id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273136-hrgtaunt	Rabelo, Luiza A.	Animal Models with a Genetic Alteration of the ACE2/Ang-(1-7)/Mas Axis	2015-04-24		.txt	text/plain	3893	238	44	The aim of this chapter is to describe the animal models generated by transgenic technology for the functional analysis of the protective axis of the renin–angiotensin system, consisting of angiotensin-converting enzyme 2 (ACE2), angiotensin (Ang)-(1-7), and Mas. Transgenic overexpression of the components of this axis in general led to an ameliorated cardiac and vascular damage in disease states and to an improved metabolic profile. 1, 2 The aim of this chapter is to describe the animal models generated by transgenic technology for the functional analysis of the protective axis of the RAS, consisting of angiotensin-converting enzyme 2 (ACE2), Ang-(1-7), and Mas. In biomedical research, the use of rats and mice has become a major tool, considering the easiness of breeding, growth, and maintenance and the similarity with human organisms in most cardiovascular and metabolic systems. Our group and others have developed several transgenic and KO rat and mouse models with genetic deletion and/or overexpression of components of the ACE2/Ang-(1-7)/Mas axis.	./cache/cord-273136-hrgtaunt.txt	./txt/cord-273136-hrgtaunt.txt