id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006137-nrw6zztp	Egan, Timothy J	Drug-resistant Plasmodium falciparum: are recent advances a cause for optimism?	2015-07-30		.txt	text/plain	1629	78	49	It is now widely accepted that mutations in the gene encoding PfCRT, a digestive vacuole (DV) transporter located in the DV membrane is the primary factor in CQ resistance in Plasmodium falciparum, albeit that other proteins probably also contribute to the level of resistance [6] . In the last few months two studies have investigated the physiological role of PfCRT and mechanism of PfKelch13-based artemisinin resistance, respectively. In the case of CQ-sensitive PfCRT 3D7 , a wide range of naturally occurring cationic species, including among others amino acids, peptides derived from hemoglobin degradation and glutathione, exerted a cis-inhibition of TEA transport into the liposomes. The inactive analog, deoxyartemisinin caused no such effect so that PI3P formation occurred uninhibited and SS-EEA1-mCherry remained "The problem of artemisinin resistance represents a serious risk to the future success of the malaria control and elimination program." Artemisinin resistance in Plasmodium falciparum malaria A molecular marker of artemisinin-resistant Plasmodium falciparum malaria	./cache/cord-006137-nrw6zztp.txt	./txt/cord-006137-nrw6zztp.txt