id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297325-fbilhauu	Savarin, Carine	Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery	2015-11-11		.txt	text/plain	7581	404	48	Nevertheless, despite sustained demyelination and CNS inflammation, the SR T cell response declined during viral persistence, suggesting that chronic JHMV infection establishes an environment which supports ongoing clinical improvement and regulates autoimmune responses. This is supported by activation of JHMV-specific T cells within the CLN [34] and detection of myelin antigens in MS patients and rodents with experimental autoimmune encephalomyelitis (EAE) [35] [36] [37] , as well as following demyelination induced by oligodendrocyte death [38] . To determine whether CNSinfiltrating myeloid cells, comprising macrophages and dendritic cells, and/or microglia are capable of processing and presenting self-Ag within the CNS following infection, both potential APC populations were purified based on differential CD45 expression [44, 45] at distinct times p.i. and tested for the ability to support SR T cell activation in the absence of exogenously added Ag. Infiltrating myeloid cells at day 7 p.i.	./cache/cord-297325-fbilhauu.txt	./txt/cord-297325-fbilhauu.txt