id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303884-ogu3f3o5	Abdelnabi, Rana	Antiviral Strategies Against Chikungunya Virus	2015-12-28		.txt	text/plain	4050	220	43	Antiviral agents targeting the entry of enveloped viruses are of major interest since they inhibit an early step in the viral life cycle which minimizes the cell damage caused by intracellular viral replication. Small interfering RNA (siRNA) sequences targeting CHIKV nsP3 and E1 genes were reported to signifi cantly reduce CHIKV titers at 24 h post-infection in transfected Vero cells [ 14 ] . In a highthroughput screening for CHIKV nsP2 inhibitors that target the nsP2-mediated transcriptional shut off, a natural compound derivative (ID1452-2) was shown to partially block the nsP2 activity resulting in inhibition of CHIKV replication in cell culture [ 29 ] . When designing/developing antivirals against the Chikungunya virus it may be important to develop classes of compounds that have pan-alphavirus activity and that could thus also be used for the treatment of alphaviruses other than CHIKV. Inhibition of Chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression	./cache/cord-303884-ogu3f3o5.txt	./txt/cord-303884-ogu3f3o5.txt