43 297 401 Selpercatinib Selpercatinib NNP en-wikipedia-org-43 297 402 Trafermin Trafermin NNP en-wikipedia-org-43 297 403 Velafermin Velafermin NNP en-wikipedia-org-43 297 404 FGFR2 fgfr2 NN en-wikipedia-org-43 297 405 Agonists agonist NNS en-wikipedia-org-43 297 406 : : : en-wikipedia-org-43 297 407 Ersofermin Ersofermin NNP en-wikipedia-org-43 297 408 FGF FGF NNP en-wikipedia-org-43 297 409 ( ( -LRB- en-wikipedia-org-43 297 410 1 1 CD en-wikipedia-org-43 297 411 , , , en-wikipedia-org-43 297 412 2 2 CD en-wikipedia-org-43 297 413 ( ( -LRB- en-wikipedia-org-43 297 414 bFGF bfgf NN en-wikipedia-org-43 297 415 ) ) -RRB- en-wikipedia-org-43 297 416 , , , en-wikipedia-org-43 297 417 3 3 CD en-wikipedia-org-43 297 418 , , , en-wikipedia-org-43 297 419 4 4 CD en-wikipedia-org-43 297 420 , , , en-wikipedia-org-43 297 421 5 5 CD en-wikipedia-org-43 297 422 , , , en-wikipedia-org-43 297 423 6 6 CD en-wikipedia-org-43 297 424 , , , en-wikipedia-org-43 297 425 7 7 CD en-wikipedia-org-43 297 426 ( ( -LRB- en-wikipedia-org-43 297 427 KGF KGF NNP en-wikipedia-org-43 297 428 ) ) -RRB- en-wikipedia-org-43 297 429 , , , en-wikipedia-org-43 297 430 8 8 CD en-wikipedia-org-43 297 431 , , , en-wikipedia-org-43 297 432 9 9 CD en-wikipedia-org-43 297 433 , , , en-wikipedia-org-43 297 434 10 10 CD en-wikipedia-org-43 297 435 ( ( -LRB- en-wikipedia-org-43 297 436 KGF2 KGF2 NNP en-wikipedia-org-43 297 437 ) ) -RRB- en-wikipedia-org-43 297 438 , , , en-wikipedia-org-43 297 439 17 17 CD en-wikipedia-org-43 297 440 , , , en-wikipedia-org-43 297 441 18 18 CD en-wikipedia-org-43 297 442 , , , en-wikipedia-org-43 297 443 22 22 CD en-wikipedia-org-43 297 444 ) ) -RRB- en-wikipedia-org-43 297 445 Palifermin Palifermin NNP en-wikipedia-org-43 297 446 Repifermin Repifermin NNP en-wikipedia-org-43 297 447 Selpercatinib Selpercatinib NNP en-wikipedia-org-43 297 448 Sprifermin Sprifermin NNP en-wikipedia-org-43 297 449 Trafermin Trafermin NNP en-wikipedia-org-43 297 450 Antibodies Antibodies NNPS en-wikipedia-org-43 297 451 : : : en-wikipedia-org-43 297 452 Aprutumab Aprutumab NNP en-wikipedia-org-43 297 453 Aprutumab Aprutumab NNP en-wikipedia-org-43 297 454 ixadotin ixadotin NN en-wikipedia-org-43 297 455 FGFR3 FGFR3 NNP en-wikipedia-org-43 297 456 Agonists agonist NNS en-wikipedia-org-43 297 457 : : : en-wikipedia-org-43 297 458 Ersofermin Ersofermin NNP en-wikipedia-org-43 297 459 FGF FGF NNP en-wikipedia-org-43 297 460 ( ( -LRB- en-wikipedia-org-43 297 461 1 1 CD en-wikipedia-org-43 297 462 , , , en-wikipedia-org-43 297 463 2 2 CD en-wikipedia-org-43 297 464 ( ( -LRB- en-wikipedia-org-43 297 465 bFGF bfgf NN en-wikipedia-org-43 297 466 ) ) -RRB- en-wikipedia-org-43 297 467 , , , en-wikipedia-org-43 297 468 4 4 CD en-wikipedia-org-43 297 469 , , , en-wikipedia-org-43 297 470 8 8 CD en-wikipedia-org-43 297 471 , , , en-wikipedia-org-43 297 472 9 9 CD en-wikipedia-org-43 297 473 , , , en-wikipedia-org-43 297 474 18 18 CD en-wikipedia-org-43 297 475 , , , en-wikipedia-org-43 297 476 23 23 CD en-wikipedia-org-43 297 477 ) ) -RRB- en-wikipedia-org-43 297 478 Selpercatinib Selpercatinib NNP en-wikipedia-org-43 297 479 Sprifermin Sprifermin NNP en-wikipedia-org-43 297 480 Trafermin Trafermin NNP en-wikipedia-org-43 297 481 Antibodies Antibodies NNPS en-wikipedia-org-43 297 482 : : : en-wikipedia-org-43 297 483 Burosumab Burosumab NNP en-wikipedia-org-43 297 484 ( ( -LRB- en-wikipedia-org-43 297 485 against against IN en-wikipedia-org-43 297 486 FGF23 fgf23 NN en-wikipedia-org-43 297 487 ) ) -RRB- en-wikipedia-org-43 297 488 FGFR4 FGFR4 `` en-wikipedia-org-43 297 489 Agonists agonist NNS en-wikipedia-org-43 297 490 : : : en-wikipedia-org-43 297 491 Ersofermin Ersofermin NNP en-wikipedia-org-43 297 492 FGF FGF NNP en-wikipedia-org-43 297 493 ( ( -LRB- en-wikipedia-org-43 297 494 1 1 CD en-wikipedia-org-43 297 495 , , , en-wikipedia-org-43 297 496 2 2 CD en-wikipedia-org-43 297 497 ( ( -LRB- en-wikipedia-org-43 297 498 bFGF bfgf NN en-wikipedia-org-43 297 499 ) ) -RRB- en-wikipedia-org-43 297 500 , , , en-wikipedia-org-43 297 501 4 4 CD en-wikipedia-org-43 297 502 , , , en-wikipedia-org-43 297 503 6 6 CD en-wikipedia-org-43 297 504 , , , en-wikipedia-org-43 297 505 8 8 CD en-wikipedia-org-43 297 506 , , , en-wikipedia-org-43 297 507 9 9 CD en-wikipedia-org-43 297 508 , , , en-wikipedia-org-43 297 509 19 19 CD en-wikipedia-org-43 297 510 ) ) -RRB- en-wikipedia-org-43 297 511 Trafermin Trafermin NNP en-wikipedia-org-43 297 512 Unsorted unsorted JJ en-wikipedia-org-43 297 513 Agonists Agonists NNPS en-wikipedia-org-43 297 514 : : : en-wikipedia-org-43 297 515 FGF15/19 FGF15/19 NNP en-wikipedia-org-43 297 516 HGF HGF NNP en-wikipedia-org-43 297 517 ( ( -LRB- en-wikipedia-org-43 297 518 c c NN en-wikipedia-org-43 297 519 - - : en-wikipedia-org-43 297 520 Met Met NNP en-wikipedia-org-43 297 521 ) ) -RRB- en-wikipedia-org-43 297 522 Agonists agonist NNS en-wikipedia-org-43 297 523 : : : en-wikipedia-org-43 297 524 Hepatocyte hepatocyte JJ en-wikipedia-org-43 297 525 growth growth NN en-wikipedia-org-43 297 526 factor factor NN en-wikipedia-org-43 297 527 Potentiators potentiator NNS en-wikipedia-org-43 297 528 : : : en-wikipedia-org-43 297 529 Dihexa Dihexa NNP en-wikipedia-org-43 297 530 ( ( -LRB- en-wikipedia-org-43 297 531 PNB-0408 PNB-0408 NNP en-wikipedia-org-43 297 532 ) ) -RRB- en-wikipedia-org-43 297 533 Kinase Kinase NNP en-wikipedia-org-43 297 534 inhibitors inhibitor NNS en-wikipedia-org-43 297 535 : : : en-wikipedia-org-43 297 536 Altiratinib Altiratinib NNP en-wikipedia-org-43 297 537 AM7 AM7 NNP en-wikipedia-org-43 297 538 AMG-458 amg-458 XX en-wikipedia-org-43 297 539 Amuvatinib Amuvatinib NNP en-wikipedia-org-43 297 540 BMS-777607 BMS-777607 NNP en-wikipedia-org-43 297 541 Cabozantinib Cabozantinib NNP en-wikipedia-org-43 297 542 Capmatinib Capmatinib NNP en-wikipedia-org-43 297 543 Crizotinib Crizotinib NNP en-wikipedia-org-43 297 544 Foretinib Foretinib NNP en-wikipedia-org-43 297 545 Golvatinib Golvatinib NNP en-wikipedia-org-43 297 546 INCB28060 INCB28060 NNP en-wikipedia-org-43 297 547 JNJ-38877605 JNJ-38877605 NNP en-wikipedia-org-43 297 548 K252a K252a VBD en-wikipedia-org-43 297 549 MK-2461 mk-2461 NN en-wikipedia-org-43 297 550 PF-04217903 pf-04217903 NN en-wikipedia-org-43 297 551 PF-2341066 PF-2341066 NNS en-wikipedia-org-43 297 552 PHA-665752 PHA-665752 NNS en-wikipedia-org-43 297 553 SU-11274 SU-11274 VBN en-wikipedia-org-43 297 554 Tivantinib Tivantinib NNP en-wikipedia-org-43 297 555 Volitinib Volitinib NNP en-wikipedia-org-43 297 556 Antibodies antibody NNS en-wikipedia-org-43 297 557 : : : en-wikipedia-org-43 297 558 Emibetuzumab Emibetuzumab NNP en-wikipedia-org-43 297 559 Ficlatuzumab Ficlatuzumab NNS en-wikipedia-org-43 297 560 Flanvotumab Flanvotumab NNP en-wikipedia-org-43 297 561 Onartuzumab Onartuzumab NNP en-wikipedia-org-43 297 562 Rilotumumab Rilotumumab NNP en-wikipedia-org-43 297 563 Telisotuzumab Telisotuzumab NNP en-wikipedia-org-43 297 564 Telisotuzumab Telisotuzumab NNP en-wikipedia-org-43 297 565 vedotin vedotin VBP en-wikipedia-org-43 297 566 IGF IGF NNP en-wikipedia-org-43 297 567 IGF-1 IGF-1 NNP en-wikipedia-org-43 297 568 Agonists Agonists NNPS en-wikipedia-org-43 297 569 : : : en-wikipedia-org-43 297 570 des(1 des(1 NN en-wikipedia-org-43 297 571 - - HYPH en-wikipedia-org-43 297 572 3)IGF-1 3)igf-1 CD en-wikipedia-org-43 297 573 Insulin Insulin NNP en-wikipedia-org-43 297 574 - - HYPH en-wikipedia-org-43 297 575 like like JJ en-wikipedia-org-43 297 576 growth growth NN en-wikipedia-org-43 297 577 factor-1 factor-1 NNP en-wikipedia-org-43 297 578 ( ( -LRB- en-wikipedia-org-43 297 579 somatomedin somatomedin NNP en-wikipedia-org-43 297 580 C C NNP en-wikipedia-org-43 297 581 ) ) -RRB- en-wikipedia-org-43 297 582 IGF-1 IGF-1 NNP en-wikipedia-org-43 297 583 LR3 LR3 NNP en-wikipedia-org-43 297 584 Insulin Insulin NNP en-wikipedia-org-43 297 585 - - HYPH en-wikipedia-org-43 297 586 like like JJ en-wikipedia-org-43 297 587 growth growth NN en-wikipedia-org-43 297 588 factor-2 factor-2 NNP en-wikipedia-org-43 297 589 ( ( -LRB- en-wikipedia-org-43 297 590 somatomedin somatomedin NNP en-wikipedia-org-43 297 591 A a DT en-wikipedia-org-43 297 592 ) ) -RRB- en-wikipedia-org-43 297 593 Insulin Insulin NNP en-wikipedia-org-43 297 594 Mecasermin Mecasermin NNP en-wikipedia-org-43 297 595 Mecasermin Mecasermin NNP en-wikipedia-org-43 297 596 rinfabate rinfabate VBP en-wikipedia-org-43 297 597 Kinase Kinase NNP en-wikipedia-org-43 297 598 inhibitors inhibitor NNS en-wikipedia-org-43 297 599 : : : en-wikipedia-org-43 297 600 BMS-754807 BMS-754807 NNP en-wikipedia-org-43 297 601 Linsitinib Linsitinib NNP en-wikipedia-org-43 297 602 NVP NVP NNP en-wikipedia-org-43 297 603 - - HYPH en-wikipedia-org-43 297 604 ADW742 ADW742 NNP en-wikipedia-org-43 297 605 NVP NVP NNP en-wikipedia-org-43 297 606 - - HYPH en-wikipedia-org-43 297 607 AEW541 AEW541 NNP en-wikipedia-org-43 297 608 OSl-906 OSl-906 NNP en-wikipedia-org-43 297 609 Antibodies Antibodies NNPS en-wikipedia-org-43 297 610 : : : en-wikipedia-org-43 297 611 AVE-1642 AVE-1642 NNP en-wikipedia-org-43 297 612 Cixutumumab Cixutumumab NNP en-wikipedia-org-43 297 613 Dalotuzumab Dalotuzumab VBZ en-wikipedia-org-43 297 614 Figitumumab figitumumab NN en-wikipedia-org-43 297 615 Ganitumab Ganitumab NNP en-wikipedia-org-43 297 616 Robatumumab robatumumab JJ en-wikipedia-org-43 297 617 R1507 r1507 NN en-wikipedia-org-43 297 618 Teprotumumab Teprotumumab NNPS en-wikipedia-org-43 297 619 Xentuzumab Xentuzumab NNP en-wikipedia-org-43 297 620 ( ( -LRB- en-wikipedia-org-43 297 621 against against IN en-wikipedia-org-43 297 622 IGF-1 IGF-1 NNP en-wikipedia-org-43 297 623 and and CC en-wikipedia-org-43 297 624 IGF-2 IGF-2 NNP en-wikipedia-org-43 297 625 ) ) -RRB- en-wikipedia-org-43 297 626 IGF-2 IGF-2 NNP en-wikipedia-org-43 297 627 Agonists Agonists NNPS en-wikipedia-org-43 297 628 : : : en-wikipedia-org-43 297 629 Insulin Insulin NNP en-wikipedia-org-43 297 630 - - HYPH en-wikipedia-org-43 297 631 like like JJ en-wikipedia-org-43 297 632 growth growth NN en-wikipedia-org-43 297 633 factor-2 factor-2 NNP en-wikipedia-org-43 297 634 ( ( -LRB- en-wikipedia-org-43 297 635 somatomedin somatomedin NNP en-wikipedia-org-43 297 636 A a DT en-wikipedia-org-43 297 637 ) ) -RRB- en-wikipedia-org-43 297 638 Antibodies antibody NNS en-wikipedia-org-43 297 639 : : : en-wikipedia-org-43 297 640 Dusigitumab Dusigitumab NNP en-wikipedia-org-43 297 641 Xentuzumab Xentuzumab NNP en-wikipedia-org-43 297 642 ( ( -LRB- en-wikipedia-org-43 297 643 against against IN en-wikipedia-org-43 297 644 IGF-1 IGF-1 NNP en-wikipedia-org-43 297 645 and and CC en-wikipedia-org-43 297 646 IGF-2 IGF-2 NNP en-wikipedia-org-43 297 647 ) ) -RRB- en-wikipedia-org-43 297 648 Others other NNS en-wikipedia-org-43 297 649 Binding bind VBG en-wikipedia-org-43 297 650 proteins protein NNS en-wikipedia-org-43 297 651 : : : en-wikipedia-org-43 297 652 IGFBP IGFBP NNP en-wikipedia-org-43 297 653 ( ( -LRB- en-wikipedia-org-43 297 654 1 1 CD en-wikipedia-org-43 297 655 , , , en-wikipedia-org-43 297 656 2 2 CD en-wikipedia-org-43 297 657 , , , en-wikipedia-org-43 297 658 3 3 CD en-wikipedia-org-43 297 659 , , , en-wikipedia-org-43 297 660 4 4 CD en-wikipedia-org-43 297 661 , , , en-wikipedia-org-43 297 662 5 5 CD en-wikipedia-org-43 297 663 , , , en-wikipedia-org-43 297 664 6 6 CD en-wikipedia-org-43 297 665 , , , en-wikipedia-org-43 297 666 7 7 CD en-wikipedia-org-43 297 667 ) ) -RRB- en-wikipedia-org-43 297 668 Cleavage cleavage NN en-wikipedia-org-43 297 669 products product NNS en-wikipedia-org-43 297 670 / / SYM en-wikipedia-org-43 297 671 derivatives derivative NNS en-wikipedia-org-43 297 672 with with IN en-wikipedia-org-43 297 673 unknown unknown JJ en-wikipedia-org-43 297 674 target target NN en-wikipedia-org-43 297 675 : : : en-wikipedia-org-43 297 676 Glypromate Glypromate NNP en-wikipedia-org-43 297 677 ( ( -LRB- en-wikipedia-org-43 297 678 GPE GPE NNP en-wikipedia-org-43 297 679 , , , en-wikipedia-org-43 297 680 ( ( -LRB- en-wikipedia-org-43 297 681 1 1 CD en-wikipedia-org-43 297 682 - - SYM en-wikipedia-org-43 297 683 3)IGF-1 3)igf-1 CD en-wikipedia-org-43 297 684 ) ) -RRB- en-wikipedia-org-43 297 685 Trofinetide Trofinetide NNP en-wikipedia-org-43 297 686 LNGF LNGF NNP en-wikipedia-org-43 297 687 ( ( -LRB- en-wikipedia-org-43 297 688 p75NTR p75ntr NN en-wikipedia-org-43 297 689 ) ) -RRB- en-wikipedia-org-43 297 690 Agonists agonist NNS en-wikipedia-org-43 297 691 : : : en-wikipedia-org-43 297 692 BDNF BDNF NNP en-wikipedia-org-43 297 693 BNN-20 bnn-20 UH en-wikipedia-org-43 297 694 BNN-27 bnn-27 CD en-wikipedia-org-43 297 695 Cenegermin Cenegermin NNP en-wikipedia-org-43 297 696 DHEA DHEA NNP en-wikipedia-org-43 297 697 DHEA DHEA NNP en-wikipedia-org-43 297 698 - - HYPH en-wikipedia-org-43 297 699 S S NNP en-wikipedia-org-43 297 700 NGF NGF NNP en-wikipedia-org-43 297 701 NT-3 NT-3 NNP en-wikipedia-org-43 297 702 NT-4 NT-4 NNP en-wikipedia-org-43 297 703 Antagonists Antagonists NNPS en-wikipedia-org-43 297 704 : : : en-wikipedia-org-43 297 705 ALE-0540 ALE-0540 NNP en-wikipedia-org-43 297 706 Dexamethasone Dexamethasone NNP en-wikipedia-org-43 297 707 EVT-901 evt-901 NN en-wikipedia-org-43 297 708 ( ( -LRB- en-wikipedia-org-43 297 709 SAR-127963 SAR-127963 NNP en-wikipedia-org-43 297 710 ) ) -RRB- en-wikipedia-org-43 297 711 Testosterone Testosterone NNP en-wikipedia-org-43 297 712 Antibodies antibody NNS en-wikipedia-org-43 297 713 : : : en-wikipedia-org-43 297 714 Against against IN en-wikipedia-org-43 297 715 NGF NGF NNP en-wikipedia-org-43 297 716 : : : en-wikipedia-org-43 297 717 ABT-110 ABT-110 NNP en-wikipedia-org-43 297 718 ( ( -LRB- en-wikipedia-org-43 297 719 PG110 PG110 NNP en-wikipedia-org-43 297 720 ) ) -RRB- en-wikipedia-org-43 297 721 ASP-6294 ASP-6294 NNP en-wikipedia-org-43 297 722 Fasinumab Fasinumab NNP en-wikipedia-org-43 297 723 Frunevetmab Frunevetmab NNP en-wikipedia-org-43 297 724 Fulranumab fulranumab NN en-wikipedia-org-43 297 725 MEDI-578 medi-578 NN en-wikipedia-org-43 297 726 Ranevetmab Ranevetmab NNP en-wikipedia-org-43 297 727 Tanezumab Tanezumab NNP en-wikipedia-org-43 297 728 Aptamers aptamer NNS en-wikipedia-org-43 297 729 : : : en-wikipedia-org-43 297 730 Against against IN en-wikipedia-org-43 297 731 NGF NGF NNP en-wikipedia-org-43 297 732 : : : en-wikipedia-org-43 297 733 RBM-004 RBM-004 NNP en-wikipedia-org-43 297 734 Decoy Decoy NNP en-wikipedia-org-43 297 735 receptors receptor NNS en-wikipedia-org-43 297 736 : : : en-wikipedia-org-43 297 737 LEVI-04 LEVI-04 NNP en-wikipedia-org-43 297 738 ( ( -LRB- en-wikipedia-org-43 297 739 p75NTR p75NTR NNP en-wikipedia-org-43 297 740 - - HYPH en-wikipedia-org-43 297 741 Fc Fc NNP en-wikipedia-org-43 297 742 ) ) -RRB- en-wikipedia-org-43 297 743 PDGF PDGF NNP en-wikipedia-org-43 297 744 Agonists agonist NNS en-wikipedia-org-43 297 745 : : : en-wikipedia-org-43 297 746 Becaplermin Becaplermin NNP en-wikipedia-org-43 297 747 Platelet Platelet NNP en-wikipedia-org-43 297 748 - - HYPH en-wikipedia-org-43 297 749 derived derive VBN en-wikipedia-org-43 297 750 growth growth NN en-wikipedia-org-43 297 751 factor factor NN en-wikipedia-org-43 297 752 ( ( -LRB- en-wikipedia-org-43 297 753 A a NN en-wikipedia-org-43 297 754 , , , en-wikipedia-org-43 297 755 B b NN en-wikipedia-org-43 297 756 , , , en-wikipedia-org-43 297 757 C C NNP en-wikipedia-org-43 297 758 , , , en-wikipedia-org-43 297 759 D D NNP en-wikipedia-org-43 297 760 ) ) -RRB- en-wikipedia-org-43 297 761 Kinase Kinase NNP en-wikipedia-org-43 297 762 inhibitors inhibitor NNS en-wikipedia-org-43 297 763 : : : en-wikipedia-org-43 297 764 Agerafenib agerafenib JJ en-wikipedia-org-43 297 765 Axitinib Axitinib NNP en-wikipedia-org-43 297 766 Crenolanib Crenolanib NNP en-wikipedia-org-43 297 767 Imatinib Imatinib NNP en-wikipedia-org-43 297 768 Lenvatinib Lenvatinib NNP en-wikipedia-org-43 297 769 Masitinib Masitinib NNP en-wikipedia-org-43 297 770 Motesanib Motesanib NNP en-wikipedia-org-43 297 771 Nintedanib Nintedanib NNP en-wikipedia-org-43 297 772 Pazopanib Pazopanib NNP en-wikipedia-org-43 297 773 Radotinib Radotinib NNP en-wikipedia-org-43 297 774 Quizartinib Quizartinib NNP en-wikipedia-org-43 297 775 Ripretinib Ripretinib NNP en-wikipedia-org-43 297 776 Sunitinib Sunitinib NNP en-wikipedia-org-43 297 777 Sorafenib Sorafenib NNP en-wikipedia-org-43 297 778 Toceranib Toceranib NNP en-wikipedia-org-43 297 779 Antibodies Antibodies NNPS en-wikipedia-org-43 297 780 : : : en-wikipedia-org-43 297 781 Olaratumab Olaratumab NNP en-wikipedia-org-43 297 782 Ramucirumab Ramucirumab NNP en-wikipedia-org-43 297 783 Tovetumab Tovetumab NNP en-wikipedia-org-43 297 784 RET RET NNP en-wikipedia-org-43 297 785 ( ( -LRB- en-wikipedia-org-43 297 786 GFL GFL NNP en-wikipedia-org-43 297 787 ) ) -RRB- en-wikipedia-org-43 297 788 GFRα1 GFRα1 NNP en-wikipedia-org-43 297 789 Agonists Agonists NNPS en-wikipedia-org-43 297 790 : : : en-wikipedia-org-43 297 791 Glial glial JJ en-wikipedia-org-43 297 792 cell cell NN en-wikipedia-org-43 297 793 line line NN en-wikipedia-org-43 297 794 - - HYPH en-wikipedia-org-43 297 795 derived derive VBN en-wikipedia-org-43 297 796 neurotrophic neurotrophic JJ en-wikipedia-org-43 297 797 factor factor NN en-wikipedia-org-43 297 798 ( ( -LRB- en-wikipedia-org-43 297 799 GDNF GDNF NNP en-wikipedia-org-43 297 800 ) ) -RRB- en-wikipedia-org-43 297 801 Liatermin Liatermin NNP en-wikipedia-org-43 297 802 Kinase Kinase NNP en-wikipedia-org-43 297 803 inhibitors inhibitor NNS en-wikipedia-org-43 297 804 : : : en-wikipedia-org-43 297 805 Vandetanib Vandetanib NNP en-wikipedia-org-43 297 806 GFRα2 GFRα2 NNP en-wikipedia-org-43 297 807 Agonists Agonists NNPS en-wikipedia-org-43 297 808 : : : en-wikipedia-org-43 297 809 Neurturin Neurturin NNP en-wikipedia-org-43 297 810 ( ( -LRB- en-wikipedia-org-43 297 811 NRTN NRTN NNP en-wikipedia-org-43 297 812 ) ) -RRB- en-wikipedia-org-43 297 813 Kinase Kinase NNP en-wikipedia-org-43 297 814 inhibitors inhibitor NNS en-wikipedia-org-43 297 815 : : : en-wikipedia-org-43 297 816 Vandetanib Vandetanib NNP en-wikipedia-org-43 297 817 GFRα3 GFRα3 NNP en-wikipedia-org-43 297 818 Agonists Agonists NNPS en-wikipedia-org-43 297 819 : : : en-wikipedia-org-43 297 820 Artemin Artemin NNP en-wikipedia-org-43 297 821 ( ( -LRB- en-wikipedia-org-43 297 822 ARTN ARTN NNP en-wikipedia-org-43 297 823 ) ) -RRB- en-wikipedia-org-43 297 824 Kinase Kinase NNP en-wikipedia-org-43 297 825 inhibitors inhibitor NNS en-wikipedia-org-43 297 826 : : : en-wikipedia-org-43 297 827 Vandetanib Vandetanib NNP en-wikipedia-org-43 297 828 GFRα4 GFRα4 NNP en-wikipedia-org-43 297 829 Agonists Agonists NNPS en-wikipedia-org-43 297 830 : : : en-wikipedia-org-43 297 831 Persephin Persephin NNP en-wikipedia-org-43 297 832 ( ( -LRB- en-wikipedia-org-43 297 833 PSPN PSPN NNP en-wikipedia-org-43 297 834 ) ) -RRB- en-wikipedia-org-43 297 835 Kinase Kinase NNP en-wikipedia-org-43 297 836 inhibitors inhibitor NNS en-wikipedia-org-43 297 837 : : : en-wikipedia-org-43 297 838 Vandetanib Vandetanib NNP en-wikipedia-org-43 297 839 Unsorted Unsorted NNP en-wikipedia-org-43 297 840 Kinase Kinase NNP en-wikipedia-org-43 297 841 inhibitors inhibitor NNS en-wikipedia-org-43 297 842 : : : en-wikipedia-org-43 297 843 Agerafenib agerafenib JJ en-wikipedia-org-43 297 844 SCF SCF NNP en-wikipedia-org-43 297 845 ( ( -LRB- en-wikipedia-org-43 297 846 c c NN en-wikipedia-org-43 297 847 - - HYPH en-wikipedia-org-43 297 848 Kit Kit NNP en-wikipedia-org-43 297 849 ) ) -RRB- en-wikipedia-org-43 297 850 Agonists agonist NNS en-wikipedia-org-43 297 851 : : : en-wikipedia-org-43 297 852 Ancestim Ancestim NNP en-wikipedia-org-43 297 853 Stem Stem NNP en-wikipedia-org-43 297 854 cell cell NN en-wikipedia-org-43 297 855 factor factor NN en-wikipedia-org-43 297 856 Kinase Kinase NNP en-wikipedia-org-43 297 857 inhibitors inhibitor NNS en-wikipedia-org-43 297 858 : : : en-wikipedia-org-43 297 859 Agerafenib agerafenib JJ en-wikipedia-org-43 297 860 Axitinib Axitinib NNP en-wikipedia-org-43 297 861 Dasatinib Dasatinib NNP en-wikipedia-org-43 297 862 Imatinib Imatinib NNP en-wikipedia-org-43 297 863 Masitinib Masitinib NNP en-wikipedia-org-43 297 864 Nilotinib Nilotinib NNP en-wikipedia-org-43 297 865 Pazopanib Pazopanib NNP en-wikipedia-org-43 297 866 Quizartinib Quizartinib NNP en-wikipedia-org-43 297 867 Sorafenib Sorafenib NNP en-wikipedia-org-43 297 868 Sunitinib Sunitinib NNP en-wikipedia-org-43 297 869 Toceranib Toceranib NNP en-wikipedia-org-43 297 870 TGFβ TGFβ NNPS en-wikipedia-org-43 297 871 See see VBP en-wikipedia-org-43 297 872 here here RB en-wikipedia-org-43 297 873 instead instead RB en-wikipedia-org-43 297 874 . . . en-wikipedia-org-43 298 1 Trk trk VB en-wikipedia-org-43 298 2 TrkA TrkA NNP en-wikipedia-org-43 298 3 Agonists agonist NNS en-wikipedia-org-43 298 4 : : : en-wikipedia-org-43 298 5 Amitriptyline amitriptyline NN en-wikipedia-org-43 298 6 BNN-20 bnn-20 NN en-wikipedia-org-43 298 7 BNN-27 bnn-27 CD en-wikipedia-org-43 298 8 Cenegermin Cenegermin NNP en-wikipedia-org-43 298 9 DHEA DHEA NNP en-wikipedia-org-43 298 10 DHEA dhea NN en-wikipedia-org-43 298 11 - - HYPH en-wikipedia-org-43 298 12 S S NNP en-wikipedia-org-43 298 13 Gambogic gambogic JJ en-wikipedia-org-43 298 14 amide amide NN en-wikipedia-org-43 298 15 NGF NGF NNP en-wikipedia-org-43 298 16 Tavilermide Tavilermide NNP en-wikipedia-org-43 298 17 Antagonists Antagonists NNPS en-wikipedia-org-43 298 18 : : : en-wikipedia-org-43 298 19 ALE-0540 ALE-0540 NNP en-wikipedia-org-43 298 20 Dexamethasone Dexamethasone NNP en-wikipedia-org-43 298 21 FX007 fx007 NN en-wikipedia-org-43 298 22 Testosterone Testosterone NNP en-wikipedia-org-43 298 23 Negative negative JJ en-wikipedia-org-43 298 24 allosteric allosteric JJ en-wikipedia-org-43 298 25 modulators modulator NNS en-wikipedia-org-43 298 26 : : : en-wikipedia-org-43 298 27 VM-902A vm-902a RB en-wikipedia-org-43 298 28 Kinase Kinase NNP en-wikipedia-org-43 298 29 inhibitors inhibitor NNS en-wikipedia-org-43 298 30 : : : en-wikipedia-org-43 298 31 Altiratinib Altiratinib NNP en-wikipedia-org-43 298 32 AZD-6918 AZD-6918 NNP en-wikipedia-org-43 298 33 CE-245677 CE-245677 NNP en-wikipedia-org-43 298 34 CH-7057288 CH-7057288 NNP en-wikipedia-org-43 298 35 DS-6051 DS-6051 VBZ en-wikipedia-org-43 298 36 Entrectinib Entrectinib NNP en-wikipedia-org-43 298 37 GZ-389988 GZ-389988 NNP en-wikipedia-org-43 298 38 K252a K252a VBD en-wikipedia-org-43 298 39 Larotrectinib Larotrectinib NNP en-wikipedia-org-43 298 40 Lestaurtinib Lestaurtinib NNP en-wikipedia-org-43 298 41 Milciclib Milciclib NNP en-wikipedia-org-43 298 42 ONO-4474 ONO-4474 NNP en-wikipedia-org-43 298 43 ONO-5390556 ONO-5390556 NNP en-wikipedia-org-43 298 44 PLX-7486 PLX-7486 NNP en-wikipedia-org-43 298 45 Rebastinib Rebastinib NNP en-wikipedia-org-43 298 46 SNA-120 SNA-120 NNP en-wikipedia-org-43 298 47 ( ( -LRB- en-wikipedia-org-43 298 48 pegylated pegylate VBN en-wikipedia-org-43 298 49 K252a K252a NNP en-wikipedia-org-43 298 50 ) ) -RRB- en-wikipedia-org-43 298 51 ) ) -RRB- en-wikipedia-org-43 298 52 Antibodies antibody NNS en-wikipedia-org-43 298 53 : : : en-wikipedia-org-43 298 54 Against against IN en-wikipedia-org-43 298 55 TrkA TrkA NNP en-wikipedia-org-43 298 56 : : : en-wikipedia-org-43 298 57 GBR-900 gbr-900 UH en-wikipedia-org-43 298 58 ; ; : en-wikipedia-org-43 298 59 Against against IN en-wikipedia-org-43 298 60 NGF NGF NNP en-wikipedia-org-43 298 61 : : : en-wikipedia-org-43 298 62 ABT-110 ABT-110 NNP en-wikipedia-org-43 298 63 ( ( -LRB- en-wikipedia-org-43 298 64 PG110 PG110 NNP en-wikipedia-org-43 298 65 ) ) -RRB- en-wikipedia-org-43 298 66 ASP-6294 ASP-6294 NNP en-wikipedia-org-43 298 67 Fasinumab Fasinumab NNP en-wikipedia-org-43 298 68 Frunevetmab Frunevetmab NNP en-wikipedia-org-43 298 69 Fulranumab fulranumab NN en-wikipedia-org-43 298 70 MEDI-578 medi-578 NN en-wikipedia-org-43 298 71 Ranevetmab Ranevetmab NNP en-wikipedia-org-43 298 72 Tanezumab Tanezumab NNP en-wikipedia-org-43 298 73 Aptamers aptamer NNS en-wikipedia-org-43 298 74 : : : en-wikipedia-org-43 298 75 Against against IN en-wikipedia-org-43 298 76 NGF NGF NNP en-wikipedia-org-43 298 77 : : : en-wikipedia-org-43 298 78 RBM-004 RBM-004 NNP en-wikipedia-org-43 298 79 Decoy Decoy NNP en-wikipedia-org-43 298 80 receptors receptor NNS en-wikipedia-org-43 298 81 : : : en-wikipedia-org-43 298 82 ReN-1820 ren-1820 CD en-wikipedia-org-43 298 83 ( ( -LRB- en-wikipedia-org-43 298 84 TrkAd5 trkad5 ADD en-wikipedia-org-43 298 85 ) ) -RRB- en-wikipedia-org-43 298 86 TrkB TrkB NNP en-wikipedia-org-43 298 87 Agonists agonist NNS en-wikipedia-org-43 298 88 : : : en-wikipedia-org-43 298 89 3,7-DHF 3,7-dhf NN en-wikipedia-org-43 298 90 3,7,8,2'-THF 3,7,8,2'-thf CD en-wikipedia-org-43 298 91 4'-DMA-7,8-DHF 4'-dma-7,8-dhf CD en-wikipedia-org-43 298 92 7,3'-DHF 7,3'-dhf CD en-wikipedia-org-43 298 93 7,8-DHF 7,8-dhf CD en-wikipedia-org-43 298 94 7,8,2'-THF 7,8,2'-thf JJ en-wikipedia-org-43 298 95 7,8,3'-THF 7,8,3'-THF NNP en-wikipedia-org-43 298 96 Amitriptyline Amitriptyline NNP en-wikipedia-org-43 298 97 BDNF BDNF NNP en-wikipedia-org-43 298 98 BNN-20 bnn-20 CD en-wikipedia-org-43 298 99 Deoxygedunin Deoxygedunin NNP en-wikipedia-org-43 298 100 Deprenyl Deprenyl NNP en-wikipedia-org-43 298 101 Diosmetin Diosmetin NNP en-wikipedia-org-43 298 102 DMAQ DMAQ NNP en-wikipedia-org-43 298 103 - - HYPH en-wikipedia-org-43 298 104 B1 b1 NN en-wikipedia-org-43 298 105 HIOC HIOC NNS en-wikipedia-org-43 298 106 LM22A-4 LM22A-4 NNP en-wikipedia-org-43 298 107 N N NNP en-wikipedia-org-43 298 108 - - HYPH en-wikipedia-org-43 298 109 Acetylserotonin Acetylserotonin NNP en-wikipedia-org-43 298 110 NT-3 NT-3 NNP en-wikipedia-org-43 298 111 NT-4 NT-4 NNP en-wikipedia-org-43 298 112 Norwogonin Norwogonin NNP en-wikipedia-org-43 298 113 ( ( -LRB- en-wikipedia-org-43 298 114 5,7,8-THF 5,7,8-THF NNP en-wikipedia-org-43 298 115 ) ) -RRB- en-wikipedia-org-43 298 116 R7 R7 NNP en-wikipedia-org-43 298 117 R13 R13 NNP en-wikipedia-org-43 298 118 TDP6 TDP6 NNP en-wikipedia-org-43 298 119 Antagonists Antagonists NNPS en-wikipedia-org-43 298 120 : : : en-wikipedia-org-43 298 121 ANA-12 ANA-12 NNP en-wikipedia-org-43 298 122 Cyclotraxin Cyclotraxin NNP en-wikipedia-org-43 298 123 B B NNP en-wikipedia-org-43 298 124 Gossypetin Gossypetin NNP en-wikipedia-org-43 298 125 ( ( -LRB- en-wikipedia-org-43 298 126 3,5,7,8,3',4'-HHF 3,5,7,8,3',4'-HHF NNP en-wikipedia-org-43 298 127 ) ) -RRB- en-wikipedia-org-43 298 128 Ligands ligand NNS en-wikipedia-org-43 298 129 : : : en-wikipedia-org-43 298 130 DHEA DHEA NNP en-wikipedia-org-43 298 131 Kinase Kinase NNP en-wikipedia-org-43 298 132 inhibitors inhibitor NNS en-wikipedia-org-43 298 133 : : : en-wikipedia-org-43 298 134 Altiratinib Altiratinib NNP en-wikipedia-org-43 298 135 AZD-6918 AZD-6918 NNP en-wikipedia-org-43 298 136 CE-245677 CE-245677 NNP en-wikipedia-org-43 298 137 CH-7057288 CH-7057288 NNP en-wikipedia-org-43 298 138 DS-6051 DS-6051 VBZ en-wikipedia-org-43 298 139 Entrectinib Entrectinib NNP en-wikipedia-org-43 298 140 GZ-389988 GZ-389988 NNP en-wikipedia-org-43 298 141 K252a K252a VBD en-wikipedia-org-43 298 142 Larotrectinib Larotrectinib NNP en-wikipedia-org-43 298 143 Lestaurtinib Lestaurtinib NNP en-wikipedia-org-43 298 144 ONO-4474 ONO-4474 NNP en-wikipedia-org-43 298 145 ONO-5390556 ONO-5390556 NNP en-wikipedia-org-43 298 146 PLX-7486 PLX-7486 NNP en-wikipedia-org-43 298 147 TrkC TrkC NNP en-wikipedia-org-43 298 148 Agonists Agonists NNPS en-wikipedia-org-43 298 149 : : : en-wikipedia-org-43 298 150 BNN-20 BNN-20 JJR en-wikipedia-org-43 298 151 DHEA DHEA NNP en-wikipedia-org-43 298 152 NT-3 NT-3 NNP en-wikipedia-org-43 298 153 Kinase Kinase NNP en-wikipedia-org-43 298 154 inhibitors inhibitor NNS en-wikipedia-org-43 298 155 : : : en-wikipedia-org-43 298 156 Altiratinib Altiratinib NNP en-wikipedia-org-43 298 157 AZD-6918 AZD-6918 NNP en-wikipedia-org-43 298 158 CE-245677 CE-245677 NNP en-wikipedia-org-43 298 159 CH-7057288 CH-7057288 NNP en-wikipedia-org-43 298 160 DS-6051 DS-6051 VBZ en-wikipedia-org-43 298 161 Entrectinib Entrectinib NNP en-wikipedia-org-43 298 162 GZ-389988 GZ-389988 NNP en-wikipedia-org-43 298 163 K252a K252a VBD en-wikipedia-org-43 298 164 Larotrectinib Larotrectinib NNP en-wikipedia-org-43 298 165 Lestaurtinib Lestaurtinib NNP en-wikipedia-org-43 298 166 ONO-4474 ONO-4474 NNP en-wikipedia-org-43 298 167 ONO-5390556 ONO-5390556 NNP en-wikipedia-org-43 298 168 PLX-7486 PLX-7486 NNP en-wikipedia-org-43 298 169 VEGF vegf NN en-wikipedia-org-43 298 170 Agonists agonist NNS en-wikipedia-org-43 298 171 : : : en-wikipedia-org-43 298 172 Placental placental JJ en-wikipedia-org-43 298 173 growth growth NN en-wikipedia-org-43 298 174 factor factor NN en-wikipedia-org-43 298 175 ( ( -LRB- en-wikipedia-org-43 298 176 PGF PGF NNP en-wikipedia-org-43 298 177 ) ) -RRB- en-wikipedia-org-43 298 178 Ripretinib Ripretinib NNP en-wikipedia-org-43 298 179 Telbermin Telbermin NNP en-wikipedia-org-43 298 180 VEGF VEGF NNP en-wikipedia-org-43 298 181 ( ( -LRB- en-wikipedia-org-43 298 182 A a NN en-wikipedia-org-43 298 183 , , , en-wikipedia-org-43 298 184 B b NN en-wikipedia-org-43 298 185 , , , en-wikipedia-org-43 298 186 C c NN en-wikipedia-org-43 298 187 , , , en-wikipedia-org-43 298 188 D D NNP en-wikipedia-org-43 298 189 ( ( -LRB- en-wikipedia-org-43 298 190 FIGF FIGF NNP en-wikipedia-org-43 298 191 ) ) -RRB- en-wikipedia-org-43 298 192 ) ) -RRB- en-wikipedia-org-43 298 193 Allosteric allosteric JJ en-wikipedia-org-43 298 194 modulators modulator NNS en-wikipedia-org-43 298 195 : : : en-wikipedia-org-43 298 196 Cyclotraxin Cyclotraxin NNP en-wikipedia-org-43 298 197 B B NNP en-wikipedia-org-43 298 198 Kinase Kinase NNP en-wikipedia-org-43 298 199 inhibitors inhibitor NNS en-wikipedia-org-43 298 200 : : : en-wikipedia-org-43 298 201 Agerafenib agerafenib JJ en-wikipedia-org-43 298 202 Altiratinib Altiratinib NNP en-wikipedia-org-43 298 203 Axitinib Axitinib NNP en-wikipedia-org-43 298 204 Cabozantinib Cabozantinib NNP en-wikipedia-org-43 298 205 Cediranib Cediranib NNP en-wikipedia-org-43 298 206 Lapatinib Lapatinib NNP en-wikipedia-org-43 298 207 Lenvatinib Lenvatinib NNP en-wikipedia-org-43 298 208 Motesanib Motesanib NNP en-wikipedia-org-43 298 209 Nintedanib Nintedanib NNP en-wikipedia-org-43 298 210 Pazopanib Pazopanib NNP en-wikipedia-org-43 298 211 Pegaptanib Pegaptanib NNP en-wikipedia-org-43 298 212 Rebastinib Rebastinib NNP en-wikipedia-org-43 298 213 Regorafenib Regorafenib NNP en-wikipedia-org-43 298 214 Semaxanib Semaxanib NNP en-wikipedia-org-43 298 215 Sorafenib Sorafenib NNP en-wikipedia-org-43 298 216 Sunitinib Sunitinib NNP en-wikipedia-org-43 298 217 Toceranib Toceranib NNP en-wikipedia-org-43 298 218 Tivozanib Tivozanib NNP en-wikipedia-org-43 298 219 Vandetanib Vandetanib NNP en-wikipedia-org-43 298 220 WHI WHI NNP en-wikipedia-org-43 298 221 - - HYPH en-wikipedia-org-43 298 222 P P NNP en-wikipedia-org-43 298 223 154 154 CD en-wikipedia-org-43 298 224 Antibodies antibody NNS en-wikipedia-org-43 298 225 : : : en-wikipedia-org-43 298 226 Alacizumab Alacizumab NNP en-wikipedia-org-43 298 227 pegol pegol VBP en-wikipedia-org-43 298 228 Bevacizumab Bevacizumab NNP en-wikipedia-org-43 298 229 Icrucumab Icrucumab NNP en-wikipedia-org-43 298 230 Ramucirumab Ramucirumab NNP en-wikipedia-org-43 298 231 Ranibizumab Ranibizumab NNP en-wikipedia-org-43 298 232 Decoy Decoy NNP en-wikipedia-org-43 298 233 receptors receptor NNS en-wikipedia-org-43 298 234 : : : en-wikipedia-org-43 298 235 Aflibercept aflibercept VB en-wikipedia-org-43 298 236 Others other NNS en-wikipedia-org-43 298 237 Additional additional JJ en-wikipedia-org-43 298 238 growth growth NN en-wikipedia-org-43 298 239 factors factor NNS en-wikipedia-org-43 298 240 : : : en-wikipedia-org-43 298 241 Adrenomedullin Adrenomedullin NNP en-wikipedia-org-43 298 242 Colony Colony NNP en-wikipedia-org-43 298 243 - - HYPH en-wikipedia-org-43 298 244 stimulating stimulate VBG en-wikipedia-org-43 298 245 factors factor NNS en-wikipedia-org-43 298 246 ( ( -LRB- en-wikipedia-org-43 298 247 see see VB en-wikipedia-org-43 298 248 here here RB en-wikipedia-org-43 298 249 instead instead RB en-wikipedia-org-43 298 250 ) ) -RRB- en-wikipedia-org-43 298 251 Connective connective JJ en-wikipedia-org-43 298 252 tissue tissue NN en-wikipedia-org-43 298 253 growth growth NN en-wikipedia-org-43 298 254 factor factor NN en-wikipedia-org-43 298 255 ( ( -LRB- en-wikipedia-org-43 298 256 CTGF CTGF NNP en-wikipedia-org-43 298 257 ) ) -RRB- en-wikipedia-org-43 298 258 Ephrins Ephrins NNP en-wikipedia-org-43 298 259 ( ( -LRB- en-wikipedia-org-43 298 260 A1 A1 NNP en-wikipedia-org-43 298 261 , , , en-wikipedia-org-43 298 262 A2 A2 NNP en-wikipedia-org-43 298 263 , , , en-wikipedia-org-43 298 264 A3 A3 NNP en-wikipedia-org-43 298 265 , , , en-wikipedia-org-43 298 266 A4 A4 NNP en-wikipedia-org-43 298 267 , , , en-wikipedia-org-43 298 268 A5 A5 NNP en-wikipedia-org-43 298 269 , , , en-wikipedia-org-43 298 270 B1 b1 NN en-wikipedia-org-43 298 271 , , , en-wikipedia-org-43 298 272 B2 b2 NN en-wikipedia-org-43 298 273 , , , en-wikipedia-org-43 298 274 B3 b3 NN en-wikipedia-org-43 298 275 ) ) -RRB- en-wikipedia-org-43 298 276 Erythropoietin Erythropoietin NNP en-wikipedia-org-43 298 277 ( ( -LRB- en-wikipedia-org-43 298 278 see see VB en-wikipedia-org-43 298 279 here here RB en-wikipedia-org-43 298 280 instead instead RB en-wikipedia-org-43 298 281 ) ) -RRB- en-wikipedia-org-43 298 282 Glucose-6-phosphate glucose-6-phosphate VB en-wikipedia-org-43 298 283 isomerase isomerase NN en-wikipedia-org-43 298 284 ( ( -LRB- en-wikipedia-org-43 298 285 GPI GPI NNP en-wikipedia-org-43 298 286 ; ; : en-wikipedia-org-43 298 287 PGI PGI NNP en-wikipedia-org-43 298 288 , , , en-wikipedia-org-43 298 289 PHI PHI NNP en-wikipedia-org-43 298 290 , , , en-wikipedia-org-43 298 291 AMF AMF NNP en-wikipedia-org-43 298 292 ) ) -RRB- en-wikipedia-org-43 298 293 Glia Glia NNP en-wikipedia-org-43 298 294 maturation maturation NN en-wikipedia-org-43 298 295 factor factor NN en-wikipedia-org-43 298 296 ( ( -LRB- en-wikipedia-org-43 298 297 GMF GMF NNP en-wikipedia-org-43 298 298 ) ) -RRB- en-wikipedia-org-43 298 299 Hepatoma Hepatoma NNP en-wikipedia-org-43 298 300 - - HYPH en-wikipedia-org-43 298 301 derived derive VBN en-wikipedia-org-43 298 302 growth growth NN en-wikipedia-org-43 298 303 factor factor NN en-wikipedia-org-43 298 304 ( ( -LRB- en-wikipedia-org-43 298 305 HDGF HDGF NNP en-wikipedia-org-43 298 306 ) ) -RRB- en-wikipedia-org-43 298 307 Interleukins Interleukins NNP en-wikipedia-org-43 298 308 / / SYM en-wikipedia-org-43 298 309 T t NN en-wikipedia-org-43 298 310 - - HYPH en-wikipedia-org-43 298 311 cell cell NN en-wikipedia-org-43 298 312 growth growth NN en-wikipedia-org-43 298 313 factors factor NNS en-wikipedia-org-43 298 314 ( ( -LRB- en-wikipedia-org-43 298 315 see see VB en-wikipedia-org-43 298 316 here here RB en-wikipedia-org-43 298 317 instead instead RB en-wikipedia-org-43 298 318 ) ) -RRB- en-wikipedia-org-43 298 319 Leukemia Leukemia NNP en-wikipedia-org-43 298 320 inhibitory inhibitory NN en-wikipedia-org-43 298 321 factor factor NN en-wikipedia-org-43 298 322 ( ( -LRB- en-wikipedia-org-43 298 323 LIF LIF NNP en-wikipedia-org-43 298 324 ) ) -RRB- en-wikipedia-org-43 298 325 Macrophage macrophage NN en-wikipedia-org-43 298 326 - - HYPH en-wikipedia-org-43 298 327 stimulating stimulate VBG en-wikipedia-org-43 298 328 protein protein NN en-wikipedia-org-43 298 329 ( ( -LRB- en-wikipedia-org-43 298 330 MSP MSP NNP en-wikipedia-org-43 298 331 ; ; : en-wikipedia-org-43 298 332 HLP HLP NNP en-wikipedia-org-43 298 333 , , , en-wikipedia-org-43 298 334 HGFLP HGFLP NNP en-wikipedia-org-43 298 335 ) ) -RRB- en-wikipedia-org-43 298 336 Midkine Midkine NNP en-wikipedia-org-43 298 337 ( ( -LRB- en-wikipedia-org-43 298 338 NEGF2 NEGF2 NNP en-wikipedia-org-43 298 339 ) ) -RRB- en-wikipedia-org-43 298 340 Migration migration NN en-wikipedia-org-43 298 341 - - HYPH en-wikipedia-org-43 298 342 stimulating stimulate VBG en-wikipedia-org-43 298 343 factor factor NN en-wikipedia-org-43 298 344 ( ( -LRB- en-wikipedia-org-43 298 345 MSF MSF NNP en-wikipedia-org-43 298 346 ; ; : en-wikipedia-org-43 298 347 PRG4 PRG4 NNP en-wikipedia-org-43 298 348 ) ) -RRB- en-wikipedia-org-43 298 349 Oncomodulin Oncomodulin NNP en-wikipedia-org-43 298 350 Pituitary Pituitary NNP en-wikipedia-org-43 298 351 adenylate adenylate NN en-wikipedia-org-43 298 352 cyclase cyclase NN en-wikipedia-org-43 298 353 - - HYPH en-wikipedia-org-43 298 354 activating activate VBG en-wikipedia-org-43 298 355 peptide peptide NN en-wikipedia-org-43 298 356 ( ( -LRB- en-wikipedia-org-43 298 357 PACAP PACAP NNP en-wikipedia-org-43 298 358 ) ) -RRB- en-wikipedia-org-43 298 359 Pleiotrophin Pleiotrophin NNP en-wikipedia-org-43 298 360 Renalase Renalase NNP en-wikipedia-org-43 298 361 Thrombopoietin Thrombopoietin NNP en-wikipedia-org-43 298 362 ( ( -LRB- en-wikipedia-org-43 298 363 see see VB en-wikipedia-org-43 298 364 here here RB en-wikipedia-org-43 298 365 instead instead RB en-wikipedia-org-43 298 366 ) ) -RRB- en-wikipedia-org-43 298 367 Wnt wnt NN en-wikipedia-org-43 298 368 signaling signal VBG en-wikipedia-org-43 298 369 proteins protein VBZ en-wikipedia-org-43 298 370 Additional additional JJ en-wikipedia-org-43 298 371 growth growth NN en-wikipedia-org-43 298 372 factor factor NN en-wikipedia-org-43 298 373 receptor receptor NN en-wikipedia-org-43 298 374 modulators modulator NNS en-wikipedia-org-43 298 375 : : : en-wikipedia-org-43 298 376 Cerebrolysin Cerebrolysin NNP en-wikipedia-org-43 298 377 ( ( -LRB- en-wikipedia-org-43 298 378 neurotrophin neurotrophin JJ en-wikipedia-org-43 298 379 mixture mixture NN en-wikipedia-org-43 298 380 ) ) -RRB- en-wikipedia-org-43 298 381 See see VB en-wikipedia-org-43 298 382 also also RB en-wikipedia-org-43 298 383 Receptor Receptor NNP en-wikipedia-org-43 298 384 / / SYM en-wikipedia-org-43 298 385 signaling signal VBG en-wikipedia-org-43 298 386 modulators modulator NNS en-wikipedia-org-43 298 387 Signaling signal VBG en-wikipedia-org-43 298 388 peptide peptide NN en-wikipedia-org-43 298 389 / / SYM en-wikipedia-org-43 298 390 protein protein NN en-wikipedia-org-43 298 391 receptor receptor NN en-wikipedia-org-43 298 392 modulators modulator NNS en-wikipedia-org-43 298 393 Cytokine cytokine JJ en-wikipedia-org-43 298 394 receptor receptor NN en-wikipedia-org-43 298 395 modulators modulator NNS en-wikipedia-org-43 298 396 This this DT en-wikipedia-org-43 298 397 article article NN en-wikipedia-org-43 298 398 incorporates incorporate VBZ en-wikipedia-org-43 298 399 text text NN en-wikipedia-org-43 298 400 from from IN en-wikipedia-org-43 298 401 the the DT en-wikipedia-org-43 298 402 public public JJ en-wikipedia-org-43 298 403 domain domain NN en-wikipedia-org-43 298 404 Pfam Pfam NNP en-wikipedia-org-43 298 405 and and CC en-wikipedia-org-43 298 406 InterPro InterPro NNP en-wikipedia-org-43 298 407 : : : en-wikipedia-org-43 298 408 IPR002072 IPR002072 NNP en-wikipedia-org-43 298 409 Retrieved retrieve VBD en-wikipedia-org-43 298 410 from from IN en-wikipedia-org-43 298 411 " " `` en-wikipedia-org-43 298 412 https://en.wikipedia.org/w/index.php?title=Neurotrophin&oldid=993213849 https://en.wikipedia.org/w/index.php?title=neurotrophin&oldid=993213849 NN en-wikipedia-org-43 298 413 " " '' en-wikipedia-org-43 298 414 Categories category NNS en-wikipedia-org-43 298 415 : : : en-wikipedia-org-43 298 416 Neurochemistry Neurochemistry NNP en-wikipedia-org-43 298 417 Neurotrophic Neurotrophic NNP en-wikipedia-org-43 298 418 factors factor NNS en-wikipedia-org-43 298 419 Programmed program VBD en-wikipedia-org-43 298 420 cell cell NN en-wikipedia-org-43 298 421 death death NN en-wikipedia-org-43 298 422 Single single JJ en-wikipedia-org-43 298 423 - - HYPH en-wikipedia-org-43 298 424 pass pass NN en-wikipedia-org-43 298 425 transmembrane transmembrane NN en-wikipedia-org-43 298 426 proteins protein NNS en-wikipedia-org-43 298 427 Navigation Navigation NNP en-wikipedia-org-43 298 428 menu menu NN en-wikipedia-org-43 298 429 Personal personal JJ en-wikipedia-org-43 298 430 tools tool NNS en-wikipedia-org-43 298 431 Not not RB en-wikipedia-org-43 298 432 logged log VBN en-wikipedia-org-43 298 433 in in IN en-wikipedia-org-43 298 434 Talk Talk NNP en-wikipedia-org-43 298 435 Contributions Contributions NNP en-wikipedia-org-43 298 436 Create Create NNP en-wikipedia-org-43 298 437 account account NN en-wikipedia-org-43 298 438 Log Log NNP en-wikipedia-org-43 298 439 in in IN en-wikipedia-org-43 298 440 Namespaces Namespaces NNP en-wikipedia-org-43 298 441 Article Article NNP en-wikipedia-org-43 298 442 Talk talk NN en-wikipedia-org-43 298 443 Variants variant VBZ en-wikipedia-org-43 298 444 Views view NNS en-wikipedia-org-43 298 445 Read read VBP en-wikipedia-org-43 298 446 Edit edit NN en-wikipedia-org-43 298 447 View View NNP en-wikipedia-org-43 298 448 history history NN en-wikipedia-org-43 298 449 More More JJR en-wikipedia-org-43 298 450 Search Search NNP en-wikipedia-org-43 298 451 Navigation Navigation NNP en-wikipedia-org-43 298 452 Main Main NNP en-wikipedia-org-43 298 453 page page NN en-wikipedia-org-43 298 454 Contents content VBZ en-wikipedia-org-43 298 455 Current current JJ en-wikipedia-org-43 298 456 events event NNS en-wikipedia-org-43 298 457 Random random JJ en-wikipedia-org-43 298 458 article article NN en-wikipedia-org-43 298 459 About about IN en-wikipedia-org-43 298 460 Wikipedia Wikipedia NNP en-wikipedia-org-43 298 461 Contact Contact NNP en-wikipedia-org-43 298 462 us -PRON- PRP en-wikipedia-org-43 298 463 Donate Donate NNP en-wikipedia-org-43 298 464 Contribute contribute NN en-wikipedia-org-43 298 465 Help help NN en-wikipedia-org-43 298 466 Learn learn VB en-wikipedia-org-43 298 467 to to TO en-wikipedia-org-43 298 468 edit edit VB en-wikipedia-org-43 298 469 Community community NN en-wikipedia-org-43 298 470 portal portal JJ en-wikipedia-org-43 298 471 Recent recent JJ en-wikipedia-org-43 298 472 changes change NNS en-wikipedia-org-43 298 473 Upload upload JJ en-wikipedia-org-43 298 474 file file NN en-wikipedia-org-43 298 475 Tools tool NNS en-wikipedia-org-43 298 476 What what WP en-wikipedia-org-43 298 477 links link NNS en-wikipedia-org-43 298 478 here here RB en-wikipedia-org-43 298 479 Related relate VBN en-wikipedia-org-43 298 480 changes change VBZ en-wikipedia-org-43 298 481 Upload upload JJ en-wikipedia-org-43 298 482 file file VBP en-wikipedia-org-43 298 483 Special special JJ en-wikipedia-org-43 298 484 pages page NNS en-wikipedia-org-43 298 485 Permanent permanent JJ en-wikipedia-org-43 298 486 link link NN en-wikipedia-org-43 298 487 Page Page NNP en-wikipedia-org-43 298 488 information information NN en-wikipedia-org-43 298 489 Cite cite VB en-wikipedia-org-43 298 490 this this DT en-wikipedia-org-43 298 491 page page NN en-wikipedia-org-43 298 492 Wikidata wikidata NN en-wikipedia-org-43 298 493 item item NN en-wikipedia-org-43 298 494 Print print NN en-wikipedia-org-43 298 495 / / SYM en-wikipedia-org-43 298 496 export export NN en-wikipedia-org-43 298 497 Download Download NNP en-wikipedia-org-43 298 498 as as IN en-wikipedia-org-43 298 499 PDF PDF NNP en-wikipedia-org-43 298 500 Printable Printable NNP en-wikipedia-org-43 298 501 version version NN en-wikipedia-org-43 298 502 In in IN en-wikipedia-org-43 298 503 other other JJ en-wikipedia-org-43 298 504 projects project NNS en-wikipedia-org-43 298 505 Wikimedia Wikimedia NNP en-wikipedia-org-43 298 506 Commons Commons NNPS en-wikipedia-org-43 298 507 Languages Languages NNPS en-wikipedia-org-43 298 508 العربية العربية NN en-wikipedia-org-43 298 509 Deutsch Deutsch NNP en-wikipedia-org-43 298 510 Eesti Eesti NNP en-wikipedia-org-43 298 511 Español Español NNP en-wikipedia-org-43 298 512 فارسی فارسی JJ en-wikipedia-org-43 298 513 Français Français NNP en-wikipedia-org-43 298 514 Galego Galego NNP en-wikipedia-org-43 298 515 Bahasa Bahasa NNP en-wikipedia-org-43 298 516 Indonesia Indonesia NNP en-wikipedia-org-43 298 517 Italiano Italiano NNP en-wikipedia-org-43 298 518 Nederlands Nederlands NNP en-wikipedia-org-43 298 519 日本語 日本語 VBZ en-wikipedia-org-43 298 520 Português Português NNP en-wikipedia-org-43 298 521 Русский Русский NNP en-wikipedia-org-43 298 522 中文 中文 NNP en-wikipedia-org-43 298 523 Edit Edit NNP en-wikipedia-org-43 298 524 links link NNS en-wikipedia-org-43 298 525 This this DT en-wikipedia-org-43 298 526 page page NN en-wikipedia-org-43 298 527 was be VBD en-wikipedia-org-43 298 528 last last RB en-wikipedia-org-43 298 529 edited edit VBN en-wikipedia-org-43 298 530 on on IN en-wikipedia-org-43 298 531 9 9 CD en-wikipedia-org-43 298 532 December December NNP en-wikipedia-org-43 298 533 2020 2020 CD en-wikipedia-org-43 298 534 , , , en-wikipedia-org-43 298 535 at at IN en-wikipedia-org-43 298 536 11:39 11:39 CD en-wikipedia-org-43 298 537   _SP en-wikipedia-org-43 298 538 ( ( -LRB- en-wikipedia-org-43 298 539 UTC UTC NNP en-wikipedia-org-43 298 540 ) ) -RRB- en-wikipedia-org-43 298 541 . . . en-wikipedia-org-43 299 1 Text text NN en-wikipedia-org-43 299 2 is be VBZ en-wikipedia-org-43 299 3 available available JJ en-wikipedia-org-43 299 4 under under IN en-wikipedia-org-43 299 5 the the DT en-wikipedia-org-43 299 6 Creative Creative NNP en-wikipedia-org-43 299 7 Commons Commons NNP en-wikipedia-org-43 299 8 Attribution Attribution NNP en-wikipedia-org-43 299 9 - - HYPH en-wikipedia-org-43 299 10 ShareAlike ShareAlike NNP en-wikipedia-org-43 299 11 License License NNP en-wikipedia-org-43 299 12 ; ; , en-wikipedia-org-43 299 13 additional additional JJ en-wikipedia-org-43 299 14 terms term NNS en-wikipedia-org-43 299 15 may may MD en-wikipedia-org-43 299 16 apply apply VB en-wikipedia-org-43 299 17 . . . en-wikipedia-org-43 300 1 By by IN en-wikipedia-org-43 300 2 using use VBG en-wikipedia-org-43 300 3 this this DT en-wikipedia-org-43 300 4 site site NN en-wikipedia-org-43 300 5 , , , en-wikipedia-org-43 300 6 you -PRON- PRP en-wikipedia-org-43 300 7 agree agree VBP en-wikipedia-org-43 300 8 to to IN en-wikipedia-org-43 300 9 the the DT en-wikipedia-org-43 300 10 Terms term NNS en-wikipedia-org-43 300 11 of of IN en-wikipedia-org-43 300 12 Use Use NNP en-wikipedia-org-43 300 13 and and CC en-wikipedia-org-43 300 14 Privacy Privacy NNP en-wikipedia-org-43 300 15 Policy Policy NNP en-wikipedia-org-43 300 16 . . . en-wikipedia-org-43 301 1 Wikipedia Wikipedia NNP en-wikipedia-org-43 301 2 ® ® NNPS en-wikipedia-org-43 301 3 is be VBZ en-wikipedia-org-43 301 4 a a DT en-wikipedia-org-43 301 5 registered registered JJ en-wikipedia-org-43 301 6 trademark trademark NN en-wikipedia-org-43 301 7 of of IN en-wikipedia-org-43 301 8 the the DT en-wikipedia-org-43 301 9 Wikimedia Wikimedia NNP en-wikipedia-org-43 301 10 Foundation Foundation NNP en-wikipedia-org-43 301 11 , , , en-wikipedia-org-43 301 12 Inc. Inc. NNP en-wikipedia-org-43 301 13 , , , en-wikipedia-org-43 301 14 a a DT en-wikipedia-org-43 301 15 non non JJ en-wikipedia-org-43 301 16 - - JJ en-wikipedia-org-43 301 17 profit profit JJ en-wikipedia-org-43 301 18 organization organization NN en-wikipedia-org-43 301 19 . . . en-wikipedia-org-43 302 1 Privacy privacy NN en-wikipedia-org-43 302 2 policy policy NN en-wikipedia-org-43 302 3 About about IN en-wikipedia-org-43 302 4 Wikipedia Wikipedia NNP en-wikipedia-org-43 302 5 Disclaimers Disclaimers NNPS en-wikipedia-org-43 302 6 Contact Contact NNP en-wikipedia-org-43 302 7 Wikipedia Wikipedia NNP en-wikipedia-org-43 302 8 Mobile Mobile NNP en-wikipedia-org-43 302 9 view view NN en-wikipedia-org-43 302 10 Developers Developers NNP en-wikipedia-org-43 302 11 Statistics Statistics NNP en-wikipedia-org-43 302 12 Cookie Cookie NNP en-wikipedia-org-43 302 13 statement statement NN