id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296326-8oes5g6k	Botta, Giorgia	Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses	2015-09-01		.txt	text/plain	4102	246	53	30 Here we report the use of MWCNT/Tyr for the improved synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols, and their antiviral activity against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), Coxsackie virus type B3 (Cox B3), Adenovirus type 2 and type 5, and Cytomegalovirus (CMV). The activity of native Tyr (81.2 U/mg) was determined by the dopachrome assay following the oxidation of L-tyrosine at 475 nm (the enzyme unit is defined as the increase in absorbance of 10 À3 unit/min at 25°C in 0.1 M phosphate buffer, pH 7.0). In particular, compound 3b was added at different times on VERO cells infected with 0.1 MOI of HSV-1, to determine the inhibition of the virus yield during specific periods in the virus life-cycle.	./cache/cord-296326-8oes5g6k.txt	./txt/cord-296326-8oes5g6k.txt