id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298503-l60cdllh	Saraste, J.	Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus	2015-08-20		.txt	text/plain	9539	451	48	Newly synthesized proteins and lipids leave the endoplasmic reticulum (ER) at specialized transitional regions called ER exit sites (ERES) (Jamieson and Palade, 1967; Sesso et al., 1994; Bannykh et al., 1996; Hammond and Glick, 2000; Tang et al., 2005) and enter the intermediate compartment (IC) that has been shown to operate as an obligatory a post-ER sorting station in the early biosynthetic-secretory trafficking of mammalian cells. Electron microscopic (EM) studies using a temperature-sensitive mutant of Semliki Forest virus (SFV ts-1) to synchronize the transport of viral membrane glycoproteins from ER to the plasma membrane (PM) showed that when the cells are shifted from 39 1C to 15 1C the proteins exit the ER, but accumulate in vacuoles/saccules (up to 0.5 mm in diameter), tubules, and vesicles in the cis-Golgi region and more peripheral locations (Saraste and Kuismanen, 1984) . ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells	./cache/cord-298503-l60cdllh.txt	./txt/cord-298503-l60cdllh.txt