id author title date pages extension mime words sentences flesch summary cache txt en-wikipedia-org-1179 Broken heart - Wikipedia .html text/html 3251 436 64 The neurological process involved in the perception of heartache is not known, but is thought to involve the anterior cingulate cortex of the brain, which during stress may overstimulate the vagus nerve causing pain, nausea or muscle tightness in the chest.[6] Research by Naomi Eisenberger and Matthew Lieberman of the University of California from 2008 showed that rejection is associated with activation of the dorsal anterior cingulate cortex and right-ventral pre-frontal cortex, areas established as being involved in processing of pain, including empathizing with pain experienced by others.[6] The same researchers mention effect of social stressors on the heart, and personality on perception of pain.[7] In severe cases, the depression of a broken heart can create a sustained type of stress that constitutes an emotional trauma which can be severe enough to leave an emotional imprint on individuals' psychobiological functioning, affecting future choices and responses to rejection, loss, or disconnection.[22] A contributing factor to the trauma-producing event is that 'being left' can trigger primal separation fear – the fear of being left with no one to take care of one's vital needs. ./cache/en-wikipedia-org-1179.html ./txt/en-wikipedia-org-1179.txt