id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280957-cdd6ngf1	Narkpuk, Jaraspim	The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin	2018-10-02		.txt	text/plain	6435	307	54	An MDCK-based cell line expressing human BST-2 was generated to study human-derived A/Puerto Rico/8/36 (H1N1; PR8) as well as two low pathogenic avian influenza viruses (subtypes H4N6 and H6N1). While this result reflects the ability of influenza A viruses in general to mediate host shut-off (Rivas et al., 2016) , it also suggests a difference in mRNA down-regulation that may be associated with decreased levels of BST-2. We report here that, contrary to our initial hypothesis that low pathogenic avian influenza viruses incapable of transmission to human hosts would be strongly restricted by human BST-2, H4N6 and H6N1 viruses grew to robust titers in MDCK cells constitutively expressing BST-2 and appeared completely resistant to its antiviral activity. We identified the PA segment as a species-specific determinant of sensitivity to BST-2, with those of low pathogenic avian influenza viruses exhibiting the ability to down-regulate human BST-2 in both transfection and infection contexts.	./cache/cord-280957-cdd6ngf1.txt	./txt/cord-280957-cdd6ngf1.txt